2 juillet

J Am Soc Nephrol https://jasn.asnjournals.org/

• 07:00
  Nephrology Clinical Trials in Learning Health Systems: The Registry-Based Randomized Clinical Trial - Collins, Michael G.; Hawley, Carmel M.; McDonald, Stephen P. J Am Soc Nephrol
  No abstract available -- Designing Clinical Trials: Clinical Nephrology
• 07:00
  Does Our Classification System for CKD Serve the US Population Well? - Kattah, Andrea G.; Rule, Andrew D. J Am Soc Nephrol
  No abstract available -- Editorial
• 07:00
  Can Kidney Care Be Sustainable? - Piccoli, Giorgina Barbara; Cabiddu, Gianfranca J Am Soc Nephrol
  No abstract available -- Editorial

24 juin

J Am Soc Nephrol https://jasn.asnjournals.org/

• 07:00
  Potassium-Alkali–Enriched Diet, Hypertension, and Proteinuria following Uninephrectomy - Ralph, Donna L.; Ha, Darren; Lei, Hillmin; Priver, Taylor S.; Smith, Scotti D.; McFarlin, Brandon E.; Schwindt, Seth; Pandya, Drishti; Koepsell, Hermann; Pastor-Soler, Nuria M.; Edwards, Aurelie; McDonough, Alicia A. J Am Soc Nephrol
  Background: Losing or donating a kidney is associated with risks of developing hypertension and albuminuria. Few studies address mechanisms or interventions. We investigate potential benefits of a K+- alkali–enriched diet and the mechanisms underlying proteinuria. Methods: Male Sprague Dawley (…) -- Original Article: Acid Base and Electrolyte Disorders
• 07:00
  Angiotensin-II-Type-1a Receptor (AT1aR) and Renal K+ Wasting during Overnight Low-Na+ Intake - Duan, Xin-Peng; Zheng, Jun-Ya; Xiao, Yu; Zhang, Cheng-Biao; Lin, Dao-Hong; Wang, Wen-Hui J Am Soc Nephrol
  Background: Chronic Angiotensin-II (Ang-II) perfusion stimulates Kir4.1/Kir5.1 of the DCT via angiotensin-II-type-1a-receptor (AT1aR) and low-sodium-intake also stimulates Kir4.1/Kir5.1. However, it is not explored the role of AT1aR in mediating the effect of LS on Kir4.1/Kir5.1. Methods: We (…) -- Original Article: Acid Base and Electrolyte Disorders

18 juin

J Am Soc Nephrol https://jasn.asnjournals.org/

• 07:00
  Evolutionary Differences in Uric Acid Metabolism Inform about the Risks of Pig-to-Human Kidney Transplant - Percudani, Riccardo; Capelli, Cristian; Sassi, Giulia; Mori, Giulia J Am Soc Nephrol
  No abstract available -- Perspective
• 07:00
  Association between Acute Declines in Estimated Glomerular Filtration Rate during Renin-Angiotensin System Inhibition and Risk of Adverse Outcomes - Ku, Elaine; Tighiouart, Hocine; McCulloch, Charles E.; Inker, Lesley A.; Adingwupu, Ogechi; Greene, Tom; Estacio, Raymond O.; Woodward, Mark; de Zeeuw, Dick; Lewis, Julia B.; Hannedouche, Thierry; Hou, Fan Fan; Jafar, Tazeen H.; Ima, Enyu; Remuzzi, Guiseppe; Heerspink, Hiddo J.L.; Toto, Robert D.; Sarnak, Mark J. J Am Soc Nephrol
  Background: Declines in glomerular filtration rate (GFR) occur commonly when renin-angiotensin system (RAS) inhibitors are started. Our objective was to determine the relation between declines in estimated GFR during trials of RAS inhibition and kidney outcomes. Methods: We included participants (…) -- Original Article: Chronic Kidney Disease
• 07:00
  Estimated Effect of Restarting Renin-Angiotensin System Inhibitors after Discontinuation on Kidney Outcomes and Mortality - Hattori, Koki; Sakaguchi, Yusuke; Oka, Tatsufumi; Asahina, Yuta; Kawaoka, Takayuki; Doi, Yohei; Hashimoto, Nobuhiro; Kusunoki, Yasuo; Yamamoto, Satoko; Yamato, Masafumi; Yamamoto, Ryohei; Matsui, Isao; Mizui, Masayuki; Kaimori, Jun-Ya; Isaka, Yoshitaka J Am Soc Nephrol
  Background: While renin-angiotensin system inhibitors (RASi) have been the mainstream treatment for patients with CKD, they are often discontinued due to adverse effects such as hyperkalemia and acute kidney injury. It is unknown whether restarting RASi after discontinuation improves clinical (…) -- Original Article: Chronic Kidney Disease

14 juin

J Am Soc Nephrol https://jasn.asnjournals.org/

• 07:00
  Inflammasomes and Acute Kidney Injury - Muruve, Daniel A. J Am Soc Nephrol
  No abstract available -- Editorial

12 juin

J Am Soc Nephrol https://jasn.asnjournals.org/

• 07:00
  The Plasma Metabolome and Risk of Incident Kidney Stones - Ferraro, Pietro Manuel; Li, Yukun; Balasubramanian, Raji; Curhan, Gary C.; Taylor, Eric N. J Am Soc Nephrol
  Background Information on metabolomic profiles in kidney stone formers is limited. To examine independent associations between plasma metabolomic profiles and the risk of incident, symptomatic kidney stones in adults, we conducted prospective nested case-control studies in two large cohorts. (…) -- Original Article: Acid Base and Electrolyte Disorders

10 juin

J Am Soc Nephrol https://jasn.asnjournals.org/

• 07:00
  METTL3-Mediated N6-methyladenosine mRNA Modification and cGAS-STING Pathway Activity in Kidney Fibrosis - Tsai, Yu-Cheng; Hsieh, Tsung-Han; Liao, Yuan-Ru; Tsai, Ming-Tsun; Lin, Tzu-Ping; Lee, Der-Yen; Park, Jihwan; Kim, Donggun; Susztak, Katalin; Yang, Shang-Feng; Lin, Chih-Ching; Li, Szu-Yuan J Am Soc Nephrol
  Background Chemical modifications on RNA profoundly impact RNA function and regulation. m6A, the most abundant RNA modification in eukaryotes, plays a pivotal role in diverse cellular processes and disease mechanisms. However, its importance is understudied in human chronic kidney disease (CKD) (…) -- Original Article: Genetics
• 07:00
  Kidney Volume and Risk of Incident Kidney Outcomes - Wu, Jianhan; Wang, Yifan; Vlasschaert, Caitlyn; Lali, Ricky; Feiner, James; Gaheer, Pukhraj; Yang, Serena; Perrot, Nicolas; Chong, Michael; Paré, Guillaume; Lanktree, Matthew B. J Am Soc Nephrol
  Background: Low total kidney volume (TKV) is a risk factor for chronic kidney disease (CKD). However, evaluations of nonlinear relationships, incident events, causal inference, and prognostic utility beyond traditional biomarkers are lacking. Methods: TKV, height-adjusted TKV, and body surface (…) -- Original Article: Chronic Kidney Disease
• 07:00
  No Time for Cancel Culture: The Importance of Banff Pathology Criteria and Clinical Outcomes - Mengel, Michael; Mannon, Roslyn B. J Am Soc Nephrol
  No abstract available -- Editorial

7 juin

J Am Soc Nephrol https://jasn.asnjournals.org/

• 07:00
  P2Y2R and Cyst Growth in Polycystic Kidney Disease - Kraus, Andre; Skoczynski, Kathrin; Brötsch, Martin; Burzlaff, Nicolai; Leipziger, Jens; Schiffer, Mario; Büttner-Herold, Maike; Buchholz, Bjoern J Am Soc Nephrol
  Key Points Polycystic kidney disease (PKD) is characterized by continuous cyst growth, which results in a decline in kidney function.Deletion of P2Y2R and pharmacological antagonism of purinergic signaling significantly reduced cyst growth in an orthologous PKD mouse model.P2Y2R was expressed in (…) -- Basic Research: Cystic Kidney Disease