210 articles
1er juin
17 mai
13 mai
1er mai
17 avril
11 avril
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07:00
Association of Inflammatory Bowel Disease with Incident IgA Nephropathy -
Nakayama, Takashin; Kaneko, Hidehiro; Okada, Akira; Suzuki, Yuta; Fujiu, Katsuhito; Takeda, Norifumi; Morita, Hiroyuki; Takeda, Norihiko; Fukui, Akira; Yokoo, Takashi; Yasunaga, Hideo; Nangaku, Masaomi; Hayashi, Kaori
Clin J Am Soc Nephrol
Key Points We analyzed a nationwide epidemiologic cohort including approximately 4,000,000 individuals.We found a potential association of inflammatory bowel disease with a greater risk of developing IgA nephropathy. Background There have been scarce epidemiologic data on the relationship (…) -- Original Article: Clinical Nephrology
1er avril
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26 mars
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06:00
Key Points Nonlupus full house nephropathy is a rare, complex entity: confusion arises by the low-quality evidence and the lack of consensus on nomenclature.This systematic review supports that systemic lupus erythematosus and nonlupus full house nephropathy are distinct clinical entities, with (…) -- Original Article: Glomerular and Tubulointerstitial Diseases
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Associations between Different Antivirals and Hospital-Acquired Acute Kidney Injury in Adults with Herpes Zoster -
Xu, Ruqi; Gao, Qi; Zhang, Yuping; Lin, Yuxin; Li, Yanqin; Su, Licong; Zhou, Shiyu; Cao, Yue; Gao, Peiyan; Li, Pingping; Luo, Fan; Chen, Ruixuan; Zhang, Xiaodong; Nie, Sheng; Xu, Xin; the CRDS study Investigators
Clin J Am Soc Nephrol
Key Points Among intravenous antivirals, acyclovir was associated with the highest risk of hospital-acquired AKI, followed by penciclovir/ganciclovir and foscarnet.The risk of hospital-acquired AKI was dose dependent for intravenous nucleoside analogs. Background To examine the association of (…) -- Original Article: Acute Kidney Injury and ICU Nephrology
21 mars
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06:00
Key Points There are multiple factors associated with high sensitization levels among kidney transplant candidates, which differ by candidate sex.Since the initiation of the kidney allocation system, candidates with higher sensitization have higher rates of deceased donor (…) -- Original Article: Transplantation
18 mars
1er mars
29 février
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07:00
Combined Serologic and Genetic Risk Score and Prognostication of Phospholipase A2 receptor-Associated Membranous Nephropathy -
Hu, Xiaofan; Xu, Jing; Wang, Wei; Liu, Lili; Jing, Yuanmeng; Gao, Chenni; Yu, Xialian; Li, Yi; Lin, Li; Tong, Jun; Weng, Qinjie; Pan, Xiaoxia; Zhang, Wen; Ren, Hong; Li, Guisen; Kiryluk, Krzysztof; Chen, Nan; Xie, Jingyuan
Clin J Am Soc Nephrol
Introduction The aim of this study was to test whether a combined risk score on the basis of genetic risk and serology can improve the prediction of kidney failure in phospholipase A2 receptor (PLA2R)-associated primary membranous nephropathy. Methods We performed a retrospective analysis of (...) -- Original Article: Clinical Nephrology
27 février
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07:00
Effect of Spironolactone on Kidney Function in Kidney Transplant Recipients (the SPIREN trial): A Randomized Placebo-Controlled Clinical Trial -
Mortensen, Line A.; Jespersen, Bente; Helligsoe, Anne Sophie L.; Tougaard, Birgitte; Cibulskyte-Ninkovic, Donata; Egfjord, Martin; Boesby, Lene; Marcussen, Niels; Madsen, Kirsten; Jensen, Boye L.; Petersen, Inge; Bistrup, Claus; Thiesson, Helle C.
Clin J Am Soc Nephrol
Key Points Spironolactone is safe for kidney transplant patients.Spironolactone reduces kidney function by an acute effect, whereafter it remains stable.Spironolactone does not affect the progression of interstitial fibrosis in protocol biopsies. Background Long-term kidney allograft survival is (…) -- Original Article: Transplantation
26 février
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07:00
Different Interdialytic Intervals and Cardiorespiratory Fitness in Patients Undergoing Hemodialysis -
Pella, Eva; Boulmpou, Aristi; Boutou, Afroditi; Theodorakopoulou, Marieta P.; Haddad, Nasra; Karpetas, Antonios; Giamalis, Panagiotis; Papagianni, Aikaterini; Papadopoulos, Christodoulos E.; Vassilikos, Vassilios; Sarafidis, Pantelis
Clin J Am Soc Nephrol
Key Points This is the first study exploring differences in cardiorespiratory fitness assessed with cardiopulmonary exercise testing between the 2-day and the 3-day interdialytic interval.The 3-day interdialytic interval was associated with further impaired cardiorespiratory fitness.This effect (…) -- Original Article: Dialysis
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07:00
Background The Mayo Imaging Classification was developed to predict the rate of disease progression in patients with autosomal dominant polycystic kidney disease. This study aimed to validate its ability to predict kidney outcomes in a large multicenter autosomal dominant polycystic kidney (...) -- Original Article: Cystic Kidney Disease
22 février
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07:00
Long-Term Outcomes after Conversion to a Belatacept-Based Immunosuppression in Kidney Transplant Recipients -
Divard, Gillian; Aubert, Olivier; Debiais-Deschamp, Charlotte; Raynaud, Marc; Goutaudier, Valentin; Sablik, Marta; Sayeg, Caroline; Legendre, Christophe; Obert, Julie; Anglicheau, Dany; Lefaucheur, Carmen; Loupy, Alexandre
Clin J Am Soc Nephrol
Background Conversion to a belatacept-based immunosuppression is currently used as a calcineurin inhibitor (CNI) avoidance strategy when the CNI-based standard-of-care immunosuppression is not tolerated after kidney transplantation. However, there is a lack of evidence on the long-term benefit (...) -- Original Article: Transplantation
19 février
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Key Points This is the largest analysis of incident automated peritoneal dialysis (PD) prescriptions conducted in the United States to date.There was limited variability of automated PD prescriptions across the first 4 months of therapy.PD prescriptions tailored to meet the dialysis needs and (…) -- Original Article: Dialysis
13 février
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Key Points Treatment to dialysate sodium 135 versus 138 mEq/L led to no difference in the rate of change in intradialytic hypotension, but symptoms were greater in the low arm.Use of a dialysate sodium concentration of 135 versus 138 mEq/L led to a small reduction in interdialytic weight gain, (…) -- Original Article: Dialysis
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12 février
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Background Urinary stone disease is a prevalent condition associated with a high recurrence risk. Preventive pharmacological therapy has been proposed to reduce recurrent stone episodes. However, limited evidence exists regarding its effectiveness, contributing to its underutilization by (...) -- Original Article: Clinical Nephrology
5 février
1er février
26 janvier
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07:00
Sotagliflozin and Kidney Outcomes, Kidney Function, and Albuminuria in Type 2 Diabetes and CKD: A Secondary Analysis of the SCORED Trial -
Sridhar, Vikas S.; Bhatt, Deepak L.; Odutayo, Ayodele; Szarek, Michael; Davies, Michael J.; Banks, Phillip; Pitt, Bertram; Steg, Ph. Gabriel; Cherney, David Z.I.
Clin J Am Soc Nephrol
Background In the initial analysis of the Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients with Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk (SCORED) trial, because of early trial termination and suspension of adjudication, reconciliation (...) -- Original Article: Chronic Kidney Disease
24 janvier
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07:00
Effects of Vitamin D3 Supplementation on Incident Fractures by eGFR in VITAL -
Hsu, Simon; Zelnick, Leila R.; Buring, Julie E.; Chou, Sharon H.; Cook, Nancy R.; D'Agostino, Denise; Hoofnagle, Andrew N.; LeBoff, Meryl S.; Lee, I-Min; Limonte, Christine P.; Sesso, Howard D.; Manson, JoAnn E.; de Boer, Ian H.
Clin J Am Soc Nephrol
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07:00
Background Liddle syndrome was initially characterized by hypertension, hypokalemia, metabolic alkalosis, and suppressed plasma renin and aldosterone, resulting from gain-of-function variants in the epithelial Na+ channel (ENaC). Efficient treatment with ENaC inhibitors is available, but the (...) -- Original Article: Genetics
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23 janvier
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Background No previously validated patient-reported experience measures exist for use among patients undergoing home dialysis. We tested the Home Dialysis Care Experience survey, a newly developed 26-item experience measure, among patients from 30 dialysis facilities in the United States. (...) -- Original Article: Dialysis
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Role of Diuretics in Cardiovascular Events and Mortality in Systolic Blood Pressure Intervention Trial: A: Post Hoc: Analysis -
Bansal, Shweta; Boucher, Robert; Shen, Jincheng; Wei, Guo; Chertow, Glenn M.; Whelton, Paul K.; Cushman, William C.; Cheung, Alfred K.; Beddhu, Srinivasan; , on behalf of SPRINT
Clin J Am Soc Nephrol
Background In a post hoc analysis, we examined whether postrandomization diuretics use can explain and/or mediate the beneficial effects of intensive systolic BP lowering on cardiovascular disease and all-cause mortality in the Systolic Blood Pressure Intervention Trial (SPRINT). Methods (...) -- Original Article: Hypertension
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Histologic and Clinical Factors Associated with Kidney Outcomes in IgA Vasculitis Nephritis -
Barbour, Sean J.; Coppo, Rosanna; Er, Lee; Pillebout, Evangeline; Russo, Maria Luisa; Alpers, Charles E.; Fogo, Agnes B.; Ferrario, Franco; Jennette, J. Charles; Roberts, Ian S.D.; Cook, H. Terence; Ding, Jie; Su, Baige; Zhong, Xuhui; Fervenza, Fernando C.; Zand, Ladan; Peruzzi, Licia; Lucchetti, Laura; Katafuchi, Ritsuko; Shima, Yuko; Yoshikawa, Norishige; Ichikawa, Daisuke; Suzuki, Yusuke; Murer, Luisa; Wyatt, Robert J.; Park, Catherine; Nelson, Raoul D.; Narus, JoAnn H.; Wenderfer, Scott; Geetha, Duvuru; Daugas, Eric; Monteiro, Renato C.; Nakatani, Shinya; Mastrangelo, Antonio; (…)
Clin J Am Soc Nephrol
Background Nephritis is a common manifestation of IgA vasculitis and is morphologically indistinguishable from IgA nephropathy. While MEST-C scores are predictive of kidney outcomes in IgA nephropathy, their value in IgA vasculitis nephritis has not been investigated in large multiethnic (...) -- Original Article: Glomerular and Tubulointerstitial Diseases
15 janvier
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Phase 2 Trial of Cemdisiran in Adult Patients with IgA Nephropathy: A Randomized Controlled Trial -
Barratt, Jonathan; Liew, Adrian; Yeo, See Cheng; Fernström, Anders; Barbour, Sean J.; Sperati, C. John; Villanueva, Russell; Wu, Ming-Ju; Wang, Dazhe; Borodovsky, Anna; Badri, Prajakta; Yureneva, Elena; Bhan, Ishir; Cattran, Daniel; on behalf of the Cemdisiran Phase 2 Study Investigators and Collaborators
Clin J Am Soc Nephrol
Background IgA nephropathy is the most common primary GN. Clinical features of IgA nephropathy include proteinuria, which is the strongest known surrogate of progression to kidney failure. Complement pathway activation is a critical driver of inflammation and tissue injury in IgA nephropathy. (...) -- Original Article: Glomerular and Tubulointerstitial Diseases
12 janvier
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Hemoadsorption -
Bellomo, Rinaldo; Mehta, Ravindra L.; Forni, Lui G.; Zarbock, Alexander; Ostermann, Marlies; Ronco, Claudio; on behalf of the Acute Disease Quality Initiative Hemoadsorption Working Group
Clin J Am Soc Nephrol
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8 janvier
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Peritoneal dialysis (PD) is a form of KRT that offers flexibility and autonomy to patients with ESKD. It is associated with lower costs compared with hemodialysis in many countries. Unlike mechanical complications that typical arise early in the course of treatment, noninfectious, nonmechanical (…) -- Home Dialysis – Fundamentals and Beyond
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Peritoneal dialysis (PD) is a form of KRT that offers flexibility and autonomy to patients with ESKD. It is associated with lower costs compared with hemodialysis in many countries. However, it can be associated with unexpected interruptions to or discontinuation of therapy. Timely diagnosis and (…) -- Home Dialysis – Fundamentals and Beyond
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Background In 2022, the Accreditation Council for Graduate Medical Education reduced minimum program director protected time for program administration from 10 to 8 h/wk, with no core faculty requirement. We surveyed program leaders regarding the effect of these changes. Methods This is an (...) -- Original Article: Clinical Nephrology
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Background In most screening guidelines, high body mass index (BMI) is considered a contraindication for kidney donation. New insights suggest that central body fat distribution might provide greater power in assessing kidney risk. This study aimed to determine whether BMI and central body fat (...) -- Original Article: Transplantation
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07:00
Background Apolipoprotein L1 (ApoL1) variants G1 and G2 are associated with a higher risk of kidney disease. ApoL1 risk variants are predominantly seen in individuals with sub-Saharan African ancestry. In most transplant centers, potential organ donors are being selectively genetically tested (...) -- Original Article: Transplantation
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The Association of Intra-Abdominal Adhesions with Peritoneal Dialysis Catheter-Related Complications -
Qureshi, Mohammad Azfar; Maierean, Serban; Crabtree, John H.; Clarke, Alix; Armstrong, Sean; Fissell, Rachel; Jain, Arsh K.; Jassal, Sarbjit V.; Hu, Susie L.; Kennealey, Peter; Liebman, Scott; McCormick, Brendan; Momciu, Bogdan; Pauly, Robert P.; Pellegrino, Beth; Perl, Jeffrey; Pirkle, James L. Jr.; Plumb, Troy J.; Seshasai, Rebecca; Shah, Ankur; Shah, Nikhil; Shen, Jenny; Singh, Gurmukteshwar; Tennankore, Karthik; Uribarri, Jaime; Vasilevsky, Murray; Yang, Robert; Quinn, Robert R.; Nadler, Ashlie; Oliver, Matthew J.; on behalf of the North American Peritoneal Dialysis Registry
Clin J Am Soc Nephrol
Background This study investigated the association of intra-abdominal adhesions with the risk of peritoneal dialysis (PD) catheter complications. Methods Individuals undergoing laparoscopic PD catheter insertion were prospectively enrolled from eight centers in Canada and the United States. (...) -- Original Article: Maintenance Dialysis
4 janvier
3 janvier
1er janvier
27 décembre
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Management of Patients with Multidrug-Resistant Organisms in Outpatient Dialysis Facilities -
Dittrich, Mary; Silberzweig, Jeffrey; Hymes, Jeffrey L.; Giullian, Jeff; Green, Gopa; Wong, Leslie P.; Freedman, Barry I.; Bhat, J. Ganesh; Spry, Leslie; Taylor, Robert; Spech, Richard; Durvasula, Raghu; Blue, Sky R.
Clin J Am Soc Nephrol
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07:00
26 décembre
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Vaccine Effectiveness of BNT162b2 and CoronaVac against SARS-CoV-2 Omicron BA.2 in CKD -
Cheng, Franco Wing Tak; Yan, Vincent Ka Chun; Wan, Eric Yuk Fai; Chui, Celine Sze Ling; Lai, Francisco Tsz Tsun; Wong, Carlos King Ho; Li, Xue; Chan, Cheyenne I Ying; Wang, Boyuan; Tang, Sydney Chi Wai; Wong, Ian Chi Kei; Chan, Esther Wai Yin
Clin J Am Soc Nephrol
Background The ongoing coronavirus disease 2019 (COVID-19) pandemic has posed increased risks of hospitalization and mortality in patients with underlying CKD. Current data on vaccine effectiveness of COVID-19 vaccines are limited to patients with CKD on dialysis and seroconversion in the (...) -- Original Article: Chronic Kidney Disease
21 décembre
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Trust, Multidimensional Health Literacy, and Medication Adherence among Patients Undergoing Long-Term Hemodialysis -
Inanaga, Ryohei; Toida, Tatsunori; Aita, Tetsuro; Kanakubo, Yusuke; Ukai, Mamiko; Toishi, Takumi; Kawaji, Atsuro; Matsunami, Masatoshi; Okada, Tadao; Munakata, Yu; Suzuki, Tomo; Kurita, Noriaki
Clin J Am Soc Nephrol
Background Basic health literacy and trust in physicians can influence medication adherence in patients receiving dialysis. However, how high-order health literacy is associated with medication adherence and how trust in physicians mediates this association remain unclear. We assessed the (...) -- Original Article: Maintenance Dialysis
19 décembre
18 décembre
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Drug-Coated Balloon Angioplasty for Dysfunctional Arteriovenous Hemodialysis Fistulae: A Randomized Controlled Trial -
Zhao, Yiping; Wang, Pei; Wang, Yuzhu; Zhang, Lihong; Zhao, Yu; Li, Hua; He, Qiang; Liu, Hao; Luo, Jianfang; Jia, Xin; Yu, Zhengya; Guo, Wei; Zhang, Lan
Clin J Am Soc Nephrol
Background The aim of this study was to evaluate the efficacy and safety of paclitaxel-coated balloons (AcoArt Orchid) in treating dysfunctional arteriovenous fistulae. Methods The drug-eluting balloon for arteriovenous (AV) fistula in China trial was a prospective, multicenter, randomized (...) -- Original Article: Maintenance Dialysis
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Background In a phase 3 study of adults with active lupus nephritis, addition of voclosporin to mycophenolate mofetil (MMF) and low-dose glucocorticoids led to significant improvements in the proportion of participants achieving complete and partial renal response as well as sustained (...) -- Original Article: Glomerular and Tubulointerstitial Diseases
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14 décembre
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Associations of Angiopoietin 2 and Vascular Endothelial Growth Factor-A Concentrations with Clinical End Points -
Mohebi, Reza; Liu, Yuxi; Hansen, Michael K.; Yavin, Yshai; Sattar, Naveed; Pollock, Carol A.; Butler, Javed; Jardine, Meg; Masson, Serge; Heerspink, Hiddo J.L.; Januzzi, James L. Jr.
Clin J Am Soc Nephrol
Background Angiopoietin 2 regulates endothelial function partially mediated by vascular endothelial growth factor-A (VEGF-A) and may play a role in diabetic kidney disease (DKD). We assessed the association of angiopoietin 2 and VEGF-A with cardiorenal outcomes and investigated the effect of (...) -- Original Article: Chronic Kidney Disease
8 décembre
5 décembre
1er décembre
29 novembre
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07:00
Background Bone loss after kidney transplantation is highly variable. We investigated whether changes in bone turnover markers associate with bone loss during the first post-transplant year. Methods Bone mineral density (BMD) was measured at 0 and 12 months, with biointact parathyroid hormone, (...) -- Original Article: Mineral Metabolism
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Time-Varying Determinants of Graft Failure in Pediatric Kidney Transplantation in Europe -
Coens, Ferran; Knops, Noël; Tieken, Ineke; Vogelaar, Serge; Bender, Andreas; Kim, Jon Jin; Krupka, Kai; Pape, Lars; Raes, Ann; Tönshoff, Burkhard; Prytula, Agnieszka; CERTAIN Registry
Clin J Am Soc Nephrol
Background Little is known about the time-varying determinants of kidney graft failure in children. Methods We performed a retrospective study of primary pediatric kidney transplant recipients (younger than 18 years) from the Eurotransplant registry (1990–2020). Piece-wise exponential additive (...) -- Original Article: Transplantation
20 novembre
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Background Identification of reliable biomarkers to assess kidney fibrosis severity is necessary for patients with CKD. Activin A, a member of the TGF-? superfamily, has been suggested as a biomarker for kidney fibrosis. However, its precise utility in this regard remains to be established. (...) -- Original Article: Chronic Kidney Disease
17 novembre
16 novembre
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Background Intradialytic hypertension, defined as an increase in BP from pre- to post-hemodialysis (HD), affects 5%–15% of patients receiving maintenance HD and is associated with cardiovascular and all-cause mortality. Hypervolemia is believed to be a major etiological factor, yet the (...) -- Original Article: Maintenance Dialysis
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Background CKD has been implicated as a risk factor of venous thromboembolism, but the evidence is limited to relatively healthy populations. The objective of this study was to discern whether parameters of kidney function and damage are associated with the occurrence of venous thromboembolism (...) -- Original Article: Chronic Kidney Disease
14 novembre
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Background Cardiovascular diseases are an important cause of mortality in patients who have undergone kidney transplantation, but the knowledge on trends of cardiovascular mortality and specific causes of cardiovascular death among these patients is scarce. Methods Our aim was to compare the (...) -- Original Article: Transplantation
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Differential in Kidney Graft Years on the Basis of Solitary Kidney, Simultaneous Liver–Kidney, and Kidney-after-Liver Transplants -
Schold, Jesse D.; Mohan, Sumit; Jackson, Whitney E.; Stites, Erik; Burton, James R.; Bababekov, Yanik J.; Saben, Jessica L.; Pomposelli, James J.; Pomfret, Elizabeth A.; Kaplan, Bruce
Clin J Am Soc Nephrol
Background The number of simultaneous liver–kidney (SLK) transplants has significantly increased in the United States. There has also been an increase in kidney-after-liver transplants associated with 2017 policy revisions aimed to fairly allocate kidneys after livers. SLK and (...) -- Original Article: Transplantation
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Genome-Wide Polygenic Risk Score for CKD in Individuals with APOL1 High-Risk Genotypes -
Vy, Ha My T.; Coca, Steven G.; Sawant, Ashwin; Sakhuja, Ankit; Gutierrez, Orlando M.; Cooper, Richard; Loos, Ruth J.F.; Horowitz, Carol R.; Do, Ron; Nadkarni, Girish N.
Clin J Am Soc Nephrol
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How symptoms recorded in the electronic health record change during the transition to dialysis has not been fully explored. We used the Optum deidentified Integrated Claims–Clinical dataset to identify individuals with CKD stages 4 or 5 who transitioned to dialysis. We searched structured data (...) -- Insights from the USRDS
10 novembre
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Background Little is known about the prognostic significance of monoclonal gammopathy of undetermined and renal significance (MGUS and MGRS) in patients with CKD. The objective of this study was to determine the clinical and kidney outcomes of patients with CKD with either MGUS or MGRS (...) -- Original Article: Glomerular and Tubulointerstitial Diseases
9 novembre
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07:00
Background For persons with kidney failure, life participation is a critically important outcome, strongly linked to quality of life and mortality. To support patients' self-management abilities, three domains are typically emphasized: medical management, emotional management, and management (...) -- Original Article: Clinical Nephrology
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Background Reducing nonutilization of kidneys recovered from deceased donors is a current policy concern for kidney allocation in the United States. The likelihood of nonutilization is greater with a higher kidney donor risk index (KDRI) offer. We examine how opening offers for organs with (...) -- Original Article: Transplantation
7 novembre
6 novembre
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Strategies to Guide Preemptive Waitlisting and Equity in Waittime Accrual by Race/Ethnicity -
Ku, Elaine; Copeland, Timothy; Chen, Ling-Xin; Weir, Matthew R.; McCulloch, Charles E.; Johansen, Kirsten L.; Goussous, Naeem; Savant, Jonathan D.; Lopez, Isabelle; Amaral, Sandra
Clin J Am Soc Nephrol
Background Use of eGFR to determine preemptive waitlisting eligibility may contribute to racial/ethnic disparities in access to waitlisting, which can only occur when the eGFR falls to ?20 ml/min per 1.73 m2. Use of an alternative risk-based strategy for waitlisting may reduce these inequities (...) -- Original Article: Chronic Kidney Disease
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Regional Citrate Anticoagulation versus No Anticoagulation for CKRT in Patients with Liver Failure with Increased Bleeding Risk -
Bai, Ming; Yu, Yan; Zhao, Lijuan; Tian, Xiujuan; Zhou, Meilan; Jiao, Jing; Liu, Yi; Li, Yajuan; Yue, Yuan; Wei, Lei; Jing, Rui; Li, Yangping; Ma, Feng; Liang, Ying; Sun, Shiren
Clin J Am Soc Nephrol
Background The opinions on the efficacy and safety of no anticoagulation versus regional citrate anticoagulation for continuous KRT (CKRT) were controversial in patients with severe liver failure with a higher bleeding risk. We performed a randomized controlled trial to assess no (...) -- Original Article: Acute Kidney Injury and ICU Nephrology
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Background Depression is prevalent in patients with CKD and is related to poor prognosis. Despite the widespread use of antidepressants in the CKD population, their safety remains unclear. Methods We identified adults with CKD stages G3–5 (eGFR -- Original Article: Chronic Kidney Disease
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1er novembre
30 octobre
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The association between cardiac and kidney dysfunction has received attention over the past two decades. A putatively unique syndrome, the cardiorenal syndrome, distinguishing five subtypes on the basis of the chronology of cardiac and kidney events, has been widely adopted. This review (…) -- Review
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Background Volume overload is common in patients treated with peritoneal dialysis (PD) and is associated with poor clinical outcome. Steady concentration PD is where a continuous glucose infusion maintains the intraperitoneal glucose concentration and as a result provides continuous (...) -- Original Article: Maintenance Dialysis
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26 octobre
25 octobre
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Effect of Intensive Blood Pressure Control on Kidney Outcomes: Long-Term Electronic Health Record–Based Post-Trial Follow-Up of SPRINT -
Drawz, Paul E.; Lenoir, Kristin M.; Rai, Nayanjot Kaur; Rastogi, Anjay; Chu, Chi D.; Rahbari-Oskoui, Frederic F.; Whelton, Paul K.; Thomas, George; McWilliams, Andrew; Agarwal, Anil K.; Suarez, Maritza Marie; Dobre, Mirela; Powell, James; Rocco, Michael V.; Lash, James P.; Oparil, Suzanne; Raj, Dominic S.; Dwyer, Jamie P.; Rahman, Mahboob; Soman, Sandeep; Townsend, Raymond R.; Pemu, Priscilla; Horwitz, Edward; Ix, Joachim H.; Tuot, Delphine S.; Ishani, Areef; Pajewski, Nicholas M.
Clin J Am Soc Nephrol
Background Intensive BP lowering in the Systolic Blood Pressure Intervention Trial (SPRINT) produced acute decreases in kidney function and higher risk for AKI. We evaluated the effect of intensive BP lowering on long-term changes in kidney function using trial and outpatient electronic health (...) -- Original Article: Hypertension
23 octobre
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Participant Experience with Protocol Research Kidney Biopsies in the Kidney Precision Medicine Project -
Victoria-Castro, Angela M.; Corona-Villalobos, Celia P.; Xu, Alan Y.; Onul, Ingrid; Huynh, Courtney; Chen, Sarah W.; Ugwuowo, Ugochukwu; Sarkisova, Natalya; Dighe, Ashveena L.; Blank, Kristina N.; Blanc, Victoria M.; Rose, Michael P.; Himmelfarb, Jonathan; de Boer, Ian H.; Tuttle, Katherine R.; Roberts, Glenda V.; for the Kidney Precision Medicine Project
Clin J Am Soc Nephrol
Background Kidney biopsies are procedures commonly performed in clinical nephrology and are increasingly used in research. In this study, we aimed to evaluate the experiences of participants who underwent research kidney biopsies in the Kidney Precision Medicine Project (KPMP). Methods KPMP (...) -- Original Article: Clinical Nephrology
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Associations of Biomarkers of Tubular Injury and Inflammation with Biopsy Features in Type 1 Diabetes -
Limonte, Christine P.; Prince, David K.; Hoofnagle, Andrew N.; Galecki, Andrzej; Hirsch, Irl B.; Tian, Frances; Waikar, Sushrut S.; Looker, Helen C.; Nelson, Robert G.; Doria, Alessandro; Mauer, Michael; Kestenbaum, Bryan R.; de Boer, Ian H.
Clin J Am Soc Nephrol
Background Whether biomarkers of tubular injury and inflammation indicate subclinical structural kidney pathology early in type 1 diabetes remains unknown. Methods We investigated associations of biomarkers of tubular injury and inflammation with kidney structural features in 244 adults with (...) -- Original Article: Diabetes and the Kidney
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Circulating Metabolomic Associations with Neurocognitive Outcomes in Pediatric CKD -
Lee, Arthur M.; Xu, Yunwen; Hooper, Stephen R.; Abraham, Alison G.; Hu, Jian; Xiao, Rui; Matheson, Matthew B.; Brunson, Celina; Rhee, Eugene P.; Coresh, Josef; Vasan, Ramachandran S.; Schrauben, Sarah; Kimmel, Paul L.; Warady, Bradley A.; Furth, Susan L.; Hartung, Erum A.; Denburg, Michelle R.; on behalf of the CKD Biomarkers Consortium
Clin J Am Soc Nephrol
Background Children with CKD are at risk for impaired neurocognitive functioning. We investigated metabolomic associations with neurocognition in children with CKD. Methods We leveraged data from the Chronic Kidney Disease in Children (CKiD) study and the Neurocognitive Assessment and Magnetic (...) -- Original Article: Chronic Kidney Disease
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18 octobre
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Performance of ChatGPT on Nephrology Test Questions -
Miao, Jing; Thongprayoon, Charat; Garcia Valencia, Oscar A.; Krisanapan, Pajaree; Sheikh, Mohammad S.; Davis, Paul W.; Mekraksakit, Poemlarp; Suarez, Maria Gonzalez; Craici, Iasmina M.; Cheungpasitporn, Wisit
Clin J Am Soc Nephrol
Background ChatGPT is a novel tool that allows people to engage in conversations with an advanced machine learning model. ChatGPT's performance in the US Medical Licensing Examination is comparable with a successful candidate's performance. However, its performance in the nephrology field (...) -- Original Article: Clinical Nephrology
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Background Diagnostic errors are commonly driven by failures in clinical reasoning. Deficits in clinical reasoning are common among graduate medical learners, including nephrology fellows. We created and validated an instrument to assess clinical reasoning in a national cohort of nephrology (...) -- Original Article: Clinical Nephrology
17 octobre
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07:00
BNT162b2 versus mRNA-1273 Third Dose COVID-19 Vaccine in Patients with CKD and Maintenance Dialysis Patients -
Yau, Kevin; Tam, Paul; Chan, Christopher T.; Hu, Queenie; Qi, Freda; Abe, Kento T.; Kurtesi, Alexandra; Jiang, Yidi; Estrada-Codecido, Jose; Brown, Tyler; Liu, Lisa; Siwakoti, Aswani; Leis, Jerome A.; Levin, Adeera; Oliver, Matthew J.; Colwill, Karen; Gingras, Anne-Claude; Hladunewich, Michelle A.
Clin J Am Soc Nephrol
Background There is a lack of randomized controlled trial data regarding differences in immunogenicity of varying coronavirus disease 2019 (COVID-19) mRNA vaccine regimens in CKD populations. Methods We conducted a randomized controlled trial at three kidney centers in Toronto, Ontario, (...) -- Original Article: Maintenance Dialysis
16 octobre
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07:00
Effect of Resveratrol on Endothelial Function in Patients with CKD and Diabetes: A Randomized Controlled Trial -
Gimblet, Colin J.; Kruse, Nicholas T.; Geasland, Katharine; Michelson, Jeni; Sun, Mingyao; Mandukhail, Safur Rehman; Wendt, Linder H.; Eyck, Patrick Ten; Pierce, Gary L.; Jalal, Diana I.
Clin J Am Soc Nephrol
Background Patients with CKD and diabetes are at higher risk of developing cardiovascular disease, in part, because of impaired endothelial function. Cardioprotective compounds such as resveratrol could improve endothelial function and attenuate the cardiovascular burden in patients with CKD (...) -- Original Article: Chronic Kidney Disease
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07:00
Background Current guidelines encourage placement of an arteriovenous (AV) fistula in patients with advanced CKD to avoid initiation of hemodialysis with a central venous catheter. However, the relative merits of predialysis placement of an AV fistula or graft have been poorly studied. Methods (...) -- Original Article: Maintenance Dialysis
9 octobre
6 octobre
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07:00
Targeting APRIL in the Treatment of IgA Nephropathy -
Cheung, Chee Kay; Barratt, Jonathan; Carroll, Kevin; Lafayette, Richard A.; Liew, Adrian; Suzuki, Yusuke; Tesa?, Vladimír; Trimarchi, Hernán; Wong, Muh Geot; Zhang, Hong; Perkovic, Vlado; Rizk, Dana V.
Clin J Am Soc Nephrol
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07:00
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07:00
Background Next-generation implantable and wearable KRTs may revolutionize the lives of patients undergoing dialysis by providing more frequent and/or prolonged therapy along with greater mobility compared with in-center hemodialysis. Medical device innovators would benefit from patient input (...) -- Original Article: Maintenance Dialysis
3 octobre
2 octobre
1er octobre
22 septembre
21 septembre
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07:00
The Significance of Hematuria in Podocytopathies -
Marchel, Dorota; Trachtman, Howard; Larkina, Maria; Helmuth, Margaret; Lai Yee, Jennifer Y.; Fermin, Damian; Bomback, Andrew S.; Canetta, Pietro A.; Gipson, Debbie S.; Mottl, Amy K.; Parekh, Rulan S.; Saha, Manish K.; Sampson, Matthew G.; Lafayette, Richard A.; Mariani, Laura H.; Nephrotic Syndrome Study Network (NEPTUNE) and Cure Glomerulonephropathy (CureGN)
Clin J Am Soc Nephrol
Background Hematuria is frequently present in podocytopathies, but its significance and prognostic value is not well described in these proteinuric kidney diseases. This study describes the prevalence and association between hematuria and kidney-related outcomes in these disorders. Methods (...) -- Original Article: Glomerular and Tubulointerstitial Diseases
20 septembre
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07:00
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by kidney cyst formation and progressive kidney function loss. Dietary interventions such as caloric restriction, intermittent fasting, and ketogenic diet have recently emerged as potential strategies to (...) -- Review
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07:00
Background In the United States, more than 50% of kidneys in the lowest 15% quality range (those with Kidney Donor Profile Index >85) are discarded. Studies suggest that using more of these kidneys could benefit patients waiting for a transplant. This study assesses the trade-offs physicians (...) -- Original Article: Transplantation
18 septembre
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07:00
Nurse Practitioner Care Compared with Primary Care or Nephrologist Care in Early CKD -
James, Matthew T.; Scory, Tayler D.; Novak, Ellen; Manns, Braden J.; Hemmelgarn, Brenda R.; Bello, Aminu K.; Ravani, Pietro; Kahlon, Bhavneet; MacRae, Jennifer M.; Ronksley, Paul E.
Clin J Am Soc Nephrol
Background Early interventions in CKD have been shown to improve health outcomes; however, gaps in access to nephrology care remain common. Nurse practitioners can improve access to care; however, the quality and outcomes of nurse practitioner care for CKD are uncertain. Methods In this (...) -- Original Article: Chronic Kidney Disease
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07:00
Background Hospital-acquired hypernatremia is highly prevalent, overlooked, and associated with unfavorable consequences. There are limited studies examining the outcomes and discharge dispositions of various levels of hospital-acquired hypernatremia in patients with or without CKD. Methods We (...) -- Original Article: Acid Base and Electrolyte Disorders
15 septembre
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07:00
Background Hypocomplementemia and complement co-deposition with monoclonal immunoglobulins in glomeruli are not rare in proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID). Deposition of monoclonal immunoglobulins in glomeruli has been suggested to activate (...) -- Original Article: Glomerular and Tubulointerstitial Diseases
14 septembre
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07:00
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07:00
Background Distal ischemia is a rare complication in patients undergoing placement of an arteriovenous (AV) fistula or AV graft. There are limited studies on its frequency, risk factors, clinical consequences, or feasibility of subsequent access. Methods A prospective vascular access database (...) -- Original Article: Maintenance Dialysis
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07:00
12 septembre
11 septembre
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07:00
Background Secondary hyperparathyroidism is a major complication of patients undergoing hemodialysis (HD). Upacicalcet, a new injectable calcimimetic, acts on calcium-sensing receptors to suppress parathyroid hormone (PTH) secretion. We examined the efficacy and safety of upacicalcet in (...) -- Original Article: Maintenance Dialysis
8 septembre
6 septembre
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07:00
Chronic interstitial nephritis in agricultural communities (CINAC) is an epidemic of kidney disease affecting specific tropical and subtropical regions worldwide and is characterized by progressive CKD in the absence of traditional risk factors, such as hypertension and diabetes. CINAC (...) -- Review
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07:00
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07:00
Advocacy and policy change are powerful levers to improve quality of care and better support patients on home dialysis. While the kidney community increasingly recognizes the value of home dialysis as an option for patients who prioritize independence and flexibility, only a minority of (...) -- Home Dialysis – Fundamentals and Beyond
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07:00
Obinutuzumab in Frequently Relapsing and Steroid-Dependent Nephrotic Syndrome in Children -
Dossier, Claire; Bonneric, Stéphanie; Baudouin, Véronique; Kwon, Thérésa; Prim, Benjamin; Cambier, Alexandra; Couderc, Anne; Moreau, Christelle; Deschenes, Georges; Hogan, Julien
Clin J Am Soc Nephrol
Background B-cell depletion with rituximab induces sustained remission in children with steroid-dependent or frequently relapsing nephrotic syndrome. However, most patients relapse after B-cell recovery, and some patients do not achieve B-cell depletion. Obinutuzumab is a second-generation (...) -- Original Article: Glomerular and Tubulointerstitial Diseases
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07:00
Background Men with CKD tend to experience a faster eGFR decline than women, potentially because of sex hormones. Limited research exists regarding the effect of gender-affirming hormone therapy (GAHT) on kidney function. Furthermore, monitoring kidney function during GAHT is challenging (...) -- Original Article: Clinical Nephrology
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07:00
Background Catheter?related bloodstream infections (CRBSIs) are one of the most prevalent, fatal, and costly complications of hemodialysis with a central venous catheter (CVC). The LOCK IT-100 trial compared the efficacy and safety of a taurolidine/heparin catheter lock solution that combines (...) -- Original Article: Maintenance Dialysis
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07:00
4 septembre
1er septembre
31 août
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07:00
Globally, there is an interest to increase home dialysis utilization. The most recent United States Renal Data System (USRDS) data report that 13.3% of incident dialysis patients in the United States are started on home dialysis, while most patients continue to initiate KRT with in-center (...) -- Home Dialysis – Fundamentals and Beyond
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07:00
Mesangial C3 Deposition, Complement-Associated Variant, and Disease Progression in IgA Nephropathy -
Kang, Yuqi; Xu, Boyang; Shi, Sufang; Zhou, Xujie; Chen, Pei; Liu, Lijun; Li, Yebei; Leng, Yueqi; Lv, Jicheng; Zhu, Li; Zhang, Hong
Clin J Am Soc Nephrol
Background IgA nephropathy is the most common primary GN worldwide, with dominant deposition of IgA and co-deposits of complement component 3 (C3). Phenotypes and progression of IgA nephropathy varies among different ethnic populations, while patients with IgA nephropathy from Asia showed more (...) -- Original Article: Glomerular and Tubulointerstitial Diseases
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07:00
29 août
28 août
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07:00
Writing a home hemodialysis (HD) prescription is a complex, multifactorial process that requires the incorporation of patient values, preferences, and lifestyle. Knowledge of the different options available for home HD modality (conventional, nocturnal, short daily, and alternate nightly) is (...) -- Home Dialysis – Fundamentals and Beyond
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07:00
Pharmacologic inhibition of the sodium-glucose transporter 2 (SGLT2) in the proximal tubule brings about physiologic changes predicted to both increase and decrease kidney K+ excretion. Despite these effects, disorders of plasma K+ concentration are an uncommon occurrence. If anything, these (...) -- Review
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07:00
Interstitial Eosinophilic Aggregates and Kidney Outcome in Patients with CKD -
Hattori, Koki; Sakaguchi, Yusuke; Oka, Tatsufumi; Asahina, Yuta; Kawaoka, Takayuki; Yamamoto, Ryohei; Matsui, Isao; Mizui, Masayuki; Kaimori, Jun-Ya; Isaka, Yoshitaka
Clin J Am Soc Nephrol
Background Interstitial eosinophilic aggregates are observed in various kidney diseases, but their clinical implications remain unknown. We assessed the association between interstitial eosinophilic aggregates and kidney outcomes and further analyzed the association between blood eosinophil (...) -- Original Article: Glomerular and Tubulointerstitial Diseases
24 août
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07:00
A healthy and functional peritoneal membrane is key to achieving sufficient ultrafiltration and restoring fluid balance, a major component of high-quality prescription in patients treated with peritoneal dialysis (PD). Variability in membrane function at the start of PD or changes over time on (...) -- Home Dialysis – Fundamentals and Beyond
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07:00
Rare Variants in Complement Gene in C3 Glomerulopathy and Immunoglobulin-Mediated Membranoproliferative GN -
Meuleman, Marie Sophie; Vieira-Martins, Paula; El Sissy, Carine; Audard, Vincent; Baudouin, Véronique; Bertrand, Dominique; Bridoux, Frank; Louillet, Férielle; Dossier, Claire; Esnault, Vincent; Jourde-Chiche, Noémie; Karras, Alexandre; Morin, Marie-Pascale; Provot, François; Remy, Philippe; Ribes, David; Rousset-Rouviere, Caroline; Servais, Aude; Thervet, Eric; Tricot, Leila; Zaidan, Mohamad; Wynckel, Alain; Zuber, Julien; Le Quintrec, Moglie; Frémeaux-Bacchi, Véronique; Chauvet, Sophie
Clin J Am Soc Nephrol
Background C3 glomerulopathy and idiopathic immunoglobulin-mediated membranoproliferative GN (Ig-MPGN) are rare complement-mediated kidney diseases. Inherited forms of C3 glomerulopathy/Ig-MPGN are rarely described. Methods Three hundred ninety-eight patients with C3 glomerulopathy (n=296) or (...) -- Original Article: Glomerular and Tubulointerstitial Diseases
23 août
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07:00
Peritoneal dialysis (PD) enables people to have a home-based therapy, permitting greater autonomy for individuals along with enhanced treatment satisfaction compared with in-center dialysis care. The burden of treatment on PD, however, remains considerable and underpins the need for (...) -- Home Dialysis – Fundamentals and Beyond
21 août
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07:00
Home dialysis utilization has been growing in the United States over the past decade but still lags behind similar socioeconomic nations. More than half of dialysis facilities in the United States either are not licensed to offer home dialysis or, despite a license, have no patients dialyzing (...) -- Home Dialysis – Fundamentals and Beyond
14 août
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07:00
Peritoneal dialysis (PD) represents an important treatment choice for patients with kidney failure. It allows them to dialyze outside the hospital setting, facilitating enhanced opportunities to participate in life-related activities, flexibility in schedules, time and cost savings from (...) -- Home Dialysis – Fundamentals and Beyond
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07:00
Prostaglandin E2, Osmoregulation, and Disease Progression in Autosomal Dominant Polycystic Kidney Disease -
Geurts, Frank; Xue, Laixi; Kramers, Bart J.; Zietse, Robert; Gansevoort, Ron T.; Fenton, Robert A.; Meijer, Esther; Salih, Mahdi; Hoorn, Ewout J.; on behalf of the DIPAK Consortium
Clin J Am Soc Nephrol
Background Prostaglandin E2 (PGE2) plays a physiological role in osmoregulation, a process that is affected early in autosomal dominant polycystic kidney disease (ADPKD). PGE2 has also been implicated in the pathogenesis of ADPKD in preclinical models, but human data are limited. Here, we (...) -- Original Article: Cystic Kidney Disease
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07:00
Changes in Bone Quality after Treatment with Etelcalcetide -
Khairallah, Pascale; Cherasard, Jenna; Sung, Joshua; Agarwal, Sanchita; Aponte, Maria Alejandra; Bucovsky, Mariana; Fusaro, Maria; Silberzweig, Jeffrey; Frumkin, Gail N.; El Hachem, Karim; Schulman, Linda; McMahon, Donald; Allen, Matthew R.; Metzger, Corinne E.; Surowiec, Rachel K.; Wallace, Joseph; Nickolas, Thomas L.
Clin J Am Soc Nephrol
Introduction Secondary hyperparathyroidism is associated with osteoporosis and fractures. Etelcalcetide is an intravenous calcimimetic for the control of hyperparathyroidism in patients on hemodialysis. Effects of etelcalcetide on the skeleton are unknown. Methods In a single-arm, open-label, (...) -- Original Article: Maintenance Dialysis
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07:00
Comparison of Short-Term Outcomes in Kidney Transplant Recipients from SARS-CoV-2–Infected versus Noninfected Deceased Donors -
Yamauchi, Junji; Azhar, Ambreen; Hall, Isaac E.; Bhalla, Anshul; Potluri, Vishnu S.; Tanriover, Bekir; Gupta, Gaurav; Imlay, Hannah; Truax, Crystal; Balaraman, Vasanthi; Raghavan, Divya; Zimmerman, Michael; Campsen, Jeffrey; Rofaiel, George; Baker, Talia; Molnar, Miklos Z.
Clin J Am Soc Nephrol
Background Acceptable post-transplant outcomes were reported in kidney transplant recipients from donors with coronavirus disease 2019 (COVID-19); however, there are no comparative studies with well-matched controls. Methods This multicenter, prospective observational study, which included (...) -- Original Article: Transplantation
9 août
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07:00
Background Twenty to 60% of newly created hemodialysis arteriovenous fistulas do not mature adequately for use. One barrier to developing interventions to improve fistula outcomes is a lack of standardized criteria for maturation. Methods Using data from the multicenter, prospective (...) -- Original Article: Maintenance Dialysis
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07:00
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07:00
8 août
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07:00
Background Fixed-dose combination treatments reduce cardiovascular disease in primary prevention. We aim to explore whether those benefits differ in the presence of CKD. Methods We conducted an individual participant data meta-analysis in 18,162 participants on the efficacy and safety of (...) -- Original Article: Chronic Kidney Disease
3 août
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07:00
Molecular Signatures of Glomerular Neovascularization in a Patient with Diabetic Kidney Disease -
Ferkowicz, Michael J.; Verma, Ashish; Barwinska, Daria; Melo Ferreira, Ricardo; Henderson, Joel M.; Kirkpatrick, Mary; Silva, Paolo S.; Steenkamp, Devin W.; Phillips, Carrie L.; Waikar, Sushrut S.; Sutton, Timothy A.; for the Kidney Precision Medicine Project
Clin J Am Soc Nephrol
The Kidney Precision Medicine Project (KPMP) aims to create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways, and targets for novel therapies through molecular investigation of human kidney biopsies obtained from participants with AKI or CKD. We present (...) -- Feature
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07:00
Differences in the Circulating Proteome in Individuals with versus without Sickle Cell Trait -
Cai, Yanwei; Franceschini, Nora; Surapaneni, Aditya; Garrett, Melanie E.; Tahir, Usman A.; Hsu, Li; Telen, Marilyn J.; Yu, Bing; Tang, Hua; Li, Yun; Liu, Simin; Gerszten, Robert E.; Coresh, Josef; Manson, JoAnn E.; Wojcik, Genevieve L.; Kooperberg, Charles; Auer, Paul L.; Foster, Matthew W.; Grams, Morgan E.; Ashley-Koch, Allison E.; Raffield, Laura M.; Reiner, Alex P.
Clin J Am Soc Nephrol
Background Sickle cell trait affects approximately 8% of Black individuals in the United States, along with many other individuals with ancestry from malaria-endemic regions worldwide. While traditionally considered a benign condition, recent evidence suggests that sickle cell trait is (...) -- Original Article: Clinical Nephrology
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07:00
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07:00
1er août
31 juillet
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07:00
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07:00
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07:00
There is widespread interest in expanding the uptake of home dialysis in North America. Although kidney transplantation should be the preferred option in eligible patients, home hemodialysis (HD) and peritoneal dialysis (PD) offer cost-effective options for KRT. In this review, the motivation (...) -- Home Dialysis – Fundamentals and Beyond
27 juillet
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07:00
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07:00
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07:00
Increased Access, Persistent Disparities: Trends in Disparities in Peritoneal Dialysis (PD) Use, 2009–2019 -
Knapp, Christopher D.; Li, Shuling; Kou, Chuanyu; Gilbertson, David T.; Weinhandl, Eric D.; Wetmore, James B.; Hart, Allyson; Johansen, Kirsten L.
Clin J Am Soc Nephrol
Peritoneal dialysis (PD) use has increased in the United States since 2009, but how this has affected disparities in PD use is unclear. We used data from the United States Renal Data System to identify a cohort of incident dialysis patients from 2009 to 2019. We used logistic regression models (...) -- Insights from the USRDS
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07:00
Background Potentially inappropriate medications, or medications that generally carry more risk of harm than benefit in older adults, are commonly prescribed to older adults receiving dialysis. Deprescribing, a systematic approach to reducing or stopping a medication, is a potential solution (...) -- Original Article: Maintenance Dialysis
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07:00
Early Risk Stratification for Natural Disease Course in Fabry Patients Using Plasma Globotriaosylsphingosine Levels -
van der Veen, Sanne J.; Sayed, Mohamed el; Hollak, Carla E.M.; Brands, Marion M.; Snelder, C. Khya S.; Boekholdt, S. Matthijs; Vogt, Liffert; Goorden, Susan M.I.; van Kuilenburg, André B.P.; Langeveld, Mirjam
Clin J Am Soc Nephrol
Background Fabry disease is a very heterogeneous X-linked lysosomal storage disease. Disease manifestations in the kidneys, heart, and brain vary greatly, even between patients of the same sex and with the same disease classification (classical or nonclassical). A biomarker with a strong (...) -- Original Article: Chronic Kidney Disease
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07:00
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07:00
26 juillet
25 juillet
24 juillet
20 juillet
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07:00
Background Gender disparities in access to kidney transplantation are apparent, with women being up to 20% less likely to receive kidney transplant compared with men across different settings and socioeconomic backgrounds. We aimed to describe nephrologists' perspectives on gender disparities (...) -- Original Article: Transplantation
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07:00
Anti-PLA2R Antibody Levels and Clinical Risk Factors for Treatment Nonresponse in Membranous Nephropathy -
Barbour, Sean J.; Fervenza, Fernando C.; Induruwage, Dilshani; Brenchley, Paul E.; Rovin, Brad; Hladunewich, Michelle A.; Reich, Heather N.; Lafayette, Richard; Aslam, Nabeel; Appel, Gerald B.; Zand, Ladan; Kiryluk, Krzysztof; Liu, Lili; Cattran, Daniel C.; for the MENTOR Trial Investigators
Clin J Am Soc Nephrol
Background The 2021 Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend following anti-phospholipase A2 receptor (PLA2R) antibody levels as a marker of treatment response in membranous nephropathy; however, the optimal timing to evaluate antibody levels and how to combine (...) -- Original Article: Glomerular and Tubulointerstitial Diseases
17 juillet
7 juillet
5 juillet
1er juillet
29 juin
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07:00
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07:00
Efficacy of Tixagevimab/Cilgavimab Prophylaxis and Vaccination on Omicron Variants (BA.1, BA.2, BA.5, and BQ.1.1) in Kidney Transplant Recipients -
Bertrand, Dominique; Laurent, Charlotte; Lemée, Veronique; Lebourg, Ludivine; Hanoy, Mélanie; Le Roy, Frank; Nezam, Dorian; Pruteanu, Diana; Grange, Steven; de Nattes, Tristan; Lemoine, Mathilde; Candon, Sophie; Guerrot, Dominique
Clin J Am Soc Nephrol
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07:00
Kaliuresis and Intracellular Uptake of Potassium with Potassium Citrate and Potassium Chloride Supplements: A Randomized Controlled Trial -
Wouda, Rosa D.; Gritter, Martin; Karsten, Micky; Michels, Erik H.A.; Nieuweboer, Tamar M.; Danser, A.H. Jan; de Borst, Martin H.; Hoorn, Ewout J.; Rotmans, Joris I.; Vogt, Liffert
Clin J Am Soc Nephrol
Background A potassium replete diet is associated with lower cardiovascular risk but may increase the risk of hyperkalemia, particularly in people using renin-angiotensin-aldosterone system inhibitors. We investigated whether intracellular uptake and potassium excretion after an acute oral (...) -- Original Article: Acid Base and Electrolyte Disorders
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07:00
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07:00
Patient-Specific Pharmacokinetics and Dasatinib Nephrotoxicity -
Adegbite, Benjamin O.; Abramson, Matthew H.; Gutgarts, Victoria; Musteata, Florin M.; Chauhan, Kinsuk; Muwonge, Alecia N.; Meliambro, Kristin A.; Salvatore, Steven P.; El Ghaity-Beckley, Sebastian; Kremyanskaya, Marina; Marcellino, Bridget; Mascarenhas, John O.; Campbell, Kirk N.; Chan, Lili; Coca, Steven G.; Berman, Ellin M.; Jaimes, Edgar A.; Azeloglu, Evren U.
Clin J Am Soc Nephrol
Background Dasatinib has been associated with nephrotoxicity. We sought to examine the incidence of proteinuria on dasatinib and determine potential risk factors that may increase dasatinib-associated glomerular injury. Methods We examined glomerular injury through urine albumin-creatinine (...) -- Original Article: Glomerular and Tubulointerstitial Diseases
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07:00
Long-Term, Real-World Kidney Outcomes with SGLT2i versus DPP4i in Type 2 Diabetes without Cardiovascular or Kidney Disease -
Melzer Cohen, Cheli; Schechter, Meir; Rozenberg, Aliza; Yanuv, Ilan; Sehtman-Shachar, Dvora R.; Fishkin, Alisa; Rosenzweig, Doron; Chodick, Gabriel; Karasik, Avraham; Mosenzon, Ofri
Clin J Am Soc Nephrol
Background Contemporary guidelines recommend the use of sodium-glucose cotransporter 2 inhibitors (SGLT2is) independently of glycemic control in patients with type 2 diabetes and those with kidney disease, with heart failure, or at high risk of cardiovascular disease. Using a large Israeli (...) -- Original Article: Diabetes and the Kidney
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07:00
Ferric Carboxymaltose in Iron-Deficient Patients with Hospitalized Heart Failure and Reduced Kidney Function -
Macdougall, Iain C.; Ponikowski, Piotr; Stack, Austin G.; Wheeler, David C.; Anker, Stefan D.; Butler, Javed; Filippatos, Gerasimos; Göhring, Udo-Michael; Kirwan, Bridget-Anne; Kumpeson, Vasuki; Metra, Marco; Rosano, Giuseppe; Ruschitzka, Frank; van der Meer, Peter; Wächter, Sandra; Jankowska, Ewa A.
Clin J Am Soc Nephrol
Background Reduced kidney function is common among patients with heart failure. In patients with heart failure and/or kidney disease, iron deficiency is an independent predictor of adverse outcomes. In the AFFIRM-AHF trial, patients with acute heart failure with iron deficiency treated with (...) -- Original Article: Chronic Kidney Disease
28 juin
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07:00
Treatment Guidelines for Hyponatremia: Stay the Course -
Sterns, Richard H.; Rondon-Berrios, Helbert; Adrogué, Horacio J.; Berl, Tomas; Burst, Volker; Cohen, David M.; Christ-Crain, Mirjam; Cuesta, Martin; Decaux, Guy; Emmett, Michael; Garrahy, Aoife; Gankam-Kengne, Fabrice; Hix, John K.; Hoorn, Ewout J.; Kamel, Kamel S.; Madias, Nicolaos E.; Peri, Alessandro; Refardt, Julie; Rosner, Mitchell H.; Sherlock, Mark; Silver, Stephen M.; Soupart, Alain; Thompson, Chris J.; Verbalis, Joseph G.; on behalf of PRONATREOUS Investigators
Clin J Am Soc Nephrol
International guidelines designed to minimize the risk of complications that can occur when correcting severe hyponatremia have been widely accepted for a decade. On the basis of the results of a recent large retrospective study of patients hospitalized with hyponatremia, it has been suggested (...) -- Review
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07:00
27 juin
Dernière syndication
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