19 March

Kidney Int Reports http://www.kireports.org/

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  National Trends in Complications of Vascular Access for Hemodialysis and Analysis of Racial Disparities among Patients with End-Stage Renal Disease in the Inpatient Setting - Waseem Wahood, Edwin Takahashi, Dheeraj Rajan, Sanjay Misra Kidney Int Reports
  To assess the trends in access-related complications, as well as the impact of race on these complications, among admitted end-stage kidney disease (ESKD) patients receiving hemodialysis. (Kidney International Reports (2023))

18 March

Kidney Int Reports http://www.kireports.org/

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  Association of the Kidney Failure Risk Equation with High Healthcare Costs - Nancy L. Reaven, Susan E. Funk, Vandana Mathur, Thomas W. Ferguson, Julie Lai, Navdeep Tangri Kidney Int Reports
  The Kidney Failure Risk Equations (KFRE) are accurate and validated to predict the risk of kidney failure in individuals with chronic kidney disease (CKD), but their potential to predict healthcare costs in the US healthcare system is unknown. We assessed the association of kidney failure risk (...) (Kidney International Reports (2023))
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  Safety and Diagnostic Yield of Protocolized Percutaneous Kidney Biopsies in Mechanically Ventilated Patients with Acute Kidney Injury - Christopher Estiverne, Gearoid M. McMahon, David B. Mount, Giada Bianchi, Carol Daddio Pierce, Hasna Hakim, Helmut G. Rennke, Peter G. Czarnecki Kidney Int Reports
  Research Letter: (Kidney International Reports (2023))

13 March

Kidney Int Reports http://www.kireports.org/

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  Corrigendum to “Detecting MUC1 Variants in Patients Clinicopathologically Diagnosed With Having Autosomal Dominant Tubulointerstitial Kidney Disease” Kidney Int Reports
  (Kidney International Reports (2023))
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  Direct Kidney Involvement by Tropheryma whipplei - Salvatore E Mignano, Gregory Kozeny, Bobbi S Pritt, Sanjeev Sethi Kidney Int Reports
  Whipple disease (WD) is a rare disease typically associated with malabsorption, caused by Tropheryma whipplei.1,S1 Though commonly regarded as a gastrointestinal pathogen, WD is actually a multisystemic infection with symptoms reported in the joints, heart, lungs, and central nervous (...) (Kidney International Reports (2023))

12 March

Kidney Int Reports http://www.kireports.org/

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  Renal Limited Biopsy Proven Thrombotic Microangiopathy in a Heart Transplant Recipient - Joyita Bharati, Syed Haider, Simon W Maybaum, Kenar D Jhaveri, Vanesa Bijol, Nupur N Uppal Kidney Int Reports
  Thrombotic microangiopathy (TMA) is known to occur in the setting of solid organ transplantation (1). TMA after heart transplant is rare and usually described as hemolytic uremic syndrome comprising of acute kidney injury (AKI) and microangiopathic hemolytic anemia (MAHA) (2-5). We report a (...) (Kidney International Reports (2023))

10 March

Kidney Int Reports http://www.kireports.org/

• 00:00
  Evidence for Kidney Volume as a Measure of ADPKD Severity “Marches On” in the OVERTURE Study - Matthew B. Lanktree Kidney Int Reports
  In this issue of Kidney International Reports, Perrone et al.1 present data in a global prospective observational cohort that height-adjusted total kidney volume (htTKV) is associated with worse kidney outcomes; lower estimated glomerular filtration rate; and for the first time, more (...) (Kidney International Reports (2023))
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  Half a Century of Graft Survival after Deceased-Donor Kidney Transplantation - Daan Kremer, Stephan J.L. Bakker, Stefan P. Berger Kidney Int Reports
  In 1954, Joseph Murray performed a kidney transplantation between monozygotic twins, which is regarded as the first long-term successful kidney transplantation worldwide (1). The organ survived for eight years. In 1962, the first successful deceased-donor kidney transplantation between (...) (Kidney International Reports (2023))

6 March

Kidney Int Reports http://www.kireports.org/

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  Quantitative BOLD MRI for Estimating Intra-renal Oxygen Availability Demonstrates Kidneys Are Hypoxemic in Human CKD - Pottumarthi V. Prasad, Lu-Ping Li, Bradley Hack, Nondas Leloudas, Stuart M. Sprague Kidney Int Reports
  Kidney Blood oxygenation level dependent (BOLD) MRI has shown great promise in evaluating relative oxygen availability. The method is quite efficacious in evaluating acute responses to physiological and pharmacological maneuvers. Although associations between its outcome parameter, R2* and (...) (Kidney International Reports (2023))
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  Binding Truths: Seronegative anti-GBM disease mediated by IgM anti-GBM antibodies - Marilina Antonelou, Harry Horsley, Lauren Heptinstall, Mark Harber, Alan D Salama Kidney Int Reports
  Anti- Glomerular Basement Membrane (GBM) disease presents with rapidly progressive glomerulonephritis and frequently with associated alveolar haemorrhage. It is typically characterised by diffuse crescentic glomerular inflammation and linear deposition of immunoglobulin along the glomerular (...) (Kidney International Reports (2023))

3 March

Kidney Int Reports http://www.kireports.org/

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  IgA Nephropathy Patient Baseline Characteristics in the Sparsentan PROTECT Study - Jonathan Barratt, Brad Rovin, Muh Geot Wong, Charles E. Alpers, Stewart Bieler, Ping He, Jula Inrig, Radko Komers, Hiddo JL. Heerspink, Alex Mercer, Irene L. Noronha, Jai Radhakrishnan, Michelle N. Rheault, William Rote, Howard Trachtman, Hernán Trimarchi, Vlado Perkovic, PROTECT investigators Kidney Int Reports
  Sparsentan is a novel single-molecule dual endothelin angiotensin receptor antagonist with hemodynamic and anti-inflammatory properties and is not an immunosuppressant. The ongoing phase 3 PROTECT trial examines sparsentan in adults with IgA nephropathy (...) (Kidney International Reports (2023))
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  DNAJB9-Positive Tubulointerstitial-Predominant Fibrillary Nephritis - Amelie Bourhis, Mariam Priya Alexander, Sibel Erdogan Damgard, Zurab Albekioni, Loren Paola Hernandez Herrera Kidney Int Reports
  Fibrillary glomerulonephritis (FGN) is a rare disease, found in 0.4% to 1.4% of kidney biopsies1,2 and first described in 1977. FGN is defined by deposition of randomly oriented, nonbranching straight fibrils that lack a hollow center with a diameter ranging from 10 to 25 nm. The recent (...) (Kidney International Reports (2023))

2 March

Kidney Int Reports http://www.kireports.org/

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  Improving Maternal Health Following Complicated Pregnancy and Glomerulonephritis - Anoushka Krishnan, Giorgina Barbara Piccoli Kidney Int Reports
  Chronic kidney disease (CKD) bears a risk of complications in pregnancy, and complicated pregnancies increase the probability of having an undiagnosed kidney disease or of developing it.1,2 The kidney plays a central role in these complications; even minor kidney damage is associated with an (...) (Kidney International Reports (2023))

1 March

Kidney Int Reports http://www.kireports.org/

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  WCN23-0289 HYPERKALEMIA MANAGEMENT AT EMERGENCY DEPARTMENT – A SINGLE CENTRE STUDY AT A TERTIARY TEACHING HOSPITAL - S.K. Lim, M.Y. Lo Kidney Int Reports
  Hyperkalemia is a medical emergency which can potentially be life-threatening due to cardiac arrythmia. It has been found to increase risk for cardiovascular events, hospitalizations, ICU admissions, short-term mortality and all-cause (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0248 UNMASKING HYPERCALCEMIA: A CASE REPORT - A. ESTEVES, C. Pardinhas, M. Reis, E. Ferreira, H. Pinto, L. Escada, L. Santos, R. Alves Kidney Int Reports
  Rhabdomyolysis is a clinical syndrome resulting from severe muscle damage, characterized by elevated creatine kinase and electrolyte abnormalities, that can lead to acute kidney injury (AKI) in 10–65% of cases. After an initial hypocalcemic AKI phase, serum calcium levels usually normalize. In (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0176 DOES REMOTE USE OF CISPLATIN CAUSES CHRONIC HYPOMAGNESEMIA? - R. ALMARSHOODI, E. khater, O. Ouda Kidney Int Reports
  Cisplatin is platinum based chemotherapeutic agent used in various types of malignancies. It is well known for its nephrotoxicity which manifests as acute kidney injury, tubular dysfunction, Fanconi syndrome and hypomagnesemia. Cisplatin induced hypomagnesemia can affect up to 90% of patients. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0394 DOUBLE GLOMERULOPATHY OF THIN BASEMENT MEMBRANE DISEASE AND IGA NEPHROPATHY PRESENTING WITH NEPHROTIC SYNDROME IN AN ADULT WOMAN - J.K. Polito, E. Polito Kidney Int Reports
  Both IgA nephropathy and thin basement membrane disease are prevalent primary glomerulonephritis worldwide that usually presents with hematuria, hypertension, and varying degrees of proteinuria.1 However, nephrotic syndrome as its presentation has not been well characterized to date, and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0378 STUDY OF CLINICAL OUTCOME AND FOLLOW-UP OF MALE LUPUS NEPHRITIS IN A TERTIARY CARE CENTER - A. RATHOON, V. Gurusamy, V. Ganesan, A. Srinivasan Kidney Int Reports
  Lupus nephritis (LN) is an immune complex glomerulonephritis, which is a very serious complication of systemic lupus erythematosus (SLE) as it can progress to end-stage kidney disease (ESKD). It's more common in a female with a female-to-male ratio of around 10:1. The renal involvement in male (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0368 BLEEDING COMPLICATIONS AFTER PERCUTANEOUS KIDNEY BIOPSY – NATIONWIDE EXPERIENCE FROM BRUNEI DARUSSALAM - C.Y. LIM, S.L. Khay Kidney Int Reports
  Bleeding is a major risk of kidney biopsy. Numerous risk factors for bleeding post-biopsy have been reported, but findings have been inconsistent. We aim to investigate the risk factors for post-biopsy bleeding events in Brunei (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0353 RENAL BIOPSY REGISTRY FROM A SINGLE CENTRE IN INDIA: 20 YEARS EXPERIENCE - C. VEERAMANENI, M. sahay, K. ismal Kidney Int Reports
  Renal biopsy has a cardinal role in the management of kidney diseases. Renal biopsy registries in various countries have provided important information about the demographics of patients and the spectrum of renal parenchymal diseases in their population. v In the absence of nation-wide renal (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0347 RITUXIMAB THERAPY FOR DOUBLE-POSITIVE ANTIBODIES (ANCA AND ANTI-GBM ANTIBODIES) ASSOCIATED WITH GLOMERULONEPHRITIS - K. CHIENWICHAI, A. Chang, N. Sunanthamethee Kidney Int Reports
  Double-positive for anti-neutrophil cytoplasm antibodies (ANCA) and anti-glomerular basement membrane (anti-GBM) antibodies associated with glomerulonephritis is a relatively rare condition. Because of its aggressive clinical course, an effective induction regimen for clinical remission is (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0338 THE IMPACT OF DOSING STRATEGY ON CLINICAL OUTCOME IN LOW-DOSE CYCLOPHOSPHAMIDE-TREATED PATIENTS WITH LUPUS NEPHRITIS - K. CHIENWICHAI, A. Chang, S. Sangaew, A. Choomnirat Kidney Int Reports
  Cyclophosphamide is the mainstay treatment for patients with lupus nephritis (LN). Cyclophosphamide may be prescribed in lower doses than the recommended regimen to avoid side effects. We investigated the impact of the dosing strategy on the treatment outcome of patients who were initially (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0334 VITAMIN D LEVEL IN SLE PATIENTS WITH OR WITHOUT RENAL INVOLVEMENT AND IT’S RELATIONSHIP WITH DISEASE ACTIVITY (SLEDAI SCORE) - F. NOBI, M. Debnath, S. Mahjabin, T.K. Biswas, I. Ashraf, S. Azad, M.Z. Ahmad, B. Mobashwera, M. Akhtar, R. Emon, M.N. Chowdhury, M.N. Islam, M.T. Miah Kidney Int Reports
  Systemic lupus erythematosus (SLE) is one of the most frequent autoimmune rheumatological diseases responsible for higher mortality and morbidity rate. Although the factors contributing towards the pathogenesis of SLE have not yet been completely elucidated, genetic influences, environmental, (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0320 DDAVP for bleeding prophylaxis in patients undergoing kidney biopsy procedures: A randomized controlled trial. - P. LAUNGCHUAYCHOK, S. Jaturapisanukul, T. Claimon, W. Pongsittisak, T. Ngamvichchukorn, S. Kurathong, T. Trakarnvanich, T. Teepprasan Kidney Int Reports
  Bleeding is a common complication in a kidney biopsy procedure. DDAVP is generally used in kidney biopsy for bleeding prevention, despite lacking evidence to confirm its efficacy. Only 1 RCT showed the utility of DDAVP for bleeding prevention in eGFR?60 ml/min/1.73m2, but the benefit of using (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0308 CLINICAL AND HISTOPATHOLOGICAL PATTERN OF KIDNEY DISEASES IN EGYPT: SINGLE CENTRE STUDY, UPDATE - H. ABO SHOUSHA, S. Zaghloul, W. Hemida, H. Foula Kidney Int Reports
  In the recent years, kidney diseases are attracting both national and global attention due to the rapid increase its incidence and the fact that it is largely preventable and treatable. Identification of variable pattern kidney diseases either glomerular or non-glomerular in a population-based (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0305 ANCA ASSOCIATED GLOMERULONEPHRITIS IN A TERTIARY CENTRE IN MALAYSIA: CLINICAL CHARACTERISTICS, TREATMENT AND OUTCOME - L. Yee Wan, A. Hing Wong, S.E. Lim, M.L. Ng, H.Y. Kim, K.P. Ng, C.M. Wong, W.A.H. Wan Md Adnan, M. Jalalonmuhali, C.C. Gan, S.F. Cheng, C.C. Chew, S.H. Ooi, S.K. Lim Kidney Int Reports
  Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are a group of disorders characterized by severe, systemic, small-vessel vasculitis. AAVs can be classify according to ANCA autoantibodies specifically myeloperoxidase (MPO) or proteinase 3 (PR3) positive as this is more (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0288 ROLE OF NEUTROPHIL LYMPHOCYTE RATIO(NLR) AND PLATELET LYMPHOCYTE RATIO(PLR ) AS MARKERS OF DISEASE ACTIVITY IN SLE PATIENTS WITH OR WITHOUT RENAL INVOLVEMENT - S.I. HOSSEN, M.K. Hasan, M.S. Islam, A.T. Anwar, M.N. Islam Kidney Int Reports
  Different white blood cells show some changes in systemic inflammation such as neutrophilia and lymphopenia. Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) have recently been investigated as two new inflammatory markers in the assessment of systemic inflammation in many (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0266 RETROPSECTIVE ANALYSIS OF EPIDEMIOLOGY AND CLINICOPATHOLOGIC CORRELATIONS OF RENAL BIOPSY FINDINGS FROM COSTAL SOUTH INDIA OVER TEN YEARS - P. NAMBOODIRI, J. Dsilva, J. Anto Kidney Int Reports
  Percutaneous Renal Biopsy(PRB) , a cornerstone for diagnosis of different renal pathologies and to know prognosis of several primary and secondary kidney diseases(1)The indications for a PRB are represented by nephritic,nephrotic syndrome and rapidly progressive acute renal failure of unknown (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0227 C4d STAINING IN RENAL HISTOPATHOLOGY AS A PREDICTOR OF CLINICAL PRESENTATION AND SHORT-TERM OUTCOME IN LUPUS NEPHRITIS - N. AMIN, A. ALIMUL BARI, M.N. Islam, M.R. Alam, S.J. Islam, M.R. Rahman, S. Amin, F. Jahan Kidney Int Reports
  Systemic lupus erythematosus (SLE) is a multisystem disorder that commonly affects the kidney, when it is known as lupus nephritis (LN). Despite treatment, about 30% of LN patients progress to end stage kidney disease (ESKD) within 10 years of onset. Renal histopathology is the best way to (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0223 CLINICAL AND PATHOLOGICAL CHANGES IN PATIENTS WITH IgA NEPHROPATHY-A PROSPECTIVE COHORT STUDY FROM INDIA - U. Anandh, S. Hurmath, N.S. Vennavalli, S. Babu Kidney Int Reports
  IgA nephropathy is the most common glomerular disease in all parts of the world where kidney biopsies are done regularly. In India, there is data to suggest that IgA nephropathy is a progressive disease and most patients reach end-stage kidney disease at a faster rate than expected compared to (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0220 COMPARATIVE STUDY BETWEEN SINGLE DOSE RITUXIMAB THERAPY VERSUS MULTIPLE DOSE REGIMEN IN IDIOPATHIC MEMBRANOUS NEPHROPATHY AND ITS CORRELATION WITH PERIPHERAL BLOOD CD19 COUNT - A. KARGUPTA, P. Mukhopadhyay, M. Kataruka, S. Dasgupta, A. Rudra, A. Mukherji, A.K. Biswas, M.I. Khan Kidney Int Reports
  Idiopathic membranous nephropathy (IMN) is a very common cause of nephrotic syndrome in adult population & can lead to CKD unless treated. Cyclophosphamide based therapy or CNI are associated with significant toxicity & high relapse rate on discontinuation. Rituximab is a safer option, (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0198 METRONIDAZOLE INDUCED LUPUS ERYTHEMATOSUS: A RARE CASE WITH NOVEL CLINICAL PRESENTATION - M. CHHAKCHHUAK, L. Khiangte, L. Renthlei Kidney Int Reports
  Drug-induced lupus (DIL) is an autoimmune condition where a drug exposure leads to the development of idiopathic systemic lupus erythematosus (SLE) like clinical features in a genetically susceptible individual, but typically without the major organ-threatening complications. The mechanism of (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0177 ACUTE KIDNEY INJURY IN SCLERODERMA - IT'S NOT ALWAYS RENAL CRISIS - A. BROWN, A. Singh, P. Moodley, T. Cornish Kidney Int Reports
  We present an interesting case of ANCA positive vasculitis in the context of systemic sclerosis (SS). This case is notable, as ANCA positive vasculitis and scleroderma renal crisis (SRC) are serious complications of SS. They can present similarly but are managed differently. We highlight the (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0172 CRANIAL VERSUS CAUDAL DIRECTION TECHNIQUE OF NATIVE PERCUTANEOUS KIDNEY BIOPSY: A RANDOMIZED CONTROLLED TRIAL - S. JATURAPISANUKUL, C. Chavanisakun, N. Benjakul, T. Ngamvichchukorn, P. Laungchuaychok, S. Kurathong, W. Phongsitthisak Kidney Int Reports
  Percutaneous kidney biopsy (PKB) is the gold standard for diagnosing various kidney diseases but can result in potential complications. Our study aims to compare the adequacy of kidney tissue and safety between the two directions of biopsy techniques: cranial direction and the caudal direction (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0169 MULTIPLE FACETS OF KIDNEY BIOPSY IN MULTIPLE MYELOMA : A RETROSPECTIVE OBSERVATIONAL STUDY - M. Shankar, U. Anandh, S. Guditi Kidney Int Reports
  Multiple myeloma is a type of plasma cell dyscrasia, causing clonal proliferation of plasma cells and deposition in various organ systems. At presentation, 50% of patients with multiple myeloma have kidney dysfunction, which is considered a poor prognostic indicator. With the advent of newer (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0150 ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE WITH COEXISTING IgA NEPHROPATHY AND ULCERATIVE COLITIS: A CASE REPORT - M. CHENG, C. Ong Kidney Int Reports
  Anti-glomerular basement membrane (GBM) disease is a rare, severe form of rapidly progressive glomerulonephritis characterised by circulating anti-GBM antibodies. Co-existence with myeloperoxidase-ANCA vasculitis is well-established, but not with IgA nephropathy although there have been rare (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0141 A PHASE 2 STUDY EVALUATING THE EFFICACY AND SAFETY OF ALXN2050, A COMPLEMENT FACTOR D INHIBITOR, IN IMMUNOGLOBULIN A NEPHROPATHY OR PROLIFERATIVE LUPUS NEPHRITIS (LN) - A. Bapat, K. Garlo, K. Rice, N. Najafian Kidney Int Reports
  IgA nephropathy and LN are glomerular diseases characterized by immune complex deposition, complement system activation and inflammation. Despite treatment, many patients with IgA nephropathy or LN progress to kidney failure. This global, multicenter, phase 2 study (NCT05097989) will evaluate (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0140 A PHASE 2 STUDY EVALUATING THE EFFICACY AND SAFETY OF RAVULIZUMAB IN PATIENTS WITH IMMUNOGLOBULIN A (IgA) NEPHROPATHY OR PROLIFERATIVE LUPUS NEPHRITIS (LN) - A. Kateifides, K. Garlo, K. Rice, N. Spoerri, N. Najafian Kidney Int Reports
  IgA nephropathy and LN are characterized by deposition of immune complexes, leading to activation of complement and inflammation. Despite treatment, many patients with IgA nephropathy or LN progress to kidney failure. This global, multicenter, phase 2 study (NCT04564339) will evaluate the (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0119 IMMUNOGLOBULIN A (IgA) NEPHROPATHY ASSOCIATED WITH ACUTE HEPATITIS E INFECTION (HEV) – FIRST CASE REPORT - S.S. Cheema, M.F. Cheema, S. Cheema Kidney Int Reports
  IgA Nephropathy (IgAN) is the most common lesion found to cause primary (idiopathic) glomerulonephritis throughout most resource-abundant countries of the world. There are case reports of IgAN associated with other conditions like HBV, HCV, HAV, HIV, celiac disease, alcoholic liver disease and (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0107 UNUSUAL CASE OF DUAL NEPHROPATHY: A CASE REPORT - P. Malavade, D. ranarajan, R. santanaraman Kidney Int Reports
  MYH9-related diseases ( myosin, heavy chain 9, non-muscle related diseases) are autosomal dominant disorders caused by mutations of the MYH9 gene. Gene is located on chromosome 22q and codes for NMMHC IIA (Kidney International Reports 8, 3 (2023))
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  WCN23-0095 ALPORT SYNDROME WITH A NOVEL DISEASE-CAUSING VARIANT MUTATION PREVIOUSLY MISDIAGNOSED WITH MESANGIAL PROLIFERATIVE GLOMERULONEPHRITIS - J.H. Jung MD, A. Seon-Ho Kidney Int Reports
  The kidney biopsy is an important method for an exact diagnosis in patients with glomerulonephritis (GN). However, as Alport syndrome is often mistaken for other GN such as mesangial proliferative glomerulonephritis (MesPGN) and focal and segmental glomerulosclerosis (FSGS), biopsy findings in (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0084 ANCA NEGATIVE PAUCI-IMMUNE CRESCENTIC GLOMERULONEPHRITIS ; A SINGLE CENTRE EXPERIENCE IN A TERTIARY CARE CENTRE IN EASTERN INDIA - S. SADHUKHAN, T. bhuniya, A. raychaudhury, A. pal, K. bhattacharjee, D. sen Kidney Int Reports
  Pauci-immune crescentic glomerulonephritis (CrGN) is the most common cause of rapidly progressive glomerulonephritis (RPGN) . Although majority of cases have the anti-neutrophil cytoplasmic antibodies (ANCAs) positivity, a subgroup of patients are ANCA negative. There are only few studies (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0069 EFFICACY AND SAFETY OF REDUCED-DOSE ORAL METHYLPREDNISOLONE IN IGA NEPHROPATHY: THE TESTING TRIAL - D. KIM, J. Lv, M. Hladunewich, V. Jha, L.S. Hooi, H. Monaghan, L. Billot, H. Zhang, V. Perkovic, M.G. Wong Kidney Int Reports
  The TESTING study recently reported that corticosteroids reduce the risk of major kidney events and kidney failure in individuals with IgA nephropathy (IgAN) at high risk of disease progression compared to supportive care alone, but that these benefits come with an increased risk of serious (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0042 OBSERVATIONAL STUDY COMPARING RITUXIMAB AND TACROLIMUS IN TREATMENT OF IDIOPATHIC MEMBRANOUS NEPHROPATHY - A. NANDA Kidney Int Reports
  Primary membranous nephropathy is one of the commonest causes of adult-onset nephrotic syndrome and also a common glomerular cause of End-Stage Renal Disease (ESRD). It is a B-cell mediated disease and rituximab, an anti CD20 monoclonal Ab has emerged as a promising treatment option. Current (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0033 PRESENTATION OF IDIOPATHIC MESANGIAL PROLIFERATIVE GLOMERULONEPHRITIS IN BANGLADESH- A SINGLE CENTRE STUDY AT TERTIARY CARE HOSPITAL Abstract paid for submission 2022-A-WCN23-0031(101403392091) - R. Das Gupta, S.M. Morshed, F. Ahmed, M.M. Hasan, G.F. Bhuiyan, M.N. Hasan, S.M. Shamsuzzaman, D.A. AL MAMUN Kidney Int Reports
  Global burden of glomerular disease is significant. Among 375 patients with glomerular disease, mesangial proliferative glomerulonephritis was found 111(29.6%) at a tertiary care hospital in Bangladesh. Their aetiology was not known. It is known that idiopathic mesangial proliferative (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1209 MORPHOLOGICAL PHENOTYPE ATLAS OF THE KIDNEY IN THE DEVELOPING C57BL/6 MICE - S. yang, X. bai, Z. yan, X. haosen, L. jinyi, L. peimin Kidney Int Reports
  C57BL/6 mice are commonly used murine models with the desired genetic background for modification in different research settings. Though these mice breed well, have long life spans, and have a low susceptibility to tumors, they are relatively resistant to the development of renal injury in (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0066 Identifying druggable pathways in IgA Nephropathy using spatial transcriptomics - H. SELVASKANDAN, I. Pawluczyk, J. Barratt Kidney Int Reports
  IgA nephropathy (IgAN) is the most commonly reported primary glomerular disease worldwide. It mainly affects young adults; about 30% develop kidney failure 10-20 years from diagnosis. Five histopathological kidney lesions independently predict a poor prognosis in IgAN (MEST-C score). Published (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-1146 NEW-ONSET HYPOKALEMIA IN A TRANSPLANT RECIPIENT- NOT THE USUAL SUSPECTS! - S. BATHINI Kidney Int Reports
  Kidney transplantation is the ideal form of renal replacement therapy. It encompasses a complex interplay of immunity and drugs and represents a transformational change in the adaptability of human tissues from two different bodies. Kidney transplant recipients have higher frequency of (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-1142 LYTES DON'T LIE: A CASE OF SEVERE METABOLIC ALKALOSIS IN A PATIENT WITH GASTRIC OUTLET OBSTRUCTION (GOO) - H. Abid, H. Alshamsi Kidney Int Reports
  History taking is a good tool to limit differential diagnosis and guide further investigations. Barriers to good history taking include patient related and clinicians related factors. Some of the patient’s related factors include language barrier, intoxication, disabilities, and aggression. Our (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-1123 THROUGH THE LOOKING GLASS: GITELMAN AND GORDON’S SYNDROMES - TWO CASE REPORTS - F. RODRIGUES, M. Dias, C. Cardoso, F. Teixeira e Costa, J. Silva Kidney Int Reports
  The thiazide-sensitive sodium-chloride cotransporter (NCC) enables their reabsorption throughout the distal convoluted tubule (DCT) and it’s central in potassium homeostasis. The transporter is coded by the SLS12A3 gene and its expression is controlled by the serine/threonine kinases, WNK1 and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1102 PSEUDOHYPONATREMIA: CLINICAL UTILITY OF ARTERIAL BLOOD GAS - C. Wannaphut, M.K.M. Siu, R. Salasnek, S. Lei, W. Pangkanon, N. Chaisrimaneepan, C. Lopimpisuth, P. Lalitnithi, C. Thimphitthaya, P. Wattanachayakul, P. Naunsilp, E. Tantisattamo Kidney Int Reports
  Hyponatremia is the most common electrolyte disturbance encountered in clinical practice. While the clinical manifestation of hyponatremia is non-specific and the underlying etiologies are broad, a systematic approach to hyponatremia can guide clinicians to pursue the diagnosis. We report a (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1063 RARE PRESENTATION OF PRIMARY SJOGREN’S SYNDROME-HYPOKALEMIC PARALYSIS-A CASE REPORT - N. ANJUM, Z. Nabi, H. ur Rehman Kidney Int Reports
  Sjogren's Syndrome is a multisystem autoimmune disorder characterized by chronic inflammation of exocrine glands, sicca syndrome. Among extra glandular manifestations renal involvement occurs as tubulointerstitial nephritis (TIN) and glomerular damage. Distal renal tubular acidosis (dRTA) is (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0863 INCORPORATION OF A TUBULAR DYSFUNCTION STAGING SYSTEM INTO THE DIAGNOSTIC CRITERIA OF ACUTE KIDNEY INJURY FOR ASSESSMENT OF ACUTE RENAL INSULT AMONG CRITICALLY ILL CHILDREN - W.F. HUI, W.L. Cheung, K.L. Hon, S.W. Ku Kidney Int Reports
  Electrolyte disturbances are commonly overlooked conditions among critically ill children. We evaluated the relationship between electrolyte disturbances and tubular dysfunction among critically ill children and determined the role of incorporating the severity of tubular dysfunction into the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0785 RISK OF HYPONATREMIA AFTER TRAMADOL/ACETAMINOPHEN SINGLE PILL COMBINATION MEDICATIONS: A REAL WORLD STUDY BASED ON THE OMOP-CDM DATABASE - K. Jinmi, L. Eu Jeong, H. RHEE Kidney Int Reports
  Tramadol/Acetaminophen fixed-dose combination oral pills are commonly used analgesics. Although it is known to be safer than non-steroidal anti-inflammatory drugs, several reports have signed a possible association between tramadol and hyponatremia. The objective of this study is to determine (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0681 Efficacy and safety of sucroferric oxyhydroxide vs sevelamer carbonate in Chinese dialysis patients with hyperphosphataemia - J. Liu, L. Zuo, S. Walpen, L. Bernard, M. Marty, M. Enoiu Kidney Int Reports
  Sucroferric oxyhydroxide (SFOH) is a non-calcium-based, oral iron-containing phosphate binder that has been demonstrated to be efficacious and generally well tolerated for the control of serum phosphorus (sP) in patients with chronic kidney disease undergoing dialysis. This study aimed to (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0656 WARBURG EFFECT IN A PATIENT WITH HIGH ANION GAP METABOLIC ACIDOSIS - J.D. DIAZ GARCIA, O.D.C. Díaz Avendaño, L. López González, M.E. Alamilla Sánchez, I.G. Ramírez Santana, E.F. Morales López, V. Yanez Salgado, J.C. Nieto Gutiérrez Kidney Int Reports
  Lactic acidosis results from the accumulation of lactate and protons in body fluids, it usually occurs when the production of lactate exceeds its consumption. It usually develops in the context of hypoxia, being called type A lactic acidosis; however, in a small percentage it is usually the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0638 RISK OF POSTOPERATIVE HYPERMAGNESEMIA IN CARDIOPULMONARY BYPASS ASSISTED OPEN-HEART SURGERIES AMONG PATIENTS WITH NORMAL AND LOW KIDNEY FUNCTION - M. GHADDAR, A. El-Kaakour, H. Tamim, M. Makki, T. El-Halabi, T. Hatab, K. Rifaii, P. Sfeir, M. Hoteit, S.H. Koubar Kidney Int Reports
  Magnesium containing solutions for cardioplegia are commonly used in open heart surgeries. However, data on their safety are scarce particularly in patients with chronic kidney disease (CKD) who are at higher risk of hypermagnesemia. In this study, we aimed to calculate the incidence of (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0434 THE FURTHER EVALUATION OF A PATIENT WITH ALLEGED PSYCHOGENIC POLYDIPSIA REVEALED A KINDRED WITH NEPHROGENIC DIABETES INSIPIDUS WITH A NOVEL MUTATION IN AVPR2 - C. Pleros, I. PETRAKIS, I. Stavrakaki, E. Drosataki, M. Mitrakos, K. Dermitzaki, N. Kroustalakis, A. Androvitsanea, D. Lygerou, M. Konidaki, N. Papadakis, A. Passam, I. Katsipi, I. Zaganas, K. Stylianou Kidney Int Reports
  Arginine Vasopressin receptor 2 (AVPR2) has seven transmembrane domains. It belongs to the G protein-coupled receptor (GPCR) superfamily. AVPR2 gene has a strong expression within the kidney tubule with a distant convoluted tubule (DCT) expression predominance. Upon its binding of AVP to AVPR2 (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1145 A COMPARATIVE LONG TERM OUTCOME STUDY OF DIFFUSE CRESCENTIC IMMUNOGLOBULIN A NEPHROPATHY AND ANCA ASSOCIATED PAUCIMMUNE CRESCENTIC GLOMERULONEPHRITIS - M. KHURANA, N. Prasad Kidney Int Reports
  Diffuse crescentic IgAN (CIgAN), usually defined as crescents in over 50% of the glomeruli and is an uncommon but aggressive phenotype of IgA Nephropathy. PCGN (Paucimmune Crescentic glomerulonephritis) is overall the most common cause of crescentic glomerulonephritis. CIgAN is treated (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1136 MONOCYTE-DERIVED CIRCULATING MICROPARTICLES AND SOLUBLE CD163 LEVELS IN IgAN - S. PRATAP SINGH, S. Kamthan, N. Prasad, V. Agarwal, V. Agrawal Kidney Int Reports
  Macrophages contribute to kidney injury by a variety of mechanisms. CD163, a M2-macrophage marker has been shown to be associated with glomerular inflammation and renal fibrosis. Microparticles (MPs) originate from cells on activation and injury and can act as non-invasive biomarkers. We (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1120 PREDICTION OF PATIENTS OUTCOME WITH IgA NEPHROPATHY UTILIZING OXFORD M.E.S.T-C SCORE - A.I. Akl, M.M. Fakeeh Kidney Int Reports
  The Oxford M.E.S.T-C score is a well-established histopathologic scoring system for IgA nephropathy patients (IgAN). To analyze clinical and histopathological patient data in order to predict the best course of treatment for a positive (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1119 Clinical Profile, Response and Outcome of Various Immunosuppressive Regimens Used For Treatment of Idiopathic Membranous Nephropathy –A Retrospective Cohort Study - L. S R, M. Saigal, S. Guditi, G. Taduri Kidney Int Reports
  Membranous nephropathy (MN) is a glomerular disease that can occur at all ages and is the most frequent cause of nephrotic syndrome. It is an autoimmune disease characterized by a thickening of the glomerular capillary walls due to immune complex deposition. Various modalities have been tried (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1097 Primary steroid resistant nephrotic syndrome as part of Schimke-immunoosseous dysplasia features in a girl: a case report - H.A. Puspitasari, C.N. Hafifah, E.L. Hidayati, D. Muktiarti, B. Alodia Kidney Int Reports
  Steroid-resistant nephrotic syndrome (SRNS) in children accounted for 10-15% of childhood idiopathic nephrotic syndrome cases. SRNS can be caused by immune system dysfunction or genetic abnormalities. Previously, histopathological features are the primary modalities for diagnostic and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1066 DETERMINATION OF NEUTROPHIL- LYMPHOCYTE AND PLATELET- LYMPHOCYTE RATIO AS A PREDICTORS OF LUPUS NEPHRITIS ACTIVITY - V. Rabrenovic, M. Petrovic, M. Rabrenovic, D. Pilcevic, N. Rancic, B. Vukomanovic Djurdjevic, M. Petrovic, N. Vavic Kidney Int Reports
  Neutrophil – lymphocyte ratio (NLR), and platelet- lymphocite ratio (PLR) as a marker of systemic inflammation is an important prognostic parameter of many diseases (malignant diseases, infections, septic conditions, cardiovascular diseases. The aim of this study was to investigate the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1050 THE EFFICACY OF 24-HOUR VERSUS 6-HOUR BED REST ON REDUCING POST-KIDNEY BIOPSY BLEEDING: A RANDOMIZED CONTROLLED TRIAL - G. KAFLEY, W. Pichitporn Kidney Int Reports
  Percutaneous kidney biopsy is an important procedure for the diagnosis of glomerular diseases, but post kidney biopsy bleeding is a serious and life-threatening complication. Post kidney biopsy bleeding may be reduced by longer absolute bed rest post-procedure. Whether the optimal duration for (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1044 A Large-scale Retrospective Study of the Clinical Characteristics of Membranous Lupus Nephritis - L. YANG, G. Ting, T. Ying, Z. Xujie, L. Jicheng, Z. Minghui, Z. Hong Kidney Int Reports
  Lupus nephritis is a common and serious complication of organ involvement in SLE which is mainly manifested by haematuria, proteinuria and decreased renal function, and renal biopsy can classify LN into six pathological types. Proliferative LN (PLN, class III/IV LN), membranous LN (MLN, class V (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1040 A CASE REPORT: THROMBOTIC MICROANGIOPATHY AS A PRESENTATION OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA AND LUPUS NEPHRITIS - C.E. CALDERON GARCIA, G. Navarro Blackaller, A.T. Martínez-Navarro, J.S. Chávez-Iñiguez Kidney Int Reports
  PNH is a rare, acquired entity characterized by intravascular hemolytic anemia with thrombosis and bone marrow failure with pancytopenia, with recurrent episodes of complement-mediated intravascular hemolysis. (Kidney International Reports 8, 3 (2023))
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  WCN23-0969 Mitochondrial DNA Copy Number in Peripheral Blood of IgA Nephropathy: A Cross-sectional Study - J. LIU, R. Wang, N. Luo, H. Mao, Y. Zhou Kidney Int Reports
  Mitochondrial DNA (mtDNA) copy number (CN) is a biomarker of mitochondrial function and has been reported associated with kidney disease. However, its association with IgA nephropathy (IgAN), the most common cause of glomerulonephritis, has not been (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0930 TREATMENT OUTCOME AT SIX MONTHS IN PATIENTS WTIH ANTI-PLA2R ASSOCIATED MEMBRANOUS NEPHROPATHY - M. MAUNG MAUNG, K. Thuyein Lwin, Y. Min Hein, L. Maung Maung, M. Tun Zaw, L. Htet Aung, C. Pyae Aung, M. Aung Hein, Y. Htook Maung, S. Lin, Z. Phyo Hlaing, T. Tin Htay, N. Lin Maung, K. Phyu Pyar Kidney Int Reports
  The primary membranous nephropathy (PMN) is the most common cause of nephrotic syndrome in non-diabetic adults. For decades, the modified Ponticelli regimen was the main stay of treatment and treatment monitoring relied on the traditional markers of remission such as proteinuria and serum (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0917 THROMBOTIC MICROANGIOPATHY AND OUTCOMES IN PATIENTS WITH IMMUNOGLOBULIN A NEPHROPATHY IN THAILAND - P. PUAPATANAKUL, T. Kanjanabuch, J. Surintrspanont, K. Iampenkhae, K. Praditpornsilpa, S. EIam-Ong Kidney Int Reports
  Thrombotic microangiopathy (TMA) has been observed in immunoglobulin A (IgA) nephropathy but its prevalence, pathogenesis, and clinical significance remain uncertain. (Kidney International Reports 8, 3 (2023))
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  WCN23-0892 LUPUS NEPHRITIS WITH THROMBOTIC MICROANGIOPATHY RESISTANT TO IMMUNOSUPPRESSION, CASE REPORT - F.M. DE LA VEGA MÉNDEZ, A.E. Oliva Martínez, C.E. Calderón García, J.S. Chávez Iñiguez, M.D.L.L. Alcántar Vallín Kidney Int Reports
  Lupus nephritis, especially grade IV diffuse nephritis, can be complicated by vascular conditions in a wide variety of clinical manifestations and hematological disorders, including thrombotic microangiopathy. It has been reported that patients with hematological complications such as (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0887 Prevalence and Clinical Significance of Anti Phospholipid Antibodies in Biopsy Proven Lupus Nephritis Patients in a suburban tertiary care center - An Interim Analysis - H. SIVAGNANAM, R. v, S.K. P.k, K. Bhaba. V., M. Anand, K. g Kidney Int Reports
  40 to 60 % of Systemic Lups Erythematosus patients have overt findings of Lupus Nephritis at the time of diagnosis.Antiphospholipid antibodies include Anti Beta 2 Glycoprotein antibodies,Anticardiolipin antibodies and lupus anticoagulant.Presence of aPL antibodies are part of the diagnostic (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0844 RITUXIMAB THERAPY FOR PRIMARY MEMBRANOUS NEPHROPATHY : A CLINICAL EVIDENCE - D. PAL, V. Kumar, H.S. Kohli, R. Ramchandran Kidney Int Reports
  In anti-proteinuric refractory primary membranous nephropathy (PMN), the Kidney Disease Improving Global Outcomes (KDIGO) recommends cyclical cyclophosphamide/corticosteroids (CYC/CS) or rituximab as the 1st line therapy. However, the two-year outcome of rituximab-treated patients is (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0723 MOFETIL VS CYCLOPHOSFAMIDE FOR INDUCTION OF REMISSION IN PATIENTS WITH LUPUS NEPHRITIS - R. VILLANUEVA MACEDO, J. Velador Mendoza, T.C. Muñoz Villanueva, J.J. Gutiérrez Pérez, J.S.V. Javier Soto Vargas, R.A. Ayala Cortes, R. Parra Michel, L.A. Salazar Soltero, F.V. Rios Rios, M. Valdez Avendaño, M.G. Montemayor Villacobos, J.A. Vega Lopez de Nava, C.A. Villacencio Lopez, E.A. Ojeda Garcia, J.O. Romero Tafoya Kidney Int Reports
  Lupus nephritis (LN) occurs in up to 61% of Latin American patients. There are three first-line immunosuppressive treatment schemes for remission induction of lupus nephritis activity proposed by KDIGO in its 2020 glomerulopathies treatment guidelines. two regimens based on cyclophosphamide (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0684 INTERIM BIOMARKER ANALYSIS FROM A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE 2 TRIAL OF SIBEPRENLIMAB (VIS649) IN PARTICIPANTS WITH IMMUNOGLOBULIN A NEPHROPATHY - D.T.M. Chan, T. Kanjanabuch, A. Liew, M. Mathur, J. Yarbrough, X. Wang, Y. Suzuki Kidney Int Reports
  Immunoglobulin A nephropathy (IgAN) is the leading cause of primary glomerulonephritis worldwide; up to 40% of patients develop kidney failure within 20 years of diagnosis. Data have shown that the pathogenesis of IgAN is driven by the B cell growth factor, A Proliferation Inducing Ligand (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0683 CLINICAL AND HISTOPATHOLOGICAL PROFILE OF SIX LUPUS NEPHRITIS CASES AT A TERTIARY REFERRAL CENTRE IN DAR-ES-SALAAM, TANZANIA - S. Ghosh MD, S. Jaffer Kidney Int Reports
  Systemic Lupus Erythematosus (SLE) frequently complicates into Lupus Nephritis (LN). At the time of diagnosis, a large proportion of patients with SLE exhibit some form of renal involvement. Even though patients of African origin have a higher incidence of developing lupus nephritis as well as (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0654 KIDNEY LIMITED COMPLEMENT-MEDIATED THROMBOTIC MICROANGIOPATHY– A CHALLENGING CASE - A. CURTO, A. Santos, A.C. Brás, M. Ramos, A. Lima, J. Santos, M. Verdelho, P. Campos, T. Fidalgo, P. Carrilho, R. Theias Manso, A. Serra, F. Domingos Kidney Int Reports
  Complement-mediated thrombotic microangiopathy (CM-TMA) is a rare disease characterized by microangiopathic hemolytic anemia (MAHA), thrombocytopenia and organ injury. The absence of hemolysis and thrombocytopenia is rare. We present a case of kidney limited CM-TMA successfully treated with (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0652 TIP VARIANT OF FOCAL SEGMENTAL GLOMERULOSCLEROSIS IN A PATIENT WITH HIV INFECTION - J.D. DIAZ GARCIA, M.E. Alamilla Sánchez, N.G. Julio César, O.D.C. Díaz Avendaño, I.G. Ramírez Santana, L. López González, E.F. Morales López, R.C. Hernández Hernández Kidney Int Reports
  HIV-associated nephropathy (HIVAN) is the most common cause of chronic kidney disease in HIV patients. However, in recent years the prevalence of other glomerulopathies has been increasing, including non-collapsing focal segmental glomerulosclerosis as the tip (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0646 PROTEINURIA REMISSION AND LONG-TERM RENAL SURVIVAL IN PATIENTS WITH FOCAL SEGMENTAL GLOMERULOSCLEROSIS - D. GARCIA RAMIREZ, H.C. Campos Gil, L.E. Alvarez Rangel Kidney Int Reports
  Focal segmental glomerulosclerosis (FSGS) is the most frequent primary glomerulopathy and the one that most frequently progresses to chronic kidney disease, with a 5-year global renal survival of 74-80%. (Kidney International Reports 8, 3 (2023))
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  WCN23-0642 RENAL GRANULOMA IN ANCA VASCULITIS – AN OBSERVATIONAL STUDY IN A TERTIARY CARE CENTRE - S.S. MOHAKUDA, A. kaul, M. umair, N. prasad, D. bahaduria Kidney Int Reports
  Rapidly progressive glomerulonephritis (RPGN) is the known pattern of renal injury in Anti Neutrophilic Cytoplasmic Antibody (ANCA) vasculitis. The presence of granulomas on renal biopsy in ANCA vasculitis is reported in few case reports/ case series. This study looks at the clinical profile, (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0628 CLINICAL PROFILE AND OUTCOMES OF PATIENTS WITH MEMBRANOUS NEPHROPATHY RESISTANT TO MODIFIED PONTICELLI REGIMEN - G. SENTHILKUMARAN, V. Devi Rajarathinam, C. Muthukumaran BA, J. V s, V. Murugesan, P.K. Devaraju, T. Lamech, S. Ramanathan, S. Palaniselvam, S.S. Alavudeen, N. Gopalakrishnan Kidney Int Reports
  Membranous nephropathy is one of the most common causes of nephrotic syndrome. Among the available treatment options, the tried and tested regimen is the modified Ponticelli regimen. Despite adequate therapy, studies have shown that close to one-quarter of patients fail to attain complete (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0581 TRADITIONAL MEDICATION ASSOCIATED GLOMERULAR DISEASES – A SINGLE CENTRE STUDY - P.K. DEVARAJU, V. Murugesan, C.M. Balasubramanian, G. Senthilkumaran, V.D. Rajarathinam, J. Vs, G. Natarajan, S.S. Alavudeen, S. Palaniselvam, V. Arumugam Kidney Int Reports
  Membranous nephropathy secondary to heavy metal toxicity is known to occur in patients undergoing treatment with traditional Indian medications. Here we studied the different renal pathologies that were identified among patients with a history of intake of traditional Indian (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0578 LONG TERM OUTCOMES OF PATIENTS WITH LUPUS NEPHRITIS - V.D. RAJARATHINAM, G. Senthilkumaran, J. Vs, V. Murugesan, P. Devaraju, C.M. Balasubramanian, G. Natarajan, S. Ramanathan, D. Thanigachalam Kidney Int Reports
  Lupus nephritis (LN) is a frequent complication of Systemic Lupus Erythematosus (SLE) affecting 60% of adult SLE patients, with a considerable impact on morbidity and mortality. There is a paucity of data on the long term outcomes of LN in South India. This study describes the long term (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0577 TWO MUTATIONS IN COMPLEMENT FACTOR H GENE CAUSE ATYPICAL HEMOLYTIC UREMIC SYNDROME (AHUS) - I. PETRAKIS, K. Dermitzaki, C. Pleros, M. Mitrakos, N. Kroustalakis, A. Androvitsanea, D. Lygerou, E. Drosataki, I. Stavrakaki, M. Konidaki, N. Papadakis, S. Maragou, E. Xylouri, I. Zaganas, K. Stylianou Kidney Int Reports
  Atypical hemolytic uremic syndrome is considered a rare disease. It is manifested by a constellation of signs and symptoms involving many organ systems in the context of thrombotic microangiopathy (TMA). Affected patients present with variable degrees of renal insufficiency in an acute or (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0564 OVERLAP ANCA-ASSOCIATED GLOMERULONEPHRITIS AND IGG4-RELATED KIDNEY DISEASE: A CASE REPORT AND LITERATURE REVIEW - W. PAPANRUENG, K. Thammavaranucupt Kidney Int Reports
  A 65-year-old Thai male patient presented with significant weight loss and progressive renal dysfunction for 1 month. He was recently diagnosed allergic rhinitis and multiple mononeuropathy. He had elevated serum creatinine of 5 mg/dl (Baseline creatinine of 1.2 mg/dl), high (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0558 ANCA TITRES ABOVE 1:160 ARE HIGHLY PREDICTIVE OF PAUCI-IMMUNE GLOMERULONEPHRITIS - A. COHEN, T. De Malmanche, K. Lemmert, N. Weerasinghe, T. Myint Kidney Int Reports
  Pauci-immune glomerulonephritis due to antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a common cause of crescentic glomerulonephritis, a rapidly progressive glomerular disease. Despite advances in treatment, rates of mortality and end-stage kidney disease (ESKD) at 3 (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0551 CLINICAL FEATURES AND OUTCOMES OF MORPHOLOGIC VARIANTS OF PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS IN ADULTS: A RETROSPECTIVE COHORT STUDY - N.H. JAFRY, A. Saboor, E. Ahmed, M. Mubarak Kidney Int Reports
  Columbia classification of Focal segmental glomerulosclerosis (FSGS) identified five histological variants. As treatment-induced remission is associated with better long-term survival, it is important to study which type of FSGS variants are more likely to respond to treatment and whether that (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0542 SARS-COV2 ASSOCIATED MINIMAL CHANGE GLOMERULONEPHRITIS LONG-TERM EFFECTS - A.I. Akl, M.M. Fakeeh Kidney Int Reports
  The spread of Sars-cov2 in December 2019 has resulted in an international COVID19 disease curfew. The respiratory system was affected by COVID-19's persistent clinical features. Sporadic renal manifestations in patients may be related to viral load, immune response, or medications (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0534 CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH IDIOPATHIC MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS BASED ON A NEW CLASSIFICATION: A SINGLE CENTER EXPERIENCE - T. TARIQ, S. Ahmed, E. Ahmed, M. Mubarak Kidney Int Reports
  The reclassification of membranoproliferative Glomerulonephritis (MPGN) into immune complex mediated MPGN (IC-MPGN) and C3 glomerulopathy (C3G) based on immunofluorescence (IF), has provided insights into two distinct diseases. Although it’s one of the commonest cause of chronic kidney disease (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0511 CLINICOPATHOLOGICAL FEATURES AND PREDICTORS OF TREATMENT RESPONSE IN BIOPSY-PROVEN LUPUS NEPHRITIS IN AN AFRO-CARIBBEAN POPULATION - L.A. Fisher, J. Wright, R. Thomas-Chen, M. Bromfield Kidney Int Reports
  Jamaica has a predominant African ancestry and a high burden of lupus nephritis (LN), with lupus amongst the three leading causes of End Stage Renal Disease (ESRD). We aimed to describe the clinicopathological features and determinants of treatment response in a cohort of biopsy-proven LN in (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0507 A 10-YEAR EXPERIENCE IN KIDNEY BIOPSY AT A SINGLE CENTRE IN MAURITIUS - D. Ip Min Wan, A.S. Fedally, O. Bheekharry, R.B. Batra Kidney Int Reports
  The leading cause of chronic kidney disease (CKD) in Mauritius is diabetic nephropathy. However, little else is known about its aetiology on the island which has one of the highest rates of CKD in the world. Kidney biopsy is not widely performed with an estimated rate of 8 biopsies pmp/year and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0498 The pathogenesis of glomerular inflammatory mechanism through Apoptosis Inhibitor of Macrophage - R. KATO, Y. Suzuki, H. Suzuki, R. Aoki, A. Koizumi, M. Lee, N. Homma, Y. Fukao, M. Nakayama, Y. Nihei, M. Muto, T. Kano, Y. Makita, T. Miyazaki, S. Arai Kidney Int Reports
  IgA nephropathy (IgAN) is characterized by mesangial deposits of IgA1-containing immune complexes (IC) and often co-deposits with complement 3 (C3). Our previous study demonstrated that apoptosis inhibitor of macrophage (AIM), which stably associates with IgM pentamers in the blood and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0466 PHASE 1 STUDY IN HEALTHY ADULTS OF THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF ALPN-303, A DUAL BAFF/APRIL ANTAGONIST FOR THE TREATMENT OF AUTOIMMUNE GLOMERULONEPHRITIDES - S.R. Dillon, R. Davies, J.D. Lickliter, K. McLendon, K.L. Manjarrez, A. Smith, M.C. Lessig, L. Blanchfield, R.J. Sanderson, A.G. Chunyk, A. Enstrom, T. Blair, H.Z. Hany Zayed, J. LI, S.L. Peng Kidney Int Reports
  B cell activating factor of the TNF family (BAFF) and a proliferation-inducing ligand (APRIL), cytokines which bind and signal through BAFF-R, transmembrane activator and CAML interactor (TACI), and/or B cell maturation antigen (BCMA) on B cells, play overlapping and non-redundant roles in B (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0427 COENZYME Q10 SUPPLEMENTATION IN AN ADULT PATIENT WITH COQ8 MUTATION AND NEPHROTIC SYNDROME ALLEVIATES RENAL FUNCTION DETERIORATION AND REMITS PROTEINURIA - I. Petrakis, K. Dermitzaki, E. Drosataki, C. Pleros, D. Lygerou, K. Korsavas, I. Katsipi, N. Kroustalakis, I. Stavrakaki, M. Mitrakos, M. Konidaki, N. Papadakis, K. Stylianou Kidney Int Reports
  COQ8 is characterized as an atypical mitochondrial kinase that participates in the multi-subunit of the COQ-enzyme and participates in the electron respiratory chain within the mitochondrion. Its ablation causes podocytic dysfunction and proteinuria in experimental nephrotic syndrome. COQ8 (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0422 PAUCI-IMMUNE GLOMERULONEPHRITIS: DOES NEGATIVITY OF ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODIES HAS CLINICAL SIGNIFICANCE? - T. TARIQ, S. Ahmed, E. Ahmed, M. Mubarak Kidney Int Reports
  Pauci-immune glomerulonephritis (PIGN) is commonly associated with the presence of the antineutrophil cytoplasmic antibodies (ANCA) but significant number of patients do not have these antibodies. This negativity is more prevalent especially in Asian population but its significance in relation (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0415 A STUDY OF CORRELATION BETWEEN SEROLOGICAL MARKERS AND HISTOPATHOLOGY OF LUPUS NEPHRITIS - M. S Shetty, S. kannaiah, S. r, K. k k, M. c, S. r Kidney Int Reports
  Known as SLE, systemic lupus erythematosus is an autoimmune condition. There aren't many established and widely used biomarkers for SLE that can be used to monitor inflammation in the lab. Complement activation causes fluctuations in serum C3 and C4, which are widely utilised as clinical (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0405 AN ADAPTIVE, DOSE-EXPLORATION, PHASE 2 TRIAL EVALUATING EFFICACY AND SAFETY OF IPTACOPAN IN COMBINATION WITH STANDARD-OF-CARE WITH AND WITHOUT ORAL CORTICOSTEROIDS IN ACTIVE LUPUS NEPHRITIS - U.K. VELDANDI, H.J. Anders, T.M. Chan, D. Jayne, P. Mahajan, J. Linnik, N.J.A. Webb, M. Meier, B. Rovin Kidney Int Reports
  Lupus nephritis (LN) is a renal manifestation seen in up to 60% of patients with systemic lupus erythematosus. With the current standard of care (SoC: high-dose followed by tapering oral corticosteroids [CS] plus cyclophosphamide or mycophenolate mofetil/sodium [MMF/MPS]) only 30–50% of patients (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0401 PREDICTING HIGH-RISK PATIENTS USING THE INTERNATIONAL IGA NEPHROPATHY RISK PREDICTION TOOL: A PRELIMINARY SINGLE-CENTRE ANALYSIS - N.R.B. ROZI, H.C. Ting, Z.S. Wong, S.H. Ooi, C.C. Chew, S.F. Cheng, Y.W. Lee, A. Hing Wong, C.C. Gan, M.B. Jalalonmuhali, W.A.H.B. Wan Md Adnan, C.M. Wong, K.P. Ng, H.B. Pasi, S.K. Lim Kidney Int Reports
  The International IgA Nephropathy Risk Prediction Tool (IgAN-RPT) has been utilized to predict renal progression up to 5 or 7 years after biopsy via histological and clinical risk factors. We reported the preliminary analysis of the renal outcome of IgAN patients in relation to their predicted (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0400 SEEK AND YE SHALL FIND: A CASE OF AA AMYLOIDOSIS SECONDARY TO TUBERCULOSIS IN AN ART NAIVE HIV POSITIVE PATIENT - S. MEEL Kidney Int Reports
  HIV related kidney disease has a wide histological phenotype and has been succinctly categorized depending on the kidney compartment affected in the 2018 KDIGO controversies conference paper. (Kidney International Reports 8, 3 (2023))
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  WCN23-0659THE PRAGMATIC MACHINE LEARNING MODEL TO PREDICT ACUTE KIDNEY REPLACEMENT THERAPY IN CRITICALLY ILL PATIENTS - W. PONGSITTISAK, S. Jaturapisanukul, S. Kurathong, N. Srisawat Kidney Int Reports
  Critically ill patients were associated with severe acute kidney injury (AKI) and acute kidney replacement therapy (AKRT). A better prediction of AKRT could result in better triage, rapid management, and the best outcomes. Hence, some studies try to predict AKRT by clinical risk scores or (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0650 ACUTE KIDNEY INJURY AND MULTIPLE MYELOMA - THE ROLE OF CYTOGENETICS - C. BRANCO, G. Sapinho, J. Vieira, H. Silva, C. Martins, G. Esteves, J. Raposo, J.A. Lopes, N. Rodrigues Kidney Int Reports
  Multiple myeloma (MM) is the 2nd most common haematological neoplasm and a largely heterogeneous in what regards clinical presentation, therapy response and prognosis. Renal impairment related to MM is diagnosed in at least 50% of patients. Recent studies have shown an association between (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0630 RENAL RECOVERY AFTER DELAYED PERCUTANEOUS REVASCULARIZATION: A CASE REPORT - F. MAHMOUD, E. Khater, U. Shaikh Kidney Int Reports
  Renal artery stenosis is a major cause of secondary HTN with an incidence of 1-10%. Other associated complications of renal artery stenosis are chronic kidney disease. Many conditions lead to renal artery stenosis including atherosclerotic disease, fibromuscular dysplasia, renal artery (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0613 ATYPICAL HEMOLYTIC UREMIC SYNDROME AND CMV: CAUSE OR CONSEQUENCE? - B. GIL BRAGA, A.C. Cunha, S. Ventura, A. Campos, J. Santos Kidney Int Reports
  Atypical hemolytic uremic syndrome (aHUS) is a life threatening thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal and/or other organ system impairment due to chronic uncontrolled complement activation. CMV, commonly associated with (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0589 ETHNIC DISPARITY AND DIFFERENCES IN ACUTE KIDNEY INJURY MANAGEMENT AND OUTCOME: A PROSPECTIVE OBSERVATIONAL MULTI-CENTER STUDY - A. Al Sahow, O. AlKandari, A. AlYousef, B. AlHelal, H. AlRajab, A. AlQallaf, Y. Bahbahani, M. AlSharekh, A. AlKandari, G. Nessim, B. Mashal, A. Mazroue, M. ElAbbadi, A. Abdelmoteleb, A. Abdelzaher Kidney Int Reports
  Kuwait has a large expatriate community, representing almost two thirds of the total population of 4,464,100. They are non-citizens with a temporary residency permit and have a limited access to public health care provided by ministry of health compared to Kuwaiti citizens. We examined (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0586 ASSOCIATION BETWEEN BODY BASS INDEX AND PATIENT OUTCOME IN PATIENTS WITH ACUTE KIDNEY INJURY REQUIRING CONTINUOUS RENAL REPLACEMENT THERAPY - E. LEE, Y. Kim, E.J. Ko, J.W. Min, E.S. Koh, B.H. Chung, C.W. Yang, H.D. Kim Kidney Int Reports
  Obesity is known as risk factor of diabetes, hypertension and end stage renal disease (ESRD) and associated with higher mortality in general population. However, there has been controversy over the effect of obesity on patients’ clinical outcomes in critically ill patients. In this study, we (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0530 KIDENY ISCHEMIA-REPERFUSION INDUCES CHOLANGIOCYTE CILIA DISRUPTION AND HEPATIC INJURY VIA OXIDATIVE STRESS - Y.K. HAN, Y.R. Park, G. Jang, H.J. Lim, K.M. Park Kidney Int Reports
  Acute kidney injury (AKI) causes injury of distant organs, which is a serious concern in overcoming AKI. Cilium, which is a microtubule-based organelle that protrudes to the cell surface, involves various cell injury and dysfunction. Cilium of cholangiocyte, an epithelial cell lining (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0337 OLIGURIA AND SEPTICEMIA IN OBSTRUCTIVE JAUNDICE POST COMMON BILE DUCT (CBD) EXPLORATION : A CASE REPORT - M. Hanif, M.N. ANANZA, I.A.A. Sofyan, J.I. Hendrawijaya, A. Sultana, M.I. Chandra, H. Purbayu, W.S. Basuki Kidney Int Reports
  Oliguria can occur postoperatively due to a multifactorial etiology in any surgical obstructive jaundice accompanied by AKI & sepsis. OJ can be present with cholangitis represented by intra & extrahepatic biliary tract modifications. Cholangitis & incidence of septicemia may be (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0324 SEVERE SHIGA-TOXIN INDUCED HAEMOLYTIC URAEMIC SYNDROME WITH WIDESPREAD LYTIC BONE LESIONS REQUIRING ECULIZUMAB - M. CARROLL, L. Blake, S. Sharma Kidney Int Reports
  Shiga-toxin producing Escherichia coli induced haemolytic uraemic syndrome (STEC-HUS) is a thrombotic microangiopathy that manifests with macroangiopathic haemolytic anaemia, thrombocytopaenia, and end organ damage caused by micro-thrombi. It is typically observed in the paediatric population. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0285 Acute Kidney Disease in the Outpatient Setting: A Hidden Burden Detected by the Integrated National and Institutional Electronic Medical Records Exchange Platform - D. CHANG, H.Y. Chiang, M.C. Hsieh, Z.H. Lin, H.C. Yeh, I.W. Ting, C.C. Kuo Kidney Int Reports
  The burden of acute kidney disease in outpatients (AKDOPT) is largely unknown due to fragmented information and subtle presentations. China Medical University Hospital (CMUH) established an AKD Care System (AKDCS) that can integrate data from electronic medical records and National Health (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0260 A CASE OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA PRESENTING AS ACUTE KIDNEY INJURY REQUIRING HEMODIALYSIS - S. SAWHNEY, A. Rana, D. Yadav Kidney Int Reports
  CASE REPORT (Kidney International Reports 8, 3 (2023))
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  WCN23-0259 ACUTE KIDNEY INJURY: ITS INCIDENCE, RISK FACTORS, ETIOLOGY, AND OUTCOME AMONG PATIENTS ADMITTED IN VICENTE SOTTO MEMORIAL MEDICAL CENTER FROM 2015-2019 - D. VILLANUEVA, A. Indo Kidney Int Reports
  Acute kidney injury is an abrupt impairment of the kidney function. Its incidence is increasing worldwide causing higher mortality rate, longer admission days, and high healthcare costs. Risk factors and comorbidities of the patients are associated with increased likelihood of developing acute (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0234 A PROSPECTIVE STUDY ON SPECTRUM OF RENAL DISEASE IN MALIGNANCY - G. JEEMON, K. Ganesh, J. Kumar, A. Abraham, S. Simon Kidney Int Reports
  Renal disease in patients with malignancies constitutes a major source of morbidity and mortality. A variety of renal diseases may be associated with various malignancies.These may be seen in various capacities of cancer care such as obstructive uropathies, tumour lysis syndrome, hypercalcemia, (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0221 COMPARISON OF SERUM SODIUM FOLLOWING INTRAVENOUS FLUID ISOTONIC AND HYPOTONIC SOLUTION IN YOUNGER CHILDREN: A RANDOMIZED CONTROLLED TRIAL - O. SIRIMONGKOLCHAIYAKUL, N. Chongcharoen, Y. Amornchaicharoensuk Kidney Int Reports
  Maintenance intravenous fluids (IVFs) were used to provide supportive care for hospitalized children. During the past decade, evidence has suggested that hypotonic IVFs administration increases the risk of hyponatremia especially in intensive care setting and surgical patients. Currently, a (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0139 Leveraging modern machine learning tools to predict outcomes of in-patient acute kidney injury - H. SELVASKANDAN, T. Gaultney, D. Heath, S. Linfoot, G. Xu Kidney Int Reports
  Acute kidney injury (AKI) complicates 13-18% of hospital admissions. While high profile initiatives, such as DeepMind, have sought to use machine learning to predict AKI, predicting which cases progress to require renal replacement therapy (RRT) remains an unaddressed challenge. Early, reliable (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1210 FIRST REPORTED CASE OF GELLER SYNDROME OUTSIDE NORTH AMERICA. Abstract paid for submission 2022-A-WCN23-1137(200026936629) - S.S. BIN RHASBUDIN SHAH, V. Crawford, L. Williams, A. Gupta Kidney Int Reports
  Geller syndrome is a rare autosomal dominant inherited missense mutation S810L of mineralocorticoid receptor, characterized by worsening hypertension and hypokalaemia during pregnancy. This is thought to be due to upregulation of mutated mineralocorticorticoid receptor by abundant progesterone (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0998 PREECLAMPSIA SYNDROME: PLATELETS AND COMPLEMENT MEMBRANE ATTACK COMPLEX. - D. Moraes, J. Braga da Silveira, I.C. Reinheimer, M.V. Baron, M.R. Hentschke, R. Vieira Pecoits, H.C.V.S. Vieira, A.C. dos Santos, E.Á. Parera, C.F. Vieira, C.M. da Silva, B.E.D.C. Pinheiro, T. Paz Munhoz, M.P.D. Santos, C.E. Poli de Figueiredo Kidney Int Reports
  The hemostatic alterations that occur in preeclampsia suggest that there is increased thrombin generation and complement system activation, increased antiangiogenic factors, and alteration in the total number of platelets and platelet index. This study seeks to evaluate the platelet system and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0758 PREGNANCY-RELATED ACUTE KIDNEY INJURY – AN 8 YEAR STUDY FROM SOUTH INDIA - D. BANTEWAD, M. Yadla Kidney Int Reports
  Pregnancy-related acute kidney injury (PRAKI) is a major cause of maternal and fetal morbidity and mortality in developing countries. With improvement in antenatal and postnatal care, the incidence of PRAKI in India has steadily declined from 22% in 1960s to 9% in 1980s,and further down to 3–7% (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0579 POSTPARTUM ACUTE KIDNEY INJURY IN PAKISTAN - K. SULTAN, Z. maqsood, M.S.R. abbasi Kidney Int Reports
  Post-partum Acute kidney injury is still a huge burden on healthcare system in developing countries while its incidence has decreased in developed countries. Etiology and risk factors of Post-Partum AKI in developing counties are different from developed countries.This study was conducted is (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0494 COMMENCEMENT OF KIDNEY REPLACEMENT THERAPY WITHIN 12 MONTHS AFTER CHILDBIRTH IN AUSTRALIA - E. Hewawasam, S. Jahan, S. Jesudason Kidney Int Reports
  Pregnancy is a ‘stress test’ for the kidney, and this may unmask or accelerate decline of underlying chronic kidney disease (CKD). Literature on commencement of kidney replacement therapy ((KRT), dialysis and transplant) within 12 months after pregnancy is sparse, and therefore we were interested (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0402 SERUM CYSTATIN – C AS A POTENTIAL PREDICTIVE MARKER OF RENAL IMPAIRMENT IN PRE-ECLAMPSIA - T.T. TRAN-THAI, N.B. Chung-thi, A.T. Pham-Kieu, H.S. Nguyen-Phan, T.K. Nguyen Kidney Int Reports
  Pre-eclampsia is a pregnancy-related disorder characterized by hypertension, proteinuria, and edema. Serum cystatin C is a novel marker for the early detection of renal damage in pre-eclampsia. Therefore, the study aimed to determine the average value of renal function indexes and some factors (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0363 PATIENT PERSPECTIVES OF PREGNANCY COUNSELLING AND EDUCATION IN WOMEN WITH KIDNEY DISEASE: AN AUSTRALIAN NATIONAL SURVEY - A. ORSILLO, E. Hewawasam, B. Stallard, S. Jesudason Kidney Int Reports
  Women with CKD may have a medically and psychologically complex journey to parenthood. Previous qualitative research has identified the importance of understanding the perspectives and needs of women with CKD. We investigated the value of pregnancy counselling from the patient standpoint, and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0137 POSTPARTUM ACUTE KIDNEY INJURY: A SINGLE CENTRE STUDY IN A LOW RESOURCE COUNTRY - R.D. Gupta, A.Z.M. Salahuddin, H. ISLAM Kidney Int Reports
  Acute kidney injury (AKI) related to pregnancy is one of the serious diseases in low income countries like Bangladesh. It is associated with high morbidity and mortality including increase chance of both fetal and maternal loss which can be preventable. This study was performedto observe the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0104 PREVALENCE OF CHRONIC KIDNEY DISEASE AND INCIDENCE OF ACUTE KIDNEY INJURY AFTER PREECLAMPSIA, REPORT FROM A THIRD-LEVEL HOSPITAL IN MEXICO. - A. VILLA, K.P. Villalon Rosiles, J.M. Rodriguez Chagolla Kidney Int Reports
  Preeclampsia is a disease presented during pregnancy characterized by endothelial damage, angiogenic dysfunction, podocyte damage and activation of the Renin Angiotensin Aldosterone System, manifested with hypertension, proteinuria and sometimes renal function impairment such as Acute Kidney (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1144 A STUDY OF ACUTE KIDNEY INJURY IN SNAKE BITE PATIENTS IN SOUTH INDIA - C. THIYAGARAJAN, N. mohamad, P. nagarajan, M. sreenivasan, M. Sellappan, A. kumar, A. chiniwalar, S. balla, T. navaneethan, K. bhavani, P. nateshan murthy Kidney Int Reports
  Man has been aware of snakebite poisoning since ancient times. According to recent estimates, between 1.2 million and 5.5 million snakebite incidents occur year around the world, resulting in 421,000–1,841,000 envenomations and 20,000–94,000 fatalities.Most patients who suffer a poisonous snake (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1130 TUBERCULOSIS OF THE URINARY TRACT: A CASE REPORT WITH A 10-YEAR CASES REVIEW - N. SONGSILP, K. Wongmaneechuchot, R. Leevongsakorn, K. Jintanapramote, D. Wongsawan, P. Gojaseni, P. Chittinandana Kidney Int Reports
  Tuberculosis (TB) is a common endemic disease in tropical countries. However, TB of the urinary tract is diagnosed in only 5-6 % of extrapulmonary TB. Unfortunately, the symptoms are primarily nonspecific, and the diagnosis is often delayed. Therefore, patients usually turn to end-stage kidney (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1067 ACUTE KIDNEY INJURY WITH OLIGOURIC & HYPERKALEMIA IN WEIL’S DISEASE : A CASE REPORT - A. FIKRY, H. Rasyid, H. Kasim, S.R. Zatalia, N. Machmud, A. Albaar, K. Khaerunnisa Kidney Int Reports
  Weil disease or severe form of leptospirosis, is zoonotic disease caused by a microorganism from the genus Leptospira. Leptospirosis is a life-threatening disease, with acute kidney injury (AKI) is one of the most caused. AKI in leptospirosis is usually non-oliguric and hypokalemic. The initial (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0979 INFECTIONS AND ACUTE KIDNEY INJURY IN THE TROPICS: OPPORTUNITIES FOR PREVENTION AND MANAGEMENT - R. Fischer SB PhD Kidney Int Reports
  Acute kidney injuries are a major clinical and public health challenge in the tropics. Delayed or inaccessible clinical evaluation, combined with limited availability of diagnostics and scarcity of life-saving renal therapies are barriers to identification and management of renal insult and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0964 Adoptive Transfer of Group 3 Innate Lymphoid Cells for the Treatment of Urinary Tract Infection - J. LIU, X. Han, W. Chen, Y. Zhou Kidney Int Reports
  Urinary tract infection (UTI) is among the most common infectious disease and contributes to severe kidney damage as well as end stage renal failure. Group 3 innate lymphoid cells (ILC3s) are located in mucosal tissues and contribute to host defense against bacterial infection. How ILC3s (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0789 DENGUE HEMORRHAGIC FEVER WITH FULMINANT HEPATIC FAILURE SUCCESSFULLY MANAGED WITH HIGH-VOLUME THERAPEUTIC PLASMA EXCHANGE: A SECOND CASE REPORT - R. LEEVONGSAKORN, S. Jantorn, P. Chittinandana, S. Yoowannakul, A. Chuasuwan, D. Wongsawan, P. Gojaseni, K. Jintanapramote Kidney Int Reports
  Liver involvement, including elevated liver enzymes or hepatomegaly, is one of the most common complications of dengue infection, but it is typically minor and self-resolving. Acute liver failure occurs in only 0.31-1.11 percent of dengue patients, but it significantly contributes to mortality. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0788 FACTORS INFLUENCING THE OUTCOMES OF PATIENTS WITH ACUTE KIDNEY INJURY DUE TO VIPER BITE - K.T.Y. LWIN, K. Phyu Pyar, N.S. Htun Kidney Int Reports
  Snake bite is an occupational hazard in the rural areas of the tropics. According to the world health organization (WHO), the global annual mortality from snake bite is around 40,000, of which 23 per cent of deaths occur in West Africa, 10 per cent in India, and 20 per cent in South America. In (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0770 ACUTE KIDNEY FAILURE AFTER AVERRHOA BILIMBI INGESTION: A CASE REPORT - N. KANJANASUPHAK, S. Tipsorn, P. Chittinandana, P. Homkrailas, D. Wongsawan, P. Gojaseni, K. Jintanapramote Kidney Int Reports
  Ingestion of plant toxins is a common cause of acute kidney injury (AKI) in tropical regions. In Thailand, bilimbi fruit (Averrhoa bilimbi) is a highly sour fruit that is occasionally eaten raw or substituted for lime or tamarind as a staple. It has high levels of oxalic acid, which could (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0702 COST OF MANAGEMENT OF ACUTE RENAL FAILURE IN NORTHERN TOGO - E.M.Y.Y. AMEKOUDI, S. Kossi, A. Sarakawabalo, T. Yawovi Mawufemo, M. Tabana Kidney Int Reports
  The mortality of acute renal failure can exceed 40%. Beyond the social burden that this implies, it is an economic burden because its management is expensive. In countries with limited resources such as Togo, where health care is the direct responsibility of the patient, it is necessary to (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0689 CARBONYL AND OXIDATIVE STRESS IN DENGUE ASSOCIATED ACUTE KIDNEY INJURY (DAKI) AND OUTCOME IN EASTERN INDIA - P. MUKHOPADHYAY Kidney Int Reports
  Dengue disease has emerged globally as poorly studied the most frequent viral infection transmitted by a mosquito bite leading to death following acute kidney injury (AKI).It is believed that >50 million people residing in tropical areas worldwide are infected with the dengue virus every (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0413 COMPARISON OF RISK FACTORS, CLINICAL CHARACTERISTICS AND SHORT-TERM CLINICAL OUTCOME OF URINARY TRACT INFECTIONS IN CHILDREN CAUSED BY NON- ESBL AND ESBL PRODUCING BACTERIA - S. Govindan MD, S. Ravi, S. Ekambaram, K. Ganesan Kidney Int Reports
  Urinary tract infections (UTIs) are common infections in childhood. Majority of pediatric UTIs are caused by Enterobacteriaceae family. There is recent rise in community acquired UTIs due to extended-spectrum b-lactamase (ESBL)-producing bacteria. Although difficult to treat, whether these (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0226 Prevalence and risk factors of reduced bone mineral density in Systemic Lupus Erythematosus patients - Y. HONG, Y. Yao Kidney Int Reports
  The reported frequency of reduced bone mineral density (BMD) in systemic lupus erythematosus (SLE) patients varies widely, and its related factors remain unclear. We aimed to detect the frequency and possible risk factors of reduced BMD in patients with (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0096 ACUTE KIDNEY INJURY IN CHILDREN HOSPITALIZED IN A SUB-SAHARAN AFRICA HOSPITAL: CLINICAL ETIOLOGICAL AND PRONOSTIC PROFILE - P.F. KISSOU, A. Semde, A. Sawadogo, J. Dah, M.D. Tchoupé, A. Kouraogo Kidney Int Reports
  The International Society of Nephrology has set the goal of zero preventable deaths due to acute kidney injury(AKI) worldwide by 2025. Nevertheless, situation of childhood acute kidney injury is not yet adequately assessed in health programs in Africa. The aim of this study was to describe the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0068 A CASE SERIES OF FISH BILE INDUCED ACUTE KIDNEY INJURY IN TROPICS - S. SINGH, R. Rungta, P. Sirkanungo, A. Kumar, S. Paul Kidney Int Reports
  Oliguric Acute kidney injury(AKI) caused due to fish bile intake is a proven entity. It has an indolent course with better prognosis than other tropical causes of AKI with histopathological picture of Acute Interstitial Nephritis (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0005 PREVALENCE OF RENAL TUBERCULOSIS IN BRAZIL: 2016 - 2020 - C. Ximenes Feitosa, I.M. Araújo e Silva, B.M. Moreira Aires, M. Leite Rodrigues, A.C. Silva Lima, A.L. Teixeira de Oliveira, M.C. Rebelo Maia, L.T. Pinheiro Medeiros, L.C. Forte Marinho, E. De Francesco Daher, G. Bezerra da Silva Jr Kidney Int Reports
  Tuberculosis (TB) is a chronic infectious and inflammatory disease caused by the Mycobacterium tuberculosis. Renal TB is the third most common form of extrapulmonary TB, which can evolve with progressive kidney damage, from tuberculous pyelonephritis to calcification of the renal parenchyma and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1233 USE OF SECUKINUMAB IN A PATIENT WITH PSORIASIS AND A RECENT DIAGNOSIS OF FABRY DISEASE, PROBABLE RENAL IMPLICATIONS - E.I. RODRÍGUEZ GARCÍA, V. Garcia Mireles, R. Villca Gonzáles, F.G. Hidalgo Alquicira, O.M. Daniel Fernando, J.L. Herrera Acevedo, I. Rivas Bucio Kidney Int Reports
  Fabry disease is a lysosomal storage disease linked to the X chromosome, which involves a defect in the ? -galactosidase enzyme with accumulation of Gb3. Gb3 accumulates in a variety of cells and tissues, including the kidneys. (Kidney International Reports 8, 3 (2023))
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  WCN23-1223 LUPUS NEPHRITIS IN CHILDREN: BANGLADESH PERSPECTIVE - A. Begum, S. Sultana, A. Akter, N. Sultana, S. Sultana, S.M. Santa, D.M.S. Sharmim, A. Al Mamun, T. Jesmin, S. Nahar, S. Huque, R. Ranjan Roy Kidney Int Reports
  Renal involvement is the most important prognostic factor of Systemic Lupus Erythematosus (SLE). Renal involvement, its severity, treatment facilities and outcome varies in different countries. As there is very few data on this regard from this region of the world, we prospectively studied the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1219 LUPUS NEPHRITIS: A SERIES OF 66 CASES FROM A PRIVATE HEALTH CENTER OF THE DOMINICAN REPUBLIC - J. Batista, D. Atizol Rodriguez, I. Madera, H. Pantaleon, E. Dina-Batlle Kidney Int Reports
  Lupus nephritis (LN) is considered the second cause of death in patients with systemic lupus erythematosus (SLE). The disease usually develops 3 to 5 years after the onset of SLE. The onset of LN is usually insidious, causing architectural changes to the kidney without causing any symptoms (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1217 CLINICOPATHOLOGIC CHARACTERIZATION OF FOCAL AND SEGMENTAL GLOMERULOSCLEROSIS IN A DOMINICAN REPUBLIC SAMPLE - H. Pantaleon, M. Almanzar, L. Rojas Perez, E. DINA-BATLLE Kidney Int Reports
  There are limited recent epidemiological and clinicopathological behavior reports on FSGS in the Caribbean population. The aim is to identify clinical characteristic, epidemiological trend and treatment response of patients with diagnosed FSGS and their different variants in a Dominican (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1206 Glomerulopathies Biobank in Uruguay. Description of the first 110 patients enrolled - L. Luzardo, C. Tesore, P. González, C. Ghelfi, M.H. Aunchayna, O. Noboa, G. Ottati Kidney Int Reports
  The incidence of glomerular diseases varies across different countries and criteria for kidney biopsy has changed over time. In Uruguay, glomerular diseases (GD) are a frequent cause of end stage kidney disease (ESKD) and renal replacement therapy with an annual incidence of 25.0 patients per (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1186 PREDICTING DEATH IN ANCA-ASSOCIATED VASCULITIS: A SINGLE-CENTER RETROSPECTIVE STUDY - P. DOMINGUES, A. Inácio, A. Piedade, T. Furtado, P. Valério, A. Farinha, L. Cunha, K. Soto Kidney Int Reports
  The mortality rate of patients with ANCA -associated vasculitis (AAV) is higher than the general population. Systemic AAV has an extremely wide variety of clinical presentation. Predictors of adverse outcomes have not been fully investigated. We aim to identify clinical and laboratory factors (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1174 HISTOPATHOLOGICAL PREDICTORS OF RENAL OUTCOMES IN ANCA-ASSOCIATED VASCULITIDES - A. INÁCIO, P. Domingues, A. Piedade, T. Furtado, B. Mendes, P. Valério, A. Farinha, L. Cunha, K. Soto Kidney Int Reports
  Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are autoimmune systemic diseases with frequent kidney involvement, typically crescentic necrotizing glomerulonephritis. Despite prompt immunosuppressive treatment, over 30% evolve to end-stage kidney disease (ESKD). (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0933 MANAGEMENT OF ESRD IN NEPHROLOGICAL EMERGENCIES AT IBN ROCHD UNIVERSITY HOSPITAL - R. ALAFIFI, C. Maazouzi, C. Soldi, Z. Mohamed, N. Mtioui, S. Elkhayat, G. Medkouri, M. Benghanem Kidney Int Reports
  Chronic kidney disease represents a major public health problem. (Kidney International Reports 8, 3 (2023))
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  WCN23-0923 NOCTURNAL SYSTOLIC BLOOD PRESSURE DIPPING AND PROGRESSION OF CHRONIC KIDNEY DISEASE - C.H. PARK, H.W. Kim, J.T. Park, S.H. Han, S.W. Kang, T.H. Yoo Kidney Int Reports
  Association between nocturnal blood pressure (BP) decline and adverse cardiovascular outcome is well recognized. However, the relationship between diurnal BP profile and the risk of chronic kidney disease (CKD) progression is (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0876 DAPAGLIFLOZIN AND PROGRESSION OF CKD IN PATIENTS WITH AND WITHOUT TYPE 2 DIABETES: PRELIMINARY DATA - I. GRIVEAS Kidney Int Reports
  Globally, diabetes mellitus is a leading cause of kidney disease, with a critical percent of patients approaching end-stage kidney disease. At the same time, Chronic Kidney Disease (CKD) is a major contributor to illness and is associated with impaired quality of life. Until recently, the only (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0750 CHRONIC INTERSTITIAL NEPHRITIS IN AGRICULTURAL COMMUNITIES (CINAC) PREVALENCE IN DIALYSIS PATIENTS OF PARAGUAYabstract paid for submission 2022-A-WCN23-0293(200015357909) - B. Vervaet, W. Cabrera, J. Acosta, J. Battaglia, M. De broe, G. Scheurs, C. Nast, F. Santa Cruz Kidney Int Reports
  CINAC has emerged as a serious health issue with high mortality and morbidity in several geographic areas. Recently we found the typical CINAC tubular lysosomal lesions in the renal biopsy of a 56 years old farmer exposed to pesticides over the last 30 years . The objective of this study is (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0736 KIDNEY INVOLVEMENT IN A GIRL WITH TOWNES–BROCKS SYNDROME - A. KHOKHLOVA, V. Obukhova, L. Prikhodina Kidney Int Reports
  Townes-Brocks syndrome (TBS) (OMIM # 107480) is a rare disease with autosomal dominant inheritance caused by pathogenic variants in the SALL1 gene. TBS is characterized by the triad of imperforate anus, dysplastic ears, and thumb malformations. Minor signs of TBS include hearing loss, foot (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0692 Identification of hub biomarkers and therapeutic agents for renal interstitial fibrosis through bioinformatics analysis and experimental validation - J. LI Kidney Int Reports
  Renal interstitial fibrosis (RIF) is a common histomorphological change associated with end-stage renal disease. However, the underlying mechanisms have not been clarified and available treatments are limited. The aim of this study was to identify potential key genes and therapeutic targets for (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0647 FAMILIAL HYPERURICEMIC INTERSTITIAL NEPHRITIS, A CHALLENGE FOR ETIOLOGIC DIAGNOSIS - A. SANTOS, A.C. Brás, A. Curto, M. Ramos, T. Kmochova, K. Hodanova, M. Zivna, A. Bleyer, S. Kmoch, K. Soto Kidney Int Reports
  Despite increasing knowledge about inherited kidney disorders, monogenic disorders are identified in fewer than 10% of CKD patients. Mitochondrial dysfunction is a major player in the progression of inherited kidney diseases, while mitochondrial-transfer RNA (mt-tRNA) variants and their (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0641 TOWARDS STANDARDIZED HISTOLOGICAL ASSESSMENT CHRONIC INTERSTITIAL NEPHRITIS IN AGRICULTURAL COMMUNITIES: METHODS AND PITFALLS IN MICROSCOPIC DIAGNOSIS - G. Schreurs, C. C Nast, C. Jayasumana, F. Roels, C. Herath, S. Gowrishankar, C. Mousson, R. Dassanayake, C. M Orantes, M. De Broe, B. Vervaet Kidney Int Reports
  Patients with Chronic Interstitial Nephritis in Agricultural Communities (CINAC) demonstrate enlarged lysosomes in the proximal tubular epithelium. These were first discovered in renal biopsies as enlarged argyrophylic granules after Jones’ methenamine silver staining or by autofluorescence. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0626 REVEAL-CKD: PREVALENCE OF UNDIAGNOSED STAGE 3 CHRONIC KIDNEY DISEASE IN ENGLAND - N. Kanumilli, E. Peach, S. Barone, M. Arnold, N. Tangri Kidney Int Reports
  Chronic kidney disease (CKD) is a progressive condition that affects 11.1% of the global population. Early recognition of CKD is vital for effective actions to be taken to slow disease progression and improve patient outcomes. The REVEAL-CKD study aims to assess the prevalence of, and factors (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0625 THE PATIENT JOURNEY FOR IMMUNOGLOBULIN A NEPHROPATHY: DIAGNOSTIC DELAY AND CHANGE IN KIDNEY FUNCTION FROM FIRST CLINICAL SIGN - R. Perkins, E. Swallow, W. Wang, E. Gao, S. Olson, J. Sung, H. Nguyen, D. Peterson, E. Billmyer, A. Chang Kidney Int Reports
  Immunoglobulin A nephropathy (IgAN) commonly presents with hematuria and/or proteinuria; a biopsy is required to confirm diagnosis. This study described time from first clinical sign to biopsy confirmed diagnosis of IgAN and change in kidney function during this (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0612 Interim Results for the Non-Dialytic Chronic Kidney Disease Registry Pilot (CKD-RP) Study - R. Bataclan Kidney Int Reports
  With an increasing prevalence of Chronic Kidney Disease (CKD) in the Philippines, there is a need of looking at data to review effectiveness of management and policies of care among these individuals. While there is an available National Registry for CKD patients who are on renal replacement (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0525 A new therapeutic strategy in severe IgA nephropathy by MP pulse and SVF - B.S. Cho, S.M. Jung, W.H. Cho, H.S. Lee Kidney Int Reports
  One of the most common chronic glomerulonephritis is IgA nephropathy but as yet there is no definitive specific therapeutic means especially when associated with chronic kidney disease, but giving RAAS blocker, omega-3, budesonide, endothelin-A blocker, monoclonal antibodies to inhibit (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0503 Measurement of kidney function in Malawi, South Africa, and Uganda - a multi-centre population cohort study - J. Fabian, R. Kalyesubula, J. Mkandawire, W. Nakanga, J. Prynn, T. Snyman, B. Ssebunnya, E. Musenge, G. Dreyer, J. George, C.H. Hansen, R. Newton, A. Crampin, D. Nitsch, L. Tomlinson Kidney Int Reports
  The burden of kidney disease in many African countries is unknown. Equations used to estimate kidney function from serum creatinine have limited regional validation. We sought to determine the most accurate way to measure kidney function and thus estimate the prevalence of impaired kidney (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0496 COMPARISON OF EGFR USING THE CKD-EPIcrea 2009 AND THE CKD-EPIcrea 2021 EQUATIONS AMONG FILIPINO PATIENTS - R. Tanchanco MD, E. Nuqui, L. Villalobos Kidney Int Reports
  A new creatinine-based estimating equation for glomerular filtration rate (GFR) that does not include race as a coefficient in the formula was released by the Chronic Kidney Disease Epidemiology Study group in 2021. This study was conducted to determine the impact of shifting from the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0483 Machine learning based 2-year Risk Scoring System for Prediction of IgA Nephropathy Progression - J.H. JHEE, H.C. PARK, H.Y. Choi, D. Yoon, Y. Kim, B.J. Lim Kidney Int Reports
  This study aimed to develop a machine learning based 2-year risk prediction model for earlier identification of patients with rapid progressive IgA nephropathy (IgAN) and to assess its performance to predict long-term prognosis of kidney (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0480 CONTRIBUTION OF PHOSPHATE TO THE PATHOGENESIS OF CHRONIC KIDNEY DISEASE IN DOLPHIN - A. Nishiyama MD, N. Jahan Kidney Int Reports
  As humanity enters a super-aging society, the number of patients with chronic kidney disease (CKD) is dramatically increasing. Although the pathophysiology of age-related CKD is likely due to multiple factors, the potential role of phosphate, which accelerates aging, has been recently (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0476 CHRONIC KIDNEY DISEASE SECONDARY TO DIFFERENT CHEMOTHERAPY REGIMENS IN PATIENTS WITH NON-HODGKIN'S LYMPHOMA - M. DE LA GARZA GÁMEZ, L.M. Rizo-Topete, H. Cobos-Aguilar Kidney Int Reports
  Cancer and chronic kidney disease (CKD) represent a serious public health problem in our country, with the advent of new therapeutics for cancer management, the survival of these patients has been prolonged and it is essential to identify their effect at the renal level. The objective was to (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0453 ROLE OF MAGNETIC RESONANCE ELASTOGRAPHY AND BIOMARKERS IN EARLY CHRONIC KIDNEY DISEASE- A HOSPITAL BASED STUDY - M. NAVEEN KUMAR, M. sahay, S. Gowrishankar, S. s Kidney Int Reports
  Fibrosis is the main cause of chronic kidney disease and its progression. Currently, the only means of definitive assessment of fibrosis is by biopsy, an invasive procedure that samples approximately 1% of the kidney. The invasiveness coupled with its small sampling size and the risk of (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0450 ALPORT SYNDROME: WHEN SHOULD WE START NEPHROPROTECTIVE THERAPY? - M. Aksenova, N. Konkova, O. Piruzeeva, T. Lepaeva, N. Zaikova, T. Nikishina, V. Obuhova Kidney Int Reports
  It is well established that angiotensin-converting enzyme inhibitors (ACEi) treatment improves prognosis of patients with Alport syndrome. (Kidney International Reports 8, 3 (2023))
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  WCN23-0447 Precision and Agreement of Glomerular Filtration Rate estimation equations for chemotherapy dosing in cancer patients at St Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia - W.J. Tolossa Kidney Int Reports
  Glomerular Filtration Rate (GFR) is routinely used to quantify kidney function; diagnose and follow kidney dysfunctions. GFR can be measured or estimated using different estimation equations. GFR estimation equations are widely preferred in clinical practice. There are multiple estimation (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0429 COMPARISON OF CREATININE AND CYSTATIN C IN PREDICTING HYPERPHOSPHATEMIA AND HYPERPARATHYROIDISM IN PATIENTS WITH CHRONIC KIDNEY DISEASE - Y. PARK, B. Min, S.H. Yoon, S.R. Yun, W.M. Hwang Kidney Int Reports
  Creatinine (Cr) is the most widely used indicator to predict the glomerular filtration rate (GFR) in the clinical field, but several limitations are presented. Cystatic C (CysC) has been proposed as an alternative to overcome the limitations of Cr, but several limitations are also suggested. As (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0423 High serum leptin level predicted progression of chronic kidney disease: A three-year community based study - P.H. WANG, C.C. Lee, I.W. Wu Kidney Int Reports
  As population ageing, the Chronic Kidney Disease (CKD) becomes more prevalent and causes a burden to our public health system. Obesity was reported to be detrimental to our health, and several adipokines have been proposed to implicate in CKD. However, it’s still unclear how these adipokines (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0421 CHRONIC DEHYDRATION IN RATS INDUCES INJURY PATHWAYS NOT MIMICKING HISTOPATHOLOGY OF CHRONIC INTERSTITIAL NEPHRITIS IN AGRICULTURAL COMMUNITIES (CINAC) Abstract paid for submission 2022-A-WCN23-0467(200017066381) - S. Gerd, M. Stuart, N. Cynthia, D.S.F. Sylvina, D.B. Marc, V. Benjamin Kidney Int Reports
  Chronic Interstitial Nephritis in Agricultural Communities (CINAC) is a form of CKD frequently observed in young farmers (and their families) in (sub)tropical and moderate climates. CINAC-patients can be identified by the recently discovered renal proximal tubular lysosomal lesions which are (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0398 CHRONIC INTERSTITIAL NEPHRITIS IN AGRICULTURAL COMMUNITIES (CINAC) PREVALENCE IN DIALYSIS PATIENTS IN THE FEZ MEKNES REGION IN MOROCCOAbstract paid for submission 2022-A-WCN23-0445(200016925505) - B.K. Zineb, D.B. Marc, M. Fagroud, E. Said, V. Benjamin, S.H. Tarik Kidney Int Reports
  CINAC has emerged as a serious health issue with high mortality and morbidity in several geographic areas. The objective of this study is determination of the prevalence of CINAC in the Fez Meknes region and evaluate associations with different risk factors and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0381 Tenofovir-induced kidney tubular dysfunction and its risk factors among HIV-positive adults in South-Western Nigeria - M. Hassan, R. Duarte, V. Mabayoje, C. Dickens, T. Dix-Peek, A. Lasisi, S. Naicker Kidney Int Reports
  Tenofovir (TDF) is one of the most frequently used anti-retroviral drugs because of its excellent efficacy. However, long-term use of TDF has been associated with proximal kidney tubular dysfunction (KTD). In Nigeria, little is known about the prevalence of tenofovir-induced KTD because it is (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0335 Validation of deep learning integration technology for assisting clinical diagnosis of renal pathologists - Y.L. Huang, F.Y. Jin, Y. Huang, Q. Zhao, Q.Y. Wu, K.L. MA Kidney Int Reports
  The diagnostic grading of renal pathological images depends on the visual evaluation of the professional pathologist. However?it is a very tedious, tiring and visual damage work to repeatedly scan the scattered interested structures in the whole slide images(WSIs) and conduct an accurate (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0330 A deep learning model was established to quantify chronic glomerular lesion using renal biopsy pathologic images - H. Yang, Y.L. Huang, F.Y. Jin, K.L. MA Kidney Int Reports
  Assessing the degree of glomerulopathy is an important step in the process of renal pathological diagnosis, which determines the prognosis and response to treatment of patients. This study aimed to build a robust glomerular segmentation and classification model to quantify chronic (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0321 Risk factors associated with the discordance in kidney function decline rate in identical twins - J.E. Kim MD, J.A. Hwang, J. Shin Kidney Int Reports
  The rate of kidney function decline is different for each individual regardless of any difference in the medical histories. This study set out to identify the risk factors for high discordance in kidney function decline in an identical twin (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0292 COMPARISON OF CKD PREVALENCE USING RACE-FREE CKD-EPI EQUATION (2021) VERSUS CKD-EPI 2009 IN THE THAI GENERAL POPULATION: THE NATIONAL HEALTH EXAMINATION VI SURVEY (2019) - C. Kitiyakara, W. Aekplakorn MD- PhD, S. Chariyalertsak, P. Kessomboon, S. Assanangkornchai, S. Taneepanichskul, N. Neelapaichit Kidney Int Reports
  The 2009 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI 2009) glomerular filtration rate estimation (eGFR) equation had been widely recommended for the assessment of kidney function in the general population and patients with CKD. This equation incorporates coefficients for serum (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0274 ASSOCIATION OF URINE FETUIN-A WITH DIABETIC KIDNEY DISEASE PROGRESSION IN TYPE 2 DIABETES - T. Kanjanabuch, J. Jangsiripornpakorn, C. BOONYAKRAI, W. Umpornwirojkit Kidney Int Reports
  Fetuin-A known as hepatic glycoprotein has been linked to impair renal function. Urinary albumin-to-creatinine ratio (UACR) haven’t been predict reliably on the progression toward advanced chronic kidney disease (CKD). This study aimed to investigate the cross sectional association of urinary (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0272 DIAGNOSTIC TEST FOR CHRONIC INTERSTITIAL NEPHRITIS IN AGRICULTURAL COMMUNITIES (CINAC) Abstract paid for submission 2022-A-WCN23-0308(200015421639) - M. De Broe, B. Vervaet, C. Herath, C. Jayasumana, C. Nast, C. Walter, S. Tarik, J. Belanger, N. Nishanthi Kidney Int Reports
  Lack of a sensitive and specific diagnostic test makes it difficult to come to a correct diagnosis of CINAC (Kidney International Reports 8, 3 (2023))
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  WCN23-0246 THE APPLICATION OF ARTIFICIAL INTELLIGENCE-BASED ANALYTIC RENAL PATHOLOGY SYSTEM IN MCD, FSGS, AND MN - D. LIANG, Q. Lei, X. Liu, W. Jiaping, F. Xu, S. Liang, D. Liang, X. Chu, B. Lv, F. Yang, Y. Ni, G. Xie, C. Zeng Kidney Int Reports
  Analytic Renal Pathology System (ARPS), integrated by several convolutional neural networks, was established to automatically identify the types of glomerular lesions and glomerular intrinsic cells in immunoglobulin A nephropathy (IgAN). This study aimed to evaluate the performance of this (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0235 LONG-TERM EVOLUTION OF KIDNEY FUNCTION IN CHRONIC HEPATITIS C PATIENTS WITH SOFOSBUVIR-BASED OR SOFOSBUVIR-FREE DIRECT-ACTING ANTIVIRALS - M.Y. JIANG, Y.C. Lee, T.H. Lu Kidney Int Reports
  Several studies have shown that direct-acting antiviral (DAA) treatment of hepatitis C virus (HCV) infection has beneficial effects on improving kidney function. However, it remains inconclusive whether sofosbuvir-based and sofosbuvir-free regimens have similar beneficial effects on the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0132 IMPACT OF TUBERCULOSIS ON CHRONIC KIDNEY DISEASE PATIENTS IN THAILAND - C. BOONYAKRAI, A. Pakhakorntanatorn, S. Jirajariyavej Kidney Int Reports
  The combination of chronic kidney disease (CKD) and tuberculosis (TB) endermic area, especially in middle income country like Thailand may have a significant impact on public health. This study sought to evaluation the associations of TB with clinical outcomes in CKD patients. Factor of renal (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0116 CLINICAL CHARACTERISTICS OF CHILDREN WITH CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT AND PREDICTIVE FACTORS FOR CHRONIC KIDNEY DISEASE. ADDIS ABABA ETHIOPIA 2022 - M. Adane, H. Lishan, B.A. BEKELE, D.S. Awoke Kidney Int Reports
  Congenital Anomalies of kidney and Urinary Tract (CAKUT) are the leading causes of chronic kidney disease (CKD) in childhood. Determining the clinical course, outcome, and prognostic factors of this heterogeneous disease group is important to provide appropriate management and follow-up. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0088 PRESENTATION, PROGNOSIS AND OUTCOME OF PATIENTS WITH IGA NEPHROPATHY IN HUNTER REGION, NSW, AUSTRALIA - S. SWAMINATHAN, N. Neelakantan, H. Bryant, P. Rattanamastip, B. Chacko Kidney Int Reports
  IgA Nephropathy remains the most common form of primary glomerulonephritis in the world affecting approximately 200,000-350,000 patients per year globally. In this retrospective cohort study we set out to further characterise IgA Nephropathy and identifying clinical predictors for end stage (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0078 CLINICAL CHARACTERISTICS, RENAL AND OVERALL SURVIVAL IN IMMUNE-COMPLEX MEDIATED MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS VS. C3 GLOMERULOPATHY - K. KAARTINEN PhD, M. Seppälä, A. Räisänen-Sokolowski, S. Meri, E. Honkanen Kidney Int Reports
  Membranoproliferative glomerulonephritis (MPGN) consists of immune-complex - mediated glomerulonephritis (IC-MPGN) and C3 glomerulopathy (C3G). It is not clear if renal and overall prognosis differ between IC-MPGN and C3G. We investigated clinical characteristics, renal and overall survival of (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0075 PROPKD SCORE IN AN ADPKD COHORT- A SINGLE CENTRE EXPERIENCE FROM A DEVELOPING COUNTRY - S. CHANDRASHEKAR, P. Das, S. Singh, C. Devi Kidney Int Reports
  With the longer duration of disease and variable genotype-phenotype expression, it is important to find predictors for the rapid progression of renal failure in ADPKD. The PROPKD score consisting of genetics and clinical parameters is a useful tool in predicting the risk of progression of (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0063 EPIGENETIC REGULATION IN OBESITY AND MATERNAL OBESITY RELATED KIDNEY DISEASE - S. Saad Kidney Int Reports
  Chronic kidney disease (CKD) is a major health burden that is increasing globally at an annual rate of between 6-12%, driven largely by the increased incidence of obesity and diabetes. Metabolic perturbations in the intrauterine environment clearly predispose to CKD, which underpins the notion (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0032 Finerenone is a new addition to renal protection in patients with Type 2 diabetes and chronic kidney disease: A random-effects model meta-analysis - S. GHOSAL, B. Sinha Kidney Int Reports
  The non-steroidal mineralocorticoid antagonist finerenone is a new addition to the list of agents (angiotensin converting enzyme inhibitors, sodium glucose cotransporter 2 inhibitors) conferring renal protection to patient with diabetic kidney disease. Two recent meta-analyses using the fixed (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1059 OUTCOME OF ATYPICAL HEMOLYTIC UREMIC SYNDROME IN ADULT : A SINGLE CENTER STUDY IN TAIWAN - I.R. CHEN, G.J. Wang, C.C. Huang, P.C. Lai, J.G. Chang Kidney Int Reports
  Atypical hemolytic uremic syndrome(aHUS) is a rare and life-threatening disease which characterized by microangiopathy hemolytic anemia, thrombocytopenia, and acute renal failure. Most cases of atypical hemolytic uremic syndrome combine with thrombotic microangiopathy (TMA) to extra-renal (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0993 ACUTE KIDNEY INJURY SECONDARY TO REPERFUSION INJURY IN CRITICAL LIMB ISCHAEMIA: A SUCCESS STORY - S. GOVINDAN, L. Mushahar Kidney Int Reports
  Reperfusion injury is commonly seen post revascularization of critical limb ischaemia. It is a debilitating entity that may cause local complication such as compartment syndrome and systemic complications such as cardiac arrythmia and acute kidney injury (AKI). Here we are reporting a case of (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0954 THE EFFECTS OF MUSCLE MASS AND QUALITY OF PATIENTS WITH ACUTE KIDNEY INJURY REQUIRING CONTINUOUS RENAL REPLACEMENT THERAPY - J. JUNG, J.Y. Park Kidney Int Reports
  Sarcopenia which can lead to decline in physical ability has been known as risk factor on mortality and morbidity. However, little studies have found the effects of muscle mass on mortality of patients with Acute Kidney Injury (AKI) requiring Continuous Renal Replacement Therapy (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0940 SPECTRUM OF INDICATION KIDNEY BIOPSIES IN COMMUNITY ACQUIRED AKI - J. KAUR, J. Sethi, A. Kumar, R. Nada, A. Yadav, V. Kumar Kidney Int Reports
  Community acquired acute kidney injury (CA-AKI) in low income settings is different from that in the high income settings. Infections, poisoning, toxic envenomations and pregnancy related AKI are common. Kidney biopsy is seldom performed in these patients unless atypical clinical course or (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0752 A RARE PRESENTATION OF ACUTE KIDNEY INJURY IN CHRONIC LYMPHOCYTIC LEUKEMIA - N. SHU MIAN, M.S. Fu, W.J. Liu Kidney Int Reports
  Chronic lymphocytic leukaemia (CLL) is one of the common leukaemia in adults. CLL infiltration to kidneys can be a manifestation of worsening of renal function or nephrotic syndrome. However, the mechanisms of acute kidney injury (AKI) with CLL infiltration remained unclear. We reported a case (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0694 THE INCIDENCE, ASSOCIATED FACTORS AND OUTCOMES OF HOSPITALIZED HEART FAILURE PATIENTS WITH ACUTE KIDNEY INJURY AT A SINGLE CENTRE IN JAMAICA - R. BLAIR, L.A. Fisher Kidney Int Reports
  Cardiovascular disease has a high burden in the Caribbean, with heart failure amongst the leading causes of mortality. Although Acute Kidney injury (AKI) is a common and significant complication of heart failure admissions in high-income countries, little is known of its incidence and impact on (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0510 SALT CONSUMPTION AND HIGH BLOOD PRESSURE IN THE POPULATIONS OF NORTHERN SENEGAL - L.N.P. MOTOULA LATOU, S.M. Seck, B. Coundoul Kidney Int Reports
  High blood pressure is worldwide a public health problem, with more than a billion people affected, two-thirds of whom live, according to the WHO, in low and middle-income countries. This study aimed to assess the link between blood pressure and sodium intake in rural populations in central (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0508 PENILE CALCIPHYLAXIS: CASE REPORT AND SYSTEMATIC REVIEW - A. WIPATTANAKITCHAROEN, K. Takkavatakarn, P. Susantitaphong Kidney Int Reports
  Calcified penile artery results in penile calciphylaxis, which is a rare vascular phenomenon and is associated with high morbidity and mortality. The majority of diagnoses of calciphylaxis are clinical. Histopathology reveals small and medium-sized vascular calcifications in the penile (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0493 PREVALENCE OF ARTERIAL STIFFNESS AND ASSOCIATED FACTORS IN THAI HEMODIALYSIS PATIENTS: A CROSS-SECTIONAL MULTICENTER STUDY - N. Naiyarakseree, J. Phannajit, W. Naiyarakseree, T. Thongsricome, N. Mahatanan, P. Asavapujanamanee, S. Lekhyananda, S. Vanichakarn, Y. Avihingsanon, K. Praditpornsilpa, S. Eiam-ong, P. Susantitaphong Kidney Int Reports
  Chronic hemodialysis (HD) patients have higher risks of cardiovascular morbidity and mortality compared with general populations. Cardio-femoral pulse wave velocity (cfPWV) is associated with cardiovascular morbidity and mortality in HD patients. This study aimed to evaluate the prevalence and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0452 SERUM AND URINARY MICRORNA EXPRESSION IN CYNOMOLGUS MONKEYS RECEIVED HIGH SALT DIET - O. Beresneva, M. Zaraiski, M. Parastaeva, G. Ivanova, A. Kucher, E. BOGDANOVA, S. Orlov Kidney Int Reports
  High consumption of NaCl is not only the traditional factor of increase in blood pressure (BP) and cardiovascular risks, but also has a negative impact on kidneys. The mechanisms of the delayed effects of high-salt diets and whether soy proteins can counter the kidney remodeling have not been (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0449 THE CHARACTERISTICS OF HOSPITAL ADMISSIONS IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND HEART FAILURE - S. PARMAR, T. Lopez, R. Shah, M. Khairallah, D. Banerjee Kidney Int Reports
  The prevalence of heart failure (HF) with chronic kidney disease (CKD) is increasing. Both conditions are associated with poor outcomes including fluid overload causing hospitalisations and mortality. Patients with CKD are also less likely to have optimal pharmacological therapies for HF due to (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0436 DECLINE IN GENE EXPRESSION OF PIT1/2 AND DOWNSTREAM SIGNALING PATHWAYS AS AN EARLY MANIFESTATION OF BONE RESPONSE IN MILD KIDNEY INJURY - E. BOGDANOVA, A. Sadykov, G. Ivanova, V. Dobronravov Kidney Int Reports
  Inorganic phosphate (Pi) imbalance and its endocrine and paracrine environment in CKD have an impact on the bone and cardiovascular system recognized as CKD-MBD. In vitro, Pi induces the expression of its transporters PiT1/2 simultaneously with alterations in signal transduction, which are (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0432 OXIDATIVE STRESS AND ANEMIA IN HEMODIALYSIS PATIENTS - F. Bob, M. Chiodan, A. Schiller, L. Petrica, O. Schiller, A. Sircuta, F. Maralescu, M. Bodea Kidney Int Reports
  In chronic kidney disease anemia and oxidative stress are interrelated and their association is associated with poor outcomes. Renal anemia has been shown to trigger accumulation of oxidative products in hemodialysis patients, while correction of anemia may improve oxidative stress status. We (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0384 FIBROBLAST GROWTH FACTORS-23 INCREASE THE RISK OF DEATH IN REGULAR HEMODIALYSIS PATIENTS THROUGH VASCULAR CALCIFICATION (A THREE YEARS COHORT STUDY) - G.W. MAHADITA, K. Yenny, I.G.R. Widiana, N.P. Ayu Kidney Int Reports
  Chronic kidney disease (CKD) is a global issue with rising incidence and mortality rates. The higher incidence of CKD and the growing number of patients requiring renal replacement therapy was associated with a high mortality rate in CKD patients, particularly those undergoing hemodialysis (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0358 PREVALENCE OF VITAMIN D INSUFFICIENCY AND DEFICIENCY AND THE EFFECT OF VITAMIN D SUPPLEMENTS ON LIPID PROFILE IN CHILDREN WITH CKD STAGE 2-4 - Y. THUNSIRIBUDDHICHAI, A. Sumboonnanonda, K. Lomjansook Kidney Int Reports
  Dyslipidemia is a risk factor for cardiovascular disease in children with chronic kidney disease (CKD). Vitamin D deficiency is common in this population and is related to mineral bone disease and other problems in CKD. Vitamin D deficiency was reported to be associated with dyslipidemia in (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0332 PROTEIN ENERGY WASTING AND BODY CELL MASS ASSESSMENT IN CHILDREN WITH CHRONIC KIDNEY DISEASE- A LONGITUDINAL OBSERVATIONAL STUDY - A. Iyengar, R. Kurian Raj, K. Bhat, S. Selvam, A. Vasudevan, A. V Kurpad Kidney Int Reports
  Protein energy wasting (PEW) results from decreased stores of energy and proteins secondary to a maladaptive and hypercatabolic state in chronic kidney disease (CKD). The proposed criteria for diagnosis of paediatric PEW includes anthropometry, biochemical parameters and appetite. Nutritional (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0314 CORONARY ANATOMY IN CHRONIC KIDNEY DISEASE PATIENTS:A PROSPECTIVE ANGIO-GRAPHIC EVALUATION - U. Anandh, S. Bannur, R. Gadepalli Kidney Int Reports
  Chronic kidney disease (CKD) is a leading cause of health disability all over the world and is responsible for premature mortality. This increase in mortality is because of higher incidence of cardiovascular (CV) disease (both atherosclerotic and hypertensive). Hypertensive heart disease is the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0306 KIDNEY FUNCTION IS A DETERMINANT OF BONE LOSS IN PATIENTS WITH MILD TO MODERATE CKD AND BONE BIOPSY PROVEN OSTEOPOROSIS - M. ABDALBARY, M. Nassar, N. Sayed-Ahmed, A. El-Husseini Kidney Int Reports
  CKD is associated with bone loss, however, the effect of GFR decline on bone loss and fractures is not well examined, especially in patients with refractory osteoporosis and early stages of CKD. (Kidney International Reports 8, 3 (2023))
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  WCN23-0302 RELATIONSHIP BETWEEN BLOOD BONE METABOLIC BIOMARKERS AND ANEMIA IN CKD PATIENTS - F. Li, G. Yang, M. Zeng, H. Huang, X. Ye, C. Xing, S. Tang, J. Zhang, Y. Jiang, H. Chen, C. Yin, L. Zhang, Y. Huang, X. Zha, N. Wang Kidney Int Reports
  Renal anemia and chronic kidney disease-mineral and bone disorder (CKD-MBD) are common in patients with chronic kidney disease (CKD). Blood bone metabolic biomarkers are non-invasive indexes for evaluating renal osteodystrophy. Here the relationships between blood bone metabolic biomarkers and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0300 ASSESSMENT OF LEFT VENTRICULAR DIASTOLIC FUNCTION IN VARIOUS STAGES OF CHRONIC KIDNEY DISEASE IN A TERTIARY CARE HOSPITAL IN KERALA - J.A. THARAYIL, A. Sen, J. Kuzhively, H. Abraham Kidney Int Reports
  How soon during course of chronic kidney disease (CKD), left ventricular diastolic dysfunction occurs is a matter of debate. Interaction between left ventricular diastolic function and renal function with preserved systolic function is not well defined in population of (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0298 TRABECULAR BONE SCORE IN ADULTS WITH KIDNEY FAILURE RECEIVING HEMODIALYSIS - S. Phapun, Y. Raruenrom, A. Boonrod, S. Kongpetch, W. Chotmongkol, C. Pongchaiyakul, K. KRITMETAPAK Kidney Int Reports
  Osteoporosis characterized by low bone mineral density (BMD) as measured by dual-energy X-ray absorptiometry (DXA) is common among patients with kidney failure and associates with high fracture risk. In patients with kidney failure; however, the ability of DXA to predict fracture is diminished. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0278 PREVALENCE OF UNDER NUTRITION AMONG MAINTENANCE HEMODIALYSIS PATIENTS IN THE MIDST OF AN ECONOMIC CRISIS - D. Pietersz, S. Kumara, R. Weerakkody, A. Nissanka Kidney Int Reports
  Chronic Kidney Disease (CKD) and nutritional status of a patient is linked in many ways. The prevalence of under-nutrition is higher in developing countries, partly owing to their poor economic status. Sri Lanka is currently facing a huge economic crisis and is in the middle of a diabetes and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0256 OPEN LABEL, NON-INFERIORITY, RANDOMIZED, ACTIVE-CONTROLLED, PHASE III CLINICAL STUDY OF EPOETIN ALFA VERSUS METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA FOR TREATMENT OF ANAEMIA IN CKD NON-DIALYSIS PATIENT - P. Nugroho, K. Rahardjo, J. Sarwono, Y.S. Peng, B.G. Hsu, I.W. Wu, M.L. Chang, C.M. Wong, S.A. Mazlan, P. Vejakama, P. Krisanapan, N. De Asis, T. Situmorang, J. Johnny, S. Roger Kidney Int Reports
  Epoetin Alfa, (Epoetin-Fc fusion protein, GX-E2 or GX-E4), is a novel long-acting recombinant erythropoietin-hybrid fragment crystallizable (Fc) fusion protein that is being developed for the treatment of anaemia associated with non-dialysis CKD (ND-CKD) patients.1 The recombinant glycosylated (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0214 DIALYSIS MALNUTRITION SCORE AND HANDGRIP STRENGTH WITH QUALITY OF LIFE AMONG FILIPINOS ON MAINTENANCE HEMODIALYSIS IN CEBU CITY, PHILIPPINES - J.R. EMPINADO, A.J. Tan, M.K. Woolbright Kidney Int Reports
  Malnutrition is common in hemodialysis patients and is a powerful predictor of morbidity and mortality. End stage renal disease (ESRD) has been shown to negatively affect the Quality of Life (QoL) of patients. Among Chronic Kidney Disease (CKD) patients on maintenance hemodialysis, there is a (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0200 PREVALENCE AND TREATMENT PATTERNS OF ANAEMIA IN INDIVIDUALS WITH CHRONIC KIDNEY DISEASE ACROSS ASIA - D. KIM, J. Lee, T. Toyama, T. Liyanage, M. Woodward, K. Matsushita, L.S. Hooi, M.Y. Lin, K. Iseki, V. Jha, M.G. Wong, M. Jun Kidney Int Reports
  Anaemia is a significant complication of CKD which worsens quality of life, accelerates CKD progression, exacerbates cardiovascular disease, and is associated with increased morbidity and mortality. However, there is limited understanding of the prevalence of anaemia and treatment patterns (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0182 HIGHER SCLEROSTIN IS ASSOCIATED WITH PULMONARY HYPERTENSION IN PRE-DIALYSIS END-STAGE KIDNEY DISEASE PATIENTS: A CROSS-SECTIONAL PROSPECTIVE OBSERVATIONAL COHORT STUDY - J. YANG, H. Young Youl, L. Kyu-Beck, H. Da Seul, K. Hyang Kidney Int Reports
  Pulmonary hypertension (PH) is a complication of chronic kidney disease (CKD) that contributes to mortality. Sclerostin, a SOST gene product that reduces osteoblastic bone formation by inhibiting Wnt/?-catenin signaling, is involved in arterial stiffness and CKD-bone mineral disease, but scanty (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0179 KLOTHO-DERIVED PEPTIDE KP6T AMELIORATES HYPERTENSIVE RENAL AND CARDIAC DISEASE BY TARGETING WNT/?-CATENIN SIGNALING - H. TAN, Y. Liu Kidney Int Reports
  The anti-aging protein Klotho has a protective effect on cardiovascular disease (CVD) and chronic kidney disease (CKD). Due to its large size and complex structure, it is challenging to apply Klotho in clinical usage. Here we report the discovery of a novel Klotho-derived truncated peptide 6 (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0174 ELEVATED SERUM FGF21 IS AN INDEPENDENT RISK FACTOR FOR PNEUMONIA AND ALL-CAUSE MORTALITY IN HEMODIALYSIS PATIENTS FROM TWO LARGE CENTRES: A PROSPECTIVE OBSERVATIONAL STUDY - M. LI, L.Q. Jiang, O. Thorne, M. Yang, B. Wang Kidney Int Reports
  The relationship and the predictive value of serum fibroblast growth factor 21 (FGF21) with all-cause mortality, major adverse cardiovascular events (MACEs) and pneumonia in hemodialysis (HD) patients were assessed. (Kidney International Reports 8, 3 (2023))
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  WCN23-0153 Hematological Parameters of Patients with Chronic Kidney Disease at Initiation of Haemodialysis: Single Centre Experience - P. CHEMUTAI, D. Otieno, E.A. Onyango, S.O. McLigeyo, A.K. Mwango, J. Ngigi, D. Irungu, S.K. Kabinga Kidney Int Reports
  Haematologic abnormalities are common among patients with chronic kidney disease (CKD). The severity of these abnormalities is higher in end-stage kidney disease (ESKD). These are frequently undiagnosed, and untreated resulting in adverse patient outcomes, including death. If diagnosed early, (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0145 DAILY MEDICATION VOLUME OF PHOSPHATE BINDER THERAPIES - S. Sprague, S. Vayalakkada, G. Reddy, S. Gupta, P. Gupta Kidney Int Reports
  Elevated phosphate concentrations are associated with a significantly increased risk of cardiovascular events and mortality in patients with chronic kidney disease.[1] Current KDIGO guidelines recommend lowering elevated serum phosphorus concentrations toward the normal range in patients with (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0123 ANEMIA TREATMENT AND HEMOGLOBIN IN NON-DIALYSIS DEPENDENT CHRONIC KIDNEY DISEASE PATIENTS – A NATIONWIDE HOSPITAL-BASED COHORT STUDY - S. OKAMI, T. Kuragano, S. Tanaka, H. Uenaka, T. Kimura, Y. Ishida, G. James, T. Hayasaki Kidney Int Reports
  Anemia management in non-dialysis dependent chronic kidney disease (NDD-CKD) patients is gaining attention recently with the introduction of new therapeutic agents such as hydroxylase domain enzyme inhibitor (HIF-PHi) in Japan. However, few studies provide comprehensive information on clinical (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0108 EFFECTIVENESS OF LACTOFERRIN IN THE TREATMENT OF ANEMIA IN CHRONIC KIDNEY DISEASE: A SINGLE CENTER PIOLT STUDY EVIDENCE - M. KASHYAP, D. Smita, K. Kekan, M. Premkumar, D. Zohmangaihi, N. Mallik, D. Lad, A. Sharma, S. Sulaiman, I.R. Imran Rather, M.V. Verma, R.S. Jassal, H.S. Kohli Kidney Int Reports
  Anemia is one of the most common complications of chronic kidney disease (CKD). Lactoferrin has shown to be effective treatment for anemia. The data on effectiveness of lactoferrin in the treatment of anemia in CKD is scarce. This real?world pilot study evaluated the effects of lactoferrin with (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0106 IN-VIVO PHOSPHATE REDUCTION: LANTHANUM DIOXYCARBONATE VS LANTHANUM CARBONATE TETRAHYDRATE - A. KHARE, P. Gupta, G. Reddy, S. Gupta Kidney Int Reports
  About 600k kidney failure patients in the US undergo dialysis1. Due to low kidney function, patients often have hyperphosphatemia, which leads to an increased risk of death2. Patients usually rely on dietary restriction and phosphate (P) binders to avoid hyperphosphatemia, but current P binders (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0103 SERUM CALCIUM, PHOSPHATE, AND ALKALINE PHOSPHATASE AS MARKERS OF MINERAL AND BONE INVOLVEMENT IN INCIDENT HAEMODIALYSIS-TREATED ADULTS: A SINGLE-CENTRE OBSERVATION - D. O, E.A. Onyango, S.O. McLigeyo, A. Mwango, J. Ngigi, P. Chemutai, D. Irungu, S. Kabinga Kidney Int Reports
  Chronic kidney disease (CKD) is linked to abnormalities in bone mineralization, strength, and linear growth, with attendant hastened vascular calcification that impacts on cardiovascular morbidity and mortality in patients with end stage kidney disease (ESKD). Mineral and bone disorder is (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0092 LANTHANUM DIOXYCARBONATE EFFECTIVELY REDUCES URINARY PHOSPHATE EXCRETION IN HEALTHY VOLUNTEERS - P. GUPTA, A. Khare, G. Reddy, S. Gupta Kidney Int Reports
  About 600K kidney failure patients in the US undergo dialysis.1 Over 43% of these patients have phosphate (P) >5.5 mg/dL, leading to an increased risk of death.2 Patients rely on dietary restriction and phosphate (P) binders to avoid hyperphosphatemia, but current P binders often do not (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0061 SEVERE HYPERPARATHYROIDISM ASSOCIATED WITH INCREASED FUNCTIONAL AND MOBILITY IMPAIRMENT IN ECUADORIAN HEMODIALYSIS PATIENTS WITH PROLONGED HEMODIALYSIS STAY - J. SANTACRUZ, Á.C. Santacruz Tipanta, L. Báez, P. Arévalo, P.C. Reinoso, A. Vasquez, J.E. Ortiz Rosero Kidney Int Reports
  Secondary hyperparathyroidism is associated with increased morbidity and mortality in hemodialysis (HD) patients which worsens with long HD stay. Vitamin D, phosphate-binders and calcimimetics are used, however their high cost make them unavailable for some latin-American patients. Few is known (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0037 EFFECT OF DIALYSIS MODALITY AND MEMBRANE PERMEABILITY ON FGF 23 LEVEL AND CARDIOVASCULAR CALCIFICATION IN ESRD PATIENTS - F. AHMED, H. Elsayed, W. Beshary, K. Rezk, M. Aboalkair Kidney Int Reports
  Cardiovascular (CV) events are tightly related to the CKD population, with a high incidence of sudden cardiac death, arrhythmia, congestive heart failure, and stroke. Vascular calcification progression and severity are directly associated with these CV events and their related mortality due to (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0036 Elderly, female gender and prolonged hemodialysis stay related with pathological body composition bioimpedance in Ecuadorian hemodialysis patients - K. Armijo, J. SANTACRUZ, C. Santacruz, P. Reinoso, A. Vasquez, L. Baez, V. Gavilanes, N. Noguera Kidney Int Reports
  Hemodialysis (HD) patients are exposed to multiple nutritional and volume disturbances states. Bioimpedance Spectroscopy (BIS) allows analysis of nutritional and hydration status in HD patients, allowing an accurate nutritional diagnosis and dry-weight adjustment. Few is known in Latin-American (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0010 RETROSPECTIVE COMPARATIVE STUDY OF THE SHORT AND LONG TERM OUTCOMES OF PERCUTANEOUS CORONARY INTERVENTION AND CORONARY ARTERY BYPASS GRAFT IN CHRONIC KIDNEY DISEASE POPULATION - A. Shiyam, N. Nishanthi Kidney Int Reports
  Patients with chronic kidney disease are at increased risk of cardiovascular disease and death. For patients with Chronic kidney disease (CKD) and multivessel coronary artery disease (CAD), the optimal revascularization study is still debatable. This is a single center retrospective study to (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1193 PRIMARY HYPER EOSINOPHILIC SYNDROME AS A CAUSE OF CHRONIC KIDNEY DISEASE IN A CHILD – A MISSED OPPORTUNITY TO TREAT BUT A LESSON LEARNT! - K. BALASUBRAMANIAM, D. Rangaswamy Kidney Int Reports
  Primary Hyper-eosinophilic syndrome(HES) is an uncommon condition and extremely rare in the young. It is defined as hyper-eosinophilia(HE) with absolute eosinophilic count(AEC) >1500/?L not due to an underlying cause, along with damage or dysfunction of at least one target organ. The true (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1184 LONG-TERM EFFICACY AND SAFETY OF SPARSENTAN IN YOUNG PATIENTS WITH FSGS: 240-WEEK ANALYSIS OF THE DUET OPEN-LABEL EXTENSION (OLE) - K. LIEBERMAN, A. Paredes, T. Srivastava, R. Komers, E. Murphy, H. Trachtman Kidney Int Reports
  Sparsentan is a novel, oral, non-immunosuppressive, single molecule Dual Endothelin Angiotensin Receptor Antagonist (DEARA) being investigated for focal segmental glomerulosclerosis (FSGS) and immunoglobulin A nephropathy. In the 8-week double-blind period of the phase 2 DUET trial in patients (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1177 Practice patterns of Chronic Kidney Disease Screening and Monitoring in Brazil: A Nationwide Laboratory-based Analysis - M. GUEDES, P. Telles Dias, B. Bezerra Rosa, A. Almeida Senerchia, C. Montenegro, R. Pecoits-Filho, P.[.c. Túlio Monteiro de Castro e Abreu Rocha Kidney Int Reports
  Chronic kidney disease (CKD) requires active screening and monitoring for diagnosis and risk stratification. Access to the population at risk for CKD varies depending on the health care structure and coverage. Practice patterns for CKD screening are largely unknown in middle-income countries (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1152 THE SIGNIFICANCE OF DETERMINING RATIO OF NEUTROPHIL-LYMPHOCYTES AND PLATELET - LYMPHOCYTES IN CHRONIC KIDNEY FAILURE PATIENTS - M. Petrovic, V. Rabrenovic, D. Plicevic, N. Vavic Kidney Int Reports
  Platelet / lymphocyte ratio (PLR) is a marker that represents changes in the number of platelets and lymphocytes due to acute and thrombotic conditions. The value of PLR as an inflammatory marker is higher when compared to another marker, neutrophil-lymphocyte ratio (NLR), which represents the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1122 EVALUATION OF URINARY FETUIN- A FRAGMENT IN PATIENTS WITH TYPE 2 DIABETES AND ITS CORRELATION WITH RENAL FUNCTION AND MICROALBUMINURIA - V.K. BANDI, N.S.S.H. Narilla, S. Chaganti, S. Yarlagadda, S. Eadala Kidney Int Reports
  Fetuin-A is a hepatic secretory glycoprotein that, induces pro-inflammatory cytokines leading to progression of diabetic microvascular and macrovascular complications. Studies have also reported inverse associations of fetuin-A with macrovascular events in diabetics. We investigated the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1088 RISK FACTORS OF CHRONIC KIDNEY DISEASE IN THAI SYSTEMIC SCLEROSIS PATIENTS - S. ANUTRAKULCHAI, R. Apipattarakul, C. Foocharoen, P. Tonsawan, K. Kritmetapak Kidney Int Reports
  Systemic sclerosis (SSc) is a connective tissue disease affecting several internal organs including kidneys. Chronic kidney disease (CKD) is reported to be associated with 3-fold mortality risk in SSc. This study aimed to identify risk factors of CKD in Thai SSc (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1087 SPARSENTAN REDUCES PROTEINURIA IN PATIENTS WITH IMMUNOGLOBULIN A NEPHROPATHY (IGAN): INTERIM RESULTS OF THE PROTECT STUDY - M.G. Wong, H.J. Heerspink, R. Komers, A. Mercer, J. Radhakrishnan Kidney Int Reports
  IgAN is the most common glomerular disease worldwide. Despite optimized standard of care, most patients with IgAN progress to kidney failure within 10-15 years, consequently seriously affecting their quality of life and mortality. Treatments that reduce proteinuria and risk of kidney disease (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1075 Emerging interventions to slow Autosomal Dominant Polycystic Kidney Disease progression: A systematic review - C. Mbobnda, E. Wanko Keutchafo, A. Assounga Kidney Int Reports
  Autosomal dominant polycystic kidney disease is the most prevalent inherited kidney disease, leading to 5-10 % of ESKD. Deeper understanding of the pathophysiological mechanisms of cyst formation and growth has led to the identification of new interventions acting at various levels. Early (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1047 THE PROGNOSIS OF PATIENTS WITH PRIMARY MEMBRANOUS NEPHROPATHY TREATED WITH CALCINEURIN INHIBITORS VS. CYCLOPHOSPHAMIDE: A MULTI-CENTER, REAL-WORLD, RETROSPECTIVE STUDY - Y. ZHANG, J. Xie, Q. Li, W. Yanhui, S. Li, Y.H. Him, S. Zhang, R. Li, J. Li, H. tao, W. Wang Kidney Int Reports
  The effect of calcineurin inhibitors (CNIs) vs. cyclophosphamide (CTX) on the prognosis of primary membranous nephropathy (PMN) patients remains to be determined. (Kidney International Reports 8, 3 (2023))
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  WCN23-0956 APPROACH TO EARLY DIAGNOSIS OF CKDu BY ASSESSING AN AT RISK COMMUNITY IN SRI LANKA - S. HEWAPATHIRANAGE, E. Lee, C. Weerakoon, N. Erandika, D. Herath, I. Bandara, N. Pushpakumara, M. Bandara, K. Harold, X. Yu, M. Montez Rath, P. Vlahos, R. Chandrajith, S. Anand, N. Nannayakkara Kidney Int Reports
  Chronic kidney disease of unknown etiology (CKDu) has been a critical health issue among the farming communities of Sri Lanka for decades. Although numerous studies have investigated the causes and progressive factors of the affected individuals, most are cross-sectional or follow cohorts with (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0955 Performance of latest eGFR equations in Indian population - V. Kumar, A.K. Yadav, H.S. Kohli, V. Jha Kidney Int Reports
  Estimating glomerular filtration rate (eGFR) equations have not been extensively validated in Indian population. Preliminary data collected as part of International Society of Nephrology’s (ISN) Clinical Research Program (CRP) had shown that the widely used creatinine based Chronic Kidney (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0122 THE PREVALENCE OF CHRONIC KIDNEY DISEASE (CKD) AND ITS ASSOCIATED RISK FACTORS IN PEOPLE LIVING WITH HUMAN IMMUNODEFICIENCY VIRUS (PLHIV) - R. MOHD, L. Kamaruzaman, P. Ramakrishnan, S.A. Shah, N. Kori, P. Periyasamy Kidney Int Reports
  Despite increasing prevalence of HIV infection globally, their overall survival rate has improved with the advancement of combined antiretroviral therapy (cART). This study was to determine the CKD prevalence in PLHIV, their risk factors, rate of GFR decline especially those treated with (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0077 LEVELS OF ESSENTIAL AND TOXIC ELEMENTS IN SERUM OF PATIENTS WITH CHRONIC KIDNEY DISEASE: A STUDY FROM AN URBAN RENAL CENTER IN A DEVELOPING COUNTRY - A. ANWAR, B. Alam, K.S. Alam, A.A. Chowdhury, S.B. Quraishi, J. Ferdaus, Z. Hossain, A. Mahmud, S. Sarker, R.A. Alam, I.Z. Rahman, S. Rahman, T. Tabassum, M. Kamal, A. Qader Kidney Int Reports
  Deficiencies of essential elements and excesses of potentially toxic elements are common in patients with chronic kidney disease (CKD).In developing nations like Bangladesh; malnutrition is frequent in both the general populace and CKD patients. In addition, considerable amounts of toxic (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0038 THE PREVALENCE AND SEVERITY OF ANXIETY AND DEPRESSION IN PATIENTS UNDERGOING HEMODIALYSIS AT KENYATTA NATIONAL HOSPITAL AND M.P SHAH HOSPITAL IN NAIROBI, KENYA - H. Bagha, T. Kadernani Kidney Int Reports
  The number of patients who are suffering from chronic kidney disease and are undergoing hemodialysis has been on the rise and the percentage increase is only second to that of HIV/AIDS. Apart from the common medical complications that these patients suffer from, they also suffer from (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0030 CLINICO-PATHOLOGICAL CHARATERISTICS AND OUTCOMES OF ADOLESCENTS AND YOUNG ADULTS WITH CHRONIC KIDNEY DISEASE: A SINGLE CENTRE STUDY - Z. BARDAY, N. Wearne, E.S.W. Jones, M. McCulloch, B.J. Davidsion Kidney Int Reports
  Adolescents and young adults [AYA] are important users of the nephrology health care service. Internationally a paediatric sub-specialty has evolved to manage AYA. Worldwide, there is a paucity of data on the spectrum of kidney disease and outcomes in AYA. This study evaluates kidney outcomes, (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1227 THE CORRELATION BETWEEN RETICULOCYTE HEMOGLOBIN EQUIVALENT (RET-He) AND FIBROBLAST GROWTH FACTOR 23 (FGF23) IN PATIENTS WITH CHRONIC KIDNEY DISEASE ROUTINE HEMODIALYSIS - M. Rudiansyah, R. Bandiara, A.H. Martakusumah, R.M.A. Roesli Kidney Int Reports
  The Chronic Kidney Disease (CKD) patients who undergo routine hemodialysis (CKD-5D) often develop complications, such as mineral and bone disease, and iron deficiency anemia. Ferritin and transferrin saturation are parameters to determine iron level until now. Ferritin is a positive acute phase (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1182 SAFETY AND EFFICACY OF SACUBITRIL-VALSARTAN IN CHRONIC KIDNEY DISEASE AND DIALYSIS PATIENTS WITH HEART FAILURE - J. CAIRNS, E. Bonor, D. Banerjee Kidney Int Reports
  Sacubitril valsartan, an angiotensin and neprilysin inhibiter, improves outcome in patients with heart failure, but its role in patients with CKD is unclear. We audited and studied the role of sacubitril valsartan in chronic kidney disease and dialysis patients in our interdisciplinary heart (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1176 A STUDY OF THE ABNORMALITIES OF THYROID FUNCTION TESTS AND THEIR CORRELATION WITH CHRONIC KIDNEY DISEASE STAGES 4 AND 5 - P. BHUWANIA, R. Gala Kidney Int Reports
  Chronic kidney disease affects the pituitary- thyroid axis and peripheral metabolism of thyroid hormones, thereby causing dysfunction of thyroid hormones. This study aims to highlight the correlation between thyroid dysfunction and the staging of chronic kidney (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1157 BLOOD PRESSURE PROFILE IN CHRONIC KIDNEY DISEASE : THE VALUE OF ABPM - D. DHOHA, A. Fekih, M. Hajji, S. Agrebi, S. Barbouch, F. Ben Hamida, E. Abderrahim Kidney Int Reports
  Arterial hypertension (AH) is very common in chronic kidney disease (CKD). When uncontrolled, it is one of the main causes of cardiovascular complications and mortality. (Kidney International Reports 8, 3 (2023))
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  WCN23-1128 Allopurinol for CVD in CKD (AvoiD-CKD): Baseline characteristics from a double blind, randomized controlled trial - V. Kumar, K. Sharma, H.S. Kohli, V. Jha, A. voiD CKD Study Team Kidney Int Reports
  Observational data have shown association of elevated uric acid levels with adverse cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). Some studies have shown short term favorable modulation of vascular function with hypouricemic agents in CKD. However, conclusive (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1110 PROFILE OF ANEMIA AND ITS IMPACT ON QUALITY OF LIFE IN HEMODIALYSIS PATIENTS - S. SITOMPUL, R.A. Muzasti Kidney Int Reports
  Chronic Kidney Disease is a major health problem, associated with mortality, decreased quality of life, and costly health care. Anemia is one of the chronic kidney disease complications and is found in about 80-90% of chronic kidney disease patients who undergo hemodialysis. Anemia is (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1108 PREVALENCE AND DETERMINANTS OF UNDERNUTRITION IN HEMODIALYSIS PATIENTS, IN KINSHASA, THE DEMOCRATIC REPUBLIC OF THE CONGO - J. Lukusa Kabeya, J. Busanga Bukabau, A. Luzayadio Longo, F.P. Musungayi Kajingulu, M.F. Ingole Mboliasa, Y. Nlandu Mayamba, Y. Mompango Engole, V. Momeme Mokoli, N. Mangani Nseka, E. Kiswaya Sumaili Kidney Int Reports
  Knowledge of the factors associated with undernutrition in chronic hemodialysis (HD) patients is essential for proper prevention of this nosological entity. These factors could be different from one region to another due to cultural reasons and/or lack of resources. This study aimed to (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1101 Instantaneous and persistent elevation of serum potassium and progression of chronic kidney disease, a single center-based cohort study - J. Wang, F. Wang Kidney Int Reports
  Hyperkalemia is associated with higher risk of cardiac arrhythmia leading to sudden death among both general population and patients with chronic kidney disease (CKD), with the latter ones more susceptible to the disorder. Nowadays, hyperkalemia can be well handled through effective treatment, (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1095 FACTORS AFFECTING UNSUCCESSFUL RESPONSES OF CINACALCET IN DIALYSIS PATIENTS - C. Chatnarongchai, S. Anumas, P. Tantiyavarong Kidney Int Reports
  Cinacalcet, a calcimimetic drug, is now used to treat secondary hyperparathyroidism in dialysis patients. The treatment response is varied and failure is common. This study aimed to evaluate factors affecting unsuccessful responses of cinacalcet in chronic dialysis patients with secondary (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1070 A STUDY ON COMPARISON OF PRE & POST ECHO CARDIOGRAPHIC EVALUATION OF SYSTOLIC AND DIASTOLIC DYSFUNCTION AND ITS CLINICAL CORRELATION IN PATIENTS UNDERGOING MAINTENANCE HEMODIALYSIS - S. SURESH Kidney Int Reports
  Cardiovascular disease in the haemodialysis population continues to contribute to mortality and morbidity. Disorders of left ventricular geometry and function are highly prevalent and lead to increased mortality in this highly vulnerable population. Left ventricular dysfunction (LVDys), often (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1035 ASSOCIATION OF PRE-DONATION BLOOD PRESSURE WITH BLOOD PRESSURE DURING EARLY POST-DONATION IN LIVING KIDNEY DONORS - E. Tantisattamo, C. Wannaphut, W. Pangkanon, C. Lopimpisuth, P. Lalitnithi, C. Thimphitthaya, N. Chaisrimaneepan, P. Wattanachayakul, P. Naunsilp Kidney Int Reports
  Living kidney donation is associated with post-donation hypertension. We aim to examine the association between pre-donation and post-donation blood pressure (BP) during the early post-donation. (Kidney International Reports 8, 3 (2023))
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  WCN23-0937 TRENDS IN SERUM PHOSPHATE, CALCIUM, AND PARATHYROID HORMONE LEVELS WITH DENOSUMAB TREATMENT ACCORDING TO RENAL FUNCTION - J. LEE, J. young su, L. jung eun Kidney Int Reports
  Osteoporosis and chronic kidney disease (CKD) have both important independent risk factors for fracture. Denosumab is widely used for osteopenia treatment in CKD patients; however, although denosumab generally seems to be safe and well tolerated, there is a lack of data showing changes in (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0934 IDENTIFICATION OF SHARED GENE SIGNATURES AND MOLECULAR MECHANISMS BETWEEN CHRONIC KIDNEY DISEASE AND ULCERATIVE COLITIS - X. HU, Z. Liang, Y. Zhou Kidney Int Reports
  There is a complex interaction between chronic kidney disease (CKD) and ulcerative colitis (UC), but the pathophysiological mechanisms underlying the coexistence of CKD and UC are unclear. This study aimed to investigate the key molecules and pathways that may mediate the co-occurrence of CKD (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0926 ROXADUSTAT VERSUS EPOETIN-ALFA FOR TREATING ANEMIA IN CHRONIC KIDNEY DISEASE PATIENTS ON MAINTENANCE HEMODIALYSIS: A SINGLE-CENTER, OPEN-LABEL, EXTERNAL PILOT RANDOMIZED CONTROLLED TRIAL: THE RETACH STUDY - A. ALIMUL BARI, N.A.S. Begum, N. Farnaz, E. Yousuf, N. Akhter, M.M. Rashid, M.A. Sayed, M.S. Nomany, S.U.Z. Arefin, H.U. Rashid Kidney Int Reports
  Erythropoietin deficiency is the major mechanism of anemia in CKD. Roxadustat is a hypoxia inducible factor (HIF)-prolyl hydroxylase inhibitor. HIF increases the production of endogenous erythropoietin in hypoxic conditions. HIF-prolyl hydroxylase enzyme breaks it down under normal oxygen (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0900 CHRONIC KIDNEY DISEASE IS A KEY RISK FACTOR FOR AORTIC STENOSIS PROGRESSION - A. CANDELLIER, Y. Bohbot, A. Pasquet, M. Diouf, E. Vermes, E. Goffin, M. Gun, F. Peugnet, L. Hénaut, D. Rusinaru, R. Mentaverri, S. Kamel, G. Choukroun, J.L. Vanoverschelde, C. Tribouilloy Kidney Int Reports
  Rapid progression of aortic stenosis (AS) has been observed in patients undergoing dialysis, but existing cross-sectional evidence is contradictory in non–dialysis-dependent chronic kidney disease (CKD). The present study sought to evaluate whether CKD is associated with the progression of AS (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0896 PERIPHERAL NEUROPATHY AND ALL-CAUSE MORTALITY IN INDIVIDUALS WITH CHRONIC KIDNEY DISEASE: RESULTS FROM THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY - J.S. JEONG, J. Lee, Y.R. Kim, K. Ha, M. Han, D.K. Kim, Y.S. Kim, C.S. Lim, J.P. Lee Kidney Int Reports
  Peripheral neuropathy (PN) is a common complication of chronic kidney disease (CKD), especially in diabetic kidney disease. But information on the association between PN and clinical outcomes in CKD is lacking. We investigated the association between PN and all-cause mortality and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0879 STUDY OF THE CORRELATION OF HEPCIDIN AND RETICULOCYTE HEMOGLOBIN EQUIVALENT IN ABSOLUTE AND FUNCTIONAL IRON DEFICIENCY ANEMIA IN CKD PATIENTS - S.K. VASEEKARAN Kidney Int Reports
  Chronic kidney disease (CKD) is a worldwide public health problem, with adverse outcomes of kidney failure, cardiovascular disease (CVD), and premature death. Anemia is an anticipated consequence as renal function declines, and generally begins to develop before ESRD. Functional or true iron (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0853 COMPARISON OF 24H FOOD RECALL AND 24H URINE UREA IN THE ESTIMATION OF DAILY PROTEIN INTAKE IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE - J.L. KWEK, P.W. Yong, N. Kaur, P. Liu, S.H. Teo, M.W.Y. Foo, J.C.J. Choo Kidney Int Reports
  Low protein intake had been shown to reduce rate of kidney function decline, while insufficient protein intake had resulted in malnutrition in chronic kidney disease (CKD) patients. Methods to estimate daily protein intake in CKD patients can be tedious and prone to bias and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0849 Serum Sortilin Associates With Vascular Calcification in Patients with Stage 5 Chronic Kidney Disease - Y. ZHANG, Y. Wang, J. Chen, R. Tang, B. Liu Kidney Int Reports
  To investigate the relationship between serum Sortilin protein and abdominal aortic calcification?AAC? in chronic kidney disease (CKD5) patients. (Kidney International Reports 8, 3 (2023))
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  WCN23-0824 ACTIVATION OF PIEZO1 DOWNREGULATES RENIN IN JUXTAGLOMERULAR CELLS AND CONTRIBUTES TO BLOOD PRESSURE HOMEOSTASIS - X. YANG, L. Wang, S. Luo, Y. Zhou Kidney Int Reports
  The synthesis and secretion of renin in juxtaglomerular (JG) cells are closely regulated by the blood pressure. To date, however, the molecular identity through which JG cells respond to the blood pressure remains unclear. Recent studies identified the nonselective cation channels Piezo1 as a (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0817 VALIDATION OF BLOOD UREA NITROGEN/SERUM CREATININE RATIO EQUATION TO EVALUATE DIETARY PROTEIN INTAKE IN PATIENTS WITH STAGE 1~4 CHRONIC KIDNEY DISEASE AND PROGNOSTIC ASSESSMENT - Q. LI, J. Xie, H. Tao, W. Wang Kidney Int Reports
  Our previous studies have proven that the blood urea nitrogen/serum creatinine (BUN/SCr) can be used to assess the dietary protein intake (DPI) of stable advanced CKD patients. In this research, we aimed to verify the DPI equation developed using BUN/SCr in CKD stage 1~4 patients. Furthermore, (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0813 Evaluation of Coronary Artery Calcification as a Risk factor Of Cardiovascular Disease in Patients with End Stage Kidney Disease at Initiation of Dialysis - T. Bahadure, M. Goyal, A. Varamudy, A. Thakur, R.R. Nair, S. Gadwal, R. Madipalli, S.B. Raju Kidney Int Reports
  Cardiovascular disease (CVD) is a leading cause of death and premature death among patients with chronic kidney disease (CKD) and is strongly linked to calcification in the arteries. Severity of coronary artery calcification (CAC) increases with CKD staging. CAC is a better predictor than other (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0778 SAFETY AND EFFICACY OF INCORPORATING HIGH POTASSIUM FRUITS IN THE DIET OF HEMODIALYSIS PATIENTS - H. KU, O. An, D. Kim, Y. Woo Kidney Int Reports
  The use of low-potassium fruits is common in diets for patients with end-stage kidney disease. The non-drug strategy for selecting high-potassium fruits is hard to improve due to the lack of nutritional data and limited knowledge of existing high potassium foods. Incorporating high-potassium (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0756 HISTONE DEACETYLASE 9 CONTRIBUTES TO VASCULAR CALCIFICATION IN CHRONIC KIDNEY DISEASE - L. XIONG, Q. Xiao, Y. Li, L. Wang, G. Li Kidney Int Reports
  Vascular calcification (VC) is a serious complication of chronic kidney disease (CKD). Unfortunately, there is no effective therapy for VC beyond supportive care due to the complex pathogenesis of VC. Histone deacetylase 9 (HDAC9) could regulate the transdifferentiation of vascular smooth (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0717 Association between plasma uric acid levels and mortality and cardiovascular outcomes according to kidney function. - J.E. Kim MD, J.K. Leah, S.Y. Ahn, G.J. Ko, Y.J. Kwon Kidney Int Reports
  Plasma uric acid levels rise with worsening renal function, but it is not known whether uric acid levels affect the risk of death and cardiovascular disease according to renal function. (Kidney International Reports 8, 3 (2023))
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  WCN23-0680 PREVALENCE OF MINERAL BONE DISEASE IN CHRONIC KIDNEY DISEASE STAGE V PATIENTS ON HEMODIALYSIS - J. GEORGE, R. S.Bhat, K. Gadabanahalli Kidney Int Reports
  Mineral bone disease is a common problem in patients with chronic kidney disease, affecting bone health and also causing cardiovascular morbidity and mortality. The longevity of our dialysis population is increasing and hence the problems with mineral bone disease are also on the rise. Hence it (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0678 Cognitive impairment in elderly patients with chronic kidney disease and its association with immune dysregulation and chronic inflammation - X. GUO, G. Cai, W. Wang, S. Liang Kidney Int Reports
  Cognitive impairment has a high prevalence rate in chronic kidney disease (CKD) patients with dialysis. Abnormal immune response and chronic inflammation accelerate the development of dementia and poor prognosis. This study investigated cognitive impairment in elderly CKD patients without (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0677 RELATIONSHIP BETWEEN BIOCHEMICAL PARAMETERS OF MINERAL BONE DISEASE AND STATIC BONE HISTOMORPHOMETRY IN CHRONIC KIDNEY DISEASE PATIENTS ON HEMODIALYSIS - R. Jhorawat MD, M. Chaturvedy, S.K. Maurya, N.K. Bajpai, M.K. Jangid, P. Elhence, A. Elhence, A.D. Goel, P. Sharma Kidney Int Reports
  The KDIGO recommended CKD–mineral and bone disorder (CKD-MBD) for the systemic disorder of mineral and bone metabolism due to CKD and limited renal osteodystrophy (ROD) for bone morphology associated with CKD. A bone biopsy is the gold standard diagnostic test in ROD that assesses bone turnover, (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0672 DAPRODUSTAT FOR TREATMENT OF ANEMIA OF CKD IN PEDIATRIC PATIENTS: PROTOCOL FOR THE ASCEND-P TRIAL WITHIN A COHORT - T. Hiemstra, J.G. Vick, J.C. Roberts Kidney Int Reports
  Anemia of Chronic Kidney Disease (CKD) affects many children with more advanced CKD, can have a significant impact on quality of life, developmental milestones, and physical activity. The use of erythropoietins that require regular injection can be particularly challenging in children, and oral (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0670 EFFECT OF THE INTEGRATED CARE MODEL ON BLOOD PRESSURE REDUCTION IN HYPERTENSIVE PATIENTS LIVING IN RURAL COMMUNITY: A RANDOMIZED CONTROL TRIAL - T. PANAPUT, S. Anutrakulchai, N. Methakanjanasak, A. Theeranut, U. Cha’on, S. Lertsinudom, N. Panyaek, K. Tungvanichgapong, W. Saenhom, Y. Deeparn Kidney Int Reports
  Hypertension is a major health challenge causing cardiovascular and chronic kidney disease. We designed an integrated care model and aimed to identify its effectiveness for better management of hypertension. (Kidney International Reports 8, 3 (2023))
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  WCN23-0663 Blood pressure circadian rhythm in a black chronic kidney disease population - P.F. KISSOU, M.D. Tchoupé, O. Tata, C. Ate Kidney Int Reports
  People with chronic kidney disease (CKD) are at high risk of developing cardiovascular diseases (CVD) and CVD, in turn, is the leading cause of death among CKD population. A part of traditional risk factors of CVD, non-dipping BP pattern has been associated with CVD risk. The aim of this study (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0620 BONE HISTOMORPHOMETRY-GUIDED TREATMENT AND BONE MINERAL DENSITY CHANGES IN CHRONIC HEMODIALYSIS PATIENTS: A PROSPECTIVE COHORT STUDY - J. PHANNAJIT, P. Luangjarmekorn, T. Khotavivattana, S. Lawalert, S. Udomkarnjananun, S. Tantavisut, K. Kingpetch, L. Wattanachanya, K. Praditpornsilpa, S. Eiam-ong, P. Susantitaphong Kidney Int Reports
  Patients with chronic kidney disease are at risk of fracture which associated with low bone mineral density. Bone histomorphometry remains the gold standard for the diagnosis and classification of renal osteodystrophy (ROD). The natural course of the disease among the ROD subtypes and the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0593 Health-related quality of life in patients with chronic kidney disease in Thailand: The CORE-CKD Study - P. SANGTHAWAN, P. Klyprayong, S.L. Geater, S. Changsirikulchai, C. Kitiyakara Kidney Int Reports
  Chronic kidney disease (CKD) patients experience compromised quality of life, increased morbidity, and mortality. Enhancing health-related quality of life (HRQoL) is increasingly recognized as another important goal in CKD care. The HRQoL among Thai CKD patients has not been extensively (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0573 PROTEIN ENERGY WASTING AND CLINICAL OUTCOMES OF CHILDREN WITH CKD2-5D- A PROSPECTIVE LONGITUDINAL STUDY - S. MADHILETI, S. Selvam, A. Iyengar Kidney Int Reports
  Protein energy wasting (PEW) is an established entity in adults with CKD but is not well studied in children. The burden of PEW has been observed to be higher in Indian children with CKD compared to the chronic kidney disease in children (CKiD) cohort. The impact of PEW on outcomes needs to be (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0552 LOW LEVELS OF 25-HYDROXYVITAMIN D AND HIGH SENSITIVE C-REACTIVE PROTEIN EFFECTS ON VASCULAR CALCIFICATION IN REGULAR HEMODIALYSIS PATIENTS - Y. Kandarini, G.W. Mahadita, S. Herawati, I.M.D. Putra Ayusta, I.G.R. Widiana, N.P. Ayu Kidney Int Reports
  The incidence of chronic kidney disease (CKD) is increasing. The highest cause of mortality in hemodialysis (HD) patients is cardiovascular disease. One of causes of cardiovascular disease is vascular calcification (VC). This study aims to determine whether low 25-Hydroxyvitamin D (25(OH)D) and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0539 ASSESSMENT OF DIETARY ACID LOAD (DAL) IN CHILDREN WITH CKD2-5D- AN OBSERVATIONAL STUDY - S. MADHILETI, S. Collins, A. Iyengar Kidney Int Reports
  Dietary acid load (DAL) which reflects the balance between acid and alkali-containing foods is a modifiable risk factor for metabolic acidosis in CKD. With the paucity of data in the context of children with CKD, this cross-sectional study was undertaken to estimate DAL and determine associated (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0538 STUDY OF THE DEGREE OF MYOCARDIAL DAMAGE IN PATIENTS WITH CHF ASSOCIATED WITH CHRONIC KIDNEY DISEASE AND ATRIAL FIBRILLATION - G. KARIMDJANOVA Kidney Int Reports
  In recent years, a link between chronic heart failure and an increased risk of kidney dysfunction has been revealed. On the other hand, left ventricular hypertrophy is an independent predictor of mortality in patients with chronic kidney disease and depends on many factors. However, few studies (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0520 EFFICACY OF METHOXY POLYETHILENE GLYCOL-EPOETIN BETA (C.E.R.A) IN CHRONIC KIDNEY DISEASE IN PREDIALYSIS CLINIC AT NEPHROLOGY PROGRAM OF SOCIAL SECURITY IN GUATEMALA - C. MAZARIEGOS, V. Sánchez-Polo, E. Cipriano, A. Manchinelli, J. Joachín Kidney Int Reports
  The prevalence of chronic kidney disease (CKD) in Guatemala is high, in the pre-dialysis clinic of our center are treated almost 2500 patients with CKD stages 3, 4 or 5 without dialysis. Renal anemia is well recognized since early stages of CKD, on stage 3 we can saw it, but the prevalence (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0356 HYPOGLYCEMIA AND KIDNEY EVENTS IN PARTICIPANTS WITH TYPE 2 DIABETES AND ATHEROSCLEROTIC CARDIOVASCULAR DISEASE: OBSERVATIONS FROM THE VERTIS CV TRIAL - D. Cherney, F. Cosentino, R. E. Pratley, S. Dagogo-Jack, D.K. McGuire, M. Maldonado, R. Frederich, W. Fu Kidney Int Reports
  Ertugliflozin is an oral selective sodium–glucose cotransporter-2 inhibitor approved for the improvement of glycemic control in adults with type 2 diabetes mellitus (T2DM). The long-term effects of ertugliflozin on cardiovascular and kidney outcomes were assessed in the Evaluation of (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0352 TO STUDY THE EFFECT OF DAPAGLIFLOZIN IN PATIENTS OF CKD WITH AND WITHOUT TYPE 2 DIABETES MELLITUS - N. KAJLA Kidney Int Reports
  Sodium–glucose co transporter 2 (SGLT2) inhibitors decrease glycated hemoglobin levels and have shown favorable effects on kidney and cardiovascular outcomes in large clinical trials involving patients with type 2 diabetes. This favorable hemodynamic effect may also preserve kidney function in (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0350 C-REACTIVE PROTEIN PROMOTES DIABETIC NEPHROPATHY VIA SMAD3 MEDIATED NLRP3 INFLAMMASOME ACTIVATION - Y. WANG, H. Chen, J. Guo, B. Shao, J. Wang Kidney Int Reports
  Diabetic nephropathy (DN) is the leading microvascular complications of diabetic mellitus. Our previous research revealed that C-reactive protein (CRP) enhances DN and acute kidney injury, by exacerbating renal fibrosis or inflammation via Smad3 signaling pathways. The study determined whether (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0281 KIDNEY TRANSCRIPTOMICS PATTERNS PREDICT RAPID PROGRESSION OF DIABETIC KIDNEY DISEASE - D. ACOBA, A. Levin, A. Witasp, P. Greasley, J. Mölne, J. Nyström, A. Wernerson, A. Reznichenko Kidney Int Reports
  Previous cross-sectional transcriptomics studies have shown associations between kidney gene expression and concomitant kidney function in patients with diabetic kidney disease (DKD) as well as in other chronic kidney disease (CKD) etiologies. However, studies of longitudinal design are (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0237 THE EFFECT OF SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITORS ON RENAL FUNCTION AMONG DIABETIC KIDNEY DISEASE PATIENTS IN THAI POPULATION - P. KAEWDOUNGTIEN, T. Chirananthavat Kidney Int Reports
  Diabetic kidney disease (DKD) is the leading cause of chronic kidney diseases in Thailand. Sodium-Glucose Co-Transporter 2 Inhibitors (SGLT2i) is a new class of antidiabetic agents that have renoprotective action beyond glycemic control. However, the efficacy of SGLT2i on renal function among (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0206 IDENTIFICATION OF MITOPHAGY-RELATED GENES IN DIABETIC NEPHROPATHY BASED ON BIOINFORMATIC ANALYSIS - Y.Y. Yang, Z.X. Gao, Z.H. Mao, D.W. Liu, Z.S. Liu, P. WU Kidney Int Reports
  Accumulating evidence indicates that mitophagy is crucial for the development of diabetic nephropathy (DN). However, little is known about the key genes involved. The present study is to identify the potential mitophagy-related genes (MRGs) in (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0192 PROLIFERATIVE GLOMERULONEPHRITIS WITH MONOCLONAL IMMUNOGLOBULIN DEPOSITS (PGNMID) IN A PATIENT WITH DIABETES MELLITUS - G. METSKHVARISHVILI, I. Tchokhonelidze, M. Tsilosani, V. Bijol, N. Babutsidze, T. Kasradze, N. Sarishvili, R. Rusia, G. Gazdeliani, T. Bagashvili, N. Buadze, K. Dalakishvili, K. Kapanadze, N. Khidasheli, T. Khelashvili Kidney Int Reports
  There are still debates about the timing and indications for kidney biopsy in Diabetes. In clinical practice, the rapidly declining kidney function in diabetic patients is often attributed to Diabetes. Unfortunately, the latter leads to misdiagnosis and poor patient (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0175 IMPROVING SGLT-2 PRESCRIBING IN CKD PATIENTS AT A REGIONAL ENGLISH HOSPITAL: A QUALITY IMPROVEMENT PROJECT - A. BROWN, P. Macinnes, E. Wales, R. Ffrench Kidney Int Reports
  A recent trial in the New England Journal of Medicine reported significantly improved cardiovascular mortality, eGFR decline rate and progression to end stage renal failure in patients with chronic kidney disease (CKD) and albuminuria taking dapagliflozin versus placebo. The improvement was (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0136 Combining MR blockers with SGLT2 inhibitors prevent MR blocker-induced hyperkalemia via regulation of TWIK1 and TASK2 in the proximal tubule - M. NAKAMURA, N. Satoh, T. Mizuno, M. Takagi, S. Horita, M. Nangaku Kidney Int Reports
  Nonsteroidal mineralocorticoid receptor blocker (MRBs) have been shown to inhibit diabetic kidney disease (DKD) progression in recent clinical trials, however, hyperkalemia was a concern as an adverse event. Recent studies suggest that potassium-retaining diuretics and renin-angiotensin system (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0081 SODIUM GLUCOSE CO-TRANSPORTER 2 INHIBITORS RANK HIGHER THAN RENIN-ANGIOTENSIN-ALDOSTERONE BLOCKERS AND FINERENONE IN PREVENTING END-STAGE-RENAL DISEASE IN PATIENTS WITH TYPE 2 DIABETES: A NETWORK META-ANALYSIS - S. GHOSAL, B. Sinha Kidney Int Reports
  Type 2 diabetes (T2D) is a leading cause for chronic kidney disease (CKD). Nearly 51% of patients undergoing renal replacement therapy were found to have diabetes. Treatment options to retard the development and progression of end stage renal disease (ESRD) includes good metabolic control, (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0074 ARTIFICIAL INTELLIGENCE-ASSISTED DISCOVERY OF TRANS-OMICS BIOMARKER SIGNATURE THAT REVEALS MOLECULAR MECHANISM INVOLVING INTER-ORGAN COMMUNICATION IN DIABETIC KIDNEY DISEASE - I.W. WU, T.H. Tsai, C.J. Lo, H.K. Sytwu Kidney Int Reports
  Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease worldwide; however, the integration of high-dimensional trans-omics data to predict DKD is rare. (Kidney International Reports 8, 3 (2023))
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  WCN23-0072 Novel and non-invasive prediction model of non-diabetic kidney disease in Type-2 Diabetes Mellitus – Development and External validation - V. VEERANKI, P. Narayan, J. Meyyappan, R.S. Kushwaha, D.S. Bhadauria Kidney Int Reports
  The renal involvement in diabetes could be either due to Diabetes Mellitus(DKD), non-diabetic kidney disease (NDKD) or both. In face of increasing prevalence of Type-2 Diabetes Mellitus(Type-2 DM) and changing epidemiological factors including age, infections and systemic diseases and better (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0050 SODIUM-GLUCOSE CO-TRANSPORTER-2 INHIBITORS BENEFIT “CARDIOVASCULAR DEATH OR HOSPITALIZATION FOR HEART FAILURE” AND NOT MACE IN TYPE 2 DIABETES PATIENTS IRRESPECTIVE OF BASELINE ALBUMINURIA: A META-ANALYSIS - S. GHOSAL, B. Sinha Kidney Int Reports
  The use of sodium glucose co-transporter 2 inhibitor (SGLT-2i) is associated with a significant improvement cardio-renal outcomes in patients with type 2 diabetes (T2D). The p-value for interaction from individual studies seems to suggest that this benefit is independent of the baseline urine (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0043 THE RENAL COMPOSITE BENEFITS ASSOCIATED WITH SODIUM GLUCOSE CO-TRANSPORTER 2 INHIBITOR IS ASSOCIATED WITH BACKGROUND ATHEROSCLEROTIC CARDIOVASCULAR DISEASE AND NOT HEART FAILURE: A META-ANALYSIS - S. GHOSAL, A. Ghosal, S. Ghosal Kidney Int Reports
  The use of sodium glucose co-transporter 2 inhibitor (SGLT-2i) is associated with a significant improvement in the renal composite (decline in eGFR, requirement for renal replacement therapy, or renal death). However, this benefit is demonstrated in a pooled population consisting of patients (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0041 THE RENAL BENEFITS OF SODIUM GLUCOSE CO-TRANSPORTER 2 INHIBITORS MUST BE ASSESSED BASED ON A STANDARDISED DEFINITION OF RENAL COMPOSITE OUTCOMES: A META-ANALYSIS - S. GHOSAL, B. Sinha Kidney Int Reports
  Type 2 diabetes (T2D) is a leading cause for chronic kidney disease (CKD). Nearly 30%-40% of T2D patients develop CKD. Traditionally, good metabolic control and the use of renin-angiotensin-aldosterone-system (RAAS) were the cornerstone of preventing and retarding the progression of CKD. Among (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0006 CRITICAL ROLE OF SERUM RESPONSE FACTOR IN PODOCYTE EPITHELIAL-MESENCHYMAL TRANSITION OF DIABETIC NEPHROPATHY - L. ZHAO, Y. Xu Kidney Int Reports
  To investigate the expression, function and mechanism of serum response factor (SRF) in podocyte epithelial–mesenchymal transition (EMT) of diabetic nephropathy (DN). (Kidney International Reports 8, 3 (2023))
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  WCN23-1226 ASSOCIATED FACTORS OF SLEEP QUALITY AMONG HYPERTENSIVE PATIENTS IN A NORTH SUMATERA REFERRAL HOSPITAL - A. PUTRI, R. Muzasti Kidney Int Reports
  Several studies have reported an association between the abnormal duration of sleep and chronic conditions including hypertension. However, the existing body of evidence is not entirely significant, as insignificant associations between sleep quality and blood pressure (BP) have been found (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1202 PRELIMINARY RESULTS OF AN INVESTIGATION INTO THE RELATIONSHIP BETWEEN FRAILTY AND HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH BOTH CHRONIC KIDNEY DISEASE AND HEART FAILURE - I. Chung, S. HUSSAIN, T. McNally, E. Tumelty, L. Anderson, D. Banerjee Kidney Int Reports
  Chronic Kidney Disease (CKD) and Heart Failure (HF) are lifelong, progressive conditions with significant disease burden worldwide. (Kidney International Reports 8, 3 (2023))
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  WCN23-1191 EARLY MORTALITY (120 days) AMONGST INCIDENT HEMODIALYSIS WITH END STAGE KIDNEY DISEASE IN A SYSTEM OF OUT OF POCKET PAYMENT: A 5 YEAR RETROSPECTIVE STUDY - D.G. TEUWAFEU, D.F. Mafouk Fopa, R. Gobina, M.P. Halle, F.J. Kaze, G. Ashuntantang Kidney Int Reports
  End stage kidney failure (ESKF) is a major public health problem worldwide. Hemodialysis is the principal method in its management, and is associated with high mortality mostly owing to cardiovascular disease (CVD). In Cameroon, data on its predictors is lacking. This study aimed at determining (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1150 EVALUATION OF TOXIC METALS AND ESSENTIAL ELEMENTS IN CKD PATIENTS FROM OWO A SEMI URBAN CITY IN SOUTHERN NIGERIA - O. Ojo, A. Adenuga, O.A. Ojo, O. Ariyo, F. Arogundade, R. Balogun Kidney Int Reports
  Measurement of trace metal concentrations in various human tissues and body fluids can be used as a clinical diagnostic tool, which elucidates the effect of environment and/ or nutrition on the body metal levels. Several studies have demonstrated adverse effects on population health related to (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1091 PREVALENCE OF HYPERTENSION, DIABETES AND CHRONIC KIDNEY DISEASE AMONG HEALTHCARE PROFESSIONALS OF A SPECIALIZED KIDNEY HOSPITAL IN BANGLADESH: SINGLE CENTRE EXPERIENCE - N.A.S. BEGUM, F. Nobi, M.S.U.Z. Arefin, M.S. Nomany, N. Akhter, E. Yousuf, H.U. Rashid Kidney Int Reports
  In Bangladesh, the number of patients with chronic kidney disease (CKD) is increasing day by day. Early identification and reduction of risk factors of CKD, as well as early detection of CKD, would be the most realistic approach to prevent CKD. In our study we aim to screen for CKD and its risk (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1082 EPIDEMIOLOGY OF CHILDHOOD CHRONIC KIDNEY DISEASE IN KAZAKHSTAN: DATA FROM UNIFIED NATIONAL ELECTRONIC HEALTHCARE SYSTEM 2014 – 2018 - M. Khvan, D. Kozhakhmet, Y. Sakko, V. Kim, A. Gaipov Kidney Int Reports
  The epidemiology of childhood chronic kidney disease (CKD) has not been previously evaluated on a country level in Kazakhstan. We analyzed the prevalence, incidence, mortality rate as well as etiology of CKD and factors associated with all-cause (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1065 TRENDS IN PREVALENCE OF CHRONIC KIDNEY DISEASE AND CARDIOVASCULAR RISK FACTORS IN RURAL INDIA: ANALYSIS OF THREE CROSS-SECTIONAL STUDIES - A. Janardhana, S. Hegde, G. Uma, N. Nikath Kidney Int Reports
  Chronic kidney disease is becoming a major public health issue and is a global epidemic. Many studies across the globe have documented an increase in prevalence of CKD with time while some others have demonstrated a plateau. The trends in prevalence of CKD over time has not been hitherto (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1016 CURRENT EPIDEMIOLOGY AND FORECASTING THE TREND OF CHRONIC KIDNEY DISEASE IN KAZAKHSTAN - G. ZHAKHINA, A. Gaipov, K. Mussina, S. Yerdessov, A. Gusmanov, Y. Sakko, D. Syssoyev, V. Kim, Z. Kuanshgaliyeva, D. Turebekov Kidney Int Reports
  According to the results of the Global Burden of Disease Study, in 2017, the global prevalence of chronic kidney disease (CKD) was 9.1%, which was approximately 700 million cases. The prevalence, incidence, and mortality of CKD in Kazakhstan haven’t been studied yet. The aim of this study is to (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0962 INTEGRATED KIDNEY DISEASE DATABASE: TOWARDS COLLECTING DATA IN RESOURCE LIMITED SETTINGS - K. SHARMA, A. Sharma, H.S. Kohli, V. Kumar Kidney Int Reports
  Lack of source documentation leads to incomplete data capture in kidney disease registries. This problem is particularly prevalent in low resource settings as health systems are overburdened with no central mechanisms for electronic data capture across systems or centers. Data are often (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0960 ASSESSMENT OF CAUSES OF DEATH IN A POPULATION REPRESENTATIVE COHORT AT RISK OF CHRONIC KIDNEY DISEASE OF UNKNOWN ORIGIN, USING SmartVA TECHNOLOGY - B. GUMMIDI, V. Jha, O. John, R. Joshi, V. Gautam, R. John Kidney Int Reports
  A high prevalence of chronic kidney disease (CKD) not associated with known risk factors, dubbed as Uddanam nephropathy, has been reported from coastal districts of Andhra Pradesh, India. Over the last decade, over 4500 kidney disease deaths have been reported in the lay press. However, there (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0895 Association of Chromium with CKDand CKDu-Results from case control study from India - M. Atlani, A. Kumar, S.K. Vallamchetla, S.T. Reddy, A. anirudhan, M. mn, R. sharma, R. Ahirwar Kidney Int Reports
  Environmental factors contribute to the pathogenesis of chronic kidney disease(CKD). The toxic effects of heavy metals, have not been completely evaluated. CKD of unknown cause (CKDu) is diagnosed as CKD in absence of diabetes or hypertension.(1).Chromium (Cr) is a industrial contaminant that (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0888 PEDIATRIC NEPHROLOGY RESOURCES IN LOW AND MIDDLE INCOME (LMI) COUNTRIES: A SURVEY FROM THE IPNA PRIORITIES IN LOW RESOURCE COUNTRIES COMMITTEE (LRCC) - R. ERICKSON, N. Kamath, H. Safouh, G. Montini, M. Bonilla-Félix Kidney Int Reports
  There is wide variability in the availability and accessibility to pediatric nehrology care across the resource limited regions in the world. The International Pediatric Nephrology Association – Low resource countries committee (IPNA- LRCC) set out to define the needs in various regions with the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0864 KNOWLEDGE OF RISK FACTORS, PREVENTIVE PRACTICES, AWARENESS, AND ATTITUDE TOWARDS CKD AMONG THE SOMALI POPULATION - H. RAGE, P.K. Jha, S.A. Hirsi, A.A. Mohamed Kidney Int Reports
  CKD is a major global public health problem that can lead to permanent kidney damage and premature mortality. Public awareness and knowledge are essential for preventing and delaying the progression of CKD. There have been limited studies on CKD knowledge in sub-Saharan African countries. There (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0803 EVOLUTION OF FOUR DECADES OF CHRONIC DIALYSIS TREATMENT IN URUGUAY - L. Luzardo, M.L. Ceretta, A. Ferreiro, M.C. González-Bedat Kidney Int Reports
  In Uruguay, chronic dialysis expanded from 1980 onwards thanks to the creation of the National Fund of Resources, an entity that finances high-cost diagnostic and therapeutic procedures. The Uruguayan Dialysis Registry (UDR) is a mandatory registry that includes information of all patients (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0762 EPIDEMIOLOGICAL, CLINICAL AND ANATOMOPATHOLOGICAL ASPECTS OF GLOMERULAR NEPHROPATHY AT IBN ROCHD HOSPITAL - C. MAAZOUZI, R. Alafifi, S. azria, N. Mtioui, S.S. Elkhayat, M. Zamd, G. Medkouri, B. Ramdani, M. Benghanem Kidney Int Reports
  La néphropathie glomérulaire est l'une des principales causes d'insuffisance rénale chronique pouvant être primitive ou secondaire. La ponction biopsie rénale permet de poser un diagnostic précis de la néphropathie permettant ainsi une orientation thérapeutique et une approche (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0686 THE PATIENT-PROVIDER GAP: UNDERSTANDING BARRIERS AND MOTIVATING FACTORS FOR HOME BLOOD PRESSURE MONITORING IN A CKD COHORT - M. Borkum MD, A. Levin, J. Williams, T. Graham, P. Watson, M. Bevilacqua Kidney Int Reports
  Blood pressure (BP) management can decrease morbidity and mortality in chronic kidney disease (CKD) patients. Home blood pressure monitoring (HBPM) is a convenient, effective way to optimize BP control in patients and reduces their target organ disease and adverse clinical outcomes. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0671 BASELINE CHARACTERISTICS OF PATIENTS ENROLLED IN THE DISCOVER CKD PROSPECTIVE STUDY - C. Pollock, J. Jesus Carrero, E. Kanda, R. Ofori-Asenso, H. Chen, J.J. Garcia Sanchez, R. Pecoits-Filho, S. Fishbane, C. Lam, N. Kashihara, D. Wheeler Kidney Int Reports
  DISCOVER CKD (ClinicalTrials.gov identifier: NCT04034992) is an ongoing multi-country non-interventional cohort study designed to characterize the epidemiology of chronic kidney disease (CKD), including describing patient characteristics, clinical management, and practice patterns, and describe (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0668 HANDGRIP STRENGTH AND ALL-CAUSE MORTALITY IN PATIENTS WITH CHRONIC KIDNEY DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF COHORT STUDIES - F. ZHANG, H. Wang, Y. Bai, Y. Zhang, L.Y. Huang, H.C. Zhang Kidney Int Reports
  In observational studies, handgrip strength (HGS), a prognostic marker for healthy aging, has been associated with several chronic disease outcomes. The present systematic review and meta-analysis aimed to determine the quantitative relationship between HGS and the risk of all-cause mortality (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0604 ACUTE AND CHRONIC COMPLICATION PROFILES AMONG PATIENTS IDENTIFIED WITH CHRONIC KIDNEY DISEASE IN ALBERTA, CANADA - D. Lau, E. Shaw, S. McMullen, T. Cowling, K. Witges, E. Amitay, D. STEUBL, L. Girard Kidney Int Reports
  Chronic kidney disease (CKD) poses a substantial burden to patients and the healthcare system. CKD often progresses to end-stage kidney disease and is associated with increased risk of cardiovascular morbidity and mortality, with 10-30 times higher risk than the general population. Individuals (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0576 SOLUBLE UROKINASE RECEPTOR (suPAR) LEVELS AND INCIDENT CHRONIC KIDNEY DISEASE IN STOP-CKDu COHORT - A.K. Yadav, K. Kamboj, M. Kundu, A. Ghosh, J. Oommen, B. Gummidi, V. Kumar, V. Jha Kidney Int Reports
  Available literature from western population suggests an association of soluble urokinase-type plasminogen activator receptor (suPAR) with CKD. There is scarce data regarding the association of of suPAR and incident CKD in general population. In this study we aim to analyse the predictive role (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0572 Chronic kidney disease and associated risk factors in rural South Africa - a population-based cohort study - J. Fabian, M. Gondwe, N. Mayindi, S. Chipungu, A. Wade, P. Gaylard, F.X. Gómez-Olivé, J. George, C. Winkler, L. Tomlinson, S. Naicker Kidney Int Reports
  In many African countries and including South Africa, the true prevalence of chronic kidney disease (CKD) is unknown and associated clinical and genetic risk factors remain understudied. This rural population-based cohort study aimed to investigate CKD prevalence and associated risk factors in (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0568 PREVALENCE AND PROGNOSTIC OF OBESITY-RELATED GLOMERULOPATHY - T. THONGSRICOME, P. Greeviroj, P. Puapatanakul, P. Boonchayaanant, P. Susantitaphong, P. Katavetin Kidney Int Reports
  The prevalence of overweight and obesity is increasing nowadays. Obesity-related glomerulopathy, including proteinuria and glomerular hyperfiltration, might increase the risk of chronic kidney disease. However, the effect of body weight and other clinical factors on renal outcomes is still (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0506 USING TELEMEDICINE COMPARED WITH FACE-TO-FACE VISITS FOR OUTPATIENT MANAGEMENT IN CHRONIC KIDNEY DISEASE PATIENTS: A NON - RANDOMIZED OPEN LABEL CONTROLLED TRIAL - N. APIBANKURUKIT, A. Chuasuwan Kidney Int Reports
  In the recent past, Coronavirus disease 2019 (COVID-19) was a pandemic, and it has had a profound impact on health. Especially patients with kidney disease are at increased risk for morbidity and mortality from COVID-19. Telemedicine is thought to be used for outpatient management in chronic (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0473 EFFECT OF INCREASING WATER INTAKE FOR 3 YEARS ON REPEATED SELF-ASSESSED HEALTH-RELATED QUALITY OF LIFE (HR-QoL) IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD) - P. SAGAR, F. Asghar Vahedi, G. Rangan, PREVENT-ADPKD Investigators Kidney Int Reports
  The PREVENT-ADPKD randomised controlled trial showed that increasing water intake to maintain urine output above 3L/day (compared to 2.5L/day in the control group) for 3 years did not reduce the progression of kidney cyst growth or eGFR decline in ADPKD (Stages 1-3 CKD). The aim of the current (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0441 Patient characteristics and time to discontinuation of different anti-hyperglycemic medications from UK and US routine clinical care: a multi-database descriptive study - D. VIZCAYA, M. Lavallee, R. Herrera, G. James, D. Kosareva, A. Gay, A. Golozar, N. Oberprieler Kidney Int Reports
  Glycemic control is important for patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) to delay progression to kidney failure. With an array of anti-hyperglycemic medications available, there is limited contemporary understanding of treatment heterogeneity in real-world routine (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0437 CHARACTERISTICS OF NON-DIALYSIS CHRONIC KIDNEY DISEASE PATIENTS IN SRI LANKA - THE FIRST ANALYSIS OF THE SRI LANKA RENAL REGISTRY - R. Abeysekera, N. Herath, D. Galabada, A. Beane, C. Kodippily, Y. Perera, S. Amarasinghe, D. Gamage, P. Athapattu, P. De Silva, L. Nazar Kidney Int Reports
  Chronic Kidney Disease (CKD) is a major health problem in Sri Lanka. However, its burden is undocumented and not adequately characterised. Renal registries have great potential to provide robust information for epidemiology, service evaluation and research as demonstrated internationally. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0420 EPIDEMIOLOGY OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE: A SINGLE-CENTER RETROSPECTIVE COHORT - S. TITICHOATRATTANA, W. Kulvichit, S. Mukdavannakorn, N. Boonvisut, J. Phannajit, P. Katavetin, P. Susanthitapong, K. Tungsanga, S. Tungsanga Kidney Int Reports
  Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited kidney disease. Dealing with structural and functional kidney abnormalities, some ADPKD patients have rapid eGFR decline, leading to end-stage kidney disease (ESKD). The predictive tools to identify such patients are (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0399 INCIDENTS OF LATE REFERRAL OF CHRONIC KIDNEY DISEASE IN LAKIPADADA HOSPITAL, TANA TORAJA, SOUTH SULAWESI, INDONESIA - M. KENDENAN, N.T. Rassat Kidney Int Reports
  Chronic Kidney Disease ( CKD) is a recognized noncommunicable disease that contributes to the global disease burden. Studies on late referral (LR) of CKD patients to nephrologist have reported incidents rate of 22-58% according to the definition of LR used. Incidence rate of patients requiring (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0374 ARSENIC TRIOXIDE TREATMENT IN LUPUS NEPHRITIS – IDENTIFYING THERAPEUTIC TARGETS BY BIOINFORMATICS ANALYSIS AND IN VITRO STUDIES - R. XIE, L. Zhu, K.H.J. Sher, D.Y.H. Yap Kidney Int Reports
  Lupus nephritis (LN) is a severe complication in patients with systemic lupus erythematosus (SLE) and is associated with significant patient morbidity and mortality. Preliminary data suggests that low-dose Arsenic Trioxide (ATO) treatment may reduce renal relapses in LN patients, but the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0339 COMPARISON OF QUALITY OF LIFE BETWEEN HEMODIALYSIS AND CONTINOUS AMBULATORY PERITONEAL DIALYSIS PATIENTS USING THE KDQOL-36 IN BAHASA AT HASAN SADIKIN GENERAL HOSPITAL, BANDUNG, INDONESIA - H. SIREGAR, R. Supriyadi, A. Makmun Kidney Int Reports
  Quality of life (QoL) in End Stage Renal Disease (ESRD) patients is an important outcome for both physicians and patients in selecting dialysis modality in hemodialysis (HD) and Continous Ambulatory Peritoneal Dialysis (CAPD). Quality of life between HD patients and CAPD patients were rarely (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0322 PREVALENCE OF KIDNEY DISEASE IN DIABETICS AND HYPERTENSION AT SANJIWANI GIANYAR HOSPITAL BALI - N.W. SRI WARDANI, I.M. Sila Darmana, S. Widodo Kidney Int Reports
  Chronic Kidney disease is a worldwide concern for diabetics and hypertensives, as they are the two majority contributors of end-stage kidney disease and the increasing dialysis vintage. The prevalence of chronic kidney disease in diabetics were 20-50% worldwide. If this disease was diagnosed (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0277 Use of anti-hyperglycemic medications in patients with incident CKD and T2D by CKD severity: a descriptive study using a large US electronic health records database - D. VIZCAYA, G. James, K. Betts, A. Wu, J. Chen, P. Elena, G. Palombo, M. Kubin, S. van Bommel-Wegmann, S. Beeman, N. Oberprieler Kidney Int Reports
  Control of glucose is one of the key targets in the management of patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2D) to prevent progression to kidney failure. Therefore, timely and appropriate selection of therapy is crucial. However, there are restrictions in the use (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0276 PREVALENCE AND RISK FACTORS OF FRAILTY IN PATIENTS WITH CHRONIC KIDNEY DISEASE: A CROSS-SECTIONAL ANALYSIS OF THE PEAKING STUDY - C. Yang, X. Ling, C. Xiao, J. Zeng, R. Duan, X. Qin, H. Hou, F. Lu, G. SU Kidney Int Reports
  Frailty is common and associated with adverse outcomes in patients with several chronic diseases in western countries. The prevalence of frailty remains unclear in patients with chronic kidney disease (CKD). Our study aims to examine the prevalence and risk factors of frailty in patients with (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0245 Klotho-derived Peptide KP6T Ameliorates Vascular Calcification in CKD - L. Youhua Kidney Int Reports
  Vascular calcification (VC) is the major cause of death and cardiovascular events in end-stage renal disease (ESRD) patients. Presently, the therapeutic options for VC in ESRD are limited and often ineffective. Exogenous anti-aging protein Klotho has been demonstrated to lessen aortic (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0240 Assessment of physical activity by ActiGraphGT3X accelerometer and its risk factors in chronic kidney disease patients: a cross-sectional study from the PEAKING cohort - J. ZENG, C. Xiao, Y. Mo, J. Huang, J. He, C. Yang, F. Chen, Q. Wang, S. Chen, Y. Wu, L. Wang, F. Lu, L. Liu, X. Liu, G. SU Kidney Int Reports
  The self-reported level of physical activity (PA) was low in patients with chronic kidney disease (CKD). Few studies evaluate PA in this population using objective assessor. We aim to evaluate the level of PA by ActiGraphGT3X accelerometer and its risk factors in non-dialysis patients with CKD (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0225 PREVALENCE AND PATTERN OF UPPER GASTROINTESTINAL LESIONS IN CHRONIC KIDNEY DISEASE PATIENTS - S. ISLAM, M.A. Kabir, A. ALIMUL BARI, C.K. Ghosh, M.R. Alam, N.T. Khan, N. Tabassum Kidney Int Reports
  Upper gastrointestinal (GI) lesions are more common in chronic kidney disease (CKD) patients compared to the general population. Although the lesions are usually trivial, they may contribute to anemia and increased morbidity, especially in patients on hemodialysis. They become even more (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0217 DISPARITIES IN KIDNEY DISEASE MORTALITY AMONG ASIAN AMERICAN SUBGROUPS - A. Zhong, N. Dang, M. Khunte, K. Shah, L.L. Hsiao Kidney Int Reports
  Asian Americans are the fastest growing racial group in the United States and are at an increased risk of kidney disease, the tenth leading cause of death in the country. However, the degree to which kidney disease mortality varies across Asian American subgroups is unclear, as most estimates (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0186 RATIONALE AND DESIGN OF THE eCONSENT BX: A RANDOMISED CONTROLLED TRIAL EVALUATING VIDEO-ASSISTED ELECTRONIC CONSENT VERSUS STANDARD CONSENT FOR PERCUTANEOUS ULTRASOUND-GUIDED KIDNEY BIOPSY - P.H. França Gois PhD, R.B. Saunderson, M. Wainstein, V. Miao, J. Jefferis, R. Hudson, S. Chandler, K.A. Mallitt, M. Wolley, B. Elford, H. Wu, A. Bonner, H. Healy Kidney Int Reports
  Clinical consent is how clinicians communicate important information to patients so that they can make informed choices about their procedures/treatment. Informed consent respects the ethical principle of patient autonomy and is enshrined in legal and regulatory structures governing how (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0170 RENAL RESISTIVE INDICES AND THEIR ASSOCIATION WITH KIDNEY DISEASE PROGRESSION AND MORTALITY - C. Kharsa, C. Beaini, D. Chelala, M. AOUN Kidney Int Reports
  Renal resistive indices (RRI) are assessed by a doppler ultrasound and have been shown to predict the progression of kidney disease. It is unknown whether these indices would still predict patients’ outcomes if effective therapeutic and preventive measures are followed. This study aims to (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0463 SEQUESTRATION OF NH4+ IN THE GASTROINTESTINAL TRACT BY SZC IN MICE WITH CKD - F. Marmol, M. Badaruddin, A. Baig, M. Ye, J. Wysocki, K. Bamberg, D. Batlle Kidney Int Reports
  Urinary Ammonium (NH4+) excretion is decreased in CKD but very little is known about fecal NH4+ excretion. We have recently shown that Sodium Zirconium Cyclosilicate (SZC), a non-absorbed, non- polymeric inorganic cation-exchanger that selectively captures K+ in the gastrointestinal tract, can (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0407 FUNCTIONAL VALIDATION OF NOVEL PKD GENES IN RENAL CYST FORMATION USING GENE-EDITED HUMAN KIDNEY ORGANOIDS - T. ZHANG, M. Liu, Y. Xia Kidney Int Reports
  Polycystic kidney disease (PKD) is genetic disorder characterized by renal cyst formation, which eventually leads to end-stage renal disease. Autosomal dominant PKD and autosomal recessive PKD represent two major forms of PKD. Mutations in PKD1 or PKD2 account for most ADPKD cases, and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0387 URINE DICKKOPF-RELATED PROTEIN 3 AS A MARKER OF TUBULOINTERSTITIAL FIBROSIS IN PRIMARY GLOMERULONEPHRITIS - S. Thotsiri, C. Janphram, S. Wimolluck, N. Poomjun, S. Worawichawong, C. Kitiyakara Kidney Int Reports
  Dickkopf-related protein 3 (DKK3) is a secreted glycoprotein that has been implicated in the pathogenesis of a variety of diseases. Recent evidence suggests that urinary DKK3 may serve as a potential biomarker for monitoring kidney disease progression and has been shown to be associated with (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0344 VSIG4 ON EPITHELIAL MESENCHYMAL TRANSITION IN ANGIOTENSIN II-INDUCED HK2 CELLS - M. Noh, D.Y. Hur, S.Y. Han MD Kidney Int Reports
  V-set immunoglobulin-domain-containing 4 (VSIG4) and angiotensin II have been reported to contribute to the development and progression of chronic kidney diseases (CKD). However, it is not clear the relation between angiotensin II and VSIG4 in the kidney. In this study, we determined the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0341 GADD45? ameliorated tubulointerstitial injury in diabetic nephropathy via improvement of mitochondrial fatty acid ? oxidation - X.Q. Li, J.X. Zhang, P.P. Chen, L. Li, K.L. MA Kidney Int Reports
  It is well-known that renal tubular epithelial cells play a critical role in the pathogenesis of diabetic nephropathy (DN). Mitochondrial fatty acid ?-oxidation is the major energetic pathway in proximal tubules. GADD45?, a member of the GADD45 family proteins, is involved in various cellular (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0326 EFFECT OF LACTOBACILLUS RHAMNOSUS GG ON GUT-DERIVED UREMIC TOXIN AND GUT MICROBIOME IN NON- DIALYSIS CHRONIC KIDNEY DISEASE PATIENTS: A RANDOMIZED CONTROLLED TRIAL - S. TREEWATCHAREEKORN, S. Tungsanga Kidney Int Reports
  In chronic kidney disease (CKD), uremic toxins are accumulated, promoting pathogenic bacterial overgrowth, causing gut dysbiosis, and inducing gut-derived uremic toxins (GDUT) production, which cause CKD progression. We explored the effects of Lactobacillus rhamnosus GG (GG), a probiotic, on (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0311 INVESTIGATION OF THE ASSOCIATION BETWEEN IRISIN AND SARCOPENIA IN CHRONIC KIDNEY DISEASE - T. Okuma, S. Ueda, H. Nagasawa, T. Otsuka, M. Nakata, K. Sato, Y. Suzuki Kidney Int Reports
  The prevalence of sarcopenia is high in patients with chronic kidney disease (CKD). Further, sarcopenia is reported to be closely associated not only with reduced physical activity but also with mortality. Recently, it has been noticed that skeletal muscles immediately after exercise secrete (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0279 KIDNEY 'PATHWAY ORPHAN' GENES AS A POTENTIAL SOURCE OF NOVEL CHRONIC KIDNEY DISEASE BIOLOGY - D. Acoba, S. Gunnarsson, A. Reznichenko Kidney Int Reports
  While genetic association and omics studies have made huge progress in discovering new genes associated with chronic kidney disease (CKD), mechanistic studies still typically investigate well-known genes and proteins. Many uncharacterized genes remain understudied despite their association to (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0263 HIGH FAT/HIGH SUCROSE FEEDING AGGRAVATES KIDNEY LESIONS IN THE SPONTANEOUSLY DIABETIC TORII FATTY RAT, AN OBESE TYPE 2 DIABETIC MODEL OF NEPHROPATHY - F. BRIAND PhD, K. Watanabe, K. Miyajima, M. Shinohara, T. Ohta, Y. Kageyama Kidney Int Reports
  We have previously characterized the Spontaneously Diabetic Torii (SDT) fatty rat, a novel hypertensive, obese, type 2 diabetic model to evaluate drugs targeting diabetic nephropathy. Since dyslipidemia and renal lipid accumulation are thought to play a role in diabetic kidney disease, we here (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0258 SHORT-CHAIN FATTY ACIDS DIRECTLY EXERT ANTI-INFLAMMATORY RESPONSES IN PODOCYTES AND TUBULAR EPITHELIAL CELLS EXPOSED TO HIGH GLUCOSE - Y. LI, J. Ma, Y. Loh, S. Chadban, H. Wu Kidney Int Reports
  Gut-microbiome derived short-chain fatty acids exert anti-inflammatory effects and delay progression of kidney disease in diabetic nephropathy. The aim of this study was to examine the impact in vivo and in vitro of short-chain fatty acid treatment on cellular pathways involved in the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0252 URINARY C-PEPTIDE CONTAINING FETUIN A PREDICTS PROGRESSIVE EGFR DECLINE IN TWO INDEPENDENT BI-ETHNIC COHORTS OF PATIENTS WITH TYPE 2 DIABETES - G.T. CHUANG, D. Kremer, C.H. Lin, C.H. Huang, T.L. Tseng, G. Laverman, S. Bakker, L.M. Chuang Kidney Int Reports
  There is a great clinical need for novel markers to predict kidney function decline and assess response to renoprotective treatment in patients with type 2 diabetes mellitus (T2DM), because current measures such as estimated glomerular filtration rate (eGFR) and albuminuria are insufficient. We (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0212 LIRAGLUTIDE IMPROVES BOTH DIABETIC NEPHROPATHY AND CARDIOMYOPATHY IN THE SDT FATTY RAT, A CARDIORENAL MODEL OF TYPE 2 DIABETES - F. BRIAND PhD, M. Shinohara, Y. Kageyama, T. Sulpice Kidney Int Reports
  The Glucagon-Like Peptide 1 (GLP-1) receptor agonist liraglutide (LIRA) has cardioprotective effects and may reduce the development of kidney disease in type 2 diabetic patients. We here evaluated the effects of LIRA on both kidney and heart function in the Spontaneously Diabetic Torii (SDT) (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0154 Cross-talk of Cilia Sensors and mTOR Signaling Pathway in Cystogenesis of Mouse Polycystic Kidney Disease Model - L. TRAN NGUYEN TRUC, S. Matsuda, T. Miyazaki, K. Yoshizawa, H. Tsukaguchi Kidney Int Reports
  Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disorder, caused by the defects of primary cilia and their signaling. A vast majority (93%) of the patients harbor a two-hit mutation in genes eitherPKD1(78%) orPKD2(15%). Two genes comprise a polycystin (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0135 IMG-025, EXHIBITS PROMISING POTENTIAL IN AMELIORATING IMMUNOGLOBULIN A NEPHROPATHY VIA INHIBITION OF LECTIN-MEDIATED COMPLEMENT ACTIVATION - P. Fan, R. Lei, Y. Wang, M. Zhang, C. Guo, L. Fan, J.J. Wang Kidney Int Reports
  Immunoglobulin A nephropathy (IgAN) is the most prevalent primary glomerulonephritis worldwide without disease-specific treatment. Its pathogenesis is complex and not completely clarified. Increasing evidence indicated that complement activation, especially lectin pathway-initiated complement (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0118 GROUP 3 INNATE LYMPHOID CELLS EXACERBATE LUPUS NEPHRITIS BY PROMOTING B CELL ACTIVATION IN KIDNEY ECTOPIC LYMPHOID STRUCTURES - F. LI, Z. Liang, H. Zhong, X. Hu, Z. Tang, C. Zhu, Y. Zhou Kidney Int Reports
  Innate lymphoid cells (ILCs) are a recently identified class of innate immune cells. The subset group 3 innate lymphoid cells (ILC3s), which are enriched in the intestinal mucosa, regulate immunity and promote lymphoid tissue development. Accumulating studies have suggested the pathogenic (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0099 SGLT2 INHIBITORS REDUCE URINARY MITOCHONDRIAL DNA COPY NUMBER IN BOTH DIABETIC AND NON-DIABETIC CKD PATIENTS - H. LEE, H. Kim, J.S. Jeon, H. Noh, S.H. Kwon Kidney Int Reports
  Sodium–glucose co-transporter 2 (SGLT2) inhibitors improve renal and cardiovascular outcomes in patients with chronic kidney disease (CKD) regardless of the presence of type 2 diabetes mellitus (T2DM). In this work, we aimed to investigate whether SGLT2 inhibitors improve mitochondrial (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0093 TLR9/TLR7 ARE STRONG CANDIDATES FOR DISEASE-SPECIFIC THERAPEUTIC TARGETS IN IgA NEPHROPATHY - M. LEE, H. Suzuki, R. Kato, Y. Fukao, M. Nakayama, T. Kano, Y. Makita, Y. Suzuki Kidney Int Reports
  IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. If left untreated, about 40% of patients progress to end-stage renal disease over 20 years. Currently, there is no established disease-specific treatment. Toll-like receptor (TLR)9 and TLR7 have been reported to be (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0065 CAUSAL AND PUTATIVE PATHOGENIC MUTATIONS WERE IDENTIFIED IN 38.6% OF CHILDREN WITH PRIMARY STEROID-RESISTANT NEPHROTIC SYNDROME IN SOUTH AFRICA - R. Bhimma Kidney Int Reports
  There is a paucity of data identifying genetic mutations that account for the high rate of steroid-resistant nephrotic syndrome (SRNS) in a South African paediatric population. (Kidney International Reports 8, 3 (2023))
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  WCN23-0056 PROTEOMIC PROFILE OF EDITED PODOCYTES BY CRISPR/CAS9 TECHNOLOGY EXPRESSING FABRY'S DISEASE PHENOTYPE - J. MONTE NETO, E. Pereira, A.S. Silva, H.M. Andrade, S.J.H. Monte, G.M. Kirsztajn Kidney Int Reports
  Nephropathy is one of the most severe manifestations of Fabry Disease (FD), a lysosomal storage disorder with X-linked pattern of inheritance caused by variants in the GLA gene, leading to insufficient alpha-galactosidase A (?-GAL) enzyme activity and progressive accumulation of (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0023 RENAL NECROTIC TISSUE INDUCES HYPERTENSION - R. LIU Kidney Int Reports
  The effect of renal necrotic tissue on blood pressure remains unclear. We hypothesized that infarcted renal tissue induces hypertension by stimulating inflammatory response. (Kidney International Reports 8, 3 (2023))
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  WCN23-1211 COST-EFFECTIVENESS ANALYSIS OF DAPAGLIFLOZIN FOR DIABETIC KIDNEY DISEASE IN MEXICO - M.G. NAVA-VARGAS, K.J. Arellano-Arteaga, L. Cortés-Sanabria, J. Andrade-Sierra, Ó.O. Márquez-Cabrera Kidney Int Reports
  Diabetic kidney disease (CKD), also known as diabetic nephropathy, is the leading cause of end-stage chronic kidney disease (ESKD) in the world, due to the increased prevalence of type 2 diabetes mellitus. CKD carries a health problem public health associated with high morbidity, mortality, (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1170 ASSOCIATION OF ANGIOTENSINOGEN GENE POLYMORPHISM WITH NEPHROPATHY IN TYPE 2 DIABETIC PATIENTS OF BANGLADESH - M. Iqbal, M.Z. Hassan, H.U. Rashid, A.N. Malik, M.S. Hassan, R. Morshed Kidney Int Reports
  Angiotensinogen (AGT) gene polymorphisms have been shown to be associated with hypertension and nephropathy especially in diabetics. In this study the polymorphism of angiotensinogen (AGT) gene at M235T and their association with nephropathy in Bangladeshi type 2 diabetes mellitus (T2DM) (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1143 DOES THE CHANGING EPIDEMIOLOGY AND THE THERAPEUTICS HAVE INFLUENCE ON THE SPECTRUM OF RENAL DISEASES IN PATIENTS WITH DIABETES MELLITUS? - V. VEERANKI, N. Prasad, J. Meyyappan, D. Bhadauria, A. Kaul, M. Patel, R.S. Kushwaha, M. Behera, M. Yachha Kidney Int Reports
  The renal involvement in diabetes could be either due to Diabetes Mellitus (Diabetic kidney disease, DKD), non-diabetic kidney disease (NDKD) or both. Despite an increasing prevalence of Type-2 DM, the overall prevalence of DKD is relatively stable. Besides the increased use of RAAS blockers, (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1069 ROLE OF GASTROINTESTINAL DIALYSIS IN RESOURCE-LIMITED SETTING: IMPACT OF ACTIVATED CHARCOAL & LACTULOSE ON BIOCHEMICAL PARAMETERS AND OUTCOME IN PATIENTS UNDERGOING INFREQUENT DIALYSIS IN NIGERIA - S. Sharma, T. SOTUBO, A. Olugbenga Jacob Kidney Int Reports
  Chronic kidney disease (CKD) is a non-communicable disease with an increasing prevalence globally. The number of patients requiring renal replacement therapy due to End-stage renal disease (ESRD) is also on the rise. Haemodialysis is the most frequently modality of treatment for patients with (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1052 The prevalence of hyperuricemia and its effect on the prognosis in chronic kidney disease with type 2 DM: a multicenter, retrospective, real-world cohort study - S. ZHANG, S. zhang, J. xie, Q. li, Y. zhang, H. tao, W. wang Kidney Int Reports
  To explore the prevalence of hyperuricemia and its effect on the prognosis in chronic kidney disease?CKD?with type 2 diabetes mellitus (DM) in the real world. (Kidney International Reports 8, 3 (2023))
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  WCN23-1037 IMPLEMENTATION OF SUPPLEMENTED VERY LOW PROTEIN DIET (SVLPD) IN TYPE 2 DIABETIC KIDNEY DISEASE (DKD) PATIENTS IN SINGAPORE. INSIGHTS FROM A PILOT RANDOMISED CONTROLLED STUDY - S.T. CHONG, S. Teoh, A.Y.L. Liu Kidney Int Reports
  A supplemented very low protein diet (sVLPD) with ketoanalogues (KAs), together with other important dietary interventions, was shown to retard chronic kidney disease (CKD) progression in non-DKD (1). To date, there are no studies have yet been designed to evaluate the effect of sVLPD in (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1030 EFFECTS OF ATRASENTAN ON MARKERS OF LIVER FUNCTION IN PATIENTS WITH TYPE 2 DIABETES AND CHRONIC KIDNEY DISEASE - H. Lambers Heerspink, A. Liew, S.C.W. Tang, J. Barratt, D. Kohan Kidney Int Reports
  The selective endothelin receptor A antagonist (ERA) atrasentan reduced the risk of kidney failure in patients with type 2 diabetes and chronic kidney disease (CKD). Rare, but serious drug induced liver injury (DILI) has been previously reported with some ERAs, possibly due to chemical (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1006 IRISIN AMELIORATES DIABETIC KIDNEY DISEASE BY RESTORING AUTOPHAGY IN PODOCYTES - W. LAI, H. Peng Kidney Int Reports
  Many studies have highlighted the importance of moderate exercise. While it can attenuate diabetic kidney disease, its mechanism has remained unclear. The level of myokine irisin in plasma increases during exercise. (Kidney International Reports 8, 3 (2023))
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  WCN23-0991 DAPAGLIFLOZIN IMPROVES PODOCYTES INJURY IN DIABETIC NEPHROPATHY VIA REGULATING CHOLESTEROL BALANCE THROUGH KLF5 TARGETING ABCA1 SIGNALING PATHWAY - Q. Wang, X. Zhang, S. Wang, D. Chen, N. Chong, J. Shu, R. Wang, Y. XU Kidney Int Reports
  Diabetic nephropathy (DN), one of the most common microvascular complications in patients with diabetes mellitus, accounts for the main cause of end stage renal disease (ESRD). Lipotoxicity in podocytes caused by hyperglycemia has already been recognized as the crucial pathology changes which (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0975 NEGATIVE REGULATION OF METTL3/WISP1 AXIS ALLEVIATES DIABETIC NEPHROPATHY BY INHIBITING CELL PROLIFERATION, MIGRATION, EMT AND FIBROSIS - D. SONG Kidney Int Reports
  Diabetic nephropathy (DN) is one of the most serious complications in diabetic patients. The progressive development of DN is frequently accompanied by podocyte apoptosis, and epithelial mesenchymal transition (EMT) of renal tubular cells, as well as renal fibrosis, etc. METTL3-mediated m6A (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0953 FAILURE OF SGLT-2 INHIBITOR IN THE CONTEXT OF NEW ILEAL CONDUIT FORMATION - J. ALMOG, S. Jain, P. Pybass, A. Gupta Kidney Int Reports
  CASE REPORT (Kidney International Reports 8, 3 (2023))
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  WCN23-0949 PGC1? MODULATES MITOCHONDRIAL HOMEOSTASIS IN TUBULAR CELLS OF DIABETIC KIDNEY DISEASE - S. YE, B. Li, Y. Fan, Y. Lin, S. Li, H. Peng, H. Diao, W. Chen Kidney Int Reports
  Tubular injury and dysregulated mitochondrial dynamics play pivotal roles in the pathogenesis of diabetic kidney disease (DKD). However, the potential mechanism by which mitochondrial dysfunction-initiated tubulopathy triggers intrarenal signaling and mediates DKD progression remains elusive. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0916 GROWTH ASSOCIATION PROTEIN 43 DEFICIENCY PROMOTES PODOCYTE INJURY BY ACTIVATING THE CALMODULIN/CALCINERUIN PATHWAY UNDER HYPERGLYCEMIA - Y. YAN, Z. Li, X. Liang Kidney Int Reports
  Diabetic kidney disease (DKD) is the leading cause of chronic and end-stage renal disease worldwide. Compelling evidence identifying injury and loss of podocytes as the key mediator in the pathogenesis of DKD. Studies have demonstrated calmodulin (CaM)/calcineurin (CaN) pathway plays a key role (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0899 Novel insights: differentially expressed tsRNAs modulate the advance of early stage Diabetic Nephropathy in mice - H. Zhu, L. Luo, N. Liu Kidney Int Reports
  Diabetic nephropathy is a major cause of end-stage renal disease, and the recently popular tubulocentric theory suggests that early tubular injury may be the initiating factor of diabetic nephropathy injury. tsRNA, a novel non-coding RNA, has recently been considered as a biomarker for various (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0842 METTL3-MEDIATED M6A MODIFICATION OF SIGMAR1 mRNA PROMOTES PODOCYTE GLYCOLYSIS IN DIABETIC NEPHROPATHY - L. Jiang, Y. Wu Kidney Int Reports
  Diabetic nephropathy (DN) has become one of the main causes of end-stage renal disease. It is characterized by microalbuminuria to macroalbuminuria and renal insufficiency. Therefore, how to reduce or prevent the occurrence of proteinuria has very important practical significance. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0821 TRANSMEMBRANE PROTEIN 72, EXPRESSED IN THE DISTAL CONVOLUTED TUBULE, MAY PLAY A POTENTIAL ROLE IN DIABETIC KIDNEY DISEASE - J. XIE, M. Lu, Q. Li, D. Liu, S. Li, Y. Zhang, S. Zhang, X. Chen, H.H. Yau, S. Lin, W. He, H. Tao, W. Wang Kidney Int Reports
  Transmembrane protein 72 (TMEM72) is highly expressed in tubules of the kidney. This study is designed to explore the role and the potential mechanism of TMEM72 in the development of diabetic tubulopathy. (Kidney International Reports 8, 3 (2023))
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  WCN23-0816 EXPLORATION OF NOVEL EXOSOME-TARGETED STRATEGY FOR DIABETIC KIDNEY DISEASE BY DRUG SCREENING TO INHIBIT INTRAGLOMERULAR CROSS-COMMUNICATION - D. FUJIMOTO, S. Umemoto, T. Kuwabara, R. Date, M. Mukoyama Kidney Int Reports
  Extracellular vesicles (EVs) are important mediators of intercellular communication in the regulation of physiological and pathophysiological processes. Particularly, exosome-mediated intercellular crosstalk has been addressed in several disorders such as cancer and lifestyle-related diseases. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0814 CIRC-0000953 DEFICIENCY EXACERBATES PODOCYTE INJURY AND AUTOPHAGE THROUGH TARGETING MIR-655/ATG4B IN DIABETIC NEPHROPATHY - X. Liu, Y. Wu Kidney Int Reports
  circRNAs are a new class of endogenous non-coding RNA with a closed ring structure. circRNA acts by "sponge" absorbing miRNA. N6-methyl-adenosine (m6A) is an important RNA modification in eukaryotes, regulating circRNA activity and biological function. In the previous stage, our team conducted (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0810 THE EFFECTS OF SGLT2 INHIBITORS ON RENAL FUNCTION AND SERUM SODIUM CONCENTRATION TRENDES IN PATIENTS WITH TYPE 2 DIABETES - T. Kuwabara, T. Mizumoto, Y. Kakizoe, Y. Izumi, M. Adachi, M. Mukoyama Kidney Int Reports
  The renoprotective effects of SGLT2 inhibitors (SGLT2i), particularly in patients with type 2 diabetes mellitus, has become a worldwide consensus treatment, with multiple mechanisms proposed. In this single-center, retrospective cohort study, we investigated the effects on renal function and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0790 Ubiquitination in the Proteome in Mouse Model of Diabetic Nephropathy - L. LIANG, M. He, S. Pan, S. Zhou, D. Liu, Z. Liu Kidney Int Reports
  Diabetic nephropathy, a major microvascular complication of diabetes, is characterized by its complex pathogenesis, higher risk of chronic renal failure, and the lack of effective diagnosis and treatment methods. Ubiquitination is a process of ubiquitin modification of specific target proteins. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0761 SGLT2 INHIBITOR TREATMENT MAY ENHANCE KIDNEY OXYGENATION AND ATTENUATE HIF1A EXPRESSION IN YOUNG PERSONS WITH TYPE 2 DIABETES - V. Nair MS, J. Schaub, F. Alakwaa, P. McCown, A. Naik, P. Ladd, R. Harned, H. Looker, P. Pottumarthi, L. Luping, L. Pyle, F.C. Brosius, R. Nelson, M. Kretzler, P. Bjornstad Kidney Int Reports
  Clinical trials have demonstrated the salutary effects of SGLT2 inhibitors (SGLT2i) on kidney and cardiovascular disease in type 2 diabetes (T2D), but the mechanisms of their effects are unclear. We examined the effect of SGLT2i on kidney oxygen availability and single cell transcriptional (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0734 A NOVEL AND UNIQUE FC-FUSION PROTEIN I-BODY AD-214 AMELIORATES KIDNEY FIBROSIS THROUGH INHIBITION OF LEUKOCYTE INFILTRATION - Q. Cao PhD, M. Foley, A. Gill, A. Chou, C. Xin-Ming, P. Carol Kidney Int Reports
  Tissue fibrosis is the common pathological pathway in progressive chronic kidney disease (CKD). Current clinical practices are ineffective in limiting renal fibrosis. CXCR4 has been demonstrated to be central to the development of fibrosis. The usage of neural cell adhesion molecules as (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0618 CARDIORENAL OUTCOMES WITH FINERENONE IN ASIAN PATIENTS WITH CHRONIC KIDNEY DISEASE AND TYPE 2 DIABETES: PRESPECIFIED SUB-ANALYSIS FROM FIDELITY - D. Koya, L.M. Ruilope, P. Rossing, Z.H. Liu, B.W. Lee, C.T. Lee, S.D. Anker, M. Gebel, R. Lawatscheck, M. Seco, B. Pitt Kidney Int Reports
  In FIDELITY, the pooled analysis of phase III trials FIDELIO-DKD (NCT02540993) and FIGARO-DKD (NCT02545049), finerenone significantly improved cardiorenal outcomes in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D). A prespecified sub-analysis of FIDELITY data was conducted (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0536 RENAL FUNCTION DECLINE IN TYPE 2 DIABETIC PATIENTS WITH NORMAL TO MODERATELY INCREASED ALBUMINURIA: A 15-YEAR FOLLOW-UP STUDY - K. JINTANAPRAMOTE, P. Katavetin Kidney Int Reports
  The classical concept of diabetic kidney disease believes that the significant deterioration of kidney function occurs exclusively in diabetes patients with severely increased albuminuria. This concept has been challenged by the increasing number of reports demonstrating kidney failure in (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0528 RENO-PROTECTIVE EFFECT OF LIRAGLUTIDE IN T1DM: A NOVEL ANTI-INFLAMMATORY THEORY - N. YOUSSEF, M. Noureldein, G. Sfeir, A. Eid Kidney Int Reports
  Diabetic kidney disease (DKD) is one of the most deleterious complications associated with diabetes. Macrophages have been described to be involved in the initiation as well as the progression of the immune response in DKD. However, the pathophysiological intracellular mechanisms of macrophage (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0521 EMPAGLIFLOZIN VERSUS DAPAGLIFLOZIN IN PATIENTS WITH TYPE 2 DIABETES ADEQUATELY CONTROLLED DIABETES AND PROTEINURIA: A ONE YEAR RETROSPECTIVE OBSERVATIONAL STUDY - A.I. Akl, A.T. Almaghrabi, E.A. Alzahrani, G.N. Qorban, R.T. Ismail, S.A. Binsalman, A.H. Algrigri, A.A.A. Alhusaini, F. Aldhaheri, D. Waqas Kidney Int Reports
  Sodium-glucose co-transporter 2 (SGLT2) inhibitors may decrease risk of renal function deterioration and proteinuria progression but, there are little clinical data about the comparison between dapagliflozin (DAPA) versus empagliflozin (EMPA) in patients with diabetes mellitus (DM) over one (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0472 UNDERSTANDING THE MECHANISM OF SGLT2 INHIBITOR IN YOUNG PERSONS WITH TYPE 2 DIABETES USING SINGLE-CELL RNA-SEQ DATA - F. ALAKWAA, J. Schaub, P. McCown, A. Naik, S. Eddy, V. Nair, L. Pyle, J. Hodgin, F. Brosius, R. Nelson, M. Kretzler, P. Bjornstad Kidney Int Reports
  Youth-onset type 2 diabetes (T2D) carries a higher risk of diabetic kidney disease (DKD) than type 1 and adult-onset type 2 diabetes of similar duration, with few treatment options. SGLT2 inhibitors (SGLT2i) are protective against DKD, but the mechanisms of nephroprotection are incompletely (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0471 THE ENHANCEMENT OF METALLOTHIONEIN BIND METAL PATHWAY WITH SGLT2 INHIBITORS IN KIDNEY PROXIMAL TUBULES OF ADOLESCENTS WITH TYPE 2 DIABETES USING SINGLE CELL RNA-SEQ DATA - F. ALAKWAA, P. McCown, A. Naik, J. Schaub, R. Menon, E. Otto, V. Nair, S. Eddy, L. Pyle, J. Hartman, J. Hodgin, R. Nelson, F. Brosius Division, M. Kretzler, P. Bjornstad Kidney Int Reports
  Oxidative stress is the main contributor to diabetic kidney disease (DKD), and SGLT2 inhibitors (SGLT2i) mitigate DKD onset in type 2 diabetes (T2D). An investigation of cell-type specific molecular reprogramming in the kidney with SGLT2i treatment was undertaken in young persons with (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0465 SIX MONTHS OUTCOME OF EMPAGLIFLOZIN IN DIABETIC KIDNEY DISEASE PATIENTS IN BANGLADESH - S. Kar, D. Das Gupta Kidney Int Reports
  Empagliflozin is a useful drug to combat diabetic kidney disease.There are not enough data on Bangladeshi patients regarding its usefulness.So we studied it on Bangladeshi patients. (Kidney International Reports 8, 3 (2023))
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  WCN23-0462 DIABETIC KIDNEY DISEASE: A COMPARISON OF SELECTED COHORTS OF PATIENTS FROM LOW-MIDDLE AND HIGH INCOME COUNTRIES - M. Mattiotti, I. Capelli, D. Ribichini, D. Vetrano, V. Vicennati, G. Cianciolo, V. Aiello, M. Righini, N. Bazzanini, K. Mutalemwa, I. Rehema, E. Ndile, U. Pagotto, G. Azzimonti, G. La Manna Kidney Int Reports
  Diabetic kidney disease (DKD) still represents the leading cause of kidney failure worldwide. If compared to other diabetes complications, its prevalence has failed to decline over past decades. The classical paradigma of albuminuric DKD has been replaced by a wider spectrum of (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0428 RENAL AUTOLOGOUS CELL THERAPY (REACT™) FOR DIABETIC CHRONIC KIDNEY DIEASE: PHASE II TRIAL WITH BILATERAL CORTEX INJECTIONS AND RE-DOSING TRIGGERS - J. Stavas, A. Silva, A. Aqeel, T. Wooldridge, M. Yanover, R. Prakash, N. Mirkovic, L. McKenzie Kidney Int Reports
  Cell-based therapies may repair diseased nephrons and stabilize and enhance kidney function to delay the onset of end-stage kidney disease and improve co-morbidities. REACT™ is a novel product formed of cryopreserved autologous homologous selected renal cells, undergoing phase III clinical (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0424 THE proact PHASE 3 STUDY DESIGN: A RANDOMIZED CONTROLLED STUDY OF REACT IN PARTICIPANTS WITH TYPE 2 DIABETES AND CHRONIC KIDNEY DISEASE - K. Cooper, H. Lambers Heerspink, A. Liew, J. Stavas, L. McKenzie, T. Bertram, A. Johns, R. Pecoits-Filho, K.R. Tuttle Kidney Int Reports
  The global burden of chronic kidney disease (CKD) is estimated at 850 million people worldwide, with diabetic kidney disease (DKD) being the main cause. Existing medical therapies may delay the deterioration of kidney function; however, many patients continue to progress to kidney failure. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0380 NEUTROPHIL EXTRACELLULAR TRAPS AND INFLAMMATORY RESPONSE IN DIABETIC KIDNEY DISEASE – INTEGRATING DATA FROM BULK RNA SEQUENCING and SINGLE-NUCLEUS RNA SEQUENCING ANALYSES - R. XIE, L. Zhu, K.H.J. Sher, D.Y.H. Yap Kidney Int Reports
  Neutrophil extracellular traps (NETs) represent a key defence mechanism against infections and shows pathogenic relevance in different autoimmune disorders. Mounting data suggests the role of inflammation in diabetic kidney disease (DKD), but the contributions of NETs in disease pathogenesis (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0205 Cyclosporin A-induced activation of the renal NaCl cotransporter depends on the presence of Kir4.1 in the distal convoluted tubule - P. Wu, Z.X. GAO, R. Zhou, M.Y. Li, S.T. Li, Z.H. Mao, T.T. Shu, D.W. Liu, Z.S. Liu Kidney Int Reports
  Cyclosporin A (CsA) is a widely used immunosuppressive drug that causes hypertension and hyperkalemia. Moreover, CsA-induced stimulation of the thiazide-sensitive NaCl cotransporter (NCC) in the kidney has been shown to be responsible for the development of hyperkalemic hypertension. In this (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1168 Nogo-B suppresses endoplasmic reticulum stress in glomerular endothelial cells of diabetic nephropathy - Z. YAN, J.Y. Lan, S. Yang, P.M. Liu, H.S. Xu, H. Jiang, X. Bai Kidney Int Reports
  Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes mellitus. Diabetic vascular injuries contribute to the disease progression and glomerular endothelial cells are the critical targets of injury under hyperglycemia. Previous studies have shown that the damage (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1114 APOE-MEDIATED LIPID ACCUMULATION IN ENDOTHELIUM - A PILOT INVESTIGATION OF A COMMON PATHOLOGY IN CHRONIC KIDNEY DISEASE AND AGE-RELATED DEMENTIA - H.Y.M. YEUNG, G.W.Y. Cheng, K.H. Tse Kidney Int Reports
  Hyperlipidemia is one of the most prevalent risk factors for chronic kidney disease (CKD). It is mostly caused by excessive lipid intake or abnormal metabolism leading to either hypercholesterolemia, hypertriglyceridemia or both. The excessive lipids stored in various renal cells including (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0832 LCN2 promotes vascular calcification via activating VSMCs ferroptosis through NOCA4/FTH1 ferritinophagy pathway in CKD - Y. Wang, Y. Zhang, R. Tang, L. bicheng, T. taotao Kidney Int Reports
  Vascular calcification (VC) is prevalent in patients with chronic kidney disease (CKD) and a major risk factor of cardiovascular disease?but the mechanism of VC remains elusive and there is a lack of pharmacologic treatment. Accumulating studies have demonstrated that derangements in iron (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0146 CHOLECALCIFEROL SUPPLEMENTATION IN CHRONIC KIDNEY DISEASE: EFFECT ON IMMUNE AND VASCULAR FUNCTION - K. Kamboj, A. Pariki, M. Singhal, S. Naik, H.S. Kohli, V. Kumar, A.K. Yadav, V. Jha Kidney Int Reports
  Vitamin D deficiency is common in chronic kidney disease (CKD) and short term studies have shown beneficial effect of vitamin D supplementation on vascular function in CKD. In this study we investigated the effect of cholecalciferol supplementation on vascular and immune functions in (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1169 THE NGAL PROMOTES PROTEINURIA AND FAVORS THE PROGRESSION OF RENAL FIBROSIS GENERATED BY THE URETERAL OBSTRUCTION IN MICE - S. FIGUEROA, P. Araos, J. Reyes, E. Guzmán, M.J. Fuenzalida, C. Lucero, R. Pacheco, C.A. Amador Kidney Int Reports
  Chronic kidney disease (CKD) is characterized by a loss of renal function associated with inflammatory and fibrotic processes, which can progress with high levels of proteinuria. The increase of proteinuria is a recognized risk factor in patients, and experimental studies suggest that it is (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1158 A TRANSLATIONAL APPROACH TO IDENTIFY NON-INVASIVE SURROGATES AS PREDICTORS OF RESPONSE TO mFT011 IN KIDNEY DISEASE - S. Eddy PhD, A. Kompa, J. Hartman, F. Eichinger, B. Godfrey, E. Tanner, W. Ju, A. Edgely, R. Langham, L. Mariani, M. Kretzler, D. Kelly Kidney Int Reports
  Interstitial fibrosis is a common endpoint of injury in most kidney diseases and one of the strongest predictors of kidney disease progression. A novel agent mFT011 demonstrated anti-fibrotic efficacy in preclinical models and has an excellent safety profile in Phase I and II studies. A (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1154 TRIAL IN PROGRESS: AN OPEN-LABEL, PHASE 2 STUDY TO EVALUATE EFFICACY, SAFETY, PK, PD OF KP104, A BIFUNCTIONAL COMPLEMENT INHIBITOR, IN IGAN AND C3G SUBJECTS - J. Lv, H. Zhang, E. Pedagogos, J. Ma, H. Zhou, M. Rabe, A. Hart, C. Yue, A. Yan, P. Tsui, J. Wu, H. Fu, R. Lee, C. Wang Kidney Int Reports
  Uncontrolled or inappropriate complement activation causes inflammation, and the complement system has been implicated in the pathogenesis of a wide range of kidney diseases including IgA nephropathy (IgAN), C3 glomerulopathy (C3G), Lupus nephritis, aHUS, ANCA-associated vasculitis, and MPGN (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1112 EVALUATION OF NOVEL BIOMARKERS FOR IGA NEPHROPATHY IN THE BULGARIAN POPULATION - I. Kostadinova, M. Lyubomirova, B. Bogov, D. Kyurkchiev, G. Vasilev Kidney Int Reports
  IgA nephropathy remains one of, if not the, most common forms of glomerulonephritis, especially in developed countries. A potential noninvasive approach for early diagnosis of the disease is the use of reliable biomarkers. Serum levels of galactose-deficient IgA1 (Gd-IgA1) and glycan-specific (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1068 THE ROLE AND MECHANISM OF PGC-1B IN THE PROGRESSION FROM ACUTE KIDNEY INJURY TO CHRONIC KIDNEY DISEASE - D. WANG, J. Fan, X. Wang, J. Li, W. Chen Kidney Int Reports
  Acute kidney injury(AKI) has become an independent risk factor for chronic kidney disease(CKD). Therefore, exploring and elucidating the mechanism of the progression of AKI to CKD (AKI-CKD) is essential for preventing and treating the development of AKI to CKD. However, its pathogenic mechanism (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1048 PI3K-Akt-mTOR PATHWAY REGULATES PERICYTE-MYOFIBROBLAST TRANSITION THROUGH REGULATING HKII - L. CHEN, L. Xiaofan, B. Xueyuan, C. Xiangmei Kidney Int Reports
  An increasing number of comprehensive genetic fate mapping studies have demonstrated that pericytes are the main progenitors of renal scar-forming myofibroblasts, and contribute in poor repair in acute kidney injury and progression to chronic kidney disease. Following unilateral ureteral (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1034 miR-1224 of circulating extracellular vesicles induce mitochondria-mediated podocyte injury by inhibiting CREB/PGC-1? pathway in metabolic syndrome - X.Q. LI, H.H. Liu, K. Ma, Z.R. Zheng, J.F. Liu, H. Liu, Y. Meng Kidney Int Reports
  Metabolic syndrome (MetS) is a cluster of abnormalities related to metabolism that increase the risk for kidney diseases. Circulating miRNAs contained in extracellular vesicles (EVs) act as endocrine factors and mediate metabolic organ crosstalk, but their roles in kidney injury during MetS (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1033 NOVEL ASPECT OF NATURAL FLAVONOL FISETIN VIA INHIBITING ACSL4-MEDIATED TUBULAR FERROPTOSIS AGAINST FIBROTIC KIDNEY DISEASE - L. YANG, B. Wang, L. Ma, P. Fu Kidney Int Reports
  Fibrosis is the final common pathway of CKD,but now,no efficient, and broadly applicable anti-fibrotic therapies exist. As we reported before, the natural product fisetin could improve kidney fibrosis of hyperuricemic nephropathy. However, its potential mechanism of it against fibrotic kidney (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1029 Changes of URAT-1 in unilateral ureter obstruction model - S.K. KWON, N.G. Park, H.Y. Kim Kidney Int Reports
  Gout is a form of inflammatory arthritis that results from an excess of uric acid in the blood and deposition of monosodium urate crysta. Hyperuricemia is an important risk of gouty arthritis, but it is not well correlated between severity of gout and serum uric acid level. Chronic (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1024 Elevated Human IgA1 Expression and O-glycosylation Change with Increased Pathogen Exposure on IGHA1 Knock-in Mouse Model - R. LI, M. Wang, X. Xie, W. Tian, Y. Zhang, J. Li, Y. Dong, J. Zan, J. Jin, M. Zhao, J. Lv, H. Zhang Kidney Int Reports
  IgA nephropathy is characterized by IgA deposition in the mesangial areas of glomerulus with elevated serum IgA1 and galactose-deficient IgA1 (Gd-IgA1). In the present study, we constructed immunoglobulin heavy constant alpha 1 knock-in (IGHA1+/+) mice and investigated the effects of different (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1004 Urine-Derived Stem Cell attenuated renal fibrosis via Klotho activation - D.E. Choi, Y. Hwang, H. Park, S. Han, J.A. Shin, H. Park, J.Y. Jeong, K.R. Na, K.W. Lee, Y.K. Chang Kidney Int Reports
  After renal IRI, regeneration and recovery of the renal tubular cell occurs. However, if the renal repair process is maladaptive, it progresses to renal fibrosis. The role of stem cells in kidney regeneration or fibrosis has not been fully elucidated. we evaluated the urine derived stem (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1003 Deletion of PTP4A1 ameliorate renal fibrosis induced by UUO in mice - D.E. Choi, H. Park, Y. Hwang, J.A. Shin, H. Park, S. Han, Y.R. Ham, K.R. Na, K.W. Lee, Y.K. Chang Kidney Int Reports
  Inhibitors of protein tyrosine kinases(PTP) has been investigated as potential anti-fibrotic agents. PTP4A1 belongs to a sub-class of three prenylated PTP. PTP4A1 has known as promoting growth and migration of tumor cells. The role PTP4A1 has little known in kidney. We evaluated whether the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0999 IDENTIFICATION OF DIFFERENTIALLY EXPRESSED PROTEINS IN SERUM OF RENAL AMYLOIDOSIS PATIENTS - N. Gupta, S. Wajid, D. Khullar Kidney Int Reports
  Amyloidosis is a group of disorders characterized by the deposition of misfolded fibrillar proteins in the extracellular matrix of various organs, including the kidneys, heart and gastrointestinal tract. Thus far, 36 structurally unrelated proteins have been identified to cause amyloidosis. The (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0957 FAB FRAGMENT IS THE POTENTIAL BINDING SITE FOR GALACTOSE-DEFICIENT IGA1 DEPOSITION IN MESANGIUM IN PATIENTS WITH IGA NEPHROPATHY - M. SI, J. Fu, H. Hu, X. Yu Kidney Int Reports
  IgA nephropathy (IgAN) is the most common glomerulonephritis, characterized by the presence of predominant IgA deposits in the mesangium. The deposition of galactose-deficient IgA1(Gd-IgA1) in the mesangium is an essential initiating process, but its mechanism has not been fully (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0945 SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR, DAPAGLIFLOZIN, AMELIORATES HIGH GLUCOSE INDUCED EMT VIA UPREGULATING ANGIOTENSIN CONVERTING ENZYME 2 IN HK2 CELLS. - S. Wang, X. Zhang, N. Chong, D. Chen, J. Shu, R. Wang, Q. Wang, Y. XU Kidney Int Reports
  Dapagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, has been widely used in treatment of diabetic nephropathy (DN). Previous studies have shown that it has both glucose-lowering effects and renoprotective functions in DN. Tubulointerstitial fibrosis plays an important role in the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0931 A DITERPENE FROM BUDS OF WIKSTROEMIA CHAMAEDAPHNE SUPPRESSES RENAL FIBROSIS VIA BLOCKADE OF WNT/?-CATENIN SIGNALING - X. HU, Z. Tang, R. Lin, J. Yu, W. Chen, S. Yin, Y. Zhou Kidney Int Reports
  Cumulating evidence indicates that chronic kidney disease (CKD) becomes one of the greatest threats to the public health, affecting 10% of the general population globally. Renal fibrosis is the hallmark and common pathological feature of CKD. However, no treatment targeting renal fibrosis is (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0920 THERAPEUTIC STRATEGIES TARGETING RAGE IMPROVES RENAL OUTCOME IN LUPUS NEPHRITIS - K. TAGUCHI, K. Mori, M. Akito, K. Fukami Kidney Int Reports
  Lupus nephritis (LN) occurs in up to 60% of patients with systemic lupus erythematosus (SLE). Despite of current development of immunosuppressant agents, LN still impairs the survival and quality of life in SLE patients. Receptor for advanced glycation endproducts (RAGE) is a multi-ligand (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0913 Outcomes of BTD vs BCD as initial treatment of renal AL amyloidosis: a real-world retrospective study in a Chinese single center - L. SHENG, Y. Hok-him, X. Jianteng, L. Qiuling, Z. Yifan, L. Shaochun, L. Pengjun, T. Zekun, L. Qiongwen, F. Hongwen, L. Hui, L. Liwen, Z. Liye, T. Han, W. Wenjian Kidney Int Reports
  To explore the efficacy and safety of BTD therapy (bortezomib with thalidomide and dexamethasone) as the initial treatment for renal AL amyloidosis. (Kidney International Reports 8, 3 (2023))
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  WCN23-0908 Significant correlation of antibody repertoire perturbations to clinical manifestations in lupus nephritis - H. ZENG Kidney Int Reports
  Lupus nephritis (LN), characterized by immune complex formation through autoantibodies recognizing multiple autoantigens and kidney deposition, is a major cause of morbidity and mortality that affects up to 60% of the SLE population during disease. As aberrant B cells play pivotal roles in LN, (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0905 SYSTEMATIC MICROBIOME DYSBIOSIS ARE ASSOCIATED WITH IGA NEPHROPATHY - F. CAI, C. Zhou, N. Jiao Kidney Int Reports
  There are studies show that immunoglobulin A nephropathy (IgAN) is significantly associated with oral, tonsil and gut flora. However, these studies are either with small sample size, or in a single body site, or both. Our study aimed to understand the associations of microbiome across multiple (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0885 EVAULATION OF CROCKCROFT-GAULT TO CALCULATE GFR - H. Vattappilly Siddique, M. Munir, P. Ande, S. Rayadurgam, M. Richardson Kidney Int Reports
  Objective: This study aimed to evaluate if Crockcroft-Gault (CG) a reliable way to calculate gfr to decide on drug dosing. (Kidney International Reports 8, 3 (2023))
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  WCN23-0852 MOLECULAR IMAGING OF PDGFR-? IN KIDNEY FIBROSIS - B.M. KLINKHAMMER, D. Moeckel, M. Wagner, F. Kiessling, T. Lammers, P. Boor Kidney Int Reports
  Chronic kidney disease affects >10% of the world's population and is associated with high mortality and morbidity. The best predictor of CKD progression is the extent of fibrosis, i.e., pathological deposition of extracellular matrix and loss of functional kidney parenchyme. Currently, there (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0851 URINARY C-PEPTIDE CONTAINING FETUIN A (uC-FetA) PREDICTS LOSS OF KIDNEY FUNCTION IN KIDNEY TRANSPLANT RECIPIENTS - D. KREMER, F.F. Alkaff, C.A. te Velde-Keyzer, J. van den Born, S.P. Berger, G.D. Laverman, T.L. Tseng, S.J.L. Bakker Kidney Int Reports
  Urinary C-peptide containing Fetuin A (uC-FetA) has been identified as a biomarker for kidney function decline in patients with diabetic kidney disease and acute kidney injury, and is proposed as a biomarker for early detection of kidney function deterioration. We studied whether uC-FetA may (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0823 A CLUSTER OF TYPE I NTERFERON-REGULATED GENES ASSOCIATES WITH PATHOLOGICAL SEVERITY AND PROGNOSIS IN PATIENTS WITH IgAN - S. QU, T. Gan, Y. Wang, Y. Qi, Y. Zhang, L. Liu, S. Shi, J. Lv, X. Zhou, H. Zhang Kidney Int Reports
  Upregulation of interferon-regulated genes (IRGs), denoted IFN signature, in peripheral blood has been used as an indirect measure of IFN pathway activation in patients with many autoimmune and inflammatory diseases. More recent genome-wide association study (GWAS) meta-analysis has detected (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0794 KIDNEY FAILURE RISK EQUATIONS: EXTERNAL ASSESS PERFORMANCE IN A MULTICENTER CKD RESEARCH COHORT - M. HUI, J. Ma, H.Y. Yang, Y.M. Zhang, J.W. Wang, F. Wang, B.X. Gao, M.H. Zhao, J.C. Lv, L. Yang, L.X. Zhang, X.Z. Zheng Kidney Int Reports
  Identifying patients at risk of chronic kidney disease (CKD) progression may facilitate decision-making between patients and nephrologists. The kidney failure risk equations (KFREs) were proposed and have been externally validated in multiple regions, but lack the support of data in China since (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0771 Identification of Key Biomarkers and Immune Cell Infiltration in IgA Nephropathy by Peripheral Blood Transcriptome Analysis - T. GAN, Y. Wang, Y. Qi, Y. Zhang, L. Liu, S. Shi, J. Lv, X. Zhou, H. Zhang Kidney Int Reports
  IgA nephropathy (IgAN) is the most common primary glomerulonephritis globally and its exact pathogenesis remains unclear. With significant developments in emerging technologies, large amount of data is increasingly available. Transcriptome profiling, as immediate readout of our genome, is an (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0766 THE ROLE OF IGA+ PLASMA CELLS INFILTRATING IN THE KIDNEYS OF IGA NEPHROPATHY MODEL MICE AND PATIENTS - Y. NIHEI, H. Iwasaki, Y. Fukao, M. Nakayama, H. Suzuki, Y. Suzuki Kidney Int Reports
  In IgA nephropathy (IgAN), nephritogenic IgA are thought to be produced by plasma cells (PCs) in the bone marrow and/or mucosal lumen, whereas PCs are often found in the inflamed kidneys in autoimmune diseases like systemic lupus erythematosus. We previously found that IgA+ PCs infiltrated in (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0749 THE ROLE OF WNT/?-CATENIN/PRR SIGNAL IN HYPERTENSIVE RENAL FIBORSIS - L. XIAO Kidney Int Reports
  Hypertension is a major independent risk factor for chronic kidney diseases. However, the exact pathologic mechanisms of hypertensive renal fibrosis are still unknown. Our preliminary studies demonstrated that dysregulated activation of the key developmental signaling pathway Wnt/?-catenin (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0693 METADHERIN PROMOTES PODOCYTE INJURY AND PROTEINURIA THROUGH ACTIVATING cAMP/PKA/?-CATENIN SIGNALING - X. CHEN, J. Xiao, D. Tao, Y. Liang, S. Chen, L. Shen, S. Li, Z. Zheng, Y. Zeng, C. Luo, F. Peng, H. Long Kidney Int Reports
  Podocyte damage is the major cause of glomerular injury and proteinuria in multiple chronic kidney diseases (CKD). Metadherin (MTDH), acts as a prominent oncogene in multiple tumors, but also contributes to renal tubular injury in mouse models of diabetic nephropathy and renal fibrosis. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0685 SINGLE-ARM, PHASE 1B, OPEN-LABEL STUDY ASSESSING THE SAFETY, TOLERABILITY, AND PHARMACODYNAMICS OF REPEAT-DOSE SUBCUTANEOUS ANX009 PLUS STANDARD OF CARE IN ADULT PATIENTS WITH LUPUS NEPHRITIS - H.C. Chen, J.J. Lichauco, H.M. Gomez, M. Tee, C. Arroyo, J.L. Lan, Y.F. Fang, Q. Chang, J. Osterloh, A. Miles, E. Chang, A. Mongan, H.A. Kroon Kidney Int Reports
  Lupus nephritis (LN) is an autoantibody-mediated disease potentiated by the classical complement pathway, which is initiated by C1q. The goal of therapy in LN is to prevent chronic kidney disease and end-stage renal disease (ESRD) with anti-inflammatory and immunosuppressive agents, but many (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0682 LNcRNAs IN LN (LUPUS NEPHRITIS) - F. EICHINGER, C.C. Berthier, P.J. McCown, D. Fermin, M. Kretzler Kidney Int Reports
  Lupus Nephritis (LN), is a severe autoimmune disease, characterized by immune complex deposition in the kidney. It has been recently recognized that long noncoding (lnc) RNAs are widely expressed and have key roles in gene regulation, including in lupus and kidneys. We analyzed a human RNAseq (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0673 PREDICTING SALT INTAKE AND ALERTING RENAL FAILURE FROM A SINGLE SPOT URINE TEST IN HEALTHY AND CKD POPULATION: A CASE CONTROL OBSERVATIONAL STUDY - S. KAMATE, I. Veerappan, R. Sethuraman, V. Chandel, S. Patil, R. Ananthasubramani Kidney Int Reports
  The classic ancient Tamil literature “Tirukural” quotes, salt is synonym to love. The analogue extends to salt level in preventing CKD and CVD. Our study attempts to screen and determine markers in predicting 24 hr salt intake from urine spot test. Method adapted was analyzing the urine (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0660 ESKD RISK PREDICTION MODEL IN MULTICENTER CKD COHORT IN CHINA: A DERIVATION, VALIDATION, AND COMPARISON STUDY - M. HUI, J. Ma, H.Y. Yang, X.Z. Zheng, Y.M. Zhang, J.W. Wang, F. Wang, B.X. Gao, L.X. Zhang, M.H. Zhao, J.C. Lv, L. Yang Kidney Int Reports
  In light of the growing burden of CKD (Chronic Kidney Disease), it is of particular importance to us to create disease prediction models that will assist healthcare providers in identifying cases of CKD individual risk and integrate risk-based care for disease progress management. The objective (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0614 HUMAN AMNION-DERIVED MESENCHYMAL STEM CELL TREATMENT FOR A MALE UREMIC CALCIPHYLAXIS PATIENT WITH MULTISYSTEM ANGIOPATHY - F. Li, M. Zeng, C. Ouyang, J. Liu, S. Ning, H. Cui, Y. Yuan, Z. Su, J. Zhou, W. Liu, L. Wang, X. Wang, C. Xing, L. Qin, N. Wang Kidney Int Reports
  Calciphylaxis, mostly occurring in patients with chronic kidney disease (CKD), also named calcific uremic arteriolopathy (CUA), is a rare cutaneous-systemic disease with high mortality and no proven therapy. Here we report a male post-kidney transplantation calciphylaxis patient with extremely (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0607 MODELLING GENETIC POLYCYSTIC KIDNEY DISEASE USING HUMAN PLURIPOTENT STEM CELL-DERIVED KIDNEY ORGANOIDS - L. MENG, Z. Chao, G. Ximing, Z. Tian, N. Mihir Yogesh, A. Cardilla, W. Huamin, W. Yixuan, F. Jia Nee, X. Yun Kidney Int Reports
  Polycystic kidney disease (PKD) is an inherited disorder characterized by progressive expansion of fluid-filled cysts in the kidney. Most of previous studies of PKD are based on animal models which cannot fully translate into human clinical trial. Current therapeutic approaches for managing PKD (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0587 ASSESSMENT OF LV FUNCTION WITH STE VERSUS CONVENTIONAL 2D ECHOCARDIOGRAPHY AND ITS CORRELATION WITH SST2 BIOMARKER IN PATIENTS WITH CHRONIC KIDNEY DISEASE - M.S. shetty, A. mittal, K. kelur, C. manoj, S. rajanna Kidney Int Reports
  Chronic kidney disease (CKD) is defined as kidney damage or an estimated glomerular filtration rate (eGFR) of less than 60 ml/min/1.73 mt2 that lasts for three months or more, regardless of aetiology. (Kidney International Reports 8, 3 (2023))
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  WCN23-0543 ESTABLISH ORGANOID MODELS TO STUDY HUMAN KIDNEY DISEASES - Y. XIA Kidney Int Reports
  The prevalence of chronic kidney disease (CKD) is increasing with an alarming rate, primarily due to the increased incidence of type II diabetes and cardiovascular diseases. Animal models are extremely useful in revealing genetic pathological pathways the are conserved across species. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0535 HUMAN STEM CELL-DERIVED KIDNEY ORGANOID TO MODEL DIABETIC NEPHROPATHY - H. WANG, T. Zhang, A. Cardilla, Y. Xia Kidney Int Reports
  Diabetic nephropathy (DN) is characterized by the presence of albuminuria, glomerular lesions, and loss of glomerular filtration rate (GFR) over time in diabetes patients, representing one of the leading causes of end-stage renal disease (ESRD). Limited achievement has been made towards novel (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0485 THERAPEUTIC EFFECTS OF HUMAN AMNION-DERIVED MESENCHYMAL STEM CELLS ON HYPERCOAGULABILITY IN A UREMIC CALCIPHYLAXIS PATIENT - A. Bian, X. Ye, J. Wang, M. Zeng, J. Liu, K. Liu, S. Ning, X. Xu, Z. Su, J. Zhou, X. Lv, N. Liang, C. Xing, L. Qin, N. Wang Kidney Int Reports
  Calciphylaxis is a rare cutaneous vascular disease with clinical manifestations of intolerable pains, non-healing skin wounds, histologically characterized by calcification, fibrointimal hyperplasia, and thrombosis in microvessels. Currently, there are no approved guidelines for this disease. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0932 REACTIVE OXYGEN SPECIES AND DEGRANULATION LEUKOCYTE FUNCTION DETERMINATION IN ESRD HEMODIALYSIS PATIENTS - A.C. Ramirez Anguiano, S.F. Velasco Ramirez, M.R. Cueto Casillas, L. Donis Maturano, A. Banda Lopez, S. Mendoza Cabrera, B. Bautista Melo, V. Rodriguez Ugarte, M. Gonzalez Franco, M.M. Flores Fonseca MD Kidney Int Reports
  End stage renal disease (ESRD) hemodialysis (HD) patients leads to an inflammatory reaction that initiates as biological protector and mitigates a restoration process. However, persistent inflammation stimulates and triggers free radical formation, generating a continuous cycle between this (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0701 ELEVATED PLASMA OXALIC ACID PROMOTES CHRONIC INFLAMMATION IN STAGE 1-3 CKD PATIENTS - N. Stepanova MD, V. Driianska, L. Snisar, S. Savchenko, M. Kolesnyk Kidney Int Reports
  Recent experimental studies have demonstrated that plasma oxalic acid (POx) increases the secretion of inflammatory factors in chronic kidney disease (CKD) in a dose-dependent manner. In addition, POx has been suspected to induce oxidative stress and inflammation in patients with end-stage (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0541 SPIRULINA MAXIMA EFFECT ON HEMODIALYSIS PATIENTS - S.F. Velasco Ramírez, A.C. Ramirez Anguiano, M.R. Cueto Casillas, L. Donis Maturano, M.M. Flores Fonseca MD, M. Gonzalez Franco, A. Banda Lopez, S. Mendoza Cabrera Kidney Int Reports
  CKD and progressive inflammation states promotes oxidative stress. Spirulina maxima (SM) supplementation has been shown to regulate antioxidant, immunoregulatory and anti-inflammatory properties in renal dysfunction conditions. The objective of this study was to evaluate the effect of Spirulina (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0531 High-fat diet induces kidney damages by decreased hydrogen sulfide production and increased oxidative stress - G. JANG, Y.K. Han, G.B. Lee, M.J. Kong, K.M. Park Kidney Int Reports
  Hydrogen sulfide (H2S), a newly established endogenous gaseous signaling molecule, exerts various biological functions, including the regulation of oxidative stress, which is associated with obesity-related diseases. Patients with obesity present low level of H2S. However, the role of H2S on (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0518 RNAomics OF APOL1 RISK AND NON-RISK ALLELE EXPRESSING PODOCYTES IN HIV MILIEU - V. Sharma, P. Kaur, X. Lan, K. Skorecki, R. Ramachandran, A. Malhotra, P.C. Singhal Kidney Int Reports
  African Americans (AAs) develop chronic kidney diseases (CKD) at 4-5 folds higher rates than European Americans (EAs), and this disparity is over 10 folds in the case of HIV-associated nephropathy (HIVAN). This disparity is mainly due to two risk alleles (G1 and G2) in APOL1 gene in AAs. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0479 TEGOPRUBART FOR THE TREATMENT OF PATIENTS WITH IGA NEPHROPATHY: A SNAPSHOT OF EMERGING DATA FROM AB ONGOING TRIAL - J. Barratt, A. Liew, D. Rizk, L. Willcocks, R. Lafayette, M.G. Wong, V. Tesar, J. BORNSTEIN, C. Mak, H. Reich, S. Tang Kidney Int Reports
  Immunoglobulin A nephropathy (IgAN) is the most common autoimmune nephropathy, with a young age of onset and a slow progressive course. Up to 40% of affected patients progress to kidney failure within 20 years of diagnosis. Therapeutic interventions that delay progression are limited, and more (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0340 Proteomic landscape of the extracellular matrix reveals oxidative stress as a key element of the fibrogenic microenvironment - L. LI, H. Fu, Y. Liu Kidney Int Reports
  Kidney fibrosis typically initiates at certain focal sites after injury, in which the fibrogenic microenviroment is formed in a spatially confined fashion. Of various components of the fibrogenic microenvironment, the extracellular matrix (ECM) plays a central role in orchestrating its (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0046 RASAL2 INITIATES THE PROCESS OF PERITUBULAR CAPILLARY RAREFACTION IN RENAL INTERSTITIAL FIBEROSIS - Y. ZHANG, M. Wei, P. Chen Kidney Int Reports
  Contrary to the vigorous angiogenesis in renal cell carcinoma (RCC), sparse peritubular capillaries are common in renal interstitial fibrosis (RIF) although both of them are in hypoxic microenvironments. To investigate the latent targets of ameliorating angiogenesis deficiency in fibrosis by (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1243 Holistic approach in search for genetic modifiers in thin basement membrane nephropathy - C. Deltas Kidney Int Reports
  A frequent form of familial hematuria is caused by heterozygous mutations in the COL4A3/A4 genes, due to thinner glomerular basement membranes. The prevalence of such mutations is about 1/106 in the general population. While most patients maintain their kidney function, a subset of patients (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1242 Genetic interaction between XBP1 and Pkd1 modulates ADPKD progression - M. Krappitz, C. Pioppini, R. Bhardwaj, E. Duygu, T. Hollmann, S. Somlo, S. Fedeles Kidney Int Reports
  Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common monogenic, life-threatening genetic disorder with 50 percent of the cases leading to end-stage kidney disease in the fifth and sixth decades in life. To date, one therapy (Tolvaptan) has been approved by the FDA for the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1240 COMBINING METFORMIN AND DRUG-LOADED KIDNEY-TARGETING MICELLES FOR POLYCYSTIC KIDNEY DISEASE - E.J. CHUNG Kidney Int Reports
  Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease that leads to eventual renal failure. Metformin (MET), an AMP-activated protein kinase (AMPK) activator already approved for type 2 diabetes, is currently investigated for ADPKD treatment. However, (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1071 GENOME-WIDE ASSOCIATION ANALYSIS OF PROTEIN CODING VARIANTS IN IGA NEPHROPATHY - M. Li, W. YANNA, J. Liu, X.Q. Yu Kidney Int Reports
  IgA nephropathy (IgAN) is a major cause of kidney failure worldwide. To date, at least 8 GWASs have been performed for IgAN with more than 30 susceptibility loci being discovered. GWAS-implicated variants are generally common variants that confer relatively small effects and lie within (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1062 GENETIC TESTING IN PATIENTS WITH TYPICAL AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE AMONG INDIAN SUBPOPULATION - V. VENKATASUBRAMANIAN, J. Sethi, H.S. Kohli, V. Kumar, A.K. Yadav Kidney Int Reports
  Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease worldwide. It is caused primarily by mutations of two genes, PKD1 and PKD2 contributing to 85% of cases with no mutations detected in the rest. More than 1250 and 200 pathogenic germline mutations (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0990 SPECTRUM OF GENETIC VARIANTS IN STEROID-RESISTANT NEPHROTIC SYNDROME AMONG RUSSIAN CHILDREN - A. SMIRNOVA, A. Knyazeva, D. Tsibulskaya, N. Shcherbakova, I. Povolotskaya, L. Prikhodina Kidney Int Reports
  Pediatric steroid-resistant nephrotic syndrome (SRNS) is characterized by a significant genetic heterogeneity with a high risk of progression to end-stage kidney disease in childhood. Recent advances in molecular genetics and widespread use of the next generation sequencing (NGS) technology (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0839 CHRONIC KIDNEY DISEASE-RELATED SINGLE NUCLEOTIDE POLYMORPHISMS (SNPs) AMONG ADULT WEST AFRICANS WITH AND WITHOUT HIV - U. Ekrikpo, K. Mnika, E. Effa, E. Akpan, A. Bello, A. Wonkam, I. Okpechi Kidney Int Reports
  The role of genetics may be implicated in at least a quarter of non-diabetic chronic kidney disease (CKD) cases. Still, it could be as high as 75% depending on the CKD aetiology and setting, with people of Black race more affected. We investigate the association of 22 SNPs (previously reported (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0829 ADTKD-UMOD IN A GIRL WITH A DE NOVO MUTATION: A CASE REPORT - M. LI, Y. Li, L. Jiang, Z. Song, X. Yu, H. Wang, Y. Ren, S. Wang, X. Zhou, L. Yang, H. Zhang Kidney Int Reports
  Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a rare genetically heterogeneous disorder characterized by slowly progressive loss of kidney function, and bland urinary sediment with absent or trace proteinuria. UMOD is the most important pathogenic gene and compared to other (...) (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0795 CRISPR/Cas9-mediated A4GALT suppression rescues Fabry disease phenotypes in a kidney organoid model - S. Cui, S. Yoo Jin, F. Xianying, L. Hanbi, L. Sun Woo, Y. Chul Woo, B.H. CHUNG Kidney Int Reports
  The objective of this study was to investigate whether CRISPR/Cas9-mediated suppression of A4GALT could recue phenotype of Fabry disease nephrophy (FDN) using human induced pluripotent stem cells (hiPSCs) derived kidney organoid (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0781 Early Onset Nephrotic Syndrome: Expanding the Genetic Spectrum - J. Sharma, A. Saha, A. Ohri, F. Shah, P. Bhansali, K. Sathe, M. Matnani, J. Dave, B. Jain, V. More, P. Chajjed, P. Deore, M. Agarwal, U. Ali Kidney Int Reports
  Eighty-five percent of infants with congenital nephrotic syndrome (CNS, onset of NS at age less than 3 months) and 66 % of infantile NS (INS, onset between 3 months to 1year) are likely to have a monogenic etiology. Similar to most genetic disorders, there exists a significant genetic (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0777 Bioinformatics-based analysis and identification of therapeutic targets for papillary cell renal cell carcinoma - Y. Li, H. TU, N. Song, W. Xiong Kidney Int Reports
  Papillary renal cell carcinoma (pRCC) is the most vulgar type of renal cell cancer, and there are no effective treatment options to cure pRCC. Therefore, exploring its therapeutic targets may supply new directions for the therapy of (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0596 Prevalence of APOL1 gene polymorphisms in patients with kidney disease in South India- A single-center observational study - C.M. BALASUBRAMANIAN, G. Natarajan, G. Senthilkumaran, P. Devaraju, V.D. Rajarathinam, V. Murugesan, J. V s, V. Arumugam, T.M. Lamech, S. Dakshinamoorthy, D. Thanigachalam Kidney Int Reports
  Incidence and prevalence of many types of severe kidney disease are much higher in Black individuals than most other ethnic groups.Much of this disparity is attributed to nephropathic APOL1 gene alleles found only in individuals with recent African ancestry. These variants greatly increase (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0585 THE FIRST CASE DNAJB11 ASSOCIATED NEPHROPATHY IN GREECE (AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE-6/ ADPKD-6) - K. Dermitzaki, I. Petrakis, E. Drosataki, M. Papapanagiotou, C. Pleros, D. Lygerou, I. Stavrakaki, M. Mitrakos, N. Papadakis, M. Konidaki, S. Maragou, N. Kroustalakis, D. Varvouti, A. Androvitsanea, K. Stylianou Kidney Int Reports
  Many patients with a family history of chronic kidney disease (CKD) present multiple cystic kidney lesions without suffering from classical adult polycystic kidney disease (ADPKD). DNAJB11-associated nephropathy was first described in 2018 in 7 kindreds with monoallelic mutations in the DNAJB11 (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0477 Repurposing of selective inhibitor of HDAC1/2 for obese hypertension - J.I. KIM Kidney Int Reports
  Dysregulation of renal angiotensinogen is a critical factor for the development of hypertension. (Kidney International Reports 8, 3 (2023))
• 00:00
  WCN23-0391 THE CLINICAL CHARACTERISTICS AND KIDNEY OUTCOME IN CHINESE PATIENTS WITH TYPICAL AND ATYPICAL POLYCYSTIC KIDNEY DISEASE - W.W.S. Fung, C.C. Szeto, K.M. Chow, P. Cheng, V. Kwong, S. Lau, W.F. Pang, W. Chu, A. Ong, O. Devuyst, P. Li Kidney Int Reports
  Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and it accounts for about 10% of end-stage kidney disease (ESKD). The management of ADPKD remains a challenge with variable and uncertain genotype-phenotype correlations, which may lead to a delay (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0299 Electronic Health Record based Nephrotic Syndrome Genomic Discovery using the Mass General Brigham (MGB) Biobank - J. WONGBOONSIN, A. Greenberg, S. Nigwekar, M. Sampson Kidney Int Reports
  Published studies demonstrating the value of genetic stratification in nephrotic syndrome (NS) have often focused on children or research cohorts selected for specific characteristics, such as having steroid resistant NS. The prevalence and clinical correlates of known genetic forms of NS in (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0202 POLYGENIC RISK SCORE FOR CKD: ASSOCIATION BETWEEN DYSLIPIDEMIA AND THE RISK OF INCIDENT CKD AFFECTED BY GENETIC SUSCEPTIBILITY - B. WEON, J. Lee, C.S. Lim, J.P. Lee, S. Won Kidney Int Reports
  Polygenic risk score (PRS) provides information of the overall contribution of numerous genetic variants on disease outcomes. The effect of dyslipidemia on kidney disease outcome are inconsistent according to the individual’s clinical characteristics including estimated glomerular filtration (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0201 AIR POLLUTION, GENETIC FACTORS AND THE RISK OF INCIDENT CHRONIC KIDNEY DISEASE: A PROSPECTIVE STUDY OF POLYGENIC RISK SCORE ANALYSIS IN THE UK BIOBANK - B. WEON, J. Lee, C.S. Lim, J.P. Lee, S. Won Kidney Int Reports
  The polygenic risk score (PRS) has enabled us to stratify an individual's genetic risk for polygenic disease and also investigate the interaction between genetic factor and other risk factors. Air pollution has been focused as a novel environmental risk factor for kidney diseases, but the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0196 “GENETICS IN NEPHROLOGY: IS THIS THE PATH FORWARD? A PROSPECTIVE STUDY FROM A TERTIARY CARE CENTER IN SOUTH INDIA” - K. GIRI, M. Sahay, K. Ismal Kidney Int Reports
  The genetics in kidney diseases have undergone explosive growth in recent years due to significant advances in sequencing technology and genetics methodology. Multiple studies suggest that 10% of the adult ESKD and 30% of the pediatric population have identifiable genetic causes. The aims of (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0160 FABRY NEPHROPATHY: SWITCH FROM ENZYME REPLACEMENT THERAPY TO ORAL CHAPERONE MIGALASTAT - F.J. PERRETTA Kidney Int Reports
  Fabry disease (FD) is a lysosomal storage disorder caused by the absence or deficiency of the ?-galactosidase-A enzyme (?-gal-A). The result is the complex glycolipids accumulation in body fluids and different tissues, mainly globotriaosylceramide and globotriaosylsphingosine (Lyso-Gb3). Cardiac, (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0159 ENPP6 IS A POTENTIAL NOVEL CANDIDATE GENE FOR MONOGENIC CONGENITAL ANOMALIES OF THE KIDNEYS AND URINARY TRACT - N.D. MERTENS, K. Kano, L.M. Merz, S. El Desoky, J. A Kari, H. Gyung Kang, S. Cingöz, S. Shril, J. Aoki, F. Hildebrandt Kidney Int Reports
  Congenital Anomalies of the Kidneys and Urinary Tract (CAKUT) are the leading cause of chronic kidney disease before 25 years of age. CAKUT has high morbidity, accounting for ~40% of childhood end-stage renal diseases (Murugapoopathy and Gupta, Clin J Am Soc Nephrol, 2020). Enpp6 is a (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0155 Genetic Screening of the Childhood and Adolescence-onset of Steroid Resistant Nephrotic Syndrome - L. TRAN NGUYEN TRUC, H. Ueda, Q. Tran Thuy Huong, T. Kimata, C. Sato, M. Hashiyada, K. Sugimito, M. Hattori, K. Nozu, H. Tsukaguchi Kidney Int Reports
  Steroid-resistant nephrotic syndrome (SRNS) is a clinically and genetically heterogeneous disorder caused by either genetic or immunological factors or their combination. Approximately 30-40% of patients with SRNS make a fast progression to end-stage renal disease (ESRD). SRNS represents the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0079 The Obliquity of the Uncommon: A Case Report on Renal Cell Carcinoma, Clear Cell Type with Secondary Polycythemia In a Young Male - H.C. BEJARASCO Kidney Int Reports
  Clear cell renal cell carcinoma is the most common cell type of renal cell carcinoma accounting 2% of all malignancies. Despite the improvement in the diagnosis and management in renal cell carcinoma in the past two decades, it still remains as one of the most lethal urologic malignancy. Most (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1194 CHRONIC KIDNEY DISEASE IN SICKLE CELL ANEMIA CHILDREN: THE RELEVANCE OF REPEATED MEASURES ACCORDING TO KDIGO DEFINITION - A. NKOY, F. Mumaka, F. Talu, T. Matoka, A. Ngonde, R. Kitenge, L. Tshilolo, L.P. Van den Heuvel, V. Labarque, P. Ekulu, E. Levtchenko Kidney Int Reports
  Chronic kidney disease (CKD) is one of the leading causes of mortality in patients with sickle cell anemia (SCA). Albuminuria is known as an early manifestation and predictor of the progression to CKD in these patients. Several studies reported the prevalence of albuminuria in SCA children (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1090 DRUG USE PATTERNS AMONG PATIENTS ATTENDING CHRONIC KIDNEY DISEASE CLINIC AT THE UNIVERSITY HOSPITAL - S. Khananthai, A. Porncatatak, M. Jampong, N. Ingpongpun, S. Pinsamsay, S. Chumnumwat, S. SUKKHA Kidney Int Reports
  The prevalence of patients with kidney disease has been continuously increasing in South East Asia and worldwide. In Thailand, several hospitals have implemented a national policy service to promote the patient care process for patients with chronic kidney disease (CKD). In CKD clinic, (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0776 BARRIERS TO ACCESSING ESSENTIAL MEDICINES IN NEPHROLOGY AND RELATED NON-COMMUNICABLE DISEASES: A SCOPING REVIEW - M. Wong, G. Nakhoul, V. Calice-Silva, E.K. Tannor, V. Kumar, M.I. Abdul Hafidz, R. Chanchlani, T. Chen, U.E. Ekrikpo, A. Francis, R. Kalyesubula, S. Karam, N. Pereira-Kamath, E. Wijewickrama, V. Jha Kidney Int Reports
  Access to safe, effective, quality, and affordable essential medicines (EM) for all is one of the World Health Organization’s Sustainable Development Goals for health. However, access to EM for the treatment of non-communicable diseases (NCDs) is lacking in many low-income (LICs) and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0676 EFFICACY AND SAFETY OF STANDARD VS HIGH DOSE BICARBONATE SUPPLEMENTATION IN CHRONIC KIDNEY DISEASE OF UNKNOWN AETIOLOGY –AN OPEN-LABEL RANDOMISED CONTROL TRIAL - P. P S, S. Raju, K. Manoharan, J. Sahoo, V. Subramaniyam, B. Vairappan, S. Parameswaran Kidney Int Reports
  Bicarbonate supplementation has been found to arrest the progression of Chronic Kidney Disease (CKD). The optimal, safe, tolerable upper range of bicarbonate supplementation needs to be tested with randomised trials. The present study compared the safety of two levels of bicarbonate correction (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0580 ANALYSIS OF POLYPHARMACY AND DRUG INTERACTIONS PRESCRIBED TO PATIENTS WITH CHRONIC KIDNEY DISEASES IN NEPHROLOGY DEPARTMENT - A. ASSAN, A. Gaipov, Z. Kerimbayeva, D. Syssoyev, A. Issayev, M. Madikenova, I. Moldaliyev, D. Sychev, M. Aljofan Kidney Int Reports
  Multiple drug prescriptions and inappropriate dose adjustments in different stages of CKD remains one of the main factors leading to adverse drug interactions, accumulation of end metabolites, nephrotoxicity and progression to ESRD. We aimed to study polypharmacy and potentially harmful (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0325 Preliminary Efficacy and Safety results of Accelerated Versus Standard Hepatitis B vaccination schedules among Advanced Chronic Kidney Disease patients: A Randomized Controlled Trial - J. KITTRAKULRAT, K. Tiankanon, K. Tiranathanagul, J. Vanichanan, N. Townamchai Kidney Int Reports
  Vaccination against hepatitis B virus (HBV) is crucial for all seronegative advanced chronic kidney disease (CKD) patients for protection during dialysis and preparing for transplantation. HBV vaccination program for CKD patients is required 6 months to be completed. The accelerated HBV (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0121 Serum Urea, Electrolytes, Creatinine, and Estimated Glomerular Filtration Rates in Patients with Chronic Kidney Disease at initiation of Haemodialysis in a Referral Hospital in Kenya - A. ONYANGO, S. McLigeyo, A. Mwango, D. Otieno, J. Ngigi, P. Chemutai, D. Irungu, S. Kabinga Kidney Int Reports
  Advanced chronic kidney disease (CKD) is heralded by abnormalities in serum urea, creatinine, electrolytes, endocrine, metabolic among others. At end stage kidney disease (ESKD), the abnormalities are so profound that the patients have to depend on kidney replacement therapies (KRT) including (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-1012 COMMUNITY-BASED INTERVENTION FOR MONITORING OF SALT INTAKE IN HYPERTENSIVE PATIENTS: A CLUSTER RANDOMIZED CONTROLLED TRIAL - P. SONUCH, S. Kantachuvesiri, W. Aekplakorn Kidney Int Reports
  Sodium is an essential nutrient for humans, but excessive sodium intake is related to high blood pressure and increases the risk of cardiovascular disease. A dietary sodium intake that exceeds the recommended daily amount of 5 grams of salt or 2,000 milligrams of sodium is a significant risk (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0959 Benefits of information technology as web based application to calculate and evaluate blood pressure in children - A. Lumpaopong, B. Kasom Kidney Int Reports
  Evaluation of hypertension in children is differ from adults since there are many factors include age, gender, and height that provide the different results. In the year 2017, American Academy of Pediatrics (AAP) develop guideline for screening and management of high blood pressure (BP) in (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0664 Long-term average level and variation of sodium excretion and progression of chronic kidney disease, a single center-based cohort study - J. Wang, Y. Wang Kidney Int Reports
  Restriction of sodium intake to (Kidney International Reports 8, 3 (2023))
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  WCN23-0073 Comparison of Morning and Evening Antihypertensive Drug Administration on Albuminuria in Hypertensive Patients (The MORE trial): A Randomized Control Trial - T. TRAKARNVANICH, T. Ngamvichchukorn Kidney Int Reports
  Hypertension is a major risk factor for cardiovascular disease, stroke, and mortality among millions of people worldwide. Hypertension causes albuminuria and is associated with cardiovascular and renal risks. Hypertensive patients usually exhibit marked diurnal variations in the onset of (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0016 INTENSIVE BLOOD PRESSURE CONTROL AND CADIOVASCULAR OUTCOMES IN ELEDERLY PATIENTS : A SECONDARY ANALYSIS OF SPRINT STUDY BASED ON 60-YEARS AGE CUT-OFF - S. Cheema, M. Cheema, S.S. Cheema, Z. Butt Kidney Int Reports
  In the original SPRINT article age was categorized at 75 years. However, in many previous clinical trials on hypertension and in JNC 8 guidelines, age has been categorized at 60 years. In this re-analysis of SPRINT trial, we have re-categorized age (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0745 Chinese collaborative study of survival analysis in 980 patients with AL amyloidosis - H. Yau, L. Zhong, S. Li, P. Liao, J. Xie, S. Lin, Y. Chen, H. Fei, H. Liu, J. Li, J. Li, W. Wang Kidney Int Reports
  The prognosis of patients with light-chain amyloidosis (AL) has been improved markedly in past decade in China, whether the current staging systems are suitable to predict overall survival (OS) of the patients remain undetermined. (Kidney International Reports 8, 3 (2023))
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  WCN23-0706 FAMILY HISTORY OF ALPORT SYNDROME WITH SPECTRUM OF CHRONIC KIDNEY DISEASE, DIALYSIS AND TRANSPLANTATION - N. BASHIR, I. Al Shamsi, H. Al Shamsi, E. Khater Kidney Int Reports
  Alport syndrome should be considered in the differential diagnosis of patients with persistent microhematuria. Electron microscopic examination of renal tissue remains the most widely available and applied means for diagnosing AS. The presence of diffuse thickening and multilamellation of the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0666 EFFICACY AND SAFETY OF DAPAGLIFLOZIN IN PATIENTS WITH CHRONIC KIDNEY DISEASE ACROSS THE SPECTRUM OF FRAILTY - P. Vart, J. Butt, J. Niels, G.M. Chertow, D.C. Wheeler, J.J.V. McMurray, A.M. Langkilde, H. Lambers Heerspink Kidney Int Reports
  Frail patients are perceived to benefit less from healthcare services and are less likely to receive medical and surgical interventions than non-frail patients. In this study, we examined the safety and efficacy of dapagliflozin by levels of frailty in patients with chronic kidney disease (CKD) (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0584 A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE 3 STUDY TO ASSESS THE EFFICACY AND SAFETY OF IPTACOPAN IN IDIOPATHIC IMMUNE COMPLEX-MEDIATED MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS (IC-MPGN) - U.K. VELDANDI, D. Kavanagh, M. Vivarelli, A. Bomback, Y. Wang, K. Bogdanowicz, N. Webb, M. Meier, R.J.H. Smith Kidney Int Reports
  IC-MPGN is a fast-progressing kidney disease that may be idiopathic or secondary to chronic infection, autoimmune disorders, or monoclonal gammopathies. Idiopathic IC-MPGN is ultra-rare and has a comparable clinical course to complement 3 glomerulopathy (C3G), which is also characterized by (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0570 SARCOPENIA, FRAILTY AND FGF23 IN CHRONIC KIDNEY DISEASE - L. WONG, D. Nguyen, R. Kenny, J. Howard, L.P. McMahon Kidney Int Reports
  Sarcopenia is defined as loss of muscle mass, strength and/or performance, while frailty is a syndrome characterised by a reduction in functional reserve, leading to an increased risk of adverse outcomes upon exposure to stressors. Both sarcopenia and frailty are strongly associated with (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0567 PERTURBATIONS IN FREQUENCY AND FUNCTION OF CLASSICAL AND EXHAUSTED MEMORY B CELLS IN LUPUS NEPHRITIS - L. ZHU Kidney Int Reports
  Repeated relapses is associated with increased risk of renal failure and cumulative treatment toxicities in lupus nephritis (LN) patients. Various B cell abnormalities have been implicated in the pathogenesis of LN, and our previous studies have demonstrated memory B cells assume pathogenic (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0566 RENAL INVOLVEMENT IN PRIMARY SJOGREN’S SYNDROME - S. Sanjeevani, P. PRASAD, S. Bagai, D. Khullar Kidney Int Reports
  Renal involvement in Primary Sjogren's syndrome (pSS) is often missed due to its insidious presentation. The aim of this study was to describe the renal manifestations in patients with pSS. (Kidney International Reports 8, 3 (2023))
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  WCN23-0555 PERTURBATIONS IN FREQUENCY AND FUNCTION OF CLASSICAL AND EXHAUSTED MEMORY B CELLS IN LUPUS NEPHRITIS - L. ZHU Kidney Int Reports
  Repeated relapses is associated with increased risk of renal failure and cumulative treatment toxicities in lupus nephritis (LN) patients. Various B cell abnormalities have been implicated in the pathogenesis of LN, and our previous studies have demonstrated memory B cells assume pathogenic (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0469 IgA NEPHROPATHY AND RISKS OF KIDNEY AND CARDIOVASCULAR EVENTS AND DEATH: THE KNIGHT STUDY - T. TAN, R. Parikh, A. Mahapatra, R. Perkins, A. Go Kidney Int Reports
  IgA nephropathy (IgAN) leads to inflammation and kidney fibrosis, is the most common type of glomerulonephritis globally, and contributes significantly to the global burden of chronic kidney disease (CKD) and end-stage kidney disease (ESKD). Yet, few population-based data exist from the U.S. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0468 URINARY TRACT INFECTIONS IN CHRONIC KIDNEY DISEASE PATIENTS - A ROMANIAN CENTER EXPERIENCE - E. Cuiban, D. Radulescu, C. David, F.L. Turcu, C. Bogeanu, L.F. Feier, S.D. Onofrei, I.A. Vacaroiu Kidney Int Reports
  The increasing global prevalence of chronic kidney disease (CKD) is an important public health issue. Infectious complications are an important source of morbidity and mortality in this population and impaired kidney function is a known risk factor for antimicrobial resistance. Urinary tract (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0412 EFFECT OF IPTACOPAN ON PROTEINURIA AND COMPLEMENT BIOMARKERS OVER TIME IN IgA NEPHROPATHY - J. Barratt, B.H. Rovin, H. Zhang, D.V. Rizk, N. Kashihara, B.D. Maes, H. Trimarchi, B. Sprangers, M. Meier, D. Kollins, G. Junge, J. Milojevic, O. Papachristofi, V. Perkovic Kidney Int Reports
  IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide. The alternative complement pathway (AP) plays a key role in the pathogenesis of IgAN. Iptacopan (LNP023) is an oral, first-in-class, highly potent proximal complement inhibitor that specifically binds factor (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0410 THE EFFECT OF BREASTFEEDING ON URINARY TRACT INFECTION IN INFANTS - M.H. CHO Kidney Int Reports
  Word Health Organization recommends exclusive breastfeeding. It is the ideal source of nutrition for neonates and infants. In addition, it contains antibodies, cytokines, antimicrobial substances, and specific immunity cells. It is known to have a protective effect against most infections. (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0403 AN OPEN-LABEL, NON-RANDOMIZED EXTENSION STUDY TO EVALUATE LONG-TERM EFFICACY, SAFETY, AND TOLERABILITY OF LNP023 IN SUBJECTS WITH C3 GLOMERULOPATHY: INTERIM ANALYSIS OF PHASE 2 STUDY - C.M. Nester, U. Eisenberger, A. Karras, M. le Quintrec-Donnette, L. Lightstone, M. Praga, G. Remuzzi, M. Jose Soler, J. Liu, M. Meier, R. Tawfik, G. Junge, A. Biondani, A. J Trapani, N. Webb, E. K Wong Kidney Int Reports
  Iptacopan (LNP023) is an oral, first-in-class, selective inhibitor of factor B, a key component of the alternative complement pathway (AP). We have previously reported data from a Phase 2 study in native and recurrent Complement 3 glomerulopathy (C3G) showing that 12 weeks iptacopan treatment (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0397 EFFECT OF CANAGLIFLOZIN IN NON-DIABETIC OBESE PATIENTS WITH ALBUMINURIA: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL - P. Greeviroj, P. Puapatanakul, J. Phannajit, K. Takkavatakarn, W. Kittanamongkolchai, P. Boonchaya-Anant, P. Katavetin, K. Praditpornsilpa, P. Susantitaphong Kidney Int Reports
  Canagliflozin, a sodium-glucose cotransporter 2 inhibitor, has been shown to improve renal outcomes in diabetic patients independent of a glucose-lowering effect. A renal protective effect in non-diabetic patients, particularly those with albuminuric kidney disease associated with obesity, has (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0396 I SEE YOUR TRUE COLOR: AN UNCOMMON MANIFESTATION OF URINARY TRACT INFECTION IN AN ADULT WOMAN PRESENTING WITH PURPLE URINE BAG – A CASE REPORT - A.L. CASIO, E. Polito Kidney Int Reports
  Although purple discoloration on the plastic disposable urinary catheter bag is uncommon, a purple urine bag syndrome or PUBS has been reported to be common in institutionalized or hospitalized patients who have long-term indwelling urinary catheter use. When faced with this condition, (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0373 ALTERNATIVE COMPLEMENT PATHWAY PHARMACODYNAMICS OF IPTACOPAN - R. SCHMOUDER, G. Junge, J. Milojevic, P.K. Nidamarthy, K. Kumatycki Kidney Int Reports
  Iptacopan (LNP023) is a first-in-class, oral, low molecular weight, Factor B inhibitor being developed for the treatment of diseases associated with activation of the alternative complement pathway. Current Phase III studies of iptacopan include paroxysmal nocturnal hemoglobinuria, C3 (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0372 ASSESSMENT OF DRUG INTERACTIONS WITH IPTACOPAN - R. SCHMOUDER, B. Shah, A. Taylor, P.K. Nidamarthy, K. Kulmatycki Kidney Int Reports
  Iptacopan (LNP023) is a first-in-class, oral, low molecular weight, Factor B inhibitor being developed for the treatment of diseases associated with activation of the alternative complement pathway. Current Phase III studies of iptacopan include paroxysmal nocturnal hemoglobinuria, C3 (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0371 ABSORPTION AND DISPOSITION OF A FIRST-IN-CLASS ALTERNATIVE COMPLEMENT PATHWAY FACTOR B INHIBITOR: IPTACOPAN - R. SCHMOUDER, B. Shah, M. Hackling, A.D. James, P.K. Nidamarthy, K. Kulmatycki Kidney Int Reports
  Iptacopan (LNP023) is a first-in-class, oral, low molecular weight, Factor B inhibitor being developed for the treatment of diseases associated with activation of the alternative complement pathway. Current Phase III studies of iptacopan include paroxysmal nocturnal hemoglobinuria, C3 (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0309 RELATIONSHIP BETWEEN ORAL HEALTH STATUS AND PHYSICAL FUNCTION IN PATIENTS UNDERGOING HEMODIALYSIS: A CROSS-SECTIONAL STUDY - S. Nikkawa, K. Imamura, S. Yoshikoshi, T. Nakajima, J. Uchida, N. Fukuzaki, A. Tobita, M. Harada, S. Osada, A. Matsunaga Kidney Int Reports
  Lifestyle-related diseases, including diabetes and chronic kidney disease, are associated with oral health status. It has been highlighted that patients undergoing hemodialysis (HD) are prone to deterioration of oral function, leading to a worse life expectancy. Recently, oral frailty, which is (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0273 IDENTIFICATION AND EXPRESSION LEVEL OF CHAPERONES IN RENAL AMYLOID DEPOSITS OF DIFFERENT AMYLOIDOSIS - S. WANG, X. Zhang, F. Zhou, S. Wang Kidney Int Reports
  Amyloidosis is a protein conformational disease caused by the deposition of extracellular insoluble fibrils which derived from the misfolded precursor proteins. The kidney is the organ most commonly involved in amyloidosis, the common types of renal amyloidosis include immunoglobulin light (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0269 PREVALENCE OF CHRONIC KIDNEY DISEASE AND ITS RISK FACTORS IN PATIENTS WITH TAKAYASU ARTERITIS - N. Bulanov, V. Logina, A. Efimova, N. Vlasova, K. Makarova, E. Filatova, A. Skvortsov, P. Novikov, S. Moiseev Kidney Int Reports
  Takayasu arteritis (TA) is a large-vessel systemic vasculitis predominantly affecting aorta and its branches. TA is rarely associated with glomerular or tubulointerstitial inflammation, however chronic kidney damage resulting from renal artery involvement and/or refractory hypertension can (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0181 CLINICAL PRESENTATION, EPIDEMIOLOGY, MANAGEMENT, AND FOLLOW-UP FOR PATIENTS DIAGNOSED WITH BARTTER SYNDROME: A SYSTEMATIC REVIEW OF CASE REPORTS AND CASE SERIES - R.K. Qasba, A.C.F. Bucharles, M.V.F. Piccoli, P. Sharma, A. Banga, B. Kamaraj, F.A. Nawaz, H.J. Kumar, M.A. Happy, G.S.K. Jagirdhar, M.Y. Essar, P. Garg, S.T. Reddy, K. Rama, R. Kashyap Kidney Int Reports
  Bartter syndrome (BS) is a relatively new and rare inherited disease identified as autosomal recessive in nature and characterized by a defect in transport mechanisms in the thick ascending loop of Henle. It usually manifests as a hypokalemic metabolic alkalosis with occasional hypochloremic (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0178 AWARENESS OF CKD AND ITS RISK FACTORS IN NEWLY INDEPENDENT STATES AND RUSSIA ISN REGIONS: A POPULATION-BASED SURVEY - A. MUXUNOV, N. Bulanov, S. Makhmetov, O. Sharapov, S. Abdullaev, O. Loboda, D. Aiypova, E. Haziyev, I. Rashidov, I. Tchokhonelidze, A. Gaipov Kidney Int Reports
  Development and implementation of CKD prevention and screening programs may help to reduce the proportion of people having CKD and its complications. Assessment of public knowledge of CKD is an essential step on the way of prevention and screening programs development. Our aim was to estimate (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0163 CAN YOUNG CHILDREN SWALLOW MULTIPLE COATED MINI-TABLETS? RESULTS FROM AN OPEN-LABEL, SINGLE-DOSE CROSSOVER STUDY - I. Sessler, N.J. Webb, P. Lustenberger, R. SIVASUBRAMANIAN, G. Loforese, J. Muench, H.M. Bosse, V. Klingmann Kidney Int Reports
  Iptacopan (LNP023) is an orally administered proximal complement inhibitor that specifically binds factor B and inhibits the alternative complement pathway. It is in clinical development for the treatment of complement-mediated diseases in adults and children. The physicochemical properties of (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0129 Indoxyl sulfate suppressed glycolysis related to apoptosis in human astrocyte - H.W. GIL, S. Park, N.J. Cho, E.Y. Lee Kidney Int Reports
  Neurologic complications, such as cognitive and emotional dysfunction, were frequently observed in patients with chronic kidney disease(CKD). Given previous knowledge, uremic toxins have a role in the pathogenesis of CKD-associated cognitive impairment. Because astrocytes contribute to the (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0127 KIDNEY OUT COMES IN SUDANSES CHILDREN WITH LUPUS NEPHRITIES - N. ALLAM, A. abdelaal Kidney Int Reports
  Systemic lupus erythematosus (SLE) is a chronic inflammatory condition that affects numerous organs. Involvement of the kidneys by lupus nephritis (LN) is one of the most severe clinical manifestations observed in individuals with SLE. LN is more frequent and severe in pediatric patients and (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0109 MANAGEMENT OF ASYMPTOMATIC ANGIOMYOLIPOMA IN PREGNANCY - H. AL SHAMSI, I. Al Shamsi, N. Bashir Kidney Int Reports
  Angiomyolipomas (AMLs) are benign neoplasms composed of different types of tissue like blood vessels, smooth muscles, and adipose. Most AMLs are benign but malignant transformation has been reported (1). Estrogen and progesterone enhances the growth of renal AMLs among patients on hormonal (...) (Kidney International Reports 8, 3 (2023))
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  WCN23-0052 THE EFFECT OF SGLT2 INHIBITORS TREATMENT ON PROTEINURIA IN PATIENTS WITH IgA NEPHROPATHY - Y. DONG, L. Liu, S. Shi, X. Zhou, J. Lv, H. Zhang Kidney Int Reports
  Designed to ameliorate the blood glucose burden of patients with diabetes, sodium-glucose cotransport 2 inhibitors (SGLT2i) have attracted increasing attention over recent years. More and more evidence proved that SGLT2i could protect the kidney from renal disease progression independent of the (...) (Kidney International Reports 8, 3 (2023))