20 juin

Circulation http://ahajournals.org/

• 11:00
  CYP2C19 Genetic Testing for Oral P2Y12 Inhibitor Therapy: A Scientific Statement From the American Heart Association - Naveen L. Pereira Sharon Cresci Dominick J. Angiolillo Wayne Batchelor Quinn Capers Larisa H. Cavallari Dana Leifer Jasmine A. Luzum Dan M. Roden Konstantinos Stellos Stephanie L. Turrise Sony Tuteja Circulation
  Circulation, Ahead of Print. There is significant variability in the efficacy and safety of oral P2Y12 inhibitors, which are used to prevent ischemic outcomes in common diseases such as coronary and peripheral arterial disease and stroke. Clopidogrel, a prodrug, is the most used oral P2Y12 (…) (Circulation)

19 juin

Circulation http://ahajournals.org/

• 11:00
  Dietary Acculturation Is Associated With Altered Gut Microbiome, Circulating Metabolites, and Cardiovascular Disease Risk in US Hispanics and Latinos: Results From HCHS/SOL - Yi Wang Guo-Chong Chen Zheng Wang Kai Luo Yanbo Zhang Yang Li Amanda C. McClain Marta M. Jankowska Krista M. Perreira Josiemer Mattei Carmen R. Isasi Maria M. Llabre Bharat Thyagarajan Martha L. Daviglus Linda Van Horn David Goldsztajn Farelo Luis E. Maldonado Steven R. Levine Bing Yu Eric Boerwinkle Rob Knight Robert D. Burk Robert C. Kaplan Qibin Qi Brandilyn A. Peters Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (Y.W., G.-C.C., Z.W., K.L., Y.Z., Y.L., C.R.I., R.D.B., R.C.K., Q.Q., B.A.P.). Department of Nutrition and Food Hygiene, (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Dietary acculturation, or adoption of dominant culture diet by migrant groups, influences human health. We aimed to examine dietary acculturation and its relationships with cardiovascular disease (CVD), gut microbiota, and blood metabolites among US (…) (Circulation)
• 11:00
  Childhood Opportunity and Acute Interstage Outcomes: A National Pediatric Cardiology Quality Improvement Collaborative Analysis - Benjamin Zielonka Emily M. Bucholz Minmin Lu Katherine E. Bates Garick D. Hill Nelangi M. Pinto Lynn A. Sleeper David W. Brown Department of Cardiology, Boston Children’s Hospital and Department of Pediatrics, Harvard Medical School, MA (B.Z., M.L., L.A.S., D.W.B.). Children’s Hospital Colorado, University of Colorado, Denver (E.M.B.). C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (K.E.B.). Cincinnati Children’s Hospital Medical Center, OH (G.D.H.). Seattle Children’s Hospital, University of Washington, WA (N.M.P.). Circulation
  Circulation, Ahead of Print. BACKGROUND:The interstage period after discharge from stage 1 palliation carries high morbidity and mortality. The impact of social determinants of health on interstage outcomes is not well characterized. We assessed the relationship between childhood opportunity and (…) (Circulation)

17 juin

Circulation http://ahajournals.org/

• 11:00
  Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association - Aeron M. Small Katherine E. Yutzey Bryce A. Binstadt Kaitlin Voigts Key Nabila Bouatia-Naji David Milan Elena Aikawa Catherine M. Otto Cynthia St. Hilaire Circulation
  Circulation, Ahead of Print. Valvular heart disease is a common cause of morbidity and mortality worldwide and has no effective medical therapy. Severe disease is managed with valve replacement procedures, which entail high health care–related costs and postprocedural morbidity and mortality. (…) (Circulation)
• 11:00
  Novel Mouse Model of Myocardial Infarction, Plaque Rupture, and Stroke Shows Improved Survival With Myeloperoxidase Inhibition - Sohel Shamsuzzaman Rebecca A. Deaton Anita Salamon Heather Doviak Vlad Serbulea Victoria M. Milosek Megan A. Evans Santosh Karnewar Subhi Saibaba Gabriel F. Alencar Laura S. Shankman Kenneth Walsh Stefan Bekiranov Olivier Kocher Monty Krieger Bengt Kull Marie Persson Erik Michaëlsson Nils Bergenhem Sepideh Heydarkhan-Hagvall Gary K. Owens Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville. (S. Shamsuzzaman, R.A.D., A.S., V.S., V.M.M., S.K. S. Saibaba, L.S.S., G.K.O.) Department of Biochemistry and Molecular Genetics, University of (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Thromboembolic events, including myocardial infarction (MI) or stroke, caused by the rupture or erosion of unstable atherosclerotic plaques are the leading cause of death worldwide. Although most mouse models of atherosclerosis develop lesions in the aorta (…) (Circulation)
• 11:00
  Deep Learning for Echo Analysis, Tracking, and Evaluation of Mitral Regurgitation (DELINEATE-MR) - Aaron Long Christopher M. Haggerty Joshua Finer Dustin Hartzel Linyuan Jing Azadeh Keivani Christopher Kelsey Daniel Rocha Jeffrey Ruhl David vanMaanen Gil Metser Eamon Duffy Thomas Mawson Mathew Maurer Andrew J. Einstein Ashley Beecy Deepa Kumaraiah Shunichi Homma Qi Liu Vratika Agarwal Mark Lebehn Martin Leon Rebecca Hahn Pierre Elias Timothy J. Poterucha Seymour, Paul, and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center/New York–Presbyterian Hospital, NY (A.L., G.M., E.D., T.M., M.M., A.J.E., D.K., S.H., Q.L., V.A., M. Lebehn, M. (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Artificial intelligence, particularly deep learning (DL), has immense potential to improve the interpretation of transthoracic echocardiography (TTE). Mitral regurgitation (MR) is the most common valvular heart disease and presents unique challenges for (…) (Circulation)
• 11:00
  Induction of DEPP1 by HIF Mediates Multiple Hallmarks of Ischemic Cardiomyopathy - Gregory A. Wyant Qinqin Jiang Madhu Singh Shariq Qayyum Clara Levrero Bradley A. Maron William G. Kaelin Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (G.A.W., Q.J., C.L., W.G.K.). Department of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. (B.A.M.) Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. (W.G.K.) Massachusetts General Hospital, Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Harvard Medical School, Charlestown (G.A.W., M.S., S.Q.). (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:HIF (hypoxia inducible factor) regulates many aspects of cardiac function. We and others previously showed that chronic HIF activation in the heart in mouse models phenocopies multiple features of ischemic cardiomyopathy in humans, including mitochondrial (…) (Circulation)
• 08:00
  Response by Jeong et al to Letter Regarding Article, “Early Left Ventricular Unloading or Conventional Approach After Venoarterial Extracorporeal Membrane Oxygenation: The EARLY-UNLOAD Randomized Clinical Trial” - In-Seok Jeong Min Chul Kim Yongwhan Lim Youngkeun Ahn Department of Thoracic and Cardiovascular Surgery (I.-S.J.). Division of Cardiology, Department of Internal Medicine (M.C.K., Y.L., Y.A.), Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea. Circulation
  Circulation, Volume 149, Issue 25, Page e1417-e1417, June 18, 2024. (Circulation)
• 08:00
  Effects of Dapagliflozin on Body Composition and Its Relation to Hemodynamics in Heart Failure With Preserved Ejection Fraction - Jwan A. Naser Atsushi Tada Tomonari Harada Yogesh N.V. Reddy Rickey E. Carter Jeffrey M. Testani Michael D. Jensen Barry A. Borlaug Department of Cardiovascular Medicine (J.A.N., A.T., T.H., Y.N.V.R., B.A.B.), Mayo Clinic, Rochester, MN. Department of Medicine, Division of Endocrinology, Diabetes and Metabolism (M.D.J.), Mayo Clinic, Rochester, MN. Department of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Jacksonville, FL (R.E.C.). Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New (…) Circulation
  Circulation, Volume 149, Issue 25, Page 2026-2028, June 18, 2024. (Circulation)
• 08:00
  Legend of MERLIN and the Quest for Cardiac Lineage Commitment - Rich Gang Li James F. Martin Cardiomyocyte Renewal Laboratory (R.G.L., J.F.M.), Houston. McGill Gene Editing Laboratory, Texas Heart Institute (R.G.L., J.F.M.), Houston. Department of Integrative Physiology (J.F.M.), Houston, TX. Center for Organ Repair and Renewal, Baylor College of Medicine (J.F.M.), Houston, TX. Circulation
  Circulation, Volume 149, Issue 25, Page 1980-1981, June 18, 2024. (Circulation)
• 08:00
  Letter by Jha Regarding Article, “Early Left Ventricular Unloading or Conventional Approach After Venoarterial Extracorporeal Membrane Oxygenation: The EARLY-UNLOAD Randomized Clinical Trial” - Ajay Kumar Jha Department of Anaesthesiology and Critical Care, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India. Circulation
  Circulation, Volume 149, Issue 25, Page e1415-e1416, June 18, 2024. (Circulation)
• 08:00
  Trajectories in Cardiac Aging: Journey to the Crossroads of Inflammation and Metabolism - Geneviève Derumeaux Daigo Sawaki Gabor Czibik Institut Mondor de Recherche Biomédicale, Institut national de la santé et de la recherche médicale U955, Université Paris Est Créteil (UPEC), AP-HP, Department of Physiology, Henri Mondor Hospital, FHU SENEC, Créteil, France (G.D., D.S., G.C.). Jichi Medical University, Department of Clinical Pharmacology and Cardiology, 3311-1 Shimotsuke-city, Tochigi-prefecture, Japan (D.S.). Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, (…) Circulation
  Circulation, Volume 149, Issue 25, Page 1935-1937, June 18, 2024. (Circulation)
• 08:00
  Numbing the Heart to Death: A Cautionary Tale About an In-Vogue Preoperative Analgesic - Benjamin B. Holmes Katherine T. Murray William G. Stevenson University of South Carolina School of Medicine Greenville (B.B.H.) Vanderbilt Heart and Vascular Institute (K.T.M., W.G.S.), Vanderbilt University School of Medicine, Nashville, TN Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN (K.T.M.). Circulation
  Circulation, Volume 149, Issue 25, Page 2021-2025, June 18, 2024. (Circulation)
• 08:00
  Advanced Cardiac Patches for the Treatment of Myocardial Infarction - Tailuo Liu Ying Hao Zixuan Zhang Hao Zhou Shiqin Peng Dingyi Zhang Ka Li Yuwen Chen Mao Chen Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases (T.L., Y.H., H.Z., S.P., D.Z., Y.C., M.C.), West China Hospital, Sichuan University, Chengdu, PR China. Department of Cardiology (T.L., S.P., D.Z., M.C.), West China Hospital, Sichuan University, Chengdu, PR China. Medicine and Engineering Interdisciplinary Research Laboratory of Nursing & Materials, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, PR China (T.L., (…) Circulation
  Circulation, Volume 149, Issue 25, Page 2002-2020, June 18, 2024. Myocardial infarction is a cardiovascular disease characterized by a high incidence rate and mortality. It leads to various cardiac pathophysiological changes, including ischemia/reperfusion injury, inflammation, fibrosis, and (…) (Circulation)

14 juin

Circulation http://ahajournals.org/

• 11:00
  Endothelial Heterogeneity in the Response to Autophagy Drives Small Vessel Muscularization in Pulmonary Hypertension - Qi Zhang Nobuhiro Yaoita Arata Tabuchi Shaofei Liu Shiau-Haln Chen Qiuhua Li Niklas Hegemann Caihong Li Julie Rodor Sara Timm Hebatullah Laban Toren Finkel Troy Stevens Diego F. Alvarez Lasti Erfinanda Marc de Perrot Mariya M. Kucherenko Christoph Knosalla Matthias Ochs Stefanie Dimmeler Thomas Korff Subodh Verma Andrew H. Baker Wolfgang M. Kuebler Institute of Physiology, Charité–Universitätsmedizin, Berlin, Germany. (Q.Z., N.Y., A.T., S.L., Q.L., N.H., C.L., L.E., M.M.K., W.M.K.) Core Facility Electron Microscopy, Charité–Universitätsmedizin, Berlin, Germany. (S.T., M.O.) Institute of (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Endothelial cell (EC) apoptosis and proliferation of apoptosis-resistant cells is a hallmark of pulmonary hypertension (PH). Yet, why some ECs die and others proliferate and how this contributes to vascular remodeling is unclear. We hypothesized that this (…) (Circulation)
• 11:00
  Randomized Trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy–Statin and Eicosapentaenoic Acid (RESPECT-EPA) - Katsumi Miyauchi Hiroshi Iwata Yuji Nishizaki Teruo Inoue Atsushi Hirayama Kazuo Kimura Yukio Ozaki Toyoaki Murohara Kenji Ueshima Yoshihiro Kuwabara Sachiko Tanaka-Mizuno Naotake Yanagisawa Tosiya Sato Hiroyuki Daida Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan (K.M., H.I., Y.N., H.D.). Japan Red Cross Society, Nasu Red Cross Hospital, Otawara, Tochigi (T.I.). Dokkyo Medical University, Mibu, Tochigi, Japan (T.I.). Osaka Anti-Tuberculosis Association, Osaka Fukujyuji Hospital, Japan (A.H.). Department of Cardiology, (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Low plasma levels of eicosapentaenoic acid (EPA) are associated with cardiovascular events. This trial aimed to assess the clinical benefits of icosapent ethyl in patients with coronary artery disease, a low EPA/arachidonic acid (AA) ratio, and statin (…) (Circulation)

11 juin

Circulation http://ahajournals.org/

• 11:00
  Predicting Out-of-Hospital Cardiac Arrest in the General Population Using Electronic Health Records - Jessica Perry Jennifer A. Brody Christine Fong Jacob E. Sunshine Vikas N. O’Reilly-Shah Michael R. Sayre Thomas D. Rea Noah Simon Ali Shojaie Nona Sotoodehnia Neal A. Chatterjee Department of Biostatistics, University of Washington, Seattle (J.P., N.S., A.S.) Cardiovascular Health Research Unit, University of Washington, Seattle (J.A.B., N.S., T.D.R.) Division of Cardiology, University of Washington, Seattle (N.A.C.) Department of Medicine, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle (C.F., J.E.S., V.N.O.) Department of Emergency Medicine (M.R.S.), WA (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:The majority of out-of-hospital cardiac arrests (OHCAs) occur among individuals in the general population, for whom there is no established strategy to identify risk. In this study, we assess the use of electronic health record (EHR) data to identify OHCA (…) (Circulation)

10 juin

Circulation http://ahajournals.org/

• 08:00
  Correction to: Status and Future Directions for Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Disease With and Without Pulmonary Hypertension: A Scientific Statement From the American Heart Association Circulation
  Circulation, Volume 149, Issue 24, Page e1412-e1412, June 11, 2024. (Circulation)
• 08:00
  Correction to: 2023 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces Circulation
  Circulation, Volume 149, Issue 24, Page e1411-e1411, June 11, 2024. (Circulation)
• 08:00
  Novel Mouse Model for Selective Tagging, Purification, and Manipulation of Cardiac Myofibroblasts - Vaibhao Janbandhu Vikram Tallapragada Jinyuan Vero Li Bharti Shewale Shila Ghazanfar Ralph Patrick Charles D. Cox Richard P. Harvey Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia (V.J., V.T., J.V.L., B.S., C.D.C., R.P.H.). School of Clinical Medicine (V.J., J.V.L., R.P.H.), UNSW Sydney, Kensington, NSW 2052, Australia. School of Biomedical Sciences (C.D.C), UNSW Sydney, Kensington, NSW 2052, Australia. School of Mathematics and Statistics, Charles Perkins Centre, and Sydney Precision Data Science Centre, University of Sydney, Camperdown 2006, Australia (S.G.). (…) Circulation
  Circulation, Volume 149, Issue 24, Page 1931-1934, June 11, 2024. (Circulation)
• 08:00
  Letter by Andreotti et al Regarding Article, “Inflammation and Cholesterol as Predictors of Cardiovascular Events Among 13 970 Contemporary High-Risk Patients With Statin Intolerance” - Felicita Andreotti Francesco Burzotta Aldo Pietro Maggioni Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (F.A., F.B.). CardioThoracic Department, Catholic University Medical School, Rome, Italy (F.A., F.B.). ANMCO Research Center, Heart Care Foundation, Florence, Italy (A.P.M.). Circulation
  Circulation, Volume 149, Issue 24, Page e1312-e1312, June 11, 2024. (Circulation)
• 08:00
  Fifty Years of Cardiovascular Magnetic Resonance: Continuing Evolution Toward the “One-Stop Shop” for Cardiovascular Diagnosis - W. Gregory Hundley VCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine at Virginia Commonwealth University (VCU), Richmond. Circulation
  Circulation, Volume 149, Issue 24, Page 1859-1861, June 11, 2024. (Circulation)
• 08:00
  PVC or Not PVC? That Is the Question - Pierre Groussin Alex Melot Raphaël P. Martins Univ Rennes, CHU Rennes, INSERM, LTSI–UMR 1099, France. Circulation
  Circulation, Volume 149, Issue 24, Page 1927-1930, June 11, 2024. (Circulation)
• 08:00
  Correction to: Predicting Benefit From Evolocumab Therapy in Patients With Atherosclerotic Disease: Using a Genetic Risk Score Circulation
  Circulation, Volume 149, Issue 24, Page e1414-e1414, June 11, 2024. (Circulation)
• 08:00
  Correction to: 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines Circulation
  Circulation, Volume 149, Issue 24, Page e1413-e1413, June 11, 2024. (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 149, Issue 24, Page 1921-1926, June 11, 2024. (Circulation)
• 08:00
  A Concept of “Athero-Oncology”: Tumor-Like Smooth Muscle Cells Drive Atherosclerosis - Payel Chatterjee Kathleen A. Martin Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT. Circulation
  Circulation, Volume 149, Issue 24, Page 1899-1902, June 11, 2024. (Circulation)

6 juin

Circulation http://ahajournals.org/

• 11:00
  LncRNA DCRT Protects Against Dilated Cardiomyopathy by Preventing NDUFS2 Alternative Splicing by Binding to PTBP1 - Hengzhi Du Yanru Zhao Jianpei Wen Beibei Dai Guo Hu Yufei Zhou Zhongwei Yin Nan Ding Huaping Li Jiahui Fan Xiang Nie Feng Wang Qian Liu Zheng Wen Gang Xu Dao Wen Wang Chen Chen Divisions of Cardiology and Nephrology (G.X.) Tongji Hospital, and Department of Forensic Medicine (Q.L.) Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (H.D., Y.Z., J.W., B.D., G.H., Y.Z., Z.Y., N.D., H.L., J.F., X.N., F.W., Z.W., D.W.W., C.C.). Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, China (H.D., Y.Z., J.W., B.D., G.H., Y.Z., (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Dilated cardiomyopathy is characterized by left ventricular dilation and continuous systolic dysfunction. Mitochondrial impairment is critical in dilated cardiomyopathy; however, the underlying mechanisms remain unclear. Here, we explored the (…) (Circulation)
• 11:00
  Effect of Sacubitril/Valsartan on Cognitive Function in Patients With Heart Failure With Preserved Ejection Fraction: A Prespecified Analysis of PARAGON-HF - Pooja Dewan Li Shen João Pedro Ferreira Pardeep S. Jhund Inder S. Anand Alvin Chandra Lu-May Chiang Brian Claggett Akshay S. Desai Jianjian Gong Carolyn S.P. Lam Martin P. Lefkowitz Aldo P. Maggioni Felipe Martinez Milton Packer Margaret M. Redfield Jean L. Rouleau Dirk J. van Veldhuisen Faiez Zannad Michael R. Zile Scott D. Solomon John J.V. McMurray BHF Cardiovascular Research Centre, University of Glasgow, UK (P.D., L.S., P.S.J., J.J.V.M.). School of Clinical Medicine, Hangzhou Normal University, China (L.S.). Centre d’Investigations Cliniques Plurithématique 1433 and Inserm U1116, CHRU (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:A hypothetical concern has been raised that sacubitril/valsartan might cause cognitive impairment because neprilysin is one of several enzymes degrading amyloid-? peptides in the brain, some of which are neurotoxic and linked to Alzheimer-type dementia. To (…) (Circulation)

5 juin

Circulation http://ahajournals.org/

• 11:00
  Aortic Valve Stenosis Causes Accumulation of Extracellular Hemoglobin and Systemic Endothelial Dysfunction - Christine Quast Florian Bönner Amin Polzin Verena Veulemans Ramesh Chennupati Isabella Gyamfi Poku Susanne Pfeiler Nicolas Kramser Magdalena Nankinova Nicole Staub Elric Zweck Juliane Jokiel Fabian Keyser Jasmina Hoffe Sven Witkowski Katrin Becker Pia Leuders Saif Zako Ralf Erkens Christian Jung Ulrich Flögel Tianai Wang Michael Neidlin Ulrich Steinseifer Sven Thomas Niepmann Sebastian Zimmer Norbert Gerdes Miriam M. Cortese-Krott Martin Feelisch Tobias Zeus Malte Kelm Department of Cardiology, Pulmonology and Vascular Medicine, University Hospital, Heinrich Heine University, Düsseldorf, (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Whether aortic valve stenosis (AS) can adversely affect systemic endothelial function independently of standard modifiable cardiovascular risk factors is unknown.METHODS:We therefore investigated endothelial and cardiac function in an experimental model of (…) (Circulation)
• 11:00
  IRE1? Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts - Chao Li Shiqian Li Guangyu Zhang Qinfeng Li Weidan Song Xiaoding Wang Jane A. Cook Miesje van der Stoel Bradley W. Wright Francisco Altamirano Erica L. Niewold Jungsoo Han Garrett Kimble Pengfei Zhang Xiang Luo Hery Urra Herman I. May Anwarul Ferdous Xue-Nan Sun Yingfeng Deng Elina Ikonen Claudio Hetz Randal J. Kaufman Kezhong Zhang Thomas G. Gillette Philipp E. Scherer Joseph A. Hill Jin Chen Zhao V. Wang Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas. (C.L., G.Z., Q.L., W.S., X.W., J.A.C., E.L.N., X.L., H.I.M., A.F., (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Cardiomyocyte growth is coupled with active protein synthesis, which is one of the basic biological processes in living cells. However, it is unclear whether the unfolded protein response transducers and effectors directly take part in the control of (…) (Circulation)

4 juin

Circulation http://ahajournals.org/

• 11:00
  Forecasting the Burden of Cardiovascular Disease and Stroke in the United States Through 2050—Prevalence of Risk Factors and Disease: A Presidential Advisory From the American Heart Association - Karen E. Joynt Maddox Mitchell S.V. Elkind Hugo J. Aparicio Yvonne Commodore-Mensah Sarah D. de Ferranti William N. Dowd Adrian F. Hernandez Olga Khavjou Erin D. Michos Latha Palaniappan Joanne Penko Remy Poudel Véronique L. Roger Dhruv S. Kazi Circulation
  Circulation, Ahead of Print. BACKGROUND:Cardiovascular disease and stroke are common and costly, and their prevalence is rising. Forecasts on the prevalence of risk factors and clinical events are crucial.METHODS:Using the 2015 to March 2020 National Health and Nutrition Examination Survey and (…) (Circulation)
• 11:00
  Forecasting the Economic Burden of Cardiovascular Disease and Stroke in the United States Through 2050: A Presidential Advisory From the American Heart Association - Dhruv S. Kazi Mitchell S.V. Elkind Anne Deutsch William N. Dowd Paul Heidenreich Olga Khavjou Daniel Mark Michael E. Mussolino Bruce Ovbiagele Sonali S. Patel Remy Poudel Ben Weittenhiller Tiffany M. Powell-Wiley Karen E. Joynt Maddox Circulation
  Circulation, Ahead of Print. BACKGROUND:Quantifying the economic burden of cardiovascular disease and stroke over the coming decades may inform policy, health system, and community-level interventions for prevention and treatment.METHODS:We used nationally representative health, economic, and (…) (Circulation)
• 11:00
  Predicting the Future Prevalence of Cardiovascular Disease: The Good, the Bad, the Known, and the Unknown - Andrew E. Moran Lee Goldman Columbia University Vagelos College of Physicians and Surgeons, New York, NY; Division of General Medicine, Columbia University Irving Medical Center, New York, NY Columbia University Vagelos College of Physicians and Surgeons, New York, NY; Division of Cardiology, Columbia University Irving Medical Center, New York, NY; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY Circulation
  Circulation, Ahead of Print. (Circulation)
• 11:00
  Projections of Soaring Costs Are a Call to Arms - Elizabeth A. Magnuson Saint Luke's Mid America Heart Institute, Kansas City, MO; University of Missouri-Kansas City, Kansas City, MO Circulation
  Circulation, Ahead of Print. (Circulation)

3 juin

Circulation http://ahajournals.org/

• 08:00
  Seeing is Believing: Muscleblind-like 1 Is Necessary For Mammalian Cardiomyocyte Maturation - Khalid B. Dar Shah R. Ali Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York, NY. Circulation
  Circulation, Volume 149, Issue 23, Page 1830-1832, June 4, 2024. (Circulation)
• 08:00
  Implanted Human Cardiac Spheroids Electrically Couple With Infarcted Swine Myocardium - Bijay Guragain Yuhua Wei Hanyu Zhang Asher Kahn-Krell Lei Ye Gregory P. Walcott Jack M. Rogers Jianyi (Jay) Zhang Department of Biomedical Engineering, School of Medicine and School of Engineering.(B.G., Y.W., H.Z., A.K.-K., L.Y., G.P.W., J.M.R., J.Z.). Department of Medicine/Cardiovascular Diseases (G.P.W., J.Z), University of Alabama at Birmingham. Circulation
  Circulation, Volume 149, Issue 23, Page 1855-1857, June 4, 2024. (Circulation)
• 08:00
  The Future of Clinical Trials - Faiez Zannad Bertram Pitt Université de Lorraine, INSERM Clinical Investigation Center at Institut Lorrain du Coeur et des Vaisseaux, University Hospital of Nancy, France (F.Z.). Division of Cardiology, University of Michigan School of Medicine, Ann Arbor (B.P.). Circulation
  Circulation, Volume 149, Issue 23, Page 1783-1785, June 4, 2024. (Circulation)
• 08:00
  Pharmacogenetic Influences Over Mavacamten Pharmacokinetics: Considerations for the Treatment of Individuals With Hypertrophic Cardiomyopathy - Kathryn A. McGurk Nagme Bilgehan James S. Ware National Heart and Lung Institute and MRC Laboratory of Medical Sciences, Imperial College London, UK (K.A.M., N.B., J.S.W.). Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA (K.A.M., J.S.W.). Imperial College Healthcare NHS Trust, London, UK (J.S.W.). Royal Brompton & Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London, UK (J.S.W.). Circulation
  Circulation, Volume 149, Issue 23, Page 1786-1788, June 4, 2024. (Circulation)
• 08:00
  A Wide Complex Tachycardia - Chan-Hee Lee Emily Higgs Melvin M. Scheinman Division of Cardiology, Department of Internal Medicine, Yeungnam University Medical Center, Daegu, Republic of Korea (C.-H.L.). Cardiovascular Genetics Program (E.H.), University of California San Francisco. Division of Cardiology, Section of Electrophysiology (M.M.S.), University of California San Francisco. Circulation
  Circulation, Volume 149, Issue 23, Page 1852-1854, June 4, 2024. (Circulation)

30 mai

Circulation http://ahajournals.org/

• 11:00
  Fostering Psychological Safety and Supporting Mental Health Among Cardiovascular Health Care Workers: A Science Advisory From the American Heart Association - Laxmi S. Mehta Keith Churchwell Dawn Coleman Judy Davidson Karen Furie Nkechinyere N. Ijioma Jason N. Katz Christine Moutier Jessica Y. Rove Richard Summers Alyssa Vela Tait Shanafelt Circulation
  Circulation, Ahead of Print. The psychological safety of health care workers is an important but often overlooked aspect of the rising rates of burnout and workforce shortages. In addition, mental health conditions are prevalent among health care workers, but the associated stigma is a (…) (Circulation)

29 mai

Circulation http://ahajournals.org/

• 11:00
  Cardiovascular Magnetic Resonance Radiomics to Identify Components of the Extracellular Matrix in Dilated Cardiomyopathy - Shiro Nakamori Amine Amyar Ahmed S. Fahmy Long H. Ngo Masaki Ishida Satoshi Nakamura Taku Omori Keishi Moriwaki Naoki Fujimoto Kyoko Imanaka-Yoshida Hajime Sakuma Kaoru Dohi Warren J. Manning Reza Nezafat Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA. (S. Nakamori, A.A., A.S.F., L.H.N., W.J.M., R.N.) Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA. (W.J.M.) Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan (S. Nakamura, T.O., K.M., N.F., (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Current cardiovascular magnetic resonance sequences cannot discriminate between different myocardial extracellular space (ECSs), including collagen, noncollagen, and inflammation. We sought to investigate whether cardiovascular magnetic resonance radiomics (…) (Circulation)
• 11:00
  Evaluation and Management of Chronic Heart Failure in Children and Adolescents With Congenital Heart Disease: A Scientific Statement From the American Heart Association - Shahnawaz Amdani Jennifer Conway Kristen George Hugo R. Martinez Alfred Asante-Korang Caren S. Goldberg Ryan R. Davies Shelley D. Miyamoto Daphne T. Hsu Circulation
  Circulation, Ahead of Print. With continued medical and surgical advancements, most children and adolescents with congenital heart disease are expected to survive to adulthood. Chronic heart failure is increasingly being recognized as a major contributor to ongoing morbidity and mortality in (…) (Circulation)

28 mai

Circulation http://ahajournals.org/

• 11:00
  Atorvastatin Effect on Aortic Dilatation and Valvular Calcification Progression in Bicuspid Aortic Valve (BICATOR): A Randomized Clinical Trial - Arturo Evangelista Laura Galian-Gay Andrea Guala Gisela Teixido-Tura Francisco Calvo-Iglesias Teresa Sevilla Javier Bermejo Irene Méndez Violeta Sánchez Juan M. Robredo Carmona Josep M. Alegret Elena Ferrer-Sistach Daniel Saura Aroa Ruiz-Muñoz Lydia Dux-Santoy María Ángeles Carmona Marina Huguet Hug Cuellar-Calabria Augusto Sao-Avilés Ignacio Ferreira-González Jose F. Rodríguez-Palomares Servei de Cardiologia (A.E., L.G.-G., G.T.-T., A.R.-M., M.A.C., H.C.-C., I.F.-G., J.F.R.-P.), Hospital Universitari Vall d´Hebron, Barcelona, Spain. Servei de Radiodiagnòstic (H.C.-C.), Hospital (…) Circulation
  Circulation, Volume 149, Issue 25, Page 1938-1948, June 18, 2024. BACKGROUND:Ascending aorta dilation and aortic valve degeneration are common complications in patients with bicuspid aortic valve. Several retrospective studies have suggested the benefit of statins in reducing these (…) (Circulation)
• 11:00
  Skeletal Muscle SIRT3 Deficiency Contributes to Pulmonary Vascular Remodeling in Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction - Jia-Rong Jheng Yang Bai Kentaro Noda Joshua R. Huot Todd Cook Amanda Fisher Yi-Yun Chen Dmitry A. Goncharov Elena A. Goncharova Marc A. Simon Yingze Zhang Daniel E. Forman Mauricio Rojas Roberto F. Machado Johan Auwerx Mark T. Gladwin Yen-Chun Lai Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis. (J.-R.J., Y.B., T.C., A.F., R.F.M., Y.-C.L.) Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis. (J.R.H., R.F.M., Y.-C.L.) Department of Clinical Pharmacology, School of (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Pulmonary hypertension (PH) is a major complication linked to adverse outcomes in heart failure with preserved ejection fraction (HFpEF), yet no specific therapies exist for PH associated with HFpEF (PH-HFpEF). We have recently reported on the role of (…) (Circulation)
• 08:00
  Centennial Collection: Health Applications of Digital Technologies - Seth S. Martin Digital Health Laboratory, Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD. American Heart Association Health Technologies and Innovation Strategically Focused Research Network, Johns Hopkins mTECH Center, Baltimore, MD. Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, MD. Circulation
  Circulation, Volume 149, Issue 22, Page 1701-1703, May 28, 2024. (Circulation)
• 08:00
  Evolving Cardiac Safety in Drug Discovery: Time for Immunology Integration - Jose M. Vicencio Caroline R. Archer Amy Pointon Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom. Circulation
  Circulation, Volume 149, Issue 22, Page 1704-1707, May 28, 2024. (Circulation)
• 08:00
  Letter by Cardinale et al Regarding Article, “Multicenter, Prospective, Randomized Controlled Trial of High-Sensitivity Cardiac Troponin I–Guided Combination Angiotensin Receptor Blockade and Beta-Blocker Therapy to Prevent Anthracycline Cardiotoxicity: The Cardiac CARE Trial” - Daniela Cardinale Alexander R. Lyon Teresa López-Fernández Cardioncology Unit, European Institute of Oncology, IRCCS, Milan, Italy (D.C.). Cardio-Oncology Service, Royal Brompton & Harefield NHS Foundation Trust and the National Heart & Lung Institute, Imperial College London, UK (A.R.L.). Cardiology Department, La Paz University Hospital, IdiPAZ Research Institute, Madrid, Spain (T.L.-F.). Cardiology Department, Quiron Pozuelo University Hospital, Madrid, Spain (T.L.-F.). Circulation
  Circulation, Volume 149, Issue 22, Page e1219-e1220, May 28, 2024. (Circulation)
• 08:00
  Response by Henriksen et al Regarding Article, “Multicenter, Prospective, Randomized Controlled Trial of High-Sensitivity Cardiac Troponin I–Guided Combination Angiotensin Receptor Blockade and Beta-Blocker Therapy to Prevent Anthracycline Cardiotoxicity: The Cardiac CARE Trial” - Peter A. Henriksen Peter Hall Ninian N. Lang British Heart Foundation Centre for Cardiovascular Science (P.A.H.), University of Edinburgh, UK. Cancer Research UK – Edinburgh Centre (P.H.), University of Edinburgh, UK. Medical Research Council Institute Genetics and Molecular Medicine (P.H.), University of Edinburgh, UK. School of Cardiovascular and Metabolic Health, University of Glasgow, UK (N.N.L.). Circulation
  Circulation, Volume 149, Issue 22, Page e1221-e1222, May 28, 2024. (Circulation)
• 08:00
  MicroRNA-122–Mediated Liver Detargeting Enhances the Tissue Specificity of Cardiac Genome Editing - Luzi Yang Zhanzhao Liu Gonglie Chen Zhan Chen Congting Guo Xiangwen Ji Qinghua Cui Yueshen Sun Xiaomin Hu Yanjiang Zheng Yifei Li Fei Gao Liang Chen Pingzhu Zhou William T. Pu Yuxuan Guo School of Basic Medical Sciences and Institute of Cardiovascular Sciences (L.Y., Z.L., G.C., Z.C., C.G., Y.G.), Peking University Health Science Center, Beijing, China. School of Basic Medical Sciences Department of Biomedical Informatics, Center for Noncoding RNA Medicine (Q.C.), Peking University Health Science Center, Beijing, China. State Key Laboratory of Vascular Homeostasis and Remodeling, Peking (…) Circulation
  Circulation, Volume 149, Issue 22, Page 1778-1781, May 28, 2024. (Circulation)
• 08:00
  Extracellular Vesicles: Bridging the Heart and Tumor in Reverse Cardio-Oncology - Alexandra A.C. Newman Richard Von Itter Kathryn J. Moore Cardiovascular Research Center, Leon H. Charney Division of Cardiology, Department of Medicine, New York University Langone Health (A.A.C.N., R.V.I., K.J.M.). Department of Cell Biology, New York University Grossman School of Medicine (K.J.M.). Circulation
  Circulation, Volume 149, Issue 22, Page 1749-1751, May 28, 2024. (Circulation)
• 08:00
  Double Whammy Complicating Management of Pulmonary Hypertension - Ayesha Salahuddin Ian S. Harris Aarthi Sabanayagam Department of Medicine, Division of Cardiology, University of California San Francisco. Circulation
  Circulation, Volume 149, Issue 22, Page 1770-1774, May 28, 2024. (Circulation)

20 mai

Circulation http://ahajournals.org/

• 11:00
  Implementation of Obesity Science Into Clinical Practice: A Scientific Statement From the American Heart Association - Deepika Laddu Ian J. Neeland Mercedes Carnethon Fatima C. Stanford Morgana Mongraw-Chaffin Bethany Barone Gibbs Chiadi E. Ndumele Chris T. Longenecker Misook L. Chung Goutham Rao Circulation
  Circulation, Ahead of Print. Obesity is a recognized public health epidemic with a prevalence that continues to increase dramatically in nearly all populations, impeding progress in reducing incidence rates of cardiovascular disease. Over the past decade, obesity science has evolved to improve (…) (Circulation)
• 08:00
  Pursuing P Waves - Bharath Peddibhotla Kenneth A. Ellenbogen Ajay Pillai Department of Internal Medicine (B.P.), VCU Health, Richmond, VA. Division of Cardiac Electrophysiology (K.E., A.P.), VCU Health, Richmond, VA. Circulation
  Circulation, Volume 149, Issue 21, Page 1689-1692, May 21, 2024. (Circulation)
• 08:00
  Correction to: 2022 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces Circulation
  Circulation, Volume 149, Issue 21, Page e1218-e1218, May 21, 2024. (Circulation)
• 08:00
  Leveraging Human Tissue for Discovery in Heart Transplantation - Kory Lavine Center for Cardiovascular Research, Department of Medicine, Cardiovascular Division, Department of Pathology and Immunology, Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO. Circulation
  Circulation, Volume 149, Issue 21, Page 1667-1669, May 21, 2024. (Circulation)
• 08:00
  Correction to: Organ Donation After Out-of-Hospital Cardiac Arrest: A Scientific Statement From the International Liaison Committee on Resuscitation Circulation
  Circulation, Volume 149, Issue 21, Page e1217-e1217, May 21, 2024. (Circulation)
• 08:00
  Detection of Circulating Transthyretin Amyloid Aggregates in Plasma: A Novel Biomarker for Transthyretin Amyloidosis - Rose Pedretti Lanie Wang Mazen Hanna Merrill D. Benson Justin L. Grodin W.H. Wilson Tang Ahmad Masri Lorena Saelices Center for Alzheimer’s and Neurodegenerative Diseases, Department of Biophysics, Peter O’Donnell Jr. Brain Institute (R.P., L.W., L.S.), University of Texas Southwestern Medical Center, Dallas. Division of Cardiology, Department of Internal Medicine (J.L.G.), University of Texas Southwestern Medical Center, Dallas. Department of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic, OH (M.H., W.H.W.T.). Department of Pathology and Laboratory (…) Circulation
  Circulation, Volume 149, Issue 21, Page 1696-1699, May 21, 2024. (Circulation)
• 08:00
  Type 1 Brugada Pattern May Be Provoked by Ajmaline in Some Healthy Subjects: Results From a Clinical Trial - Bode Ensam Chiara Scrocco David Johnson Yanushi D. Wijeyeratne Rachel Bastiaenen Belinda Gray Chris Miles Yael Ben-Haim Stathis Papatheodorou Sanjay Sharma Michael Papadakis Brian Devine Peter W. Macfarlane Elijah R. Behr Cardiology Section and Cardiovascular Clinical Academic Group, St. George’s University Hospitals NHS Foundation Trust, and Institute of Molecular and Clinical Sciences, St. George’s University of London, UK (B.E., C.S., D.J., Y.D.W., R.B., B.G., C.M., Y.B.-H., S.P., S.S., M.P., E.R.B.). Electrocardiology Group, School of Health and Wellbeing, University of Glasgow, (…) Circulation
  Circulation, Volume 149, Issue 21, Page 1693-1695, May 21, 2024. (Circulation)
• 08:00
  Letter by Chen et al Regarding Article, “Reduced Mitochondrial Protein Translation Promotes Cardiomyocyte Proliferation and Heart Regeneration” - Yunan Chen Sixiang Lin Mingge Ding Department of Geriatrics Cardiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, China. Key Laboratory of Surgical Critical Care and Life Support, Xi’an Jiaotong University, Ministry of Education, Shaanxi, China. Circulation
  Circulation, Volume 149, Issue 21, Page e1194-e1194, May 21, 2024. (Circulation)
• 08:00
  Response by Gao et al to Letter Regarding Article, “Reduced Mitochondrial Protein Translation Promotes Cardiomyocyte Proliferation and Heart Regeneration” - Feng Gao John D. Mably Da-Zhi Wang Jinghai Chen Department of Cardiology, State Key Laboratory of Transvascular Implantation Devices, Second Affiliated Hospital (F.G., J.C.), Zhejiang University School of Medicine, Hangzhou, China. Institute of Translational Medicine (F.G., J.C.), Zhejiang University School of Medicine, Hangzhou, China. Center for Regenerative Medicine, University of South Florida Health Heart Institute, Tampa (J.D.M., D.-Z.W.). Departments of Internal Medicine and Molecular Pharmacology and Physiology, Morsani School of Medicine, University of South Florida, Tampa (…) Circulation
  Circulation, Volume 149, Issue 21, Page e1195-e1196, May 21, 2024. (Circulation)
• 08:00
  Ceramides and Atherosclerotic Cardiovascular Disease: A Current Perspective - Qingzhang Zhu Philipp E. Scherer Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas. Circulation
  Circulation, Volume 149, Issue 21, Page 1624-1626, May 21, 2024. (Circulation)
• 08:00
  Obesity and Cardiovascular Disease: A New Dawn - Naveed Sattar Ian J. Neeland Darren K. McGuire School of Cardiovascular and Metabolic Health, University of Glasgow, UK (N.S.). Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, OH (I.J.N.). University of Texas Southwestern Medical Center and Parkland Health, Dallas (D.K.M.). Circulation
  Circulation, Volume 149, Issue 21, Page 1621-1623, May 21, 2024. (Circulation)

16 mai

Circulation http://ahajournals.org/

• 11:00
  Randomized, Multicenter Study to Assess the Effects of Different Doses of Sildenafil on Mortality in Adults With Pulmonary Arterial Hypertension - Marius M. Hoeper Ralf Ewert Pavel Jansa Yuriy Sirenko Andris Skride Cecile Balagtas Sarah Hackley Susanne Vogt Paula Abreu Scott Haughie Tarek Hassan Ronald J. Oudiz Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Germany (M.M.H.). German Center for Lung Research, Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Germany (M.M.H.). Department of Respiratory Medicine, Universitätsmedizin Greifswald, Germany (R.E.). Department of Cardiovascular Medicine, General University Hospital, Prague, Czech Republic (P.J.). NSC MD (…) Circulation
  Circulation, Volume 149, Issue 25, Page 1949-1959, June 18, 2024. BACKGROUND:Sildenafil, approved for pulmonary arterial hypertension (PAH), has a recommended adult dose of 20 mg TID, with a previously approved 5-mg TID dose by the US Food and Drug Administration. Safety concerns arose because (…) (Circulation)
• 11:00
  Genome-Wide CRISPR Screen Identifies an NF2-Adherens Junction Mechanistic Dependency for Cardiac Lineage - Chang Jie Mick Lee Matias I. Autio Wenhao Zheng Yoohyun Song Shyi Chyi Wang Darren Chen Pei Wong Jingwei Xiao Yike Zhu Permeen Yusoff Xi Yei Wan Kee Chock Boon Chuan Low Marius Sudol Roger S.-Y. Foo Cardiovascular Metabolic Disease Translational Research Programme, National University Health System, Centre for Translational Medicine, Singapore (C.J.M.L., W.H.Z., Y.Z., P.Y., X.Y., R.S.-Y.F.). Institute of Molecular and Cell Biology, Singapore (C.J.M.L., Y.Z., R.S.-Y.F.). Genome Institute of Singapore (M.I.A., W.K.C.). Mechanobiology Institute Singapore (Y.S., S.C.W., D.C.P.W., J.X., (…) Circulation
  Circulation, Volume 149, Issue 25, Page 1960-1979, June 18, 2024. BACKGROUND:Cardiomyocyte differentiation involves a stepwise clearance of repressors and fate-restricting regulators through the modulation of BMP (bone morphogenic protein)/Wnt-signaling pathways. However, the mechanisms and how (…) (Circulation)
• 11:00
  Allele-Specific Suppression of Variant MHC With High-Precision RNA Nuclease CRISPR-Cas13d Prevents Hypertrophic Cardiomyopathy - Ping Yang Yingmei Lou Zilong Geng Zhizhao Guo Shuo Wu Yige Li Kaiyuan Song Ting Shi Shasha Zhang Junhao Xiong Alex F. Chen Dali Li William T. Pu Lintai Da Yan Zhang Kun Sun Bing Zhang Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Engineering Research Center of Techniques and Instruments for Diagnosis and Treatment of Congenital Heart Disease, Institute for Developmental and Regenerative Medicine, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China (P.Y., Y. Lou, Z. Geng, Z. Guo, S.W., Y. Li, K.S., S.Z., J.X., A.F.C., L.D., (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Familial hypertrophic cardiomyopathy has severe clinical complications of heart failure, arrhythmia, and sudden cardiac death. Heterozygous single nucleotide variants (SNVs) of sarcomere genes such asMYH7are the leading cause of this type of disease. (…) (Circulation)
• 06:00
  Early Versus Late Initiation of Direct Oral Anticoagulants After Ischemic Stroke in People With Atrial Fibrillation and Hemorrhagic Transformation: Prespecified Subanalysis of the Randomized-controlled ELAN Trial - Roman Rohner Markus Kneihsl Martina B. Goeldlin Arsany Hakim Mattia Branca Stefanie Abend Waldo Valenzuela Pinilla Sabine Fenzl Beata Rezny-Kasprzak Daniel Strbian Sven Trelle Maurizio Paciaroni Götz Thomalla Patrik Michel Krassen Nedeltchev Thomas Gattringer Else C. Sandset Leo Bonati Diana Aguiar de Sousa P.N. Sylaja George Ntaios Masatoshi Koga Zuzana Gdovinova Robin Lemmens Natan M. Bornstein Peter Kelly Mira Katan Thomas Horvath Jesse Dawson Urs Fischer University Institute of Diagnostic and Interventional Neuroradiology, Inselspital Bern University Hospital and University of Bern, (…) Circulation
  Circulation, Ahead of Print. Background: Whether hemorrhagic transformation (HT) modifies the treatment effect of early versus late initiation of direct oral anticoagulation (DOAC) in people with ischemic stroke and atrial fibrillation is unknown.Methods: This is a post-hoc analysis of the ELAN (…) (Circulation)

14 mai

Circulation http://ahajournals.org/

• 11:45
  Influence of Pathophysiological Patterns of Coronary Artery Disease on Immediate Percutaneous Coronary Intervention Outcomes - Carlos Collet Daniel Munhoz Takuya Mizukami Jeroen Sonck Hitoshi Matsuo Toshiro Shinke Hirohiko Ando Brian Ko Simone Biscaglia Fernando Rivero Thomas Engstrøm Ketina Arslani Antonio Maria Leone Lokien X. van Nunen William F. Fearon Evald Høj Christiansen Stephane Fournier Liyew Desta Andy Yong Julien Adjej Javier Escaned Masafumi Nakayama Ashkan Eftekhari Frederik M. Zimmermann Koshiro Sakai Tatyana Storozhenko Bruno R. da Costa Gianluca Campo Nick E.J. West Tom De Potter Ward Heggermont Dimitri Buytaert Jozef Bartunek Colin Berry Damien Collison Thomas Johnson Tetsuya Amano Divaka Perera (…) Circulation
  Circulation, Ahead of Print. Background: Diffuse coronary artery disease (CAD) impacts the safety and efficacy of percutaneous coronary intervention (PCI). Pathophysiological CAD patterns can be quantified using fractional flow reserve (FFR) pullbacks incorporating the pullback pressure gradient (…) (Circulation)
• 08:00
  2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines - Heather L. Gornik Herbert D. Aronow Philip P. Goodney Shipra Arya Luke Packard Brewster Lori Byrd Venita Chandra Douglas E. Drachman Jennifer M. Eaves Jonathan K. Ehrman John N. Evans Thomas S.D. Getchius J. Antonio Gutiérrez Beau M. Hawkins Connie N. Hess Karen J. Ho W. Schuyler Jones Esther S.H. Kim Scott Kinlay Lee Kirksey Debra Kohlman-Trigoboff Chandler A. Long Amy West Pollak Saher S. Sabri Lawrence B. Sadwin Eric A. Secemsky Maya Serhal Mehdi H. Shishehbor Diane Treat-Jacobson Luke R. Wilkins *Writing committee members are required to recuse themselves from voting on sections to (…) Circulation
  Circulation, Volume 149, Issue 24, Page e1313-e1410, June 11, 2024. AIM:The “2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease” provides recommendations to guide clinicians in the treatment of patients with lower (…) (Circulation)
• 03:15
  Effect of Cangrelor on Infarct Size in ST-Segment Elevation Myocardial Infarction Treated By Primary Percutaneous Coronary Intervention: A Randomized Controlled Trial (The PITRI Trial) - Heerajnarain Bulluck Jun Hua Chong Jennifer Bryant Annitha Annathurai Ping Chai Mervyn Chan Ashish Chawla Chee Yang Chin Yiu-Cho Chung Fei Gao Hee Hwa Ho Andrew Fu Wah Ho John Hoe Syed Saqib Imran Chi-Hang Lee Benji Lim Soo Teik Lim Swee Han Lim Boon Wah Liew Patrick Lim Zhan Yun Marcus Eng Hock Ong Valeria Paradies Xuan Ming Pung Julian Cheong Kiat Tay Lynette Teo Boon Ping Ting Aaron Wong Evelyn Wong Timothy Watson Mark Y. Chan Yeo Khung Keong Jack W.C Tan Derek J. Hausenloy Leeds Teaching Hospital NHS Trust, Leeds, UK; Leeds Institute of Cardiovascular and Metabolic Medicine, University (…) Circulation
  Circulation, Ahead of Print. Background:The administration of intravenous cangrelor at reperfusion achieves faster onset of platelet P2Y12 inhibition than oral ticagrelor and has been shown to reduce myocardial infarct (MI) size in the pre-clinical setting. We hypothesized that the (…) (Circulation)
• 08:00
  Stepping Into the Future of Care for Patients With Peripheral Artery Disease - Marc P. Bonaca Naomi M. Hamburg Mark A. Creager University of Colorado School of Medicine, CPC Clinical Research, Aurora (M.P.B.). Boston University Chobanian and Avedisian School of Medicine, MA (N.M.H.). Dartmouth Health and Geisel School of Medicine at Dartmouth, Lebanon, NH (M.A.C.). Circulation
  Circulation, Volume 149, Issue 24, Page 1862-1864, June 11, 2024. (Circulation)

13 mai

Circulation http://ahajournals.org/

• 08:00
  Closure of Coal-Burning Plant in Pittsburgh Linked to Big Reductions in Heart-Related Emergency Department Visits and Hospitalizations - Bridget M. Kuehn Circulation
  Circulation, Volume 149, Issue 20, Page 1611-1613, May 14, 2024. (Circulation)
• 08:00
  Is There a Role for Calcium Channel Blockers in the Contemporary Treatment Paradigm for Pulmonary Arterial Hypertension? - Lewis J. Rubin Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY. Department of Medicine, School of Medicine, University of California, San Diego, La Jolla. Circulation
  Circulation, Volume 149, Issue 20, Page 1565-1567, May 14, 2024. (Circulation)
• 08:00
  Correction to: An Aspirin-Free Versus Dual Antiplatelet Strategy for Coronary Stenting: STOPDAPT-3 Randomized Trial Circulation
  Circulation, Volume 149, Issue 20, Page e1189-e1190, May 14, 2024. (Circulation)
• 08:00
  Augmented Cardiac Inotropy by Phosphodiesterase Inhibition Requires Phosphorylation of Rad and Increased Calcium Current - Alexander N. Katchman Sergey I. Zakharov Michael S. Bohnen Alejandro Sanchez Jimenez Jared S. Kushner Lin Yang Bi-xing Chen Amina Nasari Guoxia Liu David E. Rabbani Jiying Han Cheng-Shiun Leu Geoffrey S. Pitt Steven O. Marx Division of Cardiology, Department of Medicine (A.N.K., S.I.Z., M.S.B., A.S.J., J.S.K., L.Y., B.-x.C., A.N., G.L., D.E.R., S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY. Department of Pharmacology and Molecular Signaling (S.O.M.), Columbia University, Vagelos College of Physicians and Surgeons, New York, NY. CUNY School of (…) Circulation
  Circulation, Volume 149, Issue 20, Page 1617-1620, May 14, 2024. (Circulation)
• 08:00
  Unraveling the Complex Relationship Between Gut Microbiome and Cardiovascular Diseases - W.H. Wilson Tang Stanley L. Hazen Center for Microbiome and Human Health, Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Department of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic, OH. Circulation
  Circulation, Volume 149, Issue 20, Page 1543-1545, May 14, 2024. (Circulation)
• 08:00
  Win Ratio: A Seductive But Potentially Misleading Method for Evaluating Evidence from Clinical Trials - Javed Butler Norman Stockbridge Milton Packer Baylor Scott and White Research Institute (J.B.), Dallas, TX. Baylor University Medical Center (M.P.), Dallas, TX. University of Mississippi, Jackson, MS (J.B.). Food and Drug Administration, Silver Spring, MD (N.S.). Imperial College, London, UK (M.P.). Circulation
  Circulation, Volume 149, Issue 20, Page 1546-1548, May 14, 2024. (Circulation)
• 08:00
  Metabolic Reprogramming: A Byproduct or a Driver of Cardiomyocyte Proliferation? - Xiaokang Chen Hao Wu Ya Liu Lingyan Liu Steven R. Houser Wei Eric Wang Department of Geriatrics (X.C., H.W., Y.L., L.L., W.E.W.), Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. Cardiovascular Center (X.C., H.W., Y.L., L.L., W.E.W.), Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. Independence Blue Cross Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA (S.R.H.). Circulation
  Circulation, Volume 149, Issue 20, Page 1598-1610, May 14, 2024. Defining mechanisms of cardiomyocyte proliferation should guide the understanding of endogenous cardiac regeneration and could lead to novel treatments for diseases such as myocardial infarction. In the neonatal heart, energy (...) (Circulation)
• 08:00
  Left Ventricular Hypertrophy With Preexcitation - Maithree Mahesh Mohsin Raj Mantoo Nayani Makkar Department of Pediatrics, Saveetha Medical College and Hospital, Kanchipuram, India (M.M.). Department of Cardiology, All India Institute of Medical Sciences, New Delhi (M.R.M.). Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India (N.M.). Circulation
  Circulation, Volume 149, Issue 20, Page 1614-1616, May 14, 2024. (Circulation)

11 mai

Circulation http://ahajournals.org/

• 12:15
  Redefining Iron Deficiency in Patients With Chronic Heart Failure - Milton Packer Stefan D. Anker Javed Butler John G.F. Cleland Paul R. Kalra Robert J. Mentz Piotr Ponikowski Khawaja M. Talha Baylor University Medical Center, Dallas, TX; Imperial College, London, UK Department of Cardiology of German Heart Center Charité, Institute of Health Center for Regenerative Therapies, German Centre for Cardiovascular Research, partner site Berlin, Charité Universitätsmedizin, Berlin, Germany Baylor Scott and White Research Institute, Baylor University Medical Center, Dallas, TX; University of Mississippi Medical Center, Jackson, MS British Heart Foundation Centre (…) Circulation
  Circulation, Ahead of Print. (Circulation)
• 09:30
  Timing of Cardio-Kidney Protection With SGLT2 Inhibitors: Insights From Four Large-Scale Placebo-Controlled Outcome Trials - Brendon L. Neuen Brian L. Claggett Vlado Perkovic Meg Jardine Hiddo J.L. Heerspink Kenneth W. Mahaffey John J.V. McMurray Scott D. Solomon Muthiah Vaduganathan Division of Cardiovascular Medicine, Center for Cardiometabolic Implementation Science, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; The George Institute for Global Health, University of New South Wales, Sydney, Australia; Department of Renal Medicine, Royal North Shore Hospital, Sydney, Australia Division of Cardiovascular Medicine, Center for Cardiometabolic Implementation Science, Brigham and Women's (…) Circulation
  Circulation, Ahead of Print. (Circulation)

10 mai

Circulation http://ahajournals.org/

• 11:00
  Spexin Diminishes Atrial Fibrillation Vulnerability by Acting on Galanin Receptor 2 - Desheng Li Yang Liu Changzhu Li Zhiwen Zhou Kangyi Gao Hairong Ba Jiming Yang Genlong Xue Dechun Yin Xinbo Zhao Kewei Shen Lingmin Zhang Jialiang Li Chenhong Li Jiahui Song Lexin Zhao Yao Pei Lina Xuan Yang Zhang Yanjie Lu Zhi-Ren Zhang Baofeng Yang Yue Li Zhenwei Pan National Key Laboratory of Frigid Zone Cardiovascular Diseases, Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, International Cooperation Base for Major Cardiovascular Diseases in Cold Regions, China), College (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:G protein–coupled receptors play a critical role in atrial fibrillation (AF). Spexin is a novel ligand of galanin receptors (GALRs). In this study, we investigated the regulation of spexin and GALRs on AF and the underlying mechanisms.METHODS:Global spexin (…) (Circulation)

8 mai

Circulation http://ahajournals.org/

• 08:00
  2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines - Steve R. Ommen Carolyn Y. Ho Irfan M. Asif Seshadri Balaji Michael A. Burke Sharlene M. Day Joseph A. Dearani Kelly C. Epps Lauren Evanovich Victor A. Ferrari José A. Joglar Sadiya S. Khan Jeffrey J. Kim Michelle M. Kittleson Chayakrit Krittanawong Matthew W. Martinez Seema Mital Srihari S. Naidu Sara Saberi Christopher Semsarian Sabrina Times Cynthia Burstein Waldman *Writing committee members are required to recuse themselves from voting on sections to which their specific relationships with industry may apply; see Appendix 1 for detailed information. †AMSSM representative. ‡HRS (…) Circulation
  Circulation, Volume 149, Issue 23, Page e1239-e1311, June 4, 2024. AIM:The “2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy” provides recommendations to guide clinicians in the management of patients with hypertrophic cardiomyopathy.METHODS:A (...) (Circulation)

6 mai

Circulation http://ahajournals.org/

• 11:00
  Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis - Feng Xiao Ngoc Uyen Nhi Nguyen Ping Wang Shujuan Li Ching-Cheng Hsu Suwannee Thet Wataru Kimura Xiang Luo Nicholas T. Lam Ivan Menendez-Montes Waleed Elhelaly Alisson Campos Cardoso Ana Helena Macedo Pereira Rohit Singh Sakthivel Sadayappan Mohammed Kanchwala Chao Xing Feria A. Ladha J. Travis Hinson Roger J. Hajjar Joseph A. Hill Hesham A. Sadek Departments of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas. (F.X., N.U.N.N., P.W., S.L., C.-C.H., S.T., W.K., X.L., N.T.L., I.M.-M., W.E., A.C.C., A.H.M.P., J.A.H., H.A.S.) Eugene McDermott Center for (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Recent interest in understanding cardiomyocyte cell cycle has been driven by potential therapeutic applications in cardiomyopathy. However, despite recent advances, cardiomyocyte mitosis remains a poorly understood process. For example, it is unclear how (…) (Circulation)
• 11:00
  Inhibition of Hmbox1 Promotes Cardiomyocyte Survival and Glucose Metabolism Through Gck Activation in Ischemia/Reperfusion Injury - Yihua Bei Yujiao Zhu Jingwen Zhou Songwei Ai Jianhua Yao Mingming Yin Meiyu Hu Weitong Qi Michail Spanos Lin Li Meng Wei Zhenzhen Huang Juan Gao Chang Liu Petra H. van der Kraak Guoping Li Zhiyong Lei Joost P. G. Sluijter Junjie Xiao Institute of Geriatrics, Affiliated Nantong Hospital (Sixth People’s Hospital of Nantong) and School of Life Science (Y.B., Y.Z., J.Z., S.A., M.Y., M.H., W.Q., L.L., M.W., Z.H., J.G., C.L., J.X.), Shanghai University, Nantong, China. Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), Shanghai (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Exercise-induced physiological cardiac growth regulators may protect the heart from ischemia/reperfusion (I/R) injury. Homeobox-containing 1 (Hmbox1), a homeobox family member, has been identified as a putative transcriptional repressor and is (…) (Circulation)
• 08:00
  Stroke Science and Care Since the Founding of the American Heart Association - Mitchell S.V. Elkind American Heart Association, Dallas, TX. Department of Neurology, Vagelos College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY. Circulation
  Circulation, Volume 149, Issue 19, Page 1469-1470, May 7, 2024. (Circulation)
• 08:00
  Will HIV Break the Heart of Africans? - Roger J. Bedimo Fiona Strasserking Pablo Tebas Department of Medicine, VA North Texas Health Care System, Dallas (R.J.B.). Department of Medicine, University of Texas Southwestern Medical Center at Dallas (R.J.B., F.S.). Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia (P.T.). Circulation
  Circulation, Volume 149, Issue 19, Page 1471-1473, May 7, 2024. (Circulation)
• 08:00
  Identifying Cardiomyocyte Ploidy With Nuclear Area and Volume - Zehao Yao Lina Bai Kefei Dou Yu Nie State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (Z.Y., L.B., K.D., Y.N.). Shenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital Chinese Academy of Medical Sciences, China (Y.N.). National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine, Fuwai Central-China Hospital, Central China Branch of National Center for Cardiovascular Diseases, Zhengzhou, China (Y.N.). Circulation
  Circulation, Volume 149, Issue 19, Page 1540-1542, May 7, 2024. (Circulation)
• 08:00
  Low-Dose Rivaroxaban Plus Aspirin in Patients With Peripheral Artery Disease Undergoing Lower Extremity Revascularization With and Without Concomitant Coronary Artery Disease: Insights From VOYAGER PAD - Justin T. Morrison Mario Enrico Canonico Sonia S. Anand Manesh R. Patel Eike Sebastian Debus Mark R. Nehler Connie N. Hess Judith Hsia Warren H. Capell Eva Muehlhofer Lloyd P. Haskell Scott D. Berkowitz Rupert M. Bauersachs Marc P. Bonaca Colorado Prevention Center Clinical Research, Aurora, CO (J.T.M., M.E.C., M.R.N., C.N.H., J.H., W.H.C., S.D.B., M.P.B.). Division of Cardiology (J.T.M., M.E.C., C.N.H., J.H., S.D.B., M.P.B.), University of Colorado School of Medicine, Aurora. Division of Endocrinology (W.H.C.), University of Colorado School of Medicine, Aurora. Division of Hematology (…) Circulation
  Circulation, Volume 149, Issue 19, Page 1536-1539, May 7, 2024. (Circulation)
• 08:00
  Correction to: 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association Circulation
  Circulation, Volume 149, Issue 19, Page e1164-e1164, May 7, 2024. (Circulation)
• 08:00
  From the Literature - Tracy Hampton Circulation
  Circulation, Volume 149, Issue 19, Page 1534-1535, May 7, 2024. (Circulation)
• 08:00
  Unlocking Pathways That Improve Cardiac Function in Chronic Heart Failure: Are Ketones the Key? - Satyam Sarma Jason R.B. Dyck Institute for Exercise and Environmental Medicine, University of Texas Southwestern Medical Center, Dallas (S.S.). Cardiovascular Research Centre, Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Canada (J.R.B.D.). Circulation
  Circulation, Volume 149, Issue 19, Page 1490-1492, May 7, 2024. (Circulation)

2 mai

Circulation http://ahajournals.org/

• 11:00
  Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension - Haiyang Tang Akash Gupta Seth A. Morrisroe Changlei Bao Tae-Hwi Schwantes-An Geetanjali Gupta Shuxin Liang Yanan Sun Aiai Chu Ang Luo Venkateswaran Ramamoorthi Elangovan Shreya Sangam Yinan Shi Samisubbu R. Naidu Jia-Rong Jheng Sultan Ciftci-Yilmaz Noel A. Warfel Louise Hecker Sumegha Mitra Anna W. Coleman Katie A. Lutz Michael W. Pauciulo Yen-Chun Lai Ali Javaheri Rohan Dharmakumar Wen-Hui Wu Daniel P. Flaherty Jason H. Karnes Sandra Breuils-Bonnet Olivier Boucherat Sebastien Bonnet Jason X.-J. Yuan Jeffrey R. Jacobson Julio D. Duarte William C. Nichols Joe G.N. Garcia Ankit A. Desai (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:The ubiquitin-proteasome system regulates protein degradation and the development of pulmonary arterial hypertension (PAH), but knowledge about the role of deubiquitinating enzymes in this process is limited. UCHL1 (ubiquitin carboxyl-terminal hydrolase (…) (Circulation)

1er mai

Circulation http://ahajournals.org/

• 11:00
  Ertugliflozin for Functional Mitral Regurgitation Associated With Heart Failure: EFFORT Trial - Duk-Hyun Kang Sung-Ji Park Sung-Hee Shin In-Chang Hwang Yeonyee Elizabeth Yoon Hyung-Kwan Kim Mijin Kim Min-Seok Kim Sung-Cheol Yun Jong-Min Song Seok-Min Kang Division of Cardiology, Clinical Epidemiology and Biostatistics (S.-C.Y.), College of Medicine, University of Ulsan, Seoul, Korea. Asan Medical Center (D.-H.K., M.-S.K., J.-M.S.), College of Medicine, University of Ulsan, Seoul, Korea. Division of Cardiology, Samsung Medical Center, Seoul, Korea (S.-J.P.). Division of Cardiology, Department of Internal Medicine, College of Medicine, Inha University, Incheon, Korea (S.-H.S.). (…) Circulation
  Circulation, Volume 149, Issue 24, Page 1865-1874, June 11, 2024. BACKGROUND:The morbidity and mortality rates of patients with heart failure (HF) and functional mitral regurgitation (MR) remain substantial despite guideline-directed medical therapy for HF. We evaluated the efficacy of (…) (Circulation)

30 avril

Circulation http://ahajournals.org/

• 11:00
  Rectifying METTL4-Mediated N6-Methyladenine Excess in Mitochondrial DNA Alleviates Heart Failure - Fuyang Zhang Ling Zhang Guangyu Hu Xiyao Chen Hui Liu Congye Li Xiong Guo Chong Huang Fangfang Sun Tongzheng Li Zhe Cui Yongzhen Guo Wenjun Yan Yunlong Xia Zhiyuan Liu Zhen Lin Weixun Duan Linhe Lu Xinyi Wang Zhengyang Wang Shan Wang Ling Tao Departments of Cardiology (F.Z., L.Z., G.H., H.L., C.L., X.G., C.H., F.S., T.L., Z.C., Y.G., W.Y., Y.X., Z. Liu, Z. Lin, X.W., Z.W., S.W., L.T.), Xijing Hospital, Fourth Military Medical University, Xi’an, China. Geriatrics (X.C.), Xijing Hospital, Fourth Military Medical University, Xi’an, China. Cardiovascular Surgery (W.D., L.L.), Xijing Hospital, (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Myocardial mitochondrial dysfunction underpins the pathogenesis of heart failure (HF), yet therapeutic options to restore myocardial mitochondrial function are scarce. Epigenetic modifications of mitochondrial DNA (mtDNA), such as methylation, play a (…) (Circulation)
• 11:00
  Atherosclerosis Is a Smooth Muscle Cell–Driven Tumor-Like Disease - Huize Pan Sebastian E. Ho Chenyi Xue Jian Cui Quinian S. Johanson Nadja Sachs Leila S. Ross Fang Li Robert A. Solomon E. Sander Connolly Virendra I. Patel Lars Maegdefessel Hanrui Zhang Muredach P. Reilly Division of Cardiology, Department of Medicine (H.P., S.E.H., C.X., J.C., Q.S.J., L.S.R., F.L., H.Z., M.P.R.), Columbia University Irving Medical Center, New York, NY. Irving Institute for Clinical and Translational Research (M.P.R.), Columbia University Irving Medical Center, New York, NY. Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, (…) Circulation
  Circulation, Volume 149, Issue 24, Page 1885-1898, June 11, 2024. BACKGROUND:Atherosclerosis, a leading cause of cardiovascular disease, involves the pathological activation of various cell types, including immunocytes (eg, macrophages and T cells), smooth muscle cells (SMCs), and endothelial (…) (Circulation)

29 avril

Circulation http://ahajournals.org/

• 11:00
  PDZ-Binding Kinase, a Novel Regulator of Vascular Remodeling in Pulmonary Arterial Hypertension - Zsuzsanna Bordan Robert Batori Stephen Haigh Xueyi Li Mary Louise Meadows Zach L. Brown Madison A. West Kunzhe Dong Weihong Han Yunchao Su Qian Ma Yuqing Huo Jiliang Zhou Mahmoud Abdelbary Jennifer Sullivan Neal. L. Weintraub David W. Stepp Feng Chen Scott A. Barman David J.R. Fulton Vascular Biology Center, Medical College of Georgia, Augusta University. (Z.B., R.B., S.H., Z.L.B., M.A.W., Q.M., Y.H., N.L.W., D.W.S., D.J.R.F.) Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University. (M.L.M., W.H., Y.S., J.Z., S.A.B., D.J.R.F.) Immunology Center of Georgia, (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Pulmonary arterial hypertension (PAH) is high blood pressure in the lungs that originates from structural changes in small resistance arteries. A defining feature of PAH is the inappropriate remodeling of pulmonary arteries (PA) leading to right ventricle (…) (Circulation)
• 11:00
  ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels - Yang Lin Chang-Hyun Gil Kimihiko Banno Masataka Yokoyama Matthew Wingo Ellen Go Nutan Prasain Ying Liu Takashi Hato Hisamichi Naito Taku Wakabayashi Musia Sominskaia Meng Gao Kevin Chen Fuqiang Geng Jesus Maria Gomez Salinero Sisi Chen W. Christopher Shelley Momoko Yoshimoto Sergio Li Calzi Michael P. Murphy Kyoji Horie Maria B. Grant Ryan Schreiner David Redmond David P. Basile Shahin Rafii Mervin C. Yoder Division of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY. (Y. (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Most organs are maintained lifelong by resident stem/progenitor cells. During development and regeneration, lineage-specific stem/progenitor cells can contribute to the growth or maintenance of different organs, whereas fully differentiated mature cells (…) (Circulation)
• 11:00
  CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT - Zeina R. Al Sayed Céline Pereira Rémi Le Borgne Christine Viaris de Lesegno Charlène Jouve Esthel Pénard Adeline Mallet Nihar Masurkar Gildas Loussouarn Jean-Marc Verbavatz Christophe Lamaze David-Alexandre Trégouët Jean-Sébastien Hulot PARCC, INSERM, Université Paris Cité, Paris, France. (Z.R.A.S., C.P., C.J., N.M., J.-S.H.) Institut Jacques Monod, CNRS, Université Paris Cité, Paris, France. (R.L.B., J.-M.V.) Ultrastructural BioImaging Core Facility (UBI), C2RT, Institut Pasteur, Université Paris Cité, Paris, France. (E.P., A.M.) INSERM U1143, CNRS UMR 3666, PSL Research University, (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Drug-induced QT prolongation (diLQT) is a feared side effect that could expose susceptible individuals to fatal arrhythmias. The occurrence of diLQT is primarily attributed to unintended drug interactions with cardiac ion channels, notably the hERG (human (…) (Circulation)
• 08:00
  Empowering Valvular Heart Disease Research With Stem Cell–Derived Valve Cells - Mengcheng Shen Joseph C. Wu Stanford Cardiovascular Institute (M.S., J.C.W.), Stanford University, CA. Departments of Medicine, Division of Cardiology (M.S., J.C.W.), Stanford University, CA. Radiology (J.C.W.), Stanford University, CA. Circulation
  Circulation, Volume 149, Issue 18, Page 1457-1460, April 30, 2024. (Circulation)
• 08:00
  Letter by Apostolos et al Regarding Article, “Computed Tomography Cardiac Angiography Before Invasive Coronary Angiography in Patients With Previous Bypass Surgery: The BYPASS-CTCA Trial” - Anastasios Apostolos Grigoris V. Karamasis Grigorios Tsigkas First Department of Cardiology (A.A.), Medical School, National and Kapodistrian University of Athens, Hippokration General Hospital, Greece. Second Department of Cardiology (G.V.K.), Medical School, National and Kapodistrian University of Athens, Hippokration General Hospital, Greece. Department of Cardiology, University Hospital of Patras, Greece (G.T.). Circulation
  Circulation, Volume 149, Issue 18, Page e1132-e1132, April 30, 2024. (Circulation)
• 08:00
  Response by Kelham et al to Letter Regarding Article, “Computed Tomography Cardiac Angiography Before Invasive Coronary Angiography in Patients With Previous Bypass Surgery: The BYPASS-CTCA Trial” - Matthew Kelham Anthony Mathur Daniel A. Jones Centre for Cardiovascular Medicine and Devices, Faculty of Medicine & Dentistry (M.K., A.M., D.A.J.) NIHR Barts Biomedical Research Centre, Barts Heart Centre and William Harvey Research Institute (M.K., A.M., D.A.J.) Barts Cardiovascular Clinical Trials Unit, Faculty of Medicine & Dentistry (D.A.J.) Queen Mary University of London. Barts Interventional Group, Barts Heart Centre, Barts Health NHS Trust, London (M.K., A.M., D.A.J.). Circulation
  Circulation, Volume 149, Issue 18, Page e1133-e1133, April 30, 2024. (Circulation)
• 08:00
  Global Rounds: Cardiovascular Care in Australia and New Zealand - Sarah Zaman Nicola C. Edwards Derek P. Chew Westmead Applied Research Centre, Faculty of Medicine and Health, University of Sydney, Australia (S.Z.). Department of Cardiology, Westmead Hospital, Sydney, Australia (S.Z.). Department of Cardiology, Te Toka Tumai, Auckland, New Zealand (N.C.E.). Faculty of Medical and Health Sciences, University of Auckland, New Zealand (N.C.E.). Victorian Heart Institute, Monash University, Melbourne, Australia (D.P.C.). College of Medicine & Public Health, Flinders University of South Australia, Australia (D.P.C.). Circulation
  Circulation, Volume 149, Issue 18, Page 1402-1404, April 30, 2024. (Circulation)
• 08:00
  Adult Congenital Heart Disease - Mikael Dellborg Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. Adult Congenital Heart Unit, Department of Medicine/Medicine, Geriatrics, Acute care, Östra, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden. Circulation
  Circulation, Volume 149, Issue 18, Page 1397-1399, April 30, 2024. (Circulation)
• 08:00
  Fossil Fuels, Climate Change, and Cardiovascular Disease: A Call to Action - Caren G. Solomon Philip J. Landrigan Department of Medicine, Harvard Medical School, Boston, MA (C.G.S.). Department of Medicine, Brigham and Women’s Hospital, Boston, MA (C.G.S.). Program for Global Public Health & the Common Good, Boston College, Chestnut Hill, MA (P.J.L.). Centre Scientifique de Monaco (P.J.L.). Circulation
  Circulation, Volume 149, Issue 18, Page 1400-1401, April 30, 2024. (Circulation)
• 08:00
  Unraveling the Unsolved Mysteries of the Athletic Heart - William K. Cornwell Benjamin D. Levine Division of Cardiology, Department of Medicine, University of Colorado, Aurora (W.K.C.). Clinical Translational Research Center, University of Colorado Anschutz Medical Center, Aurora, CO (W.K.C.). Division of Cardiology, University of Texas Southwestern Medical Center, Dallas (B.D.L.). Texas Health Presbyterian Hospital, Institute for Exercise and Environmental Medicine, Dallas (B.D.L.). Circulation
  Circulation, Volume 149, Issue 18, Page 1416-1418, April 30, 2024. (Circulation)
• 08:00
  Peripheral Oxygenation and Pulmonary Hemodynamics in Individuals With Fontan Circulation During 24-Hour High-Altitude Exposure Simulation - Nicole Müller Julian Alexander Härtel Jan Schmitz Ute Baur Melanie von der Wiesche Iris Rieger Darius Gerlach Jon von Stritzky Anja Bach Christopher Hart Janina Bros Benedikt Seeger Emily Zollmann Marijke Grau Boris Dragutinovic Laura-Maria de Boni Jan-Niklas Hönemann Wilhelm Bloch Daniel Aeschbach Eva-Maria Elmenhorst Ulrike Herberg Alena Hess Moritz Schumann Tobias Kratz Jens Jordan Johannes Breuer Jens Tank Department of Pediatric Cardiology (N.M., J.A.H., U.B., C.H., A.H., T.K., J.B.), University of Bonn Medical Center, Germany. Institute of Experimental Epileptology and Cognition (…) Circulation
  Circulation, Volume 149, Issue 18, Page 1466-1468, April 30, 2024. (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 149, Issue 18, Page 1461-1465, April 30, 2024. (Circulation)

26 avril

Circulation http://ahajournals.org/

• 11:00
  Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell–Derived Cardiac Spheroids - Hideki Kobayashi Shugo Tohyama Hajime Ichimura Noburo Ohashi Shuji Chino Yusuke Soma Hidenori Tani Yuki Tanaka Xiao Yang Naoko Shiba Shin Kadota Kotaro Haga Taijun Moriwaki Yuika Morita-Umei Tomohiko C. Umei Otoya Sekine Yoshikazu Kishino Hideaki Kanazawa Hiroyuki Kawagishi Mitsuhiko Yamada Kazumasa Narita Takafumi Naito Tatsuichiro Seto Koichiro Kuwahara Yuji Shiba Keiichi Fukuda Department of Cardiovascular Medicine (H. Kobayashi, K.K.), Shinshu University, Matsumoto, Japan. Division of Cardiovascular Surgery, Department of Surgery (H.I., N.O., S.C., Y.T., T.S.), Shinshu University, (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:The clinical application of human induced pluripotent stem cell–derived cardiomyocytes (CMs) for cardiac repair commenced with the epicardial delivery of engineered cardiac tissue; however, the feasibility of the direct delivery of human induced (…) (Circulation)

25 avril

Circulation http://ahajournals.org/

• 11:00
  SPTLC3 Is Essential for Complex I Activity and Contributes to Ischemic Cardiomyopathy - Anna Kovilakath Adolfo G. Mauro Yolander Valentine Frank Raucci Maryam Jamil Christiane Carter Jeremy Thompson Qun Chen Beutner Gisela Yang Yue Jeremy Allegood Xiaoxin X. Wang Jordan Dail Teja Devarakonda Komuraiah Myakala Jolene J. Windle Mark A. Subler David Montefusco Belinda Willard Ali Javaheri Tytus Bernas Sushil K. Mahata Moshe Levi Jinze Liu George A. Porter Edward J. Lesnefsky Fadi N. Salloum L. Ashley Cowart Department of Human and Molecular Genetics (A.K., M.J., J.J.W., M.A.S.), Virginia Commonwealth University, Richmond. C. Kenneth and Dianne Wright Center for Clinical and (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Dysregulated metabolism of bioactive sphingolipids, including ceramides and sphingosine-1-phosphate, has been implicated in cardiovascular disease, although the specific species, disease contexts, and cellular roles are not completely understood. (…) (Circulation)
• 11:00
  The Tricuspid Valve: A Review of Pathology, Imaging, and Current Treatment Options: A Scientific Statement From the American Heart Association - Laura J. Davidson Gilbert H.L. Tang Edwin C. Ho Marat Fudim Tiberio Frisoli Anton Camaj Margaret T. Bowers Sofia Carolina Masri Pavan Atluri Joanna Chikwe Peter J. Mason Jason C. Kovacic George D. Dangas Circulation
  Circulation, Volume 149, Issue 22, Page e1223-e1238, May 28, 2024. Tricuspid valve disease is an often underrecognized clinical problem that is associated with significant morbidity and mortality. Unfortunately, patients will often present late in their disease course with severe right-sided (...) (Circulation)
• 11:00
  Comparison of Incidence and Prognostic Impact of Ischemic, Major Bleeding and Heart Failure Events in Patients With Chronic Coronary Syndrome: Insights From the CORONOR Registry - Gilles Lemesle Nicolas Lamblin Guillaume Schurtz Julien Labreuche Alain Duhamel Basile Verdier Philippe Gabriel Steg Christophe Bauters Heart and Lung Institute, University Hospital of Lille, France (G.L.). Université de Lille, France (G.L.). Institut Pasteur of Lille, Inserm U1011, Lille, France (G.L.). FACT (French Alliance for Cardiovascular Trials), Paris, France (G.L.). Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, France (N.L., C.B.). University Hospital of Lille, France (G.S., B.V.). Department of Biostatistics, CHU Lille, Lille, France (J.L., A.D.). Université (…) Circulation
  Circulation, Volume 149, Issue 22, Page 1708-1716, May 28, 2024. BACKGROUND:Evaluation of the residual risk in patient with chronic coronary syndrome is challenging in daily practice. Several types of events (myocardial infarction, ischemic stroke, bleeding, and heart failure [HF]) may occur, (...) (Circulation)

22 avril

Circulation http://ahajournals.org/

• 08:00
  Much Ado About Nothing? CABG or PCI for Left Main Coronary Artery Disease - Jay Giri Tsuyoshi Kaneko Cardiovascular Medicine Division, Hospital of the University of Pennsylvania, Philadelphia (J.G.). Penn Cardiovascular Outcomes, Quality, & Evaluative Research Center, Leonard Davis Institute of Health Economics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (J.G.). Division of Cardiothoracic Surgery, Washington University in St Louis, MO (T.K.). Circulation
  Circulation, Volume 149, Issue 17, Page 1339-1340, April 23, 2024. (Circulation)
• 08:00
  Mediating Metabolism: Inhibition of Malic Enzyme 1 (ME1) Restores Endothelial Bioenergetics and Adenosine Signaling in Pulmonary Hypertension - Rashmi J. Rao Stephen Y. Chan Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, PA. Circulation
  Circulation, Volume 149, Issue 17, Page 1372-1374, April 23, 2024. (Circulation)
• 08:00
  Autonomic Dysfunction Linked to Inhibition of the Nav1.7 Sodium Channel - Christopher P. Regan Pierre Morissette Richard L. Kraus Erjia Wang Leticia Arrington Marissa Vavrek Jan de Hoon Marleen Depre Thomas Lodeweyck Ignace Demeyer Tine Laethem Aubrey Stoch Arie Struyk Nonclinical Drug Safety (C.P.R., P.M., E.W.), Merck & Co., Inc., West Point, PA. Neuroscience (R.L.K.), Merck & Co., Inc., West Point, PA. Pharmacokinetics, Pharmacodynamics and Drug Metabolism (L.A., M.V.), Merck & Co., Inc., West Point, PA. Center for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven; Belgium (J.d.H., M.D., T. Lodeweyck). Burn (…) Circulation
  Circulation, Volume 149, Issue 17, Page 1394-1396, April 23, 2024. (Circulation)
• 08:00
  Trends in Age, Sex, and Racial Differences in the Incidence of Infective Endocarditis in Florida and New York - Anderson Anuforo Ehimen Aneni Emmanuel Akintoye Nnabuchi Anikpezie Smit D. Patel Ayorinde Soipe Eloho Olojakpoke Devin Burke Julius Gene Latorre Priyank Khandelwal Seemant Chaturvedi Bruce Ovbiagele Fadar Oliver Otite Department of Internal Medicine, SUNY Upstate Medical University, Syracuse, NY (A.A., A.S., E.O.). Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (E. Aneni, E. Akintoye). Department of Population Medicine, University of Mississippi Medical Center, Jackson, (N.A.). Department of Neurosurgery, University of (…) Circulation
  Circulation, Volume 149, Issue 17, Page 1391-1393, April 23, 2024. (Circulation)
• 08:00
  Sifting for Gold in Terabytes of Data: Illuminating Cardiovascular Biology in the ‘Omics Age - Svati H. Shah Robert E. Gerszten Division of Cardiology, Department of Medicine, Duke Molecular Physiology Institute, and Duke Center for Precision Health, Duke University School of Medicine, Durham, NC (S.H.S.). Broad Institute of Harvard and MIT, Cambridge, MA (R.E.G.). Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (R.E.G.). Circulation
  Circulation, Volume 149, Issue 17, Page 1323-1325, April 23, 2024. (Circulation)
• 08:00
  Making House Calls - Laurence Sperling Division of Cardiology, Preventive Cardiology, Emory University School of Medicine, Atlanta, GA. Hubert Department of Global Health, Rollins School of Public Health at Emory University, Atlanta, GA. Circulation
  Circulation, Volume 149, Issue 17, Page 1326-1327, April 23, 2024. (Circulation)

18 avril

Circulation http://ahajournals.org/

• 11:00
  Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association - Richard K. Cheng Michelle M. Kittleson Craig J. Beavers David H. Birnie Ron Blankstein Paco E. Bravo Nisha A. Gilotra Marc A. Judson Kristen K. Patton Leonie Rose-Bovino Circulation
  Circulation, Volume 149, Issue 21, Page e1197-e1216, May 21, 2024. Cardiac sarcoidosis is an infiltrative cardiomyopathy that results from granulomatous inflammation of the myocardium and may present with high-grade conduction disease, ventricular arrhythmias, and right or left ventricular (...) (Circulation)

16 avril

Circulation http://ahajournals.org/

• 11:00
  Systolic Blood Pressure and Survival to Very Old Age: Results From the Women’s Health Initiative - Bernhard Haring Chris A. Andrews Kathleen Hovey Aladdin H. Shadyab Andrea LaCroix Lisa Warsinger Martin Milagros C. Rosal Lewis H. Kuller Elena Salmoirago-Blotcher Nazmus Saquib Patrick Koo Deepika Laddu Marcia L. Stefanick JoAnn E. Manson Sylvia Wassertheil-Smoller Michael J. LaMonte Department of Medicine III, Saarland University, Homburg, Germany (B.H.). Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (B.H., S.W.-S.). Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at (…) Circulation
  Circulation, Volume 149, Issue 20, Page 1568-1577, May 14, 2024. BACKGROUND:The relationship between systolic blood pressure (SBP) and longevity is not fully understood. We aimed to determine which SBP levels in women ?65 years of age with or without blood pressure medication were associated (...) (Circulation)

15 avril

Circulation http://ahajournals.org/

• 11:00
  Environmental Exposures and Pediatric Cardiology: A Scientific Statement From the American Heart Association - Justin P. Zachariah Pei-Ni Jone Andrew O. Agbaje Heather H. Ryan Leonardo Trasande Wei Perng Shohreh F. Farzan Circulation
  Circulation, Volume 149, Issue 20, Page e1165-e1175, May 14, 2024. Environmental toxicants and pollutants are causes of adverse health consequences, including well-established associations between environmental exposures and cardiovascular diseases. Environmental degradation is widely (...) (Circulation)

12 avril

Circulation http://ahajournals.org/

• 11:00
  Positive Vasoreactivity Testing in Pulmonary Arterial Hypertension: Therapeutic Consequences, Treatment Patterns, and Outcomes in the Modern Management Era - Felix Gerhardt Eva Fiessler Karen M. Olsson Moritz Z. Kayser Gabor Kovacs Henning Gall H. Ardeschir Ghofrani Roza Badr Eslam Irene M. Lang Nicola Benjamin Ekkehard Grünig Michael Halank Tobias J. Lange Silvia Ulrich Hanno Leuchte Matthias Held Hans Klose Ralf Ewert Heinrike Wilkens Carmen Pizarro Dirk Skowasch Max Wissmüller Martin Hellmich Horst Olschewski Marius M. Hoeper Stephan Rosenkranz Department of Cardiology, Heart Center at the University Hospital Cologne, Germany (F.G., E.F., M.W., S.R.). Cologne Cardiovascular Research Center, University of Cologne, Germany (F.G., E.F., M.W., (…) Circulation
  Circulation, Volume 149, Issue 20, Page 1549-1564, May 14, 2024. BACKGROUND:Among patients with pulmonary arterial hypertension (PAH), acute vasoreactivity testing during right heart catheterization may identify acute vasoresponders, for whom treatment with high-dose calcium channel blockers (...) (Circulation)

11 avril

Circulation http://ahajournals.org/

• 11:00
  Patient-Centered Adult Cardiovascular Care: A Scientific Statement From the American Heart Association - Michael J. Goldfarb Martha Abshire Saylor Biykem Bozkurt Jillianne Code Katherine E. Di Palo Angela Durante Kristin Flanary Ruth Masterson Creber Modele O. Ogunniyi Fatima Rodriguez Martha Gulati Circulation
  Circulation, Volume 149, Issue 20, Page e1176-e1188, May 14, 2024. Patient-centered care is gaining widespread acceptance by the medical and lay communities and is increasingly recognized as a goal of high-quality health care delivery. Patient-centered care is based on ethical principles and (...) (Circulation)

10 avril

Circulation http://ahajournals.org/

• 08:30
  A Prospective Randomized Trial of Direct Oral Anticoagulant Therapy with A Fully Magnetically Levitated LVAD: The DOT-HM3 Study - Ivan Netuka Zuzana Tucanova Peter Ivak Stanislav Gregor Dushan Michael Kolesar Tomas Marek Vojtech Melenovsky Jana Binova Zora Dorazilova Marketa Hegarova Martina Podolec Hynek Riha Jean M. Connors Mandeep R. Mehra Institute for Clinical and Experimental Medicine, Prague, Czech Republic Brigham and Women's Hospital and Harvard Medical School, Boston, MA Circulation
  Circulation, Ahead of Print. (Circulation)

8 avril

Circulation http://ahajournals.org/

• 14:30
  Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: The DEPOSITION Randomized Controlled Trial - André Lamy Dmitry A. Sirota Frederic Jacques Ahmad Poostizadeh Nicolas Noiseux Sergey Efremov Philippe Demers Boris Akselrod Chew Yin Wang Rakesh C. Arora Piotr Branny Shay P. McGuinness Craig D. Brown Hugues Jeanmart Qiang Zhao Haibo Zhang Emilie P. Belley-Côté Richard P. Whitlock Austin Browne Ingrid Copland Jessica Vincent Rutaba Khatun Kumar Balasubramanian Shrikant I. Bangdiwala Michael H. McGillion Alison E. Fox-Robichaud Jessica Spence Salim Yusuf P.J. Devereaux Population Health Research Institute, Hamilton, Canada; Department of Surgery, McMaster University, Hamilton, Canada E. (…) Circulation
  Circulation, Ahead of Print. Background: Although intravenous tranexamic acid is used in cardiac surgery to reduce bleeding and transfusion, topical tranexamic acid results in lower plasma concentrations compared to intravenous tranexamic acid, which may lower the risk of seizures. We aimed to (…) (Circulation)
• 05:00
  Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial - David E. Kandzari Michael A. Weber Atul Pathak James P. Zidar Manish Saxena Shukri W. David Roland E. Schmieder Adam J. Janas Christopher Langer Alexandre Persu Farrell O Mendelsohn Koen Ameloot Malcolm Foster Tim A. Fischell Helen Parise Felix Mahfoud Piedmont Heart Institute, Atlanta, GA (D.E.K.). Division of Cardiovascular Medicine, State University of New York (SUNY), New York (M.A.W.). Department of Cardiovascular Medicine, Princess Grace Hospital and ESH Hypertension Excellence Center, Monaco (A.P.). University of North Carolina (UNC), Rex Healthcare, Raleigh, NC (J.P.Z.). Barts (…) Circulation
  Circulation, Volume 149, Issue 24, Page 1875-1884, June 11, 2024. BACKGROUND:Renal denervation (RDN) has demonstrated clinically relevant reductions in blood pressure (BP) among individuals with uncontrolled hypertension despite lifestyle intervention and medications. The safety and (…) (Circulation)
• 11:00
  Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation - Yike Zhu Matthew Ackers-Johnson Muthu K. Shanmugam Leroy Sivappiragasam Pakkiri Chester Lee Drum Yanpu Chen Johnny Kim Wyatt G. Paltzer Ahmed I. Mahmoud Wilson Lek Wen Tan Mick Chang Jie Lee Jianming Jiang Danh Anh Tuan Luu Shi Ling Ng Peter Yi Qing Li Anhui Wang Rong Qi Gabriel Jing Xiang Ong Timothy Yu Ng Jody J. Haigh Zenia Tiang A. Mark Richards Roger S.Y. Foo Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore (Y.Z., M.A.-J., M.K.S., L.S.P., C.L.D., W.L.W.T., M.C.J.L., J.J., L.D.A.T., S.L.N., P.Y.Q.L. G.J.X.O., T.Y.N., Z.T., A.M.R., (…) Circulation
  Circulation, Volume 149, Issue 23, Page 1833-1851, June 4, 2024. BACKGROUND:Adult mammalian cardiomyocytes have limited proliferative capacity, but in specifically induced contexts they traverse through cell-cycle reentry, offering the potential for heart regeneration. Endogenous cardiomyocyte (...) (Circulation)

7 avril

Circulation http://ahajournals.org/

• 06:15
  Randomized Evaluation of a Remote Management Program to Improve Guideline-Directed Medical Therapy: The DRIVE Trial - Alexander J. Blood Lee-Shing Chang Shahzad Hassan Jacqueline Chasse Gretchen Stern Daniel Gabovitch David Zelle Caitlin Colling Samuel J. Aronson Christian Figueroa Emma Collins Ryan Ruggiero Emily Zacherle Joshua Noone Carey Robar Jorge Plutzky Thomas A. Gaziano Christopher P. Cannon Deborah J. Wexler Benjamin M. Scirica Accelerator for Clinical Transformation (A.J.B., S.H., J.C., G.S., D.G., D.Z., S.J.A., C.F., E.C., R.R., J.P., T.A.G., C.P.C., B.M.S.), Brigham and Women’s Hospital, Boston, MA. Divisions of Cardiovascular Medicine (A.J.B., S.H., J.C., J.P., T.A.G., C.P.C., B.M.S.), (…) Circulation
  Circulation, Volume 149, Issue 23, Page 1802-1811, June 4, 2024. BACKGROUND:Several SGLT2i (sodium-glucose transport protein 2 inhibitors) and GLP1-RA (glucagon-like peptide-1 receptor agonists) reduce cardiovascular events and improve kidney outcomes in patients with type 2 diabetes; however, (...) (Circulation)
• 04:15
  Sodium-Glucose Cotransporter-2 Inhibitors and Major Adverse Cardiovascular Outcomes: A SMART-C Collaborative Meta-Analysis - Siddharth M. Patel Yu Mi Kang KyungAh Im Brendon L. Neuen Stefan D. Anker Deepak L. Bhatt Javed Butler David Z.I. Cherney Brian L. Claggett Robert A. Fletcher William G. Herrington Silvio E. Inzucchi Meg J. Jardine Kenneth W. Mahaffey Darren K. McGuire John J.V. McMurray Bruce Neal Milton Packer Vlado Perkovic Scott D. Solomon Natalie Staplin Muthiah Vaduganathan Christoph Wanner David C. Wheeler Faiez Zannad Yujie Zhao Hiddo J.L. Heerspink Marc S. Sabatine Stephen D. Wiviott TIMI Study Group (S.M.P., Y.M.K., K.I., M.S.S., S.D.W.), Brigham and Women’s Hospital and Harvard Medical School, (…) Circulation
  Circulation, Volume 149, Issue 23, Page 1789-1801, June 4, 2024. BACKGROUND:Sodium-glucose cotransporter-2 inhibitors (SGLT2i) consistently improve heart failure and kidney-related outcomes; however, effects on major adverse cardiovascular events (MACE) across different patient populations are (...) (Circulation)
• 07:00
  Clinical Impact of Routine Assessment of Patient-Reported Health Status in Heart Failure Clinic: The PRO-HF Trial - Alexander T. Sandhu Jamie Calma Megan Skye Neil Kalwani Jimmy Zheng Jessica Schirmer Natasha Din Cati Brown Johnson Anshal Gupta Roy Lan Brian Yu John A. Spertus Paul A. Heidenreich Division of Cardiovascular Medicine (A.T.S., J.C., M.S., N.K., J.S., P.A.H.), Stanford University, CA. Stanford Prevention Research Center (A.T.S.), Stanford University, CA. Department of Medicine (J.Z., C.B.J., A.G., R.L., B.Y.), Stanford University, CA. Palo Alto Veteran’s Affairs Healthcare System, CA (A.T.S., M.S., N.K., N.D., P.A.H.). University of Missouri–Kansas City Healthcare Institute for Innovations (…) Circulation
  Circulation, Volume 149, Issue 22, Page 1717-1728, May 28, 2024. BACKGROUND:The impact of routine clinic use of patient-reported outcome (PRO) measures on clinical outcomes in patients with heart failure (HF) has not been well-characterized. We tested if clinic-based use of a disease-specific (...) (Circulation)
• 14:00
  Effect of Gamification, Financial Incentives, or Both to Increase Physical Activity Among Patients at High Risk of Cardiovascular Events: The BE ACTIVE Randomized Controlled Trial - Alexander C. Fanaroff Mitesh S. Patel Neel Chokshi Samantha Coratti David Farraday Laurie Norton Charles Rareshide Jingsan Zhu Tamar Klaiman Julia E. Szymczak Louise B. Russell Dylan S. Small Kevin G.M. Volpp Department of Medicine, Perelman School of Medicine, (A.C.F., N.C., J.Z., T.K., K.G.M.V.), University of Pennsylvania, Philadelphia. Penn Cardiovascular Outcomes, Quality, and Evaluative Research Center (A.C.F.), University of Pennsylvania, Philadelphia. Penn Center for Health Incentives and Behavioral Economics (AC.F., S.C., D.F., L.N., C.R., J.Z., T.K., L.B.R., K.G.M.V.), University (…) Circulation
  Circulation, Volume 149, Issue 21, Page 1639-1649, May 21, 2024. BACKGROUND:Physical activity is associated with a lower risk of major adverse cardiovascular events, but few individuals achieve guideline-recommended levels of physical activity. Strategies informed by behavioral economics (...) (Circulation)

6 avril

Circulation http://ahajournals.org/

• 03:45
  Impact of Bempedoic Acid on Cardiovascular Outcomes by Sex - Leslie Cho Jorge Plutzky Danielle Brennan Michael J. Louie Lei Lei Paula Robinson Heather A. Powell Stephen J. Nicholls A. Michael Lincoff Steven E. Nissen Cleveland Clinic, Cleveland, OH (L.C., D.B., A.M.L., S.E.N.). Brigham and Women’s Hospital, Boston, MA (J.P.). Esperion Therapeutics, Inc, Ann Arbor, MI (M.J.L., L.L., P.R., H.A.P.). Victorian Heart Institute, Monash University, Melbourne, VIC, Australia (S.J.N.). Circulation
  Circulation, Volume 149, Issue 22, Page 1775-1777, May 28, 2024. (Circulation)
• 03:30
  Effect of Empagliflozin on Heart Failure Outcomes After Acute Myocardial Infarction: Insights From the EMPACT-MI Trial - Adrian F. Hernandez Jacob A. Udell W. Schuyler Jones Stefan D. Anker Mark C. Petrie Josephine Harrington Michaela Mattheus Svenja Seide Isabella Zwiener Offer Amir M. Cecilia Bahit Johann Bauersachs Antoni Bayes-Genis Yundai Chen Vijay K. Chopra Gemma A. Figtree Junbo Ge Shaun G. Goodman Nina Gotcheva Shinya Goto Tomasz Gasior Waheed Jamal James L. Januzzi Myung Ho Jeong Yuri Lopatin Renato D. Lopes Béla Merkely Puja B. Parikh Alexander Parkhomenko Piotr Ponikowski Xavier Rossello Morten Schou Dragan Simic Philippe Gabriel Steg Joanna Szachniewicz Peter van der Meer Dragos Vinereanu (…) Circulation
  Circulation, Volume 149, Issue 21, Page 1627-1638, May 21, 2024. BACKGROUND:Empagliflozin reduces the risk of heart failure (HF) events in patients with type 2 diabetes at high cardiovascular risk, chronic kidney disease, or prevalent HF irrespective of ejection fraction. Whereas the EMPACT-MI (...) (Circulation)

3 avril

Circulation http://ahajournals.org/

• 11:00
  Implementation Science to Achieve Equity in Heart Failure Care: A Scientific Statement From the American Heart Association - Khadijah Breathett Sabra Lewsey Nicholas K. Brownell Kendra Enright Lorraine S. Evangelista Nasrien E. Ibrahim Jose Iturrizaga Daniel D. Matlock Modele O. Ogunniyi Madeline R. Sterling Harriette G.C. Van Spall Circulation
  Circulation, Volume 149, Issue 19, Page e1143-e1163, May 7, 2024. Guideline-directed medical therapies and guideline-directed nonpharmacological therapies improve quality of life and survival in patients with heart failure (HF), but eligible patients, particularly women and individuals from (...) (Circulation)

2 avril

Circulation http://ahajournals.org/

• 11:00
  Association Between Chest Compression Pause Duration and Survival After Pediatric In-Hospital Cardiac Arrest - Kasper G. Lauridsen Ryan W. Morgan Robert A. Berg Dana E. Niles Monica E. Kleinman Xuemei Zhang Heather Griffis Jimena Del Castillo Sophie Skellett Javier J. Lasa Tia T. Raymond Robert M. Sutton Vinay M. Nadkarni Research Center for Emergency Medicine, Aarhus University, Denmark (K.G.L.). Department of Anesthesiology and Critical Care Medicine, Randers Regional Hospital, Denmark (K.G.L.). Department of Anesthesiology and Critical Care Medicine, The Children’s Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine (K.G.L., R.W.M., R.A.B., D.E.N., R.M.S., (…) Circulation
  Circulation, Volume 149, Issue 19, Page 1493-1500, May 7, 2024. BACKGROUND:The association between chest compression (CC) pause duration and pediatric in-hospital cardiac arrest survival outcomes is unknown. The American Heart Association has recommended minimizing pauses in CC in children to (...) (Circulation)

1er avril

Circulation http://ahajournals.org/

• 11:00
  LXR? Promotes Abdominal Aortic Aneurysm Formation Through UHRF1 Epigenetic Modification of miR-26b-3p - Xiao Guo Jianmei Zhong Yichao Zhao Yanan Fu Ling-yue Sun Ancai Yuan Junling Liu Alex F. Chen Jun Pu Department of Cardiology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. (X.G., J.Z., Y.Z., Y.F., L.-y.S., A.Y., J.L., J.P.) Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China. (J.L.) Institute for Developmental and (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Abdominal aortic aneurysm (AAA) is a severe aortic disease without effective pharmacological approaches. The nuclear hormone receptor LXR? (liver X receptor ?), encoded by theNR1H3gene, serves as a critical transcriptional mediator linked to several (…) (Circulation)
• 11:00
  BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension - Hui Shen Ya Gao Dedong Ge Meng Tan Qing Yin Tong-You Wade Wei Fangzhou He Tzong-Yi Lee Zhongyan Li Yuqin Chen Qifeng Yang Zhangyu Liu Xinxin Li Zixuan Chen Yi Yang Zhengang Zhang Patricia A. Thistlethwaite Jian Wang Atul Malhotra Jason X.-J. Yuan John Y.-J. Shyy Kaizheng Gong Department of Cardiology, Affiliated Hospital of Yangzhou University, Institute of Cardiovascular Disease, Yangzhou Key Lab of Innovation Frontiers in CVD, China (H.S., Y.G., D.G., M.T., Q. Yin, Z.L., X.L., Z.C., Y.Y., Z.Z., Z.G.). Division of Cardiology, University of California, San Diego, La Jolla. (T.-Y.W.W., (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:An imbalance of antiproliferative BMP (bone morphogenetic protein) signaling and proliferative TGF-? (transforming growth factor-?) signaling is implicated in the development of pulmonary arterial hypertension (PAH). The posttranslational modification (eg, (…) (Circulation)
• 08:00
  Modernizing Cardiovascular Medicine Board Certification: Leveraging Innovation and Strengthening Continuous Competency and Professional Growth - Joseph C. Wu B. Hadley Wilson James C. Fang Jodie L. Hurwitz George D. Dangas President, American Heart Association (J.C.W.). President, American College of Cardiology (B.H.W.). President, Heart Failure Society of America (J.C.F.). President, Heart Rhythm Society (J.L.H.). President, Society for Cardiovascular Angiography and Interventions (G.D.D.). Circulation
  Circulation, Volume 149, Issue 21, Page e1191-e1193, May 21, 2024. (Circulation)

28 mars

Circulation http://ahajournals.org/

• 10:00
  Advancing Wearable Biosensors for Congenital Heart Disease: Patient and Clinician Perspectives: A Science Advisory From the American Heart Association - Animesh Tandon Jennifer N. Avari Silva Ami B. Bhatt Colin K. Drummond Allison C. Hill Amanda E. Paluch Sheradon Waits Jenny E. Zablah Kevin C. Harris Circulation
  Circulation, Volume 149, Issue 19, Page e1134-e1142, May 7, 2024. Wearable biosensors (wearables) enable continual, noninvasive physiologic and behavioral monitoring at home for those with pediatric or congenital heart disease. Wearables allow patients to access their personal data and monitor (...) (Circulation)

27 mars

Circulation http://ahajournals.org/

• 10:00
  Cardiovascular Effects of Oral Ketone Ester Treatment in Patients With Heart Failure With Reduced Ejection Fraction: A Randomized, Controlled, Double-Blind Trial - Kristoffer Berg-Hansen Nigopan Gopalasingam Kristian Hylleberg Christensen Bertil Ladefoged Mads Jønsson Andersen Steen Hvitfeldt Poulsen Barry A. Borlaug Roni Nielsen Niels Møller Henrik Wiggers Department of Cardiology (K.B.-H., N.G., K.H.C., B.L., M.J.A., S.H.P., R.N., H.W.), Aarhus University Hospital, Denmark. Department of Endocrinology and Metabolism (N.M.), Aarhus University Hospital, Denmark. Department of Clinical Medicine, Faculty of Health, Aarhus University, Denmark (K.B.-H., N.G., K.H.C., B.L., S.H.P., N.M., H.W.). Department of Cardiovascular Medicine, Mayo Clinic Hospital, (…) Circulation
  Circulation, Volume 149, Issue 19, Page 1474-1489, May 7, 2024. BACKGROUND:Heart failure triggers a shift in myocardial metabolic substrate utilization, favoring the ketone body 3-hydroxybutyrate as energy source. We hypothesized that 14-day treatment with ketone ester (KE) would improve (...) (Circulation)

20 mars

Circulation http://ahajournals.org/

• 10:00
  Virus-Induced Acute Respiratory Distress Syndrome Causes Cardiomyopathy Through Eliciting Inflammatory Responses in the Heart - Jana Grune Geetika Bajpai Pervin Tülin Ocak Eva Kaufmann Kyle Mentkowksi Steffen Pabel Nina Kumowski Fadi E. Pulous Kim A. Tran David Rohde Shuang Zhang Yoshiko Iwamoto Gregory R. Wojtkiewicz Claudio Vinegoni Ursula Green Filip K. Swirski James R. Stone Jochen K. Lennerz Maziar Divangahi Maarten Hulsmans Matthias Nahrendorf Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston. (J.G., G.B., P.T.O., K.M., S.P., N.K., F.E.P., D.R., S.Z., Y.I., G.R.W., C.V., M.H., M.N.) Department of Radiology, Massachusetts General Hospital and Harvard Medical School, (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Viral infections can cause acute respiratory distress syndrome (ARDS), systemic inflammation, and secondary cardiovascular complications. Lung macrophage subsets change during ARDS, but the role of heart macrophages in cardiac injury during viral ARDS (…) (Circulation)

15 mars

Circulation http://ahajournals.org/

• 10:00
  Small Extracellular Vesicles From Infarcted and Failing Heart Accelerate Tumor Growth - Tal Caller Itai Rotem Olga Shaihov-Teper Daria Lendengolts Yeshai Schary Ruty Shai Efrat Glick-Saar Dan Dominissini Menachem Motiei Idan Katzir Rachela Popovtzer Merav Nahmoud Alex Boomgarden Crislyn D’Souza-Schorey Nili Naftali-Shani Jonathan Leor Neufeld and Tamman Cardiovascular Research Institutes, School of Medicine, Tel Aviv University, Israel (T.C., I.R., O.S.-T., D.L., Y.S., R.S., M.N., N.N.-S., J.L.). Lev Leviev Cardiovascular and Thoracic Center (T.C., I.R., O.S.-T., D.L., Y.S., N.N.-S., J.L.), Sheba Medical Center, Tel Hashomer, Israel. Pediatric Hemato-Oncology, Edmond and (…) Circulation
  Circulation, Volume 149, Issue 22, Page 1729-1748, May 28, 2024. BACKGROUND:Myocardial infarction (MI) and heart failure are associated with an increased incidence of cancer. However, the mechanism is complex and unclear. Here, we aimed to test our hypothesis that cardiac small extracellular (...) (Circulation)

11 mars

Circulation http://ahajournals.org/

• 11:00
  Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Left Main Disease With and Without Diabetes: Findings From a Pooled Analysis of 4 Randomized Clinical Trials - Prakriti Gaba Joseph F. Sabik Sabina A. Murphy Andrea Bellavia Patrick T. O’Gara Peter K. Smith Patrick W. Serruys A. Pieter Kappetein Seung-Jung Park Duk-Woo Park Evald H. Christiansen Niels R. Holm Per H. Nielsen Marc S. Sabatine Gregg W. Stone Brian A. Bergmark TIMI Study Group, Brigham and Women’s Hospital, Boston, MA (P.G., S.A.M., A.B., M.S.S., B.A.B.). Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (P.G., S.A.M., A.B., P.T.O., M.S.S., B.A.B.). Department of Surgery, University Hospitals Cleveland Medical Center, OH (J.F.S.). (…) Circulation
  Circulation, Volume 149, Issue 17, Page 1328-1338, April 23, 2024. BACKGROUND:Diabetes may be associated with differential outcomes in patients undergoing left main coronary revascularization with percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). The aim of (...) (Circulation)

1er mars

Circulation http://ahajournals.org/

• 11:00
  MBNL1 Regulates Programmed Postnatal Switching Between Regenerative and Differentiated Cardiac States - Logan R.J. Bailey Darrian Bugg Isabella M. Reichardt C. Dessirée Ortaç Abigail Nagle Jagadambika Gunaje Amy Martinson Richard Johnson Michael J. MacCoss Tomoya Sakamoto Daniel P. Kelly Michael Regnier Jennifer Davis Laboratory Medicine and Pathology (L.R.J.B., D.B., C.D.O., J.G., A.M., J.D.), University of Washington, Seattle. Bioengineering (I.M.R., A.N., M.R., J.D.), University of Washington, Seattle. Molecular and Cellular Biology (L.R.J.B.), University of Washington, Seattle. Medical Scientist Training Program (L.R.J.B.), University of Washington, Seattle. Genome Sciences (R.J., (…) Circulation
  Circulation, Volume 149, Issue 23, Page 1812-1829, June 4, 2024. BACKGROUND:Discovering determinants of cardiomyocyte maturity is critical for deeply understanding the maintenance of differentiated states and potentially reawakening endogenous regenerative programs in adult mammalian hearts as (...) (Circulation)

23 février

Circulation http://ahajournals.org/

• 11:00
  Targeting NPM1 Epigenetically Promotes Postinfarction Cardiac Repair by Reprogramming Reparative Macrophage Metabolism - Sheng Zhang Yunkai Zhang Xuewen Duan Bo Wang Zhenzhen Zhan Shanghai Institute of Transplantation, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Z.Z., B.W.). Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China (S.Z., X.D., Z.Z.). Naval Medical Center, Naval Medical University, Shanghai, China (Y.Z.). Circulation
  Circulation, Volume 149, Issue 25, Page 1982-2001, June 18, 2024. BACKGROUND:Reparative macrophages play a crucial role in limiting excessive fibrosis and promoting cardiac repair after myocardial infarction (MI), highlighting the significance of enhancing their reparative phenotype for wound (…) (Circulation)

15 février

Circulation http://ahajournals.org/

• 11:00
  S-Nitrosylation of Septin2 Exacerbates Aortic Aneurysm and Dissection by Coupling the TIAM1-RAC1 Axis in Macrophages - Yan Zhang Hao Zhang Shuang Zhao Zhenhua Qi Yiwei He Xuhong Zhang Wencheng Wu Ke Yan Lulu Hu Shixiu Sun Xinlong Tang Qing Zhou Feng Chen Aihua Gu Liansheng Wang Zhiren Zhang Bo Yu Dongjin Wang Yi Han Liping Xie Yong Ji Key Laboratory of Cardiovascular and Cerebrovascular Medicine; Key Laboratory of Targeted Intervention of Cardiovascular Disease; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Jiangsu, China (Y.Z., H.Z., S.Z., Z.Q., Y.H., X.Z., W.W., K.Y., L.H., S.S., F.C., L.X., Y.J.). Gusu School, Nanjing Medical University, (…) Circulation
  Circulation, Volume 149, Issue 24, Page 1903-1920, June 11, 2024. BACKGROUND:S-Nitrosylation (SNO), a prototypic redox-based posttranslational modification, is involved in cardiovascular disease. Aortic aneurysm and dissection are high-risk cardiovascular diseases without an effective cure. The (…) (Circulation)
• 11:00
  Directed Differentiation of Human Induced Pluripotent Stem Cells to Heart Valve Cells - Ziwen Cai Miaomiao Zhu Li Xu Yue Wang Yin Xu Wai Yen Yim Hong Cao Ruikang Guo Xiang Qiu Ximiao He Jiawei Shi Weihua Qiao Nianguo Dong Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (Z.C., L.X., Y.X., W.Y.Y., H.C., R.G., X.Q, J.S., W.Q., N.D.). Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fuzhou, China (Z.C.). Department of Physiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.Z., (…) Circulation
  Circulation, Volume 149, Issue 18, Page 1435-1456, April 30, 2024. BACKGROUND:A main obstacle in current valvular heart disease research is the lack of high-quality homogeneous functional heart valve cells. Human induced pluripotent stem cells (hiPSCs)-derived heart valve cells may help with (...) (Circulation)
• 11:00
  Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation - Amy Erica Lin Aneesh C. Bapat Ling Xiao Abhishek Niroula Jiangchuan Ye Waihay J. Wong Mridul Agrawal Christopher J. Farady Andreas Boettcher Christopher B. Hergott Marie McConkey Patricio Flores-Bringas Veronica Shkolnik Alexander G. Bick David Milan Pradeep Natarajan Peter Libby Patrick T. Ellinor Benjamin L. Ebert Division of Cardiovascular Medicine, Department of Medicine (A.E.L., P.L.), Brigham and Women’s Hospital, Boston, MA. Department of Pathology (W.J.W., C.B.H.), Brigham and Women’s Hospital, Boston, MA. Department of Medical Oncology, Dana Farber Cancer Institute, Harvard (…) Circulation
  Circulation, Volume 149, Issue 18, Page 1419-1434, April 30, 2024. BACKGROUND:Clonal hematopoiesis of indeterminate potential (CHIP), a common age-associated phenomenon, associates with increased risk of both hematological malignancy and cardiovascular disease. Although CHIP is known to (...) (Circulation)

13 février

Circulation http://ahajournals.org/

• 11:00
  Carbonylation of Runx2 at K176 by 4-Hydroxynonenal Accelerates Vascular Calcification - Xiaoxuan Zhai Shengchuan Cao Jiali Wang Bao Qiao Xuehao Liu Rui Hua Menglin Zhao Shukun Sun Yu Han Shuo Wu Jiaojiao Pang Qiuhuan Yuan Bailu Wang Feng Xu Shujian Wei Yuguo Chen Department of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China (X.Z., S.C., J.W., B.Q., X.L., R.H., M.Z., S.S., Y.H., S.W., J.P., Q.Y., F.X., S.W., Y.C.). Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Qilu Hospital of Shandong University, Jinan, China (X.Z., S.C., J.W., (…) Circulation
  Circulation, Volume 149, Issue 22, Page 1752-1769, May 28, 2024. BACKGROUND:Vascular calcification, which is characterized by calcium deposition in arterial walls and the osteochondrogenic differentiation of vascular smooth muscle cells, is an actively regulated process that involves complex (...) (Circulation)

12 février

Circulation http://ahajournals.org/

• 11:00
  The Macrophage Landscape Across the Lifespan of a Human Cardiac Allograft - Xiao Li Diwakar Turaga Rich G. Li Chang-Ru Tsai Julianna N. Quinn Yi Zhao Ruby Wilson Katherine Carlson Jun Wang Joseph A. Spinner Edward J. Hickey Iki Adachi James F. Martin The Texas Heart Institute, Houston (X.L., R.G.L., Y.Z., R.W., J.F.M.). Department of Pediatrics (D.T., J.A.S.), Baylor College of Medicine, Houston, TX. Department of Integrative Physiology (C.-R.T., K.C., J.F.M.), Baylor College of Medicine, Houston, TX. Department of Surgery (E.J.H., I.A.), Baylor College of Medicine, Houston, TX. Center for Organ Repair and Renewal (J.F.M.), Baylor College of Medicine, Houston, TX. (…) Circulation
  Circulation, Volume 149, Issue 21, Page 1650-1666, May 21, 2024. BACKGROUND:Much of our knowledge of organ rejection after transplantation is derived from rodent models.METHODS:We used single-nucleus RNA sequencing to investigate the inflammatory myocardial microenvironment in human pediatric (...) (Circulation)

8 février

Circulation http://ahajournals.org/

• 11:00
  Phosphorylation-Regulated Dynamic Phase Separation of HIP-55 Protects Against Heart Failure - Yunqi Jiang Jinge Gu Xiaodou Niu Jiaojiao Hu Yongzhen Zhang Dan Li Yida Tang Cong Liu Zijian Li Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China. (Y.J., X.N., Y.Z., Y.T., Z.L.) Department of Pharmacy, Peking University Third Hospital, Beijing, China. (Z.L.) Beijing Key Laboratory of Cardiovascular Receptors Research, State Key Laboratory of Vascular Homeostasis and Remodeling, and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Peking University, Beijing, China (Y.J., X.N., Y.Z., Y.T., Z.L.). (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Heart failure (HF), which is the terminal stage of many cardiovascular diseases, is associated with low survival rates and a severe financial burden. The mechanisms, especially the molecular mechanism combined with new theories, underlying the pathogenesis (…) (Circulation)

5 février

Circulation http://ahajournals.org/

• 11:00
  A Galectin-9–Driven CD11chigh Decidual Macrophage Subset Suppresses Uterine Vascular Remodeling in Preeclampsia - Yanhong Li Yifei Sang Yunjian Chang Chunfang Xu Yikong Lin Yao Zhang Philip C.N. Chiu William S.B. Yeung Haisheng Zhou Ningzheng Dong Ling Xu Jiajia Chen Weijie Zhao Lu Liu Di Yu Xingxing Zang Jiangfeng Ye Jinying Yang Qingyu Wu Dajin Li Ligang Wu Meirong Du Laboratory of Reproduction Immunology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University Shanghai Medical College, China (Y. Li, Y.S., C.X., Y. Lin, L.X., J.C., W.Z., L.L., D.L., M.D.). Department of Obstetrics, Longgang District Maternity and Child (…) Circulation
  Circulation, Volume 149, Issue 21, Page 1670-1688, May 21, 2024. BACKGROUND:Preeclampsia is a serious disease of pregnancy that lacks early diagnosis methods or effective treatment, except delivery. Dysregulated uterine immune cells and spiral arteries are implicated in preeclampsia, but the (...) (Circulation)
• 11:00
  Inactivation of Malic Enzyme 1 in Endothelial Cells Alleviates Pulmonary Hypertension - Ya Luo Xianmei Qi Zhenxi Zhang Jiawei Zhang Bolun Li Ting Shu Xiaona Li Huiyuan Hu Jinqiu Li Qihao Tang Yitian Zhou Mingyao Wang Tianfei Fan Wenjun Guo Ying Liu Jin Zhang Junling Pang Peiran Yang Ran Gao Wenhui Chen Chen Yan Yanjiang Xing Wenjing Du Jing Wang Chen Wang State Key Laboratory of Respiratory Health and Multimorbidity (Y.L., X.Q., J.Z., B.L., T.S., X.L., H.H., J.L., Q.T., Y.Z., J.P., P.Y., Y.X., J.W., C.W.) State Key Laboratory of Common Mechanism Research for Major Diseases (Z.Z., W.D.) Haihe Laboratory of Cell Ecosystem, Institute of Basic Medical Sciences, Chinese Academy of (…) Circulation
  Circulation, Volume 149, Issue 17, Page 1354-1371, April 23, 2024. BACKGROUND:Pulmonary hypertension (PH) is a progressive cardiopulmonary disease with a high mortality rate. Although growing evidence has revealed the importance of dysregulated energetic metabolism in the pathogenesis of PH, (...) (Circulation)

23 janvier

Circulation http://ahajournals.org/

• 11:00
  AVCAPIR: A Novel Procalcific PIWI-Interacting RNA in Calcific Aortic Valve Disease - Dong Han Tingwen Zhou Lifu Li Yan Ma Shiqi Chen Chunguang Yang Ning Ma Moshi Song Shaoshao Zhang Jie Wu Feng Cao Yongjun Wang Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China (D.H., T.Z., S.C., C.Y., J.W., Y.W.). National Clinical Research Center for Geriatric Diseases, 2nd Medical Center, Chinese PLA General Hospital, Beijing, China (D.H., Y.M., F.C.). Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical (…) Circulation
  Circulation, Volume 149, Issue 20, Page 1578-1597, May 14, 2024. BACKGROUND:Calcification of the aortic valve leads to increased leaflet stiffness and consequently results in the development of calcific aortic valve disease (CAVD). However, the underlying molecular and cellular mechanisms of (...) (Circulation)

18 janvier

Circulation http://ahajournals.org/

• 11:00
  Piezo1-Mediated Neurogenic Inflammatory Cascade Exacerbates Ventricular Remodeling After Myocardial Infarction - Meiyan Sun Sui Mao Chao Wu Xiaoyong Zhao Chengxiao Guo Jun Hu Shijin Xu Fen Zheng Guoqing Zhu Hui Tao Shufang He Ji Hu Ye Zhang Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, China (M.S., S.M., C.W., C.G., J.H., S.X., H.T., S.H., Y.Z.). Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, China (M.S., S.M., C.W., C.G., J.H., S.X., H.T., S.H., Y.Z.). Laboratory of Stress Neurobiology, School of Life Science and Technology, ShanghaiTech (…) Circulation
  Circulation, Volume 149, Issue 19, Page 1516-1533, May 7, 2024. BACKGROUND:Heart failure is associated with a high rate of mortality and morbidity, and ventricular remodeling invariably precedes heart failure. Ventricular remodeling is fundamentally driven by mechanotransduction that is (...) (Circulation)
• 11:00
  Novel Role for Cardiolipin as a Target of Therapy to Mitigate Myocardial Injury Caused by Venoarterial Extracorporeal Membrane Oxygenation - Lija Swain Shreyas Bhave Xiaoying Qiao Lara Reyelt Kay D. Everett Junya Awata Rahul Raghav Sarah N. Powers Genya Sunagawa Peter S. Natov Elena Mahmoudi Mary Warner Greg Couper Masashi Kawabori Satoshi Miyashita Tejasvi Aryaputra Gordon S. Huggins Michael T. Chin Navin K. Kapur Molecular Cardiology Research Institute, Interventional Research Laboratories, and The Cardiovascular Center, Tufts Medical Center. Circulation
  Circulation, Volume 149, Issue 17, Page 1341-1353, April 23, 2024. BACKGROUND:Cardiolipin is a mitochondrial-specific phospholipid that maintains integrity of the electron transport chain (ETC) and plays a central role in myocardial ischemia/reperfusion injury. Tafazzin is an enzyme that is (...) (Circulation)

15 janvier

Circulation http://ahajournals.org/

• 11:00
  Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1 - Tiffany A. Garbutt Zhenhua Wang Haofei Wang Hong Ma Hongmei Ruan Yanhan Dong Yifang Xie Lianmei Tan Ranan Phookan Joy A. Stouffer Vasanth Vedantham Yuchen Yang Li Qian Jiandong Liu Department of Pathology and Laboratory Medicine (T.A.G., Z.W., H.W., H.M., Y.D., Y.X., L.T., R.P., J.A.S., Y.Y., L.Q., J.L.), University of North Carolina, Chapel Hill. McAllister Heart Institute (T.A.G., Z.W., H.W., H.M., Y.D., Y.X., L.T., R.P., J.A.S., Y.Y., L.Q., J.L.), University of North Carolina, Chapel Hill. Now with: Department of Cardiology, 2nd Affiliated Hospital, School of Medicine, Zhejiang (…) Circulation
  Circulation, Volume 149, Issue 19, Page 1501-1515, May 7, 2024. BACKGROUND:During the neonatal stage, the cardiomyocyte undergoes a constellation of molecular, cytoarchitectural, and functional changes known collectively as cardiomyocyte maturation to increase myocardial contractility and (...) (Circulation)

12 janvier

Circulation http://ahajournals.org/

• 11:00
  ErbB3 Governs Endothelial Dysfunction in Hypoxia-Induced Pulmonary Hypertension - Jin-Song Bian Jingyu Chen Junting Zhang Jianxin Tan Yuan Chen Xusheng Yang Yiying Li Lin Deng Rongchang Chen Xiaowei Nie Key Laboratory of Shenzhen Respiratory Disease, Shenzhen Institute of Respiratory Disease, Shenzhen People’s Hospital (the First Affiliated Hospital, Southern University of Science and Technology; the Second Clinical Medical College, Jinan University), China (J.-S.B., J.Z., Y.L., R.C., X.N.). Department of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Pulmonary hypertension, characterized by vascular remodeling, currently lacks curative therapeutic options. The dysfunction of pulmonary artery endothelial cells plays a pivotal role in the initiation and progression of pulmonary hypertension (PH). ErbB3 (…) (Circulation)
• 11:00
  Ptpn23 Controls Cardiac T-Tubule Patterning by Promoting the Assembly of Dystrophin-Glycoprotein Complex - Chen Xu Ge Zhang Xinjian Wang Xiaozhi Huang Jiayin Zhang Shuxian Han Jinxi Wang Duane D. Hall Ruoqing Xu Feng He Xing Chang Fudi Wang Wenjun Xie Zhichao Wu Long-Sheng Song Peidong Han Center for Genetic Medicine, The Fourth Affiliated Hospital (C.X., G.Z., X.W., X.H., J.Z., S.H., R.X., F.H., P.H.), Zhejiang University School of Medicine, Hangzhou, China. School of Public Health, State Key Laboratory of Experimental Hematology (F.W.), Zhejiang University School of Medicine, Hangzhou, China. Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, China (C.X., (…) Circulation
  Circulation, Volume 149, Issue 17, Page 1375-1390, April 23, 2024. BACKGROUND:Cardiac transverse tubules (T-tubules) are anchored to sarcomeric Z-discs by costameres to establish a regular spaced pattern. One of the major components of costameres is the dystrophin-glycoprotein complex (DGC). (...) (Circulation)

21 décembre

Circulation http://ahajournals.org/

• 11:00
  Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction - Cristina Panico Arianna Felicetta Paolo Kunderfranco Marco Cremonesi Nicolò Salvarani Pierluigi Carullo Federico Colombo Alessandra Idini Mauro Passaretti Riccardo Doro Marcello Rubino Alessandro Villaschi Giorgio Da Rin Clelia Peano Marinos Kallikourdis Carolina M. Greco Gianluigi Condorelli Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy (C. Panico, A.F., P.K., M.C., N.S., A.I., M.P., R,D., A.V., M.K., C.M.G., G.C.) IRCCS Humanitas Research Hospital, Rozzano (MI), Italy (C. Panico, A.F., M.C., N.S., F.C., A.I., M.P., R,D., M.R., A.V., G.D.R., M.K., (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Metabolic distress is often associated with heart failure with preserved ejection fraction (HFpEF) and represents a therapeutic challenge. Metabolism-induced systemic inflammation links comorbidities with HFpEF. How metabolic changes affect myocardial (…) (Circulation)

18 décembre

Circulation http://ahajournals.org/

• 08:55
  Reduced Ejection Fraction in Elite Endurance Athletes: Clinical and Genetic Overlap With Dilated Cardiomyopathy - Guido Claessen Ruben De Bosscher Kristel Janssens Paul Young Christophe Dausin Mathias Claeys Piet Claus Kaatje Goetschalckx Jan Bogaert Amy M. Mitchell Michael D. Flannery Adrian D. Elliott Chenglong Yu Olivier Ghekiere Tomas Robyns Caroline M. Van De Heyning Prashanthan Sanders Jonathan M. Kalman Monique Ohanian Magdalena Soka Emma Rath Eleni Giannoulatou Renee Johnson Paul Lacaze Lieven Herbots Rik Willems Diane Fatkin Hein Heidbuchel André La Gerche Faculty of Medicine and Life Sciences, Limburg Clinical Research Center (LCRC), Hasselt University, Biomedical Research Institute, (…) Circulation
  Circulation, Volume 149, Issue 18, Page 1405-1415, April 30, 2024. BACKGROUND:Exercise-induced cardiac remodeling can be profound, resulting in clinical overlap with dilated cardiomyopathy, yet the significance of reduced ejection fraction (EF) in athletes is unclear. The aim is to assess the (...) (Circulation)

11 novembre

Circulation http://ahajournals.org/

• 10:15
  A Complex Anterior Mediastinal Mass in a Young Adult - Giselle Alexandra Suero-Abreu Lily Sung Anushri Parakh Brian Ghoshhajra Tomas G. Neilan Doreen DeFaria Yeh Yin P. Hung Danielle B. Cameron Jordan P. Bloom Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Division of Cardiovascular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA Division of Cardiovascular Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Department of Radiology, University of California San Diego, San (…) Circulation
  Circulation, Ahead of Print. (Circulation)

6 novembre

Circulation http://ahajournals.org/

• 11:00
  A Diagnostic CopyCat: Culture-Negative Infective Endocarditis of a Bioprosthetic Valve Presenting as ANCA Vasculitis - David E. Hamilton Sandro K. Cinti Cathryn J. Lapedis Kim A. Eagle University of Michigan Department of Internal Medicine, Division of Cardiovascular Medicine, Ann Arbor, MI University of Michigan Department of Pathology & Clinical Labs, Ann Arbor, MI; Veterans Affairs Ann Arbor Health Care System, Ann Arbor, MI Circulation
  Circulation, Ahead of Print. (Circulation)
• 11:00
  A Tale of Two Maladies: An Interplay of Mendelian Principles - Reynaldo H. Sanchez Veena Rajaram Nicholas S. Hendren Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX; Parkland Health System, Dallas, TX Circulation
  Circulation, Ahead of Print. (Circulation)