6 juillet

Kidney Int http://www.kidney-international.org/

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  B-cell repertoire and functions in idiopathic nephrotic syndrome: what to learn from single-cell RNA-sequencing? - Guillaume Dorval, Manuela Colucci, Olivia Boyer Kidney Int
  Idiopathic nephrotic syndrome (INS) is the most common glomerular nephropathy in children. The most frequent histological pattern is “minimal change disease”, characterized by normal kidney on light microscopy, with no deposits on immunofluorescence, and with effacement of podocyte foot (…) (Kidney International (2024))

3 juillet

Kidney Int http://www.kidney-international.org/

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  Clinical trial designs to assess treatment effects on glomerular filtration rate decline. - Hiddo J.L. Heerspink, Dustin J. Little, Lars Frison, Samvel B. Gasparyan, Christoph Wanner, Niels Jongs, D. Postmus Kidney Int
  Glomerular filtration rate (GFR) decline is used as surrogate endpoint for kidney failure. Interventions that reduce chronic kidney disease (CKD) progression often exert acute GFR reductions which differ from their long-term benefits and complicate the estimation of long-term benefit. Here, we (…) (Kidney International (2024))

2 juillet

Kidney Int http://www.kidney-international.org/

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  Clinical validation of the novel fluorescent glomerular filtration rate tracer agent relmapirazin (MB-102) - Richard B. Dorshow, Martin P. Debreczeny, Stuart L. Goldstein, Jeng-Jong Shieh Kidney Int
  The fluorescent compound relmapirazin has been rationally designed for use in point-of-care measurement of glomerular filtration rate (GFR), with attributes including negligible protein binding, negligible metabolites in vivo, negligible tubular secretion, and excellent chemical and photo (…) (Kidney International (2024))

1er juillet

Kidney Int http://www.kidney-international.org/

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  The randomized controlled trial (NAVKIDS2) of a patient navigator program created for children with chronic kidney disease. - Germaine Wong, Chandana Guha, Kylie-Ann Mallitt, Anita van Zwieten, Rabia Khalid, Anna Francis, Allison Jaure, Siah Kim, Armando Teixeira-Pinto, Martha Aquino, Amelie Bernier-Jean, David W. Johnson, Deirdre Hahn, Donna Reidlinger, Elizabeth G. Ryan, Fiona Mackie, Hugh McCarthy, Julie Varghese, Charani Kiriwandeniya, Kirsten Howard, Nicholas Larkins, Luke Macauley, Amanda Walker, Martin Howell, Patrina Caldwell, Reginald Woodleigh, Shilpa Jesudason, Simon Carter, Sean Kennedy, Stephen Alexander, Steve McTaggart, Jonathan C. Craig, Carmel M. Hawley, NAVKIDS2 trial steering committee Kidney Int
  Patient navigators enable adult patients to circumnavigate complex health systems, improving access to health care and outcomes. Here, we aimed to evaluate the effects of a patient navigation program in children with chronic kidney disease (CKD). In this multi-center, randomized controlled (…) (Kidney International (2024))
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  MRI findings of renal cortical hemosiderosis after cardiac valve surgery - Haijuan Lv, Hongwei Zhao Kidney Int
  A 74-year-old female patient, at 9 years post mitral and tricuspid valve repairs with C-shaped annuloplasty rings, presented with proteinuria (2+) and anemia (Hb 97 g/l), and elevated lactate dehydrogenase levels at 845 U/L (reference range: 120–250 U/L), indicative of intravascular hemolysis. (…) (Kidney International 106, 1 (2024))
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  Solitary kidney in a patient with Pallister-Hall syndrome - Ines Vanderheyden, Saskia Bulk, François Jouret Kidney Int
  A 58-year-old female patient was referred for solitary kidney management. She was born following a full-term pregnancy, with a weight of 2.2 kg. Her medical history included the following: (i) “Y-shaped metacarpals” and postaxial polydactyly (15 fingers in toto) bilaterally operated (Figure 1); (…) (Kidney International 106, 1 (2024))
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  Taking the amphoterism out of amphotericin: a wonder drug in the making - Andrew Beenken Kidney Int
  Invasive fungal infections number up to 1,000,000 cases per year,1 and an increasing number exhibit multidrug resistance. Amphotericin B has been an important tool in fighting these infections ever since the 1950s when it was first isolated from the soil of the Orinoco basin in Venezuela.2 (…) (Kidney International 106, 1 (2024))
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  Inflammasome activation: unraveling the link between chronic kidney disease and atrial fibrillation - Melis Sahinoz, T. Alp Ikizler Kidney Int
  Atrial fibrillation (AF) is the most common cardiac arrhythmia, currently affecting ?60 million people worldwide, and it is associated with significant morbidity and mortality.1 Chronic kidney disease (CKD) is an independent risk factor for incident and prevalent AF, with a stepwise increase in (…) (Kidney International 106, 1 (2024))
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  Corrigendum to “Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax.” Kidney International 2023;103:115–133 - Jingyao Li, Xi’ang Sun, Ninghao Yang, Jiayun Ni, Hongyan Xie, Hengjiang Guo, Xin Wang, Li Zhou, Jun Liu, Sijia Chen, Xiaoxia Wang, Yingying Zhang, Chen Yu, Wei Zhang, Limin Lu Kidney Int
  DOI of original article: https://doi.org/10.1016/j.kint.2022.08.022 (Kidney International 106, 1 (2024))
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  Corrigendum to “Kidney involvement in Rosai-Dorfman disease.” Kidney International 2023;103:231–232 - Martina Mazzariol, Francesco Peyronel, Filippo Fagni, Andrea Minervini, Raffaella Santi, Simone Agostini, Augusto Vaglio Kidney Int
  DOI of original article: 10.1016/j.kint.2022.09.005 (Kidney International 106, 1 (2024))
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  Foscarnet-induced nephropathy in a kidney transplant recipient - Ian P. Rios, Christian H.L. Nguyen, Suman S. Misra, Margaret S. Ryan, Sumi S. Nair, Hasan A. Khamash Kidney Int
  A 53-year-old man with type 2 diabetes–related kidney failure underwent cytomegalovirus (CMV)–mismatched (CMV positive to negative), deceased donor kidney transplant in July 2021. He was on a prophylactic dose of valganciclovir until September 2021 when he developed neutropenia, and (…) (Kidney International 106, 1 (2024))
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  The Case | Rapid onset of severe hyponatremia after a dental procedure - Laura Scholz, Max Schuller, Michael Kolland, Philipp Eller, Alexander H. Kirsch Kidney Int
  A 38-year-old woman presented at a peripheral hospital for progressive abdominal pain, nausea, and vomiting. Except for a 7-day course of antibiotic treatment following a dental procedure performed a few days before symptom onset, she had not been on any medication. Her medical history was not (…) (Kidney International 106, 1 (2024))
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  Editorial Board Kidney Int
  (Kidney International 106, 1 (2024))
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  Erratum to “An update on clinical presentation and responses to therapy of patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH).” Kidney International 2023;105:1058–1076 - Zewu Zhu, Bryan Bo-Ran Ho, Alyssa Chen, James Amrhein, Andreea Apetrei, Thomas Oliver Carpenter, Marise Lazaretti-Castro, Juan Manuel Colazo, Kathryn McCrystal Dahir, Michaela Geßner, Evgenia Gurevich, Cathrine Alsaker Heier, Jill Hickman Simmons, Tracy Earl Hunley, Bernd Hoppe, Christina Jacobsen, Anne Kouri, Nina Ma, Sachin Majumdar, Arnaud Molin, Natalie Nokoff, Susan M. Ott, Helena Gil Peña, Fernando Santos, Peter Tebben, Lisa Swartz Topor, Yanhong Deng, Clemens Bergwitz Kidney Int
  The publisher regrets that the definition of het-post (post-treatment levels of het carriers) was not included in the legends of Figure 3 and Supplementary Figure S3, and that descriptions of upper limit (%UL) and/or z-score were not included in the legends of Supplementary Figures S2–S4, S6, (…) (Kidney International 106, 1 (2024))
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  Preventing MMP23-mediated cleavage of podocyte RARRES1: a novel strategy to halt chronic kidney disease progression? - Paulina X. Medina Rangel, Shuta Ishibe Kidney Int
  Glomerular issues and affected podocytes are at the origin of 80% of chronic kidney disease cases. Thus, acquiring a deeper understanding in this domain is necessary to halt progressive kidney damage. In this study, the authors investigated the harmful impact of podocyte-cleaved soluble retinoic (…) (Kidney International 106, 1 (2024))
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  Genomics in the kidney transplant clinic: the future standard of care? - Emilie Cornec-Le Gall, Andrew J. Mallett Kidney Int
  New evidence indicates potential benefit of genomics to illuminate nonkidney monogenic morbidity and mortality risk among kidney transplant recipients. This might be of direct relevance to an equivalent proportion of patients to those who harbor a monogenic kidney disease. Further evidence and (…) (Kidney International 106, 1 (2024))
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  journal club Kidney Int
  Verma et al. (Ann Intern Med. 2024;177:467–475.) (Kidney International 106, 1 (2024))
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  in this issue Kidney Int
  Asowata and colleagues studied deceased donor transplant kidneys with impaired kidney function as a model of acute and chronic kidney injury using an integrated multi-omic approach. RNA sequencing demonstrated that T cell and macrophage tissue infiltration associated with changes in both donors’ (…) (Kidney International 106, 1 (2024))
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  Factor XI inhibition in hemodialysis patients: the safer anticoagulation? - Eleni Stamellou, Heidi Noels, Jürgen Floege Kidney Int
  Chronic hemodialysis patients exhibit an excessive cardiovascular risk and a marked increase in both thromboembolism and bleeding episodes. Factor XI inhibition may provide anticoagulation, with a low risk of bleeding, and several factor XI inhibitors, including fesomersen, an antisense (…) (Kidney International 106, 1 (2024))
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  Table of Contents Kidney Int
  (Kidney International 106, 1 (2024))
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  Subscription Information Kidney Int
  (Kidney International 106, 1 (2024))

28 juin

Kidney Int http://www.kidney-international.org/

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  An observational cohort study examined the change point of kidney function stabilization in the initial period after transplantation. - Evert Cleenders, Maarten Coemans, Soufian Meziyerh, Jasper Callemeyn, Marie-Paule Emonds, Wilfried Gwinner, Jesper Kers, Dirk Kuypers, Irina Scheffner, Aleksandar Senev, Elisabet Van Loon, Karolien Wellekens, Aiko P.J. de Vries, Geert Verbeke, Maarten Naesens Kidney Int
  Baseline kidney function following kidney transplantation is often used in research and clinical decision-making yet is not well defined. Here, a method to determine baseline function was proposed and validated on three single-center retrospective cohorts consisting of 922 patients from Belgium (…) (Kidney International (2024))

27 juin

Kidney Int http://www.kidney-international.org/

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  Targeted RNAseq from patients’ urinary cells to validate pathogenic non coding variants in Autosomal Dominant Polycystic Kidney Disease genes: a proof of concept. - Guillaume Dorval, Gérald Le Gac, Vincent Morinière, Chandran Ka, Claire Goursaud, Bertrand Knebelmann, Pierre Marijon, Sophie Nambot, Nicolas Cagnard, Patrick Nitschké, Laurence Michel-Calemard, Marie-Pierre Audrézet, Laurence Heidet Kidney Int
  Genetic testing remains unconclusive in 7-10% of families affected with autosomal dominant polycystic kidney disease (ADPKD), despite thorough sequencing of all known exons of PKD1 and PKD2, the two major ADPKD genes, and of other genes involved such as IFT140, GANAB, DNAJB11, ALG5, ALG8, ALG9, (…) (Kidney International (2024))

18 juin

Kidney Int http://www.kidney-international.org/

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  Imaging kidney inflammation using an oxidatively activated MRI probe - Ivy A. Rosales, Iris Yuwen Zhou, Ilknur Ay, Mozhdeh Sojoodi, Meghan E. Sise, Eric M. Gale Kidney Int
  Imaging tools for kidney inflammation could improve care for patients suffering inflammatory kidney diseases by lessening reliance on percutaneous biopsy or biochemical tests alone. During kidney inflammation, infiltration of myeloid immune cells generates a kidney microenvironment that is (…) (Kidney International (2024))
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  A meta-analysis of randomized controlled clinical trials for implications of acute treatment effects on glomerular filtration rate for long-term kidney protection - Hiddo J.L. Heerspink, Devin Eddington, Juhi Chaudhari, Raymond Estacio, Enyu Imai, Marian Goicoechea, Thierry Hannedouche, Richard Haynes, Tazeen H. Jafar, David W. Johnson, Rob C.M. van Kruijsdijk, Julia B. Lewis, Philip K.T. Li, Brendon L. Neuen, Ronald D. Perrone, Piero Ruggenenti, Christoph Wanner, Mark Woodward, Di Xie, Tom Greene, Lesley A. Inker Kidney Int
  Pharmacologic interventions to slow chronic kidney disease progression, such as ACE-inhibitors, angiotensin receptor blockers, or sodium glucose co-transporter 2 inhibitors, often produce acute treatment effects on glomerular filtration rate (GFR) that differ from their long-term chronic (…) (Kidney International (2024))
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  A genetically inducible endothelial niche enables vascularization of human kidney organoids with multilineage maturation and emergence of renin expressing cells - Joseph C. Maggiore, Ryan LeGraw, Aneta Przepiorski, Jeremy Velazquez, Christopher Chaney, Thitinee Vanichapol, Evan Streeter, Zainab Almuallim, Akira Oda, Takuto Chiba, Anne Silva-Barbosa, Jonathan Franks, Joshua Hislop, Alex Hill, Haojia Wu, Katherine Pfister, Sara E. Howden, Simon C. Watkins, Melissa H. Little, Benjamin D. Humphreys, Samira Kiani, Alan Watson, Donna B. Stolz, Alan J. Davidson, Tom Carroll, Ondine Cleaver, Sunder Sims-Lucas, Mo R. Ebrahimkhani, Neil A. Hukriede Kidney Int
  Vascularization plays a critical role in organ maturation and cell-type development. Drug discovery, organ mimicry, and ultimately transplantation hinge on achieving robust vascularization of in vitro engineered organs. Here, focusing on human kidney organoids, we overcame this hurdle by (…) (Kidney International (2024))
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  Effects of microplastics on the kidneys: a narrative review - Rodrigo Bueno de Oliveira, Lauter E. Pelepenko, Daniela A. Masaro, Glauco M.M.M. Lustosa, Mariana Cassani, Noemí A.V. Roza, Marina A. Marciano, Luciene M. dos Reis, Saïd Kamel, Loïc Louvet, Talita Mazon Kidney Int
  Microplastics (MPs) and nanoplastics are small synthetic organic polymer particles ( (Kidney International (2024))