26 juillet

Kidney Int Reports http://www.kireports.org/

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  Keep Calm and Dialyze On: Debunking the Myths of Peritoneal Dialysis Leaks - McGrath S, Jain AK Kidney Int Reports
  Two papers in this edition of KIR explore the feasibility of urgent-start PD, addressing clinicians' concerns about using PD catheters without an adequate 'break-in' or healing period. The fears of leaks, infections or poor clearance from low-volume urgent-start PD has led many clinicians to (…) (Kidney International Reports (2024))
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  Invisible Threat: How Air Pollution Fuels Primary Glomerular Disease - Arjunmohan Mohan, Srinivasan Beddhu Kidney Int Reports
  Environmental pollution has a significant impact on global disease burden, healthcare costs, and mortality. Air pollution, especially fine particulate matter (PM2.5), has been increasingly recognized as a significant environmental risk factor for various health conditions. The impact of PM2.5 on (…) (Kidney International Reports (2024))

24 juillet

Kidney Int Reports http://www.kireports.org/

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  Elevated ambient temperature associates with increased CVD-risk among hemodialysis patients - Yuzhi Xi, Zachary S. Wettstein, Abhijit V. Kshirsagar, Yang Liu, Danlu Zhang, Yun Hang, Ana G. Rappold Kidney Int Reports
  Ambient temperatures have increased due to climate change in many parts of the world. Due to loss of renal function which impacts regulation of thermoregulatory mechanisms the ability to adapt and resilient to changing conditionals is particularly concerning among individuals with kidney (…) (Kidney International Reports (2024))
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  Bringing a systems approach to living donor kidney transplantation - Anna Horton, Katya Loban, Peter Nugus, Marie-Chantal Fortin, Lakshman Gunaratnam, Greg Knoll, Istvan Mucsi, Prosanto Chaudhury, David Landsberg, Michel R. Pâquet, Marcelo Cantarovich, Shaifali Sandal Kidney Int Reports
  Living donor kidney transplantation (LDKT) is the best treatment option for patients with kidney failure. Efforts to increase LDKT have focused on micro-level interventions and the need for systems thinking has been highlighted. We aimed to identify and compare health system-level attributes and (…) (Kidney International Reports (2024))
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  Clinical Outcomes of a Novel Multidisciplinary Care Program in Advanced Kidney Disease (PEAK) - Daniil Shimonov, Sri Lekha Tummalapalli, Stephanie Donahue, Vidya Narayana, Sylvia Wu, Lisa S. Walters, Roberta Billman, Barbara Desiderio, Sandra Pressman, Oliver Fielding, Kariel Sweeney, Daniel Cukor, Daniel M. Levine, Thomas S. Parker, Vesh Srivatana, Jeffrey Silberzweig, Frank Liu, Andrew Bohmart Kidney Int Reports
  Multi-disciplinary care (MDC) for late-stage chronic kidney disease (CKD) has been associated with improved patient outcomes compared with traditional nephrology care, but the optimal MDC model is unknown. In 2015, we implemented a novel MDC model for patients with late-stage CKD informed by the (…) (Kidney International Reports (2024))
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  Randomized Trial of Nitrate-Replete Beetroot Juice on Blood Pressure in Hypertensive Adults with ADPKD - Priyanka S. Sagar, James Elhindi, Katrina Chau, David C. Harris, Vincent Lee, Kamal Sud, Nikki Wong, Gopala K. Rangan Kidney Int Reports
  Reduced circulating levels of nitric oxide metabolites are hypothesised, in part, to drive hypertension in autosomal dominant polycystic kidney disease (ADPKD).1 Beetroot juice (BRJ), a rich dietary source of nitrate, increases nitric oxide metabolites via the entero-salivary nitrate-nitrite-NO (…) (Kidney International Reports (2024))

22 juillet

Kidney Int Reports http://www.kireports.org/

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  Droxidopa for management of chronic hypotension in haemodialysis - Anuradha Jayanti, Mohamed Elewa Kidney Int Reports
  Chronic hypotension, defined as systolic blood pressure (SBP) < 100 mmHg in the interdialytic period, affects 5-10% of haemodialysis (HD) patients, and is more prevalent among patients on long-term HD 1. This complication causes significant symptom burden from orthostasis. Although its (…) (Kidney International Reports (2024))

20 juillet

Kidney Int Reports http://www.kireports.org/

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  Sporadic ADPKD-IFT140 Absence of Family History as an Indicator of Clinical Mildness - Manuel Anderegg, Jan Halbritter Kidney Int Reports
  Polycystic kidney disease (PKD) has become recognized as a genetically and clinically heterogeneous condition, with new disease genes being discovered upon atypical presentation. Atypical presentation contrasts with the classic clinical picture of autosomal dominant PKD (ADPKD), which is (…) (Kidney International Reports (2024))
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  Increased blood-brain barrier permeability and cognitive impairment in patients with end-stage kidney disease - Mickaël Bobot, Eric Guedj, Noémie Resseguier, Julien Faraut, Philippe Garrigue, Vincent Nail, Guillaume Hache, Sandra Gonzalez, Nathalie McKay, Romain Vial, Dammar Bouchouareb, Guillaume Lano, Noémie Jourde-Chiche, Ariane Duval-Sabatier, Fabrice Guilaume, Benjamin Guillet, Stéphane Burtey Kidney Int Reports
  Chronic kidney disease (CKD) is associated with an increased risk of cognitive impairment. This cognitive impairment is associated with an increased permeability of blood-brain barrier (BBB) in rodents with CKD, linked to activation of aryl hydrocarbon receptor (AhR) by indoxyl sulphate (IS). (…) (Kidney International Reports (2024))
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  N-acetylcysteine in kidney disease: molecular mechanisms, pharmacokinetics, and clinical effectiveness - Estefani Y. Hernández-Cruz, Omar E. Aparicio-Trejo, Fadi A. Hammami, Daniel Bar-Shalom, Martin Tepel, Jose Pedraza-Chaverri, Alexandra Scholze Kidney Int Reports
  N-acetylcysteine (NAC) has shown beneficial effects in both acute and chronic kidney disease in preclinical and clinical studies. Different dosage and administration forms of NAC have specific pharmacokinetic properties that determine the temporal pattern of plasma concentrations of NAC and its (…) (Kidney International Reports (2024))

17 juillet

Kidney Int Reports http://www.kireports.org/

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  Lower parathyroid hormone levels are associated with reduced fracture risk in Japanese hemodialysis patients - Hirotaka Komaba, Takahiro Imaizumi, Takayuki Hamano, Naohiko Fujii, Masanori Abe, Norio Hanafusa, Masafumi Fukagawa Kidney Int Reports
  Secondary hyperparathyroidism affects bone metabolism and may lead to bone fragility. However, there is conflicting evidence as to whether parathyroid hormone (PTH) levels are associated with fracture risk and whether the relationship is linear or U-shaped. (Kidney International Reports (2024))
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  Peak Tricuspid Regurgitation Jet Velocity and Kidney Outcomes in Patients With Heart Failure With Preserved Ejection Fraction - Tatsufumi Oka, Hocine Tighiouart, Wendy McCallum, Marcelle Tuttle, Jeffrey M. Testani, Mark J. Sarnak Kidney Int Reports
  Although venous congestion secondary to elevated pulmonary artery pressure (PAP) has been hypothesized to worsen kidney function, the association of peak tricuspid regurgitation jet velocity (pTRV), a surrogate of PAP, with kidney outcomes remains uncertain in heart failure with preserved (…) (Kidney International Reports (2024))
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  Losing much more than a transplant: a qualitative study of kidney transplant recipients’ experiences of graft failure - Anita Marie Slominska, Elizabeth Anne Kinsella, Saly El-Wazze, Kathleen Gaudio, M. Khaled Shamseddin, Ann Bugeja, Marie-Chantal Fortin, Mireille Farkouh, Amanda Vinson, Julie Ho, Shaifali Sandal Kidney Int Reports
  Kidney transplant recipients with graft failure are a growing cohort of patients who experience high morbidity and mortality. Limited evidence guides their care delivery and patient perspective to improve care processes is lacking. We conducted an in-depth exploration of how individuals (…) (Kidney International Reports (2024))

16 juillet

Kidney Int Reports http://www.kireports.org/

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  Importance of IFT140 in Patients with Polycystic Kidney Disease Without a Family History - Takuya Fujimaru, Takayasu Mori, Akinari Sekine, Motoko Chiga, Shintaro Mandai, Hiroaki Kikuchi, Yutaro Mori, Yu Hara, Tamami Fujiki, Fumiaki Ando, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Ryoichi Hanazawa, Akihiro Hirakawa, Toshio Mochizuki, Tatsuya Suwabe, Yoshifumi Ubara, Shinichi Uchida, Eisei Sohara Kidney Int Reports
  Recently, the monoallelic loss-of-function IFT140 variant was identified as a causative gene for autosomal dominant polycystic kidney disease (ADPKD). In patients with polycystic kidneys who have a positive family history, >90% have pathogenic variants in PKD1 or PKD2, whereas only 1% have (…) (Kidney International Reports (2024))
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  Pilot study of valganciclovir-induced leukopenia in kidney transplant recipients with NUDT15 genetic variation - Madan M. Bahadur, Nikhil Dhope, Rejitha R. Kaimal, Ashay Shingare Kidney Int Reports
  Nucleoside diphosphate–linked moiety X-type motif 15 (NUDT15) enzyme is a member of nudix hydrolase enzyme family and inactivates nucleoside triphosphates.S1–S3 NUDT15 poor metabolizer and intermediate metabolizer phenotypes are at increased risk of adverse drug reactions to medications (…) (Kidney International Reports (2024))
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  Anticoagulation for the prevention of thrombotic events in nephrotic syndrome - David Massicotte-Azarniouch, Daniel J. Crona, Priscilla Karnabi, Bhadran Bose, Patrick H. Nachman, Marc Carrier, Mark Canney, David W. Johnson, Taewoo Lee, Raja Ramachandran, Vivekanand Jha, Nigel S. Key, Vimal K. Derebail Kidney Int Reports
  Nephrotic syndrome (NS) predisposes to venous thromboembolic events (VTE) with membranous nephropathy (MN) carrying the highest risk.1 Clinicians caring for NS patients must balance benefits of anticoagulation against potential harms, primarily bleeding. Management of VTE risk is complicated by (…) (Kidney International Reports (2024))

13 juillet

Kidney Int Reports http://www.kireports.org/

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  Biomarkers of Kidney Disease Progression in ADPKD - Ahmad Ghanem, Abdul Hamid Borghol, Fadi George Munairdjy Debeh, Stefan Paul, Bassel AlKhatib, Peter C. Harris, Pranav S. Garimella, Christian Hanna, Timothy L. Kline, Neera K. Dahl, Fouad T. Chebib Kidney Int Reports
  Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic kidney disorder and the fourth leading cause of kidney failure (KF) in adults. Characterized by a reduction in glomerular filtration rate (GFR) and increased kidney size, ADPKD exhibits significant variability in (…) (Kidney International Reports (2024))

11 juillet

Kidney Int Reports http://www.kireports.org/

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  Gene Expression Sets and Renal Profiling from the Renal AL Amyloid Involvement and NEOD00 (RAIN) Trial - Cindy I. Varga, Felix Eichinger, Viji Nair, Abhijit S. Naik, Samih H. Nasr S, Agnes B. Fogo, Denis Toskic, Matthias Kretzler, Raymond L. Comenzo R Kidney Int Reports
  There is an unmet need to understand the mechanisms by which amyloid deposition drives alterations in the kidney. We leveraged renal biopsies from amyloid light-chain (AL) amyloidosis participants of the Renal AL Amyloid Involvement and NEOD00 (RAIN) trial (NCT03168906) to perform (…) (Kidney International Reports (2024))

10 juillet

Kidney Int Reports http://www.kireports.org/

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  Pericatheter Leak Associated With Earlier Peritoneal Dialysis Initiation Does Not Influence Long-Term Outcomes - George Tsihlis, Kieren Pirabhahar, Frederika Sciberras, MaryAnn Nicdao, Laraine Aw, Alvie Agoo, Vincent Lee, Jennifer Li, Lukas Kairaitis, Kamal Sud, Jan Swinnen, Katrina Chau Kidney Int Reports
  Internationally, peritoneal dialysis (PD) is increasingly being commenced within 2 weeks of catheter insertion. Studies are warranted to evaluate outcomes of this strategy. (Kidney International Reports (2024))

6 juillet

Kidney Int Reports http://www.kireports.org/

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  Avacopan in Anti-Neutrophil Cytoplasmic Autoantibodies–Associated Vasculitis in a Real-World Setting - Jonas Zimmermann, Janis Sonnemann, Wolfram J. Jabs, Ulf Schönermarck, Volker Vielhauer, Markus Bieringer, Udo Schneider, Ralph Kettritz, Adrian Schreiber Kidney Int Reports
  Anti-neutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) represents a group of systemic autoimmune small vessel vasculitis, leading to significant morbidity and mortality due to extensive organ damage (including kidney failure)1 and treatment toxicity to medications such as (…) (Kidney International Reports (2024))

5 juillet

Kidney Int Reports http://www.kireports.org/

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  Association of Childhood IgA Vasculitis With Allergic Rhinitis and Chronic Rhinosinusitis - Weilin Xiong, Qingjun Zhu, Xiaolei Hu, Yehong Yuan, Yongwang Zhao, Xiaoping Jing, Qingyin Guo Kidney Int Reports
  Immunoglobulin A vasculitis (IgAV) is related to chronic inflammation; however, little is known about the associations between IgAV and allergic rhinitis (AR) or chronic rhinosinusitis (CRS). We evaluated the relationships among IgAV, AR, and CRS in children. (Kidney International Reports (2024))
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  Kidney Biopsy Findings After Lung Transplantation - David de Saint Gilles, Marion Rabant, Aurélie Sannier, Charlotte Mussini, Alexandre Hertig, Antoine Roux, Alexandre Karras, Eric Daugas, Vincent Bunel, Jerome Le Pavec, Renaud Snanoudj Kidney Int Reports
  The early diagnosis of histological kidney damage after lung transplantation (LT) is of paramount importance given the negative prognostic implications of kidney disease. (Kidney International Reports (2024))
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  Exploring Novel Adverse Events of Nefecon - Jingyu Wang, Zhao Zhang, Xingzi Liu, Sufang Shi, Jicheng Lv, Yuemiao Zhang, Hong Zhang Kidney Int Reports
  Nefecon, the first innovative drug approved by both the US Food and Drug Administration (FDA) and European Medicines Agency for IgA nephropathy (IgAN), lacked comprehensive real-world assessments of its adverse events (AEs). (Kidney International Reports (2024))

4 juillet

Kidney Int Reports http://www.kireports.org/

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  Corrigendum to “WCN24-813 MANAGEMENT OF ACUTE FLUID OVERLOAD IN HEART FAILURE PATIENTS WITH CKD USING HOME DELIVERED SUBCUTANEOUS FUROSEMIDE” [Kidney International Reports Volume 9, Issue 4, Supplement, April 2024, Page S251-S252] - Rosa Montero, Ashwin Anenden, Jane Nokes, Vasa Gnanapragasam, Mahrukh Ali, Sabba Hussain, Isaac Chung, Matthew Sunter, Laura Bijman, Tristan Williams, Nicholas Annear, Irina Chis Ster, Lisa Anderson, Debasish Banerjee Kidney Int Reports
  The authors regret that the first author’s name, Ella Tumelty1, was missing from the published abstract. (Kidney International Reports (2024))

1er juillet

Kidney Int Reports http://www.kireports.org/

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  Time Required to Perform Point-of-Care Ultrasound in an Academic Nephrology Hospital Service - Gary Tan, Daniel W. Ross Kidney Int Reports
  Point-of-care ultrasound (POCUS) is a real-time exam performed and interpreted by a treating physician at the time of a clinical encounter to answer a focused clinical question. In nephrology, POCUS is most used to identify kidney pathology and assess volume status.1,2 A recent survey by the (…) (Kidney International Reports (2024))
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  Antinephrin-Associated Primary Focal Segmental Glomerulosclerosis Successfully Treated With Plasmapheresis - Iain Bressendorff, Karl Emil Nelveg-Kristensen, Maryam Ghasemi, Andrew J.B. Watts, Johanna Elversang, Keith H. Keller, Finn Cilius Nielsen, Wladimir Szpirt, Astrid Weins Kidney Int Reports
  Minimal change disease and primary focal segmental glomerulosclerosis (FSGS) have similar clinical manifestations, both presenting with rapid-onset nephrotic syndrome and often amendable to treatment with high-dose glucocorticoids. Recently, antinephrin antibodies (Ab) have been reported to be (…) (Kidney International Reports (2024))
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  WCN24-2341 DIALYSIS ADEQUACY: IMPACT OF KT/V INDEX ON QUALITY OF LIFE IN LONG-TERM HEMODIALYSIS FOR END-STAGE RENAL DISEASE PATIENT - Martin Svibelcemic, Natalia Boccia, Gonzalo Garcia, Liliana Nigro, Anabel Abib, Gustavo Laham Kidney Int Reports
  Patients with end-stage renal disease (ESRD) undergoing long-term hemodialysis often experience a significant burden of incapacitating symptoms. While there is clear evidence of the relationship between dialysis adequacy measured by Kt/V and important clinical outcomes such as morbidity and (…) (Kidney International Reports 9, 7 (2024))
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  WCN24-1263 SYMPTOM IMPROVEMENT ENABLED BY THERANOVA DIALYZER IN HEMODIALYSIS PATIENTS: A BEFORE AND AFTER STUDY - Freddy Ardila, Francisco Sebastian, Sylvia Quiñonez, Mauricio Sanabria, Jasmin Vesga, Andrea Aldana, Angela Rivera Kidney Int Reports
  Expanded hemodialysis (HDx), enabled by medium cut-off dialyzers, has been shown to increase the clearance of large middle molecules, compared to high flux hemodialysis (HF HD). Clearance of large middle molecular uremic toxins resulted in improved clinical outcomes. Patients and healthcare (…) (Kidney International Reports 9, 7 (2024))

28 juin

Kidney Int Reports http://www.kireports.org/

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  A Metabolomics Approach to Identify Metabolites Associated With Mortality in Patients Receiving Maintenance Hemodialysis - Solaf Al Awadhi, Leslie Myint, Eliseo Guallar, Clary B. Clish, Kendra E. Wulczyn, Sahir Kalim, Ravi Thadhani, Dorry L. Segev, Mara McAdams DeMarco, Sharon M. Moe, Ranjani N. Moorthi, Thomas H. Hostetter, Jonathan Himmelfarb, Timothy W. Meyer, Neil R. Powe, Marcello Tonelli, Eugene P. Rhee, Tariq Shafi Kidney Int Reports
  Uremic toxins contributing to increased risk of death remain largely unknown. We used untargeted metabolomics to identify plasma metabolites associated with mortality in patients receiving maintenance hemodialysis. (Kidney International Reports (2024))
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  Activating the Flozin Shield: Cardioprotective Effects of Sodium-Glucose Cotransporter-2 Inhibitors in Kidney Transplant Recipients With Diabetes Mellitus - Krishnam Raju Penmatsa, Thangamani Muthukumar Kidney Int Reports
  Diabetic kidney disease, an all-encompassing term that includes both micro and macrovascular complications, is the leading cause of end-stage kidney disease worldwide. Posttransplant diabetes mellitus, a common complication after solid organ transplantation, is associated with graft loss, (…) (Kidney International Reports (2024))
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  Validation of a Clinical Scale for Early Detection of Infections at the Exit Site of Central Venous Catheters for Hemodialysis - José Luis Cobo-Sánchez, Ian Blanco-Mavillard, Raquel Pelayo-Alonso, Noelia Mancebo-Salas, Ismael Fernández-Fernández, Irene Larrañeta-Inda, Ana Ulzurrun-García, Isidro Sánchez-Villar, Fernando González-García, Julia Hernando-García, M Jesús Rollán-de la Sota, Luís Miguel Vieira-Barbosa Lopes, M del Rosario Prieto-Rebollo, Carolina Sesmero-Ramos, Catalina Jaume-Riutort, Rafael Casas-Cuesta, Mateo Alcántara-Crespo, Joan Ernest de Pedro-Gómez Kidney Int Reports
  Exit-site infections (ESI) of central venous catheters for hemodialysis (CVC-HD) has been associated with early catheter removal and an increased risk of CVC-HD related bacteremia. No specific clinical scales to predict ESI have previously been validated. (Kidney International Reports (2024))

27 juin

Kidney Int Reports http://www.kireports.org/

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  Immunoadsorption and Plasma Exchange are Comparable in Anti-Neutrophil Cytoplasmic Antibodies or Anti-Glomerular Basement Membrane Removal Kinetics - Marion Sallee, Noémie Resseguier, Thomas Crepin, Daniel Bertin, Dominique Bertrand, Mickaël Bobot, Thierry Krummel, Nicolas Maillard, Julie Moussi-Frances, Marion Pelletier, Pascale Poullin, Cédric Rafat, Thomas Robert, Benjamin Terrier, Lionel Rostaing, Stanislas Faguer, Noémie Jourde-Chiche Kidney Int Reports
  Apheresis allows the fast removal of autoantibodies in anti-glomerular basement membrane (anti-GBM) disease, and in severe antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis. The CINEVAS study tested whether immunoadsorption (IA) allowed a faster removal of ANCA and/or anti-GBM (…) (Kidney International Reports (2024))
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  A Randomized Controlled Trial Comparing Automated Peritoneal Dialysis and Hemodialysis for Urgent-Start Dialysis in ESRD - Haijiao Jin, Wei Fang, Ling Wang, Xiujuan Zang, Yueyi Deng, Guoqing Wu, Ying Li, Xiaonong Chen, Niansong Wang, Gengru Jiang, Zhiyong Guo, Xiaoxia Wang, Yinghui Qi, Shifan Lv, Zhaohui Ni Kidney Int Reports
  Peritoneal dialysis (PD) shows promise for urgent-start dialysis in end-stage renal disease (ESRD), with automated PD (APD) having advantages. However, there is limited multicenter randomized controlled trial (RCT) evidence comparing APD with temporary hemodialysis (HD) for this indication in China. (Kidney International Reports (2024))
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  Design and Rationale of the Phase 2 Baricitinib Study in Apolipoprotein L1–Mediated Kidney Disease (JUSTICE) - Opeyemi A. Olabisi, Nadine J. Barrett, Anika Lucas, Maurice Smith, Kenisha Bethea, Karen Soldano, Stephanie Croall, Azita Sadeghpour, Hrishikesh Chakraborty, Myles Wolf Kidney Int Reports
  Individuals of recent West African ancestry develop focal segmental glomerulosclerosis (FSGS) and hypertension-attributed end-stage kidney disease (HTN-ESKD) at 4 times the rate of White Americans. Two protein-coding variants of the Apolipoprotein L1 (APOL1) gene, G1 and G2, explain 50% to 70% (…) (Kidney International Reports (2024))
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  Exploring Apixaban Pharmacokinetics, Pharmacodynamics, and Safety in Hemodiafiltration Patients - Aurema Otero, Elena Rosselló-Palmer, Sergi Codina, Nuria Lloberas, Yurema Martínez, Naiara Santos, Judith Peñafiel, Raúl Rigo-Bonnin, Anna Vidal, Joan Peris, Sebastià Videla, Miguel Hueso Kidney Int Reports
  Direct oral anticoagulants have replaced vitamin K antagonists in the general population with nonvalvular atrial fibrillation due to their predictable anticoagulation profile, similar efficacy, and superior safety. However, their benefits remain unclear in patients on dialysis because studies (…) (Kidney International Reports (2024))
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  Early Intervention, Big Savings: The Future of CKD Management in Thailand - Blake Angell, Vivekanand Jha Kidney Int Reports
  Chronic kidney disease (CKD) is largely preventable and treatable; however, its burden continues to grow, particularly in low- and middle-income nations.1 The global kidney health community has long advocated implementing CKD detection and treatment programs; however, robust health economic (…) (Kidney International Reports (2024))