500 posts

20 May

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

02:00
Correction to: Independent effects of parathyroid hormone and phosphate levels on hard outcomes in non-dialysis patients: food for thought - Torres P, Troya M, Dauvergne M, et al. Nephrol Dial Transplant

3 May

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

02:00
MO510: CKD Progression in a Cohort of Older Community-Dwelling Adults– Results From the Berlin Initiative Study (BIS) - Bothe T, Schaeffner E, Mielke N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSData on the estimated glomerular filtration rate (eGFR) over time in older populations are scarce. Identifying patterns of eGFR progression is essential for a better understanding of chronic kidney disease (CKD) in older adults.METHODWe used data from the BIS, a (...)
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MO392: Mildly Impaired Kidney Function May Be Associated With the Risk of Hippocampal Atrophy in Young and Midlife Adults - Gadalean F, Virdol M, Schiller A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSTo date, associations between kidney function and brain structural abnormalities have been described in several studies [1]. Reports of renal function in relation to hippocampal atrophy have been scarce and the majority of studies have been focussed on older end-stage (...)
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MO427: Protein Arginine Methyltransferase 1 Increases The Expression of P63 and Promotes Renal Interstitial Fibrosis - Ye C, Lin J, Wu M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMammalian Protein Arginine Methyltransferase 1 (PRMT1) catalyzes the monomethylation and dimethylation of the Arginine residues of proteins. It has been shown that PRMT1 inhibitor attenuates renal fibrosis, however, the role of PRMT1 in renal interstitial fibrosis is (...)
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MO428: Fibrosis Markers, But Not Circulating Autotaxin (ATX) or Lysophosphatidic Acid (LPA) Associate With Disease Progression in Diabetic Kidney Disease (DKD) - Garcia Cossio E, Nowotny B, Afhueppe W, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSDiabetic kidney disease (DKD) remains the most common cause of the end-stage renal disease (ESRD) worldwide. Kidney fibrosis predicts functional decline and ESRD in many, but not all patients [1]. Autotaxin (ATX) is the enzyme converting lysophosphatidylcholine to (...)
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MO429: The Association of Circulating Monocytes Subsets, NK Cells and Lymphocyte Subpopulations With Conventional and Novel Deformation Indices of Left Ventricular Function in CKD Patients With No Established Cardiovascular Disease - Duni A, Lakkas L, Bechlioulis A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCardiovascular disease (CVD) and chronic kidney disease (CKD) are closely interrelated. Adverse immune responses have been implicated in the pathogenesis of both CVD and CKD [1, 2]. Monocyte subsets are key in atherogenesis and the inflammatory cascade occurring in (...)
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MO430: Octogenarians Referred to the Nephrologist: Evolution and Progression Risk Factors - Frías González A, Vargas F, Berzal Rico R, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe actual definition of chronic kidney disease (CKD) applied to patients ?80 years has generated an increase in the number of referrals to Nephrology for consultation. Nowadays there is a debate about the evolution of kidney function in elderly patients, from (...)
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MO455: Fatty Acid-Associated Albumin Induces Proliferation and Senescence of Proximal Tubular Cells - Kurosaki Y, Nielsen R, Ouchi M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSProteinuria is a major risk factor for the progression of chronic kidney disease. Protein overload in the proximal tubular epithelial cells causes oxidative stress, lysosomal dysfunction, inflammation and apoptosis, resulting in proximal tubule dysfunction. Recent (...)
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MO456: Renal and Major Clinical Outcomes After Nephrectomy in Patients With Pre-Existing Chronic Kidney Disease (ON-CKD Study) - Schleef M, Roy P, Paparel P, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPartial nephrectomy (PN) has progressively replaced radical nephrectomy (RN) whenever feasible for renal tumors. However, its effects on renal outcomes are less known in patients with pre-existing chronic kidney disease (CKD) or with solitary kidney (SK). We aimed to (...)
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MO457: Diffusion-MRI Predicts Decline of Renal Function in Chronic Kidney Diseases and Kidney Allograft Patients - Berchtold L, Crowe L, Combescure C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSKidney cortical interstitial fibrosis is highly predictive of renal prognosis and is currently assessed by the evaluation of a biopsy. Diffusion-weighted magnetic resonance imaging is a promising non-invasive tool to evaluate kidney fibrosis. We recently adapted a (...)
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MO458: Superb Micro-Vascular Imaging: An Innovative Ultrasound Technique for Early Detecting of Renal Damage - Armaly Z, Abu-Rahme M, Kinaneh S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSNovel ultrasound (US) methods are required to assess qualitative alterations in renal tissue. Superb microvascular imaging (SMI) is an innovative US technique designed for imaging and better visualization of micro-vascularization unseen with color Doppler US. We (...)
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MO503: Cognitive Performance in Patients With Chronic Kidney Disease: Results From the CKD-Rein Cohort Study - Pepin M, Boucquemont J, Turinici M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is a risk factor for cognitive impairment. In the general population, many risk factors have been reported in association with incident major neurocognitive disorders. The link between CKD and cognitive dysfunction is not completely (...)
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MO504: Urinary Albumin Excretion and Cancer Risk - Luo L, Kieneker L, van der Vegt B, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAccumulating evidence has shown that chronic kidney disease (CKD) is associated with cancer development. However, the main focus in these studies was on patients with moderately or severely impaired kidney function, rather than on patients with milder CKD defined by (...)
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MO505: Prevalence of Lupus Nephritis Among Patients With Systemic Lupus Erythematosus In Germany - Hunnicutt J, Schultze M, Garal-Pantaler E, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSLupus nephritis (LN) is the most common severe manifestation of systemic lupus erythematosus (SLE) and can lead to end-stage renal disease and death. However, there are limited data to contextualize the burden of LN in Germany, with no published studies using national (...)
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MO506: Disparities in Hospitalisation Rates Between Men and Women With and Without Chronic Kidney Disease in the Irish Health System - Stack A, Glynn L, Walsh C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIt is increasingly recognized that disparities in health care utilisation and associated clinical outcomes exist between men and women. Whether these sex disparities extend to patients with chronic kidney disease (CKD) is not well known. The primary goal of this study (...)
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MO507: Prediction of CKD Progression and Cardiovascular Events Using Pulse Wave Velocity and Albuminuria - Carlsen R, Sherzad Khatir D, Jensen D, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease (CVD) and death. Albuminuria has been identified as a risk factor, however, additional biomarkers predicting CKD progression and CVD are needed. Arterial stiffness is an easily (...)
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MO508: Estimated Glomerular Filtration Rate and the Risk of Inflammatory Bowel Disease in Adults: A Swedish Population-Based Study - Yang Y, Ludvigsson J, Olén O, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) and inflammatory bowel disease (IBD) share many risk factors. While kidney complications are seen in 4%–23% of patients with longstanding IBD, it is unknown whether low kidney function may predispose to developing IBD.METHODWe analyzed the (...)
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MO509: Reveal-CKD: Prevalence of Undiagnosed Stage 3 Chronic Kidney Disease Italy - De Nicola L, Peach E, Barone S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is a serious progressive disease with a substantial impact on global health that affects ?10% of the world's population. However, CKD remains largely under-recognized. Effective actions to slow disease progression and improve outcomes (...)
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MO330: AKI and Renal Parenchyma Attenuation in Hospitalized Patients With COVID-19 - Russo E, Tagliafico A, Signori A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had a worldwide spread since early 2020 and a lot of studies concerning the diagnostic and prognostic role of chest computed tomography (CT) on coronavirus disease (COVID-19) has been published. Renal (...)
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MO319: AKI in Patients With COVID-19 Supported on ECMO: A Single Center Experience in Mexico - Rizo Topete L, Gomez R, Contreras V, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAKI is a common complication in critically ill patients, during the COVID-19 pandemic, it has been presented directly associated with damage by the virus, due to the severity of the disease and secondary to treatment, that is, secondary to the crosstalk of organs and (...)
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MO320: Risk Factors and Outcomes Related to Acute Kidney Injury Among Enhanced Recovery After Surgery (ERAS) Colorectal Surgery - Fernandes A, Ribeiro D, Carvalho S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSEnhanced recovery after surgery (ERAS) protocol is an evidence-based programme that englobe more restrictive fluid therapy to maintain euvolemia and the use of multimodal analgesia, which includes non-steroidal anti-inflammatory drugs (NSAIDs). Consequently, it's (...)
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MO292: Clinical Characteristics, Management and Outcomes of Critically ill COVID-19 Patients Undergoing CRRT: Comparison Between the First Two Pandemic Waves - Cappadona F, Sangregorio F, Costa E, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a common complication of coronavirus disease-19 (COVID-19), which, particularly in critically ill patients requiring continuous renal replacement therapy (CRRT), is associated with an elevated mortality risk [1, 2]. However, knowledge (...)
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MO317: The Impact of Early Versus Late Initiation of Renal Replacement Therapy in Critically ill Patients With Acute Kidney Injury on Mortality and Clinical Outcomes: A Systematic Review With Meta-Analysis - Relvas M, Castro I, Gameiro J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRenal replacement therapy (RRT) is consensual in the presence of life-threatening complications associated with acute kidney injury (AKI). In the absence of urgent indications, the optimal timing for RRT initiation is still under debate. This systematic review with (...)
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MO325: Renal Glycosuria in Acute Kidney Injury Predicts the Diagnosis of Acute Interstitial Nephritis - Landaluce Triska E, Shabaka A, León-Póo M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute interstitial nephritis (AIN) is one of the most frequent causes of acute kidney injury (AKI). Interstitial inflammation can lead to tubular epithelial infiltration producing tubular dysfunction, which could be clinically detected by glycosuria (with or without (...)
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MO300: Subclinical AKI And Clinical Outcomes in Elderly Patients Undergoing Cardiac Surgery: Diagnostic Utility of NGAL - Marcello M, Maria Virzi G, Milan Manani S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAKI is a common and serious post-operative complication in patients undergoing cardiac surgery, and its incidence is particularly high among elderly patients. Cardiac surgery-associated AKI (CSA-AKI) represents the second most common cause of AKI in the intensive care (...)
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MO311: Acute Kidney Injury in Leukaemia Patients Submitted to Allogeneic Haematopoietic Stem Cell Transplant—Incidence and Risk Factors: A Cohort Analysis - Rodrigues N, Costa C, Branco C, et al. Nephrol Dial Transplant

AbstractBACKGROUNDStudies on acute kidney injury (AKI) in hematopoietic stem cell transplant (HSCT) consider several haematologic diagnoses in their cohorts and heterogeneous definitions for AKI not taking into consideration urinary output (UO). We aimed to evaluate the incidence and risk (...)
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MO331: Acute Kidney Failure as a Risk Factor for Longer Hospital Stay, Renal Replacement Therapy and Mortality: A Public Health System Analysis - Portoles J, Lopez P, De Valdenebro Recio M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney failure (AKI) is a well-known risk factor in coronary care unit (CCU) and postoperative patients. We aim to analyse their role in a multicentre database (DB) from a public regional health system (6 million inhabitants).METHODObservational, retrospective (...)
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MO334: Incidence of AKI Among Hospitalized COVID-19 Patients During the First and Sixth Waves of the Pandemic - Ardura P, Lorenzo A, Martínez Manrique M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSDuring the last 2 years, we have witnessed several waves of the COVID-19 pandemic characterized by massive infections among the general population, sudden increases in the number of hospitalizations and variable rates of complications and mortality among (...)
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MO335: Reaching SCR 4.0 mg/dL, the Magical Number for KDIGO-2012 AKI Stage 3. Is it Adequate for Stratifying Severity of Acute on Chronic Kidney Disease? - Acosta-Ochoa I, Lorenzo A, Coca A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSReaching a SCr ? 4 is one criterion of classification for stage 3 in the KDIGO-2012 AKI guidelines. No previous study has challenged this arbitrary cut point by comparing its performance on how patients with pure AKI (pAKI) versus acute on chronic kidney disease (...)
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MO377: Correlation Between 24-H Proteinuria and Spot Urine Albumin-Creatinine Ratio in Biopsy-Proven Glomerular Diseases - Díaz Enamorado Y, Shabaka A, Dominguez Torres P, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe gold standard for measurement of protein excretion is a 24-h urine collection. However, due to the cumbersome nature as well as the frequent errors in sample collection, it has been suggested that the measurement of albumin-creatinine ratio (ACR) in a spot urine (...)
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MO378: The Importance of Community Pharmacy in Chronic Kidney Disease Patient Management. Drug Dosage Adjustment and Nephrotoxicity Detection - Cámara Ramos I, Escribá Martí G, Escudero Quesada V, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is a common problem in patients over 60 years of age. It´s necessary to control the administration of nephrotoxic drugs and to adjust the dosage of drugs eliminated by kidneys. Community pharmacists can improve risk stratification and (...)
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MO403: The Association Between Urinary 11-Dehydrothromboxane B2 and Laboratory Parameters in Aspirin-Treated Patients With Cardiorenal Syndrome - Lukianets K, Vasilkova V, Pchelin I, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSEvaluation of urinary levels of the 11-dehydrothromboxane B2 is one of the methods for assessing platelet reactivity while taking aspirin. High levels of 11-dehydrothromboxane B2 in urine indicate continued thromboxane generation which is associated with an increased (...)
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MO404: Autophagy and Fibrotic Response is Genetically Determined in Mouse Mesangial Cells - Manzeger A, Mikone K, Mozes M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSC57Bl6/J (B6) mouse strain is resistant to several experimental models of renal fibrosis. Mesangial cells play an important role in the pathogenesis of glomerulosclerosis. Also, autophagy dysregulation was recently related to fibrosis. However, it is unclear whether (...)
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MO431: Estimation of the Risk of Progression and Renal Substitution Treatment in Patients With Chronic Kidney Disease Using an Artificial Intelligence Model - Isaza Ruget M, Yomayusa N, Gonzalez C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe use of tools that allow to estimate the probability of progression of chronic kidney disease (CKD) to advanced stages, has not yet gained a notable space in our clinical practice. The aim of this study was to develop and validate a model to predict disease (...)
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MO432: The ESRD Progression Delayed by Transplanting 3D Printed Omental Patch - Jo H, Choi B, Kim B, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRenal fibrosis is one of the pathological hallmarks of chronic kidney disease (CKD) that can further progress to end-stage renal diseases (ESRD). Haemodialysis and kidney transplantation are the only feasible treatments of ESRD. In this study, a new treatment with (...)
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MO299: Profile Of COVID-19 Patients who Developed Acute Kidney Injury in Intensive Care: Multicentre Study - Afifi R, Maazouzi C, Medkouri G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe SARS-COV-2 acute respiratory distress fyndrome, which is the source of the infection known as coronavirus disease (COVID-19), spread rapidly, causing a pandemic that not only severely affected human health but also restricted the activities of daily living and (...)
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MO309: Serum Sodium Trajectory During AKI and Mortality Risk - Chávez-Iñiguez J, Michell J, Luna-Ramos A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSKidneys play a primary role in electrolyte homeostasis. The association between serum sodium level and mortality or the need for kidney replacement therapy during acute kidney injury has not been adequately explored.METHODIn this prospective cohort study, we enrolled (...)
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MO296: Seasonal Variations in AKI Incidence and Outcomes - Alsahow A, Alkandari O, Alyousef A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSKuwait enjoys a cool winter but suffers a very hot summer. We aim to evaluate the relationship between weather temperature and acute kidney injury (AKI) incidence and outcome.METHODWe prospectively collected demographic (age, sex and nationality), clinical (CKD (...)
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MO308: Urinary Biomarkers to Predict Acute Kidney Damage and Mortality In COVID-19 - Racovitan D, Hogeweg M, Doevelaar A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AK) is a frequent condition in patients hospitalized for COVID-19. There are only few reports on the use of urinary biomarkers in COVID-19 and no data comparing the prognostic use of individual biomarkers in the prediction of adverse outcome so (...)
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MO326: Factors Influencing Death Rate in COVID-19-Associated Acute Kidney Injury - Daniela R, Cuiban E, Adela Vacaroiu I, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSDuring a 2-year pandemic, COVID-19 proved to be a condition with a high potential to affect various organs other than the lungs. Acute kidney injury (AKI) in hospitalized COVID-19 patients is associated with a poor prognosis. The aim of this study was to identify (...)
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MO340: Acute Kidney Disease in the Outpatient Setting: From Big Data Phenotyping to Biomarker Validation Using the NGAL and DNLITE-IVD103 Tests - Kuo C, Yeh H, Chiang H, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) and acute kidney disease (AKD), a typical inpatient disease spectrum, pose an exceptional burden on the current healthcare system worldwide. By contrast, developing operative diagnostic criteria for AKD in the outpatient setting (AKDOPT) (...)
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MO341: Clinical Significance of Post-Operative Acute Kidney Disease After Non-Cardiac Surgery - Kwon S, Yang S, Lee H. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney disease (AKD), the condition of which acute kidney injury (AKI) has not recovered, is being emphasized because it increases the risk of progression to chronic kidney disease (CKD). Post-operative AKI (PO-AKI) is a common clinical setting prone to develop (...)
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MO385: Performance of Creatinine-Based Equations to Estimate Glomerular Filtration Rate in White and Black Subjects From Europe, Brazil and Africa - Delanaye P, Bjork J, Vidal-Petiot E, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCurrent Glomerular filtration rate (GFR) estimating equations based on serum creatinine are facing increased criticism due to the inclusion of a race correction in black Americans with the CKD-EPI equation (CKD-EPIASR, A = Age, S = Sex, R = Race). A new equation (...)
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MO386: Visualising and Differentiating Kidney Disorders by Urinary Peptidomics Using a Machine Learning Approach - Siwy J, Mavrogeorgis E, He T, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCurrently >20 000 native peptides in urine are known that are highly dynamic and able to display the status of different organs, especially the kidney. The characterization of urinary peptide profiles (UPP) enables the depiction of kidney disease severity, (...)
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MO417: Obesity Associated With Vitamin D Deficiency Impairs Renal Function, Haemodynamics, Metabolic Parameters And Aggravates the Renal Morphological Damage in Rats Submitted To Ischaemia-Reperfusion Injury - Bernardo D, Carolina de Braganca A, Heloisa Massola Shimizu M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) alters renal haemodynamics, leads to tubular injury, activates pathways of inflammation, proliferation and cell death. The initial damage caused by ischaemia/reperfusion injury (IRI) plays an important role in the pathogenesis of the AKI and (...)
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MO418: The Risk of Renal Co-Morbidities in Celiac Disease Patients Depends on the Phenotype of Celiac Disease - Nurmi R, Pasternack C, Salmi T, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAlbeit the association between renal disorders and celiac disease is still somewhat contradictory, an elevated risk of kidney diseases in patients with celiac disease has been shown [1, 2, 3]. Only case reports have described the link between glomerulonephritis and (...)
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MO435: The Prognostic Implication of 24-h Urine Urea Excretion With Renal Progression: Analysis of KNOW-CKD Study - Cheol Jeong J, Oh K, Chae D. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSUrea excretion is the basic function of the nephron. However, its prognostic implication has been not extensively studied in a specific subpopulation of chronic kidney diseases (CKD).METHODTotal of 2232 patients in KNOW-CKD cohort were analyzed. Baseline (...)
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MO436: The Effect of Protein-Restriction on the Tubular Handling of the Uraemic Retention Solute Indoxyl Sulfate - Lauriola M, Dejongh S, Farré R, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) patients present an increased plasma level of protein-bound solutes known as uraemic toxins. Their accumulation is associated with, amongst others, cardiovascular events. The gut microbiome plays an important role in the generation of part (...)
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MO437: Decreased Urinary Citrate Levels as a Marker of Progressive Deterioration of Glomerular Filtration in Patients With Autosomic Dominant Polycystic Kidney Disease (ADPKD) - Borrego-Utiel F, Merino Garcia E, Herrera I, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIn a previous work we have found that there is a reduction in urinary citrate levels in autosomic dominant polycystic kidney disease (ADPKD) patients. Their levels are related to GFR but not serum bicarbonate levels. Our aim was to analyse whether there is any (...)
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MO438: Excessive Mitochondrial Copper Load Driven by Upregulated Copper Transporter 1 Contributes to Mitochondrial Dysfunction and Renal Fibrosis - Zhu S, Yu C. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCopper is an essential trace element for eukaryotes and a vital cofactor for various enzymes for a multiplicity of functions. Our previous study indicated that intracellular copper overload plays an important role in renal fibrosis. However, the underlying mechanism (...)
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MO471: Adverse Drug Reactions and Drug–Drug Interaction in Chronic Kidney Disease With Tuberculosis - Datta D, Attur Prabhu R, Abdul Khader N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe risk of developing tuberculosis (TB) is 10–25% in chronic kidney disease (CKD) patients. TB in CKD patients may have a mortality of 16–37%. Standard treatment with four drugs (Isoniazid, Rifampin, Pyrazinamide and Ethambutol) predisposes to side effects, drug (...)
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MO472: Comparison of the Quality of Life and Survival in Children Undergoing Hemodialysis Versus Peritoneal Dialysis: A Comparative Cross-Sectional Study - Mazighi S, Nabil H, Chettati M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSA child with end-stage renal disease (ESRD) hopes for a kidney transplant to avoid dialysis. Despite the recent priority rules for assigning transplants to children. Most of them, due to their young age, the time required to prepare for the transplant, and especially (...)
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MO473: Conservative Management in Hospitalized Patients With Advanced Chronic Kidney Disease—A Single Centre 4-Years’ Experience - Silva R, Figueiredo C, Romãozinho C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThere is an increasing number of patients with advanced chronic kidney disease (CKD) who are older, frail, with multi-morbidity, and with poor functional status. Renal palliative medicine or kidney supportive care is an evolving branch of nephrology. In medicine, (...)
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MO474: Expectation and Acceptance of a Clinical Decision Support Software by Nephrologist End-Users: The Ckdnapp Survey - Kinga Kotsis F, Beachle H, Altenbuchinger M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is a major public health problem. CKD constitutes a complex disease due to differing underlying disease etiologies in each patient, which can in turn lead to many complications, comorbidities and polypharmacy. Monitoring disease (...)
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MO491: Low Income is Associated With Late Nephrology Referral in Portugal: A Retrospective Study - Duarte R, Trigo A, Luz I, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSocial disparities in chronic kidney disease (CKD) are a reality. Low socioeconomic status is associated with an increased incidence of CKD and overall worse outcomes. In Portugal, similarly to many European countries, a National Health System (NHS) was established to (...)
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MO492: ‘The Disease Awareness Innovation Network’ (DANTE) Framework for Chronic Kidney Disease Diagnosis - Pesce F, Pasculli D, Pasculli G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe global burden of chronic kidney disease (CKD) is growing, impacting around 10% of the worldwide population becoming the 5th cause of mortality by 2023, with high cost for the health care system (Glassrock et al. 2017). CKD can be identified using two easy and (...)
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MO493: Covid-19 Among Romanian HAemodialysis Patients: Risk Factors and Outcomes. Data From the Romanian Renal Registry - Stefan G, Garneata L, Podgoreanu E, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSDuring the COVID-19 pandemic, patients on maintenance heamodialysis (HD) are vulnerable due to their comorbidities, uremia-impaired immunity and limited physical distancing. We aimed to evaluate the risk factors and outcomes of SARS-CoV-2 infection in HD patients in (...)
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MO494: The Prospective Roles of Urinary Dickkopf-3 for Detecting Renal Function Deterioration and Monitoring Chronic Kidney Disease Progression: Systematic Review of Cohort Studies - Pratama Putra B, Nugraha Putra F. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is a worldwide health problem whose incremental prevalence. Early detection and proper monitoring of renal dysfunction can decrease morbidity and mortality among CKD patients. Estimated glomerular filtration rate (eGFR) and albuminuria (...)
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MO298: Predictors of Renal Function Recovery in Critically ill Patients With Acute Kidney Injury - Knezevic V, Azasevac T, Petrovic L. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a frequent and serious complication in critically ill patients admitted in intensive care unit (ICU). The development of acute kidney damage is associated with various adverse outcomes, such as prolonged stay in the ICU, the development of (...)
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MO306: Pharmacologic versus Immunologic Acute Interstitial Nephritis Long Term Outcome. Are There any Differences - Arana C, Marco Rusiñol H, Arce Y, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute interstitial nephritis (AIN) is a common cause of acute renal failure affecting between 5% and 27%. It is characterized by the presence of interstitial inflammatory infiltrate, tubulitis and edema. A considerable number of cases develop chronic kidney disease (...)
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MO316: Eculizumab for Adult Patients With Atypical Haemolytic-Uremic Syndrome: Full Dataset Analysis of Post-Marketing Surveillance in Japan - Maruyama S, Ikeda Y, Kaname S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAtypical haemolytic uremic syndrome (aHUS) is a form of thrombotic microangiopathy (TMA) associated with dysregulation of the alternative complement pathway [1]. It is characterized by microangiopathic haemolytic anaemia, thrombocytopenia and acute kidney injury [1]. (...)
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MO323: Effects of Patient Frailty and Comorbidity on Duration of Hospitalisation as an Outcome Among Adults With Acute Kidney Injury - Lobo A, Waters C, Aspin N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is commonly associated with an adverse outcome in hospitalised patients. Frailty and comorbidity are risk factors for acute kidney injury. The aim of this study was to assess the strength of association between frailty and comorbidity as (...)
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MO324: Serum Potassium Trajectory During AKI and Mortality Risk - Chávez-Iñiguez J, Aranda-G de Quevedo A, Chávez-Alonso G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSKidneys play a primary role in potassium homeostasis. The association between potassium (sK+) level and mortality or the need for kidney replacement therapy (KRT) during acute kidney injury (AKI) has not been adequately explored.METHODIn this prospective cohort study, (...)
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MO344: Effect of Cancer Stage on Adverse Kidney Outcomes in Patients With Advanced Melanoma Treated With Immune Checkpoint Inhibitors - Wang Q, Strohbehn I, Strohbehn S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSImmune checkpoint inhibitor (ICI) therapy has improved the outcome of advanced melanoma but can also lead to kidney injury. Anti-programmed cell death protein 1 (anti-PD-1) therapy is now used in adjuvant setting for stage 3 melanoma after curative intent surgery, and (...)
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MO345: Clinical Characteristics and Trajectory in a National Cohort of Veterans Treated With Conservative Management Versus Dialysis - Narasaki Y, Rhee C, You A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSWithin the Veterans Health Administration, the largest integrated healthcare system in the USA, 1.1 million Veterans (16.4%) have been identified as having chronic kidney disease (CKD). Annual spending on US Veterans with non-dialysis dependent CKD is estimated at $19 (...)
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MO295: Acute Kidney Injury in COVID-19 Patients: Medium-Term Evolution of Renal Function - Almenara Tejederas M, Burgos Martin J, Valverde Ortiz R, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a common complication among patients hospitalized with COVID-19. The incidence of AKI is estimated to be around 5%–80%, according to the series, but data on renal function evolution is limited. Our main objective was to describe the (...)
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MO305: COVID-19 in Elderly Patients with Acute Kidney Injury - Ayar Y, Deniz O, Doner B, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCoronavirus disease 2019 (COVID-19), which started in China in December 2019 and spread all over the world, is more progressive in patients who are elderly and with chronic diseases. Especially, kidney involvement affects the survival of patients. In this study, we (...)
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MO313: Haematological Ratios as Risk Factor for Acute Kidney Injury in Patients Suspected of an Infection at the Emergency Department - de Hond T, Khairoun M, Haitjema S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSEvidence exists that inflammation plays an important role in the pathogenesis of acute kidney injury (AKI) in sepsis patients. Haematological ratios can be used to measure systemic and silent inflammation. Therefore, we investigated what haematological ratios could be (...)
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MO297: Acute Kidney Injury Among COVID-19 Positive Patients is Associated With Higher Mortality: Single Center Experience - Ashry Ahmed Gheith O, Maher Nagib A, Elserwy N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSDespite the lungs are the major targets of COVID-19, other organs such as the kidneys are also affected. Renal complications of COVID-19 are not yet well studied. We aimed to study the prevalence of acute kidney injury (AKI) among positive COVID-19 cases that were (...)
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MO304: Severe Sars-COV-2 Infection in Patients with Chronic Kidney Disease and Lung Disease. Outcomes and Referral for Palliative Care in a Tertiary Center in SÃo Paulo, Brazil - Sandoval Terra Campos Guelli M, Zampier D, Pinto Monezzi P, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCoronavirus disease 2019 (COVID-19) is mainly an infectious disease of the respiratory system transmitted through air droplets, and pulmonary symptoms constitute the main presentations of this disease [1]. The first cases of the disease were identified in Wuhan, (...)
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MO312: Long-Term Kidney Function Outcome After COVID-19 Associated Acute Kidney Injury and Kidney Replacement Therapy in Intensive Care - Smolander J, Rashid Tony Qureshi A, Bruchfeld A. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI), frequently with concurrent albuminuria and haematuria, is common and increases mortality in COVID-19 infection. We present the clinical course and long-term outcomes of COVID-19 survivors with AKI and continuous kidney replacement therapy (...)
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MO293: Evaluation of Uric Acid Concentration and Acute Renal Impairment in Patients on Admission for Hospital Treatment - Tasic D, Dimitrijevic Z, Radenkovic S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSElevated uric acid (UA) is associated with comorbidities such as hypertension, diabetes, cardiovascular disease and chronic kidney disease. There are more studies that discuss the importance of uric acid (UA) for acute kidney failure. Anaemia is a common risk factor (...)
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MO303: Impact of Dexamethasone and Inhaled Nitric Oxide on Severe Acute Kidney Injury in Critically ill Patients With COVID-19 - Bobot M, Tonon D, Peres N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSKidney failure is the second most frequent condition after acute respiratory distress syndrome (ARDS) in critically ill patients with severe COVID-19 and is strongly associated with mortality. The aim of this multicentric study was to assess the impact of the specific (...)
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MO318: Utility of D-Dimer Levels in Predicting the Renal Outcome of Acute Kidney Injury in Moderate and Severe COVID-19: A Retrospective Study - Daniela R, Onofrei S, Adela Vacaroiu I, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a potential complication of COVID-19 and the hypercoagulation tendency of SARS-CoV-2 infection is considered one of the underlying mechanisms. Fibrinolysis markers have been described as severity parameters, independent of clinically (...)
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MO327: Acute Kidney Injury in Post Liver Transplantation in a Hospital in BogotÁ, Colombia - Molano-Triviño A, Martínez C, Saumett S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSLiver transplantation is a mandatory treatment for many cirrhotic patients worldwide. Nonetheless, frequently there is high systemic morbidity and considerable mortality in post transplantation [1].Our aim was to calculate acute kidney injury incidence (KDIGO), need (...)
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MO328: Acute Renal Failure in COVID-19: Aetiology and Renal Evolution. AKI-COVID Registry of the Spanish Society of Nephrology - Almenara Tejederas M, Luisa Serrano Salazar M, Rosa Melero Martin M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) has been described as a frequent complication in patients with COVID-19. The incidence of AKI is estimated to be around 5%–80% depending on the series; however, data characterizing the type of AKI and the evolution of renal function parameters (...)
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MO381: Estimating GFR in Renal Transplanted Patients With Equations Based on Creatinine (With or Without Race Variable) and/or Cystatin C - Delanaye P, Masson I, Maillard N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCurrent Glomerular filtration rate (GFR) estimating equations based on serum creatinine are facing increased criticism due to the inclusion of a race correction in black Americans with the CKD-EPI equation (CKD-EPIASR, A = Age, S = Sex, R = Race). New equations (...)
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MO382: Validation of a Handheld Point-Of-Care Creatinine/EGFR Meter for Evaluating Renal Function - Begos D, Milojkovic B. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMeasurement of glomerular filtration rate (GFR) is a cumbersome, time consuming, and expensive process, thus estimated GFR (eGFR) has become a commonly accepted surrogate or screening tool for individuals suspected to have kidney disease. Until recently this required (...)
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MO399: Remodel: A Mechanistic Trial Evaluating the Effects of Semaglutide on the Kidneys In People With Type 2 Diabetes and Chronic Kidney Disease - Bjornstad P, Cherney D, Lawson J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSApproximately 40% of people with type 2 diabetes (T2D) develop chronic kidney disease (CKD) and, despite current treatment, T2D is the most common cause of progression to kidney failure. This situation underscores the need for additional pharmacotherapeutic options. (...)
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MO400: Treatment of Renal Artery Stenosis: Nephrology, the Best Surgery - Pérez Fernández Á, García Pablos N, Salcedo Herrero D, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRenal artery stenosis causes hypertension in 10–40% of severe cases or refractory to treatment. As a gold standard test for its diagnosis, we have arteriography, which allows the interventional therapeutic option, through angioplasty and/or stenting. There is no (...)
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MO419: Many Faces of Non-Proteinuric CKD—A Cluster-Analysis-Based Observation - Tanaka H. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSWith a global expansion of the elderly population, physicians encounter a growing number of chronic kidney disease (CKD) patients who have no or only a minimal amount of proteinuria. However, those patients are not clinically uniform; some quickly develop into a (...)
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MO420: Effects of Indoxyl Sulfate and Apixaban in Liver Gene Expression - Pina Beltrán B, Poitevin S, Giot M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSUraemic toxins accumulate in the blood and tissues of patients with chronic kidney disease (CKD). Previous animal studies have shown that chronic kidney disease (CKD) not only alters the elimination of drugs excreted by the kidneys, but it also impacts the metabolism (...)
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MO294: Multidisciplinary Management of Obstructive Anuria: Uro-Nephrological Interdependence of the Patient Service - Afifi R, Alafifi M, Zamd M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSObstructive anuria is defined as a total cessation of diuresis or a volume of METHODFrom January 2018 to December 2020, we conducted a 3-year retrospective and descriptive study of patients treated at the CHU IBN ROCHD of Casablanca's nephrology and haemodialysis (...)
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MO302: The Correlation Between Serum and Urinary NGAL With Redox Biomarkers in Post-Ultramarathon Amateur Athletes - César Carneiro Loureiro A, Fontenele Nocrato G, Luis Lima Correia A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSFew studies have investigated the physiological alterations provoked by ultramarathon competition, particularly those related to redox balance, kidney function and NGAL regulation. A better understanding of the dynamics of these biomarkers during ultramarathons could (...)
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MO310: Clinical Characteristics and Outcomes of Acute Kidney Injury in Hospitalized Patients With COVID-19: Experience at a Major Tertiary Care Center in Pakistan - Yaqub S, Hamid A, Saeed M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSLimited data exists on acute kidney injury (AKI) in patients hospitalized with COVID-19, its risk factors and associated outcomes from low-middle income countries. We aimed to determine the epidemiology of AKI and its impact on outcomes at a tertiary-care center in (...)
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MO321: The Critical Role of Cytokine Dysregulation in Acute Kidney Injury Development in Patients With COVID-19 - Moreno-Amaral A, Soares Tozoni S, de Castro Deus M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSOne of the complications described in critically ill patients in intensive care units with severe COVID-19 was acute kidney injury (AKI). The pathophysiology of AKI in patients with COVID-19 is multifactorial. In addition to the direct virulence of SARS-CoV-2 in renal (...)
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MO322: Utility of Contrast-Enhanced Ultrasound to Predict Renal Recovery in Patients With Sepsis-Associated Acute Kidney Injury Receiving Renal Replacement Therapy - Cho H, Yun Lee H, Shin J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMicrocirculation plays a critical role in the development of sepsis-associated acute kidney injury (S-AKI); however, it remains uncertain whether microcirculatory dysfunction influences recovery. We investigated the association of contrast-enhanced ultrasound (...)
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MO342: Impact of COVID-19 Pandemic on In-Hospital Acute Kidney Injury Epidemiology and Outcomes: A Retrospective Cohort Study - Esposito P, Russo E, Picciotto D, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a common complication in patients affected by coronavirus disease-19 (COVID-19) and its development is associated with high mortality [1]. However, it is also clear that the COVID-19 pandemic has effects on the management of diseases not (...)
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MO343: Deep Analysis of The AKI—CKD in Allogeneic Stem Cell Transplantation—A Big Data Approach - Brüder N, Kielstein J, Heinze L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a common complication in allogeneic stem cell transplantation (SCT). Although short-lived, i.e. < 90 days, in the majority of patients renal injury can persist for more than 3 months fulfilling the criteria of chronic kidney disease (...)
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MO383: Structural Equation Modelling to Improve Kidney Function Assessment in The General Population - Fujii R, Barbieri G, Ghasemi D, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIn order to identify behavioral, environmental, biological or genetic determinants of kidney function, population-based epidemiological studies rely on approximate estimates of the glomerular filtration rate (eGFR) based on measured markers such as serum creatinine, (...)
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MO384: Identifying Long Non-Coding RNA Biomarkers From Urinary Exosomes for Diabetic Nephropathy - Zhu X, Feng S, Jing J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSDiabetic nephropathy (DN) is the common cause of end-stage renal disease. However, the early and specific diagnostic biomarkers are still lacking. Urinary exosomes are a potential source of biomarkers for kidney disease due to their renal cell origination, stability, (...)
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MO409: GDF-15 is a Predictor of Mortality in Chronic Kidney Disease Patients With Covid-19 Infection - Ciceri P, Bono V, Magagnoli L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSA cytokine storm drives the pathogenesis of severe coronavirus disease (COVID-19) and several biomarkers with different mechanisms of action have been linked to mortality. Chronic kidney disease (CKD) emerged as a very common risk factor for severe COVID-19. Indeed, (...)
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MO291: Comparison of Acute Kidney Failure in Patients With SARS-COV-2 Infection During the First and Second Waves in a Third-Level Hospital in Andalusia - Cintra M, Burgos Martin J, Almenara Tejederas M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe incidence of acute renal failure (ARF) is frequent and has an implication in the morbidity and mortality of SARS-CoV-2 infection.METHODA retrospective descriptive study of patients admitted for SARS-CoV-2 infection during the first (G1) and second (G2) waves who (...)
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MO301: The Incremental Chronic Kidney Disease Risk Among Post-Hospitalized Leptospirosis Patients With Acute Kidney Injury: Systematic Review And Meta-Analysis - Pratama Putra B, Nugraha Putra F. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSLeptospirosis is a global zoonotic bacterial disease that may cause life-threatening complications, such as acute kidney injury (AKI). Patients with AKI may recover fully, but some can progress to chronic kidney disease (CKD) or even become dialysis-dependent. This (...)
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MO307: Prognostic Value of Sea-Make Score in Predicting Major Adverse Kidney Events Among Adult Filipino Patients With Acute Kidney Injury - Ang V, Marie Luy T, Leano J. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a prevalent complication among hospitalized patients worldwide and is associated with a high morbidity and mortality rate. The SEA-MAKE score is a scoring tool recently introduced to predict major adverse kidney events (MAKE), defined as (...)
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MO314: Oliguria as a Strong Predictor of Mortality in Leptospirosis - Rista E, Cadri V, Saliaj K, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSLeptospirosis is an endemic, globally widespread zoonotic disease caused by pathogenic spirochetes of the genus Leptospira. It presents with high clinical variability, with a constellation of symptoms ranging from a mild, nonspecific, self-limiting febrile syndrome to (...)
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MO315: Risk Factors for CSA-AKI and Performance of Leicester Score in a Spanish Cohort - Molina Andujar A, Joaquin Escudero V, Blasco M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe incidence of acute kidney injury following cardiac surgery (CSA-AKI) is up to 30% and it places patients at an increased risk of death. Leicester score (LS) is a new score designed by Birnie et al. [1] and validated in 2014 in a British Cohort. It predicts CSA-AKI (...)
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MO332: Acute Kidney Injury is Associated With Poor Long-Term Outcomes in Hospitalized Patients With COVID-19 - Khruleva Y, Efremovtseva M, Kobalava Z. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe acute effects of the acute kidney injury (AKI) on short-term mortality in patients with novel coronavirus infection (COVID-19) have been studied, but the long-term outcomes after COVID-19-associated AKI are not well understood. Our aim was to evaluate the impact (...)
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MO333: Prevalence of COVID-Associated Renal Injury in ICU and Prognosis of Proximal Tubular Dysfunction in Acute Respiratory Distress Syndrome - Bobot M, Heim X, Max H, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSDuring COVID-19, the renal impairment is the most frequent after lung impairment and is associated of poor prognosis particularly in the intensive care unit (ICU). In this work, we aim to assess the incidence of acute kidney injury (AKI) in COVID-19-related acute (...)
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MO373: How to Decide Whether Creatinine or Cystatin C is More Accurate for Kidney Function Assessment in Older Adults - Potok A, Rifkin D, IX J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe gold standard for evaluation of kidney function is measured GFR [mGFR] which is challenging to perform in clinical practice. Serum creatinine and cystatin C are used to estimate GFR clinically, but neither is a perfect marker. Within any given individual, the (...)
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MO374: Urinary Cell Transcriptomics Provides a Non-Invasive Readout of Kidney Genes Essential to Renal Health and Disease - Eales J, Bogdanski P, Wystrychowski W, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease affects up to 15% of adults, current diagnostic methods for assessing kidney health and early detection of renal disease lack sensitivity and/or can be highly invasive. The kidney sheds cells into the urine and harvesting these cells and their (...)
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MO389: Klotho Supplementation Reverses Renal Dysfunction and Interstitial Fibrosis in Remnant Kidney - Takenaka T. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSeveral studies demonstrate that klotho shows renoprotective actions. However, it has not been assessed whether klotho supplementation is able to reverse the renal injury.METHODIn the present study, the effects of klotho protein supplementation on remnant rat kidneys (...)
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MO390: Prognosis of Kidney Damage Associated With Tobacco Consumption in Former Smokers - Tascón J, G. Casanova A, Vicente-Vicente L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSTobacco is a risk factor for some cardiovascular and respiratory diseases, as well as for the development of some tumours. Furthermore, new research has shown evidence of the risk that smokers have of developing kidney disease [1]. On the other hand, biomarkers used (...)
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MO391: Association Between Skeletal Muscle and Level of Physical Activity in Patients With Chronic Kidney Disease: A Cross-Sectional Analysis of the Peaking Cohort - Xiao C, Zeng J, Yang C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSFavorable skeletal muscles have been associated with higher physical activity (PA) in the general population. However, little is known regarding this relationship in a population of Chinese chronic kidney disease (CKD) patients. The aim of this study is to investigate (...)
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MO411: SGLT2 Inhibitors Use in Chronic Kidney Disease-Better Cardiometabolic Profile - Ivandic E, Jelakovic A, Jelakovic B, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSGLT2 inhibitors have been shown to reduce kidney and cardiovascular events and slowing the decline of renal function in chronic kidney disease. We have examined the effect of SGLT2 inhibition in our cohort of ambulatory patientsMETHODWe have included patients with (...)
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MO412: Impact of Body Mass Index on Mortality and End–Stage Kidney Disease in Patients With Non-Dialysis Dependent Chronic Kidney Disease - Al-Chalabi S, Nawaz S, Lodge M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSObesity is a major global problem affecting more than 1.9 billion adults [1]. The aetiological factors of obesity are complex and consist of genetic, social and environmental elements. Obesity can lead to chronic kidney disease (CKD) via both direct and indirect (...)
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MO447: Glomerular Transcriptomics in IGA Nephropathy Differentiates Between Disease Progression and Stability in Low-Risk Patients After Prolonged Follow-Up - Rivedal M, Mikkelsen H, Knoop T, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. We have previously shown that patients with assumed benign IgAN can develop progressive kidney failure, including end-stage kidney disease, after a sufficiently long follow-up period [1]. (...)
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MO448: Progressive Tubular Injury Caused by High Phosphate Intake is Associated With Activation of STAT3/KIM-1 Signalling and Macrophage Recruitment in Mice - Richter B, Kapanadze T, Weingärtner N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSDietary phosphate intake greatly exceeds the recommended daily allowance in the Western population. Elevated phosphate levels are linked to increased cardiovascular and all-cause mortality, impaired bone health and premature ageing. The renal effects of chronic high (...)
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MO449: Polycystins are Upregulated in Fibrotic Kidneys and Promote Renal Fibrosis - Wang Y, Wu M, Ye C. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMutations in PKD1 or PKD2 gene, which encodes polycystin-1 or polycystin-2, cause autosomal polycystic kidney disease (ADPKD). The development of ADPKD is associated with the progression of renal fibrosis. Whether renal fibrosis in ADPKD is a direct effect of PKD (...)
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MO450: A New Hematuria Score, Semi-Quantitative Analysis of Hematuria Normalized for Urine Concentration Predicts the Progression of Chronic Kidney Disease: From the KNOW-CKD Study - Koh J, Min Jo S, Kim S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIt is unclear whether hematuria is a risk factor for chronic kidney disease (CKD) progression. In addition, quantitative evaluation considering urine concentration as in proteinuria has not been established in hematuria. The aim of this study is to verify the (...)
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MO479: CKD Coding Across Hertfordshire and West Essex. Are We Missing the Chance for Early Intervention? - Findlay A, Sivaramakrishnan R, Hanna A. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCoding of chronic kidney disease (CKD) is associated with better outcomes through addressing the risk factors, and CKD-coded cases were found to have fewer unplanned hospital admission rates.We aim to compare the CKD coding across Hertfordshire and West Essex to the (...)
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MO480: Predictive Ability of Clinical Assessment Tools For >2 Weeks in-Hospital Stay Following Hip Fracture in Patients Living With CKD: Insights From a 7-Year Prospective Analysis - Lin Henry Wu H, Van Mierlo R, Mclauchlan G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIndividuals living with chronic kidney disease (CKD) are at greater risk of sustaining hip fractures compared with the general population. Following acute trauma, CKD patients are susceptible to lengthened hospitalization with their clinical condition exacerbated by (...)
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MO481: Novel Predictors of CKD in Metabolic Fatty Liver Disease Patients: Steatosis Vs Fibrosis. A Prospective Study Using Transient Elastography With Controlled Attenuation Parameter - Marc L, Mihaescu A, Lupusoru R, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRecent data have proven that NAFLD (nonalcoholic fatty liver disease) and NASH (nonalcoholic steatohepatitis) increase the risk of CKD. Changing the concept of NAFLD to MAFLD (metabolic dysfunction associated fatty liver disease) changes the data of inclusion of (...)
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MO482: End-Stage Renal Disease in the Elderly: Dialysis or Conservative Management? - Denden G, Ben Mahmoud N, Ben Salem M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSNowadays, end-stage renal disease (ESRD) is overrepresented in elderly patients. The presence of medical comorbidities, limited life expectancy, frailty and poor functional status in these patients poses substantial challenges in clinical decision-making and provision (...)
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MO495: A Comparative Study of Patient Mortality During First and Second Waves of Covid-19 Pandemic in Dialysis Patients and Kidney Transplant Recipients - Vart P, Jager K, Arnol M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPatients on kidney replacement therapy (KRT) are at a particularly high risk of mortality from COVID-19. In this study, we investigated COVID-19 mortality in KRT patients in the first and second waves of the pandemic and potential reasons for any difference in (...)
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MO496: Serum Urea Levels and Cardiovascular Disease in Patients With Chronic Kidney Disease - Laville S, Couturier A, Lambert O, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSElevated serum urea levels are common in moderate-to-advanced CKD. Several studies have shown that urea is a direct and indirect uremic toxin, especially with regard to cardiovascular disease. We sought to determine whether serum urea levels are associated with (...)
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MO497: Upper Tract Urothelial Cancer and Balkan Endemic Nephropathy: 65 Years of Follow UP - Glogovac S, Tasic D, Dimitrijevic Z, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAll researchers dealing with Balkan endemic nephropathy (BEN) talk about the association of BEN with malignant tumours of the upper urothelium (UTUC). Long-term research of UTUC obtained various results depending on the period and region of observation, depending on (...)
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MO498: Incident Chronic Kidney Disease in Older Adults With Diabetes - Lim C, Mong Bee Y, Ang A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is a growing global public health burden among aging populations and is associated with increased risks of cardiovascular disease, kidney failure and death. Early identification and treatment can amelioriate these risks. We aimed to (...)
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MO499: Incidence of Cause-Specific Cardiovascular Events in Men and Women With CKD - Faucon A, Lambert O, Alencar de Pinho N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMen are at higher risk of cardiovascular disease (CVD) than women in the general population, and chronic kidney disease (CKD) is a well-established cardiovascular (CV) risk factor [1–4]. However, the incidence of cause-specific CV events in men and women with CKD is (...)
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MO500: Increased Mortality and Readmission Rates Among Hospitalized Covid-19 Patients With Varying Stages of Chronic Kidney Disease - Appelman B, Oppelaar M, Broeders L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) has been recognized as a highly prevalent risk factor for both the severity of coronavirus disease 2019 (COVID-19) and COVID-19 associated adverse outcomes. In this multicentre observational cohort study, we aim to determine the mortality (...)
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MO501: A Nomogram Based on Heart Rate Variability Parameters for Predicting All-Cause Mortality in Stage 5 CKD Patients - Gao X, Wang J, Huang H, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSHeart rate variability (HRV), reflecting the circadian rhythm of heart rate, is associated with clinical outcomes in stage 5 chronic kidney disease 5 (CKD5) patients. Whether CKD-related factors combined with HRV can improve the predictive ability for their death (...)
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MO502: Use of Lithium, Valproate and the Risk of Acute or Chronic Kidney Disease: An Observational Study From Routine Care Data - Bosi A, Laura C, Fu E, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSLithium is an established treatment for bipolar disorder and treatment-resistant depression. Despite awareness of potential kidney damage, there is a lack of research evidence to inform on the existence and magnitude of the risk. Observational studies to date show (...)
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MO401: Low Glomerular Density, a Risk Factor for Progression of Extra-Membranous Nephropathy - Ajimi K, Ben Salem M, Hammouda M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSBefore the onset of renal failure in idiopathic membranous nephropathy (MN), the role of certain histological factors in the progressive loss of renal function are still poorly understood. The present study examined the relationship between glomerular density (GD: (...)
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MO402: Symmetric Dimethylarginine Inhibits Renal Fibrosis in Obstructive Kidneys - Wang Y, Wu M, Ye C. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSymmetric dimethylarginine (SDMA) is regarded as an independent cardiovascular risk factor in patients with chronic kidney diseases. Renal interstitial fibrosis is a common pathway of all kinds of chronic kidney diseases progressing to the end-stage of renal diseases. (...)
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MO451: The Usefulness of Calcium/Magnesium Ratio in the Risk Stratification of Early Onset of Renal Replacement Therapy - Afonso R, Calças Marques R, Borges H, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRecently, a growing number of studies have reported a close relationship between high serum calcium and low serum magnesium with vascular calcification. Endothelial dysfunction and vascular inflammation seem plausible risk factors for enhanced progression of kidney (...)
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MO452: The Protecting Role of Renin-Angiotensin System Inhibitors on Renal Function and All-Cause Mortality in Patients With Heart Failure Supported by Left Ventricular Assist Devices: Analysis From the Intermacs Registry - Lombardi G, Gambaro A, Manuel Ferraro P, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSHeart failure (HF) is a clinical problem highly prevalent in the general population (1–2%) and much more so among patients with chronic kidney disease (CKD) (17–21%). The left ventricular assist device (LVAD) is a type of mechanical circulatory support device (MCSD) (...)
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MO453: Post-Translational Guanidinylation of Apolipoprotein C3 (APOC3) is Associated With Kidney and Vascular Injury - Schunk S, Jankowski J, Fliser D, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCardiovascular diseases (CVD) and chronic kidney diseases (CKD) are highly prevalent in Western populations and account for a substantial proportion of mortality. We recently found that apolipoprotein C-3 (ApoC3), a constituent of triglyceride-rich lipoproteins, (...)
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MO454: Increased Senescent Cell Burden and Alterations in NRF2 Pathway Drive Uraemic Vascular Calcification in Humans - Hobson S, Laget J, Muyor K, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSVascular calcification is a clinical sequelae of chronic kidney disease (CKD) that is associated with high cardiovascular-related mortality in end-stage kidney failure (ESKF) patients. Increased senescent cell burden and dysregulation of the NRF2 pathway, the master (...)
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MO393: Increase Echogenicity and Kidney Length are Surrogate Markers of Kidney Function With an Increased Echogenic Pattern Being Most Predictive of Kidney Dysfunction in Hiv Patients in Kwazulu-Natal, South Africa - Frank A, Assounga A. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSNon-communicable diseases (NCDs) are rapidly emerging as a major cause of chronic kidney disease (CKD) in Africa with a reported prevalence of 10.7% locally. At current, few high-quality studies assessing the epidemiology of CKD in South Africa have been published. (...)
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MO394: Health Related Quality of Life in Patients With End-Stage Renal Disease Before and After Starting Dialysis During Pandemic Covid-19 - Pana C, Tuta L. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPatients with end-stage renal disease (ESRD) have complex functional and social changes that affect their quality of life (QoL), leading to an increased cardiovascular risk, mortality and overall morbidity. Several studies showed that general QoL worsened after (...)
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MO413: Registration of Image Modalities for Analyses of Tissue Samples Using 3D Image Modelling - Hermann J, Jankowski V, Jankowski J. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSBiopsies are a diagnostic tool for the diagnosis of histopathological, molecular biological, proteomic and imaging data, to narrow down disease patterns or identify diseases. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) provides an (...)
02:00
MO414: Sucroferric Oxyhydroxide (Velphoro®) Treatment Mitigates the Signs of Ageing-Related Sarcopaenia in Old Mice - Alcalde-Estévez E, Asenjo-Bueno A, Sosa P, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSarcopaenia, defined as the loss of muscle mass and function, is an ageing-related pathology associated with some important diseases such as chronic kidney disease (CKD). Hyperphosphatemia has been associated with both, ageing and CKD. Old mice show an increase in (...)
02:00
MO415: Kidney Expression of Canonical WNT Inhibitors and ?-Catenin in Experimental Models of Arterial Hypertension and Nephrectomy Induced CKD - Bogdanova E, Beresneva O. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe canonical Wnt (cWnt) is known to be involved in tubular recovery after kidney injury and fibrosis, while arterial hypertension (AH) promotes cWnt activity. The aim of the study was to investigate the kidney expression of ?-catenin and cWnt inhibitors in AH and (...)
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MO416: Predicting Serum Bicarbonate in Non-Dialysis Dependent CKD Patients - De la Torre-Quiroga A, S. Chávez-Iñiguez J, Raimann J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMetabolic acidosis (HCO3 < 22 mmol/L) is associated with an increased hazard of death in patients with chronic kidney disease (CKD) [1, 2]. It is further associated with muscle wasting, bone disease, hypoalbuminemia, increased inflammation, protein malnutrition, (...)
02:00
MO467: Time to Improvement of Itch Intensity in Patients With Chronic Kidney Disease-Associated Pruritus Treated With Difelikefalin - Csiky B, Walpen S, Schaufler T, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease-associated pruritus (CKD-aP) is frequently reported by patients with CKD undergoing haemodialysis (HD), impacting sleep quality, quality of life and depression. Difelikefalin is a selective kappa-opioid receptor agonist approved in the United (...)
02:00
MO468: Moving More Associates With Reduced Risk of Cardiovascular Disease and Death Across All Stages of Chronic Kidney Disease: A UK Biobank Study - Stevens K, Delles C, Mark P, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPhysical activity (PA) is widely recommended for the prevention of chronic conditions including cardiovascular (CV) disease. In chronic kidney disease (CKD), it is unclear whether PA confers a similar benefit. We examined whether the duration and intensity of PA are (...)
02:00
MO469: GPR124—A Driver of Fibrotic Kidney Diseases - Blank P, Schmidt A, Gehrmann W, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRenal fibrosis is a central feature of chronic kidney disease (CKD), and the severity of CKD correlates with the magnitude of renal fibrosis. Despite the causative role attributed to fibrosis in CKD progression, there is still no treatment available that directly (...)
02:00
MO470: Outcomes of Patients in Advanced Chronic Kidney Disease (ACKD) Consultation With Covid-19 Infection - Carlos Herrero Berron J, Suso A, Mon C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe coronavirus disease 2019 (COVID-19) has affected our patients not only in renal replacement therapy (RRT), but also in advanced chronic kidney disease (ACKD) consultation. Our aim is to assess the impact of COVID-19 in a group of patients of our ACKD (...)
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MO371: Should We Systematically Look for Urine Alterations in all Patients With Monoclonal Gammopathy of Undetermined Significance? - Iturralde Ros M, Maiztegi Azpitarte A, Ortiz Espejo M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMonoclonal gammopathy of undetermined significance (MGUS) has a high prevalence in the elderly population, being as high as 9% in subjects over 85 years. Population aging leads to an increase in the number of patients with MGUS. In 2012, monoclonal gammopathy of renal (...)
02:00
MO372: Concordance Between 24-H Proteinuria and Spot Urine Protein-Creatinine Ratio in the Evaluation of Patients With Glomerular Diseases - Shabaka A, Díaz Enamorado Y, Maria Cases Corona C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIt has been postulated that the protein-creatinine ratio in spot urine sample (uPCR) could be an adequate alternative to measurement of proteinuria in 24-h urine samples (24-h proteinuria), which despite being the gold standard for the diagnosis and follow-up of (...)
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MO368: Study of Relationship Between Some Biomarkers of Inflammation and Microbiomal Status in Patients With Chronic Kidney Disease - Olimkhonova K. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIn view of the fact that the human microbiota varies depending on many factors, including comorbid pathology, it seems reasonable to investigate the intestinal microbiota in patients with chronic kidney disease and its likely relationship with markers of systemic (...)
02:00
MO375: The Health Economic Impact of Accurately Diagnosing CKD With and Without a UACR Test at Different Points in the Pathway of Disease Progression - Mernagh P, Folkerts K, Garreta Rufas A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIn the Kidney Disease Improving Global (KDIGO) guidelines, it is recommended that an accurate chronic kidney disease (CKD) diagnosis is based on repeated positive test results for estimated glomerular filtration rate (eGFR) and urine albumin-to-creatine ratio (UACR). (...)
02:00
MO376: Can the Urinary Albumin-Creatinine Ratio Be Calculated Over the Urinary Protein-Creatinine Ratio in Chronic Kidney Disease? - Özgen E, Karali Korkmaz C, Y?lmaz M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSUrine albumin-to-creatinine ratio (ACR) and protein-to-creatinine ratio (PCR) are used to measure urine protein. Recent guidelines recommend the use of the ACR, and equations have been developed incorporating ACR to predict risk of kidney failure. Where ACR cannot be (...)
02:00
MO387: Dapagliflozin and Kidney Outcomes in CKD Patients with and without Type 2 Diabetes: Real Life Data (Precursor Announcement) - Griveas I. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSGlobally, diabetes mellitus is a leading cause of kidney disease, with a critical % of patients approaching end-stage kidney disease. At the same time, chronic kidney disease (CKD) is a major contributor to illness and is associated with impaired quality of life. (...)
02:00
MO388: A Critical Evaluation of Anthropological, Biological and Geo-Environmental Factors on Chronic Kidney Disease of unknown Aetiology in Affected Area Against Unaffected Area - Hewapathiranage S, Nayanamali A, Nanayakkara N. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease of unknown etiology (CKDu) has been a critical health issue among the farming communities of Sri Lanka for decades [1]. However, the distribution of CKDu in Sri Lanka is geographically significant by representing endemicity on its own [2]. This (...)
02:00
MO405: Leucine-Rich Alpha-2-Glycoprotein as a Potential Marker of Mesangial Cell Proliferation in Immunoglobulin a Nephropathy - Popova A, R?cenis K, Kuzema V, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSLeucine-rich alpha-2-glycoprotein (LRG1) is a novel proangiogenic factor involved in the abnormal angiogenesis and renal fibrosis in diabetic nephropathy by potentiating endothelial transforming growth factor-beta/activin receptor-like kinase 1 (TGF-?/ALK1) signalling (...)
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MO406: Evolution of Kidney Damage Associated With Tobacco Consumption - Tascón J, G. Casanova A, Vicente-Vicente L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSTobacco consumption is associated with cancer, cardiovascular and respiratory diseases. Although new research relates tobacco use with the development of kidney damage, classic biomarkers, such as plasma creatinine, are not useful to detect this kidney injury [1]. In (...)
02:00
MO439: Cardiovascular Mortality Among Persons With Advanced Chronic Kidney Disease: A Matched Cohort Study - Kofod D, Carlson N, Linnea Freese Ballegaard E, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) and diabetes are both well-established risk factors for cardiovascular mortality. However, the risk of cardiovascular mortality and the impact of diabetes for those who have already reached advanced CKD are poorly examined. We examined the (...)
02:00
MO440: Intramyocardial Artery Fibrosis and Media Hypertrophy are Associated With Beta-Catenin and Calcineurin Expression in the Model of Arterial Hypertension and CKD - Bogdanova E, Beresneva O, Ivanova G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIntramyocardial arteries (IA) are one of the components of pathological cardiac remodeling. We have previously shown that cardiomyocytes hypertrophy and interstitial fibrosis are accompanied by calcineurin (CaN) and ?-catenin (?Cat) up-regulation in the model of (...)
02:00
MO441: Dynamic Role of Macrophage-Inducible C-Type Lectin in the Process of AKI-to-CKD Transition - Wang C, LV L, Liu B, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a global health concern associated with high morbidity and mortality, as well as a high risk of progression to chronic kidney disease (CKD). As a result of phenotype diversity and plasticity, macrophages are recognized as key regulators of (...)
02:00
MO442: COVID-19 Disease Severity and Risk of 12-Month CKD Progression - Lorenzo A, Martínez Manrique M, Ardura P, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been in our daily practice for almost 2 years now. Since the beginning of the pandemic, we have aimed to study its most immediate effects on patients to find the best line of treatment or, at (...)
02:00
MO338: Long-Term Kidney Outcomes After Acute Kidney Injury in Patients With COVID-19 - Khruleva Y, Efremovtseva M, Kobalava Z. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe acute effects of the novel coronavirus infection (COVID-19) on short-term kidney outcomes have been studied, the long-term kidney outcomes after COVID-19-associated acute kidney injury (AKI) in comparison with hospitalized patients without AKI are insufficiently (...)
02:00
MO339: The Effect of Pre-Admission Angiotensin-Converting Enzyme Inhibitor (ACEI) and Angiotensin Receptor Blocker (ARB) Use on the Incidence of Acute Kidney Injury and Mortality in Patients With Septic Shock - Ambrus C, Fejes V, Enyedi V, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIn the early stages of sepsis, the renin–angiotensin–aldosteron system (RAAS) is activated despite adequate volume resuscitation. Overactivity of RAAS might contribute to an inferior outcome in patients with severe sepsis, therefore modulation of RAAS could be (...)
02:00
MO379: Collagen-Derived Peptides in CKD: A Link to Fibrosis - Mavrogeorgis E, Mischak H, Latosinska A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCollagen is a major component of the extracellular matrix (ECM) and has an essential role in the onset and progression of fibrosis and chronic kidney disease (CKD). Collagen alpha-1(I) (col1a1) is the most abundant collagen type in humans and the involvement of (...)
02:00
MO380: Bio-Conductivity Measurement for Electrical Impedance Tomography (EIT) in Chronic Kidney Disease—A Non-Invasive and Portable Monitoring Approach - Yap D, Ka Ying MA E, Yi Oon W, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is an escalating global health concern, and non-invasive means for early CKD detection is eagerly awaited. Kidneys are water- and electrolytes-rich organs with good bio-conductivity. Kidney fibrosis and tubular atrophy are characteristic (...)
02:00
MO407: Clinical Features & Outcome of 352 Covid-19 Positive Maintenance Haemodialysis Patients in Second Covid Wave in Tertiary Care Centre in South India - Chege P, Yadla M. Nephrol Dial Transplant

AbstractBACKGROUNDCoronavirus disease (COVID-19) infection by severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) virus is an ongoing pandemic with high morbidity and mortality rates. The second COVID-19 wave was observed between April–July 2021. Patients with underlying CKD, ? 65 years, (...)
02:00
MO408: Hepatic Steatosis in Patients With Type 2 Diabetes and Chronic Kidney Disease - Adrian T, Hornum M, K. Knop F, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSNon-alcoholic fatty liver disease (NAFLD) is suggested as being a risk factor for chronic kidney disease (CKD). The incidence of NAFLD is rising globally parallel to the increasing incidences of obesity and type 2 diabetes. As diabetes remains the leading cause of CKD (...)
02:00
MO423: Does Renal Dysfunction Improve the Predictive Value of Hatch Score for Postoperative Atrial Fibrillation? - Gjerakaroska Radovikj M, Severova- Andreevska G, Jovev S. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPostoperative atrial fibrillation (POAF) is a frequent arrhythmic complication in cardiac surgery. Studies of this potential complication have not been able to elucidate its aetiology nor to identify the predictors of its occurrence. The aim of this study was to (...)
02:00
MO424: Relationship Between Itch Intensity and Patient-Reported Disease Improvement in Patients With Chronic Kidney Disease-Associated Pruritus Treated With Difelikefalin - Mccafferty K, Walpen S, Schaufler T, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease-associated pruritus (CKD-aP) is a common condition in patients with CKD undergoing haemodialysis (HD), leading to poor sleep quality, reduced quality of life and depression. Difelikefalin is a selective kappa opioid receptor agonist approved in (...)
02:00
MO425: Rosuvastatin Activates Hox13-Usag-1 Pathway and Prevents Renal Fibrosis - Oh D, Yang E, Yoon Lee G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSStatins, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, are primarily cholesterol-lowering drugs that have become standard of care in the primary and secondary prevention of cardiovascular diseases. Apart from lipid-lowering, statins may act beneficially (...)
02:00
MO426: Elucidation of Mechanism of Low-Birth-Weight-Related Fsgs in Rats by Rna-Seq Analysis of Cultured Podocytes From Low-Birth-Weight Rats - Imasawa T, Hirano D, Unoki-Kubota H. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe pathogenesis of low-birth-weight (LBW)-related nephropathy has been considered to be the result of intra-glomerular hyperfiltration during growth due to the presence of low nephron numbers. On the other hand, we hypothesized that there may be pathogenic factor(s) (...)
02:00
MO475: Dapa-CKD Patient Profile: Transposability Assessment in Real-Life Through the CKD-Rein French Cohort - Alencar de Pinho N, Lambert O, Thomas-Delecourt F, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe objective of this observational study was to describe the `DAPA-CKD-like’ population and to assess the burden of illness (comorbidities, cardiovascular (CV) and renal events) and prognosis in patients with CKD in France, compared with those randomized in the (...)
02:00
MO476: Prevalence of Symptoms in End Stage Renal Disease and Their Association With Quality of Life - Nabil H, Chettati M, Fadili W, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSEnd-stage chronic renal disease (ESRD) is an irreversible disease with serious consequences for the life of the patient and perceived as a social and professional handicap. Management of ESRD therefore requires not only control of symptoms and morbidity, but also (...)
02:00
MO477: Predicting 1-Year Mortality After Haemodialysis Start: The Role of the Cha?Ds?-VASC Score - Marques Da Silva B, Mafalda Abrantes A, Branco C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is a significant cause of morbidity, cardiovascular and all-cause mortality. CHA2DS2VASc is a score system used in patients with atrial fibrillation to predict thromboembolic risk. However, it also appears to be useful to predict mortality (...)
02:00
MO478: The Epidemiology of Anca-Associated Vasculitis at a Single Centre Over Two Decades - Storrar J, Alderson H, Brown N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSANCA-associated vasculitis (AAV) refers to a group of conditions in which the end result is systemic injury of small blood vessels, resulting in damage to distinct organ systems including the lung, kidneys, ear, nose and throat. A characteristic, although not (...)
02:00
MO336: Renal Recovery After Acute Kidney Injury Associated to COVID Requiring CRRT During ICU Hospitalization - Molano-Triviño A, Zuñiga E, Camilo Castellanos De la Hoz J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRenal recovery (RR) after AKI is a determinant outcome of future comorbidity and mortality in critical care patients. Related predictive factors remain uncertain.METHODWe retrospectively analyzed patients admitted to ICU between January 2020 and February 2021 from our (...)
02:00
MO337: Higher Antibody Response After 2 Vaccinations With MRNA-1273 as Compared With BNT162B2 and AZD1222 in High-Risk Kidney Patients - Bouwmans P, Messchendorp L, Imhof C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSLower antibody responses after SARS-Cov-2 vaccination have been reported in patients with severely impaired kidney function or patients with kidney replacement treatment. We compared humoral responses and reported adverse events of three vaccines (mRNA-1273, BNT162b2 (...)
02:00
MO369: A Systematic Review to Evaluate the Drivers of Non-Adherence to Albuminuria Testing Guidelines and the Clinical and Economic Impact of Not Identifying CKD Over the Course of Progressive Kidney Function Loss - Garreta Rufas A, Meredith K, Harris J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend regular estimated glomerular filtration rate (eGFR) and albuminuria testing in patients diagnosed with chronic kidney disease (CKD) and those with specific risk factors such as type 2 diabetes (...)
02:00
MO370: Perceptions of Barriers and Mitigating Strategies for Suboptimal Albuminuria Testing: A Global Survey of a Range of Specialists - Garreta Rufas A, Meredith K, Harris J. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRegular estimated glomerular filtration rate (eGFR) and albuminuria testing in patients diagnosed with chronic kidney disease (CKD) and those with specific risk factors such as type 2 diabetes is recommended in The Kidney Disease Improving Global Outcomes (KDIGO) (...)
02:00
MO395: Physical Function, Muscle Force Production and Physical Activity Levels In Peritoneal Dialysis Patients - Vaz Leal D, Pereira L, Inácio M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is a highly predominant worldwide disease, representing an enormous economic burden with profound social implications. In addition to frequent infections and mineral and bone disorders, CKD patients also experience exacerbated mobility (...)
02:00
MO396: Development, Establishment and Validation of in Vitro and EX Vivo Assays of Vascular Calcification - Orth-Alampour S, Holmar J, Jankowski J. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSVascular calcification is one major complication in patients with chronic kidney disease (CKD), with a misbalance in calcium and phosphate metabolism playing a crucial role. The mechanisms underlying vascular calcification have not been entirely revealed to date. As (...)
02:00
MO397: Association of Serum NT-PRO-BNP Level With Cardiometabolic Risk Factors in Different Stages of Chronic Kidney Disease Patients - Alam Ripa R, Chowdhury M, Shahnoor Alam K, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe role of cardiac biomarker, NT-pro-BNP and its rising over time may identify chronic kidney disease (CKD) patients at increased risk of cardiovascular morbidity and mortality. Additionally, this may be correlated with altered cardio-metabolic risk factors (...)
02:00
MO398: Salvianolic Acid C Attenuated Fibrosis Through Enhancer of Zeste Homolog 2 in Fibrotic Kidneys - Ye C, Lin J, Chen D, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSalvianolic acid C (SAC) is a component of Danshen, a widely used herbal medicine for the treatment of renal cardiovascular diseases. Renal interstitial fibrosis is a common pathway of all kinds of chronic kidney diseases progressing to the end-stage of renal (...)
02:00
MO443: Accumulation of REG-1? in Proximal Tubules of a Rat Model of Chronic Kidney Disease: A New Biomarker at the Interface Between Renal Impairment and Neurodegenerative Diseases - Cortijo I, Muyor K, Laget J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) increases the risk of developing cognitive dysfunction and it has been identified as a modifiable risk factor for Alzheimer's disease (AD) [1]. Regenerating family member 1 alpha (Reg-1?) protein, originally identified as a 16 kDa (...)
02:00
MO444: Quercetin, a Novel Exosomes Inhibitor, Alleviates Renal Tubulointerstitial Inflammation and Fibrosis - Yin D, Wang B, Liu B. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSTubulointerstitial inflammation (TI) and tubulointerstitial fibrosis (TIF) are the common pathological manifestations of all progressive chronic kidney diseases (CKD). Exosomes-mediated cellular communication between tubular epithelial cells (TECs) and macrophages (...)
02:00
MO445: Implications of Cardiac Biomarkers in Patients With Renal Insufficiency on Probability of Coronary Angiography and Subsequent Cardiovascular Outcomes - Illum E, Baumbach Z, Linnea Freese Ballegaard E, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRenal insufficiency is associated with an increased risk of cardiovascular morbidity and mortality. Although cardiac troponin remains essential marker for the diagnosis of myocardial injury in the general population, the diagnostic utility remains uncertain in (...)
02:00
MO446: The Prevalence of Mafld in Subjects With Normoglycaemia, Prediabetes and Type 2 Diabetes Without Evidence of Chronic Kidney Disease and its Association With Glomerular Hyperfiltration - Abbate M, Fresneda S, María Yañez A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSWhereas metabolic dysfunction-associated fatty liver disease (MAFLD) reflects multisystem disorders [1], many aspects of the association between MAFLD and extra-hepatic diseases are the issues to study. Glomerular hyperfiltration (GHF) is an early manifestation of (...)
02:00
MO483: Validation of The Kidney Failure Risk Equation in a Portuguese Cohort - Marques Da Silva B, Charreu J, Duarte I, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIn chronic kidney disease (CKD) patients, the risk of kidney replacement therapy (KRT) is highly variable. In 2011, Tangri et al. developed the kidney failure risk equations (KFRE) to predict the 2- and 5-year probability of requiring kidney replacement therapy (KRT). (...)
02:00
MO484: Gender Differences in the Incidence of End-Stage of Renal Disease in Okinawa - Fukuhara C, Kohagura K, Iseki K. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe incidence of chronic kidney disease (CKD) and its progression to end-stage renal disease (ESRD) differ between genders, so it can be surmised that the incidence of ESRD is different between males and females. Acceptance of dialysis therapy may not necessarily be (...)
02:00
MO485: Chronic Kidney Disease in Patients With Lung Transplant - Luisa Serrano Salazar M, Rubio Arboli L, Sánchez-Sobrino B, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe incidence of chronic kidney disease (CKD) in patients with lung transplantation (LTx) has increased over the last decades.Progression factors recognized in the development of CKD are: older age and comorbidity of recipients, immunosuppressive (IS) toxicity and (...)
02:00
MO486: Comparison of Hospitalization Lengths of Stay Among a National Cohort of Advanced CKD Patients Treated With Conservative Management Vs. Dialysis - You A, Kalantar-Zadeh K, Narasaki Y, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSWhile dialysis has been the prevailing treatment paradigm in advanced CKD patients progressing to ESRD, this treatment approach may lead to a decline in physical function, loss of independence, and greater healthcare utilization among certain subgroups. We sought to (...)
02:00
MO515: Mortality Differences Between Men and Women With Chronic Kidney Disease in the Irish Health System: The National Kidney Disease Surveillance Programme - Stack A, Laird M, Glynn L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease is associated with higher mortality compared with the general population, but mortality differences between men and women with CKD are poorly understood. Although the prevalence of CKD is consistently higher in women than in men, emerging (...)
02:00
MO516: Clusters of Chronic Conditions Across the Spectrum of Kidney Function: A Nationwide Cohort Study - Sullivan M, Gasparini A, Mair F, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMultimorbidity is the presence of two or more chronic conditions. Patients with multimorbidity suffer from a high treatment burden as they have to cope with numerous medications and attend multiple specialists. Some chronic conditions co-exist in predictable ways, (...)
02:00
MO517: A Polygenic Risk Score for Reduced EGFR is Associated With Adverse Events in a Chronic Kidney Disease Cohort —the German Chronic Kidney Disease Study - Steinbrenner I, Yu Z, Jin J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSOver 10% of the adult population worldwide is affected by chronic kidney disease (CKD). CKD is associated with an increased risk of kidney failure (KF), cardiovascular events and mortality. CKD is defined and staged by estimated glomerular filtration rate (eGFR), the (...)
02:00
MO518: Chronic Kidney Disease in Primary Care and the Risk of Cardiovascular Comorbidity and Mortality - Borg R, Kriegbaum M, Klinten Grand M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe prevalence of chronic kidney disease (CKD) is increasing globally. Often, the condition develops silently over time, with no or only a few symptoms in earlier stages. Therefore, early recognition in primary care may have an important role in ensuring diagnosis and (...)
02:00
MO329: Acute Kidney Injury (AKI) is Associated With Increased in-Hospital Mortality and With Impairment of Renal, Lung, Motor and Immune Function 1 Year After Discharge For COVID-19 - Morosini U, Marengo M, Prenna S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAKI is the most frequent complication after respiratory failure in COVID-19. AKI increases mortality risk, length of hospital stay and healthcare costs, with possible progression towards CKD. Study aims: (1) evaluation of AKI incidence in 1020 COVID-19 hospitalized (...)
02:00
MO010: Parameters Associated with Progression, Prognosis and Tolvaptan Indication in Autosomal Dominant Polycystic Kidney Disease (ADPKD) - Gkika V, Louka M, Fokas S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe identification of possible risk factors for the progression of autosomal dominant polycystic kidney disease (ADPKD) is an emerging field, especially after the introduction of tolvaptan as the first disease-specific treatment. The present study aims to explore the (...)
02:00
MO019: Preclinical Efficacy of Direct AMPK Activation with a Novel Small Molecule–PXL770–For the Treatment of Autosomal Dominant Polycystic Kidney Disease - Gluais Dagorn P, Buchholz B, Bange H, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAutosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease. It is caused by mutations in the PKD1 gene, and to a lesser extent PKD2. In this context, accumulating evidence has suggested a potential role of reduced AMP-activated (...)
02:00
MO028: Kidney biopsy in females with Fabry disease is an important tool to establish the indication for Fabry-specific therapy - Emanuela Rusu E, Zilisteanu D, Mihaela Ciobotaru L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSFabry disease (FD) is a rare lysosomal storage disease causing progressive kidney, nervous system and heart disorders. Specific therapy may stop or mitigate disease progression, but is very expensive and results depend significantly on early initiation of treatment. (...)
02:00
MO047: Biallelic pathogenic variants in ROBO1 associate with syndromic CAKUT - Münch J, Engesser M, Schönauer R, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCongenital anomalies of the kidney and urinary tract (CAKUT) represent the most common cause of chronic kidney failure in children. Despite growing knowledge of the genetic causes of CAKUT, the majority of cases remain etiologically unsolved. Genetic alterations in (...)
02:00
MO048: Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases - LI Y, Cheng Y, Consolato F, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSUMOD is a major risk gene for monogenic and complex forms of kidney disease. The encoded kidney-specific protein uromodulin is the most abundant protein in urine and related to chronic kidney disease, hypertension and pathogen defense. Through basolateral release from (...)
02:00
MO069: Therapeutic Effects of Semaglutide as Mono and Combination Treatment with Lisinopril in a Mouse Model of Hypertension-Accelerated Diabetic Kidney Disease - Christensen M, Dalbøge L, Secher T, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSObesity, hyperglycemia and hypertension are critical risk factors for the onset and progression of diabetic kidney disease (DKD). Emerging evidence suggests that sodium-glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor (GLP-1R) agonists (...)
02:00
MO070: Noncanonical IKKS and the Type 1 Interferon Pathway Activate Inflammation and Cell Death in Tubular Cells and Contribute to Renal Injury - Marcela Córdoba David G, García-Giménez J, Ortiz A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSDeleterious consequences of type 1 interferons (T1-INFs) in the renal tissue have been envisioned in the context of viral and autoimmune diseases and in clinical therapies dealing with their administration.(1–3) Moreover, a participation of the T1-INF pathway has been (...)
02:00
MO007: Clinical and Laboratory Profile of Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) - Gkika V, Louka M, Kanellopoulou K, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRecent advances in the treatment of autosomal dominant polycystic kidney disease (ADPKD) highlight the interplay between the clinical and laboratory profile of the disease. This study aims to present the baseline characteristics of patients followed in a large ADPKD (...)
02:00
MO018: The Need for Routine Native Nephrectomy in the Work-Up for a Kidney Transplantation in Autosomal Dominant Polycystic Kidney Disease Patients - Geertsema P, Gansevoort R, Koorevaar I, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIn some patients with autosomal dominant polycystic kidney disease (ADPKD), one or both native kidneys are removed in the work-up for kidney transplantation. There is no consensus if and when a nephrectomy should be performed. Some centers advocate to routinely (...)
02:00
MO023: Chronic kidney disease in HELIX syndrome - Prot-Bertoye C, Knebelmann B, Bourrat E, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRare genetic diseases affecting claudins (CLDN), integral proteins located at intercellular tight junction that determine the ionic selectivity and permeability of the paracellular pathway, highlighted the importance of paracellular transport in body homeostasis. (...)
02:00
MO043: Role of the I416L variant of complement factor I in the occurrence of thrombotic microangiopathy among patients of African ancestry - Nobile G, Doreille A, Raymond L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSComplement dependent hemolytic and uremic syndrome (c-HUS) predisposes to hypertensive crisis and chronic hypertension. Reciprocally, hypertensive crisis may precipitate thrombotic microangiopathy (TMA) via endothelial shear stress. Patients of African ancestry have (...)
02:00
MO044: Cellular mechanism of the exceptional dominant transmission in NPHS2-associated glomerulopathy - Seidl D, Antal-Kónya V, Schay G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMutations of NPHS2 cause autosomal recessive steroid-resistant nephrotic syndrome (SRNS). The encoded podocin, a key component of the slit diaphragm, homo-oligomerizes through two C-terminal oligomerization sites. We formerly found that specific podocin variants may (...)
02:00
MO067: Role of ANT2 in the Development of Obesity-Induced Chronic Kidney Disease - Permyakova A, Hamad S, Yosef O, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSObesity, a widespread condition with an ever-increasing prevalence, imposes a great medical concern since it serves as a risk factor for a wide range of conditions, including the development of chronic kidney disease (CKD). Lipid accumulation and impaired fatty acid (...)
02:00
MO068: Paraoxonase 2 Protects the Kidney Tissue from Aldosterone-Promoted Oxidative Stress in Milan Normotensive Rats Strain - Suzumoto Y, Manco G, Capasso G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSKidney plays a pivotal role on the maintenance of blood pressure by the regulation of sodium reabsorption. Aldosterone sensitive distal nephron finely tunes salt reabsorption through several transporters, including the epithelial sodium channel (ENaC). Alteration in (...)
02:00
MO206: HLA Frequency in A Spanish Transplant Patients Cohort With ANCA-Associated Vasculitis - Martin I, Mínguez Toral I, Castillo Rodriguez E, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSANCA-associated vasculitis (AAV) is an autoimmune disease that causes end-stage renal disease in ?20%–25% of patients who develop kidney failure with progression to end-stage kidney disease with requirement of renal replacement therapy. Previous studies have found a (...)
02:00
MO012: Development of an Accurate Automated Segmentation Algorithm to Measure Total Kidney Volume in ADPKD Suitable for Clinical Application (The Cystvas Study) - Taylor J, Thomas R, Metherall P, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSA major barrier to the routine adoption of total kidney volume (TKV) as a clinical biomarker of disease for autosomal dominant polycystic disease (ADPKD) is the significant human operator time required even by experienced analysts (typically, 45–90 min per patient). (...)
02:00
MO017: The Impact of Pre-Transplantation Nephrectomy on Quality of Life in Patients With Autosomal Dominant Polycystic Kidney Disease - Geertsema P, Gansevoort R, Leliveld-Kors A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIn autosomal dominant polycystic kidney disease (ADPKD), the enlarged kidneys can cause clinical problems, for instance pain or gastro-intestinal complaints, recurrent infections, or cause a lack of space for a kidney transplant. In selected ADPKD patients, a (...)
02:00
MO024: Effect of green tea on top of enzyme replacement therapy in patients with Fabry disease: a molecular biology approach - Bertoldi G, Carraro G, Ravarotto V, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSFabry disease (FD) is an X-linked rare disease characterized by deficient expression and activity of alpha-galactosidase A and consequent lysosomal accumulation of Gb3 and derivatives in various organs. Notwithstanding the first-line treatment with enzyme replacement (...)
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MO034: Novel MUC1 variant identified by massively parallel sequencing explains interstitial kidney disease in a large Dutch family - de Haan A, Eijgelsheim M, Rump P, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) can be caused by a wide variety of systemic and renal disorders. In approximately 20% of patients, the cause of CKD remains unknown. Previous studies have shown that massively parallel sequencing (MPS) can be a valuable diagnostic tool in (...)
02:00
MO035: Education needs in diagnosing rare renal diseases: a clinician survey - Rohani-Montez C. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThere are approximately 300 inherited, congenital or acquired rare kidney diseases known. However, there is a significant delay in their diagnosis, which may result in inappropriate and potentially harmful testing or treatment due to misdiagnosis, or other adverse (...)
02:00
MO059: Trajectory Analysis of the Kidney Organoid Proteome Extends its Modelling Potential of Disease - Lassé M, Bonin L, El Saghir J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSKidney organoids are a valuable and innovative model to understand genetic diseases, kidney development and transcriptomic dynamics. However, their proteome has not been analyzed so far. It is unclear how their proteome changes during differentiation, and if more (...)
02:00
MO009: Creatine-Kinase Elevation in Autosomal Dominant Polycystic Kidney Disease Patients on Tolvaptan Treatment - Rodríguez Espinosa D, Jesus Broseta Monzo J, Cuadrado E, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAutosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cause of end-stage kidney disease. Currently, tolvaptan is the only treatment that has proven to delay disease progression. The most notable side-effect of this therapy is drug-induced (...)
02:00
MO016: Feasibility and Effectiveness of Short-Term Ketogenic Interventions in Autosomal Dominant Polycystic Kidney Disease (ADPKD): Results from the Reset-Pkd Study - Oehm S, Steinke K, Arjune S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSOver the last years, there has been increasing evidence that defects in the energy metabolism of polycystic kidney disease (PKD) cyst lining cells, especially increased glucose dependency and defects in fatty acid oxidation, may underlie the pathogenesis of ADPKD, (...)
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MO042: Biallelic variants in TTC21B as a rare cause of early-onset arterial hypertension and tubuloglomerular kidney disease - Olinger E, Phakdeekitcharoen P, Caliskan Y, et al. Nephrol Dial Transplant

AbstractBACKGROUNDMassively parallel sequencing (MPS) has propelled precision medicine into the next generation. With genetic data more accessible than ever, the focus has now shifted from obtaining data to converting the acquired data into applicable clinical information. A major obstacle to (...)
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MO057: Serum Irisin and Prediction of Cardiovascular Events in Elderly Patients with CKD Stage 3–5 - Del Mastro T, Arcidiacono T, Bologna A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIrisin is a circulating myokine released by skeletal muscle after exercise. Its production decreases in chronic kidney disease (CKD) as a potential consequence of sarcopenia and physical inactivity. Irisin produces beneficial effects in glucose and lipid homeostasis: (...)
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MO058: Do Renal Biopsies Assist Understanding of Loin Pain Hematuria Syndrome? - Sharma A, Prasad B, Jafari M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSLoin pain-hematuria syndrome (LPHS) first described in 1967 is a complex and poorly understood rare disease, with a prevalence of 0.012%. It predominantly affects young women in their late 20s and early 30s2. Patients with LPHS experience extreme flank (loin) pain (...)
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MO214: Health-Related Quality of Life Among Patients With Anca Vasculitis - Nic an Riogh E, Gogarty E, Reedy B, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAnti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a debilitating disease that can have a significant impact on a patient's quality of life. The aim of this study was to assess the longitudinal quality of life amongst those diagnosed with AAV using (...)
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MO215: Intrarenal Single Cell Sequencing of MPO-Anca Associated Glomerulonephritis Patients Reveal Novel Targetable Treatment Options - Zhong Y, Ooi J. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe etiopathogenesis underlying myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (MPO-ANCA-GN) remains incompletely understood. Furthermore, there are only limited treatment options and treatment resistance of MPO-ANCA-GN is still a (...)
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MO238: Erythroid ACKR1 Expression has a Protective Effect on the Development of Experimental Glomerulonephritis - Artinger K, Novitzky-Basso I, Kirsch A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe overwhelming majority of individuals of West African ancestry carry an ‘erythroid silent’ FyB(ES) SNP in the promoter region of ACKR1 that causes a selective loss of ACKR1 in erythroid cells but does not affect its expression in endothelial cells. The FyB(ES) (...)
02:00
MO003: Upregulation of NADH/NADPH Oxidase 4 by Angiotensin II Induces Podocyte Apoptosis - Ha T, Ha D. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSOxidative stress induced by non-hemodynamic effects of angiotensin II in podocytes participates in the development of glomerular injury and proteinuria. We studied the pathophysiologic roles of oxidative stress in angiotensin II-induced podocyte apoptosis.METHODMouse (...)
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MO015: The Interaction of Gender and Genotype in the Development of Polycystic Liver Disease in ADPKD - Cong Eugene Chen W, Ong A, Gittus M. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSLiver cysts are the most common extra-renal manifestation in autosomal dominant polycystic kidney disease (ADPKD) and polycystic liver disease (PLD) may result in significant morbidity in a proportion of patients. The major objective of this study was to investigate (...)
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MO029: Urinary biomarkers in the progression of autosomal dominant polycystic kidney disease - Carolina Santos A, Novais C, Matos A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAutosomal dominant polycystic kidney disease (ADPKD) is a hereditary disease characterized by the formation and growth of renal cysts, affecting the decrease of renal function, which may lead to end-stage renal disease (ESRD). Due to the enormous intrafamilial (...)
02:00
MO040: Development of BBP-711, a small molecule inhibitor of glycolate oxidase for primary hyperoxaluria type 1 and recurrent kidney stone formers - Sinha U, Rajasingham T, Xavier Fernandez M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSBBP-711 is an investigational small molecule inhibitor of glycolate oxidase (GO), currently in development for the treatment of primary hyperoxaluria type 1 (PH1) and recurrent nephrolithiasis. Selection of BBP-711 as a drug candidate followed structural activity (...)
02:00
MO041: Impaired ACE2 glycosylation and protease activity lowers susceptibility to SARS-COV-2 infection in Gitelman/Bartter syndromes - Bertoldi G, Ravarotto V, Sgarabotto L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSACE2, part of the counter-regulatory arm of the renin–angiotensin system, serves both as protective toward oxidative stress and cardiovascular remodeling and as a key entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 has two isoforms, (...)
02:00
MO053: Are Renal Prognostic Markers Different in Patients with Exostosin 1/2 Positive or Negative Membranous Lupus Nephritis? A Single Center Experience in Turkey - Ebru Eser Z, Turgutalp K, Karabulut Y, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRecently, prognostic importance of antibodies in primary membranous nephropathy is well defined. However, knowledge about antibodies related to disease activity in membranous lupus nephritis (MLN) is limited. Exostosin1 and exostosin2 (EXT1/2) are novel antibodies (...)
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MO054: Histological Findings in Drug-Induced Acute Interstitial Nephritis - Sarra H, Harzallah A, Khadhar M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute interstitial nephritis (AIN) represents an important cause of acute kidney injury. The most common etiology of AIN is drug-induced disease. Definitive diagnosis of AIN requires renal biopsy. Despite this, there is a lack of consensus regarding precise (...)
02:00
MO065: The Association of Glomerular Neural Cell Adhesion Molecule-1 Expression with Membranous Lupus Nephritis and the Injury of Central Nervous System - Liu Y, Zhang M, Luo S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSNeural cell adhesion molecule-1 (NCAM-1) has been found to be associated with central nervous system (CNS) injury in patients with lupus nephritis in small case series. This study aimed to explore the relationship between glomerular NCAM-1 expression and CNS injury in (...)
02:00
MO066: The Role of Platelet-Derived Growth Factor in Focal Segmental Glomerulosclerosis - Jia T, Xu T, Smeets B, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSFocal segmental glomerulosclerosis (FSGS) describes a primary disease of podocytes (podocytopathy) and a secondary consequence of severe or progressive glomerular damage. No specific treatment options exist for FSGS, with many patients progressing to end-stage kidney (...)
02:00
MO077: Systemic Therapy with a Single-Dose Kidney-Targeted Bioengineered VEGF Construct Improves Stenotic Kidney Hemodynamics in Experimental Renovascular Disease - Chade A, Bidwell G. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSWe recently developed a construct of an elastin-like polypeptide fused to VEGF (ELP-VEGF) and showed its efficacy to target and protect the kidney after single systemic administration in a swine model of unilateral renovascular disease (RVD) via therapeutic (...)
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MO078: Dietary Supplementation with Cysteine During Pregnancy Rescues Maternal Chronic Kidney Disease-Induced Hypertension in Male Rat Offspring: The Impact of Hydrogen Sulphide and Microbiota-Derived Tryptophan Metabolites - Tain Y, Hsu C. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMaternal chronic kidney disease (CKD) is linked to offspring hypertension. Gut microbiome and its tryptophan metabolites, nitric oxide (NO) and renin–angiotensin system (RAS) are closely related to the development of hypertension. Hydrogen sulphide (H2S) has shown (...)
02:00
MO079: Treatment with Nebivolol Ameliorates Renovascular Alterations and Oxidative Stress in Tenofovir-Induced Nephrotoxicity in Rats - Moura Nascimento M, Bernardo D, Carolina de Braganca A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSHuman immunodeficiency virus (HIV) continues to be a major global public health issue, having claimed millions of lives so far. Tenofovir disoproxil fumarate (TDF), a widely prescribed component in antiretroviral regimens for HIV treatment, has been associated with (...)
02:00
MO095: Normocalcaemic Hyperparathyroidia Diagnosed by Calcium Load - Lemoine S, Dang J, Dubourg L. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCalcium load is usually used in clinical practice to diagnose a normocalcaemic hyperparathyroidia in stone disease. However, the calcium load developed by Pak and colleagues has been described in very few patients. We aimed to provide data about calcium load in a (...)
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MO240: The Evolution and Epidemiology of Membranous Nephropathy at a Single Centre Over Two Decades - Storrar J, Gill-Taylor T, Chinnadurai R, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMembranous nephropathy (MN) commonly presents with nephrotic syndrome and carries significant risk of progression to end-stage kidney disease (ESKD) (33% without treatment, 10%–20% with). Patients may spontaneously remit (up to 40%), but are also at risk of relapse. A (...)
02:00
MO241: Nets and Terminal Complement Pathway as Potential Biomarkers for Complement Overactivation Assessment in Anca-Associated Vasculitis - Guillen-Olmos E, Palomo M, Alba M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSClinical, in vitro, and animal model-derived evidence has demonstrated a critical involvement of the alternative complement pathway (aCP) in the pathogenesis of ANCA-associated vasculitis (AAV). In this regard, neutrophil extracellular traps (NETs) have been suggested (...)
02:00
MO242: Intrarenal Single Cell Sequencing of Hepatitis B Virus Associated Membranous Nephropathy - Zhong Y. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe pathogenesis underlying hepatitis B virus (HBV)-associated membranous nephropathy (MN) remains incompletely understood.METHODTo decipher the etiopathogenesis of HBV-associated MN, intrarenal single-cell RNA sequencing (scRNA-seq) was applied to the kidney biopsy (...)
02:00
MO243: Intestinal Fatty-Acid Binding Protein: A Potential Biomarker of Enterocyte Damage in IGA Nephropathy? - Pohjonen J, Kaukinen K, Mustonen J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAn abundance of inflammatory cells has been found in duodena of IgA nephropathy (IgAN) patients [1, 2]. The degree of intestinal inflammation was shown to correlate with the amount of proteinuria and haematuria in IgAN [3]. Serum intestinal fatty-acid-binding protein (...)
02:00
MO276: Renal Tubular CD24 Upregulation Aggravates Folic Acid-Induced Acute Kidney Injury Through Inhibition of Regulatory T Cells in Mice - Schwartz D, Grupper A, Zubkov A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is characterized by cell death and inflammation. CD24 is a sialoglycoprotein which is induced during tissue damage and is not expressed in matured renal tissue. We explored the role of CD24 in the pathogenesis of folic acid-induced AKI (...)
02:00
MO277: Effect of P-Cresyl Sulfate in Cardiorenal Axis in Mice - Alexandre Falconi C, Victoria Cruz Junho C, Fogaça-Ruiz F, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSUremic toxins (UT) are extremely relevant for the understanding of pathologies of the cardiovascular system once kidney and heart have a close relationship and share different functions. UT are divided into three groups according to physicochemical characteristics: (...)
02:00
MO278: Immunolandscaping of Rhabdomyolysis-Induced Acute Kidney Injury - Rao S, Casemayou A, Buleon M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) accounts for 13.3 million cases per year worldwide and further responsible for 1.7 million deaths per year [1]. Increasing incidence of AKI, progression toward CKD or end-stage renal disease (ESRD), affect on long term health, high mortality, (...)
02:00
MO279: Vitamin D Supplementation Attenuates Hyperandrogenemia-Associated Acute Kidney Injury in Female Sprague-Dawley Rats - Masjedi F, Roozbeh J, Karimi Z. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPolycystic ovary syndrome (PCOS) is closely related to the onset and development of metabolic abnormalities. However, the correlation between PCOS and kidney injury has not been clarified, and the underlying mechanism remains unknown. Vitamin D therapy has beneficial (...)
02:00
MO008: Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) without a Clear Family History have Rapid Progression and Poor Prognosis - Gkika V, Louka M, Fokas S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSA small percentage of patients with autosomal dominant polycystic kidney disease (ADPKD) have no clear family history. The clinical course and prognosis of the disease in this subgroup of patients may be different. The present study investigates the progression and (...)
02:00
MO014: Development and Validation of the Thirst Distress Scale for Patients with Autosomal Dominant Polycystic Kidney Disease - Gül Özcan ?, Bek S, Eren N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAbundant water intake is advised for patients with autosomal dominant polycystic kidney disease (ADPKD) Meijer and Casteleijn (Riding the waves: evidence for a beneficial effect of increased water intake in autosomal dominant polycystic kidney disease patients? (...)
02:00
MO026: IgA-nephropathy in Alport syndrome patients: one center data - Aksenova M, Stolyarevich E, Povilaitite P. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe association between Alport syndrome (AS) and IgA-nephropathy (IgAN) recently shown suggests that the abnormal glomerular basement membrane (GBM) resulting from the pathogenic COL4A3/A4/A5 variants may predispose to immune-mediated injury. The aim of study was to (...)
02:00
MO038: Mineral bone density assessment in patients affected by cystinuria - D'ambrosio V, Ambrogio M, Gremese E, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCystinuria is a rare genetic disease characterized by impaired tubular transport of cystine and other dibasic amino acids that leads to cystine renal calculi. Although being a rare condition, cystinuria is the most frequent monogenic cause of nephrolithiasis (...)
02:00
MO004: Hidden Patterns of T Cell and B Cell Phenotypes seen Through Machine Learning Algorithms in End-Stage Renal Disease - Lioulios G, Fylaktou A, Xochelli A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSEnd-stage renal disease (ESRD) is essentially a chronic inflammatory state and, consequently, it engenders detrimental effects on the immune system. Due to the specific uremic environment, multiple phenotypic lymphocyte alterations are described, similar but not (...)
02:00
MO013: Relationship between Disease Awareness and Severity of Kidney Disease in Autosomal Dominant Polycystic Kidney Disease Patients - Dogan E, Eren N, Gül Özcan ?, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAutosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease with diffuse cysts in both kidneys and is responsible for 5–10% of end-stage renal disease Levy and Feingold (Estimating prevalence in single-gene kidney diseases (...)
02:00
MO025: Long-term follow-up of patients with autosomal dominant polycystic kidney disease treated with tolvaptan - Martins Muñoz J, De Lorenzo A, Espinel L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAutosomal dominant polycystic kidney disease (ADPKD) is the most common inherited renal disease characterized by the formation of cysts that destroy normal renal parenchyma. Tolvaptan (vasopressin antagonist) is the only drug approved today to slow disease (...)
02:00
MO032: Autosomal dominant tubulointerstitial kidney diseases (ADTKD): single center cohort - Jorge S, Silveira C, Rodrigues M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSADTKD represents a recently described group of kidney diseases, characterized by chronic interstitial nephritis (CIN), in most cases hereditary, with an autosomal dominant inheritance pattern, subclassified according to its genetic cause, when identified. Mutations in (...)
02:00
MO033: Parathyroid hormone determination as an early predictor of progression in autosomal dominant polycystic kidney disease - Viera Ramírez E, Castillo Rodriguez E, Martin I, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSTotal kidney volume (TKV) in patients with autosomal dominant polycystic kidney disease (ADPKD) is a known progression factor in these patients. Low levels of klotho and high levels of FGF23 in the blood of patients with ADPKD have been correlated with higher TKV even (...)
02:00
MO512: Association of Urinary Biomarkers and Accelerated, Age-Related Decline in Measured Gfr - Marie Andreassen R, Melsom T, Odvar Eriksen B, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSUrinary albumin excretion (UAE) is considered as a risk marker for chronic kidney disease (CKD), but the exact pathophysiological mechanisms are not known. Studies have shown that urinary orosomucoid excretion (UOE) is associated with general endothelial dysfunction (...)
02:00
MO513: Implications of Using Various Equations to Estimate Glomerular Filtration Rate in the GNC (NAKO) Study - Lipovsek J, Schaeffner E, Heid I, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSGlomerular filtration rate (GFR) is the most common measure of kidney function. Measuring GFR is often infeasible in routine clinical practice and population studies, where it is estimated instead from blood biomarkers. Three currently recommended equations, (...)
02:00
MO514: Cardiorenal Outcomes Associated With Oral Anticoagulant Use in Patients With Atrial Fibrillation - Mazhar F, Trevisan M, Hjemdahl P, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSNovel oral anticoagulants (NOAC) are currently the first-line choice for stroke prevention in patients with atrial fibrillation (AF), as they have a better risk/benefit profile compared with vitamin K antagonists (VKA). Secondary analyses of trials suggest that NOAC (...)
02:00
MO433: Nitric-Oxide Precursors and Dimethylarginines as Risk Factors for Accelerated GFR Decline in the Non-Diabetic General Population - Balteskard Rinde N, Therese Enoksen I, Melsom T, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSNitric oxide (NO) deficiency is associated with endothelial dysfunction, hypertension, vasoconstriction, atherosclerosis and chronic kidney disease (CKD) [1]. Reduced NO bioavailability is hypothesized to play a vital role in kidney function impairment and CKD. The (...)
02:00
MO434: Bemcentinib Targets Macrophage and Mesangial Cells in Renal Fibrosis - Magnus Grøndal S, Hodneland Nilsson L, Blø M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRenal fibrosis, a progressive process of extracellular matrix accumulation leading to renal failure, lacks effective treatment. Expression of the AXL receptor tyrosine kinase has been implicated in kidney injury and mesangial proliferation [1]. Inhibition of AXL (...)
02:00
MO463: Machine Learning-Based Prediction of Mortality and Risk Factors in Patients With Chronic Kidney Disease Developed With Data From 10000 Patients Over 11 Years - Ibeas J, Galles O, Monill N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAround the globe, over 850 million patients suffer from chronic kidney disease (CKD). These have associated with high mortality rates, in particular when undergoing renal replacement therapies (RRT) such as dialysis, reaching up to 10% a year, and therefore, are (...)
02:00
MO464: Long-Term Renal Outcomes After ST-Elevation Myocardial Infarction Treated by Percutaneaous Coronary Intervention - Legras M, Amaz C, Bochaton T, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAmong patients with ST-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI), short- and long-term renal function evaluations are of prime importance. Most studies have focused on short-term renal dysfunction and acute kidney (...)
02:00
MO465: Molecular Mechanisms of Vascular Ageing in Children With Chronic Kidney Disease - Bartosova M, Zhang C, Herzog R, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPaediatric patients with chronic kidney disease (CKD) develop significant atherosclerosis and vascular calcifications until early adulthood. Largely devoid of confounding lifestyle related factors and underlying disease mostly limited to congenital abnormalities of (...)
02:00
MO466: Impact of Renal Insufficiency on Choice of Rhythm or Rate Control in Atrial Fibrillation and Subsequent Effects on Cardiovascular and Mortality Outcomes - Baumbach Z, Illum E, Linnea Freese Ballegaard E, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAtrial fibrillation remains the most common sustained arrhythmia in the general population, with prevalence inversely correlated with renal function. Management of atrial fibrillation relies on either rhythm control or rate control, however, the choice of treatment in (...)
02:00
MO511: Epidemiology of Idiopathic Nephrotic Syndrome in Children Before and During Covid-19 Pandemic in Paris Area - Thenot V, Parmentier C, Boyer O, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe aetiology of idiopathic nephrotic syndrome (INS) remains partially unknown. Viral infections have been reported to be associated with INS onset and relapse. The COVID-19 pandemic led to several national lockdowns aimed at limiting virus transmission. In France, (...)
02:00
MO421: Chronic Kidney Disease is Associated With Cardiac Downregulation of Vascular Endothelial Growth Factor a (VEGFA) and Development of Diastolic Dysfunction: Epigenetics and Micrornas - Chade A, Eirin A. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPatients with chronic kidney disease (CKD) have a higher risk to develop heart failure with preserved ejection fraction (HFpEF). We showed in a swine model of CKD with diastolic dysfunction and cardiac remodelling that these cardiac features are associated with (...)
02:00
MO422: Strong Positive Association Between GFR and the Urine-To-Plasma Urea Concentration Ratio in Patients With Sickle Cell Disease. Possible Functional Meaning - Bankir L, Lionnet F, Saint Jacques C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSickle cell disease (SCD) induces a decline in urine concentration and progressive deterioration of kidney (K) function. Hyperfiltration is often observed before this decline, and plasma urea is low. Oral urea or hydroxyurea improves the condition of these patients (...)
02:00
MO459: Characterization of Adrenal Gland Derived Mediators of Vascular Calcification - Bhargava S, Orth-Alampour S, Gayrard N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAdrenal glands participate in cardiovascular physiology and pathophysiology via the synthesis and secretion of various well-known compounds like mineralocorticoids, amine peptides and glucocorticoids. In this study, a previously unknown systemic function of adrenal (...)
02:00
MO460: The Association of Beta-Hydroxybutyrate and Kidney Function Decline in the General Population—Results From the Prevend Study - Knol M, van der Vaart A, Vart P, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSBeta-hydroxybutyrate (BHB), a ketone body, has shown to be renoprotective in various disease-specific preclinical studies. The underlying mechanism of this renoprotective effect might be via the reduction of inflammation, apoptosis, oxidative stress, and fibrosis. (...)
02:00
MO461: A Novel Chronic Kidney Disease to HFpEF Connection: Inflammatory Signaling, Micro-RNAs, and NF-KB - Chade A, Mohamed T, Miller J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is an independent risk factor for heart failure with preserved ejection fraction (HFpEF), a progressive condition that affects ?50% of patients in dialysis. We developed a swine model of CKD-HFpEF and showed that renal inflammatory (...)
02:00
MO462: Change in KDIGO Kidney Risk Category With Semaglutide Treatment—A Post Hoc Analysis of the Sustain 6 Trial - Tuttle K, Bain S, Cherney D, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSGlucagon-like peptide-1 receptor agonists, such as semaglutide, have been associated with reductions in albuminuria, and may preserve estimated glomerular filtration rate (eGFR) in people with type 2 diabetes (T2D). However, it has not been explored whether treatment (...)
02:00
MO487: Rates of Hyperkal a EMIA and Management Patterns in a Tertiary Outpatient Renal Clinic - Rosati E, D'ambrosio V, Baccaro R, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe optimal ambulatory management of hyperkalaemia (HK) in patients with chronic kidney disease (CKD) is still an important unmet challenge. Common strategies include dose reduction or discontinuation of nephroprotective medications (e.g. renin-angiotensin-aldosterone (...)
02:00
MO488: Serum P-CRESYL Sulfate Level is an Independent Marker of Peripheral Arterial Stiffness as Assessed Using Brachial-Ankle Pulse Wave Velocity in Patients With Non-Dialysis Chronic Kidney Disease Stage 3–5 - Chang Y, Tang C, Hsu B. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSp-cresyl sulfate (PCS) is associated with inflammation and its contribution to cardiovascular damage in patients with chronic kidney disease (CKD). The brachial-ankle pulse wave velocity (baPWV) is a simple marker to assess the peripheral artery stiffness (PAS) and is (...)
02:00
MO489: Weight Change and Risk of Depression in Patients With Diabetic Kidney Disease: A Nationwide Population-Based Study - Sang Choi H, Ryon Oh T, Heon Suh S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSeveral studies have reported that depression has a high prevalence in patients with diabetes or chronic kidney disease. However, the relationship between weight changes and the risk of depression has not been elucidated in patients with diabetic kidney disease (...)
02:00
MO490: Fast and High Phosphate Reduction With Lanthanum Dioxycarbonate Versus Selevamer In In-Vivo Study - Khare A, Pramod G. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSOver 7 million patients suffer from end-stage kidney disease (ESKD) worldwide [1]. Due to low kidney function, patients often become hyperphosphatemic, which leads to an increased risk of death [2]. Patients usually rely on dietary restrictions and phosphate (P) (...)
02:00
MO410: Early Endothelial Glycocalyx Injury Damage Associated With Further Kidney Dysfunction in Hiv Patients: Five Years Follow-Up - Gadelha Cavalcante M, Cavalcante Meneses G, Bezerra G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSHIV patients have an increased risk of chronic kidney disease (CKD) development. Endothelial dysfunction was previously associated with kidney dysfunction markers. This study aims to investigate the association between renal markers and renal dysfunction biomarkers (...)
02:00
MO239: Clinical Evaluation of Immunological and Clinical Recurrence of Immune-Mediated Nephropathies after SARS-COV-2 Vaccine - Musetti C, Fornara L, Cantaluppi V. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe mass vaccination for COVID-19 has raised new concerns for patients with immune-mediated nephropathies: there is a small but growing literature of case-reports linking SARS-CoV-2 vaccines with heightened off-target immune responses leading to de novo or relapsing (...)
02:00
MO252: Complement 3 Deposits on Renal Tubule and Glomeruli in Phospholipase A2 Receptor-Related Idiopathic Membranous Nephropathy - Cui H, LI C, LI H, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSEvidence shows galactose-deficient IgG4 is able to act complement system via lectin pathway in phospholipase A2 receptor (PLA2R) related idiopathic membranous nephropathy (IMN). However, the severity of PLA2R-related IMN runs parallel with neither the electron (...)
02:00
MO253: Interstitial Fibrosis in Anca-Associated Vasculitis: MPO Versus PR3-A Single-Center Experience - Benito-García S, Marco Rusiñol H, Arce Y, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAnti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a necrotizing vasculitis characterized by inflammation of small blood vessels, being the kidney one of the most frequently affected organs. AAV has a high morbidity and mortality, developing (...)
02:00
MO211: Variability of Proteinuria in Nephrotic Syndrome: GC1008 PH2 Trial in FSGS - Lin J, Hariri A, Accomando B. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSTreatment-resistant primary focal segmental glomerulosclerosis (FSGS) is a rare glomerulopathy associated with nephrotic range proteinuria (>3.5 g/24 h). Treatment goals are reduction in proteinuria, which can delay progression to end-stage renal disease. Lack of (...)
02:00
MO230: De Novo Double Glomerulopathy (Membranous Nephropathy, Mn and Collapsing Focal Segmental Glomerulosclerosis, CFSGS) Associated to Positive Myeloperoxidase-O (MPO) Antibody Following Pfizer-Biontech MRNA Vaccination Covid 19 - Marega A, Pizzolitto S, Pian M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIn the COVID 19 pandemic era, anti SARS-CoV-2 vaccination showed high efficacy at preventing the infection and its most severe complications. The aim of this report is to describe an unusual double glomerulopathy related to anti SARS-CoV-2 vaccination and the good (...)
02:00
MO231: Comparison of Dominant and Non-Dominant C3 Deposition in Primary Glomerulonephritis - Ryu J, Jun Chin H. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAlternative complement pathway (AP) dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and non-dominant (...)
02:00
MO232: Amyloidosis AL in Nephrology - Najla D, Faten G, Ikram A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSystemic AL amyloidosis is a rare pathology associated with the precipitation of monoclonal immunoglobulin light chains in the form of fibrils in various organs. Clinical presentations are extremely variable and diagnosis is often delayed. The two most affected organs (...)
02:00
MO233: Real-World Signs and Symptoms at Diagnosis in Patients With IGA Nephropathy - Roccatello D, Kattlun J, Przybysz R, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSImmunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, with an estimated annual incidence of 25 per million. Patients with persistent proteinuria ? 1 g/day are at increased risk of disease progression, with 30% or more (...)
02:00
MO268: Use of Corticosteroids in a Norwegian Cohort of Patients with IGA Nephropathy and Rapid Progression to End-Stage Renal Disease - Lunde Haaskjold Y, Rivedal M, Gjærde Lura N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSDespite several clinical trials, treatment with corticosteroids in patients with Immunoglobulin A nephropathy (IgAN) remains controversial [1, 2]. The recently updated KDIGO guidelines suggests that treatment with corticosteroids could be considered in patients with (...)
02:00
MO269: The Frequency and Aetiology of Repeated Acute Kidney Injury Episodes Determines the Degree of Renal Damage - Mercado-Hernandez J, Fuentes-Calvo I, Sancho Martinez S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is the most serious health problem and constitutes the 16th leading cause of death worldwide. Multiple studies have identified acute kidney injury (AKI) as a risk factor for the development and progression of CKD [1]. Despite extensive (...)
02:00
MO270: N-3-Oxododecanoyl Homoserine Lactone Inhibits Angiogenesis by Activating the Angiopoietin-Tie System in Human Endothelial Cells - Shin J, Hee Ahn S, Hyun Kim S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe dysregulation of the angiopoietin–Tie system is associated with the development of sepsis-associated endothelial dysfunction. Bacterial quorum-sensing molecules act as pathogen-associated molecular patterns; however, the effect of quorum-sensing molecules on the (...)
02:00
MO271: A Single Dose of Lithium Protects Against Renal Injury Following Bilateral Ureteral Obstruction - Heloisa Massola Shimizu M, Aparecido Volpini R, Carolina de Braganca A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSObstructive nephropathy decreases renal blood flow (RBF) and glomerular filtration rate (GFR). Glycogen synthase kinase 3? (GSK3 ?), an apoptotic enzyme, is increased in a model of unilateral obstruction. Treatment with a single dose of lithium, a selective inhibitor of (...)
02:00
MO062: Pan-Disease Segmentation and Feature Extraction for Large-Scale Digital Nephropathology - Hölscher D, Bouteldja N, Lan Y, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSNephropathology is essential for the diagnosis of kidney diseases. Deep learning-based image analyses, including segmentation of kidney histology, open new possibilities for reproducible quantitative precision pathology. Current segmentation approaches in kidney (...)
02:00
MO224: Antibody Responses to a 3RD Booster Dose of SARS-COV-2 Vaccines in Patients with Vasculitides and Renal Involvement - Chalkia A, Koutsianas C, Alexakou Z, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSImmunosuppressed patients are in general less likely to achieve a detectable antibody response to SARS-CoV-2 after the primary doses of vaccine administration. However, there are limited data for the effect of a third booster dose in this patient population, (...)
02:00
MO225: A Past Medical History of Autoimmune Disease Predicts a Future With Fewer Relapses in Patients With ANCA Vasculitis - Lionaki S, Marinaki S, Fragkioudaki S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSTo explore the frequency and impact of an autoimmune disease past-medical history (PMH) in the clinical picture and outcomes of patients with ANCA-associated vasculitis (AAV).METHODThis is a retrospective study of patients with biopsy-proven AAV, >16 years old, with (...)
02:00
MO207: A Phase 1/2, Multicenter Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BION-1301 in Healthy Volunteers and Adults with IGA Nephropathy - Barratt J, Schwartz B, Sorensen B, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSImmunoglobulin A nephropathy (IgAN) is the leading cause of primary glomerulonephritis worldwide with limited treatment options, especially for high-risk patients [1]. BION-1301 is a novel humanized monoclonal antibody that blocks a proliferation-inducing ligand (...)
02:00
MO220: Comparison of the Effects of Hydroxychloroquine and Glucocorticosteroids on Immunological Parametrs in Patients with IGA Nephropathy - Komissarov K, Nizheharodava D, Pilotovich VV, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCurrent treatment strategies of IgA nephropathy (IgAN) primarily involve blood pressure control, renin–angiotensin–aldosterone system inhibitors (RAASIs), and glucocorticosteroids (GCs), which are recommended when the supporting therapies fail to reduce proteinuria (PU) (...)
02:00
MO221: Glomerulopathies After COVID-19 Vaccination. Report of Cases in Our Centre - Perea-Ortega L, Polo Criado C, Hidalgo Guzman P, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAfter the start of the vaccination campaign against the SARS-COV-2 pandemic, it is possible that the number of cases of de novo and relapsing glomerulopathies will increase.So far, most of the publications related to post-vaccination minimal change disease (also (...)
02:00
MO222: Prognostic Factors for CKD Progression in Patients with IGA Nephropathy - Kostopoulou M, Fokas S, Drakopoulos A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIgA nephropathy is a progressive renal disease with up to 30% of patients reaching end stage kidney disease within 10–20 years. The aim of this study was to analyze the phenotype of patients with IgA nephropathy followed in a tertiary renal center and explore its (...)
02:00
MO223: Contribution of Interstitial CD138 + Plasma Cells on the Renal Outcome in Patients with Anca-Associated Vasculitis - Odler B, Haefner J, Pollheimer M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPlasma cells (PC) are the most differentiated antibody and cytokine-producing B lineage cells and are thought to contribute to the perpetuation of inflammation in patients with ANCA-associated vasculitis (AAV). Agents targeting PCs are of interest in AAV, however, (...)
02:00
MO256: IGM in Fibrillary Glomerulopathy Linked to Monoclonal Gammopathy - Fayos de Arizón L, Mercedes Diaz Encarnacion M, Arce Y, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSFibrillary glomerulopathy (FGN) is a rare glomerular deposit disease accounting for less than 1% of annual native kidney biopsies. Its pathogenesis is still not fully understood. Immunofluorescence (IF) techniques in the vast majority of cases reveal the presence of (...)
02:00
MO257: Glucocorticoid Dosing in Induction Remission Treatments for ANCA-Associated Vasculitis - Floyd L, Morris A, Shetty A, et al. Nephrol Dial Transplant

AbstractBACKGROUNDAnti-neutrophil cytoplasm antibodies (ANCA) associated vasculitis (AAV) is a rare and complex autoimmune disease. Induction remission and maintenance treatment typically includes glucocorticoids (GC) in addition to other immunosuppressive medications. Recent trials such as (...)
02:00
MO258: Urinary Single-Cell Sequence Analyzes the Urinary Macrophage in Different Outcomes of Membranous Nephropathy - Liu X, Zhao Y, Niu Y, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSGreat progresses have been made in the diagnosis and treatment of membranous nephropathy (MN), but some patients still do not respond to the treatment. We performed single-cell sequencing to analyze the urine cells of patients with and without complete remission of (...)
02:00
MO259: Maintenance Therapies for Anti-Neutrophil Cytoplasmic Antibody Small-Vessel Vasculitis: A Network Meta-Analysis - Bellos I, Boletis I, Karagiannis M, et al. Nephrol Dial Transplant

AbstractBACKGROUNDS AND AIMSOver the past two decades, considerable progress has been made in maintaining remission in patients with anti-neutrophil cytoplasmic antibody (ANCA) vasculitis using a variety of medications, including rituximab, azathioprine, mycophenolate, methotrexate, and (...)
02:00
MO208: De Novo Glomerulonephritides Following BNT162B2 COVID-19 Vaccine: A Case Series - Fornara L, Musetti C, Guglielmetti G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe development and massive use of mRNA COVID-19 vaccine BNT162b2 has raised new concerns on triggering de novo immune-mediated diseases, in particular rare diseases as glomerulonephritis (GN), even if the security profile is excellent and severe reactions have been (...)
02:00
MO209: Baseline Characteristics of Adults Enrolled in the Ongoing Phase 3 Randomized, Double-Blind, Active-Control Trial of Sparsentan For the Treatment of Immunoglobulin A Nephropathy (PROTECT) - Wong M, Barratt J, Komers R, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSImmunoglobulin A nephropathy (IgAN) is the most common glomerular disease worldwide. Despite optimized standard of care treatment, up to 40% of individuals with IgAN develop kidney failure requiring dialysis or kidney transplantation, consequently seriously affecting (...)
02:00
MO060: HIF1? and Succinate Pathway: Role in Deceased Kidney Donors Inflammation - Guillén-Gómez E, Vilardell J, Silva I, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe type of donor has an important impact on the renal prognosis of the recipient. Thus, it has been observed that the decline of renal function is higher in deceased donor (DD) than those observed in living donors (LD). These could be related with the (...)
02:00
MO210: Anti-Receptor Type M Antibodies of Phospholipase A2 in the Diagnosis of Primary Membrane Nephropathy - Daniel Diaz Garcia J. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIdiopathic membranous nephropathy (IMN) is one of the main causes of nephrotic syndrome in the adult population. Approximately between 20% and 40% of patients who suffer from it require replacement therapy in a period of 10–15 years. Recently, it has been reported that (...)
02:00
MO075: Decline of Regenerative Capacity of Renal Progenitors and Progressive Polyploidization of Tubular Cells Contribute to Kidney Physiologic Response During Aging - Antonelli G, Conte C, De Chiara L, et al. Nephrol Dial Transplant

AbstractBACKGROUNDThe biological process of renal aging is characterized by progressive structural and functional deterioration of the kidney leading to end-stage renal disease in elderly patients. Renal aging includes a complex network of cellular signaling stress such as senescence, (...)
02:00
MO076: GLUT2 as a Key Factor in the Pathogenesis of Diabetic Kidney Disease - Ahmad M, Hinden L, Hamad S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSDiabetic kidney disease (DKD) affects more than 30% of all diabetic patients. It is strongly associated with increased morbidity, mortality and global healthcare burden. Furthermore, it is considered the primary cause of end-stage kidney disease (ESKD). The renal (...)
02:00
MO212: Updated Interim Results of A Phase 1/2 Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Activity of BION-1301 in Patients With IGA Nephropathy - Barratt J, Kooienga L, Hour B, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSImmunoglobulin A nephropathy (IgAN) is the leading cause of primary glomerulonephritis worldwide with limited treatment options, especially for high-risk patients [1]. BION-1301 is a novel humanized monoclonal antibody that blocks a proliferation-inducing ligand (...)
02:00
MO213: Sars-COV-2 Vaccination DID Not Affect the Clinical Course of IGA Nephropathy in Latvian Adult Cohort - R?cenis K, Jana Saul?te A, Popova A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe current strategy to fight against the COVID-19 pandemic involves active patient vaccination. Patients with renal and autoimmune diseases are in high risk for severe COVID-19 infection [1]. Therefore they should be prioritized for vaccination. Immunoglobulin A (...)
02:00
MO234: Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Antibody Production in Nephrotic Syndrome - Chebotareva N, Vinogradov A, Cao W. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRecently, evidence has emerged that the ubiquitin system, which is involved in extracellular protein degradation, is most susceptible to damage in podocytes in cases of severe nephritis. We studied anti-ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) antibodies in (...)
02:00
MO235: TGF-?1/PSMAD3 Dependent Signaling in Glomerulonephritis and Its Association With Renal Injury and Progression - Chalkia A, Gakiopoulou H, Giannou P, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSTransforming growth factor-?1 (TGF-?1) has long been considered as a potent, multifunctional cytokine that is involved in the pathogenesis of fibrosis and inflammation, which acts through Smad signaling in renal pathology. We intended to investigate the expression of (...)
02:00
MO236: Serological Markers of Celiac Disease in Patients With IGA-Nephropathy: Prevalence and Diagnostic Significance - Mantsaeva M, Borisov A, Stremoukhov A. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIt is known that IgA-nephropathy (IgAN) can be secondary to liver disease, skin disease, lung disease, etc. There is also evidence of an association between IgAN and celiac disease. In the Russian population, there are no studies aimed at identifying the prevalence of (...)
02:00
MO237: Rituximab in Treatment of Minimal Change Disease and Primary Focal Segmental Glomerulosclerosis in Adults-Single Center Experience - Zagorec N, Horvatic I, Kasumovi? D, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRituximab (RTX) showed some efficacy in treatment of minimal change disease (MCD) and primary focal segmental glomerulosclerosis (pFSGS) [1]. The results of its off-label use and as steroid-sparing agent were especially promising in steroid-dependent, frequently (...)
02:00
MO284: Dipeptidyl-Peptidase-4 Inhibitor, Teneligliptin, Ameliorates Folic Acid-Induced Acute Kidney Injury in Mice - Ema C, Iwakura T, Tsuchida M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is histologically characterized by tubular cell death and inflammation. It has demonstrated that cell death in renal tubule cells on AKI could be introduced by regulated necrosis or apoptosis, but the molecular mechanisms are reported to be (...)
02:00
MO285: FOSL1 Preserves Klotho Expression and Limits Acute Kidney Injury - Cuarental L, Ignacia Ceballos Darnaude M, Valino L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSFosl1 (FRA1, Fos-related-antigen 1) is a transcription factor of the AP-1 complex (activator protein 1) that regulates the expression of genes that regulates processes involved in acute kidney injury (AKI) such differentiation, inflammation, proliferation and cell (...)
02:00
MO286: MIR-155 Deficiency Protects Renal Tubular Epithelial Cells from Telomeres and Genomic DNA Damage in Cisplatin-Induced Acute Kidney Injury - Yin Q, Wang B, Liu B. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCisplatin nephrotoxicity is an important cause of acute kidney injury (AKI), limiting cisplatin application in cancer therapy. Growing evidence had suggested that genome instability, telomere dysfunction and DNA damage were involved in the tubular epithelial cells (...)
02:00
MO287: A Recombinant BIO-HDL (CER-001) Can Prevent SARS-COV2-Induced Renal Dysfunction by Restoring SR-BI Signalling - Franzin R, Stasi A, Fiorentino M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSReplication of the enveloped SARS-COV2 virus can alter lipidomic composition and metabolism of infected cells [1]. These alterations commonly result in a decline in HDL, total cholesterol and LDL, and an increase in triglyceride levels in COVID-19 patients. (...)
02:00
MO039: Multidisciplinary approach improves genetic diagnosis of Alport syndrome in the next-generation sequencing ERA - Galan Carrillo I, Galbis L, Martínez Jiménez V, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAlport Syndrome (AS; ORPHA 63) is one of the most frequent hereditary kidney diseases (HKD), caused by COL4A5 mutations in X-linked AS (XLAS) and COL4A3-4 mutations in the autosomal forms, dominant (ADAS) and recessive (ARAS). Definitive diagnosis of AS is essential (...)
02:00
MO248: A Renal Biopsy Might be a Mandatory Procedure in Patients with Hypertension and Decreased Renal Function Despite Normal Urinalysis Findings - Hee Cho W, Cho B, Min Jung S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe most common cause of the end-stage renal disease is diabetes and hypertension. However, most centers do not try to find the cause of hypertension in patients with early-stage CKD but give antihypertensive medicine because most centers regard the cause as essential (...)
02:00
MO249: Characteristics of Glomerulonephritis (GN) with Dominant C1Q Precipitation Compared to Corresponding GN without C1Q Staining on Immunofluorescent Examination - Jun Chin H, Ryu J, Young Na K. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAlthough C1q nephropathy (C1QN) was introduced three decades ago, the clinical significance and renal outcomes of C1QN remain unclear. Furthermore, it is uncertain whether the diagnosis of C1QN could be a new pathologic entity with clinical meanings. This study aimed (...)
02:00
MO250: COVID-19 Associated Collapsing Variant of Focal Segmental Glomerulosclerosis: A Case Series of 7 Patients from a Single UK Centre - Peracha J, Shah R, Neil D, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCases of collapsing glomerulopathy in association with COVID-19 infection have been reported worldwide, frequently referred to as COVAN (COVID-19 Associated Nephropathy). Affected patients are almost exclusively of Black ethnicity, likely associated with APOL-1 renal (...)
02:00
MO251: Renal Glucocorticoid Receptor Expression and Clinical Course in Patients with IGA Nephropathy - Tekin Ala B, Paydas S, Kaya B, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSGlucocorticoids are used as primary treatment in IgA nephropathy (IgAN), and they manifest their effects by binding to intracellular glucocorticoid receptors. Studies have shown that GCR expression correlates with the degree of steroid response in various diseases. (...)
02:00
MO288: Kidney Tubule Polyploidization Preserves Residual Kidney Function and Assures Survival During Acute Kidney Injury - De Chiara L, Lazzeri E, Romagnani P. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute Kidney Injury (AKI) is characterized by a rapid deterioration of kidney function. Recently, we showed that tubular epithelial cells (TC) respond to AKI by triggering polyploidy, a condition in which a normally diploid cell acquires additional sets of (...)
02:00
MO289: IL33 Exerts Toxicity in the Heart as Secreted by Renal Inflammation - Florens N, Kasam R, Rudman Melnick V, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a major cardiovascular risk factor, regardless of the severity or the origin of the AKI. Among this risk, AKI imparts an array of signals and long-term physiologic alterations that can precipitate heart insufficiency and hypertrophy. (...)
02:00
MO290: Inhibition of the KDM4C and JMJD3 Histone Demethylases Alleviates the Tubular Renal Damage Triggered by Endoplasmic Reticulum Stress - Diaz-Ulnes P, Laura Saiz Alvarez M, Corte V, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAlterations in protein homeostasis in tubular cells lead to endoplasmic reticulum (ER) stress activating the unfolded protein response (UPR) pathway, which contributes to repair or aggravate the renal damage [1]. This pathway is initiated by three major protein (...)
02:00
MO071: Hemolysis is Associated with Altered Heparan Sulfate of Endothelial Glycocalyx And with Local Complement Activation in Thrombotic Microangiopathies - Laboux T, Maanaoui M, Allain F, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe complement system plays a key role in the pathophysiology of renal thrombotic microangiopathies (TMA), as illustrated by atypical hemolytic uremic syndrome (HUS) characterized by a high rate of mutations in complement proteins. However, complement abnormalities (...)
02:00
MO072: PST3.1A, An Inhibitor of MGAT5 Decreases Renal Fibrosis in a Rat Model of Chronic Kidney Disease - Muyor K, Laget J, Duranton F, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRenal fibrosis is a main feature of chronic kidney disease (CKD) that participates in its progression to the end stage.(1) N-acetylglucosaminyltransferase 5 (MGAT5) adds N-acetylglucosamines to newly synthesized glycoproteins and is overexpressed in tumors (...)
02:00
MO204: IGA Nephropathy: FACTORS that Influence Renal Survival and Progression to End-Stage Renal Disease - Luisa Correia A, Carolina Pimenta A, Pinto H, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and an important cause of kidney failure requiring kidney replacement therapy [1]. Given that IgAN has no specific treatment and the options available are often associated with (...)
02:00
MO205: The Outcome of Patients Without Nephrotic Syndrome (NS) is Not Different From Patients With NS, WHO Were Diagnosed as Minimal Change Lesion - Yun G, Eun Son H, Jun Chin H. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMinimal change lesion (MCD) accounts for 10–15% of adult patients with nephrotic syndrome and is characterized by edema, nephrotic-ranged proteinuria (NP) and pathologic findings of nearly normal appearance of glomeruli on light microscopy, minimal staining of (...)
02:00
MO216: The Importance of Nephrotic Range Proteinuria in Renal Survival of Patients With IGA Nephropathy - Fokas S, Kostopoulou M, Kanellopoulou K, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPersistent proteinuria (urinary protein level [UPr]>1 g/24 h) and especially nephrotic range proteinuria, is a poor prognostic factor in IgA nephropathy. Patients with proteinuria > 3.5 g/24 h have a 24-fold faster decline of renal function as compared with those with (...)
02:00
MO217: Proteinuria/BMI Ratio in Primary Membranous Nephropathy as a Possible Predictive Factor of Therapeutic Efficacy - Siligato R, Gembillo G, Calabrese V, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe attempt to identify the most suitable therapies and their appropriate dose is at the base of tailored medicine approach. We decided to analyze the renal outcomes of patients affected by primary membranous nephropathy (MN) referring to our unit from January 2005 to (...)
02:00
MO218: Anca-Associated Vasculitis After SARS-COV-2 Vaccination in a Patient With HLA-DRB1*09: 01 ALLELE: A Case Report and Literature Review - Kawamura T, Nakazawa D, Komatsumoto M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSA Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents with severe pneumonia and fatal systemic complications. Currently, SARS-CoV-2 vaccines are effective in reducing the risk of onset and severity of (...)
02:00
MO219: Are C4D, Nephr?n and WT1 Express?ons ?mportant ?n the D?fferent?al D?agnos?s between Focal Segmental Glomeruloscleros?s and M?n?mal Change D?sease? - Akcali E, Turgutalp K, Yuyucu Karabulut Y, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSFocal Segmental Glomerulosclerosis (FSGS) and Minimal Change Disease (MCD) are most common seen glomerulonephritis. Differential diagnosis between FSGS and MCD by light microscopy (LM) cannot be made in some times. In this situation, electron microscopy (EM) is needed (...)
02:00
MO264: Selective Endothelin a Receptor Antagonist Atrasentan Attenuates Mesangial Cell Injury, Proteinuria and intra-renal proliferative, inflammatory and Fibrotic Transcriptional Networks in a Rat Model of Mesangioproliferative Glomerulonephritis - Olson E, Mcconnell M, Ragan S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMesangial cell (MC) activation, characterized by excess proliferation and extra-cellular matrix deposition is the initiating intra-renal event in the pathogenesis of mesangioproliferative glomerulonephritis (MPGN), including IgA nephropathy (IgAN). However, the (...)
02:00
MO265: Patients with Alport Syndrome from the Radar Registry: A Natural History Study - Liu S, Lin J, Pitcher D, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAlport Syndrome (AS) is the second most common genetic kidney disease and results from mutations in COL4A3, A4 or A5 genes. It is characterized by glomerulonephritis, CKD, hearing loss, and ocular lens defects. Estimated incidence is ? 1 in 50 000 live births with (...)
02:00
MO266: Deficiency of Urokinase-Type Plasminogen Activator Exacerbates CBSA-Induced Membranous Nephropathy in Mice - Jao T, Guo C, Bai C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIn nondiabetic population, primary membranous nephropathy (PMN) is the most common cause of idiopathic nephrotic syndrome in the world. Urokinase-type plasminogen activator (uPA) is one of the key members of fibrinolysis system, which functions as dissolving blood (...)
02:00
MO267: Traditional and Disease-Related Cardiovascular Risk Factors in Anca-Associated Vasculitis: A Prospective, Two-Centre, Observational Cohort Study - Vegting Y, Lars Penne E, Hilhorst M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSANCA-associated vasculitis (AAV) has been associated with increased risk of cardiovascular (CV) events. The purpose of the present study was to asses cardiovascular risk determinants and outcomes in a two-centre prospective cohort of AAV patients.METHODPrevalent (...)
02:00
MO051: Single-Cell Transcriptomics of Lupus Nephritis with ANCA Positive - Meng T, Lin W, Ooi J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSLupus nephritis (LN) is one of the most common complications of SLE that can lead to worsened kidney function or renal failure. Antineutrophil cytoplasmic antibodies (ANCA) are autoantibodies that are against antigens in the cytoplasm of neutrophils and monocytes and (...)
02:00
MO052: New Trend in the Diagnosis of Kidney Disease in Cancer Patients: A Multicenter Study - Bolufer M, Garcia Carro C, Blasco M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe new advances in cancer treatments and the increasing prevalence of kidney disease in the population with cancer have extended the indication of kidney biopsies. The purpose of the study is to analyze clinical and histological characteristics of patients with (...)
02:00
MO073: Ex Vivo C5B9 Deposition Test as a Diagnostic and Monitoring Tool For Primary and Transplantation Associated AHUS - Jacobs Cachá C, Martín-Agramunt M, Gema Ariceta Iraola M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe atypical hemolytic uremic syndrome (aHUS) is a complement-mediated (CM) ultrarare disease that manifests as thrombotic microangiopathy (TMA) with preferential small kidney vessels involvement. aHUS is caused by genetic or acquired deregulation of complement (C’) (...)
02:00
MO074: SGLT2 Inhibition Promotes Intrinsic Kidney Regeneration by Cells of the Renin Lineage - van der Pluijm L, Koudijs A, Stam W, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSWith chronic kidney disease (CKD) prevalence rapidly increasing, the need for novel therapies is rising. Sodium glucose co-transporter-2 (SGLT2) inhibitors were originally developed to treat hyperglycemia in patients with type 2 diabetes mellitus. Clinical trials with (...)
02:00
MO226: Is Remission of Hematuria Associated with Kidney Outcome in Biopsy-Proven Primary IGA Nephropathy? - Popa O, Stefan G, Petre N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMicroscopic hematuria, associated with variable proteinuria, is the most common clinical feature of IgA nephropathy (IgAN). However, its role in the disease progression is still controversial. This study aims to assess whether remission of hematuria is associated with (...)
02:00
MO227: Anca-Associated Vasculitis Following Pfizer-Biontech COVID-19 Vaccine: True Association or Circumstantial? - Marouço C, Carvalho D, Magriço R, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAntineutrophil cytoplasmatic antibody (ANCA) associated vasculitis (AAV) is a small vessel vasculitis hallmarked by the presence of antibodies against antigens in cytoplasmic granules of neutrophils. Vaccines per se stimulate the immune system, including the innate (...)
02:00
MO228: Clinical Features and Obesity Impact on Chronic Kidney Disease Progression in Patients with Glomerular Diseases - Jordanova E, Jankovic R, Pantic I, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe kidney disease secondary to obesity is obesity-related glomerulopathy characterized by the following: glomerulomegalia, progressive glomerulosclerosis, proteinuria and progression of renal failure. The aims of the present study were to evaluate the clinical (...)
02:00
MO229: Is Nodular Glomerulosclerosis Always Associated with Diabetic Nephropathy? - Nabil H, Chettati M, Fadili W, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSNodular glomerulosclerosis (NGS) is a histological diagnosis that can be found in several etiologies. It corresponds to a particular form of expansion of the extracellular matrix within the mesangium.Glomerulosclerosis is not very specific, its nodular form is on the (...)
02:00
MO280: Osteoblast-Specific Deletion of MEMO1 in Mice Severely Impairs the Expression of FGF23 - Moor M, Bartos K. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMemo deletion in mice caused a bone disease with diminished osteoblast and osteoclast biomarkers in serum [1], resembling the alterations occurring in adynamic bone disease in humans with renal failure, as well as those found in Klotho-deficient mice [2]. In addition, (...)
02:00
MO281: Development of an Experimental Model of Haemodynamic Frailty Predisposing to Acute Kidney Injury - Diaz-Morales N, Sancho Martinez S, Fuentes-Calvo I, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSFrailty is a pre-morbid condition characterized by physiological decline and reduced physiological reserve leading to increased vulnerability to disease, especially common among older adults. Tissue and organ function is underpinned by effective haemodynamic (...)
02:00
MO282: Sigma-1 Receptor Agonists are Protective in Renal Ischemia/Reperfusion Injury - Roland Toth A, Lakat T, Hodrea J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRenal ischemia/reperfusion injury (IRI)-induced acute kidney injury is associated with high mortality and morbidity and effective therapies are lacking. We previously showed that Sigma-1 receptor (S1R) agonist fluvoxamine treatment is protective against renal IRI (...)
02:00
MO283: A Novel Hemoperfusion Adsorbent for Selective Removal of Circulating Histones in Septic Blood - LI Y, Song T, Jiang L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCirculating histones play a crucial role in the development and progression of sepsis and is associated with high mortality. Hemadsorption with the CytoSorb® filter has been shown to non-specifically eliminate systemic circulating histones in plasma from injured (...)
02:00
MO031: Long-term safety of treatment with tolvaptan in patients with autosomal dominant polycystic kidney disease - Martins Muñoz J, Espinel L, De Lorenzo A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSTolvaptan, a vasopressin antagonist, is a drug that acts by slowing the progression of autosomal dominant polycystic kidney disease (ADPKD). Its administration is not free of side effects. To assess the long-term safety profile of ADPKD patients treated with (...)
02:00
MO049: Correlation of Findings in Urinary Sediment Microscopy and Histological Lesions in Kidney Biopsy: Red Flags Not to be Missed - Barata R, Navarro D, Moreira Fonseca N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSUrinary sediment (U-Sed) is a noninvasive laboratory test that can be performed by an automated analyzer or manually by trained personnel. Manual U-Sed remains the diagnostic standard because it excels at distinguishing isomorphic from dysmorphic red blood cells, (...)
02:00
MO050: The First Report from the National COVID-19 Autopsy Registry in Germany - von Stillfried S, David Bülow R, Röhrig R, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAutopsies are an invaluable tool in medicine for studying the pathophysiology of diseases, including kidney diseases and causes of death. To facilitate multicenter autopsy-based studies and to provide a single point of contact for data analysis and reporting, the (...)
02:00
MO061: Mri-Based Segmentation of Kidneys in Participants of the German National Cohort (NAKO/GNC) Study - Kellner E, Lipovsek J, Reisert M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) affects around 10% of adults worldwide and an estimated 13–17% in Germany1. Imaging is a novel, promising approach to identify additional markers of kidney function and CKD2. Within a large, population-based cohort study, the German (...)
02:00
MO022: Digenic inheritance in Alport syndrome - del Mar Del Águila García M, Poyatos Andújar A, Isabel Morales García A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe approach to Alport syndrome is a difficult task due to the phenotypic variability of its symptomatology, incomplete penetrance and its different forms of inheritance [1].It presents a high degree of underdiagnosis, both because of erratic diagnosis as well as the (...)
02:00
MO244: PCSK9 Inhibitors are Efficient in Treatment of Resistant Hypercholesterolemia in Nephrotic Syndrome - Vukovic Brinar I, Ivandic E, Gellineo L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSHypercholesterolemia in nephrotic syndrome is commonly resistant to statin therapy and represents an important clinical challenge both for cardiovascular risk prevention and to eliminate lipotoxic effect on podocytes. Serum PCSK9 level is elevated in nephrotic (...)
02:00
MO245: Risk Factors for Venous Thrombosis in ANTI-PLA2R + VE AND?VE Primary Membranous Nephropathy: A 6-YEAR Retrospective Analysis - Lin Henry Wu H, Alozai A, Wing Ching LI J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSVenous thrombosis (VT) is an established cause of increased morbidity and mortality amongst patients with nephrotic syndrome. Previous studies suggest primary membranous nephropathy (PMN) to be associated with the highest risk of developing VT amongst all nephrotic (...)
02:00
MO246: Belimumab Disrupts Memory B Cell Trafficking in Patients with Systemic Lupus Erythematosus - Arends E, Zlei M, Tipton C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSBelimumab (BEL), a recombinant human monoclonal antibody directed against B-cell activating factor (BAFF), is the first approved biological agent for patients with systemic lupus erythematosus (SLE) and a high level of disease activity or lupus nephritis (LN). BEL (...)
02:00
MO011: The Use of a 4-Point Scoring Scale in 18F-FDG-PET/CT Imaging Helps for Diagnosis of Renal and Hepatic CYST Infections in Patients with Autosomal Dominant Polycystic Kidney Disease: A Validation Cohort - Demuynck S, Lovinfosse P, Seidel L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAutosomal dominant polycystic kidney disease (ADPKD) is prone to multiple complications, including cyst infection (CyI). 18F-FDG PET/CT imaging proved useful in the diagnosis of renal and hepatic CyI. A 4-point scale comparing the uptake of 18F-FDG in the suspected (...)
02:00
MO006: Identifying the Main Predictors of Urine Output in Autosomal Dominant Polycystic Kidney Disease (ADPKD) Patients taking Tolvaptan - Borrego-Utiel F, Isabel Morales García A, Polo Moyano A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSTolvaptan (TVP) blocks vasopressin V2 receptors causing severe polyuria. Few works have analyzed factors associated with urine output in autosomal dominant polycystic kidney disease (ADPKD) patients taking TVP.METHODWe selected 24 h urine samples from ADPKD patients (...)
02:00
MO021: Alport syndrome manifestation in twins - Navickaite M, Janonyt? K, Cerkauskiene R, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAlport syndrome (AS) is a hereditary renal disease characterized by progressive loss of kidney function and often accompanied by sensorineural hearing loss and ocular abnormalities [1]. The variety of symptoms and their severity is closely associated with mode of (...)
02:00
MO027: Clinical efficacy of treatment with tolvaptan in patients with autosomal dominant polycystic kidney disease - Martins Muñoz J, Tarragon B, De Lorenzo A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAutosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. The only treatment approved today to slow its progression is tolvaptan (vasopressin antagonist). However, there is no clinical efficacy parameter for follow-up during (...)
02:00
MO036: Detection of copy number variations by single-nucleotide-polymorphism array in patients with end-stage renal disease of unknown etiology - Granhøj J, Venborg Pedersen K, Birn H, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSEstablishing the genetic basis of renal disease is pivotal to improve diagnostic and treatment strategies. Pathogenic copy number variations (CNVs) caused by chromosomal imbalances contribute significantly to the pediatric renal disease burden, especially in children (...)
02:00
MO037: Burosumab in adult patients with X-linked hyphophosphatemic rickets: an Italian Experience - Edvige Foligno N, Arcidiacono T, Bologna A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSX-linked hypophosphoremic rickets (XLH) is a rare disease caused by mutations in the PHEX gene leading to an increase in the serum levels of FGF23, which inhibits the tubular reabsorption of phosphates and the production of 1,25(OH)2D. These alterations cause (...)
02:00
MO055: Multi-Class Segmentation of Kidney Tissues using Convolutional Neuronal Networks (CNNS) - Schmitz J, Christensen D, Müller L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRoutine pathological diagnostics in kidneys are mainly based on semi-quantitative eyeballing. In own former studies, we showed predictive value of precise immune cell quantification in allografts using digital semi-automated techniques. We now aim to achieve fully (...)
02:00
MO056: Alteration of Glycocalyx on Endothelium of Peritubular Capillaries in CKD - Ermert K, Mara Klinkhammer B, Miriam Buhl E, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe glycocalyx is a carbohydrate-rich gel-like mesh, which covers the luminal surface of cells, including the endothelium. The glycocalyx is involved in many regulatory functions of the endothelium, including vascular permeability. In chronic kidney disease (CKD), (...)
02:00
MO063: A New Tool for Preclinical Research and Drug Discovery: Extracellular Matrix Remodeling Quantification in Human Precision-Cut Kidney Slices - Louise Møller A, Rasmussen D, Jensen M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAccumulation of extracellular matrix (ECM) proteins is a hallmark of renal fibrosis, leading to altered tissue homeostasis, kidney failure and ultimately death. Current treatment strategies are ineffective in halting renal fibrogenesis, and drug discovery is hampered (...)
02:00
MO064: Expression Studies on Magi2 in Different FSGS Models - Hay E, Siegerist F, Schindler M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMAGI2 is a tight junction protein and member of the membrane-associated guanylate kinase (MAGUK) family. In the glomerulus, it is exclusively expressed in podocytes and interacts with the slit diaphragm protein nephrin. Recent studies and podocyte-specific MAGI2 (...)
02:00
MO096: Chronic Liver Disease and Hepatic Calcium-Oxalate Deposition in Patients with Primary Hyperoxaluria Type I - Recker P, Beck B, Sikora P, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPatients with primary hyperoxaluria type I (PH I) are prone to develop early end-stage kidney failure (ESKF). Systemic deposition of calcium-oxalate (CaOx) crystals starts when renal function declines and plasma oxalate (Pox) increases >30 µmol/L. It is anticipated (...)
02:00
MO097: Idiopathic Hypercalciuria: Calciuria and Citraturia Evolution. A 20-year Longitudinal Study - Maria Barrera Herrera A, Pérez Suárez G, Isabel Luis Yanez M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSReduction and normalization of calciuria in children with idiopathic hypercalciuria (IH) was published by Aladjem et al. (1996). The association between IH and hypocitraturia was described in two Brazilian studies; however, further studies are needed to determinate (...)
02:00
MO202: Pulmonary-Renal Syndrome in Patient with Chronic Hepatitis C And HIV Disease - Šerš?ova N, Saul?te M, Kuzema V, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPulmonary-renal syndrome (PRS) is characterized by rapidly progressive glomerulonephritis and lung vasculitis. Most common causes of PRS are Goodpasture's disease, antineutrophil cytoplasm antibody (ANCA) associated vasculitis and systemic lupus erythematosus; rarely (...)
02:00
MO203: Minimal Change Disease Secondary to SARS-COV-2 (COVID-19) Infection: A Report of 2 Cases and Review of Related Literature - Michael Pasilan R, Russell Villanueva A, Anne Manalili S. Nephrol Dial Transplant

Abstract>BACKGROUND AND AIMSThe COVID-19 pandemic has brought to the forefront a wide spectrum of renal injuries that included glomerulopathies, some of which were recently highlighted in various case reports. These consist of focal and segmental glomerulosclerosis (FSGS) and minimal change (...)
02:00
MO260: Prognostic Role of Electron Microscopy Lesions in IGA Nephropathy - Stefan G, Terinte-Balcan G, Stancu S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe progression of immunoglobulin A nephropathy (IgAN) is currently assessed using the Oxford MEST-C score, which uses five indicators (mesangial and endocapillary hypercellularity, segmental sclerosis, interstitial fibrosis/tubular atrophy and the presence of (...)
02:00
MO261: Sparsentan, The Dual Endothelin Angiotensin Receptor Antagonist (DEARA), Attenuates Albuminuria and Protects from the Development of Renal Injury to a Greater Extent Than Losartan in the GDDY Mouse Model of IGA Nephropathy: A 16-Week Study - Nagasawa H, Suzuki H, Jenkinson C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSgddY mice are an IgA nephropathy (IgAN)-prone mouse model that develops albuminuria by 8 weeks (wks) of age with glomerular IgA, IgG and C3 deposits and progressive mesangioproliferative glomerulonephritis. We have previously shown that sparsentan (SP), a novel, (...)
02:00
MO262: Intravenous Cyclophosphamide for High-Risk Primary PLA2R-Positive Membranous Nephropathy - Stefan G, Stancu S, Dorin Zugravu A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe mainstay of treatment for high-risk primary membranous nephropathy (MN) is the cyclic steroid-oral cyclophosphamide (CYC) regimen (modified Ponticelli regimen). However, there has been increasing awareness of serious treatment-related toxicity. Intravenous CYC (...)
02:00
MO263: Multi-Antibody Composition in Lupus Nephritis: Isotype Prevalence and Clinical Oucome - Angeletti A, Bruschi M, Alvise Ramirez G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSLupus nephritis (LN) is the most serious organ manifestation of systemic lupus erythematosus (SLE), occurring in 40%–60% of subjects with SLE with worse outcomes. LN is mediated by antibody deposition in glomeruli, but the mechanisms leading to the immune deposits and (...)
02:00
MO005: RPTEC/TERT1 Cells Cultured in Monolayer are not Suitable for Assessing Apolipoprotein A-I uptake due to the Lack of Cubilin–Amnionless (CUBAM) Complex - Llorens Cebrià C, Durán M, Molina Van den Bosch M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRenal proximal tubule epithelial cells (RPTECs) are responsible for solute and protein reabsorption. It has been described that the human RPTEC/TERT1 cell line expresses several transporters, including the cubilin–amnionless–megalin complex that is responsible for the (...)
02:00
MO020: Rare mutation of the IQGAP1 protein in an Algerian family with corticosteroid-resistant nephrotic syndrome - Azouaou L, Oukrif L, Bensnouci A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThere is podocyte involvement in corticosteroid-resistant nephrotic syndrome. A certain number of proteins play an essential role in the biology of the podocyte; the mutation of these proteins generates the aforementioned pathology. The aim of this work is the (...)
02:00
MO030: Familial clustering of a rare UMOD variant in undiagnosed hereditary nephropathy suggests the presence of a common ancestral founder mutation - Kai Xin Chung N, Valluru M, Butland L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSADTKD–UMOD (Autosomal dominant tubulointerstitial kidney disease–UMOD) is a rare genetic disease due to a heterozygous mutation in the UMOD gene encoding uromodulin. It is classically characterized by minimal proteinuria, slowly progressive CKD, hyperuricemia and (...)
02:00
MO045: Kidney involvement in hereditary transthyretin amyloidosis: a cohort study of 103 patients - Solignac J, Delmont E, Fortanier E, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSHereditary transthyretin amyloidosis (ATTR) is a disabling and life-threatening disease that primarily affects the nervous system and heart. Its kidney involvement has been poorly studied and is not well known to nephrologists.METHODWe conducted a retrospective study (...)
02:00
MO046: Exome sequencing of Israeli Druze individuals on dialysis reveals common as well as population- specific monogenic etiologies in ?30% - Shlomovitz O, Yagel D, Barel O, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSGenetic etiologies are estimated to affect ?10% of adults with advanced CKD. However, significant population disparities in genetic kidney disease exist and population-based screening are lacking especially among minority groups. The Druze population is a (...)
02:00
MO200: Risk of Complications after Percutaneous Native Kidney Biopsy in Patients Receiving Anti-Platelet Agents - Fontana F, Cazzato S, Giaroni F, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAlthough discontinuation of antiplatelet agents at least 5 days before kidney biopsy is recommended by most guidelines and commonly advised by nephrologists, the evidence behind this practice is very low. Indeed, few non-randomized studies previously showed a similar (...)
02:00
MO181: Clinical Characteristics and Short-Term outcomes of Hemodialysis Patients with SARS-COV-2 Infection: The Experience of a Covid Nephrology Unit - Fiorentino M, Pronzo V, Grazioso M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSARS-CoV-2 pandemic is pressuring healthcare systems worldwide. Disease outcomes in certain subgroups of patients, such as nephropathic patients, are still scarce. Patients with chronic kidney disease (CKD) and on haemodialysis (HD) are at risk of a more severe (...)
02:00
MO191: Humoral Immune Response of the Additional Chadox1 NCOV-19 Vaccine Following a Two-Dose Inactivated Whole-Virus SARS-COV-2 Vaccination in Patients on Dialysis - Kitpermkiat R, Bruminhent J, Setthaudom C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPatients with end-stage kidney disease (ESKD) are at risk of coronavirus disease 2019 infection and its associated complications. A previous study demonstrated that patients with ESKD on dialysis generated suboptimal humoral immune response (HIR) and lower (...)
02:00
MO185: Post-Translational Carbamylation of Sortilin is Associated with Cardiovascular Calcification in Chronic Kidney Disease - Jankowski V, Saritas T, Kjobly M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSortilin, an intracellular sorting receptor, has been identified as a cardiovascular (CV) risk factor in the general population. Patients with chronic kidney disease (CKD) are highly susceptible to developing CV complications such as CV calcification. However, (...)
02:00
MO190: Experiences of Being a Living Kidney-Donor-Perceived and Measured Stress Levels before and after Kidney Donation - Andersson H, Lennerling A, Eriksson Svensson M. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSLiving kidney donation is the preferred kidney replacement therapy considering graft function and survival rates. To donate a kidney is a life-changing experience, and there is a diverse spectrum of emotions connected to this process. The aim of this study was to (...)
02:00
MO180: Reactogenicity of MRNA-1273 Vaccine in Patients on Haemodialysis - Alfano G, Fontana F, Morisi N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSmRNA-1273 vaccine (previously known as vaccine Moderna) has shown 94.1% efficacy at preventing COVID-19 illness in the general population. Vaccine-related adverse events (AEs) were usually mild or moderate in intensity and resolved within a few days. Nevertheless, the (...)
02:00
MO189: The Clinical Relevance of Measured GFR in Patients with Solitary Kidney after Radical Nephrectomy: The Estimation is not Enough - Trevisani F, Quattrini G, Franchini M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) represents the major postoperative long-term complication in patients who undergo radical nephrectomy (RN) for the presence of a renal mass. The development of a mild to severe grade of CKD can dramatically change the lifespan of this (...)
02:00
MO196: Moderate-To-Severe CKD-Associated Pruritus (CKD-AP) is Independently Associated with Worse Health-Related Quality of Life (HRQOL) Among Dialysis Patients - Ion Titapiccolo J, Bellocchio F, Goethel-Paal B, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease–associated pruritus (CKD-aP) is common, yet underrecognized condition among end-stage kidney disease patients. We sought to evaluate the prevalence of CKD-aP and its impact on health-related quality of life (HRQOL) among dialysis patients across (...)
02:00
MO176: Study of Urinary Monocyte Chemoattractant Protein-1(MCP-1) Level in Morbidly Obese Patients before and After Bariatric Surgeries and its Relation to Renal Function - Sabry A, Eldeep A. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSTo assess the level of renal inflammatory marker monocyte chemoattractant protein -1(MCP-1), measure the urinary MCP to urinary creatinine concentration ratio in morbidly obese patients before and after bariatric surgeries. To study if there any possible relation (...)
02:00
MO188: Elevated Serum Soluble Urokinase-Type Plasminogen Activator Receptor Level is Linked to Aortic Stiffness in Chronic Haemodialysis Patients - Lin W, Lai Y, Hsu B. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSoluble urokinase-type plasminogen activator receptor (suPAR) is associated with inflammation and contributing in the pathogenesis of atherosclerosis. Aortic stiffness is associated with aging-associated vascular diseases and is also an independent risk factor of (...)
02:00
MO192: Renal Outcomes in High Dose Cisplatin in Locally Advanced Squamous Cell Cancer of the Head and Neck: A Monocentric Experience - Trevisani F, Floris M, Quattrini G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSHead and neck cancer (HNC) represents the sixth most common neoplasm worldwide, accounting for 400 000 deaths globally every year. Among HNC, the squamous cell carcinoma (SCCHN) is the most aggressive histology, being responsible for more than 90% of cases. The (...)
02:00
MO198: Outcomes with Finerenone in Patients with Stage 4 Chronic Kidney Disease and Type 2 Diabetes: A Fidelity Subgroup Analysis - Sarafidis P, Ruilope L, Anker S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPatients with stage 4 chronic kidney disease (CKD) and type 2 diabetes (T2D) have a high residual risk of cardiovascular (CV) and kidney disease progression, and effective treatment options to reduce the risk are limited. The non-steroidal selective mineralocorticoid (...)
02:00
MO199: A Phase 1, Open-Label, Crossover Study Evaluating The Effect of a Single Dose of Sodium Zirconium Cyclosilicate on the Pharmacokinetics of Tacrolimus and Cyclosporin - Någård M, Choudhury N, Lisovskaja V, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSodium zirconium cyclosilicate (SZC) is a novel, oral, highly selective potassium binder approved for the treatment of hyperkalaemia (HK) in adults. As well as binding potassium, SZC binds hydrogen ions in the acidic environment of the stomach, causing a transient (...)
02:00
MO178: Renal Function Impairment in Diabetic Patients after Intravitreal Injection of Anti-Vascular endothelial Growth Factor - Rivero Martínez M, Fernandez M, Berzal R, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIntravitreal administration of vascular endothelial growth factor (VEGF) inhibitors is the treatment of a wide variety of retinal diseases. Kidney damage caused by systemic administration is widely known. However, there is not enough information in the literature on (...)
02:00
MO187: Healthcare Costs based on Risk of Progression in Patients with Chronic Kidney Disease - Prasad B, Jafari M, Sharma A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSNephrologists follow patients with chronic kidney disease (CKD) stage G3 and G4 as a homogeneous group with the assumption that everyone had similar rates of progression with scheduled visits and lab investigations based on the stage of the disease. We now recognize (...)
02:00
MO194: A Rare Case of Secondary Haemolytic Uremic Syndrome after ANTI-SARS-COV-2 Vaccination - Spasiano A, Ambrogio M, Urciuolo F, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSHaemolytic uremic syndrome (HUS) is a rare disease characterized by macroangiopathic haemolytic anaemia, thrombocytopaenia and severe AKI, belonging to the thrombotic microangiopathies (TMAs). It is divided into typical and atypical HUS: the first one occurs most (...)
02:00
MO201: Effects of Aspirin in Primary Prevention of Cardiovascular (CV) Disease in People with Chronic Kidney Disease (CKD): Results of the TIPS3 Trial - Mann J, Joseph P, Gao P, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMS Subjects with CKD carry a high (CV) risk. Whether this risk is blunted by aspirin is controversial. We examined CV outcomes of CKD participants of the TIPS3 trial.METHODThe International Polycap Study3 (TIPS3) randomized people (N = 5713) with and without CKD, but (...)
02:00
MO182: Safety Analysis of Anticoagulant Therapy in Stage 4 CKD in Combination with AF - Igamberdieva R, Abdullaev S. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSA renocardial comorbid condition with a combination of chronic kidney disease (CKD) and atrial fibrillation (AF) increases the risk of thromboembolic complications (TEC) and hemorrhagic events. As kidney function worsens, this risk only increases. Anticoagulant (...)
02:00
MO186: Third COVID-19 Vaccine Dose Maximizes Antibody Titer in Kidney Transplant Recipients - Fonto G, Simone S, Pesce F, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCOVID-19 infection in solid organ transplant recipients (SOT) is associated with increased morbidity and mortality due to comorbidities and immunosuppression state (Chaudhry ZS et al, 2020). Although vaccines represent the greatest hope to control COVID-19 pandemic, (...)
02:00
MO154: Enteric Budesonide in IGAN Nephropathy: A Real World Clinical Practice - López Martínez M, Agraz I, Bermejo S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe gut–kidney axis seems to have a principal role in immunoglobulin A nephropathy (IgAN) development [1], leading to new treatment approaches. Enteric budesonide, a glucocorticosteroid that release the active drug in the distal ileum, has proved proteinuria reduction (...)
02:00
MO155: The Importance of Measured GFR in Clinical Practice: An Old Knowledge for Nephrologists, a New Challenge for Oncologists and Surgeons - Trevisani F, Quattrini G, Franchini M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIn daily clinical practice, an accurate assessment of renal function is of paramount importance in several categories of patients where the adequate medical or surgical treatment depends on the values of glomerular filtration rate (GFR). In particular, both (...)
02:00
MO171: Chronic Inflammation Might Protect Haemodialysis Patients from Severe COVID-19 - Prietl B, Odler B, Kirsch A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPatients on haemodialysis (HD) are expected to have excess mortality in coronavirus disease 2019 (COVID-19). This was challenged by a recent study reporting HD patients to have comparable mortality and decreased ICU admissions when hospitalized with COVID-19. It was (...)
02:00
MO163: Mycophenolate Mofetil Superior to Azathioprine and as Effective as Calcineurin Inhibitors in Lupus Nephritis Maintenance Therapy: Data from a Single Centre Prospective Study - Mirela Stroie A, Penescu M, Paul B. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSystemic lupus erythematosus is the prototype of a multiorgan, multisystemic autoimmune disease. It has relatively frequent renal involvement (prevalence of 15–60%). A total of 19–25 patients develop end-stage renal disease after 10 years of disease onset. We studied (...)
02:00
MO170: Systematic Review of Patients with Chronic Kidney Disease Undergoing Fertility Treatment - Bhaduri M, Gama R, Sarris I, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe prevalence of chronic kidney disease (CKD) in women of reproductive age continues to rise and reduced fertility is recognized even with mild disease. A greater proportion of women with CKD are seeking assisted reproductive technology (ART) treatment; however, our (...)
02:00
MO152: SARS-COV-2 Infection and Kidney Impairment - Tanasescu M, Botocan A, George Bogdan Tanase E, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe objectives of the present study are to compare the renal impairment between patients with SARS-COV-2 in two different time periods with dominant beta and delta SARS-COV-2 variants, with or without prior chronic kidney disease (CKD).METHODThe study was performed on (...)
02:00
MO167: SAFETY OF SGLT2 INHIBITORS (SGLT2I) IN PEOPLE OVER 75 YEARS - Vidas M, Domenech E, Testillano L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe use of iSGLT2 in people over 75 years was initially associated with a higher rate of adverse effects (AEs). Subsequent clinical trials have consistently demonstrated no increase of serious adverse effects in this group of patients, but the incidence of minor (...)
02:00
MO151: A Randomized Controlled Trial of Sodium Zirconium Cyclosilicate Versus Standard of Care for Hyperkalaemia in Chronic Kidney Disease: Phase 4 Continuity Study Design and Rationale - Burton J, Allum A, Amin A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIndividuals hospitalized with hyperkalaemia (HK) and chronic kidney disease (CKD) are at very high risk of HK recurrence, which often requires hospital re-admission [1]. Recurrent HK events have a significant impact on healthcare resource utilization (HCRU) and costs (...)
02:00
MO166: The Longitudinal Evolution of Covid-19 Outcomes Among Hemodialysis Patients: A Nationwide Multicentre Controlled Study - Ozturk S, Turgutalp K, Arici M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSHaemodialysis (HD) patients are at increased risk for adverse short-term consequences of COVID-19. In this study, we investigated the characteristics of chronic HD patients in the post-COVID-19 period and compared them with the control group.METHODWe conducted a (...)
02:00
MO175: Association between Thrombotic Microangiopathy, ADAMTS13 Activity and Development of AKI, ARDS, AND Poor Outcomes in COVID-19 Patients (Pilot Study) - Vorobyev E, Vorobyeva S, Galkina O, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCases of microangiopathy associated with COVID-19 are not fully understood. We aimed to clarify in these patients the presence of thrombotic microangiopathy (TMA) and decreased ADAMTS13 activity, the possible influence of these factors on kidney and lung damage, and (...)
02:00
MO158: The Association of Left Ventricular Diastolic Dysfunction and Heart Failure in Patients with Chronic Kidney Disease - Babovic B, Belada Babovic N, Radovic M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) has been linked with an increased risk of cardiovascular events, especially in dialysis population. According to literature data, in the patients with CKD heart function disturbances are twice as common as in the general population [1]. (...)
02:00
MO165: The Controversial Role of Proteinuria and Urinary Output After Radical Nephrectomy in the Development Of Acute Kidney Injury: Double Agents - Trevisani F, Cinque A, Quattrini G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is increasingly common and associated with adverse short- and long-term outcomes in oncological patients who require radical nephrectomy (RN) for the presence of renal cancer. As defined by the KDIGO Criteria classification system, the (...)
02:00
MO153: Study of the Relationship between Atrial Fibrillation and The Functional State of the Kidneys in Patients with CHF - Karimdjanova G. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic heart failure (CHF) is one of the most significant medical, economic and social problems of the 21st century. According to epidemiological studies, the prevalence of CHF in the USA and Western Europe ranges from 1.9% to 2.5% (Rosamond W. et al. 2007; Neumann (...)
02:00
MO164: Is there a Place for the Resistivity and Pulsatility Index in Diabetic Nephropathy? - Liana Gliga M, Chirila C, Gliga M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSResistivity index (RI) and pulsatility index (PI) are important Doppler ultrasound (US) parameters for the evaluation of intrarenal haemodynamics. One of the pathogenetic mechanism in diabetic nephropathy (DKD) is the arteriolar hyalinosis and the interlobar arteries (...)
02:00
MO174: Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits: Rare Disease with Poor Prognosis? - Chub O, Dyadyk O, Ivanov D. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSProliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMIDs) is a recently described disease among the spectrum of monoclonal gammopathy of renal significance (MGRS). The disease is renal limited and manifests with chronic glomerular disease, (...)
02:00
MO157: Evaluating the Effect of SGLT2 Inhibitors on Proteinuria and Glomerular Filtration Rate in Non-Diabetic Patients with Proteinuria - Afrooghe A, Nematollahi N, Sadat Hakemi M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSProteinuria is strongly associated with the risk of CKD progression in non-diabetic and diabetic patients. SGLT2 inhibitors, as a promising new class, may provide protective effects for the kidney. Even though various studies have been conducted in this area, (...)
02:00
MO150: Serum Angiopoietin-Like Protein 3 Level is Negatively Associated with Vascular Reactivity Index by Digital Thermal Monitoring in Chronic Haemodialysis Patients - Wu T, Huang H, Lin W, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAngiopoietin-like protein 3 (ANGPTL3) plays important roles in lipid and lipoprotein trafficking and metabolism and has demonstrated a positive correlation with cardiovascular risk assessment parameters of carotid and femoral artery intima-media thickness. We (...)
02:00
MO162: Renal Function During Long-Term Use of Oral Anticoagulants in Patients with Atrial Fibrillation - Abdullaev S, Igamberdieva R. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSLong-term oral anticoagulant should be recommended in patients with atrial fibrillation (AF) and CHA2DS2VASc score ? 1 for stroke prevention. Warfarin and different direct oral anticoagulants are metabolized differently by the kidney. The impact on renal function (...)
02:00
MO168: Urinary Podocin Cell Count in Relation to Glomerular Damage Markers in Patients with Primary Nephrotic Syndrome - van den Berge T, Jansen J, van de Logt A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSProgressive renal failure in patients with glomerular disease is driven by podocyte depletion. Several methods have been proposed to monitor urinary podocyte loss. Here, we investigated the process of podocyte depletion in patients with primary nephrotic syndrome (...)
02:00
MO172: Correlation of Serum Adipocyte Fatty Acid Binding Protein Level and Peripheral Arterial Disease in Chronic Kidney Patients - Boey H, Liao T, Wang C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAdipocyte fatty acid-binding protein (A-FABP) is expressed in adipocytes, dendritic cells and macrophages and it was thought to be involved in insulin resistance, chronic inflammation and atherosclerotic processes. Peripheral arterial disease (PAD) is associated with (...)
02:00
MO173: Clinical Profile of Plasma Cell Dyscrasias and Their Renal Outcomes - Mulpuri N, Attur Prabhu R, Prasad Nagaraju S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe involvement of kidney in plasma cell dyscrasias is widespread, often referred to as myeloma kidney. At the time of presentation, nearly 50% of patients have renal involvement which is associated with higher mortality [1, 2]. Multiple myeloma is more common in (...)
02:00
MO156: The Choice of Empiric Antimicrobial Agent and its Association with Outcomes in Kidney Transplant Recipients with Urinary Sepsis - Królicki T, Bardowska K, Kudla T, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSEfficient antibiotic therapy remains the cornerstone of successful sepsis treatment. Urinary sepsis, which remains the most common sepsis type in kidney transplant recipients (KTRs), is characterized by high prevalence of multidrug-resistant (MDR) bacterial strains, (...)
02:00
MO161: Comparison of Therapeutic Plasma Exchange with Centrifugation and Filter Technique with a Focus on Efficacy, Safety, Platelet Loss and Patients' Comfort - Frimmel S, Mitzner S, Hinz M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSTherapeutic plasma exchange (TPE) is an established therapy in the treatment of various immunologic kidney and neurological diseases. Humoral factors as antibodies, complement factors, cytokines and immune complexes, which all are assumed to play a role in (...)
02:00
MO159: Serum Trimethylamine N-Oxide Level is Positively Associated with Aortic Stiffness Measuring by Carotid-Femoral Pulse Wave Velocity in Maintenance Haemodialysis Patients - Lai Y, Lin W, Hsu B. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSTrimethylamine-N-oxide (TMAO) acts as an evident predictor for the prevalence of cardiovascular disease and increased incidence of major adverse cardiovascular events. Aortic stiffness predicts cardiovascular disease and is associated with ageing-associated vascular (...)
02:00
MO160: Prolonged Closure Times in the Absence of Anti-Platelet Therapy and the Incidence of Haemorrhagic Complications After Native Kidney Biopsy - Avgustin Rotar N, Rotar Z, Ales Rigler A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe closure times [CTs; i.e. collagen/epinephrine (COL Epi) and collagen/adenosine 5-diphosphate (COL ADP)] are frequently used to evaluate primary haemostasis before kidney biopsy, although their usefulness to predict hemorrhagic events remains elusive [1]. CTs can (...)
02:00
MO169: Three Doses of SARS?COV?2 BNT162B2 MRNA Vaccine Results in an Enhanced Immunologic B- And T-Cell Response in Haemodialysis Patients - Melin J, Eriksson Svensson M, Albinsson B, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe immune system is affected by uremia. Haemodialysis (HD) patients have an increased risk of acquiring infections due to many healthcare contacts and have a suboptimal response to vaccination and a high mortality from COVID-19 infection. Accumulating data indicate (...)
02:00
FC079: The Race-Free EGFR Equation, The Kidney Failure Risk Equation and Referrals to Specialist Renal Clinics - Sullivan M, Mark P, Mair F, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe new race-free estimated glomerular filtration rate (eGFR) was developed in 2021. Recently in the UK in keeping with similar initiatives elsewhere, the kidney failure risk equation (KFRE) to predict the risk of kidney failure has been incorporated into clinical (...)
02:00
FC077: Cystatin C Testing Improves Risk Stratification Associated with Chronic Kidney Disease Without Adopting Age-Adapted Diagnostic Thresholds: A UK Biobank Study - Lees J, Rutherford E, Stevens K, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAge-adapted thresholds of estimated glomerular filtration rate (eGFR) have been proposed for the diagnosis of chronic kidney disease (CKD) [1] to acknowledge decline in kidney function with increasing age [2]. Proponents of age-adapted thresholds suggest that subjects (...)
02:00
FC078: Impact of Removing Race from the CKD-EPI Equation: Analysis of 1.6 Million Swedish Adults - Fu E, Coresh J, Grams M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) recently developed a novel creatinine-based eGFR equation without a race coefficient. While American nephrology societies recommend using this novel equation, its implications are unknown.METHODWe (...)
02:00
FC080: A Systems Nephrology Framework for the Molecular Classification of Chronic Kidney Disease - Bohnenpoll T, Olson E, Dergai M, et al. Nephrol Dial Transplant

AbstractBACKGROUNDConventional stratification by clinical and histopathological phenotypes only approximates the heterogeneity of chronic kidney disease (CKD) and is insufficient to drive discovery of disease-modifying therapies or predict clinical outcomes. Recent advances in molecular (...)
02:00
MO146: Effects of High-Intensity Exercise on Renal and Endothelial Function of Crossfit Athletes - Cesar Chaves Nunes Filho J, Castelo Branco Holanda Gadelha Pereira D, Salviano de Matos R, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSHigh-intensity exercise modalities such as Crossfit have increased the number of practitioners due to the benefits such as weight loss. However, high-intensity exercise can induce renal and endothelial damage. The objective was to verify the main acute effects of (...)
02:00
MO124: Intradialytic Symptomatology is Largely Patient-Specific in both Haemodialysis and Haemodiafiltration: A Randomized Cross-Over Trial between Four Intermittent Dialysis Modalities - Wijngaarden G, Rootjes P, de Roij van Zuijdewijn C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSStandard haemodialysis is associated with a considerable burden of intradialytic symptoms. Although haemodialysis with cool dialysate is associated with less intradialytic discomfort in general, the incidence of cold sensations increases significantly. Whether (...)
02:00
MO137: Sarcoidosis in a Living Kidney Donor Candidate: Case Report and Review of the Literature - Mori G, Tei L, Alfano G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSarcoidosis (SCD) is a granulomatous disease that mostly affects young adults, presenting with hilar adenopathy, lung reticular opacities and skin/joint/eye lesions. Incidence varies in Europe between 0.3% and 1.5%, higher in southern countries. Up to one-third of (...)
02:00
MO138: The Level of Microrna Expression in Urine of Cynomolgus Monkeys, Who Received Diet Rich in Common Salt - Kayukov I, Zaraiski M, Beresneva O, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSHigh consumption of NaCl is traditionally considered the cardiovascular risk factor and the blood pressure (BP) growth factor. The considerable sodium content in the diet is associated with myocardium remodelling. Recently, attention has been also paid to studying the (...)
02:00
MO123: The Correlation of Platinum-Based Chemotherapy with Decreased Blood Ionized Magnesium in Cancer Patients - Jiang D, LI Y, Huang F, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPlatinum-based agents are prescribed as backbone chemotherapy for lung, colorectal, esophagogastric, breast, testicular and ovarian cancers, among others. Renal excretion of platinum-based agents is mediated by the cellular transporters localized in renal tubules. (...)
02:00
MO130: Effect of Long-Term Low Protein Diet Use at Myocardium Remodelling in Rats With Experimental Decrease of Working Nephrons Weight - Beresneva O, Parastaeva M, Ivanova G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCardiovascular disturbances are the most frequent cause of death in patients with chronic kidney disease (CKD). Various options of low protein diets (LPD) are widely used in CKD treatment. However, their role in cardioprotection at CKD is understudied. The aim was to (...)
02:00
MO131: Prevalence of Pruritus in Spanish Patients with Chronic Kidney Disease and Affectation of Quality of Life - Areste-Fosalba N, Emilio S, Henriquez F, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe prevalence of chronic kidney disease–associated pruritus (CKD-aP) found in different studies ranges from 40% to 90% in patients undergoing haemodialysis, and from 19% to 29% in non-dialysed patients. However, despite pruritus negatively affect the quality of life (...)
02:00
MO149: Effect of Plasma Exchange on COVID-19 Associated Excess of Von Willebrand Factor and Inflammation in Critically Ill Patients - Seibert F, Blazquez-Navarro A, Hölzer B, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSUbiquitous microthromboses in the pulmonary vasculature play a crucial role in the pathogenesis of COVID-19 associated acute respiratory distress syndrome (ARDS). Excess of von Willebrand factor (vWf) with intravascular multimer formation was identified as a key (...)
02:00
MO110: Ultrasound Evaluation of Post-COVID Kidney Disease - Rostyslav B. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCOVID can affect many organs including kidneys involving various possible pathophysiological mechanisms [1]. Post-COVID conditions require focused approach for diagnosis, personalized treatments and rehabilitation. Ultrasonography (US) can provide accurate information (...)
02:00
MO098: Emphysematous Pyelonephritis in Bangladesh over a Decade, 2012–2021 - Abdur Rahim M, Samad T, Mohosin Ul Haque W. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSEmphysematous pyelonephritis (EPN) is an acute and severe form of necrotizing infection of the renal parenchyma, collecting system and/or perinephric tissues, and it is characterized by accumulation of gas within these anatomic locations. Common presenting features (...)
02:00
MO117: Predictive Factors for Renal Impairment Secondary to Familial Mediterranean Fever in an Algerian Population - Ghalia K, Benziane A, Benabadji M. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe aim of this study was to assess predictors of renal involvement and other factors secondary to FMF in renal and overall survival.METHODWe prospectively studied 57 Algerian patients admitted to our nephrology department from January 2012 to January 2021. The (...)
02:00
MO132: Gait Speed in Predialysis Chronic Kidney Disease Patients: A Cross-Sectional Study from the Role of AST120 in Sarcopenia Prevention in Pre-Dialysis Chronic Kidney Disease Patients - Chul Kim J, Han M, Heon Song S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSGait speed (GS) is an important measure of functional ability. The aim of this study was to investigate the factors associated with GS in patients with chronic kidney disease with respect to sarcopenic component, plasma uremic or inflammatory markers and quality of (...)
02:00
MO147: Fat Check: Lipid Abnormalities in Nephrotic Primary Glomerulopathies - Cristina Martins A, Francisco D, Pimenta G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSLipid abnormalities are a defining feature of nephrotic syndrome. In nephrotic patients, changes such as increased total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) and decreased high-density lipoprotein cholesterol (HDL-C) as (...)
02:00
MO148: CT-Guided Native Kidney Biopsy by Interventional Nephrologists - Mohamed Amine R, Michel Marc J, Deprele C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSHistopathology of renal parenchyma is the key diagnostic in the treatment of kidney diseases by nephrologists. Most nephrologists perform renal biopsy using percutaneous ultrasound-guided technic. Generally, this act is very simple for the majority of patients, but (...)
02:00
MO106: Circulating Neutrophil Count is Associated with Severity of Chronic Kidney Disease - Carrara F, Ruggenenti P, Parvanova A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSNeutrophils (Ns) play a key role in inflammation and tissue injury, in particular in acute renal failure, by releasing a complex of cytotoxic products such as reactive oxygen intermediates, enzymes and microbicidal polypeptides. These effects are prevented or (...)
02:00
MO116: Vitamin C Nephrotoxicity in a COVID-19 Patient: A Case Report - Lemee N, Chamley P, Francois A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSDuring the time of the COVID-19 pandemic, multiple treatment options have been investigated, even though their efficacy and secondary effects remain insufficiently known.We report the case of a vitamin C induced oxalate nephropathy in a COVID-19 patient with (...)
02:00
MO126: A ‘Point Prevalence’ Pain Study over 2 Days in Three Dialysis Units in the West of IRELAND - Gorey D, Lappin D, Murphy D, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPoint prevalence studies are observational studies, without intervention, and involve collecting data, in patients in multiple care units, at a specific time. It provides no information on outcomes but provides information on how common a problem is, and current (...)
02:00
MO143: Dynamics of Renal Function during Anticoagulant Therapy in Stage 4 CKD and AF - Igamberdieva R, Abdullaev S. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAtrial fibrillation (AF) significantly increases the risk of developing end-stage chronic kidney disease (CKD). It should also be borne in mind that as kidney function deteriorates the risk of AF progression and its complications increases. Various studies have shown (...)
02:00
MO144: Behind the Scenes: A Year in an Onco-Nephrology Outpatient Clinic in Italy - Pirovano M, Cosmai L, Vanessa Re Sartò G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe progressive increasing awareness of the need for a multidisciplinary management of cancer patients, the rapid development of new anti-cancer therapies, the prolongation of oncological patients’ survival and the increased incidence of chronic kidney disease (CKD) (...)
02:00
MO104: Predictors for Early Mortality in Myeloma-Related Kidney Disease - Cadri V, Saraci A, Pasko N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRenal failure severe enough to require dialysis is an independent predictor of poor survival outcomes in multiple myeloma (MM). Significant early mortality (EM) was also determined in patients with MM infected by COVID-19. To evaluate the EM rate and investigate the (...)
02:00
MO115: Cardiorenal Units as Management Strategy to Improve Outcomes in Cardiorenal Syndrome - Marques M, Cobo M, García Magallón B, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCardiorenal syndrome (CRS), defined as the spectrum of disorders that acutely or chronically affect both heart and kidney function, is often a challenging condition with paucity of evidence-based therapy. The increasing burden of this entity has prompted the creation (...)
02:00
MO122: Bleeding Complications after Allograft Kidney Biopsy and Role of Antiplatelet Therapy - Cazzato S, Fontana F, Giaroni F, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPercutaneous biopsy is an important tool for monitoring renal allograft and early diagnosis when dysfunction occurs. Bleeding is the most dangerous adverse event, even if it is rare (risk of 0.5%). Cardiovascular (CV) disease affects 2/3 of elderly with CKD and (...)
02:00
MO141: Antibody Response against SARS-COV-2 in Dialysis Patients During COVID-19 - Christian Østergaard H, Mose F, Lauridsen T, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPatients in haemodialysis are a vulnerable group, thought to have a poor antibody response to vaccination. In Denmark dialysis, patients were one of the first patient groups to be vaccinated against COVID-19. By investigating the antibody response of dialysis (...)
02:00
MO142: Urinary Hemopexin As a Marker of Lupus Activity Among Egyptian SLE Patients with Proliferative Lupus Nephritis - Sabry A, Mahmoud R. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSTo assess the role of urinary hemopexin in prediction of active lupus nephritis (LN) and correlate its level with disease activity and ability to predict response to induction therapy in Egyptian SLE patients with nephritis.METHODA cohort case-control hybrid study (...)
02:00
MO105: Study of 45 Cases of Membranous Nephropathy from a Kidney Biopsy Record at the Level of the Nephrology Department in Marrakech - Mikdam N. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMembranous nephropathy is the most common cause of nephrotic syndrome in adults. However, the epidemiological data of this disease are not yet sufficiently known in our country. The aim of our study was to determine the clinical, biological and histological profile of (...)
02:00
MO114: Incidence and Spectrum of Biopsy-Proven Dysproteinemic Kidney Diseases: A Single-Centre Experience - Zhuan Tan H, Nagarajan C, Si Yun Tan M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSWe aimed to evaluate the incidence and clinical features of patients with biopsy-proven dysproteinemic kidney diseases (group 1), as well as spectrum of biopsy-proven kidney diseases of patients with monoclonal gammopathy (MG) or abnormal free light chain (FLC) ratio (...)
02:00
MO125: Association of Bladder Post-Void Residual Volume and Urinary Tract Infection in Adult Females - Maramba N, Patricia Lim F, Leano J. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSUrinary retention is the inability to voluntarily pass a sufficient amount of urine [1]. This predominantly affects males often due to benign prostatic hyperplasia [1]. In patients with symptomatic urinary retention, initial management such as urethral catheter (...)
02:00
MO133: Multidisciplinary Regenerative Treatment for Rescuing a Severe Calciphylaxis Patient with Human Amnion-Derived Mesenchymal Stem Cells - Wang N, Qin L, Liu K, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCalciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis, with high mortality and no proven therapy. Here, we reported multidisciplinary regenerative treatment for rescuing a severe uremic calciphylaxis patient with (...)
02:00
MO134: Follow-Up of Patients with Vasculitis: A 10-year retrospective study - Kozikopoulou D, Oikonomaki T, Paikopoulou A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSVasculitis constitutes a systemic disease with renal involvement at almost 100% in microscopic polyangiitis, 70–80% in granulomatosis with polyangitiis, 25% in eosinophilic granulomatosis with polyangitiis and 40–50% appears as renal limited vasculitis. In order to (...)
02:00
MO099: Elastography in the Assessment of Chronic Kidney Disease: A Meta-Analysis - Maralescu F, Chiodan M, Sircuta A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSWe require an imagistic quantitative technique for the diagnosis and assessment of chronic kidney disease (CKD). Renal elastography has been widely used in the last years in different studies; however, the results across them are not consistent and, as a result, we (...)
02:00
MO113: Estimation of Hypocalcaemia, Hypoalbuminemia and Hypomagnesaemia Prevalence in Patients with COVID-19 and its Relationship with Clinical Manifestations and Disease Progression - Hashemi S, Salmanzadeh S, Mobarak S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSElectrolyte abnormalities are common among patients with coronavirus disease 2019 (COVID-19). This study aims to investigate the electrolyte changes in severe and non-severe COVID-19 patients. Hypocalcaemia, hypomagnesaemia and hypoalbuminemia and their relationship (...)
02:00
MO120: Kidney Biopsy—Safety at Neprology Gold Standard - Marques F, Silva O, Outerelo C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSPercutaneous renal biopsy is a fundamental technique for the diagnosis of numerous renal pathologies. However, it is an invasive technique that requires operator experience and is associated with adverse outcomes. Bleeding complications such as haematuria or perirenal (...)
02:00
MO145: Chest CT Total Severity Score on Admission to Predict In-Hospital Mortality in Patients with Acute and Chronic Renal Impairment with COVID-19 Infection - Tharwat S, Saleh G, Saleh M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCOVID-19 is an infection that has spread widely and quickly over the world, resulting in a pandemic with substantial consequences for the sociopolitical environment and healthcare delivery systems. The aim of this study was to explore the clinical, laboratory (...)
02:00
MO102: Lean Tissue, as Assessed by Bioimpedance Spectroscopy, Is Dependent on Renal Function in Patients with HFREF - Popa R, Sascau R, Statescu C, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSDespite impressive improvements in treatment strategies, heart failure (HF) morbidity and mortality remain substantially high worldwide. Muscle wasting is common and is associated with increased morbidity and mortality in patients with HF. The aim of the study was to (...)
02:00
MO112: Clinical Features of Allopurinol-Induced DRESS/DIHS in 46 Patients - Liu Q, Zhao S. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAllopurinol is the first-line prescribed agent for hyperuricemia and gout. Allopurinol-induced drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but serious and potentially life-threatening drug hypersensitivity syndrome. This study aimed to (...)
02:00
MO121: The Relationship between Perceived Stress with Anxiety, Depression, Sleep Quality, Insomnia and Drug Adherence in Patients with Systemic Lupus Erythematosus during the COVID-19 Pandemic - Gokmen K, Barutcu Atas D, Tugcu M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSleep disorders, depression and anxiety are commonly reported in patients with systemic lupus erythematosus (SLE). Public health emergencies such as pandemics can also increase these psychosocial distresses. Early diagnosis and treatment of these disorders will (...)
02:00
MO135: Efficacy and Safety of Bortezomib Combined with Autologous Stem Cell Transplantation in the Treatment of MGRS - Zhao L, Ren G, Guo J, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSTo evaluate the efficacy and safety of bortezomib combined with autologous stem cell transplantation (ASCT) in the treatment of monoclonal gammopathy of renal significance (MGRS).METHODThe clinicopathologic data of 16 patients with non-AL MGRS who received bortezomib (...)
02:00
MO136: Histological Findings in Checkpoint Inhibitor-Induced Nephropathy - Gerakis A, Kaitantzoglou C, Giatras I, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSImmune checkpoint inhibitors (CPIs)—a landmark in cancer therapy—has been occasionally associated with immune-related nephropathy [1]. Acute interstitial nephritis is considered to be the most common underlying histological entity, according to recent literature [2]. (...)
02:00
MO103: ANCA Vasculitis with Renal Impairment in the Elderly - Chemli I, Hammouda M, Ben Salem M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSANCA vasculitis is a serious pathology and life threatening. Kidney damage is common. Few studies have focused on ANCA vasculitis in the elderly. The geriatric population is particular by its polypathology and its polypharmacy. Our objective was to detail the (...)
02:00
MO111: Hyperuricaemia and Risk of Simple Renal Cysts - Valentinova Monova D, Kamenov A, Milenova V, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe relationship between hyperuricaemia and renal cysts is still insufficient. Simple renal cysts (SRCs) are the most common non-hereditary type of benign renal cysts in adults. The prevalence of SRC varies by population, geographic region and the imaging modality (...)
02:00
MO119: Lupus Nephritis in Males: About 34 Cases - Afifi R, Elkhayat S, Medkouri G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSLupus nephritis (LN) is one of the most serious manifestations of systemic lupus erythematosus (SLE), affecting mainly young women, but can also affect men. It refers to the development of intrarenal tissue inflammation responsible for various damage at this level: (...)
02:00
MO139: Advance Care Planning in Hemodialysis: A Challenge for the Italian Nephrology - Simone G, Toccafondi A, Ferro G, et al. Nephrol Dial Transplant

AbstractBACKGROUNDAdvance care planning (ACP) enables competent patients to define goals and preferences for future treatments and care, to discuss these goals and preferences with relatives, and if appropriate to record these preferences [1]. After many years of political and social debates, (...)
02:00
MO140: Lower Serum 25-Hydroxyvitamin D Levels are Associated with Peripheral Arterial Stiffness in Patients with Non?Dialysis Chronic Kidney Disease Stage 3–5 - Liao T, Boey H, Lai Y, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSVitamin D deficiency is associated with a higher mortality and incidence of cardiovascular disease. High brachial-ankle pulse wave velocity (baPWV) is independently associated with an increased risk of cardiovascular events, cardiovascular mortality and all-cause (...)
02:00
MO101: Atypical Haemolytic Uremic Syndrome Associated with COVID-19: Case Report - Gjyzari (Velaj) A, Muco E, Como N. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSRenal manifestations are common in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report here the case of a patient with confirmed SARS-CoV-2 infection with the clinical picture of atypical haemolytic uremic syndrome (...)
02:00
MO107: Association of Renal Function with Cardio Metabolic Risk Factors in Elderly Population - Kibria G, Iqbal M, Shahnoor Alam K, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSElderly population is a vulnerable group, and cardiometabolic risk factors are highly prevalent among them. This situation complicates when the renal function becomes impaired. The aim of this study was to evaluate the association of renal function with (...)
02:00
MO109: Staphylococcal Scalded Skin Syndrome in a Young Adult Patient Undergoing Haemodialysis - Todorova G, Akisheva A, Stoimenova M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSStaphylococcal scalded skin syndrome (SSSS) is an infection caused by certain strains of Staphylococcus aureus (usually phage group II), which produce an exfoliative toxin (ET) that causes cleavage of the epidermis at the level of the lower granular layer resulting in (...)
02:00
MO100: Alectinib-Induced Reversible Acute Kidney Injury - Conceição S, Moreira Fonseca N, Navarro D, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAlectinib is a second generation anaplastic lymphoma kinase (ALK) tyrosine inhibitor approved for ALK-positive lung adenocarcinoma. This drug may be associated with acute kidney injury, mainly causing acute tubular necrosis. Usually inducing a reversible chronic (...)
02:00
MO108: Paraneoplastic Nephrotic Syndrome in a Man with Breast Cancer - Michelassi S, Somma C, Mehmetaj A, et al. Nephrol Dial Transplant

AbstractBACKGROUNDNephrotic syndrome is associated with many solid tumours and haematologic malignancies. Membranous nephropathy (MN) is the most commonly reported paraneoplastic glomerulonephritis; about 10% (rate 5–20%) of adults with MN have been reported to have a malignancy [1]. Less (...)
02:00
MO118: A Study on Renal Involvement in COVID-19 Patients with or without Preexisting Kidney Disease and Outcome: Acha Single-Centre Retrospective Study - Sharma M, Brijesh S, Pegu G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) patients and renal allograft recipients (RARs) are at increased risk for severe coronavirus disease 2019 (COVID-19). Acute kidney injury (AKI) can develop in a patient with COVID-19 infection. Data regarding the outcome of COVID-19 (...)
02:00
MO128: Predisposing Metabolic Factors to Urinary System Stone Formation in Patients with Autosomal Dominant Polycystic Kidney Disease - Chasan O, Serra Ucar A, Gursu M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe risk of urinary tract stone formation in patients with autosomal dominant polycystic kidney disease (ADPKD) is 20%, twice as high as in the normal population. The most important reason for this increased tendency to stone disease is thought to be anatomic changes (...)
02:00
MO129: Influence of Menstrual Situation on the Risk of Incident Microalbuminuria in School Workers: Miyagi Karoshi Prevention Study - Munakata M, Hattori T, Konno S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSIt has been recognized that menstrual situation impairs diagnostic accuracy of proteinuria. However, it is not fully understood how menstrual situation affects the degree of urinary albumin excretion, a well-known marker of endothelial damage. Moreover, there may be (...)
02:00
MO254: Baseline Characteristics of Patients Enrolled in the Ongoing Phase 3 Randomized, Double-Blind, Active-Control Trial of Sparsentan for the Treatment of Focal Segmental Glomerulosclerosis (DUPLEX) - Trachtman H, Radhakrishnan J, Komers R, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSUncontrolled focal segmental glomerulosclerosis (FSGS) often follows a progressive course to end-stage kidney disease and has a profound negative impact on patient quality of life and long-term survival. Treatments that reduce proteinuria and risk of kidney disease (...)
02:00
MO255: Sparsentan Protects the Glomerular Basement Membrane and Glycocalyx, and Attenuates Proteinuria in a Rat Model of Focal Segmental Glomerulosclerosis (FSGS) - Bedard P, Jenkinson C, Komers R. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSparsentan is a novel, dual acting, highly selective antagonist of the endothelin (ET-1) type A receptor (ETAR) and the angiotensin II (Ang II) subtype 1 receptor (AT1R). This first in class dual endothelin angiotensin receptor antagonist (DEARA) is being investigated (...)
02:00
MO247: Exogen ATP has a Suppressive Effect on CD4+-T-Cells In Aav-Patients And Healthy Controls - Haase A, Yang D, Dolff S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAnti-neutrophil-cytoplasmatic-antibody-associated vasculitis (AAV) is a life-threatening autoimmune disease. It is a necrotizing vasculitis of small- and medium-sized vessels. T-cells play a pivotal role in pathogenesis and mediating damage in the vessels. Exogen ATP (...)
02:00
MO272: Effect of the Hollow Fiber Diameter and Membrane Surface Area of the Polymethyl Methacrylate Membrane Filter Used in Continuous Renal Replacement Therapy on the Lifetime of the Filter - Kurihara Y, Kobayashi Y, Ushiroda Y, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSWhen polymethyl methacrylate (PMMA) membranes are used in renal replacement therapy, inflammatory cytokines and other substances are removed by adsorption. However, these filters are also prone to clogging and the filter lifetimes are likely to be short. In the (...)
02:00
MO273: Water Restriction and Age Increase the Risk of Triple Whammy-Induced Acute Kidney Injury - María Baranda Alonso E, Fuentes-Calvo I, Sancho Martinez S, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSHypertension has a high prevalence in adult population and represents an important cause of premature death worldwide. Its treatment often consists of the combination of several antihypertensive drugs, including angiotensin-converting-enzyme inhibitors (ACEi) or (...)
02:00
MO274: Vancomycin Adsorption During In Vitro Model of Hemoperfusion with Mini-Module of HA380 Cartridge - Lorenzin A, de Cal M, Sorbo D, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSSeptic shock is one of the most frequent causes in Intensive Care Unit (ICU) admission and is related to a very high risk of mortality. About one-third of patients with sepsis develops AKI which contributes to a worsening prognosis. AKI due to sepsis is the result of (...)
02:00
MO275: A Biomarker of Acute Kidney Injury from Proven Renal Origin - Paniagua Sancho M, Quiros Y, Casanova A, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a threatening, multi-aetiological syndrome encompassing a variety of forms and damage patterns. AKI lacks sufficiently specific diagnostic tools to evaluate the distinct combination of pathophysiological events underlying each case, which (...)
02:00
MO177: The Impact of a Low-Normal Protein High Calorie Diet on the Nephrological Scenario and Perceived Quality of Life of Oncourological Patients with Chronic Kidney Disease - Bettiga A, Quattrini G, Fiorio F, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSNutritional therapy (NT) based on controlled protein intake represents a cornerstone in the management of chronic kidney disease (CKD). However, the international guidelines do not precisely define an adequate protein intake for onconephrological patients. The aim of (...)
02:00
MO179: Cardiovascular Disease and Mortality in ANCA-Vasculitis. Importance of Overadded Hypertension and Kidney Function: A South of Spain's Experience - Rodríguez Torres A, Gordillo García L, Espinosa M, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCardiovascular disease (CVD) is one of the principal causes of death in antineutrophil cytoplasmic antibody-(ANCA)-associated vasculitis (AAV), partly due to the vascular inflammation itself, the associated organic damage and the treatment [1]. AAV has been associated (...)
02:00
MO197: Change in the Level Of NFKBP65 Gene Expression in the Myocardium and Kidneys of Wistar Rats and Spontaneously Hypertensive Rats (SHR) That Received Diet Rich in NACL - Beresneva O, Parastaeva M, Ivanova G, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSThe notions that a diet rich in common salt is an independent myocardium remodelling determinant, not associated with blood pressure (BP) increase, attract interest at present time. Possibly, this mechanism is implemented due to activation of proliferative, (...)
02:00
MO183: Prevalence, Spectrum and Renal Prognosis in Monoclonal IGM-Related Kidney Disease: One Centre Experience - Khrabrova M, Dobronravov V, Panina I, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSMonoclonal IgM (mIgM) secreted by B-cell lineage clone is able to damage renal tissue by the variety of mechanisms that leads to kidney dysfunction and progression of chronic kidney disease. In this study, we analyse the prevalence of mIgM-related kidney disease, (...)
02:00
MO195: Kidney Function and the Risk of Heart Failure Among Older Adults: A Prospective Population-Based Cohort Study - Douros A, Schneider A, Ebert N, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSDecreased kidney function is an established risk factor of cardiovascular morbidity including heart failure (HF) as well as cardiovascular and all-cause mortality among adults. However, the role of decreased kidney function with regard to these outcomes among old and (...)
02:00
MO184: Development and Validation of a Multivariable Prediction Model for Nonseroconversion after SARS-COV-2 Vaccination in Kidney Transplant Recipients - Frölke S, Bouwmans P, Messchendorp L, et al. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSKidney transplant recipients (KTRs) are still at risk of fatal COVID-19 disease after SARS-CoV-2 vaccination, even after a third booster vaccination. With the spread of new SARS-CoV-2 variants, great urgency exists for a better understanding of the factors that impact (...)
02:00
MO193: Capillary Point-Of-Care Creatinine Testing in Kidney Disease Patients - Rosset-Zufferey S, Emanuel Uehlinger D, Sidler D. Nephrol Dial Transplant

AbstractBACKGROUND AND AIMSCreatinine measurement is part of daily nephrological practice to estimate the glomerular filtration rate (eGFR). Creatinine is usually measured in plasma or in serum by the Jaffe method or enzymatic reactions [1]. New point-of-care testing (POCT) devices have been (...)

19 April

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

02:00
Correction to: Impact of pre-graft serology on risk of BKPyV infection post-renal transplantation Nephrol Dial Transplant

7 April

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

02:00
From WEDA to EDTA to ERA: 60 years of supporting European nephrology and counting - , Wanner C, Fliser D, et al. Nephrol Dial Transplant

25 March

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

01:00
Mechanisms of myostatin and activin A accumulation in chronic kidney disease - Bataille S, Dou L, Bartoli M, et al. Nephrol Dial Transplant

ABSTRACTBackgroundMyostatin and activin A induce muscle wasting by activating the ubiquitin proteasome system and inhibiting the Akt/mammalian target of rapamycin pathway. In chronic kidney disease (CKD), myostatin and activin A plasma concentrations are increased, but it is unclear if there is (...)

3 March

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

01:00
Design, recruitment, and baseline characteristics of the EMPA-KIDNEY trial - , Herrington W, Wanner C, et al. Nephrol Dial Transplant

ABSTRACTBackgroundThe effects of the sodium-glucose co-transporter 2 inhibitor empagliflozin on renal and cardiovascular disease have not been tested in a dedicated population of people with chronic kidney disease (CKD).MethodsThe EMPA-KIDNEY trial is an international randomized, double-blind, (...)

26 February

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

01:00
Nesfatin-1 treatment preserves antioxidant status and attenuates renal fibrosis in rats with unilateral ureteral obstruction - Tezcan N, Özdemir-Kumral Z, Özkan Yenal N, et al. Nephrol Dial Transplant

ABSTRACTBackgroundNesfatin-1 (NES-1), an anorexigenic peptide, was reported to have anti-inflammatory and anti-apoptotic actions in several inflammation models.MethodsTo elucidate potential renoprotective effects of NES-1, unilateral ureteral obstruction (UUO) was induced in male Sprague Dawley (...)

25 February

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

01:00
SGLT2 inhibitors and finerenone: one or the other or both? - Neuen B, Jardine M. Nephrol Dial Transplant

GambroBaxter10.13039/100004702Amgen10.13039/100002429Eli Lilly and Company10.13039/100004312Merck10.13039/100004334

23 February

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

01:00
European Renal Best Practice endorsement of guidelines for diagnosis and therapy of thrombotic thrombocytopaenic purpura published by the International Society on Thrombosis and HaemostasisA European Renal Best Practice (ERBP) endorsement of ISTH Guidelines for Treatment of Thrombotic Thrombocytopaenic Purpura (TTP) with some refinements for Europe - Eller K, Knoebl P, Bakkaloglu S, et al. Nephrol Dial Transplant

ABSTRACTThrombotic thrombocytopenic purpura (TTP) is a life-threatening disease that is caused by severe ADAMTS-13 deficiency. Immune-mediated TTP develops due to autoantibodies against ADAMTS-13, whereas congenital TTP is caused by mutations in the ADAMTS13 gene. Diagnostic possibilities and (...)

15 February

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

01:00
Erratum to: Access flow volume (Qa) and survival in a haemodialysis population: an analysis of 5208 Qa measurements over a 9-year period - Yadav R, Gerrickens M, van Kuijk S, et al. Nephrol Dial Transplant

10 February

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

01:00
Erratum to: Roxadustat for the treatment of anaemia in chronic kidney disease patients not on dialysis: A Phase 3, randomised, open-label, active-controlled study (DOLOMITES) - Barratt J, Andric B, Tataradze A, et al. Nephrol Dial Transplant
01:00
Erratum to: MO065 tubular epithelial cell polyploidization is required to survive AKI but promotes CKD development - De Chiara L, Lazzeri E, Angelotti M, et al. Nephrol Dial Transplant
01:00
Kidney health for all: bridging the gap in kidney health education and literacy - Langham R, Kalantar-Zadeh K, Bonner A, et al. Nephrol Dial Transplant

ABSTRACTThe high burden of kidney disease, global disparities in kidney care and poor outcomes of kidney failure bring a concomitant growing burden to those affected, their families, caregivers and the community at large. Health literacy is the degree to which people and organizations have or (...)

9 February

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

01:00
Heterologous versus homologous triple anti-COVID-19 vaccine regimens in patients on maintenance haemodialysis - Meijers B, Goedgezelschap A, Peeters D, et al. Nephrol Dial Transplant

8 February

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

01:00
Erratum to: Temporal changes and risk factors for death from early withdrawal within 12 months of dialysis initiation—a cohort study - Chen J, Brown M, Jose M, et al. Nephrol Dial Transplant

In the originally published version of this manuscript, there was an error in Figure 1. The arrow for ‘Early withdrawal mortality for medical reasons’ should originate from ‘Early withdrawal mortality’ instead of ‘Early non-withdrawal mortality’. This error has been (...)

7 February

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

01:00
Salt intake correlates with night systolic blood pressure in non-dialytic chronic kidney disease - Borrelli S, Mallamaci F, Chiodini P, et al. Nephrol Dial Transplant

Ministry of Health10.13039/100009647RF-2010–2314890

3 February

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

01:00
Erratum to: Relative risk versus absolute risk: one cannot be interpreted without the other - Noordzij M, van Diepen M, Caskey F, et al. Nephrol Dial Transplant

1 February

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

01:00
COVID-19 outbreak in vaccinated patients from a haemodialysis unit: antibody titres as a marker of protection from infection - Boudhabhay I, Serris A, Servais A, et al. Nephrol Dial Transplant

ABSTRACTBackgroundPatients on maintenance haemodialysis (HD) have an increased risk of severe coronavirus disease 2019 (COVID-19) and a reduced response to vaccines. Data are needed to identify immune correlates of protection in this population.MethodsFollowing a COVID-19 outbreak among (...)

29 January

Nephrol Dial Transplant http://ndt.oxfordjournals.org/

01:00
Association of diuretic use with increased risk for long-term post-transplantation diabetes mellitus in kidney transplant recipients - Sokooti S, Klont F, Tye S, et al. Nephrol Dial Transplant

ABSTRACTBackgroundPost-transplantation diabetes mellitus (PTDM) is a major clinical problem in kidney transplant recipients (KTRs). Diuretic-induced hyperglycaemia and diabetes have been described in the general population. We aimed to investigate whether diuretics also increase PTDM risk in (...)

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10 February

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29 January

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