26 juin

Circulation http://ahajournals.org/

• 06:30
  Implementation of First-trimester Screening and Prevention of Preeclampsia: a Stepped Wedge Cluster-randomized Trial in Asia - Long Nguyen-Hoang Linh Thuy Dinh Angela S.T. Tai Duy-Anh Nguyen Ritsuko K. Pooh Arihiro Shiozaki Mingming Zheng Yali Hu Bin Li Raden Aditya Kusuma Piengbulan Yapan Arundhati Gosavi Mayumi Kaneko Suchaya Luewan Tung-Yao Chang Noppadol Chaiyasit Tongta Nanthakomon Huishu Liu Steven W. Shaw Wing Cheong Leung Zaleha Abdullah Mahdy Angela Aguilar Hillary H.Y. Leung Nikki M.W Lee So Ling Lau Isabella Y.M. Wah Xiaohong Lu Daljit S. Sahota Marc K.C. Chong Liona C. Poon Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China (…) Circulation
  Circulation, Ahead of Print. Background: This trial aimed to assess the efficacy, acceptability and safety of a first-trimester screen-and-prevent strategy for preterm preeclampsia (PE) in Asia.Methods: Between 1stAugust 2019 and 28thFebruary 2022, this multicenter stepped wedge cluster (…) (Circulation)

24 juin

Circulation http://ahajournals.org/

• 11:00
  Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation - Funsho E. Fakuade Dominik Hubricht Vanessa Möller Izzatullo Sobitov Aiste Liutkute Yannic Döring Fitzwilliam Seibertz Marcus Gerloff Julius Ryan D. Pronto Fereshteh Haghighi Sören Brandenburg Khaled Alhussini Nadezda Ignatyeva Yara Bonhoff Stefanie Kestel Aschraf El-Essawi Ahmad Fawad Jebran Marius Großmann Bernhard C. Danner Hassina Baraki Constanze Schmidt Samuel Sossalla Ingo Kutschka Constanze Bening Christoph Maack Wolfgang A. Linke Jordi Heijman Stephan E. Lehnart George Kensah Antje Ebert Fleur E. Mason Niels Voigt Institute of Pharmacology and Toxicology, Georg-August-University (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Alterations in the buffering of intracellular Ca2+, for which myofilament proteins play a key role, have been shown to promote cardiac arrhythmia. It is interesting that although studies report atrial myofibrillar degradation in patients with persistent (…) (Circulation)

20 juin

Circulation http://ahajournals.org/

• 11:00
  CYP2C19 Genetic Testing for Oral P2Y12 Inhibitor Therapy: A Scientific Statement From the American Heart Association - Naveen L. Pereira Sharon Cresci Dominick J. Angiolillo Wayne Batchelor Quinn Capers Larisa H. Cavallari Dana Leifer Jasmine A. Luzum Dan M. Roden Konstantinos Stellos Stephanie L. Turrise Sony Tuteja Circulation
  Circulation, Ahead of Print. There is significant variability in the efficacy and safety of oral P2Y12 inhibitors, which are used to prevent ischemic outcomes in common diseases such as coronary and peripheral arterial disease and stroke. Clopidogrel, a prodrug, is the most used oral P2Y12 (…) (Circulation)

19 juin

Circulation http://ahajournals.org/

• 11:00
  Dietary Acculturation Is Associated With Altered Gut Microbiome, Circulating Metabolites, and Cardiovascular Disease Risk in US Hispanics and Latinos: Results From HCHS/SOL - Yi Wang Guo-Chong Chen Zheng Wang Kai Luo Yanbo Zhang Yang Li Amanda C. McClain Marta M. Jankowska Krista M. Perreira Josiemer Mattei Carmen R. Isasi Maria M. Llabre Bharat Thyagarajan Martha L. Daviglus Linda Van Horn David Goldsztajn Farelo Luis E. Maldonado Steven R. Levine Bing Yu Eric Boerwinkle Rob Knight Robert D. Burk Robert C. Kaplan Qibin Qi Brandilyn A. Peters Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (Y.W., G.-C.C., Z.W., K.L., Y.Z., Y.L., C.R.I., R.D.B., R.C.K., Q.Q., B.A.P.). Department of Nutrition and Food Hygiene, (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Dietary acculturation, or adoption of dominant culture diet by migrant groups, influences human health. We aimed to examine dietary acculturation and its relationships with cardiovascular disease (CVD), gut microbiota, and blood metabolites among US (…) (Circulation)
• 11:00
  Childhood Opportunity and Acute Interstage Outcomes: A National Pediatric Cardiology Quality Improvement Collaborative Analysis - Benjamin Zielonka Emily M. Bucholz Minmin Lu Katherine E. Bates Garick D. Hill Nelangi M. Pinto Lynn A. Sleeper David W. Brown Department of Cardiology, Boston Children’s Hospital and Department of Pediatrics, Harvard Medical School, MA (B.Z., M.L., L.A.S., D.W.B.). Children’s Hospital Colorado, University of Colorado, Denver (E.M.B.). C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor (K.E.B.). Cincinnati Children’s Hospital Medical Center, OH (G.D.H.). Seattle Children’s Hospital, University of Washington, WA (N.M.P.). Circulation
  Circulation, Ahead of Print. BACKGROUND:The interstage period after discharge from stage 1 palliation carries high morbidity and mortality. The impact of social determinants of health on interstage outcomes is not well characterized. We assessed the relationship between childhood opportunity and (…) (Circulation)

17 juin

Circulation http://ahajournals.org/

• 11:00
  Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association - Aeron M. Small Katherine E. Yutzey Bryce A. Binstadt Kaitlin Voigts Key Nabila Bouatia-Naji David Milan Elena Aikawa Catherine M. Otto Cynthia St. Hilaire Circulation
  Circulation, Ahead of Print. Valvular heart disease is a common cause of morbidity and mortality worldwide and has no effective medical therapy. Severe disease is managed with valve replacement procedures, which entail high health care–related costs and postprocedural morbidity and mortality. (…) (Circulation)
• 11:00
  Novel Mouse Model of Myocardial Infarction, Plaque Rupture, and Stroke Shows Improved Survival With Myeloperoxidase Inhibition - Sohel Shamsuzzaman Rebecca A. Deaton Anita Salamon Heather Doviak Vlad Serbulea Victoria M. Milosek Megan A. Evans Santosh Karnewar Subhi Saibaba Gabriel F. Alencar Laura S. Shankman Kenneth Walsh Stefan Bekiranov Olivier Kocher Monty Krieger Bengt Kull Marie Persson Erik Michaëlsson Nils Bergenhem Sepideh Heydarkhan-Hagvall Gary K. Owens Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville. (S. Shamsuzzaman, R.A.D., A.S., V.S., V.M.M., S.K. S. Saibaba, L.S.S., G.K.O.) Department of Biochemistry and Molecular Genetics, University of (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Thromboembolic events, including myocardial infarction (MI) or stroke, caused by the rupture or erosion of unstable atherosclerotic plaques are the leading cause of death worldwide. Although most mouse models of atherosclerosis develop lesions in the aorta (…) (Circulation)
• 11:00
  Deep Learning for Echo Analysis, Tracking, and Evaluation of Mitral Regurgitation (DELINEATE-MR) - Aaron Long Christopher M. Haggerty Joshua Finer Dustin Hartzel Linyuan Jing Azadeh Keivani Christopher Kelsey Daniel Rocha Jeffrey Ruhl David vanMaanen Gil Metser Eamon Duffy Thomas Mawson Mathew Maurer Andrew J. Einstein Ashley Beecy Deepa Kumaraiah Shunichi Homma Qi Liu Vratika Agarwal Mark Lebehn Martin Leon Rebecca Hahn Pierre Elias Timothy J. Poterucha Seymour, Paul, and Gloria Milstein Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center/New York–Presbyterian Hospital, NY (A.L., G.M., E.D., T.M., M.M., A.J.E., D.K., S.H., Q.L., V.A., M. Lebehn, M. (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Artificial intelligence, particularly deep learning (DL), has immense potential to improve the interpretation of transthoracic echocardiography (TTE). Mitral regurgitation (MR) is the most common valvular heart disease and presents unique challenges for (…) (Circulation)
• 11:00
  Induction of DEPP1 by HIF Mediates Multiple Hallmarks of Ischemic Cardiomyopathy - Gregory A. Wyant Qinqin Jiang Madhu Singh Shariq Qayyum Clara Levrero Bradley A. Maron William G. Kaelin Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (G.A.W., Q.J., C.L., W.G.K.). Department of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. (B.A.M.) Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. (W.G.K.) Massachusetts General Hospital, Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Harvard Medical School, Charlestown (G.A.W., M.S., S.Q.). (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:HIF (hypoxia inducible factor) regulates many aspects of cardiac function. We and others previously showed that chronic HIF activation in the heart in mouse models phenocopies multiple features of ischemic cardiomyopathy in humans, including mitochondrial (…) (Circulation)
• 08:00
  Response by Jeong et al to Letter Regarding Article, “Early Left Ventricular Unloading or Conventional Approach After Venoarterial Extracorporeal Membrane Oxygenation: The EARLY-UNLOAD Randomized Clinical Trial” - In-Seok Jeong Min Chul Kim Yongwhan Lim Youngkeun Ahn Department of Thoracic and Cardiovascular Surgery (I.-S.J.). Division of Cardiology, Department of Internal Medicine (M.C.K., Y.L., Y.A.), Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea. Circulation
  Circulation, Volume 149, Issue 25, Page e1417-e1417, June 18, 2024. (Circulation)
• 08:00
  Effects of Dapagliflozin on Body Composition and Its Relation to Hemodynamics in Heart Failure With Preserved Ejection Fraction - Jwan A. Naser Atsushi Tada Tomonari Harada Yogesh N.V. Reddy Rickey E. Carter Jeffrey M. Testani Michael D. Jensen Barry A. Borlaug Department of Cardiovascular Medicine (J.A.N., A.T., T.H., Y.N.V.R., B.A.B.), Mayo Clinic, Rochester, MN. Department of Medicine, Division of Endocrinology, Diabetes and Metabolism (M.D.J.), Mayo Clinic, Rochester, MN. Department of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Jacksonville, FL (R.E.C.). Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New (…) Circulation
  Circulation, Volume 149, Issue 25, Page 2026-2028, June 18, 2024. (Circulation)
• 08:00
  Legend of MERLIN and the Quest for Cardiac Lineage Commitment - Rich Gang Li James F. Martin Cardiomyocyte Renewal Laboratory (R.G.L., J.F.M.), Houston. McGill Gene Editing Laboratory, Texas Heart Institute (R.G.L., J.F.M.), Houston. Department of Integrative Physiology (J.F.M.), Houston, TX. Center for Organ Repair and Renewal, Baylor College of Medicine (J.F.M.), Houston, TX. Circulation
  Circulation, Volume 149, Issue 25, Page 1980-1981, June 18, 2024. (Circulation)
• 08:00
  Letter by Jha Regarding Article, “Early Left Ventricular Unloading or Conventional Approach After Venoarterial Extracorporeal Membrane Oxygenation: The EARLY-UNLOAD Randomized Clinical Trial” - Ajay Kumar Jha Department of Anaesthesiology and Critical Care, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India. Circulation
  Circulation, Volume 149, Issue 25, Page e1415-e1416, June 18, 2024. (Circulation)
• 08:00
  Trajectories in Cardiac Aging: Journey to the Crossroads of Inflammation and Metabolism - Geneviève Derumeaux Daigo Sawaki Gabor Czibik Institut Mondor de Recherche Biomédicale, Institut national de la santé et de la recherche médicale U955, Université Paris Est Créteil (UPEC), AP-HP, Department of Physiology, Henri Mondor Hospital, FHU SENEC, Créteil, France (G.D., D.S., G.C.). Jichi Medical University, Department of Clinical Pharmacology and Cardiology, 3311-1 Shimotsuke-city, Tochigi-prefecture, Japan (D.S.). Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, (…) Circulation
  Circulation, Volume 149, Issue 25, Page 1935-1937, June 18, 2024. (Circulation)
• 08:00
  Numbing the Heart to Death: A Cautionary Tale About an In-Vogue Preoperative Analgesic - Benjamin B. Holmes Katherine T. Murray William G. Stevenson University of South Carolina School of Medicine Greenville (B.B.H.) Vanderbilt Heart and Vascular Institute (K.T.M., W.G.S.), Vanderbilt University School of Medicine, Nashville, TN Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN (K.T.M.). Circulation
  Circulation, Volume 149, Issue 25, Page 2021-2025, June 18, 2024. (Circulation)
• 08:00
  Advanced Cardiac Patches for the Treatment of Myocardial Infarction - Tailuo Liu Ying Hao Zixuan Zhang Hao Zhou Shiqin Peng Dingyi Zhang Ka Li Yuwen Chen Mao Chen Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases (T.L., Y.H., H.Z., S.P., D.Z., Y.C., M.C.), West China Hospital, Sichuan University, Chengdu, PR China. Department of Cardiology (T.L., S.P., D.Z., M.C.), West China Hospital, Sichuan University, Chengdu, PR China. Medicine and Engineering Interdisciplinary Research Laboratory of Nursing & Materials, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, PR China (T.L., (…) Circulation
  Circulation, Volume 149, Issue 25, Page 2002-2020, June 18, 2024. Myocardial infarction is a cardiovascular disease characterized by a high incidence rate and mortality. It leads to various cardiac pathophysiological changes, including ischemia/reperfusion injury, inflammation, fibrosis, and (…) (Circulation)

14 juin

Circulation http://ahajournals.org/

• 11:00
  Endothelial Heterogeneity in the Response to Autophagy Drives Small Vessel Muscularization in Pulmonary Hypertension - Qi Zhang Nobuhiro Yaoita Arata Tabuchi Shaofei Liu Shiau-Haln Chen Qiuhua Li Niklas Hegemann Caihong Li Julie Rodor Sara Timm Hebatullah Laban Toren Finkel Troy Stevens Diego F. Alvarez Lasti Erfinanda Marc de Perrot Mariya M. Kucherenko Christoph Knosalla Matthias Ochs Stefanie Dimmeler Thomas Korff Subodh Verma Andrew H. Baker Wolfgang M. Kuebler Institute of Physiology, Charité–Universitätsmedizin, Berlin, Germany. (Q.Z., N.Y., A.T., S.L., Q.L., N.H., C.L., L.E., M.M.K., W.M.K.) Core Facility Electron Microscopy, Charité–Universitätsmedizin, Berlin, Germany. (S.T., M.O.) Institute of (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Endothelial cell (EC) apoptosis and proliferation of apoptosis-resistant cells is a hallmark of pulmonary hypertension (PH). Yet, why some ECs die and others proliferate and how this contributes to vascular remodeling is unclear. We hypothesized that this (…) (Circulation)
• 11:00
  Randomized Trial for Evaluation in Secondary Prevention Efficacy of Combination Therapy–Statin and Eicosapentaenoic Acid (RESPECT-EPA) - Katsumi Miyauchi Hiroshi Iwata Yuji Nishizaki Teruo Inoue Atsushi Hirayama Kazuo Kimura Yukio Ozaki Toyoaki Murohara Kenji Ueshima Yoshihiro Kuwabara Sachiko Tanaka-Mizuno Naotake Yanagisawa Tosiya Sato Hiroyuki Daida Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan (K.M., H.I., Y.N., H.D.). Japan Red Cross Society, Nasu Red Cross Hospital, Otawara, Tochigi (T.I.). Dokkyo Medical University, Mibu, Tochigi, Japan (T.I.). Osaka Anti-Tuberculosis Association, Osaka Fukujyuji Hospital, Japan (A.H.). Department of Cardiology, (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Low plasma levels of eicosapentaenoic acid (EPA) are associated with cardiovascular events. This trial aimed to assess the clinical benefits of icosapent ethyl in patients with coronary artery disease, a low EPA/arachidonic acid (AA) ratio, and statin (…) (Circulation)

11 juin

Circulation http://ahajournals.org/

• 11:00
  Predicting Out-of-Hospital Cardiac Arrest in the General Population Using Electronic Health Records - Jessica Perry Jennifer A. Brody Christine Fong Jacob E. Sunshine Vikas N. O’Reilly-Shah Michael R. Sayre Thomas D. Rea Noah Simon Ali Shojaie Nona Sotoodehnia Neal A. Chatterjee Department of Biostatistics, University of Washington, Seattle (J.P., N.S., A.S.) Cardiovascular Health Research Unit, University of Washington, Seattle (J.A.B., N.S., T.D.R.) Division of Cardiology, University of Washington, Seattle (N.A.C.) Department of Medicine, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle (C.F., J.E.S., V.N.O.) Department of Emergency Medicine (M.R.S.), WA (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:The majority of out-of-hospital cardiac arrests (OHCAs) occur among individuals in the general population, for whom there is no established strategy to identify risk. In this study, we assess the use of electronic health record (EHR) data to identify OHCA (…) (Circulation)

10 juin

Circulation http://ahajournals.org/

• 08:00
  Correction to: Status and Future Directions for Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Disease With and Without Pulmonary Hypertension: A Scientific Statement From the American Heart Association Circulation
  Circulation, Volume 149, Issue 24, Page e1412-e1412, June 11, 2024. (Circulation)
• 08:00
  Correction to: 2023 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces Circulation
  Circulation, Volume 149, Issue 24, Page e1411-e1411, June 11, 2024. (Circulation)
• 08:00
  Novel Mouse Model for Selective Tagging, Purification, and Manipulation of Cardiac Myofibroblasts - Vaibhao Janbandhu Vikram Tallapragada Jinyuan Vero Li Bharti Shewale Shila Ghazanfar Ralph Patrick Charles D. Cox Richard P. Harvey Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia (V.J., V.T., J.V.L., B.S., C.D.C., R.P.H.). School of Clinical Medicine (V.J., J.V.L., R.P.H.), UNSW Sydney, Kensington, NSW 2052, Australia. School of Biomedical Sciences (C.D.C), UNSW Sydney, Kensington, NSW 2052, Australia. School of Mathematics and Statistics, Charles Perkins Centre, and Sydney Precision Data Science Centre, University of Sydney, Camperdown 2006, Australia (S.G.). (…) Circulation
  Circulation, Volume 149, Issue 24, Page 1931-1934, June 11, 2024. (Circulation)
• 08:00
  Letter by Andreotti et al Regarding Article, “Inflammation and Cholesterol as Predictors of Cardiovascular Events Among 13 970 Contemporary High-Risk Patients With Statin Intolerance” - Felicita Andreotti Francesco Burzotta Aldo Pietro Maggioni Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (F.A., F.B.). CardioThoracic Department, Catholic University Medical School, Rome, Italy (F.A., F.B.). ANMCO Research Center, Heart Care Foundation, Florence, Italy (A.P.M.). Circulation
  Circulation, Volume 149, Issue 24, Page e1312-e1312, June 11, 2024. (Circulation)
• 08:00
  Fifty Years of Cardiovascular Magnetic Resonance: Continuing Evolution Toward the “One-Stop Shop” for Cardiovascular Diagnosis - W. Gregory Hundley VCU Pauley Heart Center, Division of Cardiology, Department of Internal Medicine at Virginia Commonwealth University (VCU), Richmond. Circulation
  Circulation, Volume 149, Issue 24, Page 1859-1861, June 11, 2024. (Circulation)
• 08:00
  PVC or Not PVC? That Is the Question - Pierre Groussin Alex Melot Raphaël P. Martins Univ Rennes, CHU Rennes, INSERM, LTSI–UMR 1099, France. Circulation
  Circulation, Volume 149, Issue 24, Page 1927-1930, June 11, 2024. (Circulation)
• 08:00
  Correction to: Predicting Benefit From Evolocumab Therapy in Patients With Atherosclerotic Disease: Using a Genetic Risk Score Circulation
  Circulation, Volume 149, Issue 24, Page e1414-e1414, June 11, 2024. (Circulation)
• 08:00
  Correction to: 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines Circulation
  Circulation, Volume 149, Issue 24, Page e1413-e1413, June 11, 2024. (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 149, Issue 24, Page 1921-1926, June 11, 2024. (Circulation)
• 08:00
  A Concept of “Athero-Oncology”: Tumor-Like Smooth Muscle Cells Drive Atherosclerosis - Payel Chatterjee Kathleen A. Martin Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT. Circulation
  Circulation, Volume 149, Issue 24, Page 1899-1902, June 11, 2024. (Circulation)

6 juin

Circulation http://ahajournals.org/

• 11:00
  LncRNA DCRT Protects Against Dilated Cardiomyopathy by Preventing NDUFS2 Alternative Splicing by Binding to PTBP1 - Hengzhi Du Yanru Zhao Jianpei Wen Beibei Dai Guo Hu Yufei Zhou Zhongwei Yin Nan Ding Huaping Li Jiahui Fan Xiang Nie Feng Wang Qian Liu Zheng Wen Gang Xu Dao Wen Wang Chen Chen Divisions of Cardiology and Nephrology (G.X.) Tongji Hospital, and Department of Forensic Medicine (Q.L.) Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (H.D., Y.Z., J.W., B.D., G.H., Y.Z., Z.Y., N.D., H.L., J.F., X.N., F.W., Z.W., D.W.W., C.C.). Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, China (H.D., Y.Z., J.W., B.D., G.H., Y.Z., (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Dilated cardiomyopathy is characterized by left ventricular dilation and continuous systolic dysfunction. Mitochondrial impairment is critical in dilated cardiomyopathy; however, the underlying mechanisms remain unclear. Here, we explored the (…) (Circulation)
• 11:00
  Effect of Sacubitril/Valsartan on Cognitive Function in Patients With Heart Failure With Preserved Ejection Fraction: A Prespecified Analysis of PARAGON-HF - Pooja Dewan Li Shen João Pedro Ferreira Pardeep S. Jhund Inder S. Anand Alvin Chandra Lu-May Chiang Brian Claggett Akshay S. Desai Jianjian Gong Carolyn S.P. Lam Martin P. Lefkowitz Aldo P. Maggioni Felipe Martinez Milton Packer Margaret M. Redfield Jean L. Rouleau Dirk J. van Veldhuisen Faiez Zannad Michael R. Zile Scott D. Solomon John J.V. McMurray BHF Cardiovascular Research Centre, University of Glasgow, UK (P.D., L.S., P.S.J., J.J.V.M.). School of Clinical Medicine, Hangzhou Normal University, China (L.S.). Centre d’Investigations Cliniques Plurithématique 1433 and Inserm U1116, CHRU (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:A hypothetical concern has been raised that sacubitril/valsartan might cause cognitive impairment because neprilysin is one of several enzymes degrading amyloid-? peptides in the brain, some of which are neurotoxic and linked to Alzheimer-type dementia. To (…) (Circulation)

5 juin

Circulation http://ahajournals.org/

• 11:00
  Aortic Valve Stenosis Causes Accumulation of Extracellular Hemoglobin and Systemic Endothelial Dysfunction - Christine Quast Florian Bönner Amin Polzin Verena Veulemans Ramesh Chennupati Isabella Gyamfi Poku Susanne Pfeiler Nicolas Kramser Magdalena Nankinova Nicole Staub Elric Zweck Juliane Jokiel Fabian Keyser Jasmina Hoffe Sven Witkowski Katrin Becker Pia Leuders Saif Zako Ralf Erkens Christian Jung Ulrich Flögel Tianai Wang Michael Neidlin Ulrich Steinseifer Sven Thomas Niepmann Sebastian Zimmer Norbert Gerdes Miriam M. Cortese-Krott Martin Feelisch Tobias Zeus Malte Kelm Department of Cardiology, Pulmonology and Vascular Medicine, University Hospital, Heinrich Heine University, Düsseldorf, (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Whether aortic valve stenosis (AS) can adversely affect systemic endothelial function independently of standard modifiable cardiovascular risk factors is unknown.METHODS:We therefore investigated endothelial and cardiac function in an experimental model of (…) (Circulation)
• 11:00
  IRE1? Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts - Chao Li Shiqian Li Guangyu Zhang Qinfeng Li Weidan Song Xiaoding Wang Jane A. Cook Miesje van der Stoel Bradley W. Wright Francisco Altamirano Erica L. Niewold Jungsoo Han Garrett Kimble Pengfei Zhang Xiang Luo Hery Urra Herman I. May Anwarul Ferdous Xue-Nan Sun Yingfeng Deng Elina Ikonen Claudio Hetz Randal J. Kaufman Kezhong Zhang Thomas G. Gillette Philipp E. Scherer Joseph A. Hill Jin Chen Zhao V. Wang Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas. (C.L., G.Z., Q.L., W.S., X.W., J.A.C., E.L.N., X.L., H.I.M., A.F., (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Cardiomyocyte growth is coupled with active protein synthesis, which is one of the basic biological processes in living cells. However, it is unclear whether the unfolded protein response transducers and effectors directly take part in the control of (…) (Circulation)

4 juin

Circulation http://ahajournals.org/

• 11:00
  Forecasting the Burden of Cardiovascular Disease and Stroke in the United States Through 2050—Prevalence of Risk Factors and Disease: A Presidential Advisory From the American Heart Association - Karen E. Joynt Maddox Mitchell S.V. Elkind Hugo J. Aparicio Yvonne Commodore-Mensah Sarah D. de Ferranti William N. Dowd Adrian F. Hernandez Olga Khavjou Erin D. Michos Latha Palaniappan Joanne Penko Remy Poudel Véronique L. Roger Dhruv S. Kazi Circulation
  Circulation, Ahead of Print. BACKGROUND:Cardiovascular disease and stroke are common and costly, and their prevalence is rising. Forecasts on the prevalence of risk factors and clinical events are crucial.METHODS:Using the 2015 to March 2020 National Health and Nutrition Examination Survey and (…) (Circulation)
• 11:00
  Forecasting the Economic Burden of Cardiovascular Disease and Stroke in the United States Through 2050: A Presidential Advisory From the American Heart Association - Dhruv S. Kazi Mitchell S.V. Elkind Anne Deutsch William N. Dowd Paul Heidenreich Olga Khavjou Daniel Mark Michael E. Mussolino Bruce Ovbiagele Sonali S. Patel Remy Poudel Ben Weittenhiller Tiffany M. Powell-Wiley Karen E. Joynt Maddox Circulation
  Circulation, Ahead of Print. BACKGROUND:Quantifying the economic burden of cardiovascular disease and stroke over the coming decades may inform policy, health system, and community-level interventions for prevention and treatment.METHODS:We used nationally representative health, economic, and (…) (Circulation)
• 11:00
  Predicting the Future Prevalence of Cardiovascular Disease: The Good, the Bad, the Known, and the Unknown - Andrew E. Moran Lee Goldman Columbia University Vagelos College of Physicians and Surgeons, New York, NY; Division of General Medicine, Columbia University Irving Medical Center, New York, NY Columbia University Vagelos College of Physicians and Surgeons, New York, NY; Division of Cardiology, Columbia University Irving Medical Center, New York, NY; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY Circulation
  Circulation, Ahead of Print. (Circulation)
• 11:00
  Projections of Soaring Costs Are a Call to Arms - Elizabeth A. Magnuson Saint Luke's Mid America Heart Institute, Kansas City, MO; University of Missouri-Kansas City, Kansas City, MO Circulation
  Circulation, Ahead of Print. (Circulation)

3 juin

Circulation http://ahajournals.org/

• 08:00
  Seeing is Believing: Muscleblind-like 1 Is Necessary For Mammalian Cardiomyocyte Maturation - Khalid B. Dar Shah R. Ali Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York, NY. Circulation
  Circulation, Volume 149, Issue 23, Page 1830-1832, June 4, 2024. (Circulation)
• 08:00
  Implanted Human Cardiac Spheroids Electrically Couple With Infarcted Swine Myocardium - Bijay Guragain Yuhua Wei Hanyu Zhang Asher Kahn-Krell Lei Ye Gregory P. Walcott Jack M. Rogers Jianyi (Jay) Zhang Department of Biomedical Engineering, School of Medicine and School of Engineering.(B.G., Y.W., H.Z., A.K.-K., L.Y., G.P.W., J.M.R., J.Z.). Department of Medicine/Cardiovascular Diseases (G.P.W., J.Z), University of Alabama at Birmingham. Circulation
  Circulation, Volume 149, Issue 23, Page 1855-1857, June 4, 2024. (Circulation)
• 08:00
  The Future of Clinical Trials - Faiez Zannad Bertram Pitt Université de Lorraine, INSERM Clinical Investigation Center at Institut Lorrain du Coeur et des Vaisseaux, University Hospital of Nancy, France (F.Z.). Division of Cardiology, University of Michigan School of Medicine, Ann Arbor (B.P.). Circulation
  Circulation, Volume 149, Issue 23, Page 1783-1785, June 4, 2024. (Circulation)
• 08:00
  Pharmacogenetic Influences Over Mavacamten Pharmacokinetics: Considerations for the Treatment of Individuals With Hypertrophic Cardiomyopathy - Kathryn A. McGurk Nagme Bilgehan James S. Ware National Heart and Lung Institute and MRC Laboratory of Medical Sciences, Imperial College London, UK (K.A.M., N.B., J.S.W.). Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA (K.A.M., J.S.W.). Imperial College Healthcare NHS Trust, London, UK (J.S.W.). Royal Brompton & Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London, UK (J.S.W.). Circulation
  Circulation, Volume 149, Issue 23, Page 1786-1788, June 4, 2024. (Circulation)
• 08:00
  A Wide Complex Tachycardia - Chan-Hee Lee Emily Higgs Melvin M. Scheinman Division of Cardiology, Department of Internal Medicine, Yeungnam University Medical Center, Daegu, Republic of Korea (C.-H.L.). Cardiovascular Genetics Program (E.H.), University of California San Francisco. Division of Cardiology, Section of Electrophysiology (M.M.S.), University of California San Francisco. Circulation
  Circulation, Volume 149, Issue 23, Page 1852-1854, June 4, 2024. (Circulation)

30 mai

Circulation http://ahajournals.org/

• 11:00
  Fostering Psychological Safety and Supporting Mental Health Among Cardiovascular Health Care Workers: A Science Advisory From the American Heart Association - Laxmi S. Mehta Keith Churchwell Dawn Coleman Judy Davidson Karen Furie Nkechinyere N. Ijioma Jason N. Katz Christine Moutier Jessica Y. Rove Richard Summers Alyssa Vela Tait Shanafelt Circulation
  Circulation, Ahead of Print. The psychological safety of health care workers is an important but often overlooked aspect of the rising rates of burnout and workforce shortages. In addition, mental health conditions are prevalent among health care workers, but the associated stigma is a (…) (Circulation)

29 mai

Circulation http://ahajournals.org/

• 11:00
  Cardiovascular Magnetic Resonance Radiomics to Identify Components of the Extracellular Matrix in Dilated Cardiomyopathy - Shiro Nakamori Amine Amyar Ahmed S. Fahmy Long H. Ngo Masaki Ishida Satoshi Nakamura Taku Omori Keishi Moriwaki Naoki Fujimoto Kyoko Imanaka-Yoshida Hajime Sakuma Kaoru Dohi Warren J. Manning Reza Nezafat Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA. (S. Nakamori, A.A., A.S.F., L.H.N., W.J.M., R.N.) Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA. (W.J.M.) Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan (S. Nakamura, T.O., K.M., N.F., (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Current cardiovascular magnetic resonance sequences cannot discriminate between different myocardial extracellular space (ECSs), including collagen, noncollagen, and inflammation. We sought to investigate whether cardiovascular magnetic resonance radiomics (…) (Circulation)
• 11:00
  Evaluation and Management of Chronic Heart Failure in Children and Adolescents With Congenital Heart Disease: A Scientific Statement From the American Heart Association - Shahnawaz Amdani Jennifer Conway Kristen George Hugo R. Martinez Alfred Asante-Korang Caren S. Goldberg Ryan R. Davies Shelley D. Miyamoto Daphne T. Hsu Circulation
  Circulation, Ahead of Print. With continued medical and surgical advancements, most children and adolescents with congenital heart disease are expected to survive to adulthood. Chronic heart failure is increasingly being recognized as a major contributor to ongoing morbidity and mortality in (…) (Circulation)

28 mai

Circulation http://ahajournals.org/

• 11:00
  Atorvastatin Effect on Aortic Dilatation and Valvular Calcification Progression in Bicuspid Aortic Valve (BICATOR): A Randomized Clinical Trial - Arturo Evangelista Laura Galian-Gay Andrea Guala Gisela Teixido-Tura Francisco Calvo-Iglesias Teresa Sevilla Javier Bermejo Irene Méndez Violeta Sánchez Juan M. Robredo Carmona Josep M. Alegret Elena Ferrer-Sistach Daniel Saura Aroa Ruiz-Muñoz Lydia Dux-Santoy María Ángeles Carmona Marina Huguet Hug Cuellar-Calabria Augusto Sao-Avilés Ignacio Ferreira-González Jose F. Rodríguez-Palomares Servei de Cardiologia (A.E., L.G.-G., G.T.-T., A.R.-M., M.A.C., H.C.-C., I.F.-G., J.F.R.-P.), Hospital Universitari Vall d´Hebron, Barcelona, Spain. Servei de Radiodiagnòstic (H.C.-C.), Hospital (…) Circulation
  Circulation, Volume 149, Issue 25, Page 1938-1948, June 18, 2024. BACKGROUND:Ascending aorta dilation and aortic valve degeneration are common complications in patients with bicuspid aortic valve. Several retrospective studies have suggested the benefit of statins in reducing these (…) (Circulation)
• 11:00
  Skeletal Muscle SIRT3 Deficiency Contributes to Pulmonary Vascular Remodeling in Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction - Jia-Rong Jheng Yang Bai Kentaro Noda Joshua R. Huot Todd Cook Amanda Fisher Yi-Yun Chen Dmitry A. Goncharov Elena A. Goncharova Marc A. Simon Yingze Zhang Daniel E. Forman Mauricio Rojas Roberto F. Machado Johan Auwerx Mark T. Gladwin Yen-Chun Lai Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis. (J.-R.J., Y.B., T.C., A.F., R.F.M., Y.-C.L.) Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis. (J.R.H., R.F.M., Y.-C.L.) Department of Clinical Pharmacology, School of (…) Circulation
  Circulation, Ahead of Print. BACKGROUND:Pulmonary hypertension (PH) is a major complication linked to adverse outcomes in heart failure with preserved ejection fraction (HFpEF), yet no specific therapies exist for PH associated with HFpEF (PH-HFpEF). We have recently reported on the role of (…) (Circulation)
• 08:00
  Centennial Collection: Health Applications of Digital Technologies - Seth S. Martin Digital Health Laboratory, Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD. American Heart Association Health Technologies and Innovation Strategically Focused Research Network, Johns Hopkins mTECH Center, Baltimore, MD. Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore, MD. Circulation
  Circulation, Volume 149, Issue 22, Page 1701-1703, May 28, 2024. (Circulation)
• 08:00
  Evolving Cardiac Safety in Drug Discovery: Time for Immunology Integration - Jose M. Vicencio Caroline R. Archer Amy Pointon Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom. Circulation
  Circulation, Volume 149, Issue 22, Page 1704-1707, May 28, 2024. (Circulation)
• 08:00
  Letter by Cardinale et al Regarding Article, “Multicenter, Prospective, Randomized Controlled Trial of High-Sensitivity Cardiac Troponin I–Guided Combination Angiotensin Receptor Blockade and Beta-Blocker Therapy to Prevent Anthracycline Cardiotoxicity: The Cardiac CARE Trial” - Daniela Cardinale Alexander R. Lyon Teresa López-Fernández Cardioncology Unit, European Institute of Oncology, IRCCS, Milan, Italy (D.C.). Cardio-Oncology Service, Royal Brompton & Harefield NHS Foundation Trust and the National Heart & Lung Institute, Imperial College London, UK (A.R.L.). Cardiology Department, La Paz University Hospital, IdiPAZ Research Institute, Madrid, Spain (T.L.-F.). Cardiology Department, Quiron Pozuelo University Hospital, Madrid, Spain (T.L.-F.). Circulation
  Circulation, Volume 149, Issue 22, Page e1219-e1220, May 28, 2024. (Circulation)
• 08:00
  Response by Henriksen et al Regarding Article, “Multicenter, Prospective, Randomized Controlled Trial of High-Sensitivity Cardiac Troponin I–Guided Combination Angiotensin Receptor Blockade and Beta-Blocker Therapy to Prevent Anthracycline Cardiotoxicity: The Cardiac CARE Trial” - Peter A. Henriksen Peter Hall Ninian N. Lang British Heart Foundation Centre for Cardiovascular Science (P.A.H.), University of Edinburgh, UK. Cancer Research UK – Edinburgh Centre (P.H.), University of Edinburgh, UK. Medical Research Council Institute Genetics and Molecular Medicine (P.H.), University of Edinburgh, UK. School of Cardiovascular and Metabolic Health, University of Glasgow, UK (N.N.L.). Circulation
  Circulation, Volume 149, Issue 22, Page e1221-e1222, May 28, 2024. (Circulation)
• 08:00
  MicroRNA-122–Mediated Liver Detargeting Enhances the Tissue Specificity of Cardiac Genome Editing - Luzi Yang Zhanzhao Liu Gonglie Chen Zhan Chen Congting Guo Xiangwen Ji Qinghua Cui Yueshen Sun Xiaomin Hu Yanjiang Zheng Yifei Li Fei Gao Liang Chen Pingzhu Zhou William T. Pu Yuxuan Guo School of Basic Medical Sciences and Institute of Cardiovascular Sciences (L.Y., Z.L., G.C., Z.C., C.G., Y.G.), Peking University Health Science Center, Beijing, China. School of Basic Medical Sciences Department of Biomedical Informatics, Center for Noncoding RNA Medicine (Q.C.), Peking University Health Science Center, Beijing, China. State Key Laboratory of Vascular Homeostasis and Remodeling, Peking (…) Circulation
  Circulation, Volume 149, Issue 22, Page 1778-1781, May 28, 2024. (Circulation)
• 08:00
  Extracellular Vesicles: Bridging the Heart and Tumor in Reverse Cardio-Oncology - Alexandra A.C. Newman Richard Von Itter Kathryn J. Moore Cardiovascular Research Center, Leon H. Charney Division of Cardiology, Department of Medicine, New York University Langone Health (A.A.C.N., R.V.I., K.J.M.). Department of Cell Biology, New York University Grossman School of Medicine (K.J.M.). Circulation
  Circulation, Volume 149, Issue 22, Page 1749-1751, May 28, 2024. (Circulation)
• 08:00
  Double Whammy Complicating Management of Pulmonary Hypertension - Ayesha Salahuddin Ian S. Harris Aarthi Sabanayagam Department of Medicine, Division of Cardiology, University of California San Francisco. Circulation
  Circulation, Volume 149, Issue 22, Page 1770-1774, May 28, 2024. (Circulation)