7 February

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Recognition of Reviewers JCEM
  The editors of The Journal of Clinical Endocrinology & Metabolism thank all those who reviewed during 2022 for their time and effort.

30 December

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Correction to “Altered Intrinsic Brain Activity Related to Neurologic and Motor Dysfunction in Diabetic Peripheral Neuropathy Patients” JCEM
  In the above-named article by Xin H, Fu Y, Feng M, Wang S, Sui C, Gao Y, Zhang N, Guo L, Wen H, and Liang C (J Clin Endo Metab. 2022; 10.1210/clinem/dgac651), an error occurred in the Correspondence section and in the Acknowledgment (...)

22 December

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Correction to: “Management of Individuals With Diabetes at High Risk for Hypoglycemia: An Endocrine Society Clinical Practice Guideline” JCEM
  In the above-named article by McCall AL, Lieb DC, Gianchandani R, MacMaster H, Maynard GA, Murad MH, Seaquist E, Wolfsdorf JI, Wright RF, and Wiercioch W (J Clin Endo Metab. 2022; doi: 10.1210/clinem/dgac596), an error occurred in the list of co-sponsoring (...)

21 December

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  A Systematic Review Supporting the Endocrine Society Clinical Practice Guideline on the Treatment of Hypercalcemia of Malignancy in Adults JCEM
  AbstractContextHypercalcemia is a common complication of malignancy that is associated with high morbidity and mortality.ObjectiveTo support development of the Endocrine Society Clinical Practice Guideline for the treatment of hypercalcemia of malignancy in adults.MethodsWe searched multiple (...)
• 01:00
  Patient and Physician Decisional Factors Regarding Hypercalcemia of Malignancy Treatment: A Novel Mixed-Methods Study JCEM
  AbstractBackgroundIntegrating shared decision making between patients and physicians and incorporating their values and preferences in the development of clinical practice guidelines (CPGs) is of critical importance to optimize CPG implementation and treatment adherence. This applies to many (...)
• 01:00
  Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline JCEM
  AbstractBackgroundHypercalcemia of malignancy (HCM) is the most common metabolic complication of malignancies, but its incidence may be declining due to potent chemotherapeutic agents. The high mortality associated with HCM has declined markedly due to the introduction of increasingly effective (...)

17 December

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Correction to “Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets” JCEM
  In the above-named article by Tran DT, Pottekat A, Lee K, Raghunathan M, Loguercio S, Mir SA, Paton AW, Paton JC, Arvan P, Kaufman RJ, and Itkin-Ansari P (J Clin Endo Metab. 2022; 107(11): 3100-3110; 10.1210/clinem/dgac493), an error occurred in the Correspondence (...)

15 December

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Isolated Hypogonadotropic Hypogonadism: New Insights into Relationships Between Genotype and Reproductive Phenotype JCEM
  isolated hypogonadotropic hypogonadismgenotypephenotypeANOS1LHpuberty
• 01:00
  Osteoporosis Treatment: Decreased Mortality Too? JCEM
  osteoporosismortalitybisphosphonatesdenosumabfracture

14 December

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Correction to: “Cervical MUC5B and MUC5AC are Barriers to Ascending Pathogens During Pregnancy” JCEM
  In the above-named article by Ueda Y, Mogami H, Kawamura Y, Takakura M, Inohaya A, Yasuda E, Matsuzaka Y, Chigusa Y, Ito S, Mandai M, and Kondoh E (J Clin Endo Metab. 2022; 107(11): 3010–3021; doi: 10.1210/clinem/dgac545), there were errors in some of the figures as first (...)

13 December

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Correction to “Clinical, Endocrine and Neuroimaging Findings in Girls With Central Precocious Puberty” JCEM
  In the above-named article by Fava D, Calandrino A, Calevo MG, Allegri AEM, Napoli F, Gastaldi R, Patti G, Casalini E, Bassi M, Accogli A, Alyasin ARAA, Ramaglia A, Rossi A, Maghnie M, Morana G, and Di Iorgi N (J Clin Endo Metab. 2022; 107(10): e4132–e4143; doi: 10.1210/clinem/dgac422), a funder (...)
• 01:00
  Correction to “Understanding Pathogenesis Intersects With Effective Treatment for Thyroid Eye Disease” JCEM
  In the above-named article by Smith TJ (J Clin Endo Metab. 2022; 107:s13-s26; doi: 10.1210/clinem/dgac328), two errors appeared in the published paper:
• 01:00
  Correction to “Implication of MR Activity in Posttreatment Arterial Stiffness Reversal in Patients With Primary Aldosteronism” JCEM
  In the above-named article by Chen ZW, Pan CT, Liao CW, Tsai CH, Chang YY, Chang CC, Lee BC, Chiu YW, Huang WC, Wang SM, Lu CC, Chueh JS, Wu VC, Hung CS, and Lin YH (J Clin Endo Metab. 2022; 10.1210/clinem/dgac649), an error occurred in the affiliation (...)

12 December

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  GLP-1 Receptor Agonists and SGLT-2 Inhibitors as Adjuncts to Insulin in Type 1 Diabetes: Benefits and Concerns JCEM
  GLP-1 receptor agonistsSGLT2 inhibitorstype 1 diabetesreal-world outcomessafetyefficacy?

8 December

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  New Horizons: Artificial Intelligence Tools for Managing Osteoporosis JCEM
  AbstractOsteoporosis is a disease characterized by low bone mass and microarchitectural deterioration leading to increased bone fragility and fracture risk. Typically, osteoporotic fractures occur at the spine, hip, distal forearm, and proximal humerus, but other skeletal sites may be affected (...)
• 01:00
  Letter to the Editor from Han and Xu: “Association Between DPP4 Inhibitor Use and the Incidence of Cirrhosis, ESRD, and Some Cancers in Patients With Diabetes” JCEM
  Dipeptidyl peptidase 4 inhibitor (DPP4i) is considered the “smartest hypoglycemic drug” and was found to inhibit tumor growth. Recently, a national study from Na et al reported that patients with diabetes undergoing DPP4i treatment had a higher risk of liver cirrhosis and cancer, end-stage renal (...)

7 December

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Response to Letter to the Editor From Han and Xu: “Association Between DPP4 Inhibitor Use and the Incidence of Cirrhosis, ESRD, and Some Cancers in Patients With Diabetes” JCEM
  Dear Editor,
• 01:00
  A Systematic Review Supporting the Endocrine Society Guidelines: Management of Diabetes and High Risk of Hypoglycemia JCEM
  AbstractContextInterventions targeting hypoglycemia in people with diabetes are important for improving quality of life and reducing morbidity and mortality.ObjectiveTo support development of the Endocrine Society Clinical Practice Guideline for management of individuals with diabetes at high (...)
• 01:00
  Management of Individuals With Diabetes at High Risk for Hypoglycemia: An Endocrine Society Clinical Practice Guideline JCEM
  AbstractContextHypoglycemia in people with diabetes is common, especially in those taking medications such as insulin and sulfonylureas (SU) that place them at higher risk. Hypoglycemia is associated with distress in those with diabetes and their families, medication nonadherence, and (...)

5 December

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Targeting PCSK9 With Antibodies and Gene Silencing to Reduce LDL Cholesterol JCEM
  AbstractThe discovery of PCSK9 and its role in regulating the low-density lipoprotein (LDL) receptor, and the effect of loss-of-function mutations of its gene, identified it as a therapeutic target in 2006. Fully humanized monoclonal antibodies to PCSK9 (alirocumab and evolocumab) proved (...)
• 01:00
  Response to Letter to the Editor From Sumi et al: “Lower Bone Turnover and Skeletal PTH Responsiveness in Japanese Compared to European Patients Receiving Hemodialysis” JCEM
  European Renal AssociationERA10.13039/100015682The Kidney Foundation, JapanJKFB 20-18
• 01:00
  Letter to the Editor From Sumi et al.: “Lower Bone Turnover and Skeletal PTH Responsiveness in Japanese Compared to European Patients Receiving Hemodialysis” JCEM
  hemodialysisskeletal PTH responsivenessbone turnovertarget PTH levelsJSDT guidelineKDIGO guideline

1 December

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  IGF-1/IGFBP-3 Serum Ratio as a Robust Measure to Determine GH Deficiency and Guide Human Recombinant GH Therapy JCEM
  small for gestational agegrowth hormone deficiencyinsulin growth factor-1IGF-1insulin-like growth factor binding protein-3IGF-1 lifetime exposure
• 01:00
  Correction to “Bone health in adults with Prader-Willi syndrome: clinical recommendations based on a multicenter cohort study” JCEM
  In the above-named article by van Abswoude DH, Pellikaan K, Hoshino Y, Rosenberg AGW, Davidse K, Coupaye M, Høybye C, Markovic TP, Grugni G, Crinò A, Caixàs A, Poitou C, Mosbah H, Weir T, van Vlimmeren LA, Rutges JPHJ, De Klerk LWL, Zillikens MC, van der Lely AJ, and de Graaff LCG (J Clin Endo (...)
• 01:00
  Correction to “Machine Learning-Based Prediction of Elevated PTH Levels Among the US General Population” JCEM
  In the above-named article by Kato H, Hoshino Y, Hidaka N, Ito N, Makita N, Nangaku M, and Inoue K (J Clin Endo Metab. 2022; doi:10.1210/clinem/dgac544), an error occurred in the funding statement:

24 November

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Reduced Intestinal Calcium Absorption Correlates With Bone Loss After Sleeve Gastrectomy: Implications for Clinical Care JCEM
  calcium absorptionbariatric surgerysleeve gastrectomycalcium supplementation
• 01:00
  DNA Methylation in Autoimmune Thyroid Disease JCEM
  AbstractGraves disease and Hashimoto disease form part of the spectrum of autoimmune thyroid disease (AITD), to which genetic and environmental factors are recognized contributors. Epigenetics provides a potential link between environmental influences, gene expression, and thyroid autoimmunity. (...)

21 November

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Approach to the Patient With Adrenal Hemorrhage JCEM
  AbstractAdrenal hemorrhage is an uncommon, underrecognized condition that can be encountered in several clinical contexts. Diagnosing adrenal hemorrhage is challenging due to its nonspecific clinical features. Therefore, it remains a diagnosis that is made serendipitously on imaging of acutely (...)

16 November

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Efficacy and Safety of Tyrosine Kinase Inhibitors in Patients with Metastatic Pheochromocytomas/Paragangliomas JCEM
  AbstractContextTyrosine kinase inhibitors (TKIs) can be used to treat locally unresectable or distantly metastatic pheochromocytomas/paragangliomas (PPGLs), such as sunitinib, according to the National Comprehensive Cancer Network guidelines in 2022. However, the precise effect of different (...)

15 November

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  New Hope for a Tumor-Directed Therapy for Cushing Disease JCEM
  Cushing diseasepituitary disease
• 01:00
  Pancreas Transplantation: Current Challenges, Considerations, and Controversies JCEM
  AbstractPancreas transplantation (PTx) reestablishes an autoregulating source of endogenous insulin responsive to normal feedback controls. In addition to achieving complete ?-cell replacement that frees the patient with diabetes from the need to monitor serum glucose and administer exogenous (...)

14 November

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Metabolomics to Assess Thyroid Hormone Status? JCEM
  metabolomicslevothyroxinehypothyroidismpersonalized treatment
• 01:00
  Circulating Bile Acids as Biomarkers for Disease Diagnosis and Prevention JCEM
  AbstractContextBile acids (BAs) are pivotal signaling molecules that regulate energy metabolism and inflammation. Recent epidemiological studies have reported specific alterations in circulating BA profiles in certain disease states, including obesity, type 2 diabetes mellitus (T2DM), (...)
• 01:00
  Exclusion Tests in Unilateral Primary Aldosteronism (ExcluPA) Study JCEM
  AbstractContextDetermining the diagnostic accuracy of “exclusion” tests for primary aldosteronism (PA) compared to the aldosterone to renin ratio (ARR) is fundamental to avoid invasive subtyping in false-positive patients at screening.ObjectiveTo assess the accuracy of exclusion tests for PA (...)

11 November

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Screening for Adverse Metabolic Consequences in Women With Idiopathic Hirsutism—Is it Relevant? JCEM
  hirsutismmetabolic healthdyslipidemiahypertensionhyperglycemiainsulin resistancecardiovascular risk

10 November

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Approach to the Patient With Short Stature: Genetic Testing JCEM
  AbstractThe first step in the evaluation of the short child is to decide whether growth parameters in the context of the history are abnormal or a variant of normal. If growth is considered abnormal, system and hormonal tests are likely to be required, followed by more directed testing, such as (...)
• 01:00
  Changing the Name of Diabetes Insipidus: A Position Statement of the Working Group for Renaming Diabetes Insipidus JCEM
  AbstractRecent data show that patients with a diagnosis of diabetes insipidus (DI) are coming to harm. Here we give the rationale for a name change to arginine vasopressin deficiency and resistance for central and nephrogenic DI, (...)

5 November

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  The First Compound Heterozygous Mutations of DMP1 Causing Rare Autosomal Recessive Hypophosphatemic Rickets Type 1 JCEM
  AbstractContextHereditary hypophosphatemic rickets (HR) consists of a group of inherited hypophosphatemia due to mutations of different genes, which need genetic analysis to make a differential diagnosis. Among them, autosomal recessive hypophosphatemic rickets type 1 (ARHR1), caused by a (...)
• 01:00
  Altered Intrinsic Brain Activity Related to Neurologic and Motor Dysfunction in Diabetic Peripheral Neuropathy Patients JCEM
  AbstractContextBrain functional alterations in type 2 diabetes with diabetic peripheral neuropathy (DPN) related to motor dysfunction remain largely unknown.ObjectiveWe aimed to explore intrinsic resting brain activity in DPN.MethodsA total of 28 patients with DPN, 43 patients with diabetes and (...)
• 01:00
  Implication of MR Activity in Posttreatment Arterial Stiffness Reversal in Patients With Primary Aldosteronism JCEM
  AbstractContextPrimary aldosteronism (PA) patients have a higher degree of arterial stiffness, which can be reversed after adrenalectomy.ObjectiveWe aimed to compare the reversal of arterial stiffness between surgically and medically treated PA patients and to identify the predictors of (...)

4 November

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Is Sleep the Best Medicine? JCEM
  visceral adipose tissuesleepobesity
• 01:00
  Approach to the Patient With a Suppressed TSH JCEM
  AbstractSubclinical hyperthyroidism (SCH) is a laboratory diagnosis defined by a serum thyrotropin (TSH) concentration below the reference range (< 0.4 mU/L in most assays), and a free thyroxine (FT4) and 3,5,3?-triiodothyronine levels (FT3) in the reference range. Many patients diagnosed (...)
• 01:00
  Current Controversies in Low-Risk Differentiated Thyroid Cancer: Reducing Overtreatment in an Era of Overdiagnosis JCEM
  AbstractContextLow-risk differentiated thyroid cancer (DTC) is overdiagnosed, but true incidence has increased as well. Owing to its excellent prognosis with low morbidity and mortality, balancing treatment risks with risks of disease progression can be challenging, leading to several areas of (...)

2 November

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Genotype-phenotype Description of Vitamin D–dependent Rickets 1A: CYP27B1 p.(Ala129Thr) Variant Induces a Milder Disease JCEM
  AbstractIntroductionVitamin D–dependent rickets type 1A (VDDR1A) is a rare genetic disease associated with loss-of-function variations in the gene encoding the vitamin D–activating enzyme 1?-hydroxylase (CYP27B1). Phenotype-genotype correlation is unclear. Long-term outcome data are lacking. The (...)

1 November

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Comparisons Between Different Anti-osteoporosis Medications on Postfracture Mortality: A Population-Based Study JCEM
  AbstractContextOsteoporosis is becoming a global epidemic in aging societies. Anti-osteoporotic medications can prevent fractures, and their pleiotropic effect on mortality is interesting but not well compared among each other.ObjectiveTo provide real-world evidence on the pleiotropic effect of (...)
• 01:00
  Delays in Surgery for Differentiated Thyroid Carcinomas: How Long Is Reasonable, and What Questions Remain? JCEM
  Papillary thyroid carcinoma is the most common type of thyroid cancer and is known to have excellent outcomes with standard of care treatment. The last decade has brought about societal guidelines recommending active surveillance for certain very low risk tumors, including papillary (...)
• 01:00
  Islet Inflammation Can Be Linked to the Disruption of Proinsulin Processing in Type 1 Diabetes but not in Type 2 Diabetes JCEM
  type 1 diabetestype 2 diabetesproinsulininflammationbeta cell
• 01:00
  Body Weight Variability and Cardiovascular Health in Diabetes JCEM
  BMIvariabilitydiabetescardiovascular

31 October

JCEM https://academic.oup.com/rss/site_5591/

• 01:00
  Skeletal Effects of Sleeve Gastrectomy in Adolescents and Young Adults: A 2-Year Longitudinal Study JCEM
  AbstractContextVertical sleeve gastrectomy (VSG) is an increasingly common tool to achieve weight loss and improve metabolic health in adolescents and young adults with obesity, although it may adversely affect bone health.ObjectiveThis work aimed to evaluate the effect of VSG on bone health in (...)
• 01:00
  Data Mining Framework for Discovering and Clustering Phenotypes of Atypical Diabetes JCEM
  AbstractContextSome individuals present with forms of diabetes that are “atypical” (AD), which do not conform to typical features of either type 1 diabetes (T1D) or type 2 diabetes (T2D). These forms of AD display a range of phenotypic characteristics that likely reflect different endotypes based (...)
• 01:00
  Correction to “Reduced Sensitivity to Thyroid Hormones Is Associated With High Remnant Cholesterol Levels in Chinese Euthyroid Adults” JCEM
  In the above-named article by Sun H, Zhu W, Liu J, An Y, Wang Y, and Wang G ( J Clin Endo Metab. 2022; 10.1210/clinem/dgac523), an error occurred in the author list:

28 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Lifestyle Interventions Reduce the Risk of Type 2 Diabetes Through Decreasing Branched-Chain Amino Acids: Newer Insights JCEM
  branched-chain amino acidstype 2 diabetes mellituslifestyle interventionmetabolome
• 02:00
  It's Not Just About the Hot Flashes: Menopausal Hormone Changes and Disrupted Sleep JCEM
  Sleep disturbances are common during the menopausal transition, being reported by more than half of midlife women (1). Women are particularly plagued by middle-of-the-night awakenings as they progress through the menopausal transition (2). These sleep disturbances diminish quality of life, work (...)
• 02:00
  Approach to the Patient With Nonalcoholic Fatty Liver Disease JCEM
  AbstractContextNonalcoholic fatty liver disease (NAFLD) is associated with obesity and type 2 diabetes (T2D), causing substantial burden from hepatic and extrahepatic complications. However, endocrinologists often follow people who are at the highest risk of its more severe form with (...)

27 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Teprotumumab-Related Hyperglycemia JCEM
  AbstractContextGraves orbitopathy (GO) or thyroid eye disease is a potentially sight-threatening and disfiguring autoimmune disease. Teprotumumab is a monoclonal antibody against the insulin-like growth factor-I receptor that was recently approved for GO treatment. Hyperglycemia is a recognized (...)
• 02:00
  Disorders of Salt and Water Balance After Pituitary Surgery JCEM
  AbstractTranssphenoidal surgery is the first-line treatment for many clinically significant pituitary tumors and sellar lesions. Although complication rates are low when performed at high-volume centers, disorders of salt and water balance are relatively common postoperatively. Both, or either, (...)
• 02:00
  Response to Letter to the Editor From Nelson et al: “Understanding the Link Between Obesity and Severe COVID-19 Outcomes: Causal Mediation by Systemic Inflammatory Response” JCEM
  We agree fully with Nelson et al (1) that rigor in the analysis of sex is critically important in studies of severe outcomes associated with SARS-CoV-2 infection, and particularly in investigations of obesity, inflammation, and the mechanistic underpinnings of severe disease. Indeed, in tandem (...)

26 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  The Acute Cytokine Response to 30-Minute Exercise Bouts Before and After 8-Week Endurance Training in Individuals With Obesity JCEM
  AbstractContextOne acute bout of exercise leads to a rapid increase in the systemic cytokine concentration. Regular exercise might alter the cytokine response, in particular in beforehand untrained and obese individuals.ObjectiveUsing a proximity extension assay, we studied the effects of acute (...)
• 02:00
  From the Full KIGS Cohort: On Safety and Efficacy of Growth Hormone Treatment JCEM
  growth hormoneefficacysafetyshort stature

24 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Effect of Dapagliflozin on Cardiac Function and Metabolic and Hormonal Responses to Exercise JCEM
  AbstractObjectiveThis work aimed to investigate the effect of the SGLT2 inhibitor, dapagliflozin (DAPA), on cardiac function and the metabolic and hormonal response to moderate exercise in people with type 2 diabetes.MethodsThis was a double-blind, placebo-controlled crossover study with a (...)
• 02:00
  Survivin: A Potential Marker of Resistance to Somatostatin Receptor Ligands JCEM
  AbstractContextInvasive and somatostatin receptor ligand (SRL)-resistant pituitary tumors represent a challenge in the clinical practice of endocrinologists. Efforts have been made to elucidate reliable makers for both. Survivin and eukaryotic translation initiation factor-binding protein 1 (...)

21 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Clinical and Safety Outcomes With GLP-1 Receptor Agonists and SGLT2 Inhibitors in Type 1 Diabetes: A Real-World Study JCEM
  AbstractContextGlucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) are used off-label in the management of type 1 diabetes mellitus (T1DM) in real-world practice as adjuvant therapies to insulin. There are few real-world data regarding (...)
• 02:00
  Sex Differences in Phosphate Homeostasis: Females Excrete More Phosphate and Calcium After an Oral Phosphate Challenge JCEM
  AbstractContextDietary consumption of phosphate is increasing, and elevated serum phosphate is associated with increased cardiovascular disease (CVD) risk. Sex differences in phosphate homeostasis and response to changes in dietary phosphate intake, which are not captured by clinically measured (...)
• 02:00
  Reproductive Phenotypes and Genotypes in Men With IHH JCEM
  AbstractContextIsolated hypogonadotropic hypogonadism (IHH) is phenotypically and genetically heterogeneous.ObjectiveThis work aimed to determine the correlation between genotypic severity with pubertal and neuroendocrine phenotypes in IHH men.MethodsA retrospective study was conducted (...)
• 02:00
  Letter to the Editor From Nelson et al: “Understanding the Link Between Obesity and Severe COVID-19 Outcomes: Causal Mediation by Systemic Inflammatory Response” JCEM
  We have read and appreciate the hypothesis and excellent data collected and analyzed to show that inflammation related to obesity is associated with increased severity of COVID-19 illness (1). The COVID-19 pandemic has illustrated and exacerbated existing inequalities in health and well-being. (...)

20 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Association Between Systemic Lupus Erythematosus and Primary Hypothyroidism: Evidence from Complementary Genetic Methods JCEM
  AbstractIntroductionSystemic lupus erythematosus (SLE) and hypothyroidism often coexist in observational studies; however, the causal relationship between them remains controversial.MethodsComplementary genetic approaches, including genetic correlation, Mendelian randomization (MR), and (...)
• 02:00
  Differences in Inflammatory Pathways Between Dutch South Asians vs Dutch Europids With Type 2 Diabetes JCEM
  AbstractContextSouth Asian individuals are more prone to develop type 2 diabetes (T2D) coinciding with earlier complications than Europids. While inflammation plays a central role in the development and progression of T2D, this factor is still underexplored in South Asians.ObjectiveThis work (...)
• 02:00
  Impaired Cognitive Function in Patients With Autonomous Cortisol Secretion in Adrenal Incidentalomas JCEM
  AbstractContextGlucocorticoids have potent effects on the central nervous system. However, while patients with Cushing syndrome frequently report impairments in cognitive function, studies investigating cognitive function in patients with autonomous cortisol secretion (ACS) in adrenal (...)
• 02:00
  Correction to “New Horizons: Revival of Lipoprotein (a) as a Risk Factor for Cardiovascular Disease” JCEM
  In the above-named article by Nestel P, Loh WJ, Ward NC, and Watts GF (J Clin Endo Metab. 2022; doi: 10.1210/clinem/dgac541), an error occurred in placement of the Figure 2 and Figure 3 images:

19 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men JCEM
  AbstractIntroductionAgeing skeletal muscles become both insulin resistant and atrophic. The hormone glucagon-like peptide 1 (GLP-1) facilitates postprandial glucose uptake as well as augmenting muscle perfusion, independent of insulin action. We thus hypothesized exogenous GLP-1 infusions would (...)
• 02:00
  The Association of Inflammatory Factors With Peripheral Neuropathy: The Study of Women's Health Across the Nation JCEM
  AbstractPurposePrevious work has focused on the role of diabetes in peripheral neuropathy (PN), but PN often occurs before, and independently from, diabetes. This study measures the association of cardiometabolic and inflammatory factor with PN, independent of diabetes.MethodsStudy of Women's (...)
• 02:00
  Autopsy Study of Testicles in COVID-19: Upregulation of Immune-Related Genes and Downregulation of Testis-Specific Genes JCEM
  AbstractContextInfection by SARS-CoV-2 may be associated with testicular dysfunction that could affect male fertility.ObjectiveTesticles of fatal COVID-19 cases were investigated to detect virus in tissue and to evaluate histopathological and transcriptomic changes.MethodsThree groups were (...)
• 02:00
  Correction to: “Pharmacologic Weight Management in the Era of Adolescent Obesity” JCEM
  In the above-named article by Raman V, Gupta A, Ashraf AP, Breidbart E, Gourgari E, Kamboj M, Kohn B, Krishnan S, Lahoti A, Matlock K, Mehta S, Mistry S, Miller R, Page L, Reynolds D, and Han JC (J Clin Endo Metab. 2022; 107(10); doi: 10.1210/clinem/dgac418), approved updates were not (...)

17 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Serum IGF-1 to IGFBP-3 Molar Ratio: A Promising Diagnostic Tool for Growth Hormone Deficiency in Children JCEM
  AbstractBackgroundThe serum insulin-like growth factor-1 (IGF-1)/insulin-like growth factor binding protein-3 (IGFBP-3) ratio has various potential applications in growth hormone-related disorders. This study aimed to investigate the performance of the IGF-1/IGFBP-3 ratio, independently and in (...)
• 02:00
  New Onset or Deterioration of Thyroid Eye Disease After mRNA SARS-CoV-2 Vaccines: Report of 2 Cases and Literature Review JCEM
  AbstractContextOccurrence of Graves’ disease (GD) has been reported following SARS-CoV-2 vaccine administration, but little is known about thyroid eye disease (TED) after SARS-CoV-2 vaccination.ObjectiveWe describe 2 cases of TED activation following mRNA SARS-CoV-2 vaccination and review (...)
• 02:00
  Tracking and Cumulative Lifetime Exposure to IGF-I in 6459 Healthy Individuals and in SGA Children Treated With GH JCEM
  AbstractContextSupraphysiological serum insulin-like growth factor-I (IGF-I) concentrations have been a matter of concern in children treated with GH because high IGF-I levels were associated with risk of later disease in former epidemiological studies.ObjectiveTo determine whether a single (...)
• 02:00
  Utility of In Vivo Magnetic Resonance Imaging Is Predictive of Gestational Diabetes Mellitus During Early Pregnancy JCEM
  AbstractContextGestational diabetes (GDM) imposes long-term adverse health effects on the mother and fetus. The role of magnetic resonance imaging (MRI) during early gestation in GDM has not been well-studied.ObjectiveTo investigate the role of quantitative MRI measurements of placental volume (...)
• 02:00
  Understanding Prenatal and Postnatal Linear Growth JCEM
  SGAAGALGAbirth weightcatchup growthshort staturegrowth trajectory
• 02:00
  Correction to: “Associations of Serum Vitamin B6 Status and Catabolism With All-Cause Mortality in Patients With T2DM” JCEM
  In the above-named article by Zhang D, Li Y, Lang X, and Zhang Y (J Clin Endo Metab. 2022; 107(10); doi: 10.1210/clinem/dgac429), an error appeared in the Conclusions section:

14 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Ketone Body Infusion Abrogates Growth Hormone–Induced Lipolysis and Insulin Resistance JCEM
  AbstractContextExogenous ketone body administration lowers circulating glucose levels but the underlying mechanisms are uncertain.ObjectiveWe tested the hypothesis that administration of the ketone body ?-hydroxybutyrate (?OHB) acutely increases insulin sensitivity via feedback suppression of (...)
• 02:00
  Hyperinsulinemic Hypoglycemia Diagnosed in Childhood Can Be Monogenic JCEM
  AbstractContextCongenital hyperinsulinism (HI) is characterized by inappropriate insulin secretion despite low blood glucose. Persistent HI is often monogenic, with the majority of cases diagnosed in infancy. Less is known about the contribution of monogenic forms of disease in those presenting (...)
• 02:00
  Low Gestational Weight Gain in Women With Gestational Diabetes Is Safe With Better Metabolic Profile Postpartum JCEM
  AbstractContextMore data are needed on the potential benefits and risks of gestational weight gain (GWG) less than recommended and excessive GWG in women with gestational diabetes (GDM) compared to women with normal glucose tolerance (NGT) during pregnancy.ObjectiveThis work aimed to evaluate (...)

13 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Risk Modeling to Reduce Monitoring of an Autoantibody-Positive Population to Prevent DKA at Type 1 Diabetes Diagnosis JCEM
  AbstractContextThe presence of islet autoimmunity identifies individuals likely to progress to clinical type 1 diabetes (T1D). In clinical research studies, autoantibody screening followed by regular metabolic monitoring every 6 months reduces incidence of diabetic ketoacidosis (DKA) at (...)
• 02:00
  Twelve Loci Associated With Bone Density in Middle-aged and Elderly Chinese: The Shanghai Changfeng Study JCEM
  AbstractContextPrevious genome-wide association studies (GWASs) of bone mineral density (BMD) were mainly conducted in Europeans.ObjectiveTo explore genetic variants that affect BMD and sex differences in a Chinese population.MethodsA total of 5428 middle-aged and elderly Chinese were included. (...)
• 02:00
  Radioactive Iodine-Refractory Pulmonary Metastases of Papillary Thyroid Cancer in Children, Adolescents, and Young Adults JCEM
  AbstractContextFew studies have explored radioactive iodine–refractory (RAIR) disease in children, adolescents, and young adults with papillary thyroid cancer (CAYA-PTC).ObjectiveThis study systematically investigated the clinicopathologic characteristics and prognosis of CAYA-PTC with RAIR (...)

12 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Implications of an HbA1c-based Diabetes Screening on Prevalence and Effect of Dysglycemia in Patients With COVID-19 JCEM
  AbstractContextIn patients with severe acute respiratory syndrome coronavirus type 2 infection, diabetes is associated with poor COVID-19 prognosis. However, case detection strategy is divergent and reported prevalence varies from 5% to 35%.ObjectiveWe examined how far the choice of screening (...)

11 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Hypoglycemia Caused by Exogenous Insulin Antibody Syndrome: A Large Single-Center Case Series From China JCEM
  AbstractContextExogenous insulin antibody syndrome (EIAS) can lead to unexpected and potentially life-threatening recurrent hypoglycemia.ObjectiveWe aimed to better define autoimmune hypoglycemia caused by EIAS in patients with diabetes and shed light on the improvements in the identification (...)
• 02:00
  Glycemic Gap Predicts Mortality in a Large Multicenter Cohort Hospitalized With COVID-19 JCEM
  AbstractContextDiabetes or hyperglycemia at admission are established risk factors for adverse outcomes during hospitalization for COVID-19, but the impact of prior glycemic control is not clear.ObjectiveWe aimed to examine the associations between admission variables, including glycemic gap, (...)
• 02:00
  Regional Variation in Hormonal and Metabolic Parameters of White and Black Women With PCOS in the United States JCEM
  AbstractContextOngoing research is needed to determine geo-epidemiologic differences of polycystic ovary syndrome (PCOS).ObjectiveDetermine hormonal and metabolic parameters of women with PCOS in 2 environments.MethodsProspective cohort study.SettingTertiary-care based specialty clinics in (...)
• 02:00
  Sodium-Glucose Cotransporter 2 Inhibitors and New-onset Type 2 Diabetes in Adults With Prediabetes: Systematic Review and Meta-analysis of Randomized Controlled Trials JCEM
  AbstractContextThe preventive effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors for new-onset diabetes was investigated in secondary analyses of several randomized controlled trials (RCTs). However, the results were inconsistent.ObjectiveThis work aimed to synthesize available (...)

10 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Treatment of Cushing Disease With Pituitary-Targeting Seliciclib JCEM
  AbstractContextPreclinical studies show seliciclib (R-roscovitine) suppresses neoplastic corticotroph proliferation and pituitary adrenocorticotrophic hormone (ACTH) production.ObjectiveTo evaluate seliciclib as an effective pituitary-targeting treatment for patients with Cushing disease (...)
• 02:00
  Metabolomic Profile of Children Conceived With Medically Assisted Technologies JCEM
  AbstractContextAssisted reproductive technologies (ART) and non–in vitro fertilization fertility treatments (NIFT) are treatments for infertility. These technologies may have long-term health effects in children such as increased hypertension, glucose intolerance, and hypertriglyceridemia. Few (...)

7 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Association of Complement C3 With Incident Type 2 Diabetes and the Mediating Role of BMI: A 10-Year Follow-Up Study JCEM
  AbstractContextImpairment of immune and inflammatory homeostasis is reported to be one of the causal factors of diabetes. However, the association of complement C3 levels with incident diabetes in humans remains unclear.ObjectiveThis study aimed to examine the association between C3 levels and (...)
• 02:00
  Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials JCEM
  AbstractContextPrevious meta-analyses have suggested that the effects of coenzyme Q10 (CoQ10) on lipid profiles remain debatable. Additionally, no meta-analysis has explored the optimal intake of CoQ10 for attenuating lipid profiles in adults.ObjectiveThis study conducted a meta-analysis to (...)

6 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  General Comorbidity Indicators Contribute to Fracture Risk Independent of FRAX: Registry-Based Cohort Study JCEM
  AbstractContextFRAX® estimates 10-year fracture probability from osteoporosis-specific risk factors. Medical comorbidity indicators are associated with fracture risk but whether these are independent from those in FRAX is uncertain.ObjectiveWe hypothesized Johns Hopkins Aggregated Diagnosis (...)
• 02:00
  Obesity, Overweight, and Pituitary Stalk Interruption Syndrome in Children and Young Adults JCEM
  AbstractContextPituitary stalk interruption syndrome (PSIS) is rare in the pediatric population. It combines ectopic posterior pituitary stalk interruption and anterior pituitary hypoplasia with hormonal deficiencies. The phenotype is highly heterogeneous and obesity/overweight seems to be (...)
• 02:00
  Changes in Serum Testosterone and Adrenal Androgen Levels in Transgender Women With and Without Gonadectomy JCEM
  AbstractBackgroundInitiating feminizing gender-affirming hormone therapy (GAHT) in transgender women causes a steep decline in serum testosterone. It is unknown if testosterone concentrations change further and whether adrenal androgen levels change during feminizing GAHT and after gonadectomy. (...)

5 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Maternal Thyroid Dysfunction and Neuropsychological Development in Children JCEM
  AbstractContextThyroid hormones are essential for fetal brain development. The potential effects of maternal gestational thyroid dysfunction on offspring neuropsychological development remain inconclusive.ObjectiveThis work aimed to estimate effects of maternal thyroid dysfunction during (...)
• 02:00
  Diabetes Mellitus is Associated With Higher Serum Neurofilament Light Chain Levels in the General US Population JCEM
  AbstractContextSerum neurofilament light chain (sNfL) levels are biomarkers of neuroaxonal injury in multiple neurological diseases.ObjectiveGiven the paucity of data on the distribution of sNfL levels in the general population, in the present study we identified predictors of sNfL levels in a (...)
• 02:00
  Intestinal Calcium Absorption Decreases After Laparoscopic Sleeve Gastrectomy Despite Optimization of Vitamin D Status JCEM
  AbstractContextLaparoscopic sleeve gastrectomy (LSG), now the most commonly performed bariatric operation, is a highly effective treatment for obesity. While Roux-en-Y gastric bypass is known to impair intestinal fractional calcium absorption (FCA) and negatively affect bone metabolism, LSG's (...)

3 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  A Low-Frequency APOB p.(Pro955Ser) Variant Contributes to the Severity of/Variability in Familial Hypercholesterolemia JCEM
  AbstractContextHeterozygous familial hypercholesterolemia (HeFH) is caused by a rare pathogenic variant in the LDLR, APOB, and PCSK9 genes. However, the causative variants in these genes have not been identified in approximately 40% of HeFH patients.ObjectiveOur aim was to identify novel (or (...)
• 02:00
  Just as Tall on Testosterone; a Neutral to Positive Effect on Adult Height of GnRHa and Testosterone in Trans Boys JCEM
  AbstractContextGrowth is an important topic for many transgender boys. However, few studies have investigated the impact of puberty suppression (PS) and gender-affirming hormone treatment (GAHT) on growth and adult height.ObjectiveTo evaluate the effect of PS and GAHT on growth and adult (...)
• 02:00
  Targeting Tumor Hypoxia Inhibits Aggressive Phenotype of Dedifferentiated Thyroid Cancer JCEM
  AbstractContextHypoxia is commonly observed in multiple aggressive cancers. Its role remains unclear in the biology and therapy of dedifferentiated thyroid cancer (DDTC).ObjectiveWe aimed to elucidate hypoxia's roles in DDTC tumor biology.MethodsWe discovered and confirmed hypoxia's correlation (...)
• 02:00
  Recurrent Disease in Patients With Sporadic Pheochromocytoma and Paraganglioma JCEM
  AbstractContextLong-term follow-up has been recommended for patients with pheochromocytoma or paraganglioma (PPGL) due to potential for recurrent disease. However, the need to follow patients with sporadic PPGL has recently become controversial.ObjectiveTo investigate the prevalence of (...)
• 02:00
  Novel Causal Plasma Proteins for Hypothyroidism: A Large-scale Plasma Proteome Mendelian Randomization Analysis JCEM
  AbstractContextAlthough several risk proteins for hypothyroidism have been reported in recent years, many more plasma proteins have not been tested.ObjectiveTo determine potential mechanisms and novel causal plasma proteins for hypothyroidism using Mendelian randomization (MR).MethodsA (...)
• 02:00
  Age at Menarche Mediating Visceral Adipose Tissue's Influence on Pre-eclampsia: A Mendelian Randomization Study JCEM
  AbstractContextThe association between visceral adipose tissue (VAT) and pre-eclampsia (PE) shows inconsistent results and the underlying mediator remains unknown.ObjectiveWe aimed to explore the causal effect of VAT on PE risks and the mediation role of age at menarche (AAM) in explaining this (...)
• 02:00
  Statins, Type 2 Diabetes, and Body Mass Index: A Univariable and Multivariable Mendelian Randomization Study JCEM
  AbstractContextStatins and possibly other lipid modifiers increase type 2 diabetes risk and body mass index (BMI). However, to what extent BMI mediates the diabetogenic effects of lipid modifiers remains unclear.ObjectiveWe used Mendelian randomization (MR) to investigate the effects of (...)

1 October

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Nonalcoholic Fatty Liver Disease and Adverse Pregnancy Outcomes in Women With Normal Prepregnant Weight JCEM
  AbstractContextExisting studies focusing on the effects of nonalcoholic fatty liver disease (NAFLD) combined with normal prepregnant weight on pregnancy outcomes are limited.ObjectiveThis study aimed to explore the relationship between maternal NAFLD and adverse pregnancy outcomes in different (...)
• 02:00
  Metabolic Dysregulation in Adult Survivors of Pediatric Hematopoietic Stem Cell Transplantation: The Role of Incretins JCEM
  AbstractContextSurvivors of pediatric hematopoietic stem cell transplantation (HSCT) have increased risk of developing metabolic syndrome (MetS), but the mechanisms are poorly understood.ObjectiveWe aimed to test the hypothesis that insufficient secretion of glucagon-like peptide-1 (GLP-1) and (...)
• 02:00
  Leukocyte Telomere Length in Children With Congenital Adrenal Hyperplasia JCEM
  AbstractContextExposure to chronic stress and hypercortisolism is associated with decreased leukocyte telomere length (LTL), a marker for biological aging and cardiovascular disease. Children with congenital adrenal hyperplasia (CAH) are treated with glucocorticoids.ObjectiveTo investigate LTL (...)
• 02:00
  NIFTP Statistics—Now You See It, Now You Don’t JCEM
  NIFTPthyroid cancerthyroid nodulesincidence
• 02:00
  Plasma Metabolomics Reveals Systemic Metabolic Alterations of Subclinical and Clinical Hypothyroidism JCEM
  AbstractContextClinical hypothyroidism (CH) and subclinical hypothyroidism (SCH) have been linked to various metabolic comorbidities but the underlying metabolic alterations remain unclear. Metabolomics may provide metabolic insights into the pathophysiology of hypothyroidism.ObjectiveWe (...)
• 02:00
  Liraglutide for Weight Management in Children and Adolescents With Prader–Willi Syndrome and Obesity JCEM
  AbstractContextPrader–Willi syndrome (PWS) is characterized by lack of appetite control and hyperphagia, leading to obesity. Pharmacological options for weight management are needed.ObjectiveTo determine whether liraglutide treatment for weight management is superior to placebo/no treatment in (...)

30 September

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Genetic Dissection of Primary Aldosteronism in a Patient With MEN1 and Ipsilateral Adrenocortical Carcinoma and Adenoma JCEM
  AbstractBackgroundAdrenal tumors are found in up to 40% of patients with multiple endocrine neoplasia type 1 (MEN1). However, adrenocortical carcinomas (ACC) and primary aldosteronism (PA) are rare in MEN1.CaseA 48-year-old woman known to have primary hyperparathyroidism and hypertension with (...)
• 02:00
  Aldosterone, Renin, and Aldosterone-to-Renin Ratio Variability in Screening for Primary Aldosteronism JCEM
  AbstractContextThe plasma aldosterone concentration (PAC), renin, and aldosterone-to-renin ratio (ARR) are used to screen for primary aldosteronism (PA). Substantial intra-individual variability of PAC and ARR using plasma renin activity in the context of usual antihypertensive therapy has been (...)

29 September

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Differences in HDL-Bound Apolipoproteins in Patients With Advanced Liver Fibrosis Due to Nonalcoholic Fatty Liver Disease JCEM
  AbstractContextThe mechanisms leading to increased cardiovascular disease in patients with nonalcoholic fatty liver disease (NAFLD) and advanced liver fibrosis remain incompletely understood.ObjectiveThis study assessed HDL-bound proteins in patients with NAFLD with or without advanced (...)

23 September

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Bone Health in Adults With Prader–Willi Syndrome: Clinical Recommendations Based on a Multicenter Cohort Study JCEM
  AbstractContextPrader–Willi syndrome (PWS) is a rare complex genetic syndrome, characterized by delayed psychomotor development, hypotonia, and hyperphagia. Hormone deficiencies such as hypogonadism, hypothyroidism, and growth hormone deficiency are common. The combination of hypotonia, low (...)
• 02:00
  Novel Variants and Phenotypes in NEUROG3-Associated Syndrome JCEM
  AbstractContextBiallelic pathogenic variants in the NEUROG3 gene cause malabsorptive diarrhea, insulin-dependent diabetes mellitus (IDDM), and rarely hypogonadotropic hypogonadism. With only 17 reported cases, the clinical and mutational spectra of this disease are far from complete.ObjectiveTo (...)

22 September

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Maternal Glycaemic and Insulinemic Status and Newborn DNA Methylation: Findings in Women With Overweight and Obesity JCEM
  AbstractContextMaternal dysglycaemia and prepregnancy obesity are associated with adverse offspring outcomes. Epigenetic mechanisms such as DNA methylation (DNAm) could contribute.ObjectiveTo examine relationships between maternal glycaemia, insulinemic status, and dietary glycemic indices (...)
• 02:00
  Lower Blood Oxygen Saturation is Associated With Microvascular Complications in Individuals With Type 1 Diabetes JCEM
  AbstractContextBlood oxygen saturation (SpO2) is lower in type 1 diabetes (T1D) compared with nondiabetic controls. Hypoxia (low tissue oxygenation) is thought to be a risk factor for progression of diabetic complications, but it is unknown whether hypoxemia (low SpO2) is associated with (...)
• 02:00
  Finding the Balance on Extent of Initial Thyroidectomy for Low-Risk Papillary Thyroid Carcinoma JCEM
  thyroid neoplasmspapillary thyroid cancerthyroidectomy

21 September

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Distinct Clinical Features of Post-COVID-19 Vaccination Early-onset Graves’ Disease JCEM
  AbstractContextSeveral case reports of Graves’ disease (GD) occurrence after COVID-19 vaccination that are possibly related to the autoimmune syndrome induced by adjuvants (ASIA) were published recently.ObjectiveThe aim of our study was to evaluate possible distinctive features in the (...)

20 September

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Idiopathic Hirsutism and Metabolic Status: A Population-based Prospective Cohort Study JCEM
  AbstractBackgroundA limited number of studies have investigated the impact of idiopathic hirsutism (IH) on cardiometabolic parameters with contradictory and inconclusive results. This study aimed to explore the effect of IH on metabolic outcomes.MethodIn this population-based prospective study, (...)

14 September

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Prenatal Dexamethasone Treatment of Congenital Adrenal Hyperplasia: Are We Any Closer to Considering It Safe? JCEM
  congenital adrenal hyperplasiaprenatal dexamethasone treatmentbrain function
• 02:00
  Evaluating the Progression to Hypothyroidism in Preconception Euthyroid Thyroid Peroxidase Antibody–Positive Women JCEM
  AbstractContextThyroid peroxidase antibody (TPOAb) positivity is prevalent in women of reproductive age and predisposes to thyroid dysfunction, particularly hypothyroidism, which has adverse effects on pregnancy.ObjectiveThis study aimed to report the rate of development of abnormal thyroid (...)

13 September

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Low Thrombin Generation in Users of a Contraceptive Containing Estetrol and Drospirenone JCEM
  AbstractObjectiveTo compare the impact on thrombin generation of the new combined oral contraceptive containing 15 mg estetrol and 3 mg drospirenone with ethinylestradiol (30 or 20 mcg) associated either with 150 mcg levonorgestrel or with 3 mg drospirenone.MethodsData were collected from the (...)

9 September

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Twin Study: Genetic and Epigenetic Factors Affecting Circulating Adiponectin Levels JCEM
  AbstractContextClarification of the association among phenotypes, genetic, and environmental factors with clinical laboratory traits can reveal the cause of diseases and assist in developing methods for the prediction and prevention of diseases. It is difficult to investigate the environmental (...)

8 September

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Variety and Quantity of Dietary-Insoluble Fiber Intake From Different Sources and Risk of New-Onset Diabetes JCEM
  AbstractContextThe relationship between the variety and quantity of different sources of dietary-insoluble fiber intake and diabetes remain uncertain.ObjectiveWe aimed to investigate the associations between the variety and quantity of insoluble fiber intake from 6 major food sources and (...)
• 02:00
  Long-term Burosumab Administration Is Safe and Effective in Adults With X-linked Hypophosphatemia JCEM
  AbstractContextBurosumab was developed as a treatment option for patients with the rare, lifelong, chronically debilitating, genetic bone disease X-linked hypophosphatemia (XLH).ObjectiveCollect additional information on the safety, immunogenicity, and clinical response to long-term (...)
• 02:00
  Reduced Sensitivity to Thyroid Hormones Is Associated With High Remnant Cholesterol Levels in Chinese Euthyroid Adults JCEM
  AbstractContextIt remains unclear whether the thyroid system could regulate the atherogenic remnant cholesterol (RC) levels in euthyroid status.ObjectiveWe aimed to investigate the relationship between sensitivity to thyroid hormones and RC levels in Chinese euthyroid population.MethodsThis (...)

3 September

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Inpatient Zoledronic Acid and Integrated Orthopedic and Fracture Liaison Services Improve Osteoporosis Treatment Rates JCEM
  AbstractContextFragility fractures increase risks for future fractures, morbidity, and mortality. Available pharmacotherapy for underlying osteoporosis is safe and effective but underused.ObjectiveTo improve pharmacotherapy rate representing secondary prevention of osteoporotic (...)
• 02:00
  Dysbetalipoproteinemia Is Associated With Increased Risk of Coronary and Peripheral Vascular Disease JCEM
  AbstractContextDysbetalipoproteinemia (DBL) is a disorder in which remnant lipoproteins accumulate in the plasma due to a genetic apolipoprotein E dysfunction in conjunction with the presence of secondary metabolic factors. An increased risk of both coronary and peripheral vascular disease (...)

18 August

JCEM https://academic.oup.com/rss/site_5591/

• 02:00
  Approach to Hypophosphatemic Rickets JCEM
  AbstractHypophosphatemic rickets typically presents in infancy or early childhood with skeletal deformities and growth plate abnormalities. The most common causes are genetic (such as X-linked hypophosphatemia), and these typically will result in lifelong hypophosphatemia and osteomalacia. (...)