1 November

Kidney Int http://www.kidney-international.org/

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  Table of Contents Kidney Int
  (Kidney International 100, 5 (2021))
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  Subscription Information Kidney Int
  (Kidney International 100, 5 (2021))
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  Editorial Board Kidney Int
  (Kidney International 100, 5 (2021))
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  In this issue Kidney Int
  Nephronophthisis (NPH) is a hereditary ciliopathy and an important cause of end-stage kidney disease. Homozygous deletion of the NPHP1 gene is the most common cause of NPH. The protein product of NPHP1 is nephrocystin 1, and in addition to the kidney, it is found in the photoreceptors of the (...) (Kidney International 100, 5 (2021))
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  Journal Club Kidney Int
  Son et al. ([e-pub ahead of print] J Clin Invest. https://doi.org/10.1172/JCI146771. Accessed September 8, 2021.) (Kidney International 100, 5 (2021))
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  Telomere length and chronic kidney disease: cause or consequence? - Florian Kronenberg Kidney Int
  Telomere length is considered as a clock mirroring aging and is influenced by oxidative stress and inflammation. Both conditions are highly prevalent in patients with chronic kidney disease and other degenerative disorders, such as cardiovascular disease. However, it is discussed (...) (Kidney International 100, 5 (2021))
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  Urinary Dickkopf-3 and kidney injury in patients with chronic pulmonary disease - Stefanie Thöni, Gert Mayer Kidney Int
  Dickkopf-related protein 3 is a stress-induced, epithelial cell–derived glycoprotein that is promoted as a prognostic as well as a predictive urinary biomarker in acute and chronic kidney disease. Schunk et al. provided evidence that Dickkopf-related protein 3 identifies patients with chronic (...) (Kidney International 100, 5 (2021))
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  Jury still out on whether FGF23 is a direct contributor, a useful biomarker, or neither - Hirotaka Komaba, Masafumi Fukagawa Kidney Int
  Fibroblast growth factor 23 (FGF23) is an endocrine hormone that is mainly produced by osteocytes. In patients with chronic kidney disease (CKD), circulating FGF23 levels increase as kidney function declines. This helps maintain normal phosphate balance by enhancing urinary phosphate excretion. (...) (Kidney International 100, 5 (2021))
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  Role of FGF23 in clinical outcomes of patients with chronic kidney disease - Tilman B. Drüeke Kidney Int
  Mutations and overexpression of the hormone fibroblast growth factor 23 (FGF23) were discovered 20 years ago as the cause of autosomal dominant hypophosphatemic rickets and tumor-induced osteomalacia, respectively. Subsequently, numerous studies first demonstrated the role of FGF23 in (...) (Kidney International 100, 5 (2021))
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  Fibroblast growth factor 23, the time is right for a second wind - Marc Vervloet Kidney Int
  Like many novel discoveries, the recognition of a clinically relevant role of fibroblast growth factor 23 (FGF23) in nephrology was welcomed with almost untamed enthusiasm. Indeed, initial findings were stunning on several levels. First, the rise of circulating FGF23, as chronic kidney disease (...) (Kidney International 100, 5 (2021))
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  The authors reply: - Junjiong Zheng, Hao Yu, Zhuo Wu, Xiaoguang Zou, Tianxin Lin Kidney Int
  We thank Zhang et al.1 for their interest in our study.2 Usually, feature reproducibility assessment is implemented for data dimension reduction. However, because the margins of a urinary stone in computed tomography images are clear, satisfactory interobserver feature extraction (...) (Kidney International 100, 5 (2021))
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  A machine learning–based radiomic model for predicting urinary infection stone - Lu Zhang, Bin Zhang Kidney Int
  We read with great interest the article by Zheng et al.,1 published in Kidney International. This study leveraged a noninvasive radiomic model to preoperatively predict infection stones. Despite the encouraging results, several methodological issues should be noted. A robust radiomic biomarker (...) (Kidney International 100, 5 (2021))
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  Gains in understanding of podocyte loss - Agnes B. Fogo Kidney Int
  Podocyte loss is a key element underlying glomerulosclerosis. Various mechanisms have been proposed for cell loss. These include local hemodynamic effects and local stresses on cell and hemodynamic changes, which together may contribute to detachment of podocytes, leading to sclerosis. Elegant (...) (Kidney International 100, 5 (2021))
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  Ketone bodies: back to a place in the sun - Shinji Kume Kidney Int
  Ketone bodies have a strong negative image in medicine because of ketoacidosis, a life-threatening complication in diabetes. However, Fang et al. report that ketone bodies exert antisenescent effects in podocytes under diabetic conditions, via activation of the nuclear factor E2-related factor (...) (Kidney International 100, 5 (2021))
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  Point-of-care Doppler ultrasonography: a new dimension to kidney imaging - Abhilash Koratala, Amir Kazory Kidney Int
  We read with great interest the article by Caroli et al., in which they meticulously discuss the role of imaging in elucidating both structural and functional aspects of kidney disease.1 Herein, we would like to briefly comment on evaluation of renal venous congestion in clinical practice. (...) (Kidney International 100, 5 (2021))
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  The Case | Unexplained inflammation after treatment for granulomatosis with polyangiitis - Heidy Hendra, Viyaasan Mahalingasivam, Alan D. Salama, Aine Burns Kidney Int
  A 64-year-old man with granulomatosis with polyangiitis (GPA) reported feeling “below par.” Almost 2 years earlier, he had presented with nasal crusting, epistaxis, deafness, weight loss, night sweats, and nonvisible hematuria. No baseline imaging was performed. Cytoplasmic anti-neutrophil (...) (Kidney International 100, 5 (2021))
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  Ultrasound findings of calciphylaxis - Raphael J. Rosen, Hilda E. Fernandez, Shayan Shirazian, Andrew A. Moses Kidney Int
  A 67-year-old woman with end-stage kidney disease on peritoneal dialysis, with diabetes, with atrial fibrillation treated with warfarin, and with Sjogren syndrome presented with firm subcutaneous nodules on her thighs and a large exquisitely tender erythematous lesion on her abdomen with a (...) (Kidney International 100, 5 (2021))
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  Unilateral nephrocalcinosis - Aghilès Hamroun, Frederic Brioude, Arnaud Lionet Kidney Int
  A 37-year-old man with unremarkable medical history was referred to our nephrology department for unilateral left nephrocalcinosis, incidentally discovered on imaging for chronic low back pain (Figure 1, arrow). On clinical examination, we were struck by a lateralized overgrowth of the left (...) (Kidney International 100, 5 (2021))
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  Acute renal cortical necrosis: cortical rim sign and reverse rim sign - Chandra Bhushan Prasad, Rakavi Rathinasamy, Chirag Rajkumar Kopp, Siddharth Jain, Sanjay Jain, Varun Dhir Kidney Int
  A 35-year-old primigravida, with an uneventful antenatal course, presented with anuria and high-grade fever for 4 days after an emergency caesarean section at 37 weeks, done because of oligohydramnios and fetal distress. On presentation, she was febrile and had anasarca and basal crepitations (...) (Kidney International 100, 5 (2021))

27 October

Kidney Int http://www.kidney-international.org/

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  Untangling the fibers of sarcopenia: activin A in CKD-associated muscle wasting - Andrew S. Terker, T. Alp Ikizler Kidney Int
  Solagna F, Tezze C, Lindenmeyer MT, et al. Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs. J Clin Invest 2021;131. (Kidney International (2021))