5 juillet

AJKD https://www.ajkd.org/

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  Genetic Characterization of Kidney Failure of Unknown Etiology in Spain: Findings From the GENSEN Study - Miquel Blasco, Borja Quiroga, José M. García-Aznar, Cristina Castro-Alonso, Saulo J. Fernández-Granados, Enrique Luna, Gema Fernández Fresnedo, Marta Ossorio, María Jesús Izquierdo, Didier Sanchez-Ospina, Laura Castañeda-Infante, Ricardo Mouzo, Mercedes Cao, María L. Besada-Cerecedo, Ricardo Pan-Lizcano, Roser Torra, Alberto Ortiz, Patricia de Sequera, GENSEN study investigators AJKD
  Chronic kidney disease (CKD) of unknown etiology (CKDUE) is one of the main global causes of kidney failure. While genetic studies may identify an etiology in these patients, few studies have implemented genetic testing of CKDUE in population-based series of patients which was the focus of the (…) (American Journal of Kidney Diseases (2024))

4 juillet

AJKD https://www.ajkd.org/

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  Humanizing Nephrology: The Power of Social History - Rajiv Agarwal AJKD
  “The good physician treats the disease; the great physician treats the patient who has the disease.”– Sir William Osler (American Journal of Kidney Diseases (2024))
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  Mitigating the Disparate Impacts of Longevity Matching of Kidney Transplants - Sommer E. Gentry, Darren E. Stewart, Allan B. Massie, Dorry L. Segev AJKD
  In this issue of AJKD, Asfour et al1 describe racially disparate impacts of the longevity-matching component of the Kidney Allocation System (KAS) that gives priority for high-longevity kidneys (kidney donor profile index [KDPI] ?20%) to transplant candidates in the top 20% of estimated (…) (American Journal of Kidney Diseases (2024))

3 juillet

AJKD https://www.ajkd.org/

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  Waiting - Justin C. Cordova AJKD
  Act I. (American Journal of Kidney Diseases (2024))

1er juillet

AJKD https://www.ajkd.org/

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  A Patient With Spontaneous Perinephric Hematoma: A Quiz - Prathap Kumar Simhadri, Deepak Chandramohan, Prabhat Singh, Rachana Marathi, Kyle Burton, Pradeep Vaitla AJKD
  A 61-year-old white female patient with a history of hypertension and asthma with culture-negative L5-S1 lumbar diskitis was on intravenous cefepime, vancomycin, and minocycline for nearly 2 weeks when she presented with severe bilateral flank pain, hypotension, tachycardia, and severe anemia. (…) (American Journal of Kidney Diseases 84, 1 (2024))
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  Editorial Board AJKD
  (American Journal of Kidney Diseases 84, 1 (2024))
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  Masthead AJKD
  (American Journal of Kidney Diseases 84, 1 (2024))
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  Table of Contents AJKD
  (American Journal of Kidney Diseases 84, 1 (2024))

24 juin

AJKD https://www.ajkd.org/

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  Sex and the Risk of Atheromatous and Non-Atheromatous Cardiovascular Disease in CKD: Findings From the CKD-REIN Cohort Study - Anne-Laure Faucon, Oriane Lambert, Ziad A. Massy, Tilman B. Drüeke, Christian Combe, Denis Fouque, Luc Frimat, Christian Jacquelinet, Maurice Laville, Sophie Liabeuf, Roberto Pecoits-Filho, Marie Hauguel-Moreau, Nicolas Mansencal, Natalia Alencar de Pinho, Bénédicte Stengel, the CKD-REIN study collaborators AJKD
  Sex differences in cardiovascular disease (CVD) are well-established, but whether chronic kidney disease (CKD) modifies these risk differences, and whether they differ between atheromatous (ACVD) and non-atheromatous (N-ACVD) CVD is unknown. Assessing this interaction was the principal goal of (…) (American Journal of Kidney Diseases (2024))
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  Social Isolation, Loneliness, and Risk of Microvascular Complications Among Individuals With Type 2 Diabetes Mellitus - Yannis Yan Liang, Yu He, Jinyu Wang, Yaping Liu, Sizhi Ai, Hongliang Feng, Changguo Zhu, Haiteng Li, Yujing Zhou, Jihui Zhang, Jun Zhang, Lu Qi AJKD
  Social disconnection has been associated with poor cardiometabolic health. This study sought to investigate the associations of social isolation and loneliness with diabetic microvascular complications (DMC) among individuals with type 2 diabetes mellitus (T2DM) and compare these associations to (…) (American Journal of Kidney Diseases (2024))

21 juin

AJKD https://www.ajkd.org/

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  Smoking Timing, Healthy Diet, and Risk of Incident CKD Among Smokers: Findings From UK Biobank - Rui Tang, Ying Hu, Jian Zhou, Xuan Wang, Xiang Li, Yoriko Heianza, Lu Qi AJKD
  While smoking is a recognized risk factor for chronic kidney disease (CKD), the relationship between the time smoking is initiated after awakening each day and CKD remains largely unstudied. This study examined the association between this timing and the risk of CKD, and the potential (…) (American Journal of Kidney Diseases (2024))

20 juin

AJKD https://www.ajkd.org/

• 00:00
  A Close Look at Metabolic Dysfunction in Autosomal Dominant Polycystic Kidney Disease: From Bench to Imaging - Sol Carriazo, York Pei AJKD
  Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic kidney disease, affecting up to 12 million people worldwide.1 Mutations in 2 major genes, PKD1 and PKD2, account for 70%-85% and 15%-30% of genetically resolved cases, respectively.2 Currently, algorithms employing (…) (American Journal of Kidney Diseases (2024))
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  The Ties That Bind - Antonio Yaghy AJKD
  Thrice weekly pilgrimage, (American Journal of Kidney Diseases (2024))
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  Clinicopathologic Characteristics of Crystalglobulin-Induced Nephropathy: A Case Series - Samih H. Nasr, Satoru Kudose, Anthony M. Valeri, Ali Kashkouli, Samar M. Said, Dominick Santoriello, Glen S. Markowitz, Lihong Bu, Lynn D. Cornell, Adel Samad, Jahangir Ahmed, Sanjeev Sethi, Nelson Leung, Vivette D. D’Agati AJKD
  Crystalglobulinemia is a rare syndrome characterized by intravascular crystallization of monoclonal immunoglobulins (MIgs). Data on kidney involvement are limited to case reports. This series characterizes the clinicopathologic spectrum of crystalglobulin-induced nephropathy (CIN). (American Journal of Kidney Diseases (2024))
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  Transfers From In-Center Hemodialysis to Peritoneal Dialysis: Better Late Than Never? - Ankur D. Shah, Jeffrey Perl AJKD
  Peritoneal dialysis (PD) remains an underutilized dialysis modality despite its many advantages compared to in-center hemodialysis (ICHD), including greater convenience and quality of life, relative preservation of residual kidney function (RKF), and improved early patient survival.1 The (…) (American Journal of Kidney Diseases (2024))
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  Clinical Characteristics and Prognosis of Genetic Focal Segment Glomerulosclerosis - Xu Hao, Shuwen Yu, Qinjie Weng, Zhengying Fang, Qimin Zheng, Yafei Zhao, Jian Liu, Jun Ma, Chunli Zhang, Yunzi Liu, Junru Li, Mingxin Yang, Hong Ren, Jingyuan Xie AJKD
  Focal segmental glomerulosclerosis (FSGS) is a pathological lesion characterized by focal segmental sclerosis with foot-process effacement. The etiology of FSGS is complex, with clinical manifestations ranging from varying degrees of proteinuria to progressive kidney failure [1, 2]. According to (…) (American Journal of Kidney Diseases (2024))

19 juin

AJKD https://www.ajkd.org/

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  Chronic Tonsillitis and IgA Nephropathy: Findings From a Nationwide Japanese Cohort Study - Takashin Nakayama, Hidehiro Kaneko, Yuta Suzuki, Akira Okada, Hiroyuki Morita, Katsuhito Fujiu, Norifumi Takeda, Akira Fukui, Takashi Yokoo, Norihiko Takeda, Hideo Yasunaga, Masaomi Nangaku, Kaori Hayashi AJKD
  Little is known regarding the association between chronic tonsillitis and the onset of IgA nephropathy (IgAN). In the present study, we examined the potential relationship between chronic tonsillitis and a subsequent risk of developing IgAN. (American Journal of Kidney Diseases (2024))
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  Efficacy and Safety of Allopurinol and Febuxostat in Patients With Gout and CKD: Subgroup Analysis of the STOP Gout Trial - Lindsay N. Helget, Anne Davis-Karim, James R. O’Dell, Ted R. Mikuls, Jeff A. Newcomb, Maria Androsenko, Mary T. Brophy, Bryant R. England, Ryan Ferguson, Michael H. Pillinger, Tuhina Neogi, Hongsheng Wu, Paul M. Palevsky AJKD
  We conducted a prespecified examination of the efficacy and safety of allopurinol and febuxostat administered using a treat-to-target strategy in trial participants with chronic kidney disease (CKD). (American Journal of Kidney Diseases (2024))
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  Frailty in Kidney Disease: A Comprehensive Review to Advance Its Clinical and Research Applications - Devika Nair, Christine K. Liu, Rasha Raslan, Mara McAdams-DeMarco, Rasheeda K. Hall AJKD
  Frailty is a multi-system syndrome of decreased physiologic reserve that has been shown to strongly and independently predict morbidity and mortality. Frailty is prevalent in patients living with kidney disease and occurs earlier in individuals with kidney disease as compared to the general (…) (American Journal of Kidney Diseases (2024))

18 juin

AJKD https://www.ajkd.org/

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  The Case for Incremental Thinking About Kidney Stone Disease - Alan C. Pao AJKD
  From a patient’s perspective, you either have a kidney stone or you don’t. Detecting a stone represents an all-or-nothing event, foreshadowing what may come to pass (or not pass). In comparison, evaluating risk of a recurrent stone is a continuous, often iterative, process. Evaluating stone risk (…) (American Journal of Kidney Diseases (2024))
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  In Reply to “Considerations on Potential Modifiers of Glycated Albumin Levels in Patients With CKD” - Mengyao Tang, Sahir Kalim AJKD
  We thank Dr. Chia-Ter Chao for highlighting the role of non-glycemic factors in influencing glycated albumin (GA) levels in patients with chronic kidney disease (CKD).1 (American Journal of Kidney Diseases (2024))
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  Considerations on Potential Modifiers of Glycated Albumin Levels in Patients With CKD - Chia-Ter Chao AJKD
  I was intrigued by Tang et al.’s study on glycated albumin (GA) as a predictor for outcomes in patients with chronic kidney disease (CKD) within the Chronic Renal Insufficiency Cohort.1 Their findings linking higher GA levels to increased kidney and cardiovascular risks are commendable. However, (…) (American Journal of Kidney Diseases (2024))

12 juin

AJKD https://www.ajkd.org/

• 00:00
  Extreme Humid-Heat Exposure and Mortality Among Patients Receiving Dialysis - Matthew F. Blum, Yijing Feng, Cascade P. Tuholske, Byoungjun Kim, Mara A. McAdams DeMarco, Brad C. Astor, Morgan E. Grams AJKD
  Exposure to extreme heat events has been linked to increased morbidity and mortality in the general population. Patients receiving maintenance dialysis may be vulnerable to greater risks from these events, but this is not well understood. We sought to characterize the association of extreme heat (…) (American Journal of Kidney Diseases (2024))
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  Frailty and Duration of Maintenance Dialysis: A Japanese Nationwide Cross-Sectional Study - Suguru Yamamoto, Kakuya Niihata, Tatsunori Toida, Masanori Abe, Norio Hanafusa, Noriaki Kurira AJKD
  End-stage kidney disease increases the risk of frailty. Understanding how long-term dialysis affects physical function may help patients and caregivers plan their lives better. Our research explores the relationship between duration of maintenance dialysis and frailty. We found that longer (…) (American Journal of Kidney Diseases (2024))

10 juin

AJKD https://www.ajkd.org/

• 00:00
  Severe Presentation of Mpox With Skin, Lung and Pleural Involvement in a Non-HIV Infected Kidney Transplant Recipient - Julio Francisco Colina-García, José María Caso, Celia González-García, María Dolores Folgueira, Ana María Hernández, Pilar Auñón, Amado Andrés, Teresa Cavero, Francisco López-Medrano, Enrique Morales AJKD
  Monkeypox (mpox) is an orthopoxviral zoonotic disease with a similar, but less severe, clinical presentation as smallpox. However, immunocompromised patients such as solid organ transplant recipients are at higher risk of developing severe forms of the disease. Herein, we describe the case of a (…) (American Journal of Kidney Diseases (2024))