1er juillet

Kidney Int http://www.kidney-international.org/

• 00:00
  MRI findings of renal cortical hemosiderosis after cardiac valve surgery - Haijuan Lv, Hongwei Zhao Kidney Int
  A 74-year-old female patient, at 9 years post mitral and tricuspid valve repairs with C-shaped annuloplasty rings, presented with proteinuria (2+) and anemia (Hb 97 g/l), and elevated lactate dehydrogenase levels at 845 U/L (reference range: 120–250 U/L), indicative of intravascular hemolysis. (…) (Kidney International 106, 1 (2024))
• 00:00
  Solitary kidney in a patient with Pallister-Hall syndrome - Ines Vanderheyden, Saskia Bulk, François Jouret Kidney Int
  A 58-year-old female patient was referred for solitary kidney management. She was born following a full-term pregnancy, with a weight of 2.2 kg. Her medical history included the following: (i) “Y-shaped metacarpals” and postaxial polydactyly (15 fingers in toto) bilaterally operated (Figure 1); (…) (Kidney International 106, 1 (2024))
• 00:00
  Taking the amphoterism out of amphotericin: a wonder drug in the making - Andrew Beenken Kidney Int
  Invasive fungal infections number up to 1,000,000 cases per year,1 and an increasing number exhibit multidrug resistance. Amphotericin B has been an important tool in fighting these infections ever since the 1950s when it was first isolated from the soil of the Orinoco basin in Venezuela.2 (…) (Kidney International 106, 1 (2024))
• 00:00
  Inflammasome activation: unraveling the link between chronic kidney disease and atrial fibrillation - Melis Sahinoz, T. Alp Ikizler Kidney Int
  Atrial fibrillation (AF) is the most common cardiac arrhythmia, currently affecting ?60 million people worldwide, and it is associated with significant morbidity and mortality.1 Chronic kidney disease (CKD) is an independent risk factor for incident and prevalent AF, with a stepwise increase in (…) (Kidney International 106, 1 (2024))
• 00:00
  Corrigendum to “Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax.” Kidney International 2023;103:115–133 - Jingyao Li, Xi’ang Sun, Ninghao Yang, Jiayun Ni, Hongyan Xie, Hengjiang Guo, Xin Wang, Li Zhou, Jun Liu, Sijia Chen, Xiaoxia Wang, Yingying Zhang, Chen Yu, Wei Zhang, Limin Lu Kidney Int
  DOI of original article: https://doi.org/10.1016/j.kint.2022.08.022 (Kidney International 106, 1 (2024))
• 00:00
  Corrigendum to “Kidney involvement in Rosai-Dorfman disease.” Kidney International 2023;103:231–232 - Martina Mazzariol, Francesco Peyronel, Filippo Fagni, Andrea Minervini, Raffaella Santi, Simone Agostini, Augusto Vaglio Kidney Int
  DOI of original article: 10.1016/j.kint.2022.09.005 (Kidney International 106, 1 (2024))
• 00:00
  Foscarnet-induced nephropathy in a kidney transplant recipient - Ian P. Rios, Christian H.L. Nguyen, Suman S. Misra, Margaret S. Ryan, Sumi S. Nair, Hasan A. Khamash Kidney Int
  A 53-year-old man with type 2 diabetes–related kidney failure underwent cytomegalovirus (CMV)–mismatched (CMV positive to negative), deceased donor kidney transplant in July 2021. He was on a prophylactic dose of valganciclovir until September 2021 when he developed neutropenia, and (…) (Kidney International 106, 1 (2024))
• 00:00
  The Case | Rapid onset of severe hyponatremia after a dental procedure - Laura Scholz, Max Schuller, Michael Kolland, Philipp Eller, Alexander H. Kirsch Kidney Int
  A 38-year-old woman presented at a peripheral hospital for progressive abdominal pain, nausea, and vomiting. Except for a 7-day course of antibiotic treatment following a dental procedure performed a few days before symptom onset, she had not been on any medication. Her medical history was not (…) (Kidney International 106, 1 (2024))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 106, 1 (2024))
• 00:00
  Erratum to “An update on clinical presentation and responses to therapy of patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH).” Kidney International 2023;105:1058–1076 - Zewu Zhu, Bryan Bo-Ran Ho, Alyssa Chen, James Amrhein, Andreea Apetrei, Thomas Oliver Carpenter, Marise Lazaretti-Castro, Juan Manuel Colazo, Kathryn McCrystal Dahir, Michaela Geßner, Evgenia Gurevich, Cathrine Alsaker Heier, Jill Hickman Simmons, Tracy Earl Hunley, Bernd Hoppe, Christina Jacobsen, Anne Kouri, Nina Ma, Sachin Majumdar, Arnaud Molin, Natalie Nokoff, Susan M. Ott, Helena Gil Peña, Fernando Santos, Peter Tebben, Lisa Swartz Topor, Yanhong Deng, Clemens Bergwitz Kidney Int
  The publisher regrets that the definition of het-post (post-treatment levels of het carriers) was not included in the legends of Figure 3 and Supplementary Figure S3, and that descriptions of upper limit (%UL) and/or z-score were not included in the legends of Supplementary Figures S2–S4, S6, (…) (Kidney International 106, 1 (2024))
• 00:00
  Preventing MMP23-mediated cleavage of podocyte RARRES1: a novel strategy to halt chronic kidney disease progression? - Paulina X. Medina Rangel, Shuta Ishibe Kidney Int
  Glomerular issues and affected podocytes are at the origin of 80% of chronic kidney disease cases. Thus, acquiring a deeper understanding in this domain is necessary to halt progressive kidney damage. In this study, the authors investigated the harmful impact of podocyte-cleaved soluble retinoic (…) (Kidney International 106, 1 (2024))
• 00:00
  Genomics in the kidney transplant clinic: the future standard of care? - Emilie Cornec-Le Gall, Andrew J. Mallett Kidney Int
  New evidence indicates potential benefit of genomics to illuminate nonkidney monogenic morbidity and mortality risk among kidney transplant recipients. This might be of direct relevance to an equivalent proportion of patients to those who harbor a monogenic kidney disease. Further evidence and (…) (Kidney International 106, 1 (2024))
• 00:00
  journal club Kidney Int
  Verma et al. (Ann Intern Med. 2024;177:467–475.) (Kidney International 106, 1 (2024))
• 00:00
  in this issue Kidney Int
  Asowata and colleagues studied deceased donor transplant kidneys with impaired kidney function as a model of acute and chronic kidney injury using an integrated multi-omic approach. RNA sequencing demonstrated that T cell and macrophage tissue infiltration associated with changes in both donors’ (…) (Kidney International 106, 1 (2024))
• 00:00
  Factor XI inhibition in hemodialysis patients: the safer anticoagulation? - Eleni Stamellou, Heidi Noels, Jürgen Floege Kidney Int
  Chronic hemodialysis patients exhibit an excessive cardiovascular risk and a marked increase in both thromboembolism and bleeding episodes. Factor XI inhibition may provide anticoagulation, with a low risk of bleeding, and several factor XI inhibitors, including fesomersen, an antisense (…) (Kidney International 106, 1 (2024))
• 00:00
  Table of Contents Kidney Int
  (Kidney International 106, 1 (2024))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 106, 1 (2024))

27 juin

Kidney Int http://www.kidney-international.org/

• 00:00
  Targeted RNAseq from patients’ urinary cells to validate pathogenic non coding variants in Autosomal Dominant Polycystic Kidney Disease genes: a proof of concept. - Guillaume Dorval, Gérald Le Gac, Vincent Morinière, Chandran Ka, Claire Goursaud, Bertrand Knebelmann, Pierre Marijon, Sophie Nambot, Nicolas Cagnard, Patrick Nitschké, Laurence Michel-Calemard, Marie-Pierre Audrézet, Laurence Heidet Kidney Int
  Genetic testing remains unconclusive in 7-10% of families affected with autosomal dominant polycystic kidney disease (ADPKD), despite thorough sequencing of all known exons of PKD1 and PKD2, the two major ADPKD genes, and of other genes involved such as IFT140, GANAB, DNAJB11, ALG5, ALG8, ALG9, (…) (Kidney International (2024))

18 juin

Kidney Int http://www.kidney-international.org/

• 00:00
  A meta-analysis of randomized controlled clinical trials implications of acute treatment effects on glomerular filtration rate for long-term kidney protection. - Hiddo J.L. Heerspink, Devin Eddington, Juhi Chaudhari, Raymond Estacio, Enyu Imai, Marian Goicoechea, Thierry Hannedouche, Richard Haynes, Tazeen H. Jafar, David W. Johnson, Rob C.M. van Kruijsdijk, Julia B. Lewis, Philip K.T. Li, Brendon L. Neuen, Ronald D. Perrone, Piero Ruggenenti, Christoph Wanner, Mark Woodward, Di Xie, Tom Greene, Lesley A. Inker Kidney Int
  Pharmacologic interventions to slow chronic kidney disease progression, such as ACE-inhibitors, angiotensin receptor blockers, or sodium glucose co-transporter 2 inhibitors, often produce acute treatment effects on glomerular filtration rate (GFR) that differ from their long-term chronic (…) (Kidney International (2024))
• 00:00
  Effects of microplastics on the kidneys: A narrative review - Rodrigo Bueno de Oliveira, Lauter E. Pelepenko, Daniela A. Masaro, Glauco M.M. M. Lustosa, Mariana Cassani, Noemí A.V. Roza, Marina A. Marciano, Luciene M. dos Reis, Saïd Kamel, Loïc Louvet, Talita Mazon. Kidney Int
  Micro- and nanoplastics (MPs) are small synthetic organic polymer particles ( (Kidney International (2024))
• 00:00
  A genetically inducible endothelial niche enables vascularization of human kidney organoids with multilineage maturation and emergence of renin expressing cells. - Joseph C. Maggiore, Ryan LeGraw, Aneta Przepiorski, Jeremy Velazquez, Christopher Chaney, Thitinee Vanichapol, Evan Streeter, Zainab Almuallim, Akira Oda, Takuto Chiba, Anne Silva-Barbosa, Jonathan Franks, Joshua Hislop, Alex Hill, Haojia Wu, Katherine Pfister, Sara E. Howden, Simon C. Watkins, Melissa H. Little, Benjamin D. Humphreys, Samira Kiani, Alan Watson, Donna B. Stolz, Alan J. Davidson, Tom Carroll, Ondine Cleaver, Sunder Sims-Lucas, Mo R. Ebrahimkhani, Neil A. Hukriede Kidney Int
  Vascularization plays a critical role in organ maturation and cell type development. Drug discovery, organ mimicry, and ultimately transplantation hinge on achieving robust vascularization of in vitro engineered organs. Here, focusing on human kidney organoids, we overcame this hurdle by (…) (Kidney International (2024))
• 00:00
  Imaging Kidney Inflammation Using An Oxidatively Activated MRI Probe - Ivy A. Rosales, Iris Yuwen Zhou, Ilknur Ay, Mozhdeh Sojoodi, Meghan E. Sise, Eric M. Gale Kidney Int
  Imaging tools for kidney inflammation could improve care for patients suffering inflammatory kidney diseases by lessening reliance on percutaneous biopsy or biochemical tests alone. During kidney inflammation, infiltration of myeloid immune cells generates a kidney microenvironment that is (…) (Kidney International (2024))

4 juin

Kidney Int http://www.kidney-international.org/

• 00:00
  The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference - Marina Vivarelli, Jonathan Barratt, Laurence H. Beck, Fadi Fakhouri, Daniel P. Gale, Elena Goicoechea de Jorge, Marta Mosca, Marina Noris, Matthew C. Pickering, Katalin Susztak, Joshua M. Thurman, Michael Cheung, Jennifer M. King, Michel Jadoul, Wolfgang C. Winkelmayer, Richard J.H. Smith, for Conference Participants Kidney Int
  Uncontrolled complement activation can cause or contribute to glomerular injury in multiple kidney diseases. Although complement activation plays a causal role in atypical hemolytic uremic syndrome and C3 glomerulopathy, over the past decade, a rapidly accumulating body of evidence has shown a (…) (Kidney International (2024))

1er juin

Kidney Int http://www.kidney-international.org/

• 00:00
  Characterizing the cellular and molecular landscape of mineralocorticoid action and antagonism in the kidney - Verónica Miguel, Tilman B. Drueke Kidney Int
  The mineralocorticoid hormone aldosterone plays a major role in sodium and potassium homeostasis and blood volume regulation. Aldosterone binds to the mineralocorticoid receptor (MR) in the cytosol, and this complex translocates into the nucleus and binds to DNA, regulating target gene (…) (Kidney International 105, 6 (2024))
• 00:00
  The tragedy of mitotic catastrophe in podocytes - Stuart J. Shankland, Behzad Najafian, Oliver Wessely Kidney Int
  In diabetic and nondiabetic glomerular disease, the magnitude of the reduction of podocyte numbers is a critical determinant in the development of glomerulosclerosis. Experimental studies show that a decline of podocyte numbers by 21%–40% leads to mild persistent proteinuria and focal segmental (…) (Kidney International 105, 6 (2024))
• 00:00
  Renal artery microaneurysms in antineutrophil cytoplasmic antibody–associated vasculitis - Jiale Tang, Zhou Xiao, Liang Liu, Xiaozhao Li Kidney Int
  A 61-year-old man presented to the emergency department with a 1-week history of low back pain. Three years prior, he had been diagnosed with myeloperoxidase–antineutrophil cytoplasmic-associated vasculitis, with normal kidney function, and had received term treatment with prednisone and (…) (Kidney International 105, 6 (2024))
• 00:00
  Diagnosis of pseudo-acute kidney injury: mesothelial cells in the urine - Satoshi Kurahashi, Naohiro Toda, Ryo Sato, Kyoka Fujita, Jun Takeoka, Akira Ishii, Masaaki Fujita, Toshiyuki Komiya Kidney Int
  A 79-year-old man with lung cancer treated with chemotherapy was admitted for acute kidney injury. One week before admission, the patient was aware of abdominal distension and difficulty urinating. Admission laboratory tests showed serum creatinine level of 8.92 mg/dl (baseline, 0.94 mg/dl), (…) (Kidney International 105, 6 (2024))
• 00:00
  Not too much, not too little—just the right amount: the story of YAP in the podocyte - Caitríona M. McEvoy, Darren A. Yuen Kidney Int
  Chen et al. identify dysregulation of the transcriptional activator Yes-associated protein in the podocytes of diabetic mouse and human kidneys. Podocyte Yes-associated protein deficiency led to downregulation of the key transcription factor Wilms’ tumor 1, and worsened podocyte injury in a (…) (Kidney International 105, 6 (2024))
• 00:00
  Prognostic implications of unbiased molecular categorization in kidney disease - Michael T. Eadon Kidney Int
  In this commentary, a novel approach to the reclassification of chronic kidney disease is reviewed. In the revisited study, the investigators identify 4 distinct subtypes of kidney disease derived from an unbiased self-organizing map of transcriptomic data from kidney biopsy samples. These (…) (Kidney International 105, 6 (2024))
• 00:00
  The authors reply - Boris Fehse, Nicola M. Tomas Kidney Int
  We thank Rovira et al.1 for their interest in our recent work.2 We fully agree that the use of chimeric autoantibody receptor (CAAR) cells, which specifically target pathogenic B-cell clones, represents a highly innovative therapeutic strategy for antibody-mediated diseases. In this direction, (…) (Kidney International 105, 6 (2024))
• 00:00
  Chimeric autoantibody receptor cell therapy for the treatment of membranous nephropathy - Jordi Rovira, Carolt Arana, Ainhoa Garcia-Busquets, Ilse Gille, Luís F. Quintana, Mirjam H.M. Heemskerk, Sebastiaan Heidt, Eduard Palou, Fritz Diekmann Kidney Int
  We read with interest the research letter by Seifert et al.1 recently published in Kidney International. They demonstrated the basic efficacy of PLA2R1- and THSD7A-based chimeric autoantibody receptor (CAAR) natural killer (NK) and T cells for the antigen-specific elimination of (…) (Kidney International 105, 6 (2024))
• 00:00
  The Case | An active injection drug user with a skin rash and kidney failure - Abraham W. Aron, Randy L. Luciano Kidney Int
  A 38-year-old man with active IV heroin use presented with progressive lethargy and an evolving rash on his extremities for 1 week. The patient was afebrile and hemodynamically stable. Examination revealed multiple, painful purpuric lesions on his fingertips with painful petechiae on his upper (…) (Kidney International 105, 6 (2024))
• 00:00
  SGLT2 inhibitors act as metabolic transducers to restore healthy nutrient deprivation and surplus signaling in the kidney - Shinji Kume, Milton Packer Kidney Int
  In the healthy adult kidney, cellular homeostasis is maintained by the balance between nutrient surplus and nutrient deprivation signaling.1 The primary nutrient deprivation signals are sirtuin 1 (SIRT1) and adenosine monophosphate protein kinase (AMPK), which are activated by low intracellular (…) (Kidney International 105, 6 (2024))
• 00:00
  Kidney protective mechanisms of SGLT2 inhibitors: evidence for a hemodynamic effect - Kevin Yau, David Z.I. Cherney, Daniël H. van Raalte, Britt E. Wever Kidney Int
  Sodium-glucose cotransporter-2 (SGLT2) inhibitors were introduced a decade ago for the treatment of type 2 diabetes (T2D) and have emerged as a key therapy for the treatment of chronic kidney disease (CKD). In trials with primary kidney end points, SGLT2 inhibitors reduced the composite of (…) (Kidney International 105, 6 (2024))
• 00:00
  Podocyte injury as a potential therapeutic target in IgA nephropathy: should pathology guide us? - Mark Haas Kidney Int
  The Oxford histopathologic classification (MEST-C: scores for lesions indicating active glomerular inflammation, mesangial [M] and endocapillary [E] hypercellularity as well as cellular or fibrocellular crescents [C], and for segmental glomerulosclerosis [S] and interstitial fibrosis and/or (…) (Kidney International 105, 6 (2024))
• 00:00
  Challenges in the development of novel methodologies for measuring glomerular filtration rate - Edward J. Johns Kidney Int
  Measurement of glomerular filtration rate (GFR) is crucial in assessing kidney function status. Estimating GFR using clearance methodologies is cumbersome, as plasma and urinary concentrations and timed urine collections are required. Recently, a transcutaneous sensor has been developed whereby (…) (Kidney International 105, 6 (2024))
• 00:00
  in this issue Kidney Int
  Lafayette et al. report on the progress of the ORIGIN trial (ClinicalTrials.gov: NCT04716231), a phase 2B study of atacicept for the treatment of IgA nephropathy (IgAN). Atacicept inhibits the B-cell survival factors B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL). (…) (Kidney International 105, 6 (2024))
• 00:00
  SGLT2 inhibitor: 2-way superstar in nephrology? - Masaomi Nangaku Kidney Int
  Shohei Ohtani became an amazing 2-way player in a modern-day game of baseball that basically never sees them, and he won his second American League most valuable player award unanimously in 2023. (Kidney International 105, 6 (2024))
• 00:00
  journal club Kidney Int
  Colombijn et al. (Representation of patients with chronic kidney disease in clinical trials of cardiovascular disease medications: a systematic review. JAMA Netw Open. 2024;7:e240427.) (Kidney International 105, 6 (2024))
• 00:00
  Corrigendum to “Are biomarkers in acute kidney injury ready for prime time? The time is right for a second look.” Kidney Int. 2024;105:675–678 - Chirag R. Parikh, Steven G. Coca Kidney Int
  DOI of original article: https://doi.org/10.1016/j.kint.2024.01.018 (Kidney International 105, 6 (2024))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 105, 6 (2024))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 105, 6 (2024))
• 00:00
  Table of Contents Kidney Int
  (Kidney International 105, 6 (2024))

29 mai

Kidney Int http://www.kidney-international.org/

• 00:00
  Signaling through cAMP-Epac1 induces metabolic reprogramming to protect podocytes in glomerulonephritis - Lilia Abbad, Maximin Détrait, Panagiotis Kavvadas, Dorian Bergonnier, Lisa Melis, Marion Laudette, Tiffany Migeon, Marie-Christine Verpont, Alexandre Lucas, Christos Chatziantoniou, Frank Lezoualc’h Kidney Int
  Unlike classical protein kinase A, with separate catalytic and regulatory subunits, EPACs are single chain multi-domain proteins containing both catalytic and regulatory elements. The importance of cAMP-Epac-signaling as an energy provider has emerged over the last years. However, little is (…) (Kidney International (2024))
• 00:00
  Platelets, inflammation, and purinergic receptors in chronic kidney disease - Adam L. Corken, Vincz Ong, Rajshekhar Kore, Sai N. Ghanta, Oleg Karaduta, Rupak Pathak, Shannon Rose, Craig Porter, Nishank Jain Kidney Int
  Platelets are anucleated cells that circulate in the bloodstream. Historically, platelets were thought to perform a singular function—stop bleeding via clotting. Although platelets do play a key role in hemostasis and thrombosis, recent studies indicate that platelets also modulate inflammation, (…) (Kidney International (2024))
• 00:00
  Identification of the gut microbial enzyme turning the urine yellow - Marianne Harvent, Olivier Devuyst Kidney Int
  For ages, the transparency, smell, color, and even taste of urine have been scrutinized by physicians and laypeople willing to understand disease and to make a diagnosis. Some of these associations have stood the test of time. The color of urine, in particular, is still considered as a valuable (…) (Kidney International (2024))