28 January

Lancet https://www.thelancet.com/journals/lancet

• 00:00
  [Editorial] The NHS is sick, but it is treatable - The Lancet Lancet
  The NHS is 75 years old and is unwell. Patients with a suspected heart attack are waiting five times longer for an ambulance than the 18-min target. In 2022, 347 707 patients spent more than 12 h in Accident and Emergency departments waiting for a bed, four times as many as in the previous 10 (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Comment] Gaining MOMENTUM against anaemic myelofibrosis - Kazuhiko Ikeda, Koki Ueda Lancet
  Myelofibrosis is a progressive chronic myeloproliferative neoplasm driven by Janus kinase and signal transducer and activator of transcription (JAK–STAT) pathway activation, mostly due to mutations in JAK2, MPL, and CALR.1 Myelofibrosis arises de novo (primary myelofibrosis) or secondarily from (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Comment] Developing a vaccine against Marburg virus disease - Daniela Manno Lancet
  Marburg virus disease is a severe infection in people and non-human primates (NHPs), with a case-fatality rate of 23–90%.1 The disease is caused by the Marburg virus, a member of the Filoviridae family, which includes the viruses responsible for Ebola virus disease.1 Marburg virus disease is (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Comment] Offline: America—a codicil - Richard Horton Lancet
  Yes, the US will remain a dominant force in global health for the foreseeable future. But Shannon K O’Neil, in her provocative book The Globalization Myth, casts doubt on the sustainability of America's influence. First, the positive. The US is wealthy and has vastly skilled human resources to (...) (The Lancet 401, 10373 (2023))
• 00:00
  [World Report] New legislation to overhaul mental health care in Nigeria - Paul Adepoju Lancet
  A new mental health law is hoped to transform care for patients in Nigeria. Paul Adepoju reports from Ibadan, Nigeria. (The Lancet 401, 10373 (2023))
• 00:00
  [World Report] Mexico bans smoking in public - Sharmila Devi Lancet
  New legislation to curb the harms of tobacco is among the strongest in the world. Sharmila Devi reports. (The Lancet 401, 10373 (2023))
• 00:00
  [World Report] “Unfettered flow”: how ProMED-mail keeps the world alert - Talha Burki Lancet
  For almost 30 years, contributors to ProMED-mail have flagged new and emerging infectious threats to health. Talha Burki reports. (The Lancet 401, 10373 (2023))
• 00:00
  [Perspectives] Lynette Denny: women's cancer researcher with global impact - Udani Samarasekera Lancet
  As a young child in apartheid era South Africa, Lynette Denny saw police regularly raid the quarters of her family's domestic staff to find Black people who did not have the documents they were legally required to carry to prove their identity and employment. It left Denny with “a permanent (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Perspectives] Recruitmentology and the politics of consent in clinical research - Cameron Sabet, Simar S Bajaj, Fatima Cody Stanford Lancet
  Bearing the weight of a traumatic history, medical research is often seen as invasive and harmful by subaltern communities. The term subaltern, originating from postcolonial theory, refers to socio-politically silenced groups that are excluded from inner circles of colonial power. Western (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Obituary] Thomas Wilson Meade - Geoff Watts Lancet
  Epidemiologist and authority on thrombogenesis and heart disease. He was born in Oxford, UK, on Jan 21, 1936 and died of a lower respiratory tract infection in London, UK, on Oct 24, 2022 aged 86 years. (The Lancet 401, 10373 (2023))
• 00:00
  [Correspondence] Improving childhood cancer care in China - Yaping Wang, Jue Liu Lancet
  We read with interest Xin Ni and colleagues'1 study on cancer incidence, and the association between incidence and inaccessibility of health services among children and adolescents in China. The authors found that an estimated 121 145 cancer cases were diagnosed among children and adolescents (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Correspondence] Improving childhood cancer care in China – Authors' reply - Xin Ni, Zhe Li, Yingying Liu, Guoliang Bai, Xinping Li, Xiao Zhang Lancet
  We thank Yaping Wang and Jue Liu for their Correspondence in response to our Article1 about socioeconomic inequalities in cancer incidence and access to health services faced by Chinese children and adolescents. (The Lancet 401, 10373 (2023))
• 00:00
  [Correspondence] Medicine should be learned in a conducive environment - Sandro Vento Lancet
  Richard Horton argues that an academic health science system must possess societal goals and promote social cohesion and public trust.1 Indeed, medical education should help to promote better health outcomes for vulnerable populations and disadvantaged communities. However, to this end, it is (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Correspondence] Let research guide teaching in medical and public health - Arnaud Chiolero Lancet
  The pre-eminence of research over teaching in academic activity might be considered as an inheritance from the Enlightenment and, in the past few decades, from evidence-based medicine. Within this framework, teaching is secondary to research because the former is built, at least in part, on the (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Department of Error] Department of Error Lancet
  Schlaich MP, Bellet M, Weber MA, et al. Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial. Lancet 2022; 400: 1927–37—For this Article, the PRECISION investigators list has been updated. This correction (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Articles] Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis (MOMENTUM): results from an international, double-blind, randomised, controlled, phase 3 study - Srdan Verstovsek, Aaron T Gerds, Alessandro M Vannucchi, Haifa Kathrin Al-Ali, David Lavie, Andrew T Kuykendall, Sebastian Grosicki, Alessandra Iurlo, Yeow Tee Goh, Mihaela C Lazaroiu, Miklos Egyed, Maria Laura Fox, Donal McLornan, Andrew Perkins, Sung-Soo Yoon, Vikas Gupta, Jean-Jacques Kiladjian, Nikki Granacher, Sung-Eun Lee, Luminita Ocroteala, Francesco Passamonti, Claire N Harrison, Barbara J Klencke, Sunhee Ro, Rafe Donahue, Jun Kawashima, Ruben Mesa, on behalf of MOMENTUM Study (...) Lancet
  Treatment with momelotinib, compared with danazol, resulted in clinically significant improvements in myelofibrosis-associated symptoms, anaemia measures, and spleen response, with favourable safety. These findings support the future use of momelotinib as an effective treatment in patients with (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Articles] Safety, tolerability, and immunogenicity of the chimpanzee adenovirus type 3-vectored Marburg virus (cAd3-Marburg) vaccine in healthy adults in the USA: a first-in-human, phase 1, open-label, dose-escalation trial - Melinda J Hamer, Katherine V Houser, Amelia R Hofstetter, Ana M Ortega-Villa, Christine Lee, Anne Preston, Brooke Augustine, Charla Andrews, Galina V Yamshchikov, Somia Hickman, Steven Schech, Jack N Hutter, Paul T Scott, Paige E Waterman, Mihret F Amare, Victoria Kioko, Casey Storme, Kayvon Modjarrad, Melanie D McCauley, Merlin L Robb, Martin R Gaudinski, Ingelise J Gordon, LaSonji A Holman, Alicia T Widge, Larisa Strom, Myra Happe, Josephine H Cox, Sandra Vazquez, Daphne A Stanley, Tamar Murray, Caitlyn N M Dulan, Ruth Hunegnaw, Sandeep R Narpala, Phillip A Swanson, Manjula Basappa, (...) Lancet
  This first-in-human trial of this cAd3-Marburg vaccine showed the agent is safe and immunogenic, with a safety profile similar to previously tested cAd3-vectored filovirus vaccines. 95% of participants produced a glycoprotein-specific antibody response at 4 weeks after a single vaccination, (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Clinical Picture] An imaging pitfall: misdiagnosis of pulmonary embolism in a patient with advanced cystic fibrosis and bronchiectasis - Michal Shteinberg, Sameer Kassem, Yochai Adir, Galit Livnat, Natalia Goldberg Lancet
  A 37-year-old woman presented to our emergency room reporting chest pain and palpitations which had woken her up in the early hours of the morning. She was known to be homozygous for a rare and severe form of cystic fibrosis with a mutation, described among Jewish people of Georgian descent, in (...) (The Lancet 401, 10373 (2023))

27 January

Br Med J (BMJ) http://www.bmj.com/

• 20:06
  When I use a word . . . . The Lelamour Herbal - Jeffrey K Aronson Br Med J (BMJ)
  Herbs and herbals“A plant of which the stem does not become woody and persistent (as in a shrub or a tree), but remains more or less soft and succulent, and dies down to the ground (or entirely) after flowering.” That is the first definition of the word “herb,” given in the Oxford English (...)
• 17:56
  A bill before parliament for the right to breath clean air - Elaine Mulcahy Br Med J (BMJ)
  In August last year, the United Nations General Assembly declared that everyone on the planet has a right to a healthy environment, including clean air, water and a stable climate.1 A new bill before the UK parliament—the Clean Air (Human Rights) Bill—now sets to force the government to take (...)
• 17:16
  “Functional disorders”: one of medicine’s biggest failures - Richard Smith Br Med J (BMJ)
  About a third of patients attending neurological and gastrointestinal, or almost every outpatient clinic—have functional disorders, meaning that they do not have a physical cause that can be detected with a microscope, scanners, or blood or genetic tests. These are patients whom medicine has (...)
• 16:36
  Medical academic workforce is under threat without urgent action on pay and pensions, say peers - Jacqui Wise Br Med J (BMJ)
  Clinical research is “on a precipice” unless the government takes urgent action, peers have warned.The Lords science and technology committee said that the UK faces a severe shortage of doctors who work both in the NHS and at universities. This threatens both medical research and teaching. They (...)
• 15:26
  Maternity care: Entonox is withdrawn from some hospitals because of risk to staff from high exposure - Jacqui Wise Br Med J (BMJ)
  The Princess Alexandra Hospital in Harlow, Essex is the latest to suspend the use of Entonox in its maternity unit after air quality tests found levels of nitrous oxide that may put midwives and other healthcare workers at potential risk of harm.The Health and Safety Executive is already (...) -- Obstetrics and gynaecology
• 14:11
  Government has wasted pound15bn on unused PPE and other pandemic purchases - Ingrid Torjesen Br Med J (BMJ)
  Over the past two years the Department of Health and Social Care (DHSC) has spent £14.9bn on unused personal protective equipment (PPE) and other covid-19 pandemic items such as vaccines and drugs. The cost of ongoing storage and disposal of excess purchases and unusable PPE is likely to hit (...) -- COVID-19
• 14:06
  Covid-19: JCVI recommends autumn vaccine booster for the most vulnerable - Elisabeth Mahase Br Med J (BMJ)
  The UK should roll out a covid-19 booster vaccine in autumn 2023 for those at higher risk of severe illness, the Joint Committee on Vaccination and Immunisation (JCVI) has said.In its recommendations to the government, the committee said that smaller groups of people, such as those who are (...) -- COVID-19
• 12:41
  Black women in England are at greater risk of late cancer diagnosis than white women - Matthew Limb Br Med J (BMJ)
  Black women from Caribbean and African backgrounds are up to two times more likely to receive a late stage diagnosis for some cancers than white British women in England, a new analysis shows.Cancer Research UK, in a review of NHS Digital cancer data published in BMJ Open, said that the (...) -- Oncology, Epidemiologic studies, General practice / family medicine
• 11:16
  The questionable value of colorectal cancer screening - Minna Johansson Br Med J (BMJ)
  Screening for colorectal cancer is widespread in high income countries and strongly recommended by most guidelines.123 Evidence from randomised trials shows that invitation to screening with sigmoidoscopy or guaiac faecal occult blood test reduces colorectal cancer deaths,4 but evidence (...)