24 juin

J Am Soc Nephrol https://jasn.asnjournals.org/

• 07:00
  Potassium-Alkali–Enriched Diet, Hypertension, and Proteinuria following Uninephrectomy - Ralph, Donna L.; Ha, Darren; Lei, Hillmin; Priver, Taylor S.; Smith, Scotti D.; McFarlin, Brandon E.; Schwindt, Seth; Pandya, Drishti; Koepsell, Hermann; Pastor-Soler, Nuria M.; Edwards, Aurelie; McDonough, Alicia A. J Am Soc Nephrol
  Background: Losing or donating a kidney is associated with risks of developing hypertension and albuminuria. Few studies address mechanisms or interventions. We investigate potential benefits of a K+- alkali–enriched diet and the mechanisms underlying proteinuria. Methods: Male Sprague Dawley (…) -- Original Article: Acid Base and Electrolyte Disorders
• 07:00
  Angiotensin-II-Type-1a Receptor (AT1aR) and Renal K+ Wasting during Overnight Low-Na+ Intake - Duan, Xin-Peng; Zheng, Jun-Ya; Xiao, Yu; Zhang, Cheng-Biao; Lin, Dao-Hong; Wang, Wen-Hui J Am Soc Nephrol
  Background: Chronic Angiotensin-II (Ang-II) perfusion stimulates Kir4.1/Kir5.1 of the DCT via angiotensin-II-type-1a-receptor (AT1aR) and low-sodium-intake also stimulates Kir4.1/Kir5.1. However, it is not explored the role of AT1aR in mediating the effect of LS on Kir4.1/Kir5.1. Methods: We (…) -- Original Article: Acid Base and Electrolyte Disorders

18 juin

J Am Soc Nephrol https://jasn.asnjournals.org/

• 07:00
  Evolutionary Differences in Uric Acid Metabolism Inform about the Risks of Pig-to-Human Kidney Transplant - Percudani, Riccardo; Capelli, Cristian; Sassi, Giulia; Mori, Giulia J Am Soc Nephrol
  No abstract available -- Perspective
• 07:00
  Association between Acute Declines in Estimated Glomerular Filtration Rate during Renin-Angiotensin System Inhibition and Risk of Adverse Outcomes - Ku, Elaine; Tighiouart, Hocine; McCulloch, Charles E.; Inker, Lesley A.; Adingwupu, Ogechi; Greene, Tom; Estacio, Raymond O.; Woodward, Mark; de Zeeuw, Dick; Lewis, Julia B.; Hannedouche, Thierry; Hou, Fan Fan; Jafar, Tazeen H.; Ima, Enyu; Remuzzi, Guiseppe; Heerspink, Hiddo J.L.; Toto, Robert D.; Sarnak, Mark J. J Am Soc Nephrol
  Background: Declines in glomerular filtration rate (GFR) occur commonly when renin-angiotensin system (RAS) inhibitors are started. Our objective was to determine the relation between declines in estimated GFR during trials of RAS inhibition and kidney outcomes. Methods: We included participants (…) -- Original Article: Chronic Kidney Disease
• 07:00
  Estimated Effect of Restarting Renin-Angiotensin System Inhibitors after Discontinuation on Kidney Outcomes and Mortality - Hattori, Koki; Sakaguchi, Yusuke; Oka, Tatsufumi; Asahina, Yuta; Kawaoka, Takayuki; Doi, Yohei; Hashimoto, Nobuhiro; Kusunoki, Yasuo; Yamamoto, Satoko; Yamato, Masafumi; Yamamoto, Ryohei; Matsui, Isao; Mizui, Masayuki; Kaimori, Jun-Ya; Isaka, Yoshitaka J Am Soc Nephrol
  Background: While renin-angiotensin system inhibitors (RASi) have been the mainstream treatment for patients with CKD, they are often discontinued due to adverse effects such as hyperkalemia and acute kidney injury. It is unknown whether restarting RASi after discontinuation improves clinical (…) -- Original Article: Chronic Kidney Disease

14 juin

J Am Soc Nephrol https://jasn.asnjournals.org/

• 07:00
  Inflammasomes and Acute Kidney Injury - Muruve, Daniel A. J Am Soc Nephrol
  No abstract available -- Editorial

12 juin

J Am Soc Nephrol https://jasn.asnjournals.org/

• 07:00
  The Plasma Metabolome and Risk of Incident Kidney Stones - Ferraro, Pietro Manuel; Li, Yukun; Balasubramanian, Raji; Curhan, Gary C.; Taylor, Eric N. J Am Soc Nephrol
  Background Information on metabolomic profiles in kidney stone formers is limited. To examine independent associations between plasma metabolomic profiles and the risk of incident, symptomatic kidney stones in adults, we conducted prospective nested case-control studies in two large cohorts. (…) -- Original Article: Acid Base and Electrolyte Disorders

10 juin

J Am Soc Nephrol https://jasn.asnjournals.org/

• 07:00
  No Time for Cancel Culture: The Importance of Banff Pathology Criteria and Clinical Outcomes - Mengel, Michael; Mannon, Roslyn B. J Am Soc Nephrol
  No abstract available -- Editorial
• 07:00
  METTL3-Mediated N6-methyladenosine mRNA Modification and cGAS-STING Pathway Activity in Kidney Fibrosis - Tsai, Yu-Cheng; Hsieh, Tsung-Han; Liao, Yuan-Ru; Tsai, Ming-Tsun; Lin, Tzu-Ping; Lee, Der-Yen; Park, Jihwan; Kim, Donggun; Susztak, Katalin; Yang, Shang-Feng; Lin, Chih-Ching; Li, Szu-Yuan J Am Soc Nephrol
  Background Chemical modifications on RNA profoundly impact RNA function and regulation. m6A, the most abundant RNA modification in eukaryotes, plays a pivotal role in diverse cellular processes and disease mechanisms. However, its importance is understudied in human chronic kidney disease (CKD) (…) -- Original Article: Genetics
• 07:00
  Kidney Volume and Risk of Incident Kidney Outcomes - Wu, Jianhan; Wang, Yifan; Vlasschaert, Caitlyn; Lali, Ricky; Feiner, James; Gaheer, Pukhraj; Yang, Serena; Perrot, Nicolas; Chong, Michael; Paré, Guillaume; Lanktree, Matthew B. J Am Soc Nephrol
  Background: Low total kidney volume (TKV) is a risk factor for chronic kidney disease (CKD). However, evaluations of nonlinear relationships, incident events, causal inference, and prognostic utility beyond traditional biomarkers are lacking. Methods: TKV, height-adjusted TKV, and body surface (…) -- Original Article: Chronic Kidney Disease

7 juin

J Am Soc Nephrol https://jasn.asnjournals.org/

• 07:00
  P2Y2R and Cyst Growth in Polycystic Kidney Disease - Kraus, Andre; Skoczynski, Kathrin; Brötsch, Martin; Burzlaff, Nicolai; Leipziger, Jens; Schiffer, Mario; Büttner-Herold, Maike; Buchholz, Bjoern J Am Soc Nephrol
  Key Points Polycystic kidney disease (PKD) is characterized by continuous cyst growth, which results in a decline in kidney function.Deletion of P2Y2R and pharmacological antagonism of purinergic signaling significantly reduced cyst growth in an orthologous PKD mouse model.P2Y2R was expressed in (…) -- Basic Research: Cystic Kidney Disease

6 juin

J Am Soc Nephrol https://jasn.asnjournals.org/

• 07:00
  Perceptions and Experiences of Gender Equity among Women in Academic Nephrology - Bansal, Nisha; Zelnick, Leila; Java, Anuja; Nicholas, Susanne B.; Curtis, Lisa M. J Am Soc Nephrol
  No abstract available -- Research Letter
• 07:00
  Glomerular Endothelial Cell Receptor ADGRF5 and the Integrity of the Glomerular Filtration Barrier - Nagase, Miki; Ando, Hikaru; Beppu, Yoshiaki; Kurihara, Hidetake; Oki, Souta; Kubo, Fumimasa; Yamamoto, Kazuki; Nagase, Takashi; Kaname, Shinya; Akimoto, Yoshihiro; Fukuhara, Hiroshi; Sakai, Tatsuo; Hirose, Shigehisa; Nakamura, Nobuhiro J Am Soc Nephrol
  Background: Glomerular endothelial cells are recognized to be important for maintaining the glomerular filtration barrier. ADGRF5, an adhesion G protein-coupled receptor, has been suggested to be involved in endothelial cell function. However, the role of ADGRF5 in the glomerular filtration (…) -- Original Article: Normal Kidney Structure and Function
• 07:00
  Authors' Reply: Dialysate Sodium and Mortality: One Size Does Not Fit All - Pinter, Jule; Smyth, Brendan; Jardine, Meg J Am Soc Nephrol
  No abstract available -- Letter to the Editor
• 07:00
  Serum and Urine Metabolites and Kidney Function - Yeo, Wan-Jin; Surapaneni, Aditya L.; Hasson, Denise; Schmidt, Insa M.; Sekula, Peggy; Köttgen, Anna; Eckardt, Kai-Uwe; Rebholz, Casey M.; Yu, Bing; Waikar, Sushrut S.; Rhee, Eugene P.; Schrauben, Sarah J.; Feldman, Harold I.; Vasan, Ramachandran S.; Kimmel, Paul L.; Coresh, Josef; Grams, Morgan E.; Schlosser, Pascal J Am Soc Nephrol
  Background Metabolites represent a read-out of cellular processes underlying states of health and disease. Methods We evaluated cross-sectional and longitudinal associations between 1255 serum and 1398 urine known and unknown (denoted with “X” in name) metabolites (Metabolon HD4, 721 detected in (…) -- Original Article: Chronic Kidney Disease
• 07:00
  Authors' Reply: Utility of Urinary CD4+ T-Cell Count in Detecting ANCA-Associated Vasculitis Renal Relapse - Prskalo, Luka; Schreiber, Adrian; Enghard, Philipp J Am Soc Nephrol
  No abstract available -- Letter to the Editor
• 07:00
  Utility of Urinary CD4+ T-Cell Count in Detecting ANCA-Associated Vasculitis Renal Relapse - Brousse, Romain; Boudhabhay, Idris; Duong Van Huyen, Jean-Paul; Karras, Alexandre J Am Soc Nephrol
  No abstract available -- Letter to the Editor
• 07:00
  Authors' Reply: Phosphate Depletion Mobilizes Bone Bicarbonate - Egli-Spichtig, Daniela; Wagner, Carsten Alexander; Hamid, Ahmad Kamal J Am Soc Nephrol
  No abstract available -- Letter to the Editor
• 07:00
  Phosphate Depletion Mobilizes Bone Bicarbonate - Emmett, Michael J Am Soc Nephrol
  No abstract available -- Letter to the Editor
• 07:00
  Authors' Reply: Dialysate Sodium and Mortality: 140 mmol/L at Hemodialysis Initiation by Default? - Pinter, Jule; Jardine, Meg; Canaud, Bernard; Genser, Bernd J Am Soc Nephrol
  No abstract available -- Letter to the Editor
• 07:00
  Dialysate Sodium and Mortality: 140 mmol/L at Hemodialysis Initiation by Default? - Hecking, Manfred; Karaboyas, Angelo; Krenn, Simon; Mussnig, Sebastian; Beige, Joachim; Chazot, Charles; Pecoits-Filho, Roberto; Rayner, Hugh; Port, Friedrich K. J Am Soc Nephrol
  No abstract available -- Letter to the Editor

3 juin

J Am Soc Nephrol https://jasn.asnjournals.org/

• 07:00
  Long Noncoding RNAs in Single Cells - Qiu, Qiongzi; Liang, Mingyu J Am Soc Nephrol
  No abstract available -- Editorial