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- - AJKD
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- - J Hypertens
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115 articles
18 juin
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Evolutionary Differences in Uric Acid Metabolism Inform about the Risks of Pig-to-Human Kidney Transplant - J Am Soc NephrolNo abstract available -- Perspective
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07:00Association between Acute Declines in Estimated Glomerular Filtration Rate during Renin-Angiotensin System Inhibition and Risk of Adverse Outcomes - J Am Soc NephrolBackground: Declines in glomerular filtration rate (GFR) occur commonly when renin-angiotensin system (RAS) inhibitors are started. Our objective was to determine the relation between declines in estimated GFR during trials of RAS inhibition and kidney outcomes. Methods: We included participants (…) -- Original Article: Chronic Kidney Disease
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07:00Estimated Effect of Restarting Renin-Angiotensin System Inhibitors after Discontinuation on Kidney Outcomes and Mortality - J Am Soc NephrolBackground: While renin-angiotensin system inhibitors (RASi) have been the mainstream treatment for patients with CKD, they are often discontinued due to adverse effects such as hyperkalemia and acute kidney injury. It is unknown whether restarting RASi after discontinuation improves clinical (…) -- Original Article: Chronic Kidney Disease
14 juin
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
No abstract available -- Editorial
12 juin
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
Background Information on metabolomic profiles in kidney stone formers is limited. To examine independent associations between plasma metabolomic profiles and the risk of incident, symptomatic kidney stones in adults, we conducted prospective nested case-control studies in two large cohorts. (…) -- Original Article: Acid Base and Electrolyte Disorders
10 juin
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00METTL3-Mediated N6-methyladenosine mRNA Modification and cGAS-STING Pathway Activity in Kidney Fibrosis - J Am Soc NephrolBackground Chemical modifications on RNA profoundly impact RNA function and regulation. m6A, the most abundant RNA modification in eukaryotes, plays a pivotal role in diverse cellular processes and disease mechanisms. However, its importance is understudied in human chronic kidney disease (CKD) (…) -- Original Article: Genetics
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07:00
Background: Low total kidney volume (TKV) is a risk factor for chronic kidney disease (CKD). However, evaluations of nonlinear relationships, incident events, causal inference, and prognostic utility beyond traditional biomarkers are lacking. Methods: TKV, height-adjusted TKV, and body surface (…) -- Original Article: Chronic Kidney Disease
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07:00No Time for Cancel Culture: The Importance of Banff Pathology Criteria and Clinical Outcomes - J Am Soc NephrolNo abstract available -- Editorial
7 juin
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
Background: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by multiple bilateral kidney cysts which gradually enlarge, resulting in a decline in kidney function. Cyst growth is significantly driven by ATP-dependent chloride secretion mediated by the ion channel TMEM16A. (…) -- Original Article: Cystic Kidney Disease
6 juin
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Glomerular Endothelial Cell Receptor ADGRF5 and the Integrity of the Glomerular Filtration Barrier - J Am Soc NephrolBackground: Glomerular endothelial cells are recognized to be important for maintaining the glomerular filtration barrier. ADGRF5, an adhesion G protein-coupled receptor, has been suggested to be involved in endothelial cell function. However, the role of ADGRF5 in the glomerular filtration (…) -- Original Article: Normal Kidney Structure and Function
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07:00
Background Metabolites represent a read-out of cellular processes underlying states of health and disease. Methods We evaluated cross-sectional and longitudinal associations between 1255 serum and 1398 urine known and unknown (denoted with “X” in name) metabolites (Metabolon HD4, 721 detected in (…) -- Original Article: Chronic Kidney Disease
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07:00
No abstract available -- Research Letter
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07:00
No abstract available -- Letter to the Editor
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07:00Authors' Reply: Utility of Urinary CD4+ T-Cell Count in Detecting ANCA-Associated Vasculitis Renal Relapse - J Am Soc NephrolNo abstract available -- Letter to the Editor
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07:00Utility of Urinary CD4+ T-Cell Count in Detecting ANCA-Associated Vasculitis Renal Relapse - J Am Soc NephrolNo abstract available -- Letter to the Editor
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07:00
No abstract available -- Letter to the Editor
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07:00
No abstract available -- Letter to the Editor
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07:00Authors' Reply: Dialysate Sodium and Mortality: 140 mmol/L at Hemodialysis Initiation by Default? - J Am Soc NephrolNo abstract available -- Letter to the Editor
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07:00Dialysate Sodium and Mortality: 140 mmol/L at Hemodialysis Initiation by Default? - J Am Soc NephrolNo abstract available -- Letter to the Editor
3 juin
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
No abstract available -- Editorial
31 mai
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
Background: Secondary hyperparathyroidism of CKD contributes significantly to patient morbidity and mortality. The underlining mechanisms of CKD-induced secondary hyperparathyroidism remain elusive. We previously demonstrated that PT-Dicer-/- mice, with parathyroid specific deletion of the miRNA (…) -- Original Article: Chronic Kidney Disease
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07:00
Background Elderly individuals and chronic kidney disease (CKD) patients are at a higher risk of acute kidney injury (AKI). The transcription factor MondoA is downregulated in the kidneys of aged or AKI patients; however, its roles in AKI development and the AKI-to-CKD transition remain unknown. (…) -- Original Article: Acute Kidney Injury and ICU Nephrology
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07:00
No abstract available -- Editorial
30 mai
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
No abstract available -- Editorial
29 mai
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
No abstract available -- Perspective
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07:00Lipolysis-Stimulated Lipoprotein Receptor in Proximal Tubule, BMP-SMAD Signaling, and Kidney Disease - J Am Soc NephrolBackground Lipolysis-stimulated lipoprotein receptor (LSR) is a single-pass membrane protein which plays essential roles in tricellular tight junction organization in epithelium and endothelium, but its function in kidney physiology and disease development remains unknown. Methods Conditional (…) -- Original Article: Chronic Kidney Disease
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07:00
No abstract available -- Editorial
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07:00
No abstract available -- Letter to the Editor
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07:00Evolution of Biologically Related Living Kidney Donation in the United States from 1988–2022 - J Am Soc NephrolNo abstract available -- Research Letter
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07:00
No abstract available -- Perspective
25 mai
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Effect of Avenciguat on Albuminuria in Patients with CKD: Two Randomized Placebo-Controlled Trials - J Am Soc NephrolBackground: Avenciguat is a novel, potent soluble guanylate cyclase activator in development for CKD. Two trials investigated avenciguat in diabetic (NCT04750577) and non-diabetic (NCT04736628) CKD. Methods: A prespecified pooled analysis of two randomized, double-blind, placebo-controlled (…) -- Original Article: Chronic Kidney Disease
24 mai
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00mTORc2 in Distal-Convoluted-Tubule and Renal K+-Excretion during High Dietary K+ Intake - J Am Soc NephrolBackground: Renal mTORc2 plays a role in regulating renal K+-excretion (renal-EK) and K+-homeostasis. Inhibition of renal mTORc2 caused hyperkalemia due to suppressing epithelial-Na+-channel (ENaC) and ROMK (Kir1.1) in the collecting duct. We now explore whether mTORc2 of DCT regulates (…) -- Original Article: Acid Base and Electrolyte Disorders
22 mai
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
Background: The glomerular basement membrane and the slit diaphragm are essential parts of the filtration barrier. How these layers collaborate remains unclear. The podocyte-like nephrocytes in Drosophila harbor both a slit diaphragm and a basement membrane, serving as a model to address this (…) -- Original Article: Genetics
21 mai
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
Background Diabetes is expected to directly impact renal glycosylation, yet to date, there has not been a comprehensive evaluation of alterations in N-glycan composition in the glomeruli of patients with diabetic kidney disease (DKD). Methods We used untargeted mass spectrometry imaging to (…) -- Original Article: Chronic Kidney Disease
20 mai
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Climate Change, Kidney Health, and Environmentally Sustainable Kidney Care: A Multinational Survey of Health Care Professionals - J Am Soc NephrolKey Points A multinational survey of health care professionals on the kidney health impacts of climate change and the environmental burden of kidney care was conducted.Most participants reported knowledge gaps and high level of concern on these interconnected issues.Only a minority report (…) -- Clinical Research: Clinical Nephrology
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07:00Pharmacokinetic Issue May Influence the Perceived Cardiac Risk Posed by Ondansetron in Patients Undergoing Chronic Hemodialysis - J Am Soc NephrolNo abstract available -- Letter to the Editor
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07:00Authors' Reply: Pharmacokinetic Issue May Influence the Perceived Cardiac Risk Posed by Ondansetron in Patients Undergoing Chronic Hemodialysis - J Am Soc NephrolNo abstract available -- Letter to the Editor
15 mai
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
No abstract available -- Innovator Corner
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07:00
Background: Chronic kidney disease (CKD) is currently defined using glomerular filtration rate (GFR) or albuminuria. This is based on the relative risk of mortality and kidney outcomes compared to a healthy population and does not consider an individual’s absolute risk of CKD progression. (…) -- Original Article: Chronic Kidney Disease
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07:00
No abstract available -- Innovator Corner
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07:00
No abstract available -- Editorial
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07:00
No abstract available -- Editorial
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07:00
No abstract available -- Innovator Corner
9 mai
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
No abstract available -- Designing Clinical Trials
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07:00Defining, Understanding, and Addressing Postdialysis Fatigue: Takeaways from a Scientific Workshop Hosted by the National Institutes of Health - J Am Soc NephrolNo abstract available -- Perspective
7 mai
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Engaging Patients in Decision Making about Treatment of Kidney Failure: The Art and Science of Communication - J Am Soc NephrolNo abstract available -- Editorial
6 mai
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
Mounting evidence indicates that monogenic disorders are the underlying cause in a significant proportion of patients with CKD. In recent years, the diagnostic yield of genetic testing in these patients has increased significantly as a result of revolutionary developments in genetic sequencing (…) -- Mechanisms of Kidney Diseases
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07:00Single-Cell Transcriptional Signatures of Glomerular Disease in Transgenic Mice with APOL1 Variants - J Am Soc NephrolKey Points Apolipoprotein L1 (APOL1)-G1 induced kidney disease in the two APOL1 transgenic mouse models, HIV-associated nephropathy and IFN-? administration.Glomerular single-nuclear RNA-sequencing identified genes differentially expressed among mice with APOL1-G1 and G0 variants at single-cell (…) -- Basic Research: Glomerular and Tubulointerstitial Diseases
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07:00Complement Terminal Pathway Activation and Intrarenal Immune Response in C3 Glomerulopathy - J Am Soc NephrolKey Points We evidenced terminal pathway activation (C5b-9 deposits) in most of the glomeruli on kidney biopsy of C3 glomerulopathy.The amount of C5b-9 deposits correlated with disease prognosis in C3 glomerulopathy.Increased terminal pathway activation was found predominantly in a subgroup (…) -- Basic Research: Glomerular and Tubulointerstitial Diseases
2 mai
J Am Soc Nephrol https://jasn.asnjournals.org/
30 avril
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
Background Acute kidney injury (AKI) is common in hospitalized patients and is associated with high mortality. Inflammation plays a key role in the pathophysiology of AKI. Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of the inflammatory and immune response, but its (…) -- Original Article: Acute Kidney Injury and ICU Nephrology
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07:00Long Non-coding RNA NEAT1, NOD-Like Receptor Family Protein 3 Inflammasome, and Acute Kidney Injury - J Am Soc NephrolKey Points Long non-coding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) was upregulated in human and murine AKI. It returned to baseline after recovery in humans. Its knockdown preserved kidney function in animals.In vitro, LPS upregulated NEAT1 by TLR4/NF-?B signaling and caused (…) -- Basic Research: Acute Kidney Injury and ICU Nephrology
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07:00Circulating Proteins and IgA Nephropathy: A Multiancestry Proteome-Wide Mendelian Randomization Study - J Am Soc NephrolKey Points A multiancestry proteome-wide Mendelian randomization analysis was conducted for IgA nephropathy.The findings from the study would help prioritize new drug targets and drug-repurposing opportunities. Background The therapeutic options for IgA nephropathy are rapidly evolving, but (…) -- Basic Research: Chronic Kidney Disease
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07:00Patient-Reported Outcomes as End Points in Nephrology Trials: Designing the Right Trial for the Right Question - J Am Soc NephrolNo abstract available -- Designing Clinical Trials
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07:00
Background: The therapeutic options for IgA nephropathy are rapidly evolving, but early diagnosis and targeted treatment remain challenging. We aimed to identify circulating plasma proteins associated with IgA nephropathy by proteome-wide mendelian randomization studies across multiple (...) -- Original Article: Chronic Kidney Disease
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07:00American Society of Nephrology Efforts to Address Challenges Highlighted in Recent Joint Global Consensus Statement Issued with European Renal Association and International Society of Nephrology - J Am Soc NephrolNo abstract available -- Perspective
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07:00ASN Efforts to Address Challenges Highlighted in Recent Joint Global Consensus Statement Issued with ERA and ISN - J Am Soc NephrolNo abstract available -- Perspective
26 avril
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
Key Points Automated peritoneal dialysis (APD) had a higher carbon impact than continuous ambulatory peritoneal dialysis (CAPD).This was due to higher emissions from the manufacture and disposal of APD consumables, and their higher weight, meaning greater transport emissions.Polyvinyl chloride (…) -- Clinical Research: Dialysis
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07:00Neighborhood Racial and Ethnic Segregation and the Risk of Dementia in Older Adults Living with Kidney Failure - J Am Soc NephrolKey Points Regardless of race and ethnicity, older adults with kidney failure residing in or receiving care at dialysis facilities located in high-segregation neighborhoods were at a 1.63-fold and 1.53-fold higher risk of dementia diagnosis, respectively.Older adults with kidney failure residing (…) -- Clinical Research: Dialysis
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07:00Klotho: A Large Protein with Various Beneficial Functions, but also with Therapeutic Value? - J Am Soc NephrolNo abstract available -- Innovator Corner
24 avril
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
Key Points Glomerular proteinuria induces large-scale changes in gene expression along the nephron.Increased protein uptake in the proximal tubule results in axial remodeling and injury.Increased protein delivery to the distal tubule causes dedifferentiation of the epithelium. Background Large (…) -- Basic Research: Chronic Kidney Disease
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07:00
Key Points Proteomic profiling identified 35 blood proteins associated with chronic histopathologic lesions in the kidney.Testican-2 was expressed in the glomerulus, released by the kidney into circulation, and inversely associated with glomerulosclerosis severity.NELL1 was expressed in tubular (…) -- Clinical Research: Chronic Kidney Disease
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07:00
Key Points Our study reveals segment-specific mechanisms in cystic kidney disease and suggests Grhl2 as a modifier of collecting duct–derived cyst progression.Our data demonstrate that genetic deletion of Grhl2 accelerates disease progression in a cystic mouse model. Background The transcription (…) -- Basic Research: Cystic Kidney Disease
23 avril
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Acute Kidney Injury Receiving Dialysis and Dialysis Care after Hospital Discharge - J Am Soc NephrolThe number of patients with AKI receiving outpatient hemodialysis (AKI-D) is increasing. At present, on the basis of limited data, approximately one third of patients with AKI-D who receive outpatient dialysis after hospital discharge survive and regain sufficient kidney function to discontinue (…) -- Review
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07:00American Society of Nephrology Kidney Tutored Research and Education for Kidney Scholars (TREKS) Program: A 10-Year Interim Analysis - J Am Soc NephrolIn response to decreasing numbers of individuals entering into nephrology fellowships, the American Society of Nephrology launched Kidney Tutored Research and Education for Kidney Scholars (TREKS) to stimulate interest in nephrology among medical students, graduate students, and postdoctoral (…) -- Special Article
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07:00
No abstract available -- Erratum
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07:00
In response to decreasing numbers of individuals entering into nephrology fellowships, the American Society of Nephrology launched Kidney TREKS (Tutored Research and Education for Kidney Scholars) to stimulate interest in nephrology among medical students, graduate students, and postdoctoral (...) -- Special Article
19 avril
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00The Clinical Relevance of the Infiltrating Immune Cell Composition in Kidney Transplant Rejection - J Am Soc NephrolKey Points The estimated composition of immune cells in kidney transplants correlates poorly with the primary rejection categories defined by Banff criteria.Spatial cell distribution could be coupled with a detailed cellular composition to assess causal triggers for allorecognition.Intragraft (…) -- Basic Research: Transplantation
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07:00Association of Integrated Proteomic and Metabolomic Modules with Risk of Kidney Disease Progression - J Am Soc NephrolKey Points Integrated analysis of proteome and metabolome identifies modules associated with CKD progression and kidney failure.Ephrin transmembrane proteins and podocyte-expressed CRIM1 and NPNT emerged as central components and warrant experimental and clinical investigation. Background (…) -- Clinical Research: Chronic Kidney Disease
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07:00Integrated Proteomic and Metabolomic Modules associated with Risk of Kidney Disease Progression - J Am Soc NephrolBackground: Proteins and metabolites play crucial roles in various biological functions and are frequently interconnected through enzymatic or transport processes. Methods: We present an integrated analysis of 4,091 proteins and 630 metabolites in the Chronic Renal Insufficiency Cohort Study (...) -- Original Article: Chronic Kidney Disease
17 avril
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells - J Am Soc NephrolKey Points Set7 knockout improves diabetic glomerular structure and function and prevents diabetes-induced endothelial–mesenchymal transition (EDMT) by regulating Igfbp5.Set7 knockdown prevents, and (R)-PFI-2 hydrochloride reverses, diabetes-induced EDMT by regulating insulin growth factor (...) -- Basic Research: Diabetes and the Kidney
16 avril
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Correction: Validation of eGFR for Detecting Associations between Serum Protein Biomarkers and Subsequent GFR Decline J Am Soc NephrolNo abstract available -- Erratum
15 avril
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
Key Points We constructed a single-cell long noncoding RNA atlas of various tissues, including normal and aged kidneys.We identified age- and cell type–specific expression changes of long noncoding RNAs in kidney cells. Background Accumulated evidence demonstrates that long noncoding RNAs (…) -- Basic Research: Genetics
11 avril
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00The Effects of Pantoprazole on Kidney Outcomes: Post Hoc: Observational Analysis from the COMPASS Trial - J Am Soc NephrolKey Points In this post hoc analysis of a randomized controlled trial, the proton pump inhibitor pantoprazole led to a faster rate of eGFR decline as compared with placebo.Additional studies are needed to determine the effect of proton pump inhibitors on those at higher risk of adverse kidney (…) -- Clinical Research: Chronic Kidney Disease
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07:00Bridging Racial Disparities in Access to Kidney Transplantation in the United States: Glass Part-Empty or Part-Full? - J Am Soc NephrolNo abstract available -- Perspective
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07:00In Memoriam of William Lloyd Henrich, MD, MACP: What It Means to Be a Humble Servant Leader - J Am Soc NephrolNo abstract available -- Obituary
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07:00
No abstract available -- Obituary
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07:00
Background: Observational studies have found an association between proton pump inhibitor (PPI) use and worsening kidney function. It is unclear whether these associations are causal. We conducted post-hoc analyses to determine the effect of pantoprazole on kidney function using data from the (...) -- Original Article: Chronic Kidney Disease
10 avril
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00The Mechanism of Kidney Disease due to APOL1 Risk Variants: Involvement of Two Distinct Processes - J Am Soc NephrolNo abstract available -- Perspective
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07:00
No abstract available -- Perspective
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07:00
No abstract available -- Editorial
9 avril
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Immunosuppression Withdrawal in Patients with Lupus Nephritis: When, How, and for Whom Will It Be Safe? - J Am Soc NephrolNo abstract available -- Perspective
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07:00The Gut Microbial Metabolite Trimethylamine N-oxide, Incident CKD, and Kidney Function Decline - J Am Soc NephrolKey Points In community-based US adults, higher plasma trimethylamine N-oxide levels associated with higher risk of incident CKD and greater rate of kidney function decline.Findings from our study support future clinical trials to examine whether lowering plasma trimethylamine N-oxide levels (...) -- Clinical Research: Chronic Kidney Disease
8 avril
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
No abstract available -- Innovator Corner
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07:00
No abstract available -- Innovator Corner
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07:00
No abstract available -- Editorial
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07:00
No abstract available -- Editorial
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07:00Consent for High–Kidney Donor Profile Index Kidneys: The Responsibility of Transplant Centers to Get it Right - J Am Soc NephrolNo abstract available -- Editorial
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07:00
No abstract available -- Editorial
1er avril
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
No abstract available -- Perspective
26 mars
J Am Soc Nephrol https://jasn.asnjournals.org/
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06:00Genome-Wide CRISPR Screen Identifies Phospholipid Scramblase 3 as the Biological Target of Mitoprotective Drug SS-31 - J Am Soc NephrolKey Points Szeto–Schiller-31–mediated mitoprotection is phospholipid scramblase 3–dependent.Phospholipid scramblase 3 is required for recovery after AKI. Background The synthetic tetrapeptide Szeto–Schiller (SS)-31 shows promise in alleviating mitochondrial dysfunction associated with common (...) -- Basic Research: Acute Kidney Injury and ICU Nephrology
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06:00Rab35 Is Required for Embryonic Development and Kidney and Ureter Homeostasis through Regulation of Epithelial Cell Junctions - J Am Soc NephrolKey Points Loss of Rab35 leads to nonobstructive hydronephrosis because of loss of ureter epithelium.Rab35 regulates kidney and ureter epithelial cell adhesion and polarity.Rab35 is required for embryonic development. Background Rab35 is a member of a GTPase family of endocytic trafficking (...) -- Basic Research: Development of the Kidney
22 mars
J Am Soc Nephrol https://jasn.asnjournals.org/
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06:00
Key Points Clinicians’ uncertainty about the degree to which older patients prefer to engage in decision making remains a key barrier to shared decision making.Most older adults with advanced CKD preferred a collaborative or active role in decision making. Background Older adults with kidney (...) -- Clinical Research: Dialysis
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06:00
No abstract available -- Innovator Corner
21 mars
J Am Soc Nephrol https://jasn.asnjournals.org/
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06:00
Key Points Patients with AA amyloidosis and age ?65 years, eGFR 1000 ng/L and/or type-B natriuretic peptide >130 ng/L at diagnosis have poorer survival.Proteinuria >3.0 g/24 hours and eGFR 130 ng/L and/or N-terminal type-B natriuretic peptide >1000 ng/L) were associated with overall survival (...) -- Clinical Research: Chronic Kidney Disease
19 mars
J Am Soc Nephrol https://jasn.asnjournals.org/
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06:00WWP2 Regulates Renal Fibrosis and the Metabolic Reprogramming of Profibrotic Myofibroblasts - J Am Soc NephrolKey Points WWP2 expression is elevated in the tubulointerstitium of fibrotic kidneys and contributes to CKD pathogenesis and progression.WWP2 uncouples the profibrotic activation and cell proliferation in renal myofibroblasts.WWP2 controls mitochondrial respiration in renal myofibroblasts (...) -- Basic Research: Chronic Kidney Disease
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06:00WWP2 Regulates Kidney Fibrosis and the Metabolic Reprogramming of Profibrotic Myofibroblasts - J Am Soc NephrolBackground Renal fibrosis is a common pathological endpoint in CKD that is challenging to reverse, and myofibroblasts are responsible for the accumulation of a fibrillar collagen-rich extracellular matrix (ECM). Recent studies have unveiled myofibroblasts diversity in terms of proliferative (...) -- Original Article: Chronic Kidney Disease
12 mars
J Am Soc Nephrol https://jasn.asnjournals.org/
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06:00Posoleucel in Kidney Transplant Recipients with BK Viremia: Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial - J Am Soc NephrolKey Points Posoleucel was generally safe, well tolerated, and associated with a greater reduction of BK viremia compared with placebo.BK viremia reduction occurred coincident with an increase in the circulating frequency of BK virus–specific T cells in posoleucel recipients.The presence and (...) -- Clinical Research: Transplantation
6 mars
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Reduced Nephron Endowment in Six2-TGCtg Mice Is Due to Six3 Misexpression by Aberrant Enhancer–Promoter Interactions in the Transgene - J Am Soc NephrolKey Points Aberrant enhancer–promoter interactions detected by Hi-C drive ectopic expression of Six3 in the Six2TGCtg line.Disruption of Six3 in the Six2TGCtg line restores nephron number, implicating SIX3 interference with SIX2 function in nephron progenitor cell renewal. Background Lifelong (...) -- Basic Research: Development of the Kidney
29 février
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
No abstract available -- Designing Clinical Trials
27 février
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Ondansetron and the Risk of Sudden Cardiac Death among Individuals Receiving Maintenance Hemodialysis - J Am Soc NephrolKey Points In hemodialysis, ondansetron initiation versus initiation of lesser QT-prolonging antiemetics associated with higher 10-day sudden cardiac death risk.Analyses considering additional cardiac outcomes had consistent findings. Background Individuals receiving hemodialysis have a high (...) -- Clinical Research: Dialysis
22 février
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
Key Points Patients with CKD face meaningful risk of heart failure hospitalization.Daprodustat compared with darbepoetin was associated with a nonsignificantly greater number of heart failure hospitalizations in non-dialysis patients. Background Patients with CKD are at higher risk of heart (...) -- Clinical Research: Chronic Kidney Disease
20 février
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Combination Treatment with Verinurad and Allopurinol in CKD: A Randomized Placebo and Active Controlled Trial - J Am Soc NephrolKey Points The SAPPHIRE trial was designed to assess albuminuria-lowering effects of the urate transporter 1 inhibitor verinurad combined with allopurinol in patients with CKD.Verinurad 3, 7.5, and 12 mg in combination with allopurinol 300 mg did not reduce albuminuria during 34 weeks (...) -- Clinical Research: Chronic Kidney Disease
14 février
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Sensing Dying Cells in Health and Disease: The Importance of Kidney Injury Molecule-1 - J Am Soc NephrolKidney injury molecule-1 (KIM-1), also known as T-cell Ig and mucin domain-1 (TIM-1), is a widely recognized biomarker for AKI, but its biological function is less appreciated. KIM-1/TIM-1 belongs to the T-cell Ig and mucin domain family of conserved transmembrane proteins, which bear the (...) -- Mechanisms of Kidney Diseases
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07:00
Key Points We created a comprehensive reference atlas of normal human kidney endothelial cells.We confirmed that endothelial cell types in the human kidney were also highly conserved in the mouse kidney. Background Kidney endothelial cells are exposed to different microenvironmental conditions (...) -- Basic Research: Normal Kidney Structure and Function
13 février
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Quantifying the Effect of Consent for High–Kidney Donor Profile Index Deceased Donor Transplants in the United States - J Am Soc NephrolKey Points Nationally, 41% of kidney transplant candidates consented to receive high–Kidney Donor Profile Index (KDPI) donor offers in the United States.There was wide variation in consent proportion for high-KDPI donors on the basis of individual characteristics and transplant centers.Consent (...) -- Clinical Research: Transplantation
9 février
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Foxp1 is Required for Renal Intercalated Cell Differentiation and Acid–Base Regulation - J Am Soc NephrolKey Points Foxp1 is a key transcriptional factor for the differentiation of intercalated cells in collecting ducts.Dmrt2 and Hmx2 act downstream of Foxp1 to control the differentiation of type A and type B intercalated cells, respectively.Foxp1 and Dmrt2 are essential for body acid–base (...) -- Basic Research: Acid Base and Electrolyte Disorders
8 février
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Correction: The Primary-Secondary Care Partnership to Improve Outcomes in Chronic Kidney Disease (PSP-CKD) Study: A Cluster Randomized Trial in Primary Care J Am Soc NephrolNo abstract available -- Erratum
7 février
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Small Molecule Allosteric Inhibitor of HIPK2 as a Novel Therapy against Kidney Fibrosis - J Am Soc NephrolNo abstract available -- Innovator Corner: Chronic Kidney Disease
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07:00Single-Cell RNA Sequencing Identifies Response of Renal Lymphatic Endothelial Cells to Acute Kidney Injury - J Am Soc NephrolSignificance Statement The renal lymphatic vasculature and the lymphatic endothelial cells that make up this network play important immunomodulatory roles during inflammation. How lymphatics respond to AKI may affect AKI outcomes. The authors used single-cell RNA sequencing to characterize (...) -- Basic Research: Acute Kidney Injury and ICU Nephrology
6 février
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Cardiovascular-Kidney-Metabolic Health Syndrome: What Does the American Heart Association Framework Mean for Nephrology? - J Am Soc NephrolNo abstract available -- Perspective
29 janvier
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Allocation and Utilization Patterns of Deceased Donor Kidneys for Preemptive Transplantation in the United States - J Am Soc NephrolNo abstract available -- Research Letter: Transplantation
26 janvier
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00
Hemodialysis is a life-saving treatment for patients with kidney failure. However, patients requiring hemodialysis have a 10–20 times higher risk of cardiovascular morbidity and mortality than that of the general population. Patients encounter complications such as episodic intradialytic (...) -- Review
13 décembre
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Effect of Ziltivekimab on Determinants of Hemoglobin in Patients with CKD Stage 3–5: An Analysis of a Randomized Trial (RESCUE) - J Am Soc NephrolBackground In the phase 2 RESCUE clinical trial, ziltivekimab, a fully human monoclonal antibody against the IL-6 ligand, significantly reduced the biomarkers of inflammation compared with placebo, in patients with CKD and systemic inflammation (high-sensitivity C-reactive protein ?2 mg/L). The (…) -- Clinical Research: Chronic Kidney Disease