04:05miR?193b?3p and miR?346 Exert Antihypertensive Effects in the Rostral Ventrolateral Medulla -
Shuai Zhang, Xueping Wang , Tengteng Dai , Lei Tong , Gaojun Chen , Linping Wang , Zhangyan Ren , Haisheng Liu , and Dongshu Du 1 International Cooperation Laboratory of Molecular Medicine, Academy of Chinese Medical Sciences Zhejiang Chinese Medical University Hangzhou Zhejiang China 2 College of Life Sciences Shanghai University Shanghai China 3 College of Agriculture and Bioengineering Heze University Heze Shandong China 4 Shaoxing Institute of Shanghai University Shaoxing Zhejiang China
J Am Heart Assoc
Journal of the American Heart Association, Ahead of Print. BackgroundRostral ventrolateral medulla (RVLM) neuron hyperactivity raises sympathetic outflow, causing hypertension. MicroRNAs (miRNAs) contribute to diverse biological processes, but their influence on RVLM neuronal excitability and (…) (Journal of the American Heart Association)
04:05
Journal of the American Heart Association, Ahead of Print. BackgroundExperimental preeclampsia (ePE) has been shown to have worsened outcome from stroke. We investigated the effect of low?dose aspirin, known to prevent preeclampsia, on stroke hemodynamics and outcome, and the association between (…) (Journal of the American Heart Association)
04:05Evaluating the American Heart Association/American College of Cardiology Guideline—Recommended and Contemporary Pretest Probability Models in a Mixed Asian Cohort: The Contribution of Coronary Artery Calcium -
Lohendran Baskaran, Linxuan Yan , Chun S. Tan , Woon W. Ho , Swee Y. Tan , Michelle C. Williams , Donghee Han , Rine Nakanishi , Rodrigo J. Cerci , Ming?Yen Ng , Leslee J. Shaw , Terrance S. J. Chua , Pamela Douglas , and Simon Winther 1 Department of Cardiology National Heart Centre Singapore Singapore Singapore 2 Duke?NUS Medical School National University of Singapore Singapore Singapore 3 CVS.AI National Heart Research Institute of Singapore Singapore Singapore 4 University of Edinburgh/British Heart Foundation Centre for Cardiovascular Science Edinburgh UK 5 Department of Imaging (…)
J Am Heart Assoc
Journal of the American Heart Association, Ahead of Print. BackgroundMost pretest probability (PTP) tools for obstructive coronary artery disease (CAD) were Western ?developed. The most appropriate PTP models and the contribution of coronary artery calcium score (CACS) in Asian populations (…) (Journal of the American Heart Association)
04:05Checkpoint Kinase 1 Stimulates Endogenous Cardiomyocyte Renewal and Cardiac Repair by Binding to Pyruvate Kinase Isoform M2 C?Domain and Activating Cardiac Metabolic Reprogramming in a Porcine Model of Myocardial Ischemia/Reperfusion Injury -
Tian?Wen Wei, Tian?Kai Shan , Hao Wang , Jia?Wen Chen , Tong?Tong Yang , Liu?Hua Zhou , Di Zhao , Jia?Teng Sun , Si?Bo Wang , Ling?Feng Gu , Chong Du , Qi?Qi Jiang , Rui Sun , Qi?Ming Wang , Xiang?Qing Kong , Xiao?Hu Lu , Hao?Liang Sun , Yi Xu , Li?Ping Xie , Ai?Hua Gu , Feng Chen , Yong Ji , Xue?Jiang Guo , and Lian?Sheng Wang 1 Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing China 2 Department of Cardiovascular Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China 3 Department of Radiology The First Affiliated (…)
J Am Heart Assoc
Journal of the American Heart Association, Ahead of Print. BackgroundThe regenerative capacity of the adult mammalian hearts is limited. Numerous studies have explored mechanisms of adult cardiomyocyte cell?cycle withdrawal. This translational study evaluated the effects and underlying mechanism (…) (Journal of the American Heart Association)
04:05
Journal of the American Heart Association, Ahead of Print. BackgroundThe study aimed to describe the patterns and trends of initiation, discontinuation, and adherence of oral anticoagulation (OAC) in patients with new?onset postoperative atrial fibrillation (POAF), and compare with patients (…) (Journal of the American Heart Association)
04:05Sex Disparities in Resuscitation Quality Following Out of Hospital Cardiac Arrest -
Belinda Delardes, Jenna Schwarz , Tara Ralph , David Anderson , Emily Nehme , and Ziad Nehme 1 Center for Research and Evaluation, Ambulance Victoria Blackburn North Victoria Australia 2 Department of Paramedicine Monash University Frankston Victoria Australia 3 School of Public Health and Preventive Medicine Monash University St. Kilda Victoria Australia 4 Department of Intensive Care and Hyperbaric Medicine The Alfred Hospital Prahran Victoria Australia
J Am Heart Assoc
Journal of the American Heart Association, Ahead of Print. BackgroundWomen are known to be disadvantaged compared with men in the early links of the Chain of Survival, receiving fewer bystander interventions. We aimed to describe sex?based disparities in emergency medical service resuscitation (…) (Journal of the American Heart Association)
04:05Impact of Defibrillator Electrode Placement on Outcome of Electrical Cardioversion of Atrial Fibrillation: A Pilot Observational Study -
Luai Madanat, Josh France , Nolan Shoukri , Abhay N. Bilolikar , Daniel Walsh , Ilana Kutinsky , Sujana Gundlapalli , Lili Zhao , Anil Goel , Brian Williamson , Elvis Cami , Michael Gallagher , Richard Bloomingdale , Simon Dixon , David Haines , and Nishaki Mehta 1 Department of Cardiovascular Medicine, William Beaumont University Hospital Corewell Health East Royal Oak MI USA 2 Oakland University William Beaumont School of Medicine Rochester MI USA 3 Department of Biostatistics and Health Informatics Beaumont Research Institute Royal Oak MI USA 4 University of Virginia Charlottesville VA USA
J Am Heart Assoc
Journal of the American Heart Association, Ahead of Print. BackgroundAnterior–posterior electrode placement is preferred in electrical cardioversion of atrial fibrillation. However, the optimal anterior–posterior electrode position in relation to the heart is not studied.Methods and ResultsWe (…) (Journal of the American Heart Association)
04:04
Journal of the American Heart Association, Ahead of Print. BackgroundPostpartum hypertension is a risk factor for severe maternal morbidity; however, barriers exist for diagnosis and treatment. Remote blood pressure (BP) monitoring programs are an effective tool for monitoring BP and may (…) (Journal of the American Heart Association)
04:04Urinary Equol and Equol?Predicting Microbial Species Are Favorably Associated With Cardiometabolic Risk Markers in Chinese Adults -
Shaoxian Liang, Honghua Zhang , Yufeng Mo , Yamin Li , Xiaoyu Zhang , Hongjuan Cao , Shaoyu Xie , Danni Wang , Yaning Lv , Yaqin Wu , Zhuang Zhang , and Wanshui Yang 1 Department of Nutrition, Center for Big Data and Population Health of IHM School of Public Health, Anhui Medical University Hefei Anhui China 2 Key Laboratory of Population Health Across Life Cycle (Anhui Medical University) Ministry of Education of the People’s Republic of China Hefei Anhui China 3 NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract Hefei Anhui China 4 Anhui Provincial Key Laboratory of (…)
J Am Heart Assoc
Journal of the American Heart Association, Ahead of Print. BackgroundThe association between soy isoflavones intake and cardiometabolic health remains inconclusive. We investigated the associations of urinary biomarkers of isoflavones including daidzein, glycitein, genistein, equol (a gut (…) (Journal of the American Heart Association)
04:04Long?Term Visit?to?Visit Blood Pressure Variability and Cognitive Decline Among Patients With Hypertension: A Pooled Analysis of 3 National Prospective Cohorts -
Guangjun Zheng, Biying Zhou , Zhenger Fang , Xia Chen , Mingliang Liu , Fudong He , Haofeng Zhang , Haidong Zhu , Yanbin Dong , and Guang Hao 1 Department of Public Health and Preventive Medicine, School of Medicine Jinan University Guangzhou China 2 School of Public Health Guangdong Pharmaceutical University Guangzhou China 3 Georgia Prevention Institute, Department of Medicine, Medical College of Georgia Augusta University Augusta GA USA
J Am Heart Assoc
Journal of the American Heart Association, Ahead of Print. BackgroundA limited number of studies investigated the association between blood pressure variability (BPV) and cognitive impairment in patients with hypertension. This study aimed to identify the longitudinal association between BPV and (…) (Journal of the American Heart Association)
04:04P53 Activation Promotes Maturational Characteristics of Pluripotent Stem Cell?Derived Cardiomyocytes in 3?Dimensional Suspension Culture Via FOXO?FOXM1 Regulation -
Nivedhitha Velayutham, Jessica C. Garbern , Hannah L. T. Elwell , Zhu Zhuo , Laura Rüland , Farid Elcure Alvarez , Sara Frontini , Yago Rodriguez Carreras , Marie Eichholtz , Elisabeth Ricci?Blair , Jeanna Y. Shaw , Aldric H. Bouffard , Morgan Sokol , Estela Mancheño Juncosa , Seth Rhoades , Daphne van den Berg , Alexander Kreymerman , Junya Aoyama , Jens Höfflin , Herb Ryan , Shannan Ho Sui , and Richard T. Lee 1 Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute Harvard University Cambridge MA USA 2 Department of Cardiology Boston Children’s Hospital (…)
J Am Heart Assoc
Journal of the American Heart Association, Ahead of Print. BackgroundCurrent protocols generate highly pure human induced pluripotent stem cell–derived cardiomyocytes (hiPSC?CMs) in vitro that recapitulate characteristics of mature in vivo cardiomyocytes. Yet, a risk of arrhythmias exists when (…) (Journal of the American Heart Association)
04:03Addressing Disparities in Pediatric Congenital Heart Disease: A Call for Equitable Health Care -
Devyani Chowdhury, Pietro A. Elliott , S. Yukiko Asaki , Shahnawaz Amdani , Quang?Tuyen Nguyen , Christina Ronai , Seda Tierney , Victor Y. Levy , Kriti Puri , Carolyn A. Altman , Jonathan N. Johnson , and Julie S. Glickstein 1 Cardiology Care for Children Lancaster PA USA 2 Nemours Cardiac Center Wilmington DE USA 3 Department of Pediatric Cardiology University of Utah, and Primary Children’s Hospital Salt Lake UT USA 4 Division of Cardiology & Cardiovascular Medicine, Children’s Institute Department of Heart Vascular & Thoracic Cleveland OH USA 5 Division of Cardiology, Department of (…)
J Am Heart Assoc
Journal of the American Heart Association, Ahead of Print. While significant progress has been made in reducing disparities within the US health care system, notable gaps remain. This article explores existing disparities within pediatric congenital heart disease care. Congenital heart disease, (…) (Journal of the American Heart Association)
04:03Heterogeneous Effects of Intensive Glycemic and Blood Pressure on Cardiovascular Events Among Diabetes by Living Arrangements -
Kanta Kiyohara, Naoki Kondo , Taku Iwami , Yuichiro Yano , Akira Nishiyama , Koichi Node , Nobuya Inagaki , O. Kenrik Duru , and Kosuke Inoue 1 Department of Social Epidemiology Graduate School of Medicine Kyoto University Kyoto Japan 2 Department of Preventive Services Kyoto University School of Public Health Kyoto Japan 3 Noncommunicable Disease Epidemiology Research Center Shiga University of Medical Science Shiga Japan 4 Department of Pharmacology Kagawa University Medical School Kagawa Japan 5 Department of Cardiovascular Medicine Saga University Saga Japan 6 Medical Research (…)
J Am Heart Assoc
Journal of the American Heart Association, Ahead of Print. BackgroundAlthough living alone versus with others is a key social element for cardiovascular prevention in diabetes, evidence is lacking about whether the benefit of intensive glycemic and blood pressure (BP) control differs by living (…) (Journal of the American Heart Association)
04:03Abbreviated Versus Standard Dual Antiplatelet Therapy Times After Percutaneous Coronary Intervention in Patients With High Bleeding Risk With Acute Coronary Syndrome: Insights From the SWEDEHEART Registry -
Anton Håkansson, Sasha Koul , Elmir Omerovic , Jonas Andersson , Stefan James , Stefan Agewall , Arash Mokhtari , Jesper van Der Pals , Axel Wester , Karolina Szummer , Tomas Jernberg , David Erlinge , and Moman A. Mohammad 1 Department of Cardiology, Clinical Sciences Lund University, Skåne University Hospital Lund Sweden 2 Department of Cardiology Sahlgrenska University Hospital, Gothenburg University Gothenburg Sweden 3 Department of Cardiology Umeå University Umeå Sweden 4 Department of Cardiology Uppsala University Uppsala Sweden 5 Department of Clinical sciences, Danderyd Hospital (…)
J Am Heart Assoc
Journal of the American Heart Association, Ahead of Print. BackgroundDual antiplatelet therapy (DAPT) reduces ischemic events but increases bleeding risk, especially in patients with high bleeding risk (HBR). This study aimed to compare outcomes of abbreviated versus standard DAPT strategies in (…) (Journal of the American Heart Association)
04:03
Journal of the American Heart Association, Ahead of Print. BackgroundThis study assesses the diagnostic utility of strain parameters from cardiovascular magnetic resonance feature tracking across all cardiac chambers in patients with acute myocarditis, stratified by ejection fraction.Methods and (…) (Journal of the American Heart Association)
04:03
Journal of the American Heart Association, Ahead of Print. BACKGROUNDAtherosclerosis is triggered by the retention of apolipoprotein B?containing lipoproteins by proteoglycans. In addition to low?density lipoprotein, remnant lipoproteins have emerged as pivotal contributors to this pathology, (…) (Journal of the American Heart Association)
04:03
Journal of the American Heart Association, Ahead of Print. BackgroundWild?type transthyretin amyloid (ATTRwt) cardiomyopathy is increasingly recognized in the development of heart failure. The link between cardiac performance, hemodynamics, and mitochondrial function in disease stages of ATTRwt (…) (Journal of the American Heart Association)
04:02Association of Cannabis Use Disorder With Hospitalizations for Pulmonary Embolism and Subsequent in?Hospital Mortality in Young Adults: A Contemporary Nationwide Analysis -
Rupak Desai, Nitin Ghadge , Sai Gautham Kanagala , Nishanth Katukuri , Alpha James , Avinash Kadiyala , Sai Diksha Vutukuru , Meghana Kotharu , Tajdin Borzoo , Akhila Nalla , Ankit Vyas , Shivani Priyadarshni , Mostafa Shalaby , and Wissam Khalife 1 Independent Researcher Atlanta GA 2 New York State Department of Health Albany NY 3 Metropolitan Hospital Center New York NY 4 Department of Internal Medicine Mayo Clinic Rochester MN 5 Bukovinian State Medical University Chernivitsi Ukraine 6 Deccan College of Medical Sciences Hyderabad Telangana India 7 M N Raju Medical College Sangareddy (…)
J Am Heart Assoc
Journal of the American Heart Association, Ahead of Print. BackgroundWith the increase in popularity of cannabis and its use and the lack of large?scale data on cannabis use and venous thromboembolism and pulmonary embolism (PE), we used a nationally representative cohort of young adults (aged (…) (Journal of the American Heart Association)
04:02Survival and Neurologic Outcomes From Pharmacologic Peptide Administration During Cardiopulmonary Resuscitation of Pulseless Electrical Activity -
Matt T. Oberdier, Jing Li , Daniel I. Ambinder , Masahito Suzuki , Ethan Tumarkin , Sarah Fink , Luca Neri , Xiangdong Zhu , Cody N. Justice , Terry L. Vanden Hoek , and Henry R. Halperin 1 Johns Hopkins University Baltimore MD 2 University of Illinois – Chicago Chicago IL
J Am Heart Assoc
Journal of the American Heart Association, Ahead of Print. BackgroundOutcomes from cardiopulmonary resuscitation (CPR) following sudden cardiac arrest are suboptimal. Postresuscitation targeted temperature management has been shown to have benefit in subjects with sudden cardiac arrest due to (…) (Journal of the American Heart Association)
04:02Preoperative Malnutrition Increases Risk of In?Hospital Mortality, Major Infection, and Longer Intensive Care Unit Stay After Ventricular Septal Defect Closure -
Rachel E. Wittenberg, Kimberlee Gauvreau , Christopher P. Duggan , Xinwei Du , Do Giang , Kishore Jayanthi , Nestor Sandoval , Sivakumar Sivalingam , Xiaolei Zhao , and Kathy J. Jenkins 1 Harvard Medical School Boston MA USA 2 Boston Children’s Hospital Boston MA USA 3 Shanghai Children’s Medical Center Shanghai China 4 Nhi Dong 1 Ho Chi Minh City Vietnam 5 Star Hospital Hyderabad India 6 Fundación Cardioinfantil y LaCardio Bogotá Colombia 7 Institut Jantung Negara Kuala Lumpur Malaysia 8 TEDA International Cardiovascular Hospital Tianjin China
J Am Heart Assoc
Journal of the American Heart Association, Ahead of Print. BackgroundHigh energy requirements and poor feeding can lead to growth failure in patients with ventricular septal defect (VSD), but effects of preoperative malnutrition on surgical outcomes are poorly understood, especially in (…) (Journal of the American Heart Association)
04:02Impact of Weight Gain on Cardiovascular Outcomes in Patients With Atrial Fibrillation -
Aditya Bhonsale, Jianhui Zhu , Floyd Thoma , Krishna Kancharla , Andrew Voigt , Nathan A. Estes , Alaa A. Shalaby , Samir Saba , Suresh Mulukutla , and Sandeep Jain 1 Section of Cardiac Electrophysiology, Division of Cardiology University of Pittsburgh Medical Center Pittsburgh PA USA 2 Department of Cardiology University of Pittsburgh Medical Center Pittsburgh PA USA
J Am Heart Assoc
Journal of the American Heart Association, Ahead of Print. BackgroundThe long?term impact of weight gain (WG) on cardiovascular outcomes among patients with atrial fibrillation (AF) is unclear.Methods and ResultsWe studied 62 871 (mean age, 72±12, 43% women) adult patients with AF evaluated at (…) (Journal of the American Heart Association)
04:02
Journal of the American Heart Association, Ahead of Print. BackgroundThe aim of this study was to evaluate the association between early postpartum weight change and (1) hospital readmission and (2) 2?week blood pressure trajectory.Methods and ResultsThis retrospective study cohort included 1365 (…) (Journal of the American Heart Association)
04:01
Journal of the American Heart Association, Ahead of Print. BackgroundWe aimed to clarify the predictive value of cerebral small?vessel disease and intracranial large artery disease (LAD) observed in magnetic resonance imaging of the brain and magnetic resonance angiography on future vascular (…) (Journal of the American Heart Association)
04:01Qualifying Event and Recurrence of Ischemic Stroke in Symptomatic Artery Occlusion: A Post Hoc Analysis of CMOSS -
Guangdong Lu, Tao Wang , Xinyi Sun , Renjie Yang , Jichang Luo , Xiaoguang Tong , Yuxiang Gu , Jiyue Wang , Zhiyong Tong , Dong Kuai , Yiling Cai , Jun Ren , Donghai Wang , Lian Duan , Aisha Maimaitili , Chunhua Hang , Jiasheng Yu , Yan Ma , Sheng Liu , Liqun Jiao 1 Department of Neurosurgery and Interventional Neuroradiology Xuanwu Hospital, China International Neuroscience Institute, Capital Medical University, National Center for Neurological Disorders Beijing China 2 Department of Interventional Radiology The First Affiliated Hospital With Nanjing Medical University Nanjing Jiangsu (…)
J Am Heart Assoc
Journal of the American Heart Association, Ahead of Print. BackgroundThe authors aimed to elucidate the relationship between latest ischemic event and the incidence of subsequent ischemic stroke in patients with symptomatic artery occlusion.Methods and ResultsWe analyzed the association between (…) (Journal of the American Heart Association)
04:01
Journal of the American Heart Association, Ahead of Print. (Journal of the American Heart Association)