11:00
Circulation, Ahead of Print. Valvular heart disease is a common cause of morbidity and mortality worldwide and has no effective medical therapy. Severe disease is managed with valve replacement procedures, which entail high health care–related costs and postprocedural morbidity and mortality. (…) (Circulation)
11:00Novel Mouse Model of Myocardial Infarction, Plaque Rupture, and Stroke Shows Improved Survival With Myeloperoxidase Inhibition -
Sohel Shamsuzzaman Rebecca A. Deaton Anita Salamon Heather Doviak Vlad Serbulea Victoria M. Milosek Megan A. Evans Santosh Karnewar Subhi Saibaba Gabriel F. Alencar Laura S. Shankman Kenneth Walsh Stefan Bekiranov Olivier Kocher Monty Krieger Bengt Kull Marie Persson Erik Michaëlsson Nils Bergenhem Sepideh Heydarkhan-Hagvall Gary K. Owens Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville. (S. Shamsuzzaman, R.A.D., A.S., V.S., V.M.M., S.K. S. Saibaba, L.S.S., G.K.O.) Department of Biochemistry and Molecular Genetics, University of (…)
Circulation
Circulation, Ahead of Print. BACKGROUND:Thromboembolic events, including myocardial infarction (MI) or stroke, caused by the rupture or erosion of unstable atherosclerotic plaques are the leading cause of death worldwide. Although most mouse models of atherosclerosis develop lesions in the aorta (…) (Circulation)
11:00Deep Learning for Echo Analysis, Tracking, and Evaluation of Mitral Regurgitation (DELINEATE-MR) -
Aaron Long Christopher M. Haggerty Joshua Finer Dustin Hartzel Linyuan Jing Azadeh Keivani Christopher Kelsey Daniel Rocha Jeffrey Ruhl David vanMaanen Gil Metser Eamon Duffy Thomas Mawson Mathew Maurer Andrew J. Einstein Ashley Beecy Deepa Kumaraiah Shunichi Homma Qi Liu Vratika Agarwal Mark Lebehn Martin Leon Rebecca Hahn Pierre Elias Timothy J. Poterucha Seymour, Paul, and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center/New York–Presbyterian Hospital, NY (A.L., G.M., E.D., T.M., M.M., A.J.E., D.K., S.H., Q.L., V.A., M. Lebehn, M. (…)
Circulation
Circulation, Ahead of Print. BACKGROUND:Artificial intelligence, particularly deep learning (DL), has immense potential to improve the interpretation of transthoracic echocardiography (TTE). Mitral regurgitation (MR) is the most common valvular heart disease and presents unique challenges for (…) (Circulation)
11:00Induction of DEPP1 by HIF Mediates Multiple Hallmarks of Ischemic Cardiomyopathy -
Gregory A. Wyant Qinqin Jiang Madhu Singh Shariq Qayyum Clara Levrero Bradley A. Maron William G. Kaelin Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (G.A.W., Q.J., C.L., W.G.K.). Department of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. (B.A.M.) Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. (W.G.K.) Massachusetts General Hospital, Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Harvard Medical School, Charlestown (G.A.W., M.S., S.Q.). (…)
Circulation
Circulation, Ahead of Print. BACKGROUND:HIF (hypoxia inducible factor) regulates many aspects of cardiac function. We and others previously showed that chronic HIF activation in the heart in mouse models phenocopies multiple features of ischemic cardiomyopathy in humans, including mitochondrial (…) (Circulation)
08:00
Circulation, Volume 149, Issue 25, Page e1417-e1417, June 18, 2024. (Circulation)
08:00Effects of Dapagliflozin on Body Composition and Its Relation to Hemodynamics in Heart Failure With Preserved Ejection Fraction -
Jwan A. Naser Atsushi Tada Tomonari Harada Yogesh N.V. Reddy Rickey E. Carter Jeffrey M. Testani Michael D. Jensen Barry A. Borlaug Department of Cardiovascular Medicine (J.A.N., A.T., T.H., Y.N.V.R., B.A.B.), Mayo Clinic, Rochester, MN. Department of Medicine, Division of Endocrinology, Diabetes and Metabolism (M.D.J.), Mayo Clinic, Rochester, MN. Department of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Jacksonville, FL (R.E.C.). Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New (…)
Circulation
Circulation, Volume 149, Issue 25, Page 2026-2028, June 18, 2024. (Circulation)
08:00Legend of MERLIN and the Quest for Cardiac Lineage Commitment -
Rich Gang Li James F. Martin Cardiomyocyte Renewal Laboratory (R.G.L., J.F.M.), Houston. McGill Gene Editing Laboratory, Texas Heart Institute (R.G.L., J.F.M.), Houston. Department of Integrative Physiology (J.F.M.), Houston, TX. Center for Organ Repair and Renewal, Baylor College of Medicine (J.F.M.), Houston, TX.
Circulation
Circulation, Volume 149, Issue 25, Page 1980-1981, June 18, 2024. (Circulation)
08:00
Circulation, Volume 149, Issue 25, Page e1415-e1416, June 18, 2024. (Circulation)
08:00Trajectories in Cardiac Aging: Journey to the Crossroads of Inflammation and Metabolism -
Geneviève Derumeaux Daigo Sawaki Gabor Czibik Institut Mondor de Recherche Biomédicale, Institut national de la santé et de la recherche médicale U955, Université Paris Est Créteil (UPEC), AP-HP, Department of Physiology, Henri Mondor Hospital, FHU SENEC, Créteil, France (G.D., D.S., G.C.). Jichi Medical University, Department of Clinical Pharmacology and Cardiology, 3311-1 Shimotsuke-city, Tochigi-prefecture, Japan (D.S.). Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, (…)
Circulation
Circulation, Volume 149, Issue 25, Page 1935-1937, June 18, 2024. (Circulation)
08:00
Circulation, Volume 149, Issue 25, Page 2021-2025, June 18, 2024. (Circulation)
08:00Advanced Cardiac Patches for the Treatment of Myocardial Infarction -
Tailuo Liu Ying Hao Zixuan Zhang Hao Zhou Shiqin Peng Dingyi Zhang Ka Li Yuwen Chen Mao Chen Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases (T.L., Y.H., H.Z., S.P., D.Z., Y.C., M.C.), West China Hospital, Sichuan University, Chengdu, PR China. Department of Cardiology (T.L., S.P., D.Z., M.C.), West China Hospital, Sichuan University, Chengdu, PR China. Medicine and Engineering Interdisciplinary Research Laboratory of Nursing & Materials, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, PR China (T.L., (…)
Circulation
Circulation, Volume 149, Issue 25, Page 2002-2020, June 18, 2024. Myocardial infarction is a cardiovascular disease characterized by a high incidence rate and mortality. It leads to various cardiac pathophysiological changes, including ischemia/reperfusion injury, inflammation, fibrosis, and (…) (Circulation)