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145 articles
25 juin
J Am Med Assoc (JAMA) https://jama.jamanetwork.com/
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This Viewpoint analyzes how the NCCN’s boxed statement that all cancer is best managed in a clinical trial cannot be applied to all patients and calls for its removal from its clinical practice guidelines.
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02:00Study Participants, Future Patients, and Outcomes That Matter in Cancer Clinical Trials J Am Med Assoc (JAMA)Randomized clinical trials (RCTs) define the efficacy of new cancer treatments and drive changes in clinical practice. Although the role of RCTs in generating knowledge is universally accepted, the often-cited benefits of trial participation for individual patients is open for debate. The trial (…)
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02:00Survival Benefit Associated With Participation in Clinical Trials of Anticancer Drugs J Am Med Assoc (JAMA)This systematic review and meta-analysis examines whether patient participation in cancer trials is associated with greater survival benefit compared with routine care.
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To the Editor We think the Phoenix Sepsis Score is an important achievement as a pediatric sepsis definition, which considers the performance and application of the score in lower-resource settings. The score was developed in response to clinician survey results that emphasized that the updated (…)
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02:00Industry Payments to Physicians Endorsing Drugs and Devices on a Social Media Platform J Am Med Assoc (JAMA)This study evaluates adherence to industry and professional standards among physicians endorsing drugs and devices on a social media platform.
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This JAMA Insights discusses the use of monoclonal antibodies or protein-based vaccines to help prevent severe RSV infection in infants, children, and older adults.
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The Review titled “Systemic Lupus Erythematosus: A Review,” published in the May 7, 2024, issue of JAMA, has been updated to provide the absolute mortality rates by sex, age, race, and geographic region in the Prognosis section. This article was corrected online.
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This Medical News article discusses the great resignation in health care and new efforts to create a sustainable medical workforce in the US.
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This Medical News article discusses a randomized clinical trial that investigated the effects of negative emotions on blood vessel dilation.
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The number of mental health and substance use facilities that are owned by private equity firms has steadily increased in the US over the past 10 years, according to findings from about 26 500 facilities nationwide between 2012 and 2023. About 6% of all mental health facilities were private (…)
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More than 40% of women will experience intimate partner violence during their lives, as will more than one-quarter of men. That’s why the US Preventive Services Task Force (USPSTF) recommends screening all women of reproductive age for intimate partner violence, which can include physical, (…)
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Substantial differences existed in the way the 20 leading causes of disease affected females and males worldwide, a study involving data from 1990 to 2021 found.
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Almost all people who inherited 2 identical copies of the APOE4 gene variant had abnormally high levels of amyloid in their cerebrospinal fluid and brain by age 65 years, according to a new study that combined data from more than 3200 brain donors and about 10 000 participants with clinical data.
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The US Food and Drug Administration (FDA) will begin supervising laboratory-developed tests more closely due to concerns that they do not always provide accurate results, the agency recently announced.
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About 7% of people seen in an outpatient setting had at least 1 adverse event, according to findings from about 3100 patients from 11 sites in Massachusetts. The majority of these patients—64%—experienced drug-related adverse events, such as allergic reactions. About 15% of affected patients (…)
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Millions of young people currently use e-cigarettes, according to recent data. However, there are few evidence-backed strategies to help people stop vaping. Now, a double-blind randomized study published in JAMA Internal Medicine suggests that a drug known as cytisinicline might also help curb (…)
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When asked about their feelings on more than 20 topics, older adults listed various health-related costs as their top 6 concerns, based on data from about 3400 respondents to the University of Michigan’s National Poll on Healthy Aging. The majority of respondents aged 50 years or older were (…)
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About 2 years after the global mpox outbreak began, the World Health Organization (WHO) provided updated numbers of mpox cases and revised vaccine recommendations in a new situation report. From 2022 through March 2024, more than 95 200 people have developed mpox infections and 185 patients have (…)
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Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
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This meta-analysis assesses whether Black patients with heart failure and reduced ejection fraction respond differently than patients of other races to renin-angiotensin system (RAS) blockade by examining individual patient data from randomized clinical trials.
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This is the beginning of something for yourself for once, a summer afghan, a simple little throw for meditation,
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Mimesis in poetry is the imitation or re-creation of reality using art. Thinkers ranging from Aristotle to Adorno have wondered at this human capacity to symbolize, and how it helps us make our own sense of, and express to others, both our external and internal worlds. In the poem “Needlework at (…)
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This narrative review summarizes current evidence regarding diagnosis and treatment of chronic pruritus.
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This Viewpoint discusses the recent use of forced nitrogen inhalation as capital punishment in Alabama and describes the body of evidence indicating that forced nitrogen inhalation is an inhumane practice.
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To the Editor We read with great interest the article “International Consensus Criteria for Pediatric Sepsis and Septic Shock” and commend the authors for their dedication to standardizing and improving the care of children with sepsis. By using an empirical approach in a global cohort of (…)
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In Reply Ms Msefula and colleagues raise an important point regarding inclusion of tests and therapies in the Phoenix Sepsis Score that, based on the global survey performed by the Pediatric Sepsis Definition Task Force, may not be universally available. Msefula and colleagues have an associated (…)
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This prospective, multicenter cohort study evaluates the long-term outcomes of men diagnosed with favorable-risk prostate cancer managed with protocol-directed active surveillance, including regular biopsies and prostate-specific antigen screening, from 2008 to 2022.
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This JAMA Patient Page describes age-related macular degeneration development and progression; symptoms and risk factors; and diagnosis, monitoring, and treatment.
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In this narrative medicine essay, a surgical oncologist reflects on his 30-year practice and the care he receives for his leukemia, understanding how vital the relationships and discourse with the care team are for his recovery.
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02:00The Texas Medical Board and the Futility of Medical Exceptions to Abortion Bans J Am Med Assoc (JAMA)This Viewpoint describes the failure of yet another state institution to generate meaningful guidance about medical exceptions to abortion bans.
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This JAMA Guide to Statistics and Methods article discusses accounting for competing risks in clinical research.
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02:00Ransomware Attacks, ED Visits and Inpatient Admissions in Targeted and Nearby Hospitals J Am Med Assoc (JAMA)This case-control study analyzes disruptive ransomware attacks against hospitals in California from 2014 to 2020 and emergency department (ED) and inpatient admissions in attacked and nearby hospitals.
18 juin
J Am Med Assoc (JAMA) https://jama.jamanetwork.com/
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This Viewpoint presents the components of the payment model and the implementation challenges among the Center for Medicare and Medicaid Innovation, state Medicaid agencies, patients, and manufacturers.
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High drug prices in the US are a serious problem for both patients and the health care system. Prices of branded drugs are driven higher by monopoly dynamics: patents and other exclusive marketing rights allow companies to increase prices and restrict supply. Firms earn extraordinary profits (…)
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This randomized clinical trial assesses the effect of krill oil supplementation vs placebo on knee pain improvement in patients with knee osteoarthritis, significant knee pain, and effusion-synovitis.
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These are not the final few months of my life, not the last bowl of salad I add a few spoons of tuna and mayo to. I’m not going to die on a date printed in the calendar that hangs on my fridge with cheesy pictures of Yosemite and captions like Bike to Work Day. I can sit here at the kitchen (…)
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In Reply We thank Drs Sedghi and Siepmann for their comments. Indeed, all trials included in our individual participant meta-analysis enrolled only patients directly presenting at thrombectomy-capable stroke centers. Hence, the data presented in our study are applicable only to this exact (…)
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This JAMA Insights provides recommendations for Chagas disease screening, diagnosis, and management in the US
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02:00Dispensing of Glucagon-Like Peptide-1 Receptor Agonists to Adolescents and Young Adults, 2020-2023 J Am Med Assoc (JAMA)This study uses data from US retail pharmacies to assess national GLP-1RA dispensing to adolescents and young adults from 2020-2023.
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To the Editor A recent individual patient data meta-analysis of 6 randomized trials found that the beneficial effect of intravenous thrombolysis (IVT) before thrombectomy in patients with anterior-circulation large-vessel occlusion diminished with time from onset of stroke symptoms to (…)
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This JAMA Patient Page discusses social isolation and loneliness as important public health concerns, especially among older adults.
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In this narrative medicine essay, a newly minted pediatric critical care physician learns firsthand what holistic medical care is from the love and attention she received during a hospitalization for mediastinal lymphoma.
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This Viewpoint discusses dismantling language barriers via multipronged approaches grounded in innovation, human-centered design, and systems thinking in 3 key areas.
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To the Editor We read Dr Sanchez-Pinto and colleagues’ study with interest, but we are concerned that the final Phoenix 4-organ model does not include acute kidney injury (AKI) assessment. Additionally, the Phoenix 8-organ model used only a single serum creatinine threshold. Despite inclusion of (…)
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In Reply We are grateful to Dr Thadani and colleagues for their interest in our work and applaud their efforts to improve outcomes from AKI around the world. We agree that AKI is important to assess and treat in children with sepsis in any environment and that children in some less-resourced (…)
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02:00Shingles Vaccination in Medicare Part D After Inflation Reduction Act Elimination of Cost Sharing J Am Med Assoc (JAMA)This cross-sectional study uses data from retail pharmacies to examine shingles vaccine uptake among Medicare Part D beneficiaries following an IRA policy to eliminate cost sharing.
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This Medical News article is an interview with Saurabh Jha, a cardiothoracic radiologist and an associate professor of radiology at the University of Pennsylvania, and JAMA Editor in Chief Kirsten Bibbins-Domingo.
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US public health preparedness and response to highly pathogenic avian influenza A(H5N1) viruses are assessed in this survey study conducted by the CDC.
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Without a dissenting vote, the House of Delegates of the American Medical Association adopted last week a resolution calling on the Board of Trustees to use its best endeavors to have repealed such sections of the national prohibition acts as may interfere with the proper relation between the (…)
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Current strategies to protect children from malaria—administration of new RTS,S/AS01 or R21/Matrix-M vaccines as well as seasonal medications—require about 20 health care visits by the time a child reaches age 5 years. However, an approach involving the annual administration of a monoclonal (…)
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The proportion of people who die while pregnant or within 42 days after their pregnancy ends has been steadily increasing in the US. Now, updated numbers from the National Vital Statistics System indicate promising trends in maternal mortality rates. About 22 people per 100 000 live births died (…)
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Intradermal injections that were one-fifth of the standard mpox vaccine dose generated antibody responses equivalent to those of subcutaneous injections of the standard dose at 6 weeks, based on results from 225 US adults aged 18 to 50 years. No participants experienced serious adverse events (…)
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The US Food and Drug Administration recently approved pivmecillinam, sold as Pivya, for uncomplicated urinary tract infections (UTIs) in females aged 18 years or older with no structural abnormalities of their urinary tract. UTIs affect about 50% of females at some point during their life, the (…)
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Although heart failure mortality rates fell between 1999 and 2012, the proportion of people dying from the condition in the US has increased in recent years, according to a study published in JAMA Cardiology. By 2021, the heart failure mortality rate was higher than in 1999, signaling that (…)
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Up to 45% of physicians are subject to noncompete clauses, contractual requirements that can prevent them from changing jobs, which can limit competition and access to care, according to the American Medical Association. However, employers will no longer be allowed to enforce noncompete clauses (…)
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Long-term Veterans Health Administration (VA) nursing home residents who started new medications to treat high blood pressure were more than twice as likely to experience a fracture than those who did not, according to a cohort study involving more than 29 600 VA participants, almost all male, (…)
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The US Food and Drug Administration (FDA) granted emergency use authorization to pemivibart, marketed as Pemgarda, to protect people who are immunocompromised from COVID-19. Pemivibart is the only long-acting monoclonal antibody available in the US for preexposure prophylaxis after the FDA (…)
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People who received a microneedle patch that delivered a measles and rubella vaccine mounted immune responses that were equivalent to those vaccinated via subcutaneous injection, according to data from a randomized clinical trial involving 285 participants from The Gambia, including 240 toddlers (…)
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In Reply We appreciate the Letter by Drs Stern and Hafferty about our recent Viewpoint, which gave priority to highlighting the large and growing body of evidence that patients of physicians who demonstrate more medical knowledge have better prognoses on a host of important outcomes. In doing (…)
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This Special Communication examines the Federal Trade Commission’s policy and legal actions related to alleged misconduct, consolidation, and anticompetitive behavior in the pharmaceutical market between 2000 and 2022.
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A 36-year-old man with obesity and dyslipidemia presented with elevated liver enzymes following a liver transplant to treat acute-on-chronic liver failure due to alcohol-associated hepatitis. What would you do next?
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This Viewpoint discusses how data gaps in published research impede clinicians’ ability to clearly discuss the risks and benefits of amyloid-lowering drugs for treating Alzheimer disease.
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02:00Harnessing the Electronic Health Record to Improve Empiric Antibiotic Prescribing J Am Med Assoc (JAMA)Approximately half of hospitalized adults in the US receive antibiotics, with pneumonia and urinary tract infection (UTI) being the 2 most frequent indications. Estimates suggest about 30% of all antibiotics prescribed in US hospitals are either unnecessary or suboptimal, and extended-spectrum (…)
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This clinical trial examines the effect of an antibiotic stewardship bundle (education, feedback, and real-time multidrug-resistant organism risk-based CPOE prompts) vs routine stewardship on antibiotic selection during the first 3 hospital days in adults with pneumonia.
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02:00Stewardship Prompts to Improve Antibiotic Selection for Urinary Tract Infection J Am Med Assoc (JAMA)This clinical trial evaluates whether computerized provider order entry prompts providing patient- and pathogen-specific multidrug-resistant organism risk estimates could reduce use of empiric extended-spectrum antibiotics for treatment of urinary tract infections.
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Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
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To The Editor The American Board of Internal Medicine (ABIM) has an outsized influence as the arbiter of internal medicine physician quality, given the alternatives of minimal state regulations, spotty insurance-based estimates, and random patient-based ratings. A recent Viewpoint responded to (…)
11 juin
J Am Med Assoc (JAMA) https://jama.jamanetwork.com/
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In its revised Recommendation Statement, the US Preventive Services Task Force (USPSTF) now recommends that all women undergo routine breast cancer screening every other year beginning at age 40 years. This is an adjustment from the 2016 recommendation for all women to start at age 50 and for (…)
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02:00USPSTF Report: Collaborative Modeling to Compare Breast Cancer Screening Strategies J Am Med Assoc (JAMA)This modeling study uses Cancer Intervention and Surveillance Modeling Network models and national data on breast cancer incidence, mammography performance, treatment effects, and other-cause mortality in US women without previous cancer diagnoses to estimate outcomes of various mammography (…)
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To the Editor A recent clinical trial demonstrated that apixaban did not significantly reduce recurrent stroke risk compared with aspirin in patients with cryptogenic stroke and evidence of atrial cardiopathy without atrial fibrillation. However, we had some concerns about this study. First, it (…)
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To the Editor The recent Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke (ARCADIA) trial did not demonstrate superiority of apixaban over aspirin for secondary prevention in patients with cryptogenic stroke and atrial cardiopathy. In this study, atrial (…)
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In Reply In response to our recent article, Dr Chi and colleagues raise an important point regarding uncertainty about optimal biomarkers of atrial cardiopathy. Compared with ARCADIA patients who qualified for enrollment in our study only by the NT-proBNP criterion, those who qualified by only (…)
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Health care is becoming more and more distanced. Clinicians must overcome not just mountains of data, burdensome electronic health records, and ever-increasing numbers of machines that separate us from patients, but more recently also navigate telemedicine and AI-driven chatbots. (…)
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Cardiovascular risk assessment has become an essential part of preventive strategies designed to target risk factor interventions and has contributed to dramatic reductions in cardiovascular disease mortality during the past 60 years in the US and other countries. Beginning in the 1960s, (…)
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About 10% of people with multiple sclerosis (MS) had an autoantibody signature that was present at least 5 years before symptoms, according to an analysis of blood samples from 500 military service members. Researchers collected the first sample an average of 5 years before some participants (…)
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Hospitalized patients in the US tended to have a lower chance of dying or being readmitted within 30 days when they were treated by female physicians rather than male clinicians, a recent study published in Annals of Internal Medicine found. The difference in outcomes for patients examined by (…)
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The average physician is unlikely to build a computer in his basement from a kit. But the principles of computer analysis are not difficult to master. Evidence of the growing importance of these complex electronic machines is found in the announcement that the potential of the computer in (…)
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To the Editor In their recent Viewpoint, Dr Goodman and colleagues examined artificial intelligence (AI)–generated clinical summaries and identified concerns regarding variability, bias, and single-word errors in their AI summaries generated through the ChatGPT model. However, it must be noted (…)
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In Reply We thank Ms Chen and Dr Thornton for their interest in our Viewpoint examining potential benefits and challenges of AI-generated clinical summaries. We fully agree that future studies should evaluate how AI summaries influence physician decision-making and clinical outcomes. We (…)
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Prior research has suggested that antipsychotic drugs might be overprescribed for people with dementia, despite known risks of stroke and sudden cardiac death. Now, findings from a new study in The BMJ indicate that the range of serious adverse outcomes associated with antipsychotics in these (…)
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A multiyear global collaboration among public health agencies has led to new terminology for pathogens such as SARS-CoV-2 that can spread through the air, the World Health Organization (WHO) announced. The report by the WHO and partners, including the US Centers for Disease Control and (…)
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Pregnant people who experienced adverse pregnancy outcomes had up to a 50% increased risk of dying from any cause up to 46 years after giving birth, according to data from a cohort study involving about 2.2 million participants from Sweden who gave birth between 1973 and 2015. Cardiovascular and (…)
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The US Department of Health and Human Services (HHS) recently announced a final rule that increases privacy protections for people seeking legal reproductive care, such as an abortion, either in their home state or by traveling to another one. The modification to the Health Insurance Portability (…)
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Some policymakers have suggested increasing the eligibility age for Medicare and implementing work requirements for Medicaid coverage to reduce US health care costs. However, a recent analysis involving data projections from the Census Bureau suggests that the proposed changes would cost (…)
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The US Centers for Medicare & Medicaid Services (CMS) recently finalized a rule establishing the first minimum staffing requirements for nursing homes after an earlier version was proposed last September. The new rule will “hold nursing homes accountable for providing safe and (…)
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02:00Late-Stage Cancer End Points to Speed Cancer Screening Clinical Trials—Not So Fast J Am Med Assoc (JAMA)In this issue of JAMA, Feng et al studied whether late-stage cancer (ie, stage III or stage IV cancer), rather than cancer-specific mortality, was an acceptable alternative end point in clinical trials of cancer screening. The authors analyzed 41 clinical trials conducted in Europe, North (…)
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This 2024 Recommendation Statement from the US Preventive Services Task Force recommends biennial screening mammography for women aged 40 to 74 years (B recommendation) and concludes that evidence is insufficient to assess the balance of benefits and harms of screening mammography in women 75 (…)
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In this JAMA Patient Page, the US Preventive Services Task Force provides a guide to screening for breast cancer.
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This systematic review to support a 2024 US Preventive Services Task Force Recommendation Statement summarizes published evidence on the benefits and harms of screening for breast cancer in adult females.
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This Viewpoint discusses laws mandating insurance coverage of biomarker testing to broaden access to care for patients with cancer.
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This Medical News story discusses new USPSTF recommendations about the timing of screening mammograms.
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This study evaluates the prognostic value of routinely available cardiovascular biomarkers when added to established risk factors in the identification of individuals at high risk for atherosclerotic cardiovascular disease.
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To the Editor We have several concerns about the recent trial that examined apixaban for prevention of recurrence after cryptogenic stroke in patients with atrial cardiopathy.
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02:00Mortality in Patients Hospitalized for COVID-19 vs Influenza in Fall-Winter 2023-2024 J Am Med Assoc (JAMA)This cohort study evaluates the risk of death in patients hospitalized for COVID-19 or seasonal influenza following the emergence of the JN.1 variant in winter 2023.
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Since her birth with half a brain The doctors have been kind, So awed by her determination they loan a private Room for the transient child to be and Show the worth of being Even if
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This Viewpoint discusses the ongoing lawsuit between plaintiffs who had been affected by atypical femoral fractures while receiving alendronate and the drug manufacturer.
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02:00Cancer Stage Compared With Mortality as End Points in Randomized Clinical Trials of Cancer Screening J Am Med Assoc (JAMA)This meta-analysis of 41 randomized clinical trials of cancer screening compares cancer-specific mortality with stage III-IV cancer as end points.
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In this narrative medicine essay, a second-year pediatric resident bears the scars from the terror that descended the moment of her son’s birth at 31 weeks’ gestation, terror relived even after he has come home healthy.
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This Medical News story discusses the development of experimental combination vaccines for adults.
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This JAMA Insights in the Communicating Medicine series explores the concept of “prebunking,” a psychological inoculation technique that could help prevent the spread of misinformation.
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Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
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A urine-based test involving 18 genes was more accurate at diagnosing high-grade prostate cancer than existing biomarker tests such as blood levels of prostate-specific antigen (PSA), according to a recent study published in JAMA Oncology.
4 juin
J Am Med Assoc (JAMA) https://jama.jamanetwork.com/
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This study of individual participant data from 6 pooled cohorts assesses whether resolution of elevated childhood non–high-density lipoprotein cholesterol (non–HDL-C) by adulthood is associated with reduced risk of clinical cardiovascular disease (CVD) events.
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02:00Assessing the Real-World Effectiveness of Immunizations for Respiratory Syncytial Virus J Am Med Assoc (JAMA)This Viewpoint discusses recommendations from the US Centers for Disease Control and Prevention for newly licensed immunizations for respiratory syncytial virus in infants, children with high-risk conditions, and older adults.
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In Reply We appreciate letters about our Review on thyroid cancer. In response to the comments by Drs Beheshtirouy and Shayanfar, the causal association between GLP-1 RA use and thyroid cancer is complex and requires careful consideration of factors that directly or indirectly influence (...)
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To the Editor A recent Review discussed the complexity of thyroid cancer. First, we would like to highlight the importance of distinguishing between benign and malignant thyroid nodules preoperatively.
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To the Editor A recent Review discussed exposure to ionizing radiation as a common risk factor for thyroid cancer. However, it is important to consider additional risk factors for thyroid cancer.
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02:00Substances in Counterfeit Prescription Pills Seized by Law Enforcement, 2017-2022 J Am Med Assoc (JAMA)This study examines substances identified during testing of counterfeit prescription pills seized by law enforcement in Rhode Island from 2017 to 2022.
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Again left fingers enter the chest
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This Viewpoint discusses the importance of researcher access to federal health care data following a CMS decision to limit the use of physical data and proposes solutions to maintain access and security.
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This JAMA Arts and Medicine feature describes ways in which Fritz Kahn shared a prescient and nuanced vision of technology’s role in the patient-physician interaction, a topic of continued interest and relevance today, through his illustrations.
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In Reply We thank Drs Schoenmakers and Fraser for their comments on our study. We reported the US experience with denosumab administration among dialysis-dependent patients, finding the weighted cumulative incidence of severe hypocalcemia (ie, <7.5 mg/dL or emergent care) at 12 weeks to (...)
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This cross-sectional study assesses the prevalence and temporal evolution of cardiovascular-kidney-metabolic syndrome stages.
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To the Editor We have some concerns about the recent retrospective public health surveillance study of older female dialysis-dependent patients who were treated with denosumab for osteoporosis.
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In this narrative medicine essay, a lecturer in narrative medicine strives to accept her best self by surmounting the barriers of itchy skin and unsightly red patches caused by chronic atopic dermatitis.
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A 3-year-old had spontaneous gingival hemorrhage and bilateral limb weakness with inability to bear weight. He had no preceding oral trauma or recent infection, took no regular medications, and had no recent use of aspirin or nonsteroidal anti-inflammatory drugs; his diet was limited to (...)
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This randomized trial assesses the effect of ponatinib vs imatinib combined with low-intensity chemotherapy on disease remission in adults with newly diagnosed Philadelphia chromosome–positive acute lymphoblastic leukemia (ALL).
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The refreshing influence of the weekly recurring “day of rest” on a person subjected to the strenuous routine of a busy life is a feature which he himself can duly appreciate in terms of his “feelings” and “spirits.” If it is desired to demonstrate the need of such relaxation and the benefits (...)
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In this issue of JAMA, Jabbour and colleagues report results from the interim analysis of the PhALLCON randomized trial with ponatinib vs imatinib, combined with reduced-intensity chemotherapy. They found ponatinib to have superior efficacy and a comparable safety profile for frontline (...)
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This JAMA Insights article reviews Americans with Disabilities Act (ADA) rules for patients, visitors, and other members of the public bringing service animals into health care settings.
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This Medical News article discusses the current H5N1 avian influenza outbreak in US dairy cattle and its implications for occupational and public health.
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This JAMA Patient Page describes allergic skin reactions from contact with poison ivy, poison oak, and poison sumac plants, and how to treat rashes caused by these plants.
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02:00Causal Inference and Effects of Interventions From Observational Studies in Medical Journals J Am Med Assoc (JAMA)This Special Communication examines drawing causal inferences about the effects of interventions from observational studies in medical journals.
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This Medical News story discusses an analysis of deaths by suicide among NCAA athletes over the past 20 years.
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The Special Communication “Causal Inferences About the Effects of Interventions From Observational Studies in Medical Journals,” published in this issue of JAMA, provides a rationale and framework for considering causal inference from observational studies published by medical journals. Our (...)
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Currently, there are few reliable tools for diagnosing mild traumatic brain injuries or predicting their likely course, which can include poor neuropsychiatric outcomes. But results published in JAMA Network Open show that an advanced form of magnetic resonance imaging picked up changes in the (...)
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02:00Exercise Might Lower Heart Disease Risk in Part By Decreasing Stress in the Brain J Am Med Assoc (JAMA)Physical activity might reduce the risk of cardiovascular disease partly by decreasing activity in parts of the brain related to stress, a study in the Journal of the American College of Cardiology suggests. Researchers looked at data from more than 50 300 adults in Massachusetts who completed (...)
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Patients who were affected by diagnostic errors were more likely to have stigmatizing language in their medical records, according to a new analysis in JAMA Internal Medicine. The cohort study involved more than 2300 hospital admissions during which patients died or were transferred to the (...)
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The number of young people who sought permanent contraception—such as tubal ligations or vasectomies—rose immediately after the US Supreme Court’s decision in Dobbs v Jackson Women’s Health Organization, researchers reported in JAMA Health Forum. The data came from US patients aged 18 to 30 years.
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Previous studies have suggested that many people who use proton pump inhibitors (PPIs) might not have a clinical indication for doing so, which is concerning because PPIs have been associated with chronic kidney disease and infection in some observational studies. Now, recent results published (...)
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Nigeria will be the first country in the world to vaccinate residents aged 1 through 29 years with Men5CV, a novel 1-dose vaccine that protects people from 5 major strains of the meningococcus bacteria (Neisseria meningitidis), the World Health Organization (WHO) announced. The news comes amid (...)
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The majority of people who are currently unhoused—67%—have mental health disorders, according to a systematic review and meta-analysis of 85 studies mainly from Canada, Germany, and the US involving more than 48 400 participants. The lifetime prevalence of mental health disorders among people (...)
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About 42% of patients with infections caused by pathogens that were resistant to all first-line antibiotics received only older antibiotics rather than newer ones more recently approved by the US Food and Drug Administration, a new study found. The results were based on data from 619 US (...)
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The COVID-19 vaccines made by Pfizer-BioNTech and Moderna do not cause such conditions as female infertility, myocardial infarction, Bell palsy, or Guillain-Barré syndrome in adults, according to a report by the National Academies of Sciences, Engineering, and Medicine that reviewed evidence (...)
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An antecedent body of work established nearly 20 years ago benchmarked the nuanced distinctions of heart failure affecting African American people. Summative statements established a nearly 2-fold higher incidence, earlier onset, greater severity at the time of diagnosis, a more likely (...)
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This study used data on Black participants in 4 large observational studies to better define the natural history of disease in V142I variant carriers across mid to late life, assess variant modifiers, and estimate cardiovascular burden to the US population.
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02:00Addressing Health Disparities—The Case for Variant Transthyretin Cardiac Amyloidosis Grows Stronger J Am Med Assoc (JAMA)There has been a transformational change in understanding heart failure due to transthyretin cardiac amyloidosis (ATTR-CA). Previously considered a rare condition, the widespread adaptation of nuclear imaging to establish the diagnosis has led to the recognition that ATTR-CA is commonly (...)
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02:00Error in the Exclusion of Participants From Analysis in the ACTIV-6 Platform Randomized Clinical Trial J Am Med Assoc (JAMA)To the Editor On behalf of my coauthors, I write to explain errors that we identified in the Original Investigation “Effect of Higher-Dose Ivermectin for 6 Days vs Placebo on Time to Sustained Recovery in Outpatients With COVID-19: A Randomized Clinical Trial,” published online on February 20, (...)
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The Original Investigation titled “Effect of Higher-Dose Ivermectin for 6 Days vs Placebo on Time to Sustained Recovery in Outpatients With COVID-19: A Randomized Clinical Trial,” published in the March 21, 2023, issue of JAMA, was corrected to fix an error in which 226 participants were (...)
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Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
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