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AbstractBACKGROUND AND AIMSData on the estimated glomerular filtration rate (eGFR) over time in older populations are scarce. Identifying patterns of eGFR progression is essential for a better understanding of chronic kidney disease (CKD) in older adults.METHODWe used data from the BIS, a (...)
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AbstractBACKGROUND AND AIMSTo date, associations between kidney function and brain structural abnormalities have been described in several studies [1]. Reports of renal function in relation to hippocampal atrophy have been scarce and the majority of studies have been focussed on older end-stage (...)
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AbstractBACKGROUND AND AIMSMammalian Protein Arginine Methyltransferase 1 (PRMT1) catalyzes the monomethylation and dimethylation of the Arginine residues of proteins. It has been shown that PRMT1 inhibitor attenuates renal fibrosis, however, the role of PRMT1 in renal interstitial fibrosis is (...)
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AbstractBACKGROUND AND AIMSDiabetic kidney disease (DKD) remains the most common cause of the end-stage renal disease (ESRD) worldwide. Kidney fibrosis predicts functional decline and ESRD in many, but not all patients [1]. Autotaxin (ATX) is the enzyme converting lysophosphatidylcholine to (...)
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AbstractBACKGROUND AND AIMSCardiovascular disease (CVD) and chronic kidney disease (CKD) are closely interrelated. Adverse immune responses have been implicated in the pathogenesis of both CVD and CKD [1, 2]. Monocyte subsets are key in atherogenesis and the inflammatory cascade occurring in (...)
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AbstractBACKGROUND AND AIMSThe actual definition of chronic kidney disease (CKD) applied to patients ?80 years has generated an increase in the number of referrals to Nephrology for consultation. Nowadays there is a debate about the evolution of kidney function in elderly patients, from (...)
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AbstractBACKGROUND AND AIMSProteinuria is a major risk factor for the progression of chronic kidney disease. Protein overload in the proximal tubular epithelial cells causes oxidative stress, lysosomal dysfunction, inflammation and apoptosis, resulting in proximal tubule dysfunction. Recent (...)
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AbstractBACKGROUND AND AIMSPartial nephrectomy (PN) has progressively replaced radical nephrectomy (RN) whenever feasible for renal tumors. However, its effects on renal outcomes are less known in patients with pre-existing chronic kidney disease (CKD) or with solitary kidney (SK). We aimed to (...)
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AbstractBACKGROUND AND AIMSKidney cortical interstitial fibrosis is highly predictive of renal prognosis and is currently assessed by the evaluation of a biopsy. Diffusion-weighted magnetic resonance imaging is a promising non-invasive tool to evaluate kidney fibrosis. We recently adapted a (...)
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AbstractBACKGROUND AND AIMSNovel ultrasound (US) methods are required to assess qualitative alterations in renal tissue. Superb microvascular imaging (SMI) is an innovative US technique designed for imaging and better visualization of micro-vascularization unseen with color Doppler US. We (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is a risk factor for cognitive impairment. In the general population, many risk factors have been reported in association with incident major neurocognitive disorders. The link between CKD and cognitive dysfunction is not completely (...)
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AbstractBACKGROUND AND AIMSAccumulating evidence has shown that chronic kidney disease (CKD) is associated with cancer development. However, the main focus in these studies was on patients with moderately or severely impaired kidney function, rather than on patients with milder CKD defined by (...)
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AbstractBACKGROUND AND AIMSLupus nephritis (LN) is the most common severe manifestation of systemic lupus erythematosus (SLE) and can lead to end-stage renal disease and death. However, there are limited data to contextualize the burden of LN in Germany, with no published studies using national (...)
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AbstractBACKGROUND AND AIMSIt is increasingly recognized that disparities in health care utilisation and associated clinical outcomes exist between men and women. Whether these sex disparities extend to patients with chronic kidney disease (CKD) is not well known. The primary goal of this study (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease (CVD) and death. Albuminuria has been identified as a risk factor, however, additional biomarkers predicting CKD progression and CVD are needed. Arterial stiffness is an easily (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) and inflammatory bowel disease (IBD) share many risk factors. While kidney complications are seen in 4%–23% of patients with longstanding IBD, it is unknown whether low kidney function may predispose to developing IBD.METHODWe analyzed the (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is a serious progressive disease with a substantial impact on global health that affects ?10% of the world's population. However, CKD remains largely under-recognized. Effective actions to slow disease progression and improve outcomes (...)
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AbstractBACKGROUND AND AIMSSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had a worldwide spread since early 2020 and a lot of studies concerning the diagnostic and prognostic role of chest computed tomography (CT) on coronavirus disease (COVID-19) has been published. Renal (...)
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AbstractBACKGROUND AND AIMSAKI is a common complication in critically ill patients, during the COVID-19 pandemic, it has been presented directly associated with damage by the virus, due to the severity of the disease and secondary to treatment, that is, secondary to the crosstalk of organs and (...)
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AbstractBACKGROUND AND AIMSEnhanced recovery after surgery (ERAS) protocol is an evidence-based programme that englobe more restrictive fluid therapy to maintain euvolemia and the use of multimodal analgesia, which includes non-steroidal anti-inflammatory drugs (NSAIDs). Consequently, it's (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a common complication of coronavirus disease-19 (COVID-19), which, particularly in critically ill patients requiring continuous renal replacement therapy (CRRT), is associated with an elevated mortality risk [1, 2]. However, knowledge (...)
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AbstractBACKGROUND AND AIMSRenal replacement therapy (RRT) is consensual in the presence of life-threatening complications associated with acute kidney injury (AKI). In the absence of urgent indications, the optimal timing for RRT initiation is still under debate. This systematic review with (...)
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AbstractBACKGROUND AND AIMSAcute interstitial nephritis (AIN) is one of the most frequent causes of acute kidney injury (AKI). Interstitial inflammation can lead to tubular epithelial infiltration producing tubular dysfunction, which could be clinically detected by glycosuria (with or without (...)
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AbstractBACKGROUND AND AIMSAKI is a common and serious post-operative complication in patients undergoing cardiac surgery, and its incidence is particularly high among elderly patients. Cardiac surgery-associated AKI (CSA-AKI) represents the second most common cause of AKI in the intensive care (...)
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AbstractBACKGROUNDStudies on acute kidney injury (AKI) in hematopoietic stem cell transplant (HSCT) consider several haematologic diagnoses in their cohorts and heterogeneous definitions for AKI not taking into consideration urinary output (UO). We aimed to evaluate the incidence and risk (...)
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AbstractBACKGROUND AND AIMSAcute kidney failure (AKI) is a well-known risk factor in coronary care unit (CCU) and postoperative patients. We aim to analyse their role in a multicentre database (DB) from a public regional health system (6 million inhabitants).METHODObservational, retrospective (...)
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AbstractBACKGROUND AND AIMSDuring the last 2 years, we have witnessed several waves of the COVID-19 pandemic characterized by massive infections among the general population, sudden increases in the number of hospitalizations and variable rates of complications and mortality among (...)
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AbstractBACKGROUND AND AIMSReaching a SCr ? 4 is one criterion of classification for stage 3 in the KDIGO-2012 AKI guidelines. No previous study has challenged this arbitrary cut point by comparing its performance on how patients with pure AKI (pAKI) versus acute on chronic kidney disease (...)
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AbstractBACKGROUND AND AIMSThe gold standard for measurement of protein excretion is a 24-h urine collection. However, due to the cumbersome nature as well as the frequent errors in sample collection, it has been suggested that the measurement of albumin-creatinine ratio (ACR) in a spot urine (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is a common problem in patients over 60 years of age. It´s necessary to control the administration of nephrotoxic drugs and to adjust the dosage of drugs eliminated by kidneys. Community pharmacists can improve risk stratification and (...)
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AbstractBACKGROUND AND AIMSEvaluation of urinary levels of the 11-dehydrothromboxane B2 is one of the methods for assessing platelet reactivity while taking aspirin. High levels of 11-dehydrothromboxane B2 in urine indicate continued thromboxane generation which is associated with an increased (...)
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AbstractBACKGROUND AND AIMSC57Bl6/J (B6) mouse strain is resistant to several experimental models of renal fibrosis. Mesangial cells play an important role in the pathogenesis of glomerulosclerosis. Also, autophagy dysregulation was recently related to fibrosis. However, it is unclear whether (...)
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AbstractBACKGROUND AND AIMSThe use of tools that allow to estimate the probability of progression of chronic kidney disease (CKD) to advanced stages, has not yet gained a notable space in our clinical practice. The aim of this study was to develop and validate a model to predict disease (...)
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AbstractBACKGROUND AND AIMSRenal fibrosis is one of the pathological hallmarks of chronic kidney disease (CKD) that can further progress to end-stage renal diseases (ESRD). Haemodialysis and kidney transplantation are the only feasible treatments of ESRD. In this study, a new treatment with (...)
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AbstractBACKGROUND AND AIMSThe SARS-COV-2 acute respiratory distress fyndrome, which is the source of the infection known as coronavirus disease (COVID-19), spread rapidly, causing a pandemic that not only severely affected human health but also restricted the activities of daily living and (...)
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AbstractBACKGROUND AND AIMSKidneys play a primary role in electrolyte homeostasis. The association between serum sodium level and mortality or the need for kidney replacement therapy during acute kidney injury has not been adequately explored.METHODIn this prospective cohort study, we enrolled (...)
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AbstractBACKGROUND AND AIMSKuwait enjoys a cool winter but suffers a very hot summer. We aim to evaluate the relationship between weather temperature and acute kidney injury (AKI) incidence and outcome.METHODWe prospectively collected demographic (age, sex and nationality), clinical (CKD (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AK) is a frequent condition in patients hospitalized for COVID-19. There are only few reports on the use of urinary biomarkers in COVID-19 and no data comparing the prognostic use of individual biomarkers in the prediction of adverse outcome so (...)
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AbstractBACKGROUND AND AIMSDuring a 2-year pandemic, COVID-19 proved to be a condition with a high potential to affect various organs other than the lungs. Acute kidney injury (AKI) in hospitalized COVID-19 patients is associated with a poor prognosis. The aim of this study was to identify (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) and acute kidney disease (AKD), a typical inpatient disease spectrum, pose an exceptional burden on the current healthcare system worldwide. By contrast, developing operative diagnostic criteria for AKD in the outpatient setting (AKDOPT) (...)
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AbstractBACKGROUND AND AIMSAcute kidney disease (AKD), the condition of which acute kidney injury (AKI) has not recovered, is being emphasized because it increases the risk of progression to chronic kidney disease (CKD). Post-operative AKI (PO-AKI) is a common clinical setting prone to develop (...)
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AbstractBACKGROUND AND AIMSCurrent Glomerular filtration rate (GFR) estimating equations based on serum creatinine are facing increased criticism due to the inclusion of a race correction in black Americans with the CKD-EPI equation (CKD-EPIASR, A = Age, S = Sex, R = Race). A new equation (...)
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AbstractBACKGROUND AND AIMSCurrently >20 000 native peptides in urine are known that are highly dynamic and able to display the status of different organs, especially the kidney. The characterization of urinary peptide profiles (UPP) enables the depiction of kidney disease severity, (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) alters renal haemodynamics, leads to tubular injury, activates pathways of inflammation, proliferation and cell death. The initial damage caused by ischaemia/reperfusion injury (IRI) plays an important role in the pathogenesis of the AKI and (...)
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AbstractBACKGROUND AND AIMSAlbeit the association between renal disorders and celiac disease is still somewhat contradictory, an elevated risk of kidney diseases in patients with celiac disease has been shown [1, 2, 3]. Only case reports have described the link between glomerulonephritis and (...)
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AbstractBACKGROUND AND AIMSUrea excretion is the basic function of the nephron. However, its prognostic implication has been not extensively studied in a specific subpopulation of chronic kidney diseases (CKD).METHODTotal of 2232 patients in KNOW-CKD cohort were analyzed. Baseline (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) patients present an increased plasma level of protein-bound solutes known as uraemic toxins. Their accumulation is associated with, amongst others, cardiovascular events. The gut microbiome plays an important role in the generation of part (...)
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AbstractBACKGROUND AND AIMSIn a previous work we have found that there is a reduction in urinary citrate levels in autosomic dominant polycystic kidney disease (ADPKD) patients. Their levels are related to GFR but not serum bicarbonate levels. Our aim was to analyse whether there is any (...)
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AbstractBACKGROUND AND AIMSCopper is an essential trace element for eukaryotes and a vital cofactor for various enzymes for a multiplicity of functions. Our previous study indicated that intracellular copper overload plays an important role in renal fibrosis. However, the underlying mechanism (...)
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AbstractBACKGROUND AND AIMSThe risk of developing tuberculosis (TB) is 10–25% in chronic kidney disease (CKD) patients. TB in CKD patients may have a mortality of 16–37%. Standard treatment with four drugs (Isoniazid, Rifampin, Pyrazinamide and Ethambutol) predisposes to side effects, drug (...)
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AbstractBACKGROUND AND AIMSA child with end-stage renal disease (ESRD) hopes for a kidney transplant to avoid dialysis. Despite the recent priority rules for assigning transplants to children. Most of them, due to their young age, the time required to prepare for the transplant, and especially (...)
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AbstractBACKGROUND AND AIMSThere is an increasing number of patients with advanced chronic kidney disease (CKD) who are older, frail, with multi-morbidity, and with poor functional status. Renal palliative medicine or kidney supportive care is an evolving branch of nephrology. In medicine, (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is a major public health problem. CKD constitutes a complex disease due to differing underlying disease etiologies in each patient, which can in turn lead to many complications, comorbidities and polypharmacy. Monitoring disease (...)
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AbstractBACKGROUND AND AIMSSocial disparities in chronic kidney disease (CKD) are a reality. Low socioeconomic status is associated with an increased incidence of CKD and overall worse outcomes. In Portugal, similarly to many European countries, a National Health System (NHS) was established to (...)
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AbstractBACKGROUND AND AIMSThe global burden of chronic kidney disease (CKD) is growing, impacting around 10% of the worldwide population becoming the 5th cause of mortality by 2023, with high cost for the health care system (Glassrock et al. 2017). CKD can be identified using two easy and (...)
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AbstractBACKGROUND AND AIMSDuring the COVID-19 pandemic, patients on maintenance heamodialysis (HD) are vulnerable due to their comorbidities, uremia-impaired immunity and limited physical distancing. We aimed to evaluate the risk factors and outcomes of SARS-CoV-2 infection in HD patients in (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is a worldwide health problem whose incremental prevalence. Early detection and proper monitoring of renal dysfunction can decrease morbidity and mortality among CKD patients. Estimated glomerular filtration rate (eGFR) and albuminuria (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a frequent and serious complication in critically ill patients admitted in intensive care unit (ICU). The development of acute kidney damage is associated with various adverse outcomes, such as prolonged stay in the ICU, the development of (...)
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AbstractBACKGROUND AND AIMSAcute interstitial nephritis (AIN) is a common cause of acute renal failure affecting between 5% and 27%. It is characterized by the presence of interstitial inflammatory infiltrate, tubulitis and edema. A considerable number of cases develop chronic kidney disease (...)
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AbstractBACKGROUND AND AIMSAtypical haemolytic uremic syndrome (aHUS) is a form of thrombotic microangiopathy (TMA) associated with dysregulation of the alternative complement pathway [1]. It is characterized by microangiopathic haemolytic anaemia, thrombocytopenia and acute kidney injury [1]. (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is commonly associated with an adverse outcome in hospitalised patients. Frailty and comorbidity are risk factors for acute kidney injury. The aim of this study was to assess the strength of association between frailty and comorbidity as (...)
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AbstractBACKGROUND AND AIMSKidneys play a primary role in potassium homeostasis. The association between potassium (sK+) level and mortality or the need for kidney replacement therapy (KRT) during acute kidney injury (AKI) has not been adequately explored.METHODIn this prospective cohort study, (...)
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AbstractBACKGROUND AND AIMSImmune checkpoint inhibitor (ICI) therapy has improved the outcome of advanced melanoma but can also lead to kidney injury. Anti-programmed cell death protein 1 (anti-PD-1) therapy is now used in adjuvant setting for stage 3 melanoma after curative intent surgery, and (...)
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AbstractBACKGROUND AND AIMSWithin the Veterans Health Administration, the largest integrated healthcare system in the USA, 1.1 million Veterans (16.4%) have been identified as having chronic kidney disease (CKD). Annual spending on US Veterans with non-dialysis dependent CKD is estimated at $19 (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a common complication among patients hospitalized with COVID-19. The incidence of AKI is estimated to be around 5%–80%, according to the series, but data on renal function evolution is limited. Our main objective was to describe the (...)
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AbstractBACKGROUND AND AIMSCoronavirus disease 2019 (COVID-19), which started in China in December 2019 and spread all over the world, is more progressive in patients who are elderly and with chronic diseases. Especially, kidney involvement affects the survival of patients. In this study, we (...)
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AbstractBACKGROUND AND AIMSEvidence exists that inflammation plays an important role in the pathogenesis of acute kidney injury (AKI) in sepsis patients. Haematological ratios can be used to measure systemic and silent inflammation. Therefore, we investigated what haematological ratios could be (...)
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AbstractBACKGROUND AND AIMSDespite the lungs are the major targets of COVID-19, other organs such as the kidneys are also affected. Renal complications of COVID-19 are not yet well studied. We aimed to study the prevalence of acute kidney injury (AKI) among positive COVID-19 cases that were (...)
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AbstractBACKGROUND AND AIMSCoronavirus disease 2019 (COVID-19) is mainly an infectious disease of the respiratory system transmitted through air droplets, and pulmonary symptoms constitute the main presentations of this disease [1]. The first cases of the disease were identified in Wuhan, (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI), frequently with concurrent albuminuria and haematuria, is common and increases mortality in COVID-19 infection. We present the clinical course and long-term outcomes of COVID-19 survivors with AKI and continuous kidney replacement therapy (...)
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AbstractBACKGROUND AND AIMSElevated uric acid (UA) is associated with comorbidities such as hypertension, diabetes, cardiovascular disease and chronic kidney disease. There are more studies that discuss the importance of uric acid (UA) for acute kidney failure. Anaemia is a common risk factor (...)
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AbstractBACKGROUND AND AIMSKidney failure is the second most frequent condition after acute respiratory distress syndrome (ARDS) in critically ill patients with severe COVID-19 and is strongly associated with mortality. The aim of this multicentric study was to assess the impact of the specific (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a potential complication of COVID-19 and the hypercoagulation tendency of SARS-CoV-2 infection is considered one of the underlying mechanisms. Fibrinolysis markers have been described as severity parameters, independent of clinically (...)
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AbstractBACKGROUND AND AIMSLiver transplantation is a mandatory treatment for many cirrhotic patients worldwide. Nonetheless, frequently there is high systemic morbidity and considerable mortality in post transplantation [1].Our aim was to calculate acute kidney injury incidence (KDIGO), need (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) has been described as a frequent complication in patients with COVID-19. The incidence of AKI is estimated to be around 5%–80% depending on the series; however, data characterizing the type of AKI and the evolution of renal function parameters (...)
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AbstractBACKGROUND AND AIMSCurrent Glomerular filtration rate (GFR) estimating equations based on serum creatinine are facing increased criticism due to the inclusion of a race correction in black Americans with the CKD-EPI equation (CKD-EPIASR, A = Age, S = Sex, R = Race). New equations (...)
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AbstractBACKGROUND AND AIMSMeasurement of glomerular filtration rate (GFR) is a cumbersome, time consuming, and expensive process, thus estimated GFR (eGFR) has become a commonly accepted surrogate or screening tool for individuals suspected to have kidney disease. Until recently this required (...)
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AbstractBACKGROUND AND AIMSApproximately 40% of people with type 2 diabetes (T2D) develop chronic kidney disease (CKD) and, despite current treatment, T2D is the most common cause of progression to kidney failure. This situation underscores the need for additional pharmacotherapeutic options. (...)
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AbstractBACKGROUND AND AIMSRenal artery stenosis causes hypertension in 10–40% of severe cases or refractory to treatment. As a gold standard test for its diagnosis, we have arteriography, which allows the interventional therapeutic option, through angioplasty and/or stenting. There is no (...)
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AbstractBACKGROUND AND AIMSWith a global expansion of the elderly population, physicians encounter a growing number of chronic kidney disease (CKD) patients who have no or only a minimal amount of proteinuria. However, those patients are not clinically uniform; some quickly develop into a (...)
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AbstractBACKGROUND AND AIMSUraemic toxins accumulate in the blood and tissues of patients with chronic kidney disease (CKD). Previous animal studies have shown that chronic kidney disease (CKD) not only alters the elimination of drugs excreted by the kidneys, but it also impacts the metabolism (...)
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AbstractBACKGROUND AND AIMSObstructive anuria is defined as a total cessation of diuresis or a volume of METHODFrom January 2018 to December 2020, we conducted a 3-year retrospective and descriptive study of patients treated at the CHU IBN ROCHD of Casablanca's nephrology and haemodialysis (...)
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AbstractBACKGROUND AND AIMSFew studies have investigated the physiological alterations provoked by ultramarathon competition, particularly those related to redox balance, kidney function and NGAL regulation. A better understanding of the dynamics of these biomarkers during ultramarathons could (...)
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AbstractBACKGROUND AND AIMSLimited data exists on acute kidney injury (AKI) in patients hospitalized with COVID-19, its risk factors and associated outcomes from low-middle income countries. We aimed to determine the epidemiology of AKI and its impact on outcomes at a tertiary-care center in (...)
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AbstractBACKGROUND AND AIMSOne of the complications described in critically ill patients in intensive care units with severe COVID-19 was acute kidney injury (AKI). The pathophysiology of AKI in patients with COVID-19 is multifactorial. In addition to the direct virulence of SARS-CoV-2 in renal (...)
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AbstractBACKGROUND AND AIMSMicrocirculation plays a critical role in the development of sepsis-associated acute kidney injury (S-AKI); however, it remains uncertain whether microcirculatory dysfunction influences recovery. We investigated the association of contrast-enhanced ultrasound (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a common complication in patients affected by coronavirus disease-19 (COVID-19) and its development is associated with high mortality [1]. However, it is also clear that the COVID-19 pandemic has effects on the management of diseases not (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a common complication in allogeneic stem cell transplantation (SCT). Although short-lived, i.e. < 90 days, in the majority of patients renal injury can persist for more than 3 months fulfilling the criteria of chronic kidney disease (...)
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AbstractBACKGROUND AND AIMSIn order to identify behavioral, environmental, biological or genetic determinants of kidney function, population-based epidemiological studies rely on approximate estimates of the glomerular filtration rate (eGFR) based on measured markers such as serum creatinine, (...)
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AbstractBACKGROUND AND AIMSDiabetic nephropathy (DN) is the common cause of end-stage renal disease. However, the early and specific diagnostic biomarkers are still lacking. Urinary exosomes are a potential source of biomarkers for kidney disease due to their renal cell origination, stability, (...)
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AbstractBACKGROUND AND AIMSA cytokine storm drives the pathogenesis of severe coronavirus disease (COVID-19) and several biomarkers with different mechanisms of action have been linked to mortality. Chronic kidney disease (CKD) emerged as a very common risk factor for severe COVID-19. Indeed, (...)
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AbstractBACKGROUND AND AIMSThe incidence of acute renal failure (ARF) is frequent and has an implication in the morbidity and mortality of SARS-CoV-2 infection.METHODA retrospective descriptive study of patients admitted for SARS-CoV-2 infection during the first (G1) and second (G2) waves who (...)
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AbstractBACKGROUND AND AIMSLeptospirosis is a global zoonotic bacterial disease that may cause life-threatening complications, such as acute kidney injury (AKI). Patients with AKI may recover fully, but some can progress to chronic kidney disease (CKD) or even become dialysis-dependent. This (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a prevalent complication among hospitalized patients worldwide and is associated with a high morbidity and mortality rate. The SEA-MAKE score is a scoring tool recently introduced to predict major adverse kidney events (MAKE), defined as (...)
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AbstractBACKGROUND AND AIMSLeptospirosis is an endemic, globally widespread zoonotic disease caused by pathogenic spirochetes of the genus Leptospira. It presents with high clinical variability, with a constellation of symptoms ranging from a mild, nonspecific, self-limiting febrile syndrome to (...)
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AbstractBACKGROUND AND AIMSThe incidence of acute kidney injury following cardiac surgery (CSA-AKI) is up to 30% and it places patients at an increased risk of death. Leicester score (LS) is a new score designed by Birnie et al. [1] and validated in 2014 in a British Cohort. It predicts CSA-AKI (...)
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AbstractBACKGROUND AND AIMSThe acute effects of the acute kidney injury (AKI) on short-term mortality in patients with novel coronavirus infection (COVID-19) have been studied, but the long-term outcomes after COVID-19-associated AKI are not well understood. Our aim was to evaluate the impact (...)
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AbstractBACKGROUND AND AIMSDuring COVID-19, the renal impairment is the most frequent after lung impairment and is associated of poor prognosis particularly in the intensive care unit (ICU). In this work, we aim to assess the incidence of acute kidney injury (AKI) in COVID-19-related acute (...)
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AbstractBACKGROUND AND AIMSThe gold standard for evaluation of kidney function is measured GFR [mGFR] which is challenging to perform in clinical practice. Serum creatinine and cystatin C are used to estimate GFR clinically, but neither is a perfect marker. Within any given individual, the (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease affects up to 15% of adults, current diagnostic methods for assessing kidney health and early detection of renal disease lack sensitivity and/or can be highly invasive. The kidney sheds cells into the urine and harvesting these cells and their (...)
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AbstractBACKGROUND AND AIMSSeveral studies demonstrate that klotho shows renoprotective actions. However, it has not been assessed whether klotho supplementation is able to reverse the renal injury.METHODIn the present study, the effects of klotho protein supplementation on remnant rat kidneys (...)
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AbstractBACKGROUND AND AIMSTobacco is a risk factor for some cardiovascular and respiratory diseases, as well as for the development of some tumours. Furthermore, new research has shown evidence of the risk that smokers have of developing kidney disease [1]. On the other hand, biomarkers used (...)
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AbstractBACKGROUND AND AIMSFavorable skeletal muscles have been associated with higher physical activity (PA) in the general population. However, little is known regarding this relationship in a population of Chinese chronic kidney disease (CKD) patients. The aim of this study is to investigate (...)
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AbstractBACKGROUND AND AIMSSGLT2 inhibitors have been shown to reduce kidney and cardiovascular events and slowing the decline of renal function in chronic kidney disease. We have examined the effect of SGLT2 inhibition in our cohort of ambulatory patientsMETHODWe have included patients with (...)
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AbstractBACKGROUND AND AIMSObesity is a major global problem affecting more than 1.9 billion adults [1]. The aetiological factors of obesity are complex and consist of genetic, social and environmental elements. Obesity can lead to chronic kidney disease (CKD) via both direct and indirect (...)
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AbstractBACKGROUND AND AIMSIgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. We have previously shown that patients with assumed benign IgAN can develop progressive kidney failure, including end-stage kidney disease, after a sufficiently long follow-up period [1]. (...)
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AbstractBACKGROUND AND AIMSDietary phosphate intake greatly exceeds the recommended daily allowance in the Western population. Elevated phosphate levels are linked to increased cardiovascular and all-cause mortality, impaired bone health and premature ageing. The renal effects of chronic high (...)
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AbstractBACKGROUND AND AIMSMutations in PKD1 or PKD2 gene, which encodes polycystin-1 or polycystin-2, cause autosomal polycystic kidney disease (ADPKD). The development of ADPKD is associated with the progression of renal fibrosis. Whether renal fibrosis in ADPKD is a direct effect of PKD (...)
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AbstractBACKGROUND AND AIMSIt is unclear whether hematuria is a risk factor for chronic kidney disease (CKD) progression. In addition, quantitative evaluation considering urine concentration as in proteinuria has not been established in hematuria. The aim of this study is to verify the (...)
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AbstractBACKGROUND AND AIMSCoding of chronic kidney disease (CKD) is associated with better outcomes through addressing the risk factors, and CKD-coded cases were found to have fewer unplanned hospital admission rates.We aim to compare the CKD coding across Hertfordshire and West Essex to the (...)
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AbstractBACKGROUND AND AIMSIndividuals living with chronic kidney disease (CKD) are at greater risk of sustaining hip fractures compared with the general population. Following acute trauma, CKD patients are susceptible to lengthened hospitalization with their clinical condition exacerbated by (...)
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AbstractBACKGROUND AND AIMSRecent data have proven that NAFLD (nonalcoholic fatty liver disease) and NASH (nonalcoholic steatohepatitis) increase the risk of CKD. Changing the concept of NAFLD to MAFLD (metabolic dysfunction associated fatty liver disease) changes the data of inclusion of (...)
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AbstractBACKGROUND AND AIMSNowadays, end-stage renal disease (ESRD) is overrepresented in elderly patients. The presence of medical comorbidities, limited life expectancy, frailty and poor functional status in these patients poses substantial challenges in clinical decision-making and provision (...)
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AbstractBACKGROUND AND AIMSPatients on kidney replacement therapy (KRT) are at a particularly high risk of mortality from COVID-19. In this study, we investigated COVID-19 mortality in KRT patients in the first and second waves of the pandemic and potential reasons for any difference in (...)
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AbstractBACKGROUND AND AIMSElevated serum urea levels are common in moderate-to-advanced CKD. Several studies have shown that urea is a direct and indirect uremic toxin, especially with regard to cardiovascular disease. We sought to determine whether serum urea levels are associated with (...)
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AbstractBACKGROUND AND AIMSAll researchers dealing with Balkan endemic nephropathy (BEN) talk about the association of BEN with malignant tumours of the upper urothelium (UTUC). Long-term research of UTUC obtained various results depending on the period and region of observation, depending on (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is a growing global public health burden among aging populations and is associated with increased risks of cardiovascular disease, kidney failure and death. Early identification and treatment can amelioriate these risks. We aimed to (...)
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AbstractBACKGROUND AND AIMSMen are at higher risk of cardiovascular disease (CVD) than women in the general population, and chronic kidney disease (CKD) is a well-established cardiovascular (CV) risk factor [1–4]. However, the incidence of cause-specific CV events in men and women with CKD is (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) has been recognized as a highly prevalent risk factor for both the severity of coronavirus disease 2019 (COVID-19) and COVID-19 associated adverse outcomes. In this multicentre observational cohort study, we aim to determine the mortality (...)
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AbstractBACKGROUND AND AIMSHeart rate variability (HRV), reflecting the circadian rhythm of heart rate, is associated with clinical outcomes in stage 5 chronic kidney disease 5 (CKD5) patients. Whether CKD-related factors combined with HRV can improve the predictive ability for their death (...)
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AbstractBACKGROUND AND AIMSLithium is an established treatment for bipolar disorder and treatment-resistant depression. Despite awareness of potential kidney damage, there is a lack of research evidence to inform on the existence and magnitude of the risk. Observational studies to date show (...)
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AbstractBACKGROUND AND AIMSBefore the onset of renal failure in idiopathic membranous nephropathy (MN), the role of certain histological factors in the progressive loss of renal function are still poorly understood. The present study examined the relationship between glomerular density (GD: (...)
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AbstractBACKGROUND AND AIMSSymmetric dimethylarginine (SDMA) is regarded as an independent cardiovascular risk factor in patients with chronic kidney diseases. Renal interstitial fibrosis is a common pathway of all kinds of chronic kidney diseases progressing to the end-stage of renal diseases. (...)
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AbstractBACKGROUND AND AIMSRecently, a growing number of studies have reported a close relationship between high serum calcium and low serum magnesium with vascular calcification. Endothelial dysfunction and vascular inflammation seem plausible risk factors for enhanced progression of kidney (...)
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AbstractBACKGROUND AND AIMSHeart failure (HF) is a clinical problem highly prevalent in the general population (1–2%) and much more so among patients with chronic kidney disease (CKD) (17–21%). The left ventricular assist device (LVAD) is a type of mechanical circulatory support device (MCSD) (...)
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AbstractBACKGROUND AND AIMSCardiovascular diseases (CVD) and chronic kidney diseases (CKD) are highly prevalent in Western populations and account for a substantial proportion of mortality. We recently found that apolipoprotein C-3 (ApoC3), a constituent of triglyceride-rich lipoproteins, (...)
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AbstractBACKGROUND AND AIMSVascular calcification is a clinical sequelae of chronic kidney disease (CKD) that is associated with high cardiovascular-related mortality in end-stage kidney failure (ESKF) patients. Increased senescent cell burden and dysregulation of the NRF2 pathway, the master (...)
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AbstractBACKGROUND AND AIMSNon-communicable diseases (NCDs) are rapidly emerging as a major cause of chronic kidney disease (CKD) in Africa with a reported prevalence of 10.7% locally. At current, few high-quality studies assessing the epidemiology of CKD in South Africa have been published. (...)
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AbstractBACKGROUND AND AIMSPatients with end-stage renal disease (ESRD) have complex functional and social changes that affect their quality of life (QoL), leading to an increased cardiovascular risk, mortality and overall morbidity. Several studies showed that general QoL worsened after (...)
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AbstractBACKGROUND AND AIMSBiopsies are a diagnostic tool for the diagnosis of histopathological, molecular biological, proteomic and imaging data, to narrow down disease patterns or identify diseases. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) provides an (...)
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AbstractBACKGROUND AND AIMSSarcopaenia, defined as the loss of muscle mass and function, is an ageing-related pathology associated with some important diseases such as chronic kidney disease (CKD). Hyperphosphatemia has been associated with both, ageing and CKD. Old mice show an increase in (...)
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AbstractBACKGROUND AND AIMSThe canonical Wnt (cWnt) is known to be involved in tubular recovery after kidney injury and fibrosis, while arterial hypertension (AH) promotes cWnt activity. The aim of the study was to investigate the kidney expression of ?-catenin and cWnt inhibitors in AH and (...)
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AbstractBACKGROUND AND AIMSMetabolic acidosis (HCO3 < 22 mmol/L) is associated with an increased hazard of death in patients with chronic kidney disease (CKD) [1, 2]. It is further associated with muscle wasting, bone disease, hypoalbuminemia, increased inflammation, protein malnutrition, (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease-associated pruritus (CKD-aP) is frequently reported by patients with CKD undergoing haemodialysis (HD), impacting sleep quality, quality of life and depression. Difelikefalin is a selective kappa-opioid receptor agonist approved in the United (...)
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AbstractBACKGROUND AND AIMSPhysical activity (PA) is widely recommended for the prevention of chronic conditions including cardiovascular (CV) disease. In chronic kidney disease (CKD), it is unclear whether PA confers a similar benefit. We examined whether the duration and intensity of PA are (...)
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AbstractBACKGROUND AND AIMSRenal fibrosis is a central feature of chronic kidney disease (CKD), and the severity of CKD correlates with the magnitude of renal fibrosis. Despite the causative role attributed to fibrosis in CKD progression, there is still no treatment available that directly (...)
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AbstractBACKGROUND AND AIMSThe coronavirus disease 2019 (COVID-19) has affected our patients not only in renal replacement therapy (RRT), but also in advanced chronic kidney disease (ACKD) consultation. Our aim is to assess the impact of COVID-19 in a group of patients of our ACKD (...)
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AbstractBACKGROUND AND AIMSMonoclonal gammopathy of undetermined significance (MGUS) has a high prevalence in the elderly population, being as high as 9% in subjects over 85 years. Population aging leads to an increase in the number of patients with MGUS. In 2012, monoclonal gammopathy of renal (...)
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AbstractBACKGROUND AND AIMSIt has been postulated that the protein-creatinine ratio in spot urine sample (uPCR) could be an adequate alternative to measurement of proteinuria in 24-h urine samples (24-h proteinuria), which despite being the gold standard for the diagnosis and follow-up of (...)
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AbstractBACKGROUND AND AIMSIn view of the fact that the human microbiota varies depending on many factors, including comorbid pathology, it seems reasonable to investigate the intestinal microbiota in patients with chronic kidney disease and its likely relationship with markers of systemic (...)
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AbstractBACKGROUND AND AIMSIn the Kidney Disease Improving Global (KDIGO) guidelines, it is recommended that an accurate chronic kidney disease (CKD) diagnosis is based on repeated positive test results for estimated glomerular filtration rate (eGFR) and urine albumin-to-creatine ratio (UACR). (...)
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AbstractBACKGROUND AND AIMSUrine albumin-to-creatinine ratio (ACR) and protein-to-creatinine ratio (PCR) are used to measure urine protein. Recent guidelines recommend the use of the ACR, and equations have been developed incorporating ACR to predict risk of kidney failure. Where ACR cannot be (...)
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AbstractBACKGROUND AND AIMSGlobally, diabetes mellitus is a leading cause of kidney disease, with a critical % of patients approaching end-stage kidney disease. At the same time, chronic kidney disease (CKD) is a major contributor to illness and is associated with impaired quality of life. (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease of unknown etiology (CKDu) has been a critical health issue among the farming communities of Sri Lanka for decades [1]. However, the distribution of CKDu in Sri Lanka is geographically significant by representing endemicity on its own [2]. This (...)
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AbstractBACKGROUND AND AIMSLeucine-rich alpha-2-glycoprotein (LRG1) is a novel proangiogenic factor involved in the abnormal angiogenesis and renal fibrosis in diabetic nephropathy by potentiating endothelial transforming growth factor-beta/activin receptor-like kinase 1 (TGF-?/ALK1) signalling (...)
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AbstractBACKGROUND AND AIMSTobacco consumption is associated with cancer, cardiovascular and respiratory diseases. Although new research relates tobacco use with the development of kidney damage, classic biomarkers, such as plasma creatinine, are not useful to detect this kidney injury [1]. In (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) and diabetes are both well-established risk factors for cardiovascular mortality. However, the risk of cardiovascular mortality and the impact of diabetes for those who have already reached advanced CKD are poorly examined. We examined the (...)
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AbstractBACKGROUND AND AIMSIntramyocardial arteries (IA) are one of the components of pathological cardiac remodeling. We have previously shown that cardiomyocytes hypertrophy and interstitial fibrosis are accompanied by calcineurin (CaN) and ?-catenin (?Cat) up-regulation in the model of (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a global health concern associated with high morbidity and mortality, as well as a high risk of progression to chronic kidney disease (CKD). As a result of phenotype diversity and plasticity, macrophages are recognized as key regulators of (...)
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AbstractBACKGROUND AND AIMSSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been in our daily practice for almost 2 years now. Since the beginning of the pandemic, we have aimed to study its most immediate effects on patients to find the best line of treatment or, at (...)
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AbstractBACKGROUND AND AIMSThe acute effects of the novel coronavirus infection (COVID-19) on short-term kidney outcomes have been studied, the long-term kidney outcomes after COVID-19-associated acute kidney injury (AKI) in comparison with hospitalized patients without AKI are insufficiently (...)
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AbstractBACKGROUND AND AIMSIn the early stages of sepsis, the renin–angiotensin–aldosteron system (RAAS) is activated despite adequate volume resuscitation. Overactivity of RAAS might contribute to an inferior outcome in patients with severe sepsis, therefore modulation of RAAS could be (...)
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AbstractBACKGROUND AND AIMSCollagen is a major component of the extracellular matrix (ECM) and has an essential role in the onset and progression of fibrosis and chronic kidney disease (CKD). Collagen alpha-1(I) (col1a1) is the most abundant collagen type in humans and the involvement of (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is an escalating global health concern, and non-invasive means for early CKD detection is eagerly awaited. Kidneys are water- and electrolytes-rich organs with good bio-conductivity. Kidney fibrosis and tubular atrophy are characteristic (...)
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AbstractBACKGROUNDCoronavirus disease (COVID-19) infection by severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) virus is an ongoing pandemic with high morbidity and mortality rates. The second COVID-19 wave was observed between April–July 2021. Patients with underlying CKD, ? 65 years, (...)
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AbstractBACKGROUND AND AIMSNon-alcoholic fatty liver disease (NAFLD) is suggested as being a risk factor for chronic kidney disease (CKD). The incidence of NAFLD is rising globally parallel to the increasing incidences of obesity and type 2 diabetes. As diabetes remains the leading cause of CKD (...)
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AbstractBACKGROUND AND AIMSPostoperative atrial fibrillation (POAF) is a frequent arrhythmic complication in cardiac surgery. Studies of this potential complication have not been able to elucidate its aetiology nor to identify the predictors of its occurrence. The aim of this study was to (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease-associated pruritus (CKD-aP) is a common condition in patients with CKD undergoing haemodialysis (HD), leading to poor sleep quality, reduced quality of life and depression. Difelikefalin is a selective kappa opioid receptor agonist approved in (...)
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AbstractBACKGROUND AND AIMSStatins, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, are primarily cholesterol-lowering drugs that have become standard of care in the primary and secondary prevention of cardiovascular diseases. Apart from lipid-lowering, statins may act beneficially (...)
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AbstractBACKGROUND AND AIMSThe pathogenesis of low-birth-weight (LBW)-related nephropathy has been considered to be the result of intra-glomerular hyperfiltration during growth due to the presence of low nephron numbers. On the other hand, we hypothesized that there may be pathogenic factor(s) (...)
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AbstractBACKGROUND AND AIMSThe objective of this observational study was to describe the `DAPA-CKD-like’ population and to assess the burden of illness (comorbidities, cardiovascular (CV) and renal events) and prognosis in patients with CKD in France, compared with those randomized in the (...)
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AbstractBACKGROUND AND AIMSEnd-stage chronic renal disease (ESRD) is an irreversible disease with serious consequences for the life of the patient and perceived as a social and professional handicap. Management of ESRD therefore requires not only control of symptoms and morbidity, but also (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is a significant cause of morbidity, cardiovascular and all-cause mortality. CHA2DS2VASc is a score system used in patients with atrial fibrillation to predict thromboembolic risk. However, it also appears to be useful to predict mortality (...)
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AbstractBACKGROUND AND AIMSANCA-associated vasculitis (AAV) refers to a group of conditions in which the end result is systemic injury of small blood vessels, resulting in damage to distinct organ systems including the lung, kidneys, ear, nose and throat. A characteristic, although not (...)
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AbstractBACKGROUND AND AIMSRenal recovery (RR) after AKI is a determinant outcome of future comorbidity and mortality in critical care patients. Related predictive factors remain uncertain.METHODWe retrospectively analyzed patients admitted to ICU between January 2020 and February 2021 from our (...)
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AbstractBACKGROUND AND AIMSLower antibody responses after SARS-Cov-2 vaccination have been reported in patients with severely impaired kidney function or patients with kidney replacement treatment. We compared humoral responses and reported adverse events of three vaccines (mRNA-1273, BNT162b2 (...)
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AbstractBACKGROUND AND AIMSThe Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend regular estimated glomerular filtration rate (eGFR) and albuminuria testing in patients diagnosed with chronic kidney disease (CKD) and those with specific risk factors such as type 2 diabetes (...)
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AbstractBACKGROUND AND AIMSRegular estimated glomerular filtration rate (eGFR) and albuminuria testing in patients diagnosed with chronic kidney disease (CKD) and those with specific risk factors such as type 2 diabetes is recommended in The Kidney Disease Improving Global Outcomes (KDIGO) (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is a highly predominant worldwide disease, representing an enormous economic burden with profound social implications. In addition to frequent infections and mineral and bone disorders, CKD patients also experience exacerbated mobility (...)
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AbstractBACKGROUND AND AIMSVascular calcification is one major complication in patients with chronic kidney disease (CKD), with a misbalance in calcium and phosphate metabolism playing a crucial role. The mechanisms underlying vascular calcification have not been entirely revealed to date. As (...)
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AbstractBACKGROUND AND AIMSThe role of cardiac biomarker, NT-pro-BNP and its rising over time may identify chronic kidney disease (CKD) patients at increased risk of cardiovascular morbidity and mortality. Additionally, this may be correlated with altered cardio-metabolic risk factors (...)
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AbstractBACKGROUND AND AIMSSalvianolic acid C (SAC) is a component of Danshen, a widely used herbal medicine for the treatment of renal cardiovascular diseases. Renal interstitial fibrosis is a common pathway of all kinds of chronic kidney diseases progressing to the end-stage of renal (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) increases the risk of developing cognitive dysfunction and it has been identified as a modifiable risk factor for Alzheimer's disease (AD) [1]. Regenerating family member 1 alpha (Reg-1?) protein, originally identified as a 16 kDa (...)
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AbstractBACKGROUND AND AIMSTubulointerstitial inflammation (TI) and tubulointerstitial fibrosis (TIF) are the common pathological manifestations of all progressive chronic kidney diseases (CKD). Exosomes-mediated cellular communication between tubular epithelial cells (TECs) and macrophages (...)
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AbstractBACKGROUND AND AIMSRenal insufficiency is associated with an increased risk of cardiovascular morbidity and mortality. Although cardiac troponin remains essential marker for the diagnosis of myocardial injury in the general population, the diagnostic utility remains uncertain in (...)
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AbstractBACKGROUND AND AIMSWhereas metabolic dysfunction-associated fatty liver disease (MAFLD) reflects multisystem disorders [1], many aspects of the association between MAFLD and extra-hepatic diseases are the issues to study. Glomerular hyperfiltration (GHF) is an early manifestation of (...)
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AbstractBACKGROUND AND AIMSIn chronic kidney disease (CKD) patients, the risk of kidney replacement therapy (KRT) is highly variable. In 2011, Tangri et al. developed the kidney failure risk equations (KFRE) to predict the 2- and 5-year probability of requiring kidney replacement therapy (KRT). (...)
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AbstractBACKGROUND AND AIMSThe incidence of chronic kidney disease (CKD) and its progression to end-stage renal disease (ESRD) differ between genders, so it can be surmised that the incidence of ESRD is different between males and females. Acceptance of dialysis therapy may not necessarily be (...)
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AbstractBACKGROUND AND AIMSThe incidence of chronic kidney disease (CKD) in patients with lung transplantation (LTx) has increased over the last decades.Progression factors recognized in the development of CKD are: older age and comorbidity of recipients, immunosuppressive (IS) toxicity and (...)
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AbstractBACKGROUND AND AIMSWhile dialysis has been the prevailing treatment paradigm in advanced CKD patients progressing to ESRD, this treatment approach may lead to a decline in physical function, loss of independence, and greater healthcare utilization among certain subgroups. We sought to (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease is associated with higher mortality compared with the general population, but mortality differences between men and women with CKD are poorly understood. Although the prevalence of CKD is consistently higher in women than in men, emerging (...)
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AbstractBACKGROUND AND AIMSMultimorbidity is the presence of two or more chronic conditions. Patients with multimorbidity suffer from a high treatment burden as they have to cope with numerous medications and attend multiple specialists. Some chronic conditions co-exist in predictable ways, (...)
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AbstractBACKGROUND AND AIMSOver 10% of the adult population worldwide is affected by chronic kidney disease (CKD). CKD is associated with an increased risk of kidney failure (KF), cardiovascular events and mortality. CKD is defined and staged by estimated glomerular filtration rate (eGFR), the (...)
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AbstractBACKGROUND AND AIMSThe prevalence of chronic kidney disease (CKD) is increasing globally. Often, the condition develops silently over time, with no or only a few symptoms in earlier stages. Therefore, early recognition in primary care may have an important role in ensuring diagnosis and (...)
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AbstractBACKGROUND AND AIMSAKI is the most frequent complication after respiratory failure in COVID-19. AKI increases mortality risk, length of hospital stay and healthcare costs, with possible progression towards CKD. Study aims: (1) evaluation of AKI incidence in 1020 COVID-19 hospitalized (...)
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AbstractBACKGROUND AND AIMSThe identification of possible risk factors for the progression of autosomal dominant polycystic kidney disease (ADPKD) is an emerging field, especially after the introduction of tolvaptan as the first disease-specific treatment. The present study aims to explore the (...)
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AbstractBACKGROUND AND AIMSAutosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease. It is caused by mutations in the PKD1 gene, and to a lesser extent PKD2. In this context, accumulating evidence has suggested a potential role of reduced AMP-activated (...)
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AbstractBACKGROUND AND AIMSFabry disease (FD) is a rare lysosomal storage disease causing progressive kidney, nervous system and heart disorders. Specific therapy may stop or mitigate disease progression, but is very expensive and results depend significantly on early initiation of treatment. (...)
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AbstractBACKGROUND AND AIMSCongenital anomalies of the kidney and urinary tract (CAKUT) represent the most common cause of chronic kidney failure in children. Despite growing knowledge of the genetic causes of CAKUT, the majority of cases remain etiologically unsolved. Genetic alterations in (...)
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AbstractBACKGROUND AND AIMSUMOD is a major risk gene for monogenic and complex forms of kidney disease. The encoded kidney-specific protein uromodulin is the most abundant protein in urine and related to chronic kidney disease, hypertension and pathogen defense. Through basolateral release from (...)
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AbstractBACKGROUND AND AIMSObesity, hyperglycemia and hypertension are critical risk factors for the onset and progression of diabetic kidney disease (DKD). Emerging evidence suggests that sodium-glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor (GLP-1R) agonists (...)
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AbstractBACKGROUND AND AIMSDeleterious consequences of type 1 interferons (T1-INFs) in the renal tissue have been envisioned in the context of viral and autoimmune diseases and in clinical therapies dealing with their administration.(1–3) Moreover, a participation of the T1-INF pathway has been (...)
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AbstractBACKGROUND AND AIMSRecent advances in the treatment of autosomal dominant polycystic kidney disease (ADPKD) highlight the interplay between the clinical and laboratory profile of the disease. This study aims to present the baseline characteristics of patients followed in a large ADPKD (...)
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AbstractBACKGROUND AND AIMSIn some patients with autosomal dominant polycystic kidney disease (ADPKD), one or both native kidneys are removed in the work-up for kidney transplantation. There is no consensus if and when a nephrectomy should be performed. Some centers advocate to routinely (...)
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AbstractBACKGROUND AND AIMSRare genetic diseases affecting claudins (CLDN), integral proteins located at intercellular tight junction that determine the ionic selectivity and permeability of the paracellular pathway, highlighted the importance of paracellular transport in body homeostasis. (...)
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AbstractBACKGROUND AND AIMSComplement dependent hemolytic and uremic syndrome (c-HUS) predisposes to hypertensive crisis and chronic hypertension. Reciprocally, hypertensive crisis may precipitate thrombotic microangiopathy (TMA) via endothelial shear stress. Patients of African ancestry have (...)
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AbstractBACKGROUND AND AIMSMutations of NPHS2 cause autosomal recessive steroid-resistant nephrotic syndrome (SRNS). The encoded podocin, a key component of the slit diaphragm, homo-oligomerizes through two C-terminal oligomerization sites. We formerly found that specific podocin variants may (...)
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AbstractBACKGROUND AND AIMSObesity, a widespread condition with an ever-increasing prevalence, imposes a great medical concern since it serves as a risk factor for a wide range of conditions, including the development of chronic kidney disease (CKD). Lipid accumulation and impaired fatty acid (...)
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AbstractBACKGROUND AND AIMSKidney plays a pivotal role on the maintenance of blood pressure by the regulation of sodium reabsorption. Aldosterone sensitive distal nephron finely tunes salt reabsorption through several transporters, including the epithelial sodium channel (ENaC). Alteration in (...)
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AbstractBACKGROUND AND AIMSANCA-associated vasculitis (AAV) is an autoimmune disease that causes end-stage renal disease in ?20%–25% of patients who develop kidney failure with progression to end-stage kidney disease with requirement of renal replacement therapy. Previous studies have found a (...)
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AbstractBACKGROUND AND AIMSA major barrier to the routine adoption of total kidney volume (TKV) as a clinical biomarker of disease for autosomal dominant polycystic disease (ADPKD) is the significant human operator time required even by experienced analysts (typically, 45–90 min per patient). (...)
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AbstractBACKGROUND AND AIMSIn autosomal dominant polycystic kidney disease (ADPKD), the enlarged kidneys can cause clinical problems, for instance pain or gastro-intestinal complaints, recurrent infections, or cause a lack of space for a kidney transplant. In selected ADPKD patients, a (...)
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AbstractBACKGROUND AND AIMSFabry disease (FD) is an X-linked rare disease characterized by deficient expression and activity of alpha-galactosidase A and consequent lysosomal accumulation of Gb3 and derivatives in various organs. Notwithstanding the first-line treatment with enzyme replacement (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) can be caused by a wide variety of systemic and renal disorders. In approximately 20% of patients, the cause of CKD remains unknown. Previous studies have shown that massively parallel sequencing (MPS) can be a valuable diagnostic tool in (...)
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AbstractBACKGROUND AND AIMSThere are approximately 300 inherited, congenital or acquired rare kidney diseases known. However, there is a significant delay in their diagnosis, which may result in inappropriate and potentially harmful testing or treatment due to misdiagnosis, or other adverse (...)
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AbstractBACKGROUND AND AIMSKidney organoids are a valuable and innovative model to understand genetic diseases, kidney development and transcriptomic dynamics. However, their proteome has not been analyzed so far. It is unclear how their proteome changes during differentiation, and if more (...)
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AbstractBACKGROUND AND AIMSAutosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cause of end-stage kidney disease. Currently, tolvaptan is the only treatment that has proven to delay disease progression. The most notable side-effect of this therapy is drug-induced (...)
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AbstractBACKGROUND AND AIMSOver the last years, there has been increasing evidence that defects in the energy metabolism of polycystic kidney disease (PKD) cyst lining cells, especially increased glucose dependency and defects in fatty acid oxidation, may underlie the pathogenesis of ADPKD, (...)
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AbstractBACKGROUNDMassively parallel sequencing (MPS) has propelled precision medicine into the next generation. With genetic data more accessible than ever, the focus has now shifted from obtaining data to converting the acquired data into applicable clinical information. A major obstacle to (...)
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AbstractBACKGROUND AND AIMSIrisin is a circulating myokine released by skeletal muscle after exercise. Its production decreases in chronic kidney disease (CKD) as a potential consequence of sarcopenia and physical inactivity. Irisin produces beneficial effects in glucose and lipid homeostasis: (...)
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AbstractBACKGROUND AND AIMSLoin pain-hematuria syndrome (LPHS) first described in 1967 is a complex and poorly understood rare disease, with a prevalence of 0.012%. It predominantly affects young women in their late 20s and early 30s2. Patients with LPHS experience extreme flank (loin) pain (...)
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AbstractBACKGROUND AND AIMSAnti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a debilitating disease that can have a significant impact on a patient's quality of life. The aim of this study was to assess the longitudinal quality of life amongst those diagnosed with AAV using (...)
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AbstractBACKGROUND AND AIMSThe etiopathogenesis underlying myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (MPO-ANCA-GN) remains incompletely understood. Furthermore, there are only limited treatment options and treatment resistance of MPO-ANCA-GN is still a (...)
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AbstractBACKGROUND AND AIMSThe overwhelming majority of individuals of West African ancestry carry an ‘erythroid silent’ FyB(ES) SNP in the promoter region of ACKR1 that causes a selective loss of ACKR1 in erythroid cells but does not affect its expression in endothelial cells. The FyB(ES) (...)
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AbstractBACKGROUND AND AIMSOxidative stress induced by non-hemodynamic effects of angiotensin II in podocytes participates in the development of glomerular injury and proteinuria. We studied the pathophysiologic roles of oxidative stress in angiotensin II-induced podocyte apoptosis.METHODMouse (...)
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AbstractBACKGROUND AND AIMSLiver cysts are the most common extra-renal manifestation in autosomal dominant polycystic kidney disease (ADPKD) and polycystic liver disease (PLD) may result in significant morbidity in a proportion of patients. The major objective of this study was to investigate (...)
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AbstractBACKGROUND AND AIMSAutosomal dominant polycystic kidney disease (ADPKD) is a hereditary disease characterized by the formation and growth of renal cysts, affecting the decrease of renal function, which may lead to end-stage renal disease (ESRD). Due to the enormous intrafamilial (...)
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AbstractBACKGROUND AND AIMSBBP-711 is an investigational small molecule inhibitor of glycolate oxidase (GO), currently in development for the treatment of primary hyperoxaluria type 1 (PH1) and recurrent nephrolithiasis. Selection of BBP-711 as a drug candidate followed structural activity (...)
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AbstractBACKGROUND AND AIMSACE2, part of the counter-regulatory arm of the renin–angiotensin system, serves both as protective toward oxidative stress and cardiovascular remodeling and as a key entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 has two isoforms, (...)
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AbstractBACKGROUND AND AIMSRecently, prognostic importance of antibodies in primary membranous nephropathy is well defined. However, knowledge about antibodies related to disease activity in membranous lupus nephritis (MLN) is limited. Exostosin1 and exostosin2 (EXT1/2) are novel antibodies (...)
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AbstractBACKGROUND AND AIMSAcute interstitial nephritis (AIN) represents an important cause of acute kidney injury. The most common etiology of AIN is drug-induced disease. Definitive diagnosis of AIN requires renal biopsy. Despite this, there is a lack of consensus regarding precise (...)
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AbstractBACKGROUND AND AIMSNeural cell adhesion molecule-1 (NCAM-1) has been found to be associated with central nervous system (CNS) injury in patients with lupus nephritis in small case series. This study aimed to explore the relationship between glomerular NCAM-1 expression and CNS injury in (...)
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AbstractBACKGROUND AND AIMSFocal segmental glomerulosclerosis (FSGS) describes a primary disease of podocytes (podocytopathy) and a secondary consequence of severe or progressive glomerular damage. No specific treatment options exist for FSGS, with many patients progressing to end-stage kidney (...)
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AbstractBACKGROUND AND AIMSWe recently developed a construct of an elastin-like polypeptide fused to VEGF (ELP-VEGF) and showed its efficacy to target and protect the kidney after single systemic administration in a swine model of unilateral renovascular disease (RVD) via therapeutic (...)
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AbstractBACKGROUND AND AIMSMaternal chronic kidney disease (CKD) is linked to offspring hypertension. Gut microbiome and its tryptophan metabolites, nitric oxide (NO) and renin–angiotensin system (RAS) are closely related to the development of hypertension. Hydrogen sulphide (H2S) has shown (...)
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AbstractBACKGROUND AND AIMSHuman immunodeficiency virus (HIV) continues to be a major global public health issue, having claimed millions of lives so far. Tenofovir disoproxil fumarate (TDF), a widely prescribed component in antiretroviral regimens for HIV treatment, has been associated with (...)
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AbstractBACKGROUND AND AIMSCalcium load is usually used in clinical practice to diagnose a normocalcaemic hyperparathyroidia in stone disease. However, the calcium load developed by Pak and colleagues has been described in very few patients. We aimed to provide data about calcium load in a (...)
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AbstractBACKGROUND AND AIMSMembranous nephropathy (MN) commonly presents with nephrotic syndrome and carries significant risk of progression to end-stage kidney disease (ESKD) (33% without treatment, 10%–20% with). Patients may spontaneously remit (up to 40%), but are also at risk of relapse. A (...)
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AbstractBACKGROUND AND AIMSClinical, in vitro, and animal model-derived evidence has demonstrated a critical involvement of the alternative complement pathway (aCP) in the pathogenesis of ANCA-associated vasculitis (AAV). In this regard, neutrophil extracellular traps (NETs) have been suggested (...)
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AbstractBACKGROUND AND AIMSThe pathogenesis underlying hepatitis B virus (HBV)-associated membranous nephropathy (MN) remains incompletely understood.METHODTo decipher the etiopathogenesis of HBV-associated MN, intrarenal single-cell RNA sequencing (scRNA-seq) was applied to the kidney biopsy (...)
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AbstractBACKGROUND AND AIMSAn abundance of inflammatory cells has been found in duodena of IgA nephropathy (IgAN) patients [1, 2]. The degree of intestinal inflammation was shown to correlate with the amount of proteinuria and haematuria in IgAN [3]. Serum intestinal fatty-acid-binding protein (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is characterized by cell death and inflammation. CD24 is a sialoglycoprotein which is induced during tissue damage and is not expressed in matured renal tissue. We explored the role of CD24 in the pathogenesis of folic acid-induced AKI (...)
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AbstractBACKGROUND AND AIMSUremic toxins (UT) are extremely relevant for the understanding of pathologies of the cardiovascular system once kidney and heart have a close relationship and share different functions. UT are divided into three groups according to physicochemical characteristics: (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) accounts for 13.3 million cases per year worldwide and further responsible for 1.7 million deaths per year [1]. Increasing incidence of AKI, progression toward CKD or end-stage renal disease (ESRD), affect on long term health, high mortality, (...)
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AbstractBACKGROUND AND AIMSPolycystic ovary syndrome (PCOS) is closely related to the onset and development of metabolic abnormalities. However, the correlation between PCOS and kidney injury has not been clarified, and the underlying mechanism remains unknown. Vitamin D therapy has beneficial (...)
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AbstractBACKGROUND AND AIMSA small percentage of patients with autosomal dominant polycystic kidney disease (ADPKD) have no clear family history. The clinical course and prognosis of the disease in this subgroup of patients may be different. The present study investigates the progression and (...)
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AbstractBACKGROUND AND AIMSAbundant water intake is advised for patients with autosomal dominant polycystic kidney disease (ADPKD) Meijer and Casteleijn (Riding the waves: evidence for a beneficial effect of increased water intake in autosomal dominant polycystic kidney disease patients? (...)
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AbstractBACKGROUND AND AIMSThe association between Alport syndrome (AS) and IgA-nephropathy (IgAN) recently shown suggests that the abnormal glomerular basement membrane (GBM) resulting from the pathogenic COL4A3/A4/A5 variants may predispose to immune-mediated injury. The aim of study was to (...)
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AbstractBACKGROUND AND AIMSCystinuria is a rare genetic disease characterized by impaired tubular transport of cystine and other dibasic amino acids that leads to cystine renal calculi. Although being a rare condition, cystinuria is the most frequent monogenic cause of nephrolithiasis (...)
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AbstractBACKGROUND AND AIMSEnd-stage renal disease (ESRD) is essentially a chronic inflammatory state and, consequently, it engenders detrimental effects on the immune system. Due to the specific uremic environment, multiple phenotypic lymphocyte alterations are described, similar but not (...)
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AbstractBACKGROUND AND AIMSAutosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease with diffuse cysts in both kidneys and is responsible for 5–10% of end-stage renal disease Levy and Feingold (Estimating prevalence in single-gene kidney diseases (...)
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AbstractBACKGROUND AND AIMSAutosomal dominant polycystic kidney disease (ADPKD) is the most common inherited renal disease characterized by the formation of cysts that destroy normal renal parenchyma. Tolvaptan (vasopressin antagonist) is the only drug approved today to slow disease (...)
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AbstractBACKGROUND AND AIMSADTKD represents a recently described group of kidney diseases, characterized by chronic interstitial nephritis (CIN), in most cases hereditary, with an autosomal dominant inheritance pattern, subclassified according to its genetic cause, when identified. Mutations in (...)
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AbstractBACKGROUND AND AIMSTotal kidney volume (TKV) in patients with autosomal dominant polycystic kidney disease (ADPKD) is a known progression factor in these patients. Low levels of klotho and high levels of FGF23 in the blood of patients with ADPKD have been correlated with higher TKV even (...)
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AbstractBACKGROUND AND AIMSUrinary albumin excretion (UAE) is considered as a risk marker for chronic kidney disease (CKD), but the exact pathophysiological mechanisms are not known. Studies have shown that urinary orosomucoid excretion (UOE) is associated with general endothelial dysfunction (...)
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AbstractBACKGROUND AND AIMSGlomerular filtration rate (GFR) is the most common measure of kidney function. Measuring GFR is often infeasible in routine clinical practice and population studies, where it is estimated instead from blood biomarkers. Three currently recommended equations, (...)
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AbstractBACKGROUND AND AIMSNovel oral anticoagulants (NOAC) are currently the first-line choice for stroke prevention in patients with atrial fibrillation (AF), as they have a better risk/benefit profile compared with vitamin K antagonists (VKA). Secondary analyses of trials suggest that NOAC (...)
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AbstractBACKGROUND AND AIMSNitric oxide (NO) deficiency is associated with endothelial dysfunction, hypertension, vasoconstriction, atherosclerosis and chronic kidney disease (CKD) [1]. Reduced NO bioavailability is hypothesized to play a vital role in kidney function impairment and CKD. The (...)
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AbstractBACKGROUND AND AIMSRenal fibrosis, a progressive process of extracellular matrix accumulation leading to renal failure, lacks effective treatment. Expression of the AXL receptor tyrosine kinase has been implicated in kidney injury and mesangial proliferation [1]. Inhibition of AXL (...)
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AbstractBACKGROUND AND AIMSAround the globe, over 850 million patients suffer from chronic kidney disease (CKD). These have associated with high mortality rates, in particular when undergoing renal replacement therapies (RRT) such as dialysis, reaching up to 10% a year, and therefore, are (...)
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AbstractBACKGROUND AND AIMSAmong patients with ST-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI), short- and long-term renal function evaluations are of prime importance. Most studies have focused on short-term renal dysfunction and acute kidney (...)
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AbstractBACKGROUND AND AIMSPaediatric patients with chronic kidney disease (CKD) develop significant atherosclerosis and vascular calcifications until early adulthood. Largely devoid of confounding lifestyle related factors and underlying disease mostly limited to congenital abnormalities of (...)
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AbstractBACKGROUND AND AIMSAtrial fibrillation remains the most common sustained arrhythmia in the general population, with prevalence inversely correlated with renal function. Management of atrial fibrillation relies on either rhythm control or rate control, however, the choice of treatment in (...)
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AbstractBACKGROUND AND AIMSThe aetiology of idiopathic nephrotic syndrome (INS) remains partially unknown. Viral infections have been reported to be associated with INS onset and relapse. The COVID-19 pandemic led to several national lockdowns aimed at limiting virus transmission. In France, (...)
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AbstractBACKGROUND AND AIMSPatients with chronic kidney disease (CKD) have a higher risk to develop heart failure with preserved ejection fraction (HFpEF). We showed in a swine model of CKD with diastolic dysfunction and cardiac remodelling that these cardiac features are associated with (...)
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AbstractBACKGROUND AND AIMSSickle cell disease (SCD) induces a decline in urine concentration and progressive deterioration of kidney (K) function. Hyperfiltration is often observed before this decline, and plasma urea is low. Oral urea or hydroxyurea improves the condition of these patients (...)
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AbstractBACKGROUND AND AIMSAdrenal glands participate in cardiovascular physiology and pathophysiology via the synthesis and secretion of various well-known compounds like mineralocorticoids, amine peptides and glucocorticoids. In this study, a previously unknown systemic function of adrenal (...)
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AbstractBACKGROUND AND AIMSBeta-hydroxybutyrate (BHB), a ketone body, has shown to be renoprotective in various disease-specific preclinical studies. The underlying mechanism of this renoprotective effect might be via the reduction of inflammation, apoptosis, oxidative stress, and fibrosis. (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is an independent risk factor for heart failure with preserved ejection fraction (HFpEF), a progressive condition that affects ?50% of patients in dialysis. We developed a swine model of CKD-HFpEF and showed that renal inflammatory (...)
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AbstractBACKGROUND AND AIMSGlucagon-like peptide-1 receptor agonists, such as semaglutide, have been associated with reductions in albuminuria, and may preserve estimated glomerular filtration rate (eGFR) in people with type 2 diabetes (T2D). However, it has not been explored whether treatment (...)
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AbstractBACKGROUND AND AIMSThe optimal ambulatory management of hyperkalaemia (HK) in patients with chronic kidney disease (CKD) is still an important unmet challenge. Common strategies include dose reduction or discontinuation of nephroprotective medications (e.g. renin-angiotensin-aldosterone (...)
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AbstractBACKGROUND AND AIMSp-cresyl sulfate (PCS) is associated with inflammation and its contribution to cardiovascular damage in patients with chronic kidney disease (CKD). The brachial-ankle pulse wave velocity (baPWV) is a simple marker to assess the peripheral artery stiffness (PAS) and is (...)
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AbstractBACKGROUND AND AIMSSeveral studies have reported that depression has a high prevalence in patients with diabetes or chronic kidney disease. However, the relationship between weight changes and the risk of depression has not been elucidated in patients with diabetic kidney disease (...)
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AbstractBACKGROUND AND AIMSOver 7 million patients suffer from end-stage kidney disease (ESKD) worldwide [1]. Due to low kidney function, patients often become hyperphosphatemic, which leads to an increased risk of death [2]. Patients usually rely on dietary restrictions and phosphate (P) (...)
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AbstractBACKGROUND AND AIMSHIV patients have an increased risk of chronic kidney disease (CKD) development. Endothelial dysfunction was previously associated with kidney dysfunction markers. This study aims to investigate the association between renal markers and renal dysfunction biomarkers (...)
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AbstractBACKGROUND AND AIMSThe mass vaccination for COVID-19 has raised new concerns for patients with immune-mediated nephropathies: there is a small but growing literature of case-reports linking SARS-CoV-2 vaccines with heightened off-target immune responses leading to de novo or relapsing (...)
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AbstractBACKGROUND AND AIMSEvidence shows galactose-deficient IgG4 is able to act complement system via lectin pathway in phospholipase A2 receptor (PLA2R) related idiopathic membranous nephropathy (IMN). However, the severity of PLA2R-related IMN runs parallel with neither the electron (...)
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AbstractBACKGROUND AND AIMSAnti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a necrotizing vasculitis characterized by inflammation of small blood vessels, being the kidney one of the most frequently affected organs. AAV has a high morbidity and mortality, developing (...)
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AbstractBACKGROUND AND AIMSTreatment-resistant primary focal segmental glomerulosclerosis (FSGS) is a rare glomerulopathy associated with nephrotic range proteinuria (>3.5 g/24 h). Treatment goals are reduction in proteinuria, which can delay progression to end-stage renal disease. Lack of (...)
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AbstractBACKGROUND AND AIMSIn the COVID 19 pandemic era, anti SARS-CoV-2 vaccination showed high efficacy at preventing the infection and its most severe complications. The aim of this report is to describe an unusual double glomerulopathy related to anti SARS-CoV-2 vaccination and the good (...)
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AbstractBACKGROUND AND AIMSAlternative complement pathway (AP) dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and non-dominant (...)
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AbstractBACKGROUND AND AIMSSystemic AL amyloidosis is a rare pathology associated with the precipitation of monoclonal immunoglobulin light chains in the form of fibrils in various organs. Clinical presentations are extremely variable and diagnosis is often delayed. The two most affected organs (...)
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AbstractBACKGROUND AND AIMSImmunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, with an estimated annual incidence of 25 per million. Patients with persistent proteinuria ? 1 g/day are at increased risk of disease progression, with 30% or more (...)
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AbstractBACKGROUND AND AIMSDespite several clinical trials, treatment with corticosteroids in patients with Immunoglobulin A nephropathy (IgAN) remains controversial [1, 2]. The recently updated KDIGO guidelines suggests that treatment with corticosteroids could be considered in patients with (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) is the most serious health problem and constitutes the 16th leading cause of death worldwide. Multiple studies have identified acute kidney injury (AKI) as a risk factor for the development and progression of CKD [1]. Despite extensive (...)
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AbstractBACKGROUND AND AIMSThe dysregulation of the angiopoietin–Tie system is associated with the development of sepsis-associated endothelial dysfunction. Bacterial quorum-sensing molecules act as pathogen-associated molecular patterns; however, the effect of quorum-sensing molecules on the (...)
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AbstractBACKGROUND AND AIMSObstructive nephropathy decreases renal blood flow (RBF) and glomerular filtration rate (GFR). Glycogen synthase kinase 3? (GSK3 ?), an apoptotic enzyme, is increased in a model of unilateral obstruction. Treatment with a single dose of lithium, a selective inhibitor of (...)
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AbstractBACKGROUND AND AIMSNephropathology is essential for the diagnosis of kidney diseases. Deep learning-based image analyses, including segmentation of kidney histology, open new possibilities for reproducible quantitative precision pathology. Current segmentation approaches in kidney (...)
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AbstractBACKGROUND AND AIMSImmunosuppressed patients are in general less likely to achieve a detectable antibody response to SARS-CoV-2 after the primary doses of vaccine administration. However, there are limited data for the effect of a third booster dose in this patient population, (...)
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AbstractBACKGROUND AND AIMSTo explore the frequency and impact of an autoimmune disease past-medical history (PMH) in the clinical picture and outcomes of patients with ANCA-associated vasculitis (AAV).METHODThis is a retrospective study of patients with biopsy-proven AAV, >16 years old, with (...)
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AbstractBACKGROUND AND AIMSImmunoglobulin A nephropathy (IgAN) is the leading cause of primary glomerulonephritis worldwide with limited treatment options, especially for high-risk patients [1]. BION-1301 is a novel humanized monoclonal antibody that blocks a proliferation-inducing ligand (...)
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AbstractBACKGROUND AND AIMSCurrent treatment strategies of IgA nephropathy (IgAN) primarily involve blood pressure control, renin–angiotensin–aldosterone system inhibitors (RAASIs), and glucocorticosteroids (GCs), which are recommended when the supporting therapies fail to reduce proteinuria (PU) (...)
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AbstractBACKGROUND AND AIMSAfter the start of the vaccination campaign against the SARS-COV-2 pandemic, it is possible that the number of cases of de novo and relapsing glomerulopathies will increase.So far, most of the publications related to post-vaccination minimal change disease (also (...)
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AbstractBACKGROUND AND AIMSIgA nephropathy is a progressive renal disease with up to 30% of patients reaching end stage kidney disease within 10–20 years. The aim of this study was to analyze the phenotype of patients with IgA nephropathy followed in a tertiary renal center and explore its (...)
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AbstractBACKGROUND AND AIMSPlasma cells (PC) are the most differentiated antibody and cytokine-producing B lineage cells and are thought to contribute to the perpetuation of inflammation in patients with ANCA-associated vasculitis (AAV). Agents targeting PCs are of interest in AAV, however, (...)
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AbstractBACKGROUND AND AIMSFibrillary glomerulopathy (FGN) is a rare glomerular deposit disease accounting for less than 1% of annual native kidney biopsies. Its pathogenesis is still not fully understood. Immunofluorescence (IF) techniques in the vast majority of cases reveal the presence of (...)
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AbstractBACKGROUNDAnti-neutrophil cytoplasm antibodies (ANCA) associated vasculitis (AAV) is a rare and complex autoimmune disease. Induction remission and maintenance treatment typically includes glucocorticoids (GC) in addition to other immunosuppressive medications. Recent trials such as (...)
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AbstractBACKGROUND AND AIMSGreat progresses have been made in the diagnosis and treatment of membranous nephropathy (MN), but some patients still do not respond to the treatment. We performed single-cell sequencing to analyze the urine cells of patients with and without complete remission of (...)
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AbstractBACKGROUNDS AND AIMSOver the past two decades, considerable progress has been made in maintaining remission in patients with anti-neutrophil cytoplasmic antibody (ANCA) vasculitis using a variety of medications, including rituximab, azathioprine, mycophenolate, methotrexate, and (...)
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AbstractBACKGROUND AND AIMSThe development and massive use of mRNA COVID-19 vaccine BNT162b2 has raised new concerns on triggering de novo immune-mediated diseases, in particular rare diseases as glomerulonephritis (GN), even if the security profile is excellent and severe reactions have been (...)
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AbstractBACKGROUND AND AIMSImmunoglobulin A nephropathy (IgAN) is the most common glomerular disease worldwide. Despite optimized standard of care treatment, up to 40% of individuals with IgAN develop kidney failure requiring dialysis or kidney transplantation, consequently seriously affecting (...)
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AbstractBACKGROUND AND AIMSThe type of donor has an important impact on the renal prognosis of the recipient. Thus, it has been observed that the decline of renal function is higher in deceased donor (DD) than those observed in living donors (LD). These could be related with the (...)
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AbstractBACKGROUND AND AIMSIdiopathic membranous nephropathy (IMN) is one of the main causes of nephrotic syndrome in the adult population. Approximately between 20% and 40% of patients who suffer from it require replacement therapy in a period of 10–15 years. Recently, it has been reported that (...)
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AbstractBACKGROUNDThe biological process of renal aging is characterized by progressive structural and functional deterioration of the kidney leading to end-stage renal disease in elderly patients. Renal aging includes a complex network of cellular signaling stress such as senescence, (...)
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AbstractBACKGROUND AND AIMSDiabetic kidney disease (DKD) affects more than 30% of all diabetic patients. It is strongly associated with increased morbidity, mortality and global healthcare burden. Furthermore, it is considered the primary cause of end-stage kidney disease (ESKD). The renal (...)
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AbstractBACKGROUND AND AIMSImmunoglobulin A nephropathy (IgAN) is the leading cause of primary glomerulonephritis worldwide with limited treatment options, especially for high-risk patients [1]. BION-1301 is a novel humanized monoclonal antibody that blocks a proliferation-inducing ligand (...)
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AbstractBACKGROUND AND AIMSThe current strategy to fight against the COVID-19 pandemic involves active patient vaccination. Patients with renal and autoimmune diseases are in high risk for severe COVID-19 infection [1]. Therefore they should be prioritized for vaccination. Immunoglobulin A (...)
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AbstractBACKGROUND AND AIMSRecently, evidence has emerged that the ubiquitin system, which is involved in extracellular protein degradation, is most susceptible to damage in podocytes in cases of severe nephritis. We studied anti-ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) antibodies in (...)
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AbstractBACKGROUND AND AIMSTransforming growth factor-?1 (TGF-?1) has long been considered as a potent, multifunctional cytokine that is involved in the pathogenesis of fibrosis and inflammation, which acts through Smad signaling in renal pathology. We intended to investigate the expression of (...)
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AbstractBACKGROUND AND AIMSIt is known that IgA-nephropathy (IgAN) can be secondary to liver disease, skin disease, lung disease, etc. There is also evidence of an association between IgAN and celiac disease. In the Russian population, there are no studies aimed at identifying the prevalence of (...)
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AbstractBACKGROUND AND AIMSRituximab (RTX) showed some efficacy in treatment of minimal change disease (MCD) and primary focal segmental glomerulosclerosis (pFSGS) [1]. The results of its off-label use and as steroid-sparing agent were especially promising in steroid-dependent, frequently (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is histologically characterized by tubular cell death and inflammation. It has demonstrated that cell death in renal tubule cells on AKI could be introduced by regulated necrosis or apoptosis, but the molecular mechanisms are reported to be (...)
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AbstractBACKGROUND AND AIMSFosl1 (FRA1, Fos-related-antigen 1) is a transcription factor of the AP-1 complex (activator protein 1) that regulates the expression of genes that regulates processes involved in acute kidney injury (AKI) such differentiation, inflammation, proliferation and cell (...)
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AbstractBACKGROUND AND AIMSCisplatin nephrotoxicity is an important cause of acute kidney injury (AKI), limiting cisplatin application in cancer therapy. Growing evidence had suggested that genome instability, telomere dysfunction and DNA damage were involved in the tubular epithelial cells (...)
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AbstractBACKGROUND AND AIMSReplication of the enveloped SARS-COV2 virus can alter lipidomic composition and metabolism of infected cells [1]. These alterations commonly result in a decline in HDL, total cholesterol and LDL, and an increase in triglyceride levels in COVID-19 patients. (...)
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AbstractBACKGROUND AND AIMSAlport Syndrome (AS; ORPHA 63) is one of the most frequent hereditary kidney diseases (HKD), caused by COL4A5 mutations in X-linked AS (XLAS) and COL4A3-4 mutations in the autosomal forms, dominant (ADAS) and recessive (ARAS). Definitive diagnosis of AS is essential (...)
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AbstractBACKGROUND AND AIMSThe most common cause of the end-stage renal disease is diabetes and hypertension. However, most centers do not try to find the cause of hypertension in patients with early-stage CKD but give antihypertensive medicine because most centers regard the cause as essential (...)
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AbstractBACKGROUND AND AIMSAlthough C1q nephropathy (C1QN) was introduced three decades ago, the clinical significance and renal outcomes of C1QN remain unclear. Furthermore, it is uncertain whether the diagnosis of C1QN could be a new pathologic entity with clinical meanings. This study aimed (...)
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AbstractBACKGROUND AND AIMSCases of collapsing glomerulopathy in association with COVID-19 infection have been reported worldwide, frequently referred to as COVAN (COVID-19 Associated Nephropathy). Affected patients are almost exclusively of Black ethnicity, likely associated with APOL-1 renal (...)
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AbstractBACKGROUND AND AIMSGlucocorticoids are used as primary treatment in IgA nephropathy (IgAN), and they manifest their effects by binding to intracellular glucocorticoid receptors. Studies have shown that GCR expression correlates with the degree of steroid response in various diseases. (...)
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AbstractBACKGROUND AND AIMSAcute Kidney Injury (AKI) is characterized by a rapid deterioration of kidney function. Recently, we showed that tubular epithelial cells (TC) respond to AKI by triggering polyploidy, a condition in which a normally diploid cell acquires additional sets of (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is a major cardiovascular risk factor, regardless of the severity or the origin of the AKI. Among this risk, AKI imparts an array of signals and long-term physiologic alterations that can precipitate heart insufficiency and hypertrophy. (...)
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AbstractBACKGROUND AND AIMSAlterations in protein homeostasis in tubular cells lead to endoplasmic reticulum (ER) stress activating the unfolded protein response (UPR) pathway, which contributes to repair or aggravate the renal damage [1]. This pathway is initiated by three major protein (...)
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AbstractBACKGROUND AND AIMSThe complement system plays a key role in the pathophysiology of renal thrombotic microangiopathies (TMA), as illustrated by atypical hemolytic uremic syndrome (HUS) characterized by a high rate of mutations in complement proteins. However, complement abnormalities (...)
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AbstractBACKGROUND AND AIMSRenal fibrosis is a main feature of chronic kidney disease (CKD) that participates in its progression to the end stage.(1) N-acetylglucosaminyltransferase 5 (MGAT5) adds N-acetylglucosamines to newly synthesized glycoproteins and is overexpressed in tumors (...)
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AbstractBACKGROUND AND AIMSIgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and an important cause of kidney failure requiring kidney replacement therapy [1]. Given that IgAN has no specific treatment and the options available are often associated with (...)
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AbstractBACKGROUND AND AIMSMinimal change lesion (MCD) accounts for 10–15% of adult patients with nephrotic syndrome and is characterized by edema, nephrotic-ranged proteinuria (NP) and pathologic findings of nearly normal appearance of glomeruli on light microscopy, minimal staining of (...)
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AbstractBACKGROUND AND AIMSPersistent proteinuria (urinary protein level [UPr]>1 g/24 h) and especially nephrotic range proteinuria, is a poor prognostic factor in IgA nephropathy. Patients with proteinuria > 3.5 g/24 h have a 24-fold faster decline of renal function as compared with those with (...)
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AbstractBACKGROUND AND AIMSThe attempt to identify the most suitable therapies and their appropriate dose is at the base of tailored medicine approach. We decided to analyze the renal outcomes of patients affected by primary membranous nephropathy (MN) referring to our unit from January 2005 to (...)
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AbstractBACKGROUND AND AIMSA Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents with severe pneumonia and fatal systemic complications. Currently, SARS-CoV-2 vaccines are effective in reducing the risk of onset and severity of (...)
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AbstractBACKGROUND AND AIMSFocal Segmental Glomerulosclerosis (FSGS) and Minimal Change Disease (MCD) are most common seen glomerulonephritis. Differential diagnosis between FSGS and MCD by light microscopy (LM) cannot be made in some times. In this situation, electron microscopy (EM) is needed (...)
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AbstractBACKGROUND AND AIMSMesangial cell (MC) activation, characterized by excess proliferation and extra-cellular matrix deposition is the initiating intra-renal event in the pathogenesis of mesangioproliferative glomerulonephritis (MPGN), including IgA nephropathy (IgAN). However, the (...)
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AbstractBACKGROUND AND AIMSAlport Syndrome (AS) is the second most common genetic kidney disease and results from mutations in COL4A3, A4 or A5 genes. It is characterized by glomerulonephritis, CKD, hearing loss, and ocular lens defects. Estimated incidence is ? 1 in 50 000 live births with (...)
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AbstractBACKGROUND AND AIMSIn nondiabetic population, primary membranous nephropathy (PMN) is the most common cause of idiopathic nephrotic syndrome in the world. Urokinase-type plasminogen activator (uPA) is one of the key members of fibrinolysis system, which functions as dissolving blood (...)
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AbstractBACKGROUND AND AIMSANCA-associated vasculitis (AAV) has been associated with increased risk of cardiovascular (CV) events. The purpose of the present study was to asses cardiovascular risk determinants and outcomes in a two-centre prospective cohort of AAV patients.METHODPrevalent (...)
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AbstractBACKGROUND AND AIMSLupus nephritis (LN) is one of the most common complications of SLE that can lead to worsened kidney function or renal failure. Antineutrophil cytoplasmic antibodies (ANCA) are autoantibodies that are against antigens in the cytoplasm of neutrophils and monocytes and (...)
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AbstractBACKGROUND AND AIMSThe new advances in cancer treatments and the increasing prevalence of kidney disease in the population with cancer have extended the indication of kidney biopsies. The purpose of the study is to analyze clinical and histological characteristics of patients with (...)
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AbstractBACKGROUND AND AIMSThe atypical hemolytic uremic syndrome (aHUS) is a complement-mediated (CM) ultrarare disease that manifests as thrombotic microangiopathy (TMA) with preferential small kidney vessels involvement. aHUS is caused by genetic or acquired deregulation of complement (C’) (...)
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AbstractBACKGROUND AND AIMSWith chronic kidney disease (CKD) prevalence rapidly increasing, the need for novel therapies is rising. Sodium glucose co-transporter-2 (SGLT2) inhibitors were originally developed to treat hyperglycemia in patients with type 2 diabetes mellitus. Clinical trials with (...)
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AbstractBACKGROUND AND AIMSMicroscopic hematuria, associated with variable proteinuria, is the most common clinical feature of IgA nephropathy (IgAN). However, its role in the disease progression is still controversial. This study aims to assess whether remission of hematuria is associated with (...)
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AbstractBACKGROUND AND AIMSAntineutrophil cytoplasmatic antibody (ANCA) associated vasculitis (AAV) is a small vessel vasculitis hallmarked by the presence of antibodies against antigens in cytoplasmic granules of neutrophils. Vaccines per se stimulate the immune system, including the innate (...)
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AbstractBACKGROUND AND AIMSThe kidney disease secondary to obesity is obesity-related glomerulopathy characterized by the following: glomerulomegalia, progressive glomerulosclerosis, proteinuria and progression of renal failure. The aims of the present study were to evaluate the clinical (...)
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AbstractBACKGROUND AND AIMSNodular glomerulosclerosis (NGS) is a histological diagnosis that can be found in several etiologies. It corresponds to a particular form of expansion of the extracellular matrix within the mesangium.Glomerulosclerosis is not very specific, its nodular form is on the (...)
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AbstractBACKGROUND AND AIMSMemo deletion in mice caused a bone disease with diminished osteoblast and osteoclast biomarkers in serum [1], resembling the alterations occurring in adynamic bone disease in humans with renal failure, as well as those found in Klotho-deficient mice [2]. In addition, (...)
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AbstractBACKGROUND AND AIMSFrailty is a pre-morbid condition characterized by physiological decline and reduced physiological reserve leading to increased vulnerability to disease, especially common among older adults. Tissue and organ function is underpinned by effective haemodynamic (...)
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AbstractBACKGROUND AND AIMSRenal ischemia/reperfusion injury (IRI)-induced acute kidney injury is associated with high mortality and morbidity and effective therapies are lacking. We previously showed that Sigma-1 receptor (S1R) agonist fluvoxamine treatment is protective against renal IRI (...)
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AbstractBACKGROUND AND AIMSCirculating histones play a crucial role in the development and progression of sepsis and is associated with high mortality. Hemadsorption with the CytoSorb® filter has been shown to non-specifically eliminate systemic circulating histones in plasma from injured (...)
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AbstractBACKGROUND AND AIMSTolvaptan, a vasopressin antagonist, is a drug that acts by slowing the progression of autosomal dominant polycystic kidney disease (ADPKD). Its administration is not free of side effects. To assess the long-term safety profile of ADPKD patients treated with (...)
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AbstractBACKGROUND AND AIMSUrinary sediment (U-Sed) is a noninvasive laboratory test that can be performed by an automated analyzer or manually by trained personnel. Manual U-Sed remains the diagnostic standard because it excels at distinguishing isomorphic from dysmorphic red blood cells, (...)
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AbstractBACKGROUND AND AIMSAutopsies are an invaluable tool in medicine for studying the pathophysiology of diseases, including kidney diseases and causes of death. To facilitate multicenter autopsy-based studies and to provide a single point of contact for data analysis and reporting, the (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) affects around 10% of adults worldwide and an estimated 13–17% in Germany1. Imaging is a novel, promising approach to identify additional markers of kidney function and CKD2. Within a large, population-based cohort study, the German (...)
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AbstractBACKGROUND AND AIMSThe approach to Alport syndrome is a difficult task due to the phenotypic variability of its symptomatology, incomplete penetrance and its different forms of inheritance [1].It presents a high degree of underdiagnosis, both because of erratic diagnosis as well as the (...)
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AbstractBACKGROUND AND AIMSHypercholesterolemia in nephrotic syndrome is commonly resistant to statin therapy and represents an important clinical challenge both for cardiovascular risk prevention and to eliminate lipotoxic effect on podocytes. Serum PCSK9 level is elevated in nephrotic (...)
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AbstractBACKGROUND AND AIMSVenous thrombosis (VT) is an established cause of increased morbidity and mortality amongst patients with nephrotic syndrome. Previous studies suggest primary membranous nephropathy (PMN) to be associated with the highest risk of developing VT amongst all nephrotic (...)
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AbstractBACKGROUND AND AIMSBelimumab (BEL), a recombinant human monoclonal antibody directed against B-cell activating factor (BAFF), is the first approved biological agent for patients with systemic lupus erythematosus (SLE) and a high level of disease activity or lupus nephritis (LN). BEL (...)
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AbstractBACKGROUND AND AIMSAutosomal dominant polycystic kidney disease (ADPKD) is prone to multiple complications, including cyst infection (CyI). 18F-FDG PET/CT imaging proved useful in the diagnosis of renal and hepatic CyI. A 4-point scale comparing the uptake of 18F-FDG in the suspected (...)
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AbstractBACKGROUND AND AIMSTolvaptan (TVP) blocks vasopressin V2 receptors causing severe polyuria. Few works have analyzed factors associated with urine output in autosomal dominant polycystic kidney disease (ADPKD) patients taking TVP.METHODWe selected 24 h urine samples from ADPKD patients (...)
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AbstractBACKGROUND AND AIMSAlport syndrome (AS) is a hereditary renal disease characterized by progressive loss of kidney function and often accompanied by sensorineural hearing loss and ocular abnormalities [1]. The variety of symptoms and their severity is closely associated with mode of (...)
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AbstractBACKGROUND AND AIMSAutosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. The only treatment approved today to slow its progression is tolvaptan (vasopressin antagonist). However, there is no clinical efficacy parameter for follow-up during (...)
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AbstractBACKGROUND AND AIMSEstablishing the genetic basis of renal disease is pivotal to improve diagnostic and treatment strategies. Pathogenic copy number variations (CNVs) caused by chromosomal imbalances contribute significantly to the pediatric renal disease burden, especially in children (...)
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AbstractBACKGROUND AND AIMSX-linked hypophosphoremic rickets (XLH) is a rare disease caused by mutations in the PHEX gene leading to an increase in the serum levels of FGF23, which inhibits the tubular reabsorption of phosphates and the production of 1,25(OH)2D. These alterations cause (...)
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AbstractBACKGROUND AND AIMSRoutine pathological diagnostics in kidneys are mainly based on semi-quantitative eyeballing. In own former studies, we showed predictive value of precise immune cell quantification in allografts using digital semi-automated techniques. We now aim to achieve fully (...)
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AbstractBACKGROUND AND AIMSThe glycocalyx is a carbohydrate-rich gel-like mesh, which covers the luminal surface of cells, including the endothelium. The glycocalyx is involved in many regulatory functions of the endothelium, including vascular permeability. In chronic kidney disease (CKD), (...)
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AbstractBACKGROUND AND AIMSAccumulation of extracellular matrix (ECM) proteins is a hallmark of renal fibrosis, leading to altered tissue homeostasis, kidney failure and ultimately death. Current treatment strategies are ineffective in halting renal fibrogenesis, and drug discovery is hampered (...)
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AbstractBACKGROUND AND AIMSMAGI2 is a tight junction protein and member of the membrane-associated guanylate kinase (MAGUK) family. In the glomerulus, it is exclusively expressed in podocytes and interacts with the slit diaphragm protein nephrin. Recent studies and podocyte-specific MAGI2 (...)
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AbstractBACKGROUND AND AIMSPatients with primary hyperoxaluria type I (PH I) are prone to develop early end-stage kidney failure (ESKF). Systemic deposition of calcium-oxalate (CaOx) crystals starts when renal function declines and plasma oxalate (Pox) increases >30 µmol/L. It is anticipated (...)
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AbstractBACKGROUND AND AIMSReduction and normalization of calciuria in children with idiopathic hypercalciuria (IH) was published by Aladjem et al. (1996). The association between IH and hypocitraturia was described in two Brazilian studies; however, further studies are needed to determinate (...)
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AbstractBACKGROUND AND AIMSPulmonary-renal syndrome (PRS) is characterized by rapidly progressive glomerulonephritis and lung vasculitis. Most common causes of PRS are Goodpasture's disease, antineutrophil cytoplasm antibody (ANCA) associated vasculitis and systemic lupus erythematosus; rarely (...)
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Abstract>BACKGROUND AND AIMSThe COVID-19 pandemic has brought to the forefront a wide spectrum of renal injuries that included glomerulopathies, some of which were recently highlighted in various case reports. These consist of focal and segmental glomerulosclerosis (FSGS) and minimal change (...)
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AbstractBACKGROUND AND AIMSThe progression of immunoglobulin A nephropathy (IgAN) is currently assessed using the Oxford MEST-C score, which uses five indicators (mesangial and endocapillary hypercellularity, segmental sclerosis, interstitial fibrosis/tubular atrophy and the presence of (...)
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AbstractBACKGROUND AND AIMSgddY mice are an IgA nephropathy (IgAN)-prone mouse model that develops albuminuria by 8 weeks (wks) of age with glomerular IgA, IgG and C3 deposits and progressive mesangioproliferative glomerulonephritis. We have previously shown that sparsentan (SP), a novel, (...)
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AbstractBACKGROUND AND AIMSThe mainstay of treatment for high-risk primary membranous nephropathy (MN) is the cyclic steroid-oral cyclophosphamide (CYC) regimen (modified Ponticelli regimen). However, there has been increasing awareness of serious treatment-related toxicity. Intravenous CYC (...)
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AbstractBACKGROUND AND AIMSLupus nephritis (LN) is the most serious organ manifestation of systemic lupus erythematosus (SLE), occurring in 40%–60% of subjects with SLE with worse outcomes. LN is mediated by antibody deposition in glomeruli, but the mechanisms leading to the immune deposits and (...)
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AbstractBACKGROUND AND AIMSRenal proximal tubule epithelial cells (RPTECs) are responsible for solute and protein reabsorption. It has been described that the human RPTEC/TERT1 cell line expresses several transporters, including the cubilin–amnionless–megalin complex that is responsible for the (...)
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AbstractBACKGROUND AND AIMSThere is podocyte involvement in corticosteroid-resistant nephrotic syndrome. A certain number of proteins play an essential role in the biology of the podocyte; the mutation of these proteins generates the aforementioned pathology. The aim of this work is the (...)
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AbstractBACKGROUND AND AIMSADTKD–UMOD (Autosomal dominant tubulointerstitial kidney disease–UMOD) is a rare genetic disease due to a heterozygous mutation in the UMOD gene encoding uromodulin. It is classically characterized by minimal proteinuria, slowly progressive CKD, hyperuricemia and (...)
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AbstractBACKGROUND AND AIMSHereditary transthyretin amyloidosis (ATTR) is a disabling and life-threatening disease that primarily affects the nervous system and heart. Its kidney involvement has been poorly studied and is not well known to nephrologists.METHODWe conducted a retrospective study (...)
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AbstractBACKGROUND AND AIMSGenetic etiologies are estimated to affect ?10% of adults with advanced CKD. However, significant population disparities in genetic kidney disease exist and population-based screening are lacking especially among minority groups. The Druze population is a (...)
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AbstractBACKGROUND AND AIMSAlthough discontinuation of antiplatelet agents at least 5 days before kidney biopsy is recommended by most guidelines and commonly advised by nephrologists, the evidence behind this practice is very low. Indeed, few non-randomized studies previously showed a similar (...)
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AbstractBACKGROUND AND AIMSSARS-CoV-2 pandemic is pressuring healthcare systems worldwide. Disease outcomes in certain subgroups of patients, such as nephropathic patients, are still scarce. Patients with chronic kidney disease (CKD) and on haemodialysis (HD) are at risk of a more severe (...)
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AbstractBACKGROUND AND AIMSPatients with end-stage kidney disease (ESKD) are at risk of coronavirus disease 2019 infection and its associated complications. A previous study demonstrated that patients with ESKD on dialysis generated suboptimal humoral immune response (HIR) and lower (...)
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AbstractBACKGROUND AND AIMSSortilin, an intracellular sorting receptor, has been identified as a cardiovascular (CV) risk factor in the general population. Patients with chronic kidney disease (CKD) are highly susceptible to developing CV complications such as CV calcification. However, (...)
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AbstractBACKGROUND AND AIMSLiving kidney donation is the preferred kidney replacement therapy considering graft function and survival rates. To donate a kidney is a life-changing experience, and there is a diverse spectrum of emotions connected to this process. The aim of this study was to (...)
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AbstractBACKGROUND AND AIMSmRNA-1273 vaccine (previously known as vaccine Moderna) has shown 94.1% efficacy at preventing COVID-19 illness in the general population. Vaccine-related adverse events (AEs) were usually mild or moderate in intensity and resolved within a few days. Nevertheless, the (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) represents the major postoperative long-term complication in patients who undergo radical nephrectomy (RN) for the presence of a renal mass. The development of a mild to severe grade of CKD can dramatically change the lifespan of this (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease–associated pruritus (CKD-aP) is common, yet underrecognized condition among end-stage kidney disease patients. We sought to evaluate the prevalence of CKD-aP and its impact on health-related quality of life (HRQOL) among dialysis patients across (...)
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AbstractBACKGROUND AND AIMSTo assess the level of renal inflammatory marker monocyte chemoattractant protein -1(MCP-1), measure the urinary MCP to urinary creatinine concentration ratio in morbidly obese patients before and after bariatric surgeries. To study if there any possible relation (...)
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AbstractBACKGROUND AND AIMSSoluble urokinase-type plasminogen activator receptor (suPAR) is associated with inflammation and contributing in the pathogenesis of atherosclerosis. Aortic stiffness is associated with aging-associated vascular diseases and is also an independent risk factor of (...)
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AbstractBACKGROUND AND AIMSHead and neck cancer (HNC) represents the sixth most common neoplasm worldwide, accounting for 400 000 deaths globally every year. Among HNC, the squamous cell carcinoma (SCCHN) is the most aggressive histology, being responsible for more than 90% of cases. The (...)
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AbstractBACKGROUND AND AIMSPatients with stage 4 chronic kidney disease (CKD) and type 2 diabetes (T2D) have a high residual risk of cardiovascular (CV) and kidney disease progression, and effective treatment options to reduce the risk are limited. The non-steroidal selective mineralocorticoid (...)
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AbstractBACKGROUND AND AIMSSodium zirconium cyclosilicate (SZC) is a novel, oral, highly selective potassium binder approved for the treatment of hyperkalaemia (HK) in adults. As well as binding potassium, SZC binds hydrogen ions in the acidic environment of the stomach, causing a transient (...)
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AbstractBACKGROUND AND AIMSIntravitreal administration of vascular endothelial growth factor (VEGF) inhibitors is the treatment of a wide variety of retinal diseases. Kidney damage caused by systemic administration is widely known. However, there is not enough information in the literature on (...)
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AbstractBACKGROUND AND AIMSNephrologists follow patients with chronic kidney disease (CKD) stage G3 and G4 as a homogeneous group with the assumption that everyone had similar rates of progression with scheduled visits and lab investigations based on the stage of the disease. We now recognize (...)
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AbstractBACKGROUND AND AIMSHaemolytic uremic syndrome (HUS) is a rare disease characterized by macroangiopathic haemolytic anaemia, thrombocytopaenia and severe AKI, belonging to the thrombotic microangiopathies (TMAs). It is divided into typical and atypical HUS: the first one occurs most (...)
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AbstractBACKGROUND AND AIMS Subjects with CKD carry a high (CV) risk. Whether this risk is blunted by aspirin is controversial. We examined CV outcomes of CKD participants of the TIPS3 trial.METHODThe International Polycap Study3 (TIPS3) randomized people (N = 5713) with and without CKD, but (...)
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AbstractBACKGROUND AND AIMSA renocardial comorbid condition with a combination of chronic kidney disease (CKD) and atrial fibrillation (AF) increases the risk of thromboembolic complications (TEC) and hemorrhagic events. As kidney function worsens, this risk only increases. Anticoagulant (...)
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AbstractBACKGROUND AND AIMSCOVID-19 infection in solid organ transplant recipients (SOT) is associated with increased morbidity and mortality due to comorbidities and immunosuppression state (Chaudhry ZS et al, 2020). Although vaccines represent the greatest hope to control COVID-19 pandemic, (...)
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AbstractBACKGROUND AND AIMSThe gut–kidney axis seems to have a principal role in immunoglobulin A nephropathy (IgAN) development [1], leading to new treatment approaches. Enteric budesonide, a glucocorticosteroid that release the active drug in the distal ileum, has proved proteinuria reduction (...)
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AbstractBACKGROUND AND AIMSIn daily clinical practice, an accurate assessment of renal function is of paramount importance in several categories of patients where the adequate medical or surgical treatment depends on the values of glomerular filtration rate (GFR). In particular, both (...)
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AbstractBACKGROUND AND AIMSPatients on haemodialysis (HD) are expected to have excess mortality in coronavirus disease 2019 (COVID-19). This was challenged by a recent study reporting HD patients to have comparable mortality and decreased ICU admissions when hospitalized with COVID-19. It was (...)
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AbstractBACKGROUND AND AIMSSystemic lupus erythematosus is the prototype of a multiorgan, multisystemic autoimmune disease. It has relatively frequent renal involvement (prevalence of 15–60%). A total of 19–25 patients develop end-stage renal disease after 10 years of disease onset. We studied (...)
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AbstractBACKGROUND AND AIMSThe prevalence of chronic kidney disease (CKD) in women of reproductive age continues to rise and reduced fertility is recognized even with mild disease. A greater proportion of women with CKD are seeking assisted reproductive technology (ART) treatment; however, our (...)
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AbstractBACKGROUND AND AIMSThe objectives of the present study are to compare the renal impairment between patients with SARS-COV-2 in two different time periods with dominant beta and delta SARS-COV-2 variants, with or without prior chronic kidney disease (CKD).METHODThe study was performed on (...)
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AbstractBACKGROUND AND AIMSThe use of iSGLT2 in people over 75 years was initially associated with a higher rate of adverse effects (AEs). Subsequent clinical trials have consistently demonstrated no increase of serious adverse effects in this group of patients, but the incidence of minor (...)
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AbstractBACKGROUND AND AIMSIndividuals hospitalized with hyperkalaemia (HK) and chronic kidney disease (CKD) are at very high risk of HK recurrence, which often requires hospital re-admission [1]. Recurrent HK events have a significant impact on healthcare resource utilization (HCRU) and costs (...)
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AbstractBACKGROUND AND AIMSHaemodialysis (HD) patients are at increased risk for adverse short-term consequences of COVID-19. In this study, we investigated the characteristics of chronic HD patients in the post-COVID-19 period and compared them with the control group.METHODWe conducted a (...)
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AbstractBACKGROUND AND AIMSCases of microangiopathy associated with COVID-19 are not fully understood. We aimed to clarify in these patients the presence of thrombotic microangiopathy (TMA) and decreased ADAMTS13 activity, the possible influence of these factors on kidney and lung damage, and (...)
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AbstractBACKGROUND AND AIMSChronic kidney disease (CKD) has been linked with an increased risk of cardiovascular events, especially in dialysis population. According to literature data, in the patients with CKD heart function disturbances are twice as common as in the general population [1]. (...)
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AbstractBACKGROUND AND AIMSAcute kidney injury (AKI) is increasingly common and associated with adverse short- and long-term outcomes in oncological patients who require radical nephrectomy (RN) for the presence of renal cancer. As defined by the KDIGO Criteria classification system, the (...)
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AbstractBACKGROUND AND AIMSChronic heart failure (CHF) is one of the most significant medical, economic and social problems of the 21st century. According to epidemiological studies, the prevalence of CHF in the USA and Western Europe ranges from 1.9% to 2.5% (Rosamond W. et al. 2007; Neumann (...)
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AbstractBACKGROUND AND AIMSResistivity index (RI) and pulsatility index (PI) are important Doppler ultrasound (US) parameters for the evaluation of intrarenal haemodynamics. One of the pathogenetic mechanism in diabetic nephropathy (DKD) is the arteriolar hyalinosis and the interlobar arteries (...)
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AbstractBACKGROUND AND AIMSProliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMIDs) is a recently described disease among the spectrum of monoclonal gammopathy of renal significance (MGRS). The disease is renal limited and manifests with chronic glomerular disease, (...)
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AbstractBACKGROUND AND AIMSProteinuria is strongly associated with the risk of CKD progression in non-diabetic and diabetic patients. SGLT2 inhibitors, as a promising new class, may provide protective effects for the kidney. Even though various studies have been conducted in this area, (...)
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AbstractBACKGROUND AND AIMSAngiopoietin-like protein 3 (ANGPTL3) plays important roles in lipid and lipoprotein trafficking and metabolism and has demonstrated a positive correlation with cardiovascular risk assessment parameters of carotid and femoral artery intima-media thickness. We (...)
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AbstractBACKGROUND AND AIMSLong-term oral anticoagulant should be recommended in patients with atrial fibrillation (AF) and CHA2DS2VASc score ? 1 for stroke prevention. Warfarin and different direct oral anticoagulants are metabolized differently by the kidney. The impact on renal function (...)
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AbstractBACKGROUND AND AIMSProgressive renal failure in patients with glomerular disease is driven by podocyte depletion. Several methods have been proposed to monitor urinary podocyte loss. Here, we investigated the process of podocyte depletion in patients with primary nephrotic syndrome (...)
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AbstractBACKGROUND AND AIMSAdipocyte fatty acid-binding protein (A-FABP) is expressed in adipocytes, dendritic cells and macrophages and it was thought to be involved in insulin resistance, chronic inflammation and atherosclerotic processes. Peripheral arterial disease (PAD) is associated with (...)
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AbstractBACKGROUND AND AIMSThe involvement of kidney in plasma cell dyscrasias is widespread, often referred to as myeloma kidney. At the time of presentation, nearly 50% of patients have renal involvement which is associated with higher mortality [1, 2]. Multiple myeloma is more common in (...)
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AbstractBACKGROUND AND AIMSEfficient antibiotic therapy remains the cornerstone of successful sepsis treatment. Urinary sepsis, which remains the most common sepsis type in kidney transplant recipients (KTRs), is characterized by high prevalence of multidrug-resistant (MDR) bacterial strains, (...)
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AbstractBACKGROUND AND AIMSTherapeutic plasma exchange (TPE) is an established therapy in the treatment of various immunologic kidney and neurological diseases. Humoral factors as antibodies, complement factors, cytokines and immune complexes, which all are assumed to play a role in (...)
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AbstractBACKGROUND AND AIMSTrimethylamine-N-oxide (TMAO) acts as an evident predictor for the prevalence of cardiovascular disease and increased incidence of major adverse cardiovascular events. Aortic stiffness predicts cardiovascular disease and is associated with ageing-associated vascular (...)
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AbstractBACKGROUND AND AIMSThe closure times [CTs; i.e. collagen/epinephrine (COL Epi) and collagen/adenosine 5-diphosphate (COL ADP)] are frequently used to evaluate primary haemostasis before kidney biopsy, although their usefulness to predict hemorrhagic events remains elusive [1]. CTs can (...)
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AbstractBACKGROUND AND AIMSThe immune system is affected by uremia. Haemodialysis (HD) patients have an increased risk of acquiring infections due to many healthcare contacts and have a suboptimal response to vaccination and a high mortality from COVID-19 infection. Accumulating data indicate (...)
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AbstractBACKGROUND AND AIMSThe new race-free estimated glomerular filtration rate (eGFR) was developed in 2021. Recently in the UK in keeping with similar initiatives elsewhere, the kidney failure risk equation (KFRE) to predict the risk of kidney failure has been incorporated into clinical (...)
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AbstractBACKGROUND AND AIMSAge-adapted thresholds of estimated glomerular filtration rate (eGFR) have been proposed for the diagnosis of chronic kidney disease (CKD) [1] to acknowledge decline in kidney function with increasing age [2]. Proponents of age-adapted thresholds suggest that subjects (...)
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AbstractBACKGROUND AND AIMSThe Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) recently developed a novel creatinine-based eGFR equation without a race coefficient. While American nephrology societies recommend using this novel equation, its implications are unknown.METHODWe (...)
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AbstractBACKGROUNDConventional stratification by clinical and histopathological phenotypes only approximates the heterogeneity of chronic kidney disease (CKD) and is insufficient to drive discovery of disease-modifying therapies or predict clinical outcomes. Recent advances in molecular (...)
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AbstractBACKGROUND AND AIMSHigh-intensity exercise modalities such as Crossfit have increased the number of practitioners due to the benefits such as weight loss. However, high-intensity exercise can induce renal and endothelial damage. The objective was to verify the main acute effects of (...)
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AbstractBACKGROUND AND AIMSStandard haemodialysis is associated with a considerable burden of intradialytic symptoms. Although haemodialysis with cool dialysate is associated with less intradialytic discomfort in general, the incidence of cold sensations increases significantly. Whether (...)
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AbstractBACKGROUND AND AIMSSarcoidosis (SCD) is a granulomatous disease that mostly affects young adults, presenting with hilar adenopathy, lung reticular opacities and skin/joint/eye lesions. Incidence varies in Europe between 0.3% and 1.5%, higher in southern countries. Up to one-third of (...)
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AbstractBACKGROUND AND AIMSHigh consumption of NaCl is traditionally considered the cardiovascular risk factor and the blood pressure (BP) growth factor. The considerable sodium content in the diet is associated with myocardium remodelling. Recently, attention has been also paid to studying the (...)
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AbstractBACKGROUND AND AIMSPlatinum-based agents are prescribed as backbone chemotherapy for lung, colorectal, esophagogastric, breast, testicular and ovarian cancers, among others. Renal excretion of platinum-based agents is mediated by the cellular transporters localized in renal tubules. (...)
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AbstractBACKGROUND AND AIMSCardiovascular disturbances are the most frequent cause of death in patients with chronic kidney disease (CKD). Various options of low protein diets (LPD) are widely used in CKD treatment. However, their role in cardioprotection at CKD is understudied. The aim was to (...)
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AbstractBACKGROUND AND AIMSThe prevalence of chronic kidney disease–associated pruritus (CKD-aP) found in different studies ranges from 40% to 90% in patients undergoing haemodialysis, and from 19% to 29% in non-dialysed patients. However, despite pruritus negatively affect the quality of life (...)
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AbstractBACKGROUND AND AIMSUbiquitous microthromboses in the pulmonary vasculature play a crucial role in the pathogenesis of COVID-19 associated acute respiratory distress syndrome (ARDS). Excess of von Willebrand factor (vWf) with intravascular multimer formation was identified as a key (...)
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AbstractBACKGROUND AND AIMSCOVID can affect many organs including kidneys involving various possible pathophysiological mechanisms [1]. Post-COVID conditions require focused approach for diagnosis, personalized treatments and rehabilitation. Ultrasonography (US) can provide accurate information (...)
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AbstractBACKGROUND AND AIMSEmphysematous pyelonephritis (EPN) is an acute and severe form of necrotizing infection of the renal parenchyma, collecting system and/or perinephric tissues, and it is characterized by accumulation of gas within these anatomic locations. Common presenting features (...)
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AbstractBACKGROUND AND AIMSThe aim of this study was to assess predictors of renal involvement and other factors secondary to FMF in renal and overall survival.METHODWe prospectively studied 57 Algerian patients admitted to our nephrology department from January 2012 to January 2021. The (...)
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AbstractBACKGROUND AND AIMSGait speed (GS) is an important measure of functional ability. The aim of this study was to investigate the factors associated with GS in patients with chronic kidney disease with respect to sarcopenic component, plasma uremic or inflammatory markers and quality of (...)
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AbstractBACKGROUND AND AIMSLipid abnormalities are a defining feature of nephrotic syndrome. In nephrotic patients, changes such as increased total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) and decreased high-density lipoprotein cholesterol (HDL-C) as (...)
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AbstractBACKGROUND AND AIMSHistopathology of renal parenchyma is the key diagnostic in the treatment of kidney diseases by nephrologists. Most nephrologists perform renal biopsy using percutaneous ultrasound-guided technic. Generally, this act is very simple for the majority of patients, but (...)
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AbstractBACKGROUND AND AIMSNeutrophils (Ns) play a key role in inflammation and tissue injury, in particular in acute renal failure, by releasing a complex of cytotoxic products such as reactive oxygen intermediates, enzymes and microbicidal polypeptides. These effects are prevented or (...)
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AbstractBACKGROUND AND AIMSDuring the time of the COVID-19 pandemic, multiple treatment options have been investigated, even though their efficacy and secondary effects remain insufficiently known.We report the case of a vitamin C induced oxalate nephropathy in a COVID-19 patient with (...)
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AbstractBACKGROUND AND AIMSPoint prevalence studies are observational studies, without intervention, and involve collecting data, in patients in multiple care units, at a specific time. It provides no information on outcomes but provides information on how common a problem is, and current (...)
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AbstractBACKGROUND AND AIMSAtrial fibrillation (AF) significantly increases the risk of developing end-stage chronic kidney disease (CKD). It should also be borne in mind that as kidney function deteriorates the risk of AF progression and its complications increases. Various studies have shown (...)
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AbstractBACKGROUND AND AIMSThe progressive increasing awareness of the need for a multidisciplinary management of cancer patients, the rapid development of new anti-cancer therapies, the prolongation of oncological patients’ survival and the increased incidence of chronic kidney disease (CKD) (...)
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AbstractBACKGROUND AND AIMSRenal failure severe enough to require dialysis is an independent predictor of poor survival outcomes in multiple myeloma (MM). Significant early mortality (EM) was also determined in patients with MM infected by COVID-19. To evaluate the EM rate and investigate the (...)
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AbstractBACKGROUND AND AIMSCardiorenal syndrome (CRS), defined as the spectrum of disorders that acutely or chronically affect both heart and kidney function, is often a challenging condition with paucity of evidence-based therapy. The increasing burden of this entity has prompted the creation (...)
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AbstractBACKGROUND AND AIMSPercutaneous biopsy is an important tool for monitoring renal allograft and early diagnosis when dysfunction occurs. Bleeding is the most dangerous adverse event, even if it is rare (risk of 0.5%). Cardiovascular (CV) disease affects 2/3 of elderly with CKD and (...)
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AbstractBACKGROUND AND AIMSPatients in haemodialysis are a vulnerable group, thought to have a poor antibody response to vaccination. In Denmark dialysis, patients were one of the first patient groups to be vaccinated against COVID-19. By investigating the antibody response of dialysis (...)
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AbstractBACKGROUND AND AIMSTo assess the role of urinary hemopexin in prediction of active lupus nephritis (LN) and correlate its level with disease activity and ability to predict response to induction therapy in Egyptian SLE patients with nephritis.METHODA cohort case-control hybrid study (...)
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AbstractBACKGROUND AND AIMSMembranous nephropathy is the most common cause of nephrotic syndrome in adults. However, the epidemiological data of this disease are not yet sufficiently known in our country. The aim of our study was to determine the clinical, biological and histological profile of (...)
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AbstractBACKGROUND AND AIMSWe aimed to evaluate the incidence and clinical features of patients with biopsy-proven dysproteinemic kidney diseases (group 1), as well as spectrum of biopsy-proven kidney diseases of patients with monoclonal gammopathy (MG) or abnormal free light chain (FLC) ratio (...)
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AbstractBACKGROUND AND AIMSUrinary retention is the inability to voluntarily pass a sufficient amount of urine [1]. This predominantly affects males often due to benign prostatic hyperplasia [1]. In patients with symptomatic urinary retention, initial management such as urethral catheter (...)
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AbstractBACKGROUND AND AIMSCalciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis, with high mortality and no proven therapy. Here, we reported multidisciplinary regenerative treatment for rescuing a severe uremic calciphylaxis patient with (...)
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AbstractBACKGROUND AND AIMSVasculitis constitutes a systemic disease with renal involvement at almost 100% in microscopic polyangiitis, 70–80% in granulomatosis with polyangitiis, 25% in eosinophilic granulomatosis with polyangitiis and 40–50% appears as renal limited vasculitis. In order to (...)
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AbstractBACKGROUND AND AIMSWe require an imagistic quantitative technique for the diagnosis and assessment of chronic kidney disease (CKD). Renal elastography has been widely used in the last years in different studies; however, the results across them are not consistent and, as a result, we (...)
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AbstractBACKGROUND AND AIMSElectrolyte abnormalities are common among patients with coronavirus disease 2019 (COVID-19). This study aims to investigate the electrolyte changes in severe and non-severe COVID-19 patients. Hypocalcaemia, hypomagnesaemia and hypoalbuminemia and their relationship (...)
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AbstractBACKGROUND AND AIMSPercutaneous renal biopsy is a fundamental technique for the diagnosis of numerous renal pathologies. However, it is an invasive technique that requires operator experience and is associated with adverse outcomes. Bleeding complications such as haematuria or perirenal (...)
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AbstractBACKGROUND AND AIMSCOVID-19 is an infection that has spread widely and quickly over the world, resulting in a pandemic with substantial consequences for the sociopolitical environment and healthcare delivery systems. The aim of this study was to explore the clinical, laboratory (...)
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AbstractBACKGROUND AND AIMSDespite impressive improvements in treatment strategies, heart failure (HF) morbidity and mortality remain substantially high worldwide. Muscle wasting is common and is associated with increased morbidity and mortality in patients with HF. The aim of the study was to (...)
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AbstractBACKGROUND AND AIMSAllopurinol is the first-line prescribed agent for hyperuricemia and gout. Allopurinol-induced drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but serious and potentially life-threatening drug hypersensitivity syndrome. This study aimed to (...)
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AbstractBACKGROUND AND AIMSSleep disorders, depression and anxiety are commonly reported in patients with systemic lupus erythematosus (SLE). Public health emergencies such as pandemics can also increase these psychosocial distresses. Early diagnosis and treatment of these disorders will (...)
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AbstractBACKGROUND AND AIMSTo evaluate the efficacy and safety of bortezomib combined with autologous stem cell transplantation (ASCT) in the treatment of monoclonal gammopathy of renal significance (MGRS).METHODThe clinicopathologic data of 16 patients with non-AL MGRS who received bortezomib (...)
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AbstractBACKGROUND AND AIMSImmune checkpoint inhibitors (CPIs)—a landmark in cancer therapy—has been occasionally associated with immune-related nephropathy [1]. Acute interstitial nephritis is considered to be the most common underlying histological entity, according to recent literature [2]. (...)
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AbstractBACKGROUND AND AIMSANCA vasculitis is a serious pathology and life threatening. Kidney damage is common. Few studies have focused on ANCA vasculitis in the elderly. The geriatric population is particular by its polypathology and its polypharmacy. Our objective was to detail the (...)
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AbstractBACKGROUND AND AIMSThe relationship between hyperuricaemia and renal cysts is still insufficient. Simple renal cysts (SRCs) are the most common non-hereditary type of benign renal cysts in adults. The prevalence of SRC varies by population, geographic region and the imaging modality (...)
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AbstractBACKGROUND AND AIMSLupus nephritis (LN) is one of the most serious manifestations of systemic lupus erythematosus (SLE), affecting mainly young women, but can also affect men. It refers to the development of intrarenal tissue inflammation responsible for various damage at this level: (...)
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AbstractBACKGROUNDAdvance care planning (ACP) enables competent patients to define goals and preferences for future treatments and care, to discuss these goals and preferences with relatives, and if appropriate to record these preferences [1]. After many years of political and social debates, (...)
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AbstractBACKGROUND AND AIMSVitamin D deficiency is associated with a higher mortality and incidence of cardiovascular disease. High brachial-ankle pulse wave velocity (baPWV) is independently associated with an increased risk of cardiovascular events, cardiovascular mortality and all-cause (...)
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AbstractBACKGROUND AND AIMSRenal manifestations are common in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report here the case of a patient with confirmed SARS-CoV-2 infection with the clinical picture of atypical haemolytic uremic syndrome (...)
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AbstractBACKGROUND AND AIMSElderly population is a vulnerable group, and cardiometabolic risk factors are highly prevalent among them. This situation complicates when the renal function becomes impaired. The aim of this study was to evaluate the association of renal function with (...)