2 juillet

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 02:00
  An Adaptive Behavioral Intervention for Weight Loss Management J Am Med Assoc (JAMA)
  This noninferiority randomized trial compares the effects of a wireless system designed to provide daily feedback on progress in lifestyle change and weight loss vs the same system with additional human coaching on weight change among people with overweight and obesity.
• 02:00
  Text Messages With Financial Incentives for Men With Obesity J Am Med Assoc (JAMA)
  This randomized clinical trial assesses whether text messaging combined with financial incentives or text messages alone could help men with obesity lose weight at 12 months.
• 02:00
  Medical Management vs Bariatric Surgery in Type 2 Diabetes—Reply J Am Med Assoc (JAMA)
  In Reply We agree with Dr Fujieda that weight during childhood and adolescence is an important phenotypic variable, given that birth weight and early-life weight trajectories are associated with risk of obesity, type 2 diabetes, and cardiovascular outcomes. Unfortunately, the ARMMS-T2D (…)
• 02:00
  Is Weight Loss–Induced Muscle Mass Loss Clinically Relevant? J Am Med Assoc (JAMA)
  This Viewpoint explores the effects of weight loss achieved through GLP-1–based antiobesity medications on weight regain, fat-free mass, and skeletal muscle mass in people with obesity.
• 02:00
  Sex Differences in Primary Care–Based Chronic Kidney Disease Management J Am Med Assoc (JAMA)
  This retrospective study uses electronic health record data to investigate the sex differences in guideline-based management outcomes between male and female patients with chronic kidney disease.
• 02:00
  Lifestyle Interventions for Obesity in the Era of GLP-1 Receptor Agonists J Am Med Assoc (JAMA)
  A central goal of obesity treatment is sustaining weight loss of at least 5%, with at least 10% weight loss conferring greater cardiometabolic health benefits. As new pharmacological antiobesity therapies emerge, including incretin-based treatments that produce a mean of 15% to 21% weight loss, (…)
• 02:00
  Sick Day Abecedarian J Am Med Assoc (JAMA)
  A thin spun sugar drips gossamer cobwebs. Bakers drip these strands from rolling pins and circle them into amber sugar nests to decorate an elaborate cake laden with fruit. Egg custards wobble in their shallow tins. Fevers in the tent and on the couch as we watch The Great British Baking Show (…)
• 02:00
  Failure to Rescue as a Quality Measure in Sepsis J Am Med Assoc (JAMA)
  This Viewpoint discusses the limitations of current tools to improve sepsis outcomes and proposes that these tools be supplemented with “failure to rescue,” a systems-level approach for recognizing and addressing complications and managing sepsis throughout the hospitalization period.
• 02:00
  Medical Management vs Bariatric Surgery in Type 2 Diabetes J Am Med Assoc (JAMA)
  To the Editor In their pooled analysis of 4 randomized trials, Dr Courcoulas and colleagues concluded that individuals who underwent bariatric surgery had improved diabetes outcomes compared with those who received medical/lifestyle interventions. I would like to address a specific point that we (…)
• 02:00
  US Journals’ Responsibility to Report on Public Health Crisis in Gaza J Am Med Assoc (JAMA)
  In this Viewpoint, the authors write that US-based medical journals have an obligation to create space for discourse about the human costs of war and other political drivers of health.
• 02:00
  Editorials J Am Med Assoc (JAMA)
• 02:00
  Formulary Coverage of Brand-Name Adalimumab and Biosimilars J Am Med Assoc (JAMA)
  This study examines formulary coverage of brand-name adalimumab and biosimilars across Medicare Part D plans.
• 02:00
  Patient Information: Prevention of Falls in Older Adults J Am Med Assoc (JAMA)
  This JAMA Patient Page describes risk of falls in older adults and fall prevention recommendations from the US Preventive Services Task Force.
• 02:00
  USPSTF Review: Interventions to Prevent Falls in Older Adults J Am Med Assoc (JAMA)
  This systematic review to support a 2024 US Preventive Services Task Force Recommendation Statement summarizes published evidence on the benefits and harms of primary care–relevant multifactorial and exercise interventions to prevent falls among community-dwelling adults 65 years or older.
• 02:00
  USPSTF Recommendation: Interventions to Prevent Falls in Community-Dwelling Older Adults J Am Med Assoc (JAMA)
  This 2024 Recommendation Statement from the US Preventive Services Task Force recommends exercise interventions to prevent falls in community-dwelling adults 65 years or older who are at increased risk for falls (B recommendation) and that clinicians individualize the decision to offer (…)
• 02:00
  Poll: Roughly 12% of US Adults Have Used a GLP-1 Drug, Even If Unaffordable J Am Med Assoc (JAMA)
  About 1 in 8 US adults aged 18 years or older report having ever used a glucagon-like peptide 1 (GLP-1) agonist medication, according to results from a KFF (formerly Kaiser Family Foundation) poll involving about 1500 respondents. This includes the 6% of people currently using a GLP-1 agonist (…)
• 02:00
  Meta-Analysis: Low Testosterone in Men Tied to Increased Risk of Death J Am Med Assoc (JAMA)
  Men with endogenous testosterone levels lower than 213 ng/dL tended to have a higher risk of dying from any cause, according to an analysis of data from 11 studies involving more than 24 100 participants. Although testosterone levels vary by age, the cut-off for low testosterone concentrations (…)
• 02:00
  Preventing Falls in Older Persons J Am Med Assoc (JAMA)
  Among older persons, falls are common (about 25% of older US adults fall each year), injurious (approximately 37% of those who fall require medical treatment or restrict their activity for at least 1 day), expensive (approximately $50 billion per year is spent on medical costs related to falls), (…)
• 02:00
  Ultraprocessed Food Associated With Small Increase in Mortality J Am Med Assoc (JAMA)
  Previous research has linked consumption of ultraprocessed foods with many health concerns, including type 2 diabetes, cardiovascular disease, and mental health disorders. Now, a new cohort study published in The BMJ suggests that people who tended to eat a large daily amount of ultraprocessed (…)
• 02:00
  WHO Releases Guidance to Reduce Catheter-Associated Infections J Am Med Assoc (JAMA)
  Amid rising antimicrobial resistance that poses a “global threat,” the World Health Organization (WHO) recently announced recommendations aimed at reducing the number of people who are affected by sepsis and other serious infections caused by catheters placed in blood vessels. Up to 70% of (…)
• 02:00
  Adding Salt to Food at Mealtime Associated With Stomach Cancer Risk J Am Med Assoc (JAMA)
  People in the UK who reported always adding salt to their food while sitting at the table had a 41% higher risk of being diagnosed with gastric cancer compared with those who never or rarely added salt, a recent study published in Gastric Cancer found. But although adding salt to one’s food was (…)
• 02:00
  Receiving Abortion Medication Through Mail Was Safe, Effective J Am Med Assoc (JAMA)
  About 98% of people who received mifepristone and misoprostol through a mail-order pharmacy experienced complete abortions, according to new data reported in JAMA Internal Medicine. Only 0.6% experienced serious adverse events that resulted in hospitalization, which is similar to the (…)
• 02:00
  Self-Monitoring and Managing Medications Improved High Blood Pressure J Am Med Assoc (JAMA)
  People who monitored their blood pressure at home and modified their medications based on the readings lowered their blood pressure more than those in a control group who received routine blood pressure management from a physician, according to results from a randomized clinical trial involving (…)
• 02:00
  CDC: Deaths From Drowning Climb in the US J Am Med Assoc (JAMA)
  More than 4500 people died from drowning each year between 2020 and 2022, an increase over the roughly 4100 lives lost in 2019, according to results from a US Centers for Disease Control and Prevention (CDC) report. Pandemic-related disruptions could have played a role in the uptick, the (…)
• 02:00
  Flavored Vapes Might Expose Users to Hundreds of Dangerous Byproducts J Am Med Assoc (JAMA)
  The liquid in flavored e-cigarettes likely produces an array of harmful chemicals when heated, as occurs during vaping, a recent study in Scientific Reports found. The researchers used artificial intelligence to predict what would happen when 180 substances known to be present in flavored (…)
• 02:00
  JAMA J Am Med Assoc (JAMA)
• 02:00
  How Common Is Long COVID? J Am Med Assoc (JAMA)
  This Medical News article discusses new US household survey data that found differences in long COVID rates based on preexisting chronic conditions and other factors.
• 02:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 02:00
  ADHD Pharmacotherapy and Mortality J Am Med Assoc (JAMA)
  To the Editor Dr Li and colleagues report that among individuals diagnosed with attention-deficit/hyperactivity disorder (ADHD), medications to treat ADHD might reduce the 2-year mortality rate. This study has several features warranting further explanation.
• 02:00
  ADHD Pharmacotherapy and Mortality—Reply J Am Med Assoc (JAMA)
  In Reply We appreciate the comments from Mr Richards-Belle and colleagues and Dr Zarkowski regarding our recently published study. Their comments highlight important considerations in pharmacoepidemiological studies using real-world data.
• 02:00
  Home Blood Pressure Telemonitoring and Nurse Case Management for Black and Hispanic Patients With Stroke J Am Med Assoc (JAMA)
  This clinical trial compares the effectiveness of nurse case management plus home blood pressure telemonitoring (HBPTM) vs HBPTM alone in achieving greater systolic blood pressure reduction at 12 months and lower rate of stroke recurrence at 24 months among Black and Hispanic stroke survivors (…)
• 02:00
  Coming Home J Am Med Assoc (JAMA)
  In this narrative medicine essay, a pediatrician channels James Herriott as she attempts to save a hatchling in the basement with nonsterile equipment while her young daughters look on.
• 02:00
  Health Care for People Experiencing Homelessness J Am Med Assoc (JAMA)
  This JAMA Insights examines the adverse effects of homelessness on physical and mental health and suggests strategies to improve access to health care, services, and housing for people experiencing homelessness.
• 02:00
  ADHD Pharmacotherapy and Mortality J Am Med Assoc (JAMA)
  To the Editor Drs Li and colleagues adopted a method for assessing causality from observational data, a target trial emulation, to compare mortality among individuals with ADHD who received ADHD medication with those who did not. Similar to randomized clinical trials that the method is designed (…)

25 juin

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 02:00
  Are Patients With Cancer Best Managed in a Clinical Trial J Am Med Assoc (JAMA)
  This Viewpoint analyzes how the NCCN’s boxed statement that all cancer is best managed in a clinical trial cannot be applied to all patients and calls for its removal from its clinical practice guidelines.
• 02:00
  Study Participants, Future Patients, and Outcomes That Matter in Cancer Clinical Trials J Am Med Assoc (JAMA)
  Randomized clinical trials (RCTs) define the efficacy of new cancer treatments and drive changes in clinical practice. Although the role of RCTs in generating knowledge is universally accepted, the often-cited benefits of trial participation for individual patients is open for debate. The trial (…)
• 02:00
  Survival Benefit Associated With Participation in Clinical Trials of Anticancer Drugs J Am Med Assoc (JAMA)
  This systematic review and meta-analysis examines whether patient participation in cancer trials is associated with greater survival benefit compared with routine care.
• 02:00
  Pediatric Phoenix Sepsis Score Challenges J Am Med Assoc (JAMA)
  To the Editor We think the Phoenix Sepsis Score is an important achievement as a pediatric sepsis definition, which considers the performance and application of the score in lower-resource settings. The score was developed in response to clinician survey results that emphasized that the updated (…)
• 02:00
  Current Comment J Am Med Assoc (JAMA)
• 02:00
  Industry Payments to Physicians Endorsing Drugs and Devices on a Social Media Platform J Am Med Assoc (JAMA)
  This study evaluates adherence to industry and professional standards among physicians endorsing drugs and devices on a social media platform.
• 02:00
  Therapies to Decrease Severe Respiratory Syncytial Virus Illness J Am Med Assoc (JAMA)
  This JAMA Insights discusses the use of monoclonal antibodies or protein-based vaccines to help prevent severe RSV infection in infants, children, and older adults.
• 02:00
  Updated Absolute Mortality Rates of Lupus J Am Med Assoc (JAMA)
  The Review titled “Systemic Lupus Erythematosus: A Review,” published in the May 7, 2024, issue of JAMA, has been updated to provide the absolute mortality rates by sex, age, race, and geographic region in the Prognosis section. This article was corrected online.
• 02:00
  To Fix Burnout, New Initiatives Go Beyond Worker Resilience J Am Med Assoc (JAMA)
  This Medical News article discusses the great resignation in health care and new efforts to create a sustainable medical workforce in the US.
• 02:00
  What Anger Does to the Blood Vessels J Am Med Assoc (JAMA)
  This Medical News article discusses a randomized clinical trial that investigated the effects of negative emotions on blood vessel dilation.
• 02:00
  Private Equity Owns 25% of Mental Health Facilities in Some States J Am Med Assoc (JAMA)
  The number of mental health and substance use facilities that are owned by private equity firms has steadily increased in the US over the past 10 years, according to findings from about 26 500 facilities nationwide between 2012 and 2023. About 6% of all mental health facilities were private (…)
• 02:00
  Too Few Clinicians Screen Patients for Intimate Partner Violence J Am Med Assoc (JAMA)
  More than 40% of women will experience intimate partner violence during their lives, as will more than one-quarter of men. That’s why the US Preventive Services Task Force (USPSTF) recommends screening all women of reproductive age for intimate partner violence, which can include physical, (…)
• 02:00
  Stark Differences Exist in Health, Disability Between Males and Females J Am Med Assoc (JAMA)
  Substantial differences existed in the way the 20 leading causes of disease affected females and males worldwide, a study involving data from 1990 to 2021 found.
• 02:00
  Study: 2 APOE4 Copies May Indicate Genetic Form of Alzheimer Disease J Am Med Assoc (JAMA)
  Almost all people who inherited 2 identical copies of the APOE4 gene variant had abnormally high levels of amyloid in their cerebrospinal fluid and brain by age 65 years, according to a new study that combined data from more than 3200 brain donors and about 10 000 participants with clinical data.
• 02:00
  FDA Announces Increased Oversight of Some Diagnostic Laboratory Tests J Am Med Assoc (JAMA)
  The US Food and Drug Administration (FDA) will begin supervising laboratory-developed tests more closely due to concerns that they do not always provide accurate results, the agency recently announced.
• 02:00
  Outpatient Adverse Events More Common, Preventable Than Expected J Am Med Assoc (JAMA)
  About 7% of people seen in an outpatient setting had at least 1 adverse event, according to findings from about 3100 patients from 11 sites in Massachusetts. The majority of these patients—64%—experienced drug-related adverse events, such as allergic reactions. About 15% of affected patients (…)
• 02:00
  Cytisinicline More Than Doubled Chances of Quitting E-Cigarettes J Am Med Assoc (JAMA)
  Millions of young people currently use e-cigarettes, according to recent data. However, there are few evidence-backed strategies to help people stop vaping. Now, a double-blind randomized study published in JAMA Internal Medicine suggests that a drug known as cytisinicline might also help curb (…)
• 02:00
  Poll: Health-Related Costs Top Older Adults’ Concerns J Am Med Assoc (JAMA)
  When asked about their feelings on more than 20 topics, older adults listed various health-related costs as their top 6 concerns, based on data from about 3400 respondents to the University of Michigan’s National Poll on Healthy Aging. The majority of respondents aged 50 years or older were (…)
• 02:00
  WHO: As Mpox Outbreaks Continue, Cases May Be Underestimated J Am Med Assoc (JAMA)
  About 2 years after the global mpox outbreak began, the World Health Organization (WHO) provided updated numbers of mpox cases and revised vaccine recommendations in a new situation report. From 2022 through March 2024, more than 95 200 people have developed mpox infections and 185 patients have (…)
• 02:00
  JAMA J Am Med Assoc (JAMA)
• 02:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 02:00
  Benefit of RAS Blockade in Heart Failure by Race J Am Med Assoc (JAMA)
  This meta-analysis assesses whether Black patients with heart failure and reduced ejection fraction respond differently than patients of other races to renin-angiotensin system (RAS) blockade by examining individual patient data from randomized clinical trials.
• 02:00
  Needlework at the Hospital J Am Med Assoc (JAMA)
  This is the beginning of something for yourself for once, a summer afghan, a simple little throw for meditation,
• 02:00
  Mimesis: Poetry and Imitating Medicine J Am Med Assoc (JAMA)
  Mimesis in poetry is the imitation or re-creation of reality using art. Thinkers ranging from Aristotle to Adorno have wondered at this human capacity to symbolize, and how it helps us make our own sense of, and express to others, both our external and internal worlds. In the poem “Needlework at (…)
• 02:00
  Review: Chronic Pruritus J Am Med Assoc (JAMA)
  This narrative review summarizes current evidence regarding diagnosis and treatment of chronic pruritus.
• 02:00
  Evidence Against Use of Nitrogen for the Death Penalty J Am Med Assoc (JAMA)
  This Viewpoint discusses the recent use of forced nitrogen inhalation as capital punishment in Alabama and describes the body of evidence indicating that forced nitrogen inhalation is an inhumane practice.
• 02:00
  Pediatric Phoenix Sepsis Score Challenges J Am Med Assoc (JAMA)
  To the Editor We read with great interest the article “International Consensus Criteria for Pediatric Sepsis and Septic Shock” and commend the authors for their dedication to standardizing and improving the care of children with sepsis. By using an empirical approach in a global cohort of (…)
• 02:00
  Pediatric Phoenix Sepsis Score Challenges—Reply J Am Med Assoc (JAMA)
  In Reply Ms Msefula and colleagues raise an important point regarding inclusion of tests and therapies in the Phoenix Sepsis Score that, based on the global survey performed by the Pediatric Sepsis Definition Task Force, may not be universally available. Msefula and colleagues have an associated (…)
• 02:00
  Long-Term Outcomes From Prostate Cancer Active Surveillance J Am Med Assoc (JAMA)
  This prospective, multicenter cohort study evaluates the long-term outcomes of men diagnosed with favorable-risk prostate cancer managed with protocol-directed active surveillance, including regular biopsies and prostate-specific antigen screening, from 2008 to 2022.
• 02:00
  Patient Information: Age-Related Macular Degeneration J Am Med Assoc (JAMA)
  This JAMA Patient Page describes age-related macular degeneration development and progression; symptoms and risk factors; and diagnosis, monitoring, and treatment.
• 02:00
  The Clinic Visit J Am Med Assoc (JAMA)
  In this narrative medicine essay, a surgical oncologist reflects on his 30-year practice and the care he receives for his leukemia, understanding how vital the relationships and discourse with the care team are for his recovery.
• 02:00
  The Texas Medical Board and the Futility of Medical Exceptions to Abortion Bans J Am Med Assoc (JAMA)
  This Viewpoint describes the failure of yet another state institution to generate meaningful guidance about medical exceptions to abortion bans.
• 02:00
  Accounting for Competing Risks in Clinical Research J Am Med Assoc (JAMA)
  This JAMA Guide to Statistics and Methods article discusses accounting for competing risks in clinical research.
• 02:00
  Ransomware Attacks, ED Visits and Inpatient Admissions in Targeted and Nearby Hospitals J Am Med Assoc (JAMA)
  This case-control study analyzes disruptive ransomware attacks against hospitals in California from 2014 to 2020 and emergency department (ED) and inpatient admissions in attacked and nearby hospitals.

18 juin

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 02:00
  Advancing Access to Cell and Gene Therapies in Medicaid J Am Med Assoc (JAMA)
  This Viewpoint presents the components of the payment model and the implementation challenges among the Center for Medicare and Medicaid Innovation, state Medicaid agencies, patients, and manufacturers.
• 02:00
  FTC Oversight of the Pharmaceutical Industry J Am Med Assoc (JAMA)
  High drug prices in the US are a serious problem for both patients and the health care system. Prices of branded drugs are driven higher by monopoly dynamics: patents and other exclusive marketing rights allow companies to increase prices and restrict supply. Firms earn extraordinary profits (…)
• 02:00
  Krill Oil for Knee Osteoarthritis J Am Med Assoc (JAMA)
  This randomized clinical trial assesses the effect of krill oil supplementation vs placebo on knee pain improvement in patients with knee osteoarthritis, significant knee pain, and effusion-synovitis.
• 02:00
  A Good Prognosis J Am Med Assoc (JAMA)
  These are not the final few months of my life, not the last bowl of salad I add a few spoons of tuna and mayo to. I’m not going to die on a date printed in the calendar that hangs on my fridge with cheesy pictures of Yosemite and captions like Bike to Work Day. I can sit here at the kitchen (…)
• 02:00
  Time to IVT Treatment and Functional Outcomes in Acute Ischemic Stroke—Reply J Am Med Assoc (JAMA)
  In Reply We thank Drs Sedghi and Siepmann for their comments. Indeed, all trials included in our individual participant meta-analysis enrolled only patients directly presenting at thrombectomy-capable stroke centers. Hence, the data presented in our study are applicable only to this exact (…)
• 02:00
  Chronic Chagas Disease in the US J Am Med Assoc (JAMA)
  This JAMA Insights provides recommendations for Chagas disease screening, diagnosis, and management in the US
• 02:00
  Dispensing of Glucagon-Like Peptide-1 Receptor Agonists to Adolescents and Young Adults, 2020-2023 J Am Med Assoc (JAMA)
  This study uses data from US retail pharmacies to assess national GLP-1RA dispensing to adolescents and young adults from 2020-2023.
• 02:00
  Time to IVT Treatment and Functional Outcomes in Acute Ischemic Stroke J Am Med Assoc (JAMA)
  To the Editor A recent individual patient data meta-analysis of 6 randomized trials found that the beneficial effect of intravenous thrombolysis (IVT) before thrombectomy in patients with anterior-circulation large-vessel occlusion diminished with time from onset of stroke symptoms to (…)
• 02:00
  Social Isolation and Loneliness in Older Adults J Am Med Assoc (JAMA)
  This JAMA Patient Page discusses social isolation and loneliness as important public health concerns, especially among older adults.
• 02:00
  The Other Side of the Curtain J Am Med Assoc (JAMA)
  In this narrative medicine essay, a newly minted pediatric critical care physician learns firsthand what holistic medical care is from the love and attention she received during a hospitalization for mediastinal lymphoma.
• 02:00
  Heard but Excluded: A Language Manifesto J Am Med Assoc (JAMA)
  This Viewpoint discusses dismantling language barriers via multipronged approaches grounded in innovation, human-centered design, and systems thinking in 3 key areas.
• 02:00
  Phoenix Criteria for Pediatric Sepsis and Septic Shock J Am Med Assoc (JAMA)
  To the Editor We read Dr Sanchez-Pinto and colleagues’ study with interest, but we are concerned that the final Phoenix 4-organ model does not include acute kidney injury (AKI) assessment. Additionally, the Phoenix 8-organ model used only a single serum creatinine threshold. Despite inclusion of (…)
• 02:00
  Phoenix Criteria for Pediatric Sepsis and Septic Shock—Reply J Am Med Assoc (JAMA)
  In Reply We are grateful to Dr Thadani and colleagues for their interest in our work and applaud their efforts to improve outcomes from AKI around the world. We agree that AKI is important to assess and treat in children with sepsis in any environment and that children in some less-resourced (…)
• 02:00
  Shingles Vaccination in Medicare Part D After Inflation Reduction Act Elimination of Cost Sharing J Am Med Assoc (JAMA)
  This cross-sectional study uses data from retail pharmacies to examine shingles vaccine uptake among Medicare Part D beneficiaries following an IRA policy to eliminate cost sharing.
• 02:00
  How AI Will Augment Radiologists J Am Med Assoc (JAMA)
  This Medical News article is an interview with Saurabh Jha, a cardiothoracic radiologist and an associate professor of radiology at the University of Pennsylvania, and JAMA Editor in Chief Kirsten Bibbins-Domingo.
• 02:00
  Public Health Preparedness and Response to Avian Influenza A(H5N1) Viruses J Am Med Assoc (JAMA)
  US public health preparedness and response to highly pathogenic avian influenza A(H5N1) viruses are assessed in this survey study conducted by the CDC.
• 02:00
  Congress, the Doctor J Am Med Assoc (JAMA)
  Without a dissenting vote, the House of Delegates of the American Medical Association adopted last week a resolution calling on the Board of Trustees to use its best endeavors to have repealed such sections of the national prohibition acts as may interfere with the proper relation between the (…)
• 02:00
  Monoclonal Antibody Protected Majority of Children From Malaria J Am Med Assoc (JAMA)
  Current strategies to protect children from malaria—administration of new RTS,S/AS01 or R21/Matrix-M vaccines as well as seasonal medications—require about 20 health care visits by the time a child reaches age 5 years. However, an approach involving the annual administration of a monoclonal (…)
• 02:00
  HHS Commits Millions to Improving Maternal, Infant Health J Am Med Assoc (JAMA)
  The proportion of people who die while pregnant or within 42 days after their pregnancy ends has been steadily increasing in the US. Now, updated numbers from the National Vital Statistics System indicate promising trends in maternal mortality rates. About 22 people per 100 000 live births died (…)
• 02:00
  Lower Dose of Mpox Vaccine Was Safe, Effective J Am Med Assoc (JAMA)
  Intradermal injections that were one-fifth of the standard mpox vaccine dose generated antibody responses equivalent to those of subcutaneous injections of the standard dose at 6 weeks, based on results from 225 US adults aged 18 to 50 years. No participants experienced serious adverse events (…)
• 02:00
  New Drug for UTIs Gets the Greenlight J Am Med Assoc (JAMA)
  The US Food and Drug Administration recently approved pivmecillinam, sold as Pivya, for uncomplicated urinary tract infections (UTIs) in females aged 18 years or older with no structural abnormalities of their urinary tract. UTIs affect about 50% of females at some point during their life, the (…)
• 02:00
  Progress in Heart Failure Deaths Reversed Over Past Decade J Am Med Assoc (JAMA)
  Although heart failure mortality rates fell between 1999 and 2012, the proportion of people dying from the condition in the US has increased in recent years, according to a study published in JAMA Cardiology. By 2021, the heart failure mortality rate was higher than in 1999, signaling that (…)
• 02:00
  Federal Trade Commission Bans Noncompete Clauses J Am Med Assoc (JAMA)
  Up to 45% of physicians are subject to noncompete clauses, contractual requirements that can prevent them from changing jobs, which can limit competition and access to care, according to the American Medical Association. However, employers will no longer be allowed to enforce noncompete clauses (…)
• 02:00
  Blood Pressure Drugs Linked to More Fractures, Falls in VA Nursing Homes J Am Med Assoc (JAMA)
  Long-term Veterans Health Administration (VA) nursing home residents who started new medications to treat high blood pressure were more than twice as likely to experience a fracture than those who did not, according to a cohort study involving more than 29 600 VA participants, almost all male, (…)
• 02:00
  Monoclonal Antibody Authorized to Protect At-Risk People From COVID-19 J Am Med Assoc (JAMA)
  The US Food and Drug Administration (FDA) granted emergency use authorization to pemivibart, marketed as Pemgarda, to protect people who are immunocompromised from COVID-19. Pemivibart is the only long-acting monoclonal antibody available in the US for preexposure prophylaxis after the FDA (…)
• 02:00
  Microneedle Vaccine Patches Generated Immune Response in Children J Am Med Assoc (JAMA)
  People who received a microneedle patch that delivered a measles and rubella vaccine mounted immune responses that were equivalent to those vaccinated via subcutaneous injection, according to data from a randomized clinical trial involving 285 participants from The Gambia, including 240 toddlers (…)
• 02:00
  Maintenance of Certification’s Value to Patients and Physicians—Reply J Am Med Assoc (JAMA)
  In Reply We appreciate the Letter by Drs Stern and Hafferty about our recent Viewpoint, which gave priority to highlighting the large and growing body of evidence that patients of physicians who demonstrate more medical knowledge have better prognoses on a host of important outcomes. In doing (…)
• 02:00
  Federal Trade Commission Actions on Prescription Drugs, 2000-2022 J Am Med Assoc (JAMA)
  This Special Communication examines the Federal Trade Commission’s policy and legal actions related to alleged misconduct, consolidation, and anticompetitive behavior in the pharmaceutical market between 2000 and 2022.
• 02:00
  Blood Testing for Phosphatidylethanol J Am Med Assoc (JAMA)
  A 36-year-old man with obesity and dyslipidemia presented with elevated liver enzymes following a liver transplant to treat acute-on-chronic liver failure due to alcohol-associated hepatitis. What would you do next?
• 02:00
  Risks of Harm in Alzheimer Disease by Amyloid Lowering J Am Med Assoc (JAMA)
  This Viewpoint discusses how data gaps in published research impede clinicians’ ability to clearly discuss the risks and benefits of amyloid-lowering drugs for treating Alzheimer disease.
• 02:00
  Harnessing the Electronic Health Record to Improve Empiric Antibiotic Prescribing J Am Med Assoc (JAMA)
  Approximately half of hospitalized adults in the US receive antibiotics, with pneumonia and urinary tract infection (UTI) being the 2 most frequent indications. Estimates suggest about 30% of all antibiotics prescribed in US hospitals are either unnecessary or suboptimal, and extended-spectrum (…)
• 02:00
  Stewardship Prompts to Improve Antibiotic Selection for Pneumonia J Am Med Assoc (JAMA)
  This clinical trial examines the effect of an antibiotic stewardship bundle (education, feedback, and real-time multidrug-resistant organism risk-based CPOE prompts) vs routine stewardship on antibiotic selection during the first 3 hospital days in adults with pneumonia.
• 02:00
  Stewardship Prompts to Improve Antibiotic Selection for Urinary Tract Infection J Am Med Assoc (JAMA)
  This clinical trial evaluates whether computerized provider order entry prompts providing patient- and pathogen-specific multidrug-resistant organism risk estimates could reduce use of empiric extended-spectrum antibiotics for treatment of urinary tract infections.
• 02:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 02:00
  JAMA J Am Med Assoc (JAMA)
• 02:00
  Maintenance of Certification’s Value to Patients and Physicians J Am Med Assoc (JAMA)
  To The Editor The American Board of Internal Medicine (ABIM) has an outsized influence as the arbiter of internal medicine physician quality, given the alternatives of minimal state regulations, spotty insurance-based estimates, and random patient-based ratings. A recent Viewpoint responded to (…)

11 juin

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 02:00
  Toward More Equitable Breast Cancer Outcomes J Am Med Assoc (JAMA)
  In its revised Recommendation Statement, the US Preventive Services Task Force (USPSTF) now recommends that all women undergo routine breast cancer screening every other year beginning at age 40 years. This is an adjustment from the 2016 recommendation for all women to start at age 50 and for (…)
• 02:00
  USPSTF Report: Collaborative Modeling to Compare Breast Cancer Screening Strategies J Am Med Assoc (JAMA)
  This modeling study uses Cancer Intervention and Surveillance Modeling Network models and national data on breast cancer incidence, mammography performance, treatment effects, and other-cause mortality in US women without previous cancer diagnoses to estimate outcomes of various mammography (…)
• 02:00
  Apixaban to Prevent Recurrence After Cryptogenic Stroke J Am Med Assoc (JAMA)
  To the Editor A recent clinical trial demonstrated that apixaban did not significantly reduce recurrent stroke risk compared with aspirin in patients with cryptogenic stroke and evidence of atrial cardiopathy without atrial fibrillation. However, we had some concerns about this study. First, it (…)
• 02:00
  Apixaban to Prevent Recurrence After Cryptogenic Stroke J Am Med Assoc (JAMA)
  To the Editor The recent Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke (ARCADIA) trial did not demonstrate superiority of apixaban over aspirin for secondary prevention in patients with cryptogenic stroke and atrial cardiopathy. In this study, atrial (…)
• 02:00
  Apixaban to Prevent Recurrence After Cryptogenic Stroke—Reply J Am Med Assoc (JAMA)
  In Reply In response to our recent article, Dr Chi and colleagues raise an important point regarding uncertainty about optimal biomarkers of atrial cardiopathy. Compared with ARCADIA patients who qualified for enrollment in our study only by the NT-proBNP criterion, those who qualified by only (…)
• 02:00
  Poetry and the Meaning of Care J Am Med Assoc (JAMA)
  Health care is becoming more and more distanced. Clinicians must overcome not just mountains of data, burdensome electronic health records, and ever-increasing numbers of machines that separate us from patients, but more recently also navigate telemedicine and AI-driven chatbots. (…)
• 02:00
  Can Cardiovascular Risk Assessment Be Improved in the 21st Century? J Am Med Assoc (JAMA)
  Cardiovascular risk assessment has become an essential part of preventive strategies designed to target risk factor interventions and has contributed to dramatic reductions in cardiovascular disease mortality during the past 60 years in the US and other countries. Beginning in the 1960s, (…)
• 02:00
  Autoantibody Profile Emerged Years Before Multiple Sclerosis Diagnosis J Am Med Assoc (JAMA)
  About 10% of people with multiple sclerosis (MS) had an autoantibody signature that was present at least 5 years before symptoms, according to an analysis of blood samples from 500 military service members. Researchers collected the first sample an average of 5 years before some participants (…)
• 02:00
  Patients Treated by Female Physicians Had Better Mortality Rates J Am Med Assoc (JAMA)
  Hospitalized patients in the US tended to have a lower chance of dying or being readmitted within 30 days when they were treated by female physicians rather than male clinicians, a recent study published in Annals of Internal Medicine found. The difference in outcomes for patients examined by (…)
• 02:00
  The Challenge of the Computer J Am Med Assoc (JAMA)
  The average physician is unlikely to build a computer in his basement from a kit. But the principles of computer analysis are not difficult to master. Evidence of the growing importance of these complex electronic machines is found in the announcement that the potential of the computer in (…)
• 02:00
  AI-Generated Clinical Summaries J Am Med Assoc (JAMA)
  To the Editor In their recent Viewpoint, Dr Goodman and colleagues examined artificial intelligence (AI)–generated clinical summaries and identified concerns regarding variability, bias, and single-word errors in their AI summaries generated through the ChatGPT model. However, it must be noted (…)
• 02:00
  AI-Generated Clinical Summaries—Reply J Am Med Assoc (JAMA)
  In Reply We thank Ms Chen and Dr Thornton for their interest in our Viewpoint examining potential benefits and challenges of AI-generated clinical summaries. We fully agree that future studies should evaluate how AI summaries influence physician decision-making and clinical outcomes. We (…)
• 02:00
  Antipsychotics for Dementia Tied to More Serious Harms Than Expected J Am Med Assoc (JAMA)
  Prior research has suggested that antipsychotic drugs might be overprescribed for people with dementia, despite known risks of stroke and sudden cardiac death. Now, findings from a new study in The BMJ indicate that the range of serious adverse outcomes associated with antipsychotics in these (…)
• 02:00
  WHO Updates Terminology for Pathogens That Spread Through the Air J Am Med Assoc (JAMA)
  A multiyear global collaboration among public health agencies has led to new terminology for pathogens such as SARS-CoV-2 that can spread through the air, the World Health Organization (WHO) announced. The report by the WHO and partners, including the US Centers for Disease Control and (…)
• 02:00
  Pregnancy Complications Tied to Higher Risk of Death Decades Later J Am Med Assoc (JAMA)
  Pregnant people who experienced adverse pregnancy outcomes had up to a 50% increased risk of dying from any cause up to 46 years after giving birth, according to data from a cohort study involving about 2.2 million participants from Sweden who gave birth between 1973 and 2015. Cardiovascular and (…)
• 02:00
  New HHS Rule Strengthens Privacy Around US Reproductive Care J Am Med Assoc (JAMA)
  The US Department of Health and Human Services (HHS) recently announced a final rule that increases privacy protections for people seeking legal reproductive care, such as an abortion, either in their home state or by traveling to another one. The modification to the Health Insurance Portability (…)
• 02:00
  Changes to Medicare, Medicaid Coverage Could Cause Thousands of Deaths J Am Med Assoc (JAMA)
  Some policymakers have suggested increasing the eligibility age for Medicare and implementing work requirements for Medicaid coverage to reduce US health care costs. However, a recent analysis involving data projections from the Census Bureau suggests that the proposed changes would cost (…)
• 02:00
  CMS Finalizes Staffing Minimum Requirements for Nursing Homes J Am Med Assoc (JAMA)
  The US Centers for Medicare & Medicaid Services (CMS) recently finalized a rule establishing the first minimum staffing requirements for nursing homes after an earlier version was proposed last September. The new rule will “hold nursing homes accountable for providing safe and (…)
• 02:00
  Late-Stage Cancer End Points to Speed Cancer Screening Clinical Trials—Not So Fast J Am Med Assoc (JAMA)
  In this issue of JAMA, Feng et al studied whether late-stage cancer (ie, stage III or stage IV cancer), rather than cancer-specific mortality, was an acceptable alternative end point in clinical trials of cancer screening. The authors analyzed 41 clinical trials conducted in Europe, North (…)
• 02:00
  USPSTF Recommendation: Screening for Breast Cancer J Am Med Assoc (JAMA)
  This 2024 Recommendation Statement from the US Preventive Services Task Force recommends biennial screening mammography for women aged 40 to 74 years (B recommendation) and concludes that evidence is insufficient to assess the balance of benefits and harms of screening mammography in women 75 (…)
• 02:00
  Screening for Breast Cancer J Am Med Assoc (JAMA)
  In this JAMA Patient Page, the US Preventive Services Task Force provides a guide to screening for breast cancer.
• 02:00
  USPSTF Review: Screening for Breast Cancer J Am Med Assoc (JAMA)
  This systematic review to support a 2024 US Preventive Services Task Force Recommendation Statement summarizes published evidence on the benefits and harms of screening for breast cancer in adult females.
• 02:00
  The State of State Biomarker Testing Insurance Coverage Laws J Am Med Assoc (JAMA)
  This Viewpoint discusses laws mandating insurance coverage of biomarker testing to broaden access to care for patients with cancer.
• 02:00
  When Is It Best to Begin Mammograms, and How Often? J Am Med Assoc (JAMA)
  This Medical News story discusses new USPSTF recommendations about the timing of screening mammograms.
• 02:00
  Prognostic Value of Cardiovascular Biomarkers in the Population J Am Med Assoc (JAMA)
  This study evaluates the prognostic value of routinely available cardiovascular biomarkers when added to established risk factors in the identification of individuals at high risk for atherosclerotic cardiovascular disease.
• 02:00
  Apixaban to Prevent Recurrence After Cryptogenic Stroke J Am Med Assoc (JAMA)
  To the Editor We have several concerns about the recent trial that examined apixaban for prevention of recurrence after cryptogenic stroke in patients with atrial cardiopathy.
• 02:00
  Mortality in Patients Hospitalized for COVID-19 vs Influenza in Fall-Winter 2023-2024 J Am Med Assoc (JAMA)
  This cohort study evaluates the risk of death in patients hospitalized for COVID-19 or seasonal influenza following the emergence of the JN.1 variant in winter 2023.
• 02:00
  Even Joy J Am Med Assoc (JAMA)
  Since her birth with half a brain The doctors have been kind, So awed by her determination they loan a private Room for the transient child to be and Show the worth of being Even if
• 02:00
  Fosamax Fractures J Am Med Assoc (JAMA)
  This Viewpoint discusses the ongoing lawsuit between plaintiffs who had been affected by atypical femoral fractures while receiving alendronate and the drug manufacturer.
• 02:00
  Cancer Stage Compared With Mortality as End Points in Randomized Clinical Trials of Cancer Screening J Am Med Assoc (JAMA)
  This meta-analysis of 41 randomized clinical trials of cancer screening compares cancer-specific mortality with stage III-IV cancer as end points.
• 02:00
  I Kept Crying J Am Med Assoc (JAMA)
  In this narrative medicine essay, a second-year pediatric resident bears the scars from the terror that descended the moment of her son’s birth at 31 weeks’ gestation, terror relived even after he has come home healthy.
• 02:00
  Combined COVID-19 and Flu Vaccines Could Be Available Next Year J Am Med Assoc (JAMA)
  This Medical News story discusses the development of experimental combination vaccines for adults.
• 02:00
  “Inoculation” to Resist Misinformation J Am Med Assoc (JAMA)
  This JAMA Insights in the Communicating Medicine series explores the concept of “prebunking,” a psychological inoculation technique that could help prevent the spread of misinformation.
• 02:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 02:00
  JAMA J Am Med Assoc (JAMA)
• 02:00
  Urine-Based Test Could Help Identify Aggressive Prostate Cancer J Am Med Assoc (JAMA)
  A urine-based test involving 18 genes was more accurate at diagnosing high-grade prostate cancer than existing biomarker tests such as blood levels of prostate-specific antigen (PSA), according to a recent study published in JAMA Oncology.