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(Kidney International 101, 6 (2022))
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In this issue of Kidney International, we are pleased to introduce a new article series called Next Generation Clinical Pathologic Conference (CPC). These articles will merge the traditional CPC with molecular medicine for a fresh approach to decipher mechanisms of kidney disease. In (...) (Kidney International 101, 6 (2022))
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Rurik et al. (Science. 2022;375:91–96.) (Kidney International 101, 6 (2022))
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Calcimimetics allosterically increase the calcium ion sensitivity of the calcium-sensing receptor (CaSR). Using a CaSR knockdown in podocytes and a podocyte-specific CaSR knockout in mice, Mühlig et al. uncovered a stabilizing role for actin cytoskeleton and cell adhesion. Short-term alleviation (...) (Kidney International 101, 6 (2022))
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Growth differentiation factor 15 is a potential renoprotective factor whose expression is induced primarily at the proximal tubular site after kidney injury. Valiño-Rivas et al. confirmed the protective effect of growth differentiation factor 15 against different types of kidney injury and (...) (Kidney International 101, 6 (2022))
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We thank Subbiah and Bhowmik1 for their comments. They point out that the Kidney Disease: Improving Global Outcomes recommendation2 focuses on the chronic kidney disease (CKD) subgroup of Systolic Blood Pressure Intervention Trial (SPRINT). That is because it is the best available evidence for (...) (Kidney International 101, 6 (2022))
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The “KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease” recommends a systolic blood pressure (BP) target (Kidney International 101, 6 (2022))
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The above-stated article contained an incorrect version of Figure 3 in which the representative micrograph of senescence-associated beta-galactosidase (SA-?-gal) staining in the ?-hydroxybutyrate (?-HB) group in Figure 3a was inadvertently used from the results of a different experiment (...) (Kidney International 101, 6 (2022))
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There are 3 corrections for the above-stated article. (Kidney International 101, 6 (2022))
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A new inflammatory disease characterized by somatic X-linked mutation of the UBA1 gene has been recently described in males and named “VEXAS syndrome,” an acronym for “Vacuoles, E1 enzyme, X linked, Autoinflammatory, Somatic syndrome.”1 Despite the fact that it affects the kidneys in up to 10% of (...) (Kidney International 101, 6 (2022))
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Recent reports suggest that eculizumab may not only compromise MenB-4C vaccination–induced serum killing of meningococci, but also opsonophagocytic killing.1,2 Using pre- and postvaccination serum from 5 patients with atypical hemolytic uremic syndrome (aHUS) on treatment with eculizumab and 2 (...) (Kidney International 101, 6 (2022))
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We read with great interest the review article by Mejia-Vilet et al. about the management of lupus nephritis (LN).1 The authors mentioned that few uncontrolled studies had evaluated tacrolimus in combination with mycophenolate mofetil for LN.1 In a recent prospective observational study from (...) (Kidney International 101, 6 (2022))
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Hemolytic uremic syndrome can be initiated by Escherichia coli infections (Shiga-toxin–producing enterohemorrhagic Escherichia coli hemolytic uremic syndrome). When hemoglobin and heme released from ruptured erythrocytes interact with the kidney cells, this can result in platelet activation, (...) (Kidney International 101, 6 (2022))
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We appreciate Meyers for sharing a real-world perspective of caring for patients with kidney diseases in developing countries. The author also provided guidance for dealing with kidney diseases of these populations as a lower priority among other public health problems, including economic (...) (Kidney International 101, 6 (2022))
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The authors of the special report promoting World Kidney Day must be congratulated on their article dealing with “Kidney Health for All” (the International Society of Nephrology [ISN]/International Federation of Kidney Foundations [IFKF] slogan).1 This most interesting and thought-provoking (...) (Kidney International 101, 6 (2022))
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An 81-year-old woman with stage G3 chronic kidney disease status post left nephrectomy for upper tract urothelial carcinoma 20 years ago was admitted to our hospital for heart failure. She acutely developed right thigh pain, and contrast-enhanced computed tomography revealed an idiopathic (...) (Kidney International 101, 6 (2022))
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A 36-year-old woman presented to the emergency department with recurrent syncope. She was diagnosed with nephrotic syndrome 16 days previously. Since she refused a kidney biopsy, she had been empirically treated with oral prednisone. A noncontrast computed tomography scan of the brain showed a (...) (Kidney International 101, 6 (2022))
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A 56-year-old patient on home hemodialysis noticed a yellow discoloration to the effluent fluid in his dialyzer and tubing (Figure 1a) shortly after commencing dialysis. Dialysis was ceased and a dialysate sample collected. Medical history included autosomal dominant polycystic kidney disease, (...) (Kidney International 101, 6 (2022))
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A 63-year-old man with end-stage kidney disease secondary to atrophic right kidney and type 2 diabetes mellitus received a living-related kidney allograft from his sister. Induction therapy included thymoglobulin, and maintenance immunosuppression consisted of tacrolimus and mycophenolate (...) (Kidney International 101, 6 (2022))