1 January

J Hypertens http://journals.lww.com/jhypertension/

• 07:00
  The effect of continuous positive airway pressure on patients with resistant and refractory hypertension: lessons from the HIPARCO programme - Martinez-Garcia, Miguel Angel J Hypertens
  No abstract available -- EDITORIAL
• 07:00
  Advanced imaging tools for evaluating cardiac morphological and functional impairment in hypertensive disease - Lembo, Maria; Manzi, Maria Virginia; Mancusi, Costantino; Morisco, Carmine; Rao, Maria Assunta Elena; Cuocolo, Alberto; Izzo, Raffaele; Trimarco, Bruno J Hypertens
  Arterial hypertension represents a systemic burden, and it is responsible of various morphological, functional and tissue modifications affecting the heart and the cardiovascular system. Advanced imaging techniques, such as speckle tracking and three-dimensional echocardiography, cardiac (...) -- REVIEW AND META-ANALYSIS
• 07:00
  Neuroadrenergic activation in obstructive sleep apnoea syndrome: a new selected meta-analysis - revisited - Biffi, Annalisa; Quarti-Trevano, Fosca; Bonzani, Matilde; Seravalle, Gino; Corrao, Giovanni; Mancia, Giuseppe; Grassi, Guido J Hypertens
  Background: Neuroadrenegic overdrive occurs in obstructive sleep apnoea syndrome (OSAS). However, the small sample size of the microneurographic studies, heterogeneity of the patients examined, presence of comorbidities, represented major weaknesses not allowing to precisely define the main (...) -- REVIEW AND META-ANALYSIS
• 07:00
  Does exercise stress testing carry an incremental prognostic value beyond resting office blood pressure? - Motiejunaite, Justina; Vidal-Petiot, Emmanuelle J Hypertens
  No abstract available -- EDITORIAL COMMENTARIES
• 07:00
  Cardiovascular risk stratification: how important is the hypertensive response to exercise? - Cuspidi, Cesare; Tadic, Marijana J Hypertens
  No abstract available -- EDITORIAL COMMENTARIES
• 07:00
  Sympathetic activation by obstructive sleep apnea: a challenging ‘off-label’ meta-analysis - Floras, John S.; Wilkinson, Jack J Hypertens
  No abstract available -- EDITORIAL COMMENTARIES
• 07:00
  Activation of the intestinal tissue renin-angiotensin system by transient sodium loading in salt-sensitive rats - Ryuzaki, Masaki; Miyashita, Kazutoshi; Sato, Masaaki; Inoue, Hiroyuki; Fujii, Kentaro; Hagiwara, Aika; Uto, Asuka; Endo, Sho; Oshida, Takuma; Kinouchi, Kenichiro; Itoh, Hiroshi J Hypertens
  Background: The renal tissue renin-angiotensin system is known to be activated by salt loading in salt-sensitive rats; however, the response in other organs remains unclear. Method: Spontaneously hypertensive rats were subjected to normal tap water or transient high-salt-concentration water (...) -- ORIGINAL ARTICLES
• 07:00
  Intrarenal pelvic bradykinin-induced sympathoexcitatory reno-renal reflex is attenuated in rats exposed to chronic intermittent hypoxia - AlMarabeh, Sara; Lucking, Eric F.; O’Halloran, Ken D.; Abdulla, Mohammed H. J Hypertens
  Objective: In this study, we hypothesized that excitatory reno-renal reflex control of sympathetic outflow is enhanced in rats exposed to chronic intermittent hypoxia (CIH) with established hypertension. Methods: Under anaesthesia, renal sensory nerve endings in the renal pelvic wall were (...) -- ORIGINAL ARTICLES
• 07:00
  Pulse wave velocity in South African women and children: comparison between the Mobil-O-Graph and SphygmoCor XCEL devices - Kolkenbeck-Ruh, Andrea; Soepnel, Larske Marit; Kim, Andrew Wooyoung; Naidoo, Sanushka; Smith, Wayne; Davies, Justine; Ware, Lisa Jayne J Hypertens
  Background: Carotid-femoral pulse wave velocity (PWV) is the gold-standard noninvasive measure of arterial stiffness. Data comparing tonometry-based devices such as the SphygmoCor XCEL to simpler brachial-cuff-based estimates of PWV, such as from the Mobil-O-Graph in African populations are (...) -- ORIGINAL ARTICLES
• 07:00
  Optimal target blood pressure for major adverse cardiovascular and cerebrovascular events in hypertensive patients: a nationwide population-based study - Kim, Seon-Mi; Kim, Do-Hyang; Ryu, Dong-Ryeol; Lee, Soojin; Kim, Yaerim; Park, Sehoon; Cho, Semin; huh, Hyuk; Hwang, Jinseub; Lee, Jung-Pyo; Han, Seung-Seok; Lee, Hajeong; Kim, Dong-Ki; Joo, Kwon-Wook; Lim, Chun-Soo; Kim, Yon-Su; Oh, Hyung Jung J Hypertens
  Background: Generalizing an ‘optimal’ blood pressure (BP) level for individuals with hypertension remains controversial due to the implementation of different medical guidelines. This study investigated the association of BP with major adverse cardiovascular and cerebrovascular events (MACCE) and (...) -- ORIGINAL ARTICLES
• 07:00
  Elevated S100A9 in preeclampsia induces soluble endoglin and IL-1? secretion and hypertension via the NLRP3 inflammasome - Ozeki, Ayae; Oogaki, Yuka; Henmi, Yuka; Karasawa, Tadayoshi; Takahashi, Masafumi; Takahashi, Hironori; Ohkuchi, Akihide; Shirasuna, Koumei J Hypertens
  Objectives: Maternal systemic and placental inflammatory responses participate in the pathogenesis of hypertensive disorders of pregnancy including preeclampsia, a pregnancy-specific syndrome, although the role of inflammation remains unclear. The NLRP3 inflammasome has been implicated in the (...) -- ORIGINAL ARTICLES
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  Predicted cardiovascular risk for United States adults with diabetes, chronic kidney disease, and at least 65 years of age - Jaeger, Byron C.; Sakhuja, Swati; Hardy, Shakia T.; Akinyelure, Oluwasegun P.; Bundy, Joshua D.; Muntner, Paul; Whelton, Paul K. J Hypertens
  Background: The 2017 American College of Cardiology/American Heart Association blood pressure (BP) guideline recommends using 10-year predicted atherosclerotic cardiovascular disease (ASCVD) risk to guide decisions to initiate antihypertensive medication. Methods: We included adults aged 40–79 (...) -- ORIGINAL ARTICLES
• 07:00
  Effect of parental arterial stiffness in offspring: the Kailuan study - Wu, Yuntao; Liu, Qian; Ma, Yihan; Han, Xu; Zhao, Xiaohong; Zhao, Haiyan; Song, Mingzhu; Sun, Junyan; Wang, Xingyu; Wu, Shouling J Hypertens
  Objective: The aim of this study was to examine effect of parental arterial stiffness in offspring. Methods: The individuals who participated in the second or subsequent follow-up and had parent-offspring relationship and completed measurements of brachial-ankle pulse wave velocity (baPWV) from (...) -- ORIGINAL ARTICLES
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  Impact of DBP on all-cause and cardiovascular mortality: results from the National Health and Nutrition Examination survey, 1999–2014 - Bae, Eunjin; Rocco, Michael V.; Lee, Jeonghwan; Park, Jae Yoon; Kim, Yong Chul; Yoo, Kyung Don; Kim, Eun Young; Park, Dong Jun; Lim, Chun Soo; Kim, Yon Su; Lee, Jung Pyo J Hypertens
  Introduction: Hypertension is common and has a significant effect on cardiovascular morbidity and death. However, despite the development of several guidelines to manage SBP, there is little research or guidance on the evaluation and management of DBP or isolated diastolic hypertension (IDH). (...) -- ORIGINAL ARTICLES
• 07:00
  Sirtuin1 contributes to the overexpression of Gi? proteins and hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats - Li, Yuan; Hossain, Ekhtear; Arifen, Nahida; Srivastava, Ashok K.; Anand-Srivastava, Madhu B. J Hypertens
  Background: We earlier demonstrated that vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) exhibit the overexpression of Gi? proteins and hyperproliferation that is attributed to the enhanced levels of endogenous angiotensin II (Ang II). In addition, the implication (...) -- ORIGINAL ARTICLES
• 07:00
  Association of proteinuria and hypertension with incident atrial fibrillation in an elderly population: nationwide data from a community-based elderly cohort - Park, Yoon Jung; Yang, Pil-Sung; Yu, Hee Tae; Kim, Tae-Hoon; Jang, Eunsun; Uhm, Jae-Sun; Pak, Hui-Nam; Lee, Moon-Hyoung; Lip, Gregory Y.H.; Joung, Boyoung J Hypertens
  Objective: The excess risk of atrial fibrillation in relation to the presence of proteinuria associated with hypertension has not been well elucidated. We aimed to determine the effect of hypertension and/or proteinuria on the incidence of atrial fibrillation. Second, we evaluated whether the (...) -- ORIGINAL ARTICLES
• 07:00
  Elevated blood pressure positively associates with alpha-1 microglobulin in prepubescent children: the ExAMIN Youth SA study - Craig, Ashleigh; Gafane-Matemane, Lebo; Smith, Wayne; Mels, Carina; Uys, Lisa; Breet, Yolandi; Brits, Sanette; Mokwatsi, Gonste; Hanssen, Henner; Kruger, Ruan J Hypertens
  Objectives and methods: Hypertension is a growing health concern in childhood populations and individuals of African descent. As the kidneys play a significant role in blood pressure regulation, we compared alpha-1 microglobulin (A1M) as a marker of proximal tubular function between young (...) -- ORIGINAL ARTICLES
• 07:00
  Blood pressure response during treadmill exercise testing and the risk for future cardiovascular events and new-onset hypertension - Zafrir, Barak; Aker, Amir; Asaf, Yosi; Saliba, Walid J Hypertens
  Objective: The physiologic response to exercise may provide valuable prognostic information. We investigated the association of blood pressure (BP) measurements during exercise stress testing (EST) with long-term risk of myocardial infarction, stroke or death (major adverse cardiovascular (...) -- ORIGINAL ARTICLES
• 07:00
  The mineralocorticoid receptor blocker spironolactone lowers plasma interferon-? and interleukin-6 in patients with type 2 diabetes and treatment-resistant hypertension - Thangaraj, Sai Sindhu; Oxlund, Christina Stolzenburg; Fonseca, Micaella Pereira Da; Svenningsen, Per; Stubbe, Jane; Palarasah, Yaseelan; Ketelhuth, Daniel F.J.; Jacobsen, Ib. Abildgaard; Jensen, Boye L. J Hypertens
  Background: The mineralocorticoid receptor antagonist spironolactone lowers blood pressure in patients with resistant hypertension despite antihypertensive treatment with angiotensin-converting inhibitors (ACEi) and angiotensin-II receptor blockers (ARB). In preclinical studies, spironolactone (...) -- ORIGINAL ARTICLES
• 07:00
  Ethnic differences and heritability of blood pressure circadian rhythm in African and European American youth and young adults - Xu, Yanyan; Su, Shaoyong; Brown, Michelle; Snieder, Harold; Harshfield, Gregory; Wang, Xiaoling J Hypertens
  Background: The aim of this study was to investigate whether blood pressure (BP) circadian rhythm in African Americans differed from that in European Americans. We further examined the genetic and/or environmental sources of variances of the BP circadian rhythm parameters and the extent to (...) -- ORIGINAL ARTICLES
• 07:00
  Fluid intake and blood pressure in children: the Salus per Aquam project - Ardissino, Gianluigi; Perrone, Michela; Ghiglia, Silvia; Salice, Patrizia; Tel, Francesca; Dardi, Elena; Bollani, Tiziana; Mezzopane, Antonella; Capone, Valentina; Ardissino, Maddalena; Vergori, Antonio; Piantanida, Sandra; Di Michele, Silvia; Tchana, Bertrand; Filippucci, Lucia; De Luca, Francesco; Consonni, Dario; Buzzetti, Roberto J Hypertens
  Background: Sodium intake is known to contribute to the development of hypertension, thus intake reduction is a cornerstone in the prevention and management of hypertension. The increase in renal sodium excretion might represent a further potential preventive and/or therapeutic opportunity. (...) -- ORIGINAL ARTICLES
• 07:00
  Central versus ambulatory blood pressure for predicting mortality and cardiovascular events in hemodialysis patients: a multicenter cohort study - Liu, Wenjin; Ye, Yinyin; Wang, Lulu; Gao, Chaoqing; Bai, Youwei; Chu, Hong; Fan, Wei; Sun, Zhuxing; Wang, Liang; Li, Xiurong; Yang, Junwei J Hypertens
  Objective: Studies in the general population suggest that central blood pressure (BP) may be superior to peripheral BP in risk assessment. Although ambulatory brachial BP is recognized as the most reliable BP measurement in the dialysis population, there is no comparison of office central BP (...) -- ORIGINAL ARTICLES
• 07:00
  Introducing the importance and difficulties of a three-step approach to improve nonadherence to antihypertensive drugs: a case series - Peeters, Laura E.J.; van der Net, Jeroen B.; Schoenmakers-Buis, Kathy; van der Meer, Irene M.; Massey, Emma K.; van Dijk, Liset; van Gelder, Teun; Koch, Birgit C.P.; Versmissen, Jorie J Hypertens
  Nonadherence to antihypertensive drugs is an important reason for not reaching blood pressure goals. A possible method to improve nonadherence involves three essential steps: identification of nonadherent patients (step 1), determination of underlying causes (step 2) and a personalized solution (...) -- CASE REPORT
• 07:00
  Inaccuracy of blood pressure measurement: the mysterious role of arterial stiffness - Papaioannou, Theodore G.; Vrachatis, Dimitrios A.; Tsioufis, Costas J Hypertens
  No abstract available -- CORRESPONDENCE
• 07:00
  Reply - Goupil, Rémi; Agharazii, Mohsen J Hypertens
  No abstract available -- CORRESPONDENCE
• 07:00
  Neuroadrenergic activation in obstructive sleep apnea syndrome: a systematic review and meta-analysis: Corrigendum J Hypertens
  No abstract available -- CORRIGENDUM

Current Opin Cardiol https://journals.lww.com/co-cardiology/

• 07:00
  Editorial introductions Current Opin Cardiol
  No abstract available -- EDITORIAL INTRODUCTIONS
• 07:00
  Mobile health technologies in the diagnosis and management of atrial fibrillation - Passman, Rod Current Opin Cardiol
  Purpose of review Atrial fibrillation is the most common sustained rhythm abnormality and is associated with stroke, heart failure, cognitive decline, and premature death. Digital health technologies using consumer-grade mobile technologies (i.e. mHealth) capable of recording heart rate and (...) -- ARRHYTHMIAS: Edited by Wilber W. Su
• 07:00
  Exclusion of left atrial appendage: effects beyond thromboembolic prevention - Bai, Rong; Zawaneh, Michael; Weiss, Peter J.; Su, Wilber W. Current Opin Cardiol
  Purpose of review This review aims to summarize the nonthromboembolic prevention effects of left atrial appendage exclusion (LAAE). Recent findings Left atrial appendage (LAA) secretes multiple hormones; regulates blood volume and pressure; and generates trigger activities. Exclusion of the LAA (...) -- ARRHYTHMIAS: Edited by Wilber W. Su
• 07:00
  Risk factors of sudden cardiac death in hypertrophic cardiomyopathy - Hong, Ying; Su, Wilber W.; Li, Xiaoping Current Opin Cardiol
  Purpose of review Hypertrophic cardiomyopathy (HCM) is one of the leading causes of sudden cardiac death (SCD) in younger people and athletes. It is crucial to identify the risk factors for SCD in individuals with HCM. This review, based on recent systematic literature studies, will focus on (...) -- ARRHYTHMIAS: Edited by Wilber W. Su
• 07:00
  Economics and laboratory efficiency of atrial fibrillation ablation - Kowalski, Marcin; Shah, Rina; Akhrass, Philippe; Parikh, Valay Current Opin Cardiol
  Purpose of review Atrial fibrillation is a growing public health problem and is associated with an increased risk of comorbidities with enormous socioeconomic implications. This review article focuses on fiscal burden of atrial fibrillation on the healthcare system and economic value of atrial (...) -- ARRHYTHMIAS: Edited by Wilber W. Su
• 07:00
  The emerging role of cardiac contractility modulation in heart failure treatment - Chinyere, Ikeotunye R.; Balakrishnan, Mahesh; Hutchinson, Mathew D. Current Opin Cardiol
  Purpose of review Heart failure often progresses despite optimal medical and device therapies, and advanced mechanical circulatory support has limited availability and substantial associated morbidity. Cardiac contractility modulation (CCM) provides nonexcitatory stimulation to ventricular (...) -- ARRHYTHMIAS: Edited by Wilber W. Su
• 07:00
  Atypical atrial flutter: review of mechanisms, advances in mapping and ablation outcomes - Ko Ko, Nway Le; Sriramoju, Anil; Khetarpal, Banveet Kaur; Srivathsan, Komandoor Current Opin Cardiol
  Purpose of review Atrial flutter (AFL) is the second most prevalent arrhythmia after atrial fibrillation (AF). It is a macro-reentrant tachycardia that is either cavotricuspid isthmus dependent (typical) or independent (atypical). This review aims at highlighting mechanism, diagnosis and (...) -- ARRHYTHMIAS: Edited by Wilber W. Su
• 07:00
  Ablation of intra-atrial reentrant tachycardias in adults with congenital heart disease: islands, isthmuses, channels, and walls - Taranto, Lydia M.; Rhee, Edward K. Current Opin Cardiol
  Purpose of review The adult congenital heart patient population is rapidly growing due to increasing survival rates, and they often face chronic physiologic challenges as sequalae of both their defects and repairs. Among the most common sequalae are arrhythmias. Here we describe intra-atrial (...) -- ARRHYTHMIAS: Edited by Wilber W. Su
• 07:00
  Posterior left atrial epicardial adipose tissue: scope of the problem and impact of new technology - Sperling, Jason S.; Delurgio, David L.; Svinarich, John Thomas Current Opin Cardiol
  Purpose of review Patients with persistent forms of atrial fibrillation are seeking treatments based on the promise of better restoration of sinus rhythm with newer therapies. Successful catheter ablation and maintenance of atrial fibrillation in this subgroup is negatively impacted by the (...) -- ARRHYTHMIAS: Edited by Wilber W. Su
• 07:00
  A tale of two balloons: technical and procedural difference between cryoballoon systems - Tomaiko-Clark, Emrie; Bai, Rong; Khokhar, Mateen; Su, Wilber W. Current Opin Cardiol
  Purpose of review The cryoballoon catheter has been an option for the treatment of atrial fibrillation for over a decade. The most widely used device is the Medtronic Arctic Advance cryoballoon catheter. Recently, Boston Scientific has released the POLARx cryoballoon catheter. Here we review (...) -- ARRHYTHMIAS: Edited by Wilber W. Su
• 07:00
  Cryoballoon atrial fibrillation ablation experience in Japan - Miyazaki, Shinsuke Current Opin Cardiol
  Purpose of review In Japan, cryoballoon ablation has been widely accepted and more than 70 000 patients have undergone pulmonary vein isolation using this novel technology since the introduction. This review focused on the current status of cryoballoon ablation in Japan and clarified the (...) -- ARRHYTHMIAS: Edited by Wilber W. Su
• 07:00
  Current evidence on the safety and efficacy of combined atrial fibrillation ablation and left atrial appendage closure - Mo, Bin-Feng; Lian, Xiao-Ming; Li, Yi-Gang Current Opin Cardiol
  Purpose of review Combined atrial fibrillation (AF) ablation and left atrial (LA) appendage (LAA) closure (LAAC) has been practiced for management of both the symptoms and the high stroke risk of AF. The purpose of this review is to review recent evidence regarding the combined procedure. (...) -- ARRHYTHMIAS: Edited by Wilber W. Su
• 07:00
  Brugada syndrome – minimizing overdiagnosis and over treatment in children - Corcia, M. Cecilia Gonzalez Current Opin Cardiol
  Purpose of review Is to summarise the new contributions toward the understanding of the broad spectrum of manifestations of Brugada syndrome (BrS) during the first years of life. The review encompasses the screening of the asymptomatic patient referred due to family history in one extreme of (...) -- PEDIATRICS: Edited by Mitchell I. Cohen
• 07:00
  The impact of socioeconomic status and race on the outcomes of congenital heart disease - Nashed, Lydia M.; O’Neil, Jennifer Current Opin Cardiol
  Purpose of review Studying the outcomes of congenital heart disease and their associations allows paediatric cardiologists and intensivists to improve the care and health equity of their patients. This review presents the most recent literature discussing the socioeconomic and racial (...) -- PEDIATRICS: Edited by Mitchell I. Cohen
• 07:00
  Every child with congenital heart disease should be exercising - Hansen, Katherine; Tierney, Seda Current Opin Cardiol
  Purpose of review Historically, children with congenital heart disease have been restricted from exercise, contributing to a sedentary lifestyle as well as increased cardiovascular risk factors. Given the large benefits and small risks of exercise in this population, guidelines have recently (...) -- PEDIATRICS: Edited by Mitchell I. Cohen
• 07:00
  Arrhythmogenic right ventricular cardiomyopathy in the pediatric population - Cohen, Mitchell I.; Atkins, Melany B. Current Opin Cardiol
  Purpose of review Review the current state of the art of arrhythmogenic right ventricular cardiomyopathy (ARVC) diagnosis and risk stratification in the pediatric population. Recent findings ARVC is an inherited cardiomyopathy characterized by progressive myocyte loss and fibrofatty replacement (...) -- PEDIATRICS: Edited by Mitchell I. Cohen
• 07:00
  When is enough, enough? Exploring ethical and team considerations in paediatric cardiac care dilemmas - Lynch, Aine; Kirsch, Roxanne Current Opin Cardiol
  Purpose of review Therapies for paediatric congenital and acquired heart disease continue to evolve and the appropriateness of pursuing life sustaining interventions at margins of standard therapy is ethically challenging. Recent findings With ongoing emphasis on shared decision making, recent (...) -- PEDIATRICS: Edited by Mitchell I. Cohen
• 07:00
  Challenges in diagnosis and management of coarctation of the aorta - Chetan, Devin; Mertens, Luc L. Current Opin Cardiol
  Purpose of review Coarctation of the aorta remains a controversial topic with uncertainties in long-term outcomes. Recent findings Recent advances in fetal imaging including echocardiography and MRI offer novel opportunities for better detection and prediction of the need for neonatal (...) -- PEDIATRICS: Edited by Mitchell I. Cohen
• 07:00
  The systemic right ventricle in adult congenital heart disease: why is it still such a challenge and is there any hope on the horizon? - Lluri, Gentian; Aboulhosn, Jamil Current Opin Cardiol
  Purpose of review Adult congenital heart disease patients with systemic right ventricle comprise a distinctly clinically challenging group of patients with increased morbidity and mortality. This article aims to review the different subgroups, most common complications and different treatment (...) -- PEDIATRICS: Edited by Mitchell I. Cohen
• 07:00
  Artificial intelligence in pediatric cardiology: taking baby steps in the big world of data - Van den Eynde, Jef; Kutty, Shelby; Danford, David A.; Manlhiot, Cedric Current Opin Cardiol
  Purpose of review Artificial intelligence (AI) has changed virtually every aspect of modern life, and medicine is no exception. Pediatric cardiology is both a perceptual and a cognitive subspecialty that involves complex decision-making, so AI is a particularly attractive tool for this medical (...) -- PEDIATRICS: Edited by Mitchell I. Cohen
• 07:00
  Regionalization of congenital cardiac surgical care: what it will take - Ghandour, Hiba Z.; Vervoort, Dominique; Welke, Karl F.; Karamlou, Tara Current Opin Cardiol
  Purpose of review Decentralized, inconsistent healthcare delivery results in variable outcomes and wastes nearly one trillion dollars annually in the United States (US). Congenital heart surgery (CHS) is not immune due to high, variable costs and inconsistent outcomes across hospitals. Many (...) -- PEDIATRICS: Edited by Mitchell I. Cohen

8 December

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Nephron overload as a therapeutic target to maximize kidney lifespan - Valerie A. Luyckx, Andrew D. Rule, Katherine R. Tuttle, Pierre Delanaye, Helen Liapis, Afschin Gandjour, Paola Romagnani, Hans-Joachim Anders Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 08 December 2021; doi:10.1038/s41581-021-00510-7This Review examines the concept of kidney lifespan and how increases in haemodynamic and metabolic demands in the kidney can lead to nephron overload, which is a common feature of progressive kidney (...) (Nature Reviews Nephrology, Published online: 2021-12-08; | doi:10.1038/s41581-021-00510-7)