21 August

Diabetes https://diabetes.diabetesjournals.org

• 02:00
  The Yin and Yang of Modulating ?-Cell DNA Damage Response and Functional Mass Diabetes
  Pancreatic ?-cells secrete the hormone insulin, which is essential to maintain systemic glucose homeostasis. ?-Cell insufficiency due to impaired function, loss of identity, and increased cell death is central to the pathogenesis of diabetes. ?-Cells in adult life are postmitotic, with a limited (...)
• 02:00
  The ?-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events? Diabetes
  Recent reports have revived interest in the active role that ?-cells may play in type 1 diabetes pathogenesis at different stages of disease. In some studies, investigators suggested an initiating role and proposed that type 1 diabetes may be primarily a disease of ?-cells and only secondarily a (...)
• 02:00
  Going With the Flow: Pericyte-Regulated Islet Blood Flow Influences Glucose Homeostasis Diabetes
  Understanding how insulin secretion is regulated and how the ?-cells and islets become dysfunctional is critical to understanding and treating diabetes. The islets of Langerhans are highly vascularized, receiving ?10–20% of the pancreas blood flow (as measured by microbead accumulation) despite (...)
• 02:00
  The Mechanism for Adipose Endotrophin Production Diabetes
  The extracellular matrix (ECM) not only provides a structural support network for the assembly of individual cells into tissues but also affects growth, recruitment, differentiation, and function of the composing cells. In obesity, adipose tissue ECM undergoes remodeling, with dramatic changes (...)
• 02:00
  Metabolomic Markers in Early Pregnancy for Gestational Diabetes Mellitus Diabetes
  Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications, affecting 2–22% of all pregnancies depending on diagnostic criteria and study populations (1). GDM reflects an increased risk of type 2 diabetes (T2D) and cardiovascular diseases after the index pregnancy in (...)
• 02:00
  In This Issue of Diabetes Diabetes
• 02:00
  Issues and Events Diabetes
• 02:00
  A Special Thanks to Lyn Reynolds, Director of the ADA Editorial Office, as She Embarks on Her Retirement Diabetes
  For the past 26 years, the American Diabetes Association and its professional constituents have had the great pleasure of working with Lynda (“Lyn”) Reynolds, the director of the ADA Editorial Office. Lyn first joined ADA’s publishing team in 1997, when she was hired by editor in chief Charles M. (...)
• 02:00
  Erratum. Hepatic CPT1A Facilitates Liver–Adipose Cross Talk via Induction of FGF21 in Mice. Diabetes 2022;71:31–42 Diabetes
  In Fig. 3B of article cited above, for images of iWAT and eWAT, the labels “WT” and “LKO” were inadvertently transposed. LKO (Cpt1a knockout) should have been the label for the first set of images of adipose tissue, and WT (wild type) should have been the label for the second set of (...)
• 02:00
  Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes Diabetes
  Thymic presentation of self-antigens is critical for establishing a functional yet self-tolerant T-cell population. Hybrid peptides formed through transpeptidation within pancreatic ?-cell lysosomes have been proposed as a new class of autoantigens in type 1 diabetes (T1D). While the production (...)
• 02:00
  Infant Mesenchymal Stem Cell Insulin Action Is Associated With Maternal Plasma Free Fatty Acids, Independent of Obesity Status: The Healthy Start Study Diabetes
  Preclinical rodent and nonhuman primate models investigating maternal obesity have highlighted the importance of the intrauterine environment in the development of insulin resistance in offspring; however, it remains unclear if these findings can be translated to humans. To investigate possible (...)
• 02:00
  The Effect of Glucagon on Protein Catabolism During Insulin Deficiency: Exchange of Amino Acids Across Skeletal Muscle and the Splanchnic Bed Diabetes
  Transient insulin deprivation with concurrent hyperglucagonemia is a catabolic state that can occur in type 1 diabetes. To evaluate glucagon’s catabolic effect in the setting of its glucogenic effect, we measured the regional exchanges of amino acid metabolites (amino-metabolites) across muscle (...)
• 02:00
  Causal Graph Among Serum Lipids and Glycemic Traits: A Mendelian Randomization Study Diabetes
  We systematically investigated the bidirectional causality among HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TGs), fasting insulin (FI), and glycated hemoglobin A1c (HbA1c) based on genome-wide association summary statistics of Europeans (n = 1,320,016 for lipids, 151,013 (...)
• 02:00
  New Evidence of Central Nervous System Damage in Diabetes: Impairment of Fine Visual Discrimination Diabetes
  Diabetes can damage both the peripheral sensory organs, causing retinopathy, and the central visual system, leading to contrast sensitivity and impaired color vision in patients without retinopathy. Orientation discrimination is important for shape recognition by the visual system. Our (...)
• 02:00
  The p66 Shc Protein Mediates Insulin Resistance and Secretory Dysfunction in Pancreatic ?-Cells Under Lipotoxic Conditions Diabetes
  We evaluated the role of the p66Shc redox adaptor protein in pancreatic ?-cell insulin resistance that develops under lipotoxic conditions and with excess body fat. Prolonged exposure to palmitate in vitro or the presence of overweight/obesity augmented p66Shc expression levels and caused an (...)
• 02:00
  Diabetic Neuropathy in Hands: An Endemic Complication Waiting to Unfold? Diabetes
  In this cross-sectional study we aimed to quantify the somatosensory dysfunction in the hand in people with diabetes with distal symmetrical polyneuropathy (DSPN) in hands and explore early signs of nerve dysfunction in people with diabetes without DSPN in hands. The clinical diagnosis of DSPN (...)
• 02:00
  Targeting Pancreatic Islet NLRP3 Improves Islet Graft Revascularization Diabetes
  Hypoxia-induced islet cell death, caused by an insufficient revascularization of the grafts, is a major obstacle for successful pancreatic islet transplantation. Recently, it has been reported that the nucleotide-binding oligomerization domain–like receptor protein 3 (NLRP3) inflammasome is (...)
• 02:00
  Pericyte Control of Blood Flow in Intraocular Islet Grafts Impacts Glucose Homeostasis in Mice Diabetes
  The pancreatic islet depends on blood supply to efficiently sense plasma glucose levels and deliver insulin and glucagon into the circulation. Long believed to be passive conduits of nutrients and hormones, islet capillaries were recently found to be densely covered with contractile pericytes (...)
• 02:00
  Vertical Sleeve Gastrectomy Lowers SGLT2/ Slc5a2 Expression in the Mouse Kidney Diabetes
  Bariatric surgery improves glucose homeostasis, but the underlying mechanisms are not fully elucidated. Here, we show that the expression of sodium–glucose cotransporter 2 (SGLT2/Slc5a2) is reduced in the kidney of lean and obese mice following vertical sleeve gastrectomy (VSG). Indicating an (...)
• 02:00
  Acceptance of Murine Islet Allografts Without Immunosuppression in Inguinal Subcutaneous White Adipose Tissue Pretreated With bFGF Diabetes
  Prevention of immune rejection without immunosuppression is the ultimate goal of transplant immunobiology. One way to achieve this in cellular transplantation, such as with islet transplantation, is to create a favorable local environment at the transplant site. In the current study, we found (...)
• 02:00
  Roflumilast-Mediated Phosphodiesterase 4D Inhibition Reverses Diabetes-Associated Cardiac Dysfunction and Remodeling: Effects Beyond Glucose Lowering Diabetes
  Patients with type 2 diabetes have a substantial risk of developing cardiovascular disease. Phosphodiesterase 4 (PDE4) dysregulation is of pathophysiological importance in metabolic disorders. For determination of the role of PDE4 in diabetic cardiac dysfunction, mice fed with a high-fat diet (...)
• 02:00
  The Transcription Factor YY1 Is Essential for Normal DNA Repair and Cell Cycle in Human and Mouse ?-Cells Diabetes
  Identifying the mechanisms behind the ?-cell adaptation to failure is important to develop strategies to manage type 2 diabetes (T2D). Using db/db mice at early stages of the disease process, we took advantage of unbiased RNA sequencing to identify genes/pathways regulated by insulin resistance (...)
• 02:00
  Plasma apoM Levels and Progression to Kidney Dysfunction in Patients With Type 1 Diabetes Diabetes
  Apolipoprotein M (apoM), primarily carried by HDL, has been associated with several conditions, including cardiovascular disease and diabetic nephropathy. This study proposes to examine whether plasma apoM levels are associated with the development of diabetic kidney disease, assessed as (...)
• 02:00
  Immunogenicity and Safety of SARS-CoV-2 mRNA Vaccines in a Cohort of Patients With Type 1 Diabetes Diabetes
  Patients with type 1 diabetes (T1D) may develop severe outcomes during coronavirus disease 2019 (COVID-19), but their ability to generate an immune response against the SARS-CoV-2 mRNA vaccines remains to be established. We evaluated the safety, immunogenicity, and glycometabolic effects of the (...)
• 02:00
  Predictive Metabolomic Markers in Early to Mid-pregnancy for Gestational Diabetes Mellitus: A Prospective Test and Validation Study Diabetes
  Gestational diabetes mellitus (GDM) predisposes pregnant individuals to perinatal complications and long-term diabetes and cardiovascular diseases. We developed and validated metabolomic markers for GDM in a prospective test-validation study. In a case-control sample within the PETALS cohort (...)
• 02:00
  MicroRNA-29 Ameliorates Fibro-Inflammation and Insulin Resistance in HIF1?-Deficient Obese Adipose Tissue by Inhibiting Endotrophin Generation Diabetes
  Dysregulation of extracellular matrix proteins in obese adipose tissue (AT) induces systemic insulin resistance. The metabolic roles of type VI collagen and its cleavage peptide endotrophin in obese AT are well established. However, the mechanisms regulating endotrophin generation remain (...)