24 January

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] Performance of cardiovascular disease risk prediction equations in more than 14 000 survivors of cancer in New Zealand primary care: a validation study - Essa Tawfiq, Vanessa Selak, J Mark Elwood, Romana Pylypchuk, Sandar Tin Tin, Matire Harwood, Corina Grey, Mark McKeage, Sue Wells Lancet - cardiovascular
  The New Zealand cardiovascular disease risk prediction equations reasonably predicted the observed 5-year cardiovascular disease risk in survivors of cancer in the country, in whom risk prediction was considered clinically appropriate. Prediction could be improved by adding cancer-specific (...) (The Lancet (2023))

12 January

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Seminar] Acute aortic dissection - Thierry Carrel, Thoralf M Sundt, Yskert von Kodolitsch, Martin Czerny Lancet - cardiovascular
  Although substantial progress has been made in the prevention, diagnosis, and treatment of acute aortic dissection, it remains a complex cardiovascular event, with a high immediate mortality and substantial morbidity in individuals surviving the acute period. The past decade has allowed a leap (...) (The Lancet (2023))

28 December

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:12
  [Review] Acylations in cardiovascular biology and diseases, what's beyond acetylation - Xin Sun, Yang Zhang, Xiao-Feng Chen, Xiaoqiang Tang Lancet - cardiovascular
  Metabolism regulates cardiovascular biology through multiple mechanisms, including epigenetic modifications. Over the past two decades, experimental and preclinical studies have highlighted the critical roles of histone modifications in cardiovascular development, homeostasis, and diseases. The (...) (eBioMedicine 87, (2023))

21 December

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] Machine learning-based marker for coronary artery disease: derivation and validation in two longitudinal cohorts - Iain S Forrest, Ben O Petrazzini, Áine Duffy, Joshua K Park, Carla Marquez-Luna, Daniel M Jordan, Ghislain Rocheleau, Judy H Cho, Robert S Rosenson, Jagat Narula, Girish N Nadkarni, Ron Do Lancet - cardiovascular
  Electronic health record-based machine learning was used to generate an in-silico marker for coronary artery disease that can non-invasively quantify atherosclerosis and risk of death on a continuous spectrum, and identify underdiagnosed (...) (The Lancet 401, 10372 (2023))

10 December

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Series] Racism, xenophobia, and discrimination: mapping pathways to health outcomes - Sujitha Selvarajah, Susanna Corona Maioli, Thilagawathi Abi Deivanayagam, Priscila de Morais Sato, Delan Devakumar, Seung-Sup Kim, Jonathan C Wells, Marcella Yoseph, Ibrahim Abubakar, Yin Paradies Lancet - cardiovascular
  Despite being globally pervasive, racism, xenophobia, and discrimination are not universally recognised determinants of health. We challenge widespread beliefs related to the inevitability of increased mortality and morbidity associated with particular ethnicities and minoritised groups. In (...) (The Lancet 400, 10368 (2022))

1 December

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Articles] Tobacco smoking and risks of more than 470 diseases in China: a prospective cohort study - Ka Hung Chan, Neil Wright, Dan Xiao, Yu Guo, Yiping Chen, Huaidong Du, Ling Yang, Iona Y Millwood, Pei Pei, Junzheng Wang, Iain Turnbull, Simon Gilbert, Daniel Avery, Christiana Kartsonaki, Canqing Yu, Junshi Chen, Jun Lv, Robert Clarke, Rory Collins, Richard Peto, Liming Li, Chen Wang, Zhengming Chen, China Kadoorie Biobank collaborative group Lancet - cardiovascular
  Among Chinese adults, smoking was associated with higher risks of morbidity and mortality from a wide range of diseases. Among men, the future smoking-attributed disease burden will increase further, highlighting a pressing need for reducing consumption through widespread cessation and uptake (...) (The Lancet Public Health 7, 12 (2022))
• 00:00
  [Articles] Cardiovascular disease prevention and mortality across 1 million urban populations in China: data from a nationwide population-based study - Xingyi Zhang, Jiapeng Lu, Yang Yang, Jianlan Cui, Xiaoyan Zhang, Wei Xu, Lijuan Song, Chaoqun Wu, Qing Wang, Yunfeng Wang, Runsi Wang, Xi Li Lancet - cardiovascular
  New-urban in situ residents and rural-to-urban migrants both showed poorer utilisation of primary and secondary prevention medications than did old-urban in situ residents, while new-urban in situ residents also had lower adherence to healthy lifestyles and higher death risks. Comprehensive (...) (The Lancet Public Health 7, 12 (2022))
• 00:00
  [Articles] Influenza vaccine to reduce adverse vascular events in patients with heart failure: a multinational randomised, double-blind, placebo-controlled trial - Mark Loeb, Ambuj Roy, Hisham Dokainish, Antonio Dans, Lia M Palileo-Villanueva, Kamilu Karaye, Jun Zhu, Yan Liang, Fastone Goma, Albertino Damasceno, Khalid F Alhabib, Gerald Yonga, Charles Mondo, Wael Almahmeed, Arif Al Mulla, Vitheya Thanabalan, Purnima Rao-Melacini, Alex Grinvalds, Tara McCready, Shrikant I Bangdiwala, Salim Yusuf, Influenza Vaccine to Prevent Adverse Vascular Events investigators Lancet - cardiovascular
  Although the prespecified co-primary outcomes during the entire period of observation were not statistically significant, the reduction during the peak influenza circulating period suggests that there is likely to be a clinical benefit of giving influenza vaccine, given the clear reduction in (...) (The Lancet Global Health 10, 12 (2022))

26 November

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] Intensive compared with less intensive blood pressure control to prevent adverse cardiac remodelling in children with chronic kidney disease (HOT-KID): a parallel-group, open-label, multicentre, randomised, controlled trial - Manish D Sinha, Haotian Gu, Abdel Douiri, Janette Cansick, Eric Finlay, Rodney Gilbert, Larissa Kerecuk, Andrew Lunn, Heather Maxwell, Henry Morgan, Mohan Shenoy, Rukshana Shroff, Pushpa Subramaniam, Jane Tizard, Yincent Tse, Reza Rezavi, John M Simpson, Phil J Chowienczyk, HOT-KID study Lancet - cardiovascular
  These results suggest that cardiac remodelling in children with chronic kidney disease is related to blood pressure control and that a target office systolic blood pressure at the 50th percentile is close to the optimal target for preventing increased left ventricular (...) (The Lancet Child & Adolescent Health 7, 1 (2023))

14 November

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:15
  [Articles] Diminished arachidonate 5-lipoxygenase perturbs phase separation and transcriptional response of Runx2 to reverse pathological ventricular remodeling - Saiyang Xie, Mengya Chen, Wenxi Fang, Shiqiang Liu, Qingqing Wu, Chen Liu, Yun Xing, Wenke Shi, Man Xu, Min Zhang, Si Chen, Xiaofeng Zeng, Shasha Wang, Wei Deng, Qizhu Tang Lancet - cardiovascular
  Overall, our study demonstrated that targeting Alox5 exerted a protective effect against cardiac remodeling and heart failure under hypertensive stimuli by disturbing LLPS of Runx2 and substantial reduction of EGFR transcription activation in cardiomyocytes. Our findings suggest that negative (...) (eBioMedicine 86, (2022))

11 November

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Comment] Reduction in heart failure outcomes with SGLT2 inhibitors irrespective of glycaemic status - Hertzel C Gerstein, Naveed Sattar Lancet - cardiovascular
  Dysglycaemia is a metabolic state characterised by an HbA1c level above the normal range and includes anyone with slightly elevated glucose concentrations, impaired fasting glucose, impaired glucose tolerance, or diabetes. Since the term was first coined in 1996,1 analyses of many prospective (...) (The Lancet Diabetes & Endocrinology 10, 12 (2022))
• 00:30
  [Articles] Efficacy and safety of dapagliflozin in patients with heart failure with mildly reduced or preserved ejection fraction by baseline glycaemic status (DELIVER): a subgroup analysis from an international, multicentre, double-blind, randomised, placebo-controlled trial - Silvio E Inzucchi, Brian L Claggett, Muthiah Vaduganathan, Akshay S Desai, Pardeep S Jhund, Rudolf A de Boer, Adrian F Hernandez, Mikhail N Kosiborod, Carolyn S P Lam, Felipe Martinez, Sanjiv J Shah, Subodh Verma, Yaling Han, Jose F Kerr Saraiva, Olof Bengtsson, Magnus Petersson, Anna Maria Langkilde, John J V McMurray, Scott D Solomon Lancet - cardiovascular
  In patients with heart failure with mildly reduced or preserved ejection fraction, oral dapagliflozin improved heart failure outcomes to a similar extent in three glycaemia subgroups: normoglycaemia, prediabetes, and type 2 diabetes. Moreover, the heart failure benefits of dapagliflozin seem to (...) (The Lancet Diabetes & Endocrinology 10, 12 (2022))

7 November

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 15:40
  [Articles] Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial - Alexandre Mebazaa, Beth Davison, Ovidiu Chioncel, Alain Cohen-Solal, Rafael Diaz, Gerasimos Filippatos, Marco Metra, Piotr Ponikowski, Karen Sliwa, Adriaan A Voors, Christopher Edwards, Maria Novosadova, Koji Takagi, Albertino Damasceno, Hadiza Saidu, Etienne Gayat, Peter S Pang, Jelena Celutkiene, Gad Cotter Lancet - cardiovascular
  An intensive treatment strategy of rapid up-titration of guideline-directed medication and close follow-up after an acute heart failure admission was readily accepted by patients because it reduced symptoms, improved quality of life, and reduced the risk of 180-day all-cause death or heart (...) (The Lancet 400, 10367 (2022))

5 November

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 21:39
  [Articles] Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial - Paul R Kalra, John G F Cleland, Mark C Petrie, Elizabeth A Thomson, Philip A Kalra, Iain B Squire, Fozia Z Ahmed, Abdallah Al-Mohammad, Peter J Cowburn, Paul W X Foley, Fraser J Graham, Alan G Japp, Rebecca E Lane, Ninian N Lang, Andrew J Ludman, Iain C Macdougall, Pierpaolo Pellicori, Robin Ray, Michele Robertson, Alison Seed, Ian Ford, IRONMAN Study Group Lancet - cardiovascular
  For a broad range of patients with heart failure, reduced left ventricular ejection fraction and iron deficiency, intravenous ferric derisomaltose administration was associated with a lower risk of hospital admissions for heart failure and cardiovascular death, further supporting the benefit of (...) (The Lancet 400, 10369 (2022))
• 00:00
  [Articles] Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial - Chris Hawkey, Anthony Avery, Carol A C Coupland, Colin Crooks, Jennifer Dumbleton, F D Richard Hobbs, Denise Kendrick, Michael Moore, Clive Morris, Gregory Rubin, Murray Smith, Diane Stevenson, HEAT Trialists Lancet - cardiovascular
  H pylori eradication protects against aspirin-associated peptic ulcer bleeding, but this might not be sustained in the long term. (The Lancet 400, 10363 (2022))

1 November

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Articles] Air quality and the risk of out-of-hospital cardiac arrest in Singapore (PAROS): a time series analysis - Andrew Fu Wah Ho, Jamie S Y Ho, Benjamin Yong-Qiang Tan, Seyed Ehsan Saffari, Jun Wei Yeo, Ching-Hui Sia, Meng Wang, Joel Aik, Huili Zheng, Geoffrey Morgan, Wilson Wai San Tam, Wei Jie Seow, Marcus Eng Hock Ong, PAROS Singapore Investigators Lancet - cardiovascular
  Increases in PM2·5 concentration were associated with an initial increased risk of OHCA and a subsequent reduced risk from 3–5 days after exposure, suggesting a short-term harvesting effect. A decrease in PM2·5 concentrations could reduce population demand for emergency health (...) (The Lancet Public Health 7, 11 (2022))

30 October

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:11
  [Articles] A systematic review and meta-analysis of intraday effects of ambient air pollution and temperature on cardiorespiratory morbidities: First few hours of exposure matters to life - Keyu Wu, Hung Chak Ho, Hong Su, Cunrui Huang, Hao Zheng, Wenyi Zhang, Junwen Tao, Mohammad Zahid Hossain, Yunquan Zhang, Kejia Hu, Min Yang, Qiyue Wu, Zhiwei Xu, Jian Cheng Lancet - cardiovascular
  This study supports a sudden risk increase of cardiorespiratory diseases within a few hours after exposure to air pollution or heat, and some acute and highly lethal diseases such as myocardial infarction and cardiac arrest could be affected within a shorter (...) (eBioMedicine 86, (2022))

27 October

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:13
  [Review] Atrial fibrillation: Insights from animal models, computational modeling, and clinical studies - Carolyna Yamamoto, Natalia A. Trayanova Lancet - cardiovascular
  Atrial fibrillation (AF) is the most common human arrhythmia, affecting millions of patients worldwide. A combination of risk factors and comorbidities results in complex atrial remodeling, which increases AF vulnerability and persistence. Insights from animal models, clinical studies, and (...) (eBioMedicine 85, (2022))

22 October

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 10:41
  [Viewpoint] Scalable hypertension management tools in communities based on novel technologies in China - Shengshou Hu Lancet - cardiovascular
  China has entered a transitional time in the health of its population and the capacity of its health care system to address the country's changing needs. Prior successes in socioeconomic development have led to a large and growing elderly population, as well as rising rates of non-communicable (...) (The Lancet Regional Health – Western Pacific 29, (2022))

12 October

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:13
  [Articles] Age, sex, race, BMI, and duration of diabetes differences in cardiovascular outcomes with glucose lowering drugs in type 2 diabetes: A systematic review and meta-analysis - Alhassane Diallo, Miguel Carlos-Bolumbu, Florence Galtier Lancet - cardiovascular
  In patients with type 2 diabetes at highest risk of cardiovascular disease or established cardiovascular disease, a greater benefit on MACE was found for elderly patients and for Asian individuals compared with White individuals with GLP-1 RAs, and those with a long duration of diabetes with (...) (eClinicalMedicine 54, (2022))
• 00:30
  [Articles] Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial - Isla S Mackenzie, Amy Rogers, Neil R Poulter, Bryan Williams, Morris J Brown, David J Webb, Ian Ford, David A Rorie, Greg Guthrie, J W Kerr Grieve, Filippo Pigazzani, Peter M Rothwell, Robin Young, Alex McConnachie, Allan D Struthers, Chim C Lang, Thomas M MacDonald, TIME Study Group Lancet - cardiovascular
  Evening dosing of usual antihypertensive medication was not different from morning dosing in terms of major cardiovascular outcomes. Patients can be advised that they can take their regular antihypertensive medications at a convenient time that minimises any undesirable (...) (The Lancet 400, 10361 (2022))

1 October

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 10:00
  [Articles] Predicted heart age profile across 41 countries: A cross-sectional study of nationally representative surveys in six world regions - Wilmer Cristobal Guzman-Vilca, Gustavo A. Quispe-Villegas, Rodrigo M. Carrillo-Larco Lancet - cardiovascular
  PHA is generally higher than chronological age in LMICs and there are regional disparities. Most people with excess PHA would not be eligible to receive preventive medication. (eClinicalMedicine 52, (2022))
• 00:00
  [Articles] Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial - Tilman Reiff, Hans-Henning Eckstein, Ulrich Mansmann, Olav Jansen, Gustav Fraedrich, Harald Mudra, Dittmar Böckler, Michael Böhm, E Sebastian Debus, Jens Fiehler, Klaus Mathias, Erich B Ringelstein, Jürg Schmidli, Robert Stingele, Ralf Zahn, Thomas Zeller, Wolf-Dirk Niesen, Kristian Barlinn, Andreas Binder, Jörg Glahn, Werner Hacke, Peter Arthur Ringleb, for the SPACE-2 Investigators Lancet - cardiovascular
  CEA plus BMT or CAS plus BMT were not found to be superior to BMT alone regarding risk of any stroke or death within 30 days or ipsilateral stroke during the 5-year observation period. Because of the small sample size, results should be interpreted with (...) (The Lancet Neurology 21, 10 (2022))

29 September

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Personal View] Glucose-lowering drugs with cardiovascular benefits as modifiers of critical elements of the human life history - Angelo Avogaro, Saula Vigili de Kreutzenberg, Mario Luca Morieri, Gian Paolo Fadini, Stefano Del Prato Lancet - cardiovascular
  The life history theory assumes that all organisms are under selective pressure to harvest external resources and allocate them to maximise fitness: only organisms making the best use of energy obtain the greatest fitness benefits. The trade-off of energy spans four functions: maintenance, (...) (The Lancet Diabetes & Endocrinology 10, 12 (2022))

17 September

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:15
  [Review] Therapeutic strategies in ischemic cardiomyopathy: Focus on mitochondrial quality surveillance - Xing Chang, Sam Toan, Ruibing Li, Hao Zhou Lancet - cardiovascular
  Despite considerable efforts to prevent and treat ischemic cardiomyopathy (ICM), effective therapies remain lacking, in part owing to the complexity of the underlying molecular mechanisms, which are not completely understood yet. It is now widely thought that mitochondria serve as “sentinel” (...) (eBioMedicine 84, (2022))

10 September

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Articles] Metabolic, behavioural, and psychosocial risk factors and cardiovascular disease in women compared with men in 21 high-income, middle-income, and low-income countries: an analysis of the PURE study - Marjan Walli-Attaei, Annika Rosengren, Sumathy Rangarajan, Yolandi Breet, Suraya Abdul-Razak, Wadeia Al Sharief, Khalid F Alhabib, Alvaro Avezum, Jephat Chifamba, Rafael Diaz, Rajeev Gupta, Bo Hu, Romaina Iqbal, Rosnah Ismail, Roya Kelishadi, Rasha Khatib, Xinyue Lang, Sidong Li, Patricio Lopez-Jaramillo, Viswanathan Mohan, Aytekin Oguz, Lia M Palileo-Villanueva, Katarzyna Poltyn-Zaradna, Sreelakshmi P R, Lakshmi V M Pinnaka, Pamela Serón, Koon Teo, Sejil T Verghese, Andreas Wielgosz, Karen Yeates, Rita Yusuf, Sonia S Anand, Salim Yusuf, PURE (...) Lancet - cardiovascular
  Lipid markers and depression are more strongly associated with the risk of cardiovascular disease in men than in women, whereas diet is more strongly associated with the risk of cardiovascular disease in women than in men. The similar associations of other risk factors with cardiovascular (...) (The Lancet 400, 10355 (2022))

6 September

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Comment] PCSK9 inhibition in children with familial hypercholesterolaemia - Robert A Hegele Lancet - cardiovascular
  Heterozygous familial hypercholesterolaemia is the most prevalent monogenic dyslipidaemia, affecting approximately 1 in 300 people worldwide.1 If left untreated, elevated LDL cholesterol concentrations in heterozygous familial hypercholesterolaemia are associated with a more than ten-fold (...) (The Lancet Diabetes & Endocrinology 10, 10 (2022))
• 00:30
  [Articles] Paediatric patients with heterozygous familial hypercholesterolaemia treated with evolocumab for 80 weeks (HAUSER-OLE): a single-arm, multicentre, open-label extension of HAUSER-RCT - Raul D Santos, Andrea Ruzza, G Kees Hovingh, Claudia Stefanutti, François Mach, Olivier S Descamps, Jean Bergeron, Bei Wang, Andrea Bartuli, Paola Sabrina Buonuomo, Susanne Greber-Platzer, Ilse Luirink, Ajay K Bhatia, Frederick J Raal, John J P Kastelein, Albert Wiegman, Daniel Gaudet Lancet - cardiovascular
  After 80 weeks of treatment, evolocumab was safe, well tolerated, and led to sustained reductions in LDL cholesterol in paediatric patients with heterozygous familial hypercholesterolaemia. When lipid goals cannot be achieved with conventional treatments, evolocumab is an effective add-on (...) (The Lancet Diabetes & Endocrinology 10, 10 (2022))

1 September

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Articles] Efficacy of telemedicine for the management of cardiovascular disease: a systematic review and meta-analysis - Pei Xuan Kuan, Weng Ken Chan, Denisa Khoo Fern Ying, Mohd Aizuddin Abdul Rahman, Kalaiarasu M Peariasamy, Nai Ming Lai, Nicholas L Mills, Atul Anand Lancet - cardiovascular
  Telemedicine including both remote disease monitoring and consultation might reduce short-term cardiovascular-related hospitalisation and mortality risk among patients with heart failure. Future research should evaluate the sustained effects of telemedicine (...) (The Lancet Digital Health 4, 9 (2022))

29 August

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 14:00
  [Articles] Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials - Cholesterol Treatment Trialists' Collaboration Lancet - cardiovascular
  Statin therapy caused a small excess of mostly mild muscle pain. Most (>90%) of all reports of muscle symptoms by participants allocated statin therapy were not due to the statin. The small risks of muscle symptoms are much lower than the known cardiovascular benefits. There is a need to (...) (The Lancet 400, 10355 (2022))
• 12:00
  [Articles] Sex-specific evaluation and redevelopment of the GRACE score in non-ST-segment elevation acute coronary syndromes in populations from the UK and Switzerland: a multinational analysis with external cohort validation - Florian A Wenzl, Simon Kraler, Gareth Ambler, Clive Weston, Sereina A Herzog, Lorenz Räber, Olivier Muller, Giovanni G Camici, Marco Roffi, Hans Rickli, Keith A A Fox, Mark de Belder, Dragana Radovanovic, John Deanfield, Thomas F Lüscher Lancet - cardiovascular
  The GRACE 2.0 score has limited discriminatory performance and underestimates in-hospital mortality in female patients with NSTE-ACS. The GRACE 3.0 score performs better in men and women and reduces sex inequalities in risk stratification. (The Lancet 400, 10354 (2022))

27 August

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 17:05
  [Articles] Autoimmune diseases and cardiovascular risk: a population-based study on 19 autoimmune diseases and 12 cardiovascular diseases in 22 million individuals in the UK - Nathalie Conrad, Geert Verbeke, Geert Molenberghs, Laura Goetschalckx, Thomas Callender, Geraldine Cambridge, Justin C Mason, Kazem Rahimi, John J V McMurray, Jan Y Verbakel Lancet - cardiovascular
  These findings warrant targeted cardiovascular prevention measures, in particular in younger patients with autoimmune diseases, and further research into pathophysiological mechanisms underlying these complications. (The Lancet 400, 10354 (2022))
• 00:30
  [Articles] Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19 - Christos P Kotanidis, Cheng Xie, Donna Alexander, Jonathan C L Rodrigues, Katie Burnham, Alexander Mentzer, Daniel O’Connor, Julian Knight, Muhammad Siddique, Helen Lockstone, Sheena Thomas, Rafail Kotronias, Evangelos K Oikonomou, Ileana Badi, Maria Lyasheva, Cheerag Shirodaria, Sheila F Lumley, Bede Constantinides, Nicholas Sanderson, Gillian Rodger, Kevin K Chau, Archie Lodge, Maria Tsakok, Fergus Gleeson, David Adlam, Praveen Rao, Das Indrajeet, Aparna Deshpande, Amrita Bajaj, Benjamin J Hudson, Vivek Srivastava, Shakil Farid, George Krasopoulos, Rana Sayeed, Ling-Pei Ho, Stefan (...) Lancet - cardiovascular
  Radiotranscriptomic analysis of CT angiography scans introduces a potentially powerful new platform for the development of non-invasive imaging biomarkers. Application of this platform in routine CT pulmonary angiography scans done in patients with COVID-19 produced the radiotranscriptomic (...) (The Lancet Digital Health 4, 10 (2022))

23 August

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Clinical Picture] Livedo reticularis - Soumya Chatterjee Lancet - cardiovascular
  A 32-year-old woman with a long history of Raynaud's phenomenon presented to the rheumatology clinic for assessment of severe fatigue and a mottled, purplish discolouration of the skin of her lower extremities. In 2014, she was diagnosed with chronic idiopathic dysautonomia, which leads to (...) (The Lancet Rheumatology (2022))

20 August

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Clinical Picture] A heart of iron: juvenile haemochromatosis presents with cardiac failure - Iside Cartella, Giovanni A Tavecchia, Giuseppina Quattrocchi, Cristina Giannattasio, Elisabetta Volpato, Matteo Palazzini, Andrea Garascia, Manlio Cipriani, Maria Frigerio, Enrico Ammirati, Patrizia Pedrotti Lancet - cardiovascular
  A 39-year-old man was transferred to our centre for investigation of advanced heart failure with severe biventricular dilation and dysfunction. The patient had been admitted 10 days earlier reporting dyspnoea. (The Lancet 400, 10352 (2022))

13 August

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:13
  [Review] Cardiorenal protection of SGLT2 inhibitors—Perspectives from metabolic reprogramming - Yue-Ming Gao, Song-Tao Feng, Yi Wen, Tao-Tao Tang, Bin Wang, Bi-Cheng Liu Lancet - cardiovascular
  Sodium-glucose co-transporter 2 (SGLT2) inhibitors, initially developed as a novel class of anti-hyperglycaemic drugs, have been shown to significantly improve metabolic indicators and protect the kidneys and heart of patients with or without type 2 diabetes mellitus. The possible mechanisms (...) (eBioMedicine 83, (2022))
• 00:00
  [Clinical Picture] No clubbing in the fingers, only in the toes: patent ductus arteriosus and reversed shunting - Vijayan Ganesan, Viswanantha Kartik, Ajay Alex Lancet - cardiovascular
  A 26-year-old man with an 8-year history of breathlessness on exertion was referred to our hospital for assessment. Previously, he had been noted to have clubbing of his toes and a heart murmur. (The Lancet 400, 10351 (2022))

10 August

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:14
  [Articles] Low temperature and temperature decline increase acute aortic dissection risk and burden: A nationwide case crossover analysis at hourly level among 40,270 patients - Qingli Zhang, Li Peng, Jialu Hu, Huichu Li, Yixuan Jiang, Weiyi Fang, Hongbing Yan, Jiyan Chen, Weimin Wang, Dingcheng Xiang, Xi Su, Bo Yu, Yan Wang, Yawei Xu, Lefeng Wang, Chunjie Li, Yundai Chen, Dong Zhao, Wenzhen Ge, Michelle L. Bell, Antonio Gasparrini, Junbo Ge, Yong Huo, Haidong Kan Lancet - cardiovascular
  This is the largest nationwide study demonstrating robust associations of low temperature and temperature decline with AAD onset. We, for the first time, calculated the corresponding disease burden and further showed that central heating may be a modifier for temperature-related AAD risk and (...) (The Lancet Regional Health – Western Pacific 28, (2022))

9 August

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:12
  [Articles] Birth weight and long-term risk of mortality among US men and women: Results from three prospective cohort studies - Yi-Xin Wang, Ming Ding, Yanping Li, Liang Wang, Janet W. Rich-Edwards, Andrea A. Florio, JoAnn E. Manson, Jorge E. Chavarro Lancet - cardiovascular
  low birth weight was associated with a greater risk of cardiovascular and respiratory disease mortality among women, while large birth weight was associated with a greater cancer mortality risk in both men and women. (The Lancet Regional Health – Americas 15, (2022))

5 August

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:15
  [Articles] Ethnic disparities in out-of-hospital cardiac arrest: A population-based cohort study among adult Danish immigrants - Rodrigue Garcia, Deepthi Rajan, Peder Emil Warming, Jesper Svane, Christoffer Vissing, Peter Weeke, Carlo Alberto Barcella, Reza Jabbari, Gunnar Hilmar Gislason, Christian Torp-Pedersen, Jørgen Holm Petersen, Fredrik Folke, Jacob Tfelt-Hansen Lancet - cardiovascular
  This study emphasizes that ethnicity is associated with OHCA risk, even when considering traditional cardiac arrest risk factors. (The Lancet Regional Health – Europe 22, (2022))

3 August

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:14
  [Articles] Association of the depressive scores, depressive symptoms, and conversion patterns of depressive symptoms with the risk of new-onset chronic diseases and multimorbidity in the middle-aged and elderly Chinese population - Yaoling Wang, Gege Jiang, Liping Wang, Minfang Chen, Kang Yang, Kai Wen, Yujie Lan, Niuniu Hou, Wei Li Lancet - cardiovascular
  DS is closely associated with new-onset risk of chronic diseases and multimorbidity, and awareness of the risk associated with pre-DS status (6 (eClinicalMedicine 52, (2022))
• 19:13
  [Articles] Quantitative stiffness assessment of cardiac grafts using ultrasound in a porcine model: A tissue biomarker for heart transplantation - Olivier Pedreira, Clement Papadacci, Lionel Augeul, Joseph Loufouat, Mégane Lo-Grasso, Mickael Tanter, René Ferrera, Mathieu Pernot Lancet - cardiovascular
  Myocardial stiffness increase was quantified as a function of preservation time and harvesting conditions. The correlation between SWV and cardiac function index suggests that SWV could be used as a marker of graft viability. This technique may be transposed to clinical transplantation for (...) (eBioMedicine 83, (2022))

2 August

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] Balloon pulmonary angioplasty versus riociguat in inoperable chronic thromboembolic pulmonary hypertension (MR BPA): an open-label, randomised controlled trial - Takashi Kawakami, Hiromi Matsubara, Toshiro Shinke, Kohtaro Abe, Shun Kohsaka, Kazuya Hosokawa, Yu Taniguchi, Hiroto Shimokawahara, Yoshitake Yamada, Masaharu Kataoka, Aiko Ogawa, Mitsushige Murata, Masahiro Jinzaki, Kenichi Hirata, Hiroyuki Tsutsui, Yasunori Sato, Keiichi Fukuda Lancet - cardiovascular
  Compared with riociguat, BPA was associated with a greater improvement in mean pulmonary arterial pressure in patients with inoperable CTEPH at 12 months, although procedure-related complications were reported. These findings support BPA as a reasonable option for inoperable CTEPH in centres (...) (The Lancet Respiratory Medicine 10, 10 (2022))
• 00:30
  [Articles] Healthy lifestyle and life expectancy at age 30 years in the Chinese population: an observational study - Qiufen Sun, Dongmei Yu, Junning Fan, Canqing Yu, Yu Guo, Pei Pei, Ling Yang, Yiping Chen, Huaidong Du, Xiaoming Yang, Sam Sansome, Yongming Wang, Wenhua Zhao, Junshi Chen, Zhengming Chen, Liyun Zhao, Jun Lv, Liming Li, China Kadoorie Biobank Collaborative Group Lancet - cardiovascular
  Our findings suggest that increasing the adoption of these five healthy lifestyle factors through public health interventions could be associated with substantial gains in life expectancy in the Chinese population. (The Lancet Public Health 7, 12 (2022))

23 July

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Comment] Blood pressure control according to type 2 diabetes status - Luis M Ruilope, Gema Ruiz-Hurtado Lancet - cardiovascular
  The control of arterial hypertension is mandatory in people with and without type 2 diabetes. The Article by the Blood Pressure Lowering Treatment Trialists' Collaboration (BPLTTC), published in The Lancet Diabetes & Endocrinology.1 One-stage individual participant-level data meta-analysis (...) (The Lancet Diabetes & Endocrinology 10, 9 (2022))
• 00:30
  [Articles] Blood pressure-lowering treatment for prevention of major cardiovascular diseases in people with and without type 2 diabetes: an individual participant-level data meta-analysis - Milad Nazarzadeh, Zeinab Bidel, Dexter Canoy, Emma Copland, Derrick A Bennett, Abbas Dehghan, George Davey Smith, Rury R Holman, Mark Woodward, Ajay Gupta, Amanda I Adler, Malgorzata Wamil, Naveed Sattar, William C Cushman, Richard J McManus, Koon Teo, Barry R Davis, John Chalmers, Carl J Pepine, Kazem Rahimi, Blood Pressure Lowering Treatment Trialists' Collaboration Lancet - cardiovascular
  Although the relative beneficial effects of blood pressure reduction on major cardiovascular events were weaker in participants with type 2 diabetes than in those without, absolute effects were similar. The difference in relative risk reduction was not related to the baseline blood pressure or (...) (The Lancet Diabetes & Endocrinology 10, 9 (2022))

22 July

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:13
  [Articles] Risk factors, mortality trends, and cardiovascular diseases in people with Type 1 diabetes and controls in Sweden: An observational cohort study - Sara Hallström, Magnus Olof Wijkman, Johnny Ludvigsson, Per Ekman, Marc Alan Pfeffer, Hans Wedel, Annika Rosengren, Marcus Lind Lancet - cardiovascular
  Excess mortality persisted over time in persons with T1D, largely in patients with cardiorenal complications. Improved secondary prevention with a focus on individualized treatment is needed to close the gap in mortality for individuals with (...) (The Lancet Regional Health – Europe 21, (2022))

16 July

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 01:36
  [Articles] Circulating cardiac biomarkers improve risk stratification for incident cardiovascular disease in community dwelling populations - Zhenqiang Wu, Anna P. Pilbrow, Oi Wah Liew, Jenny P.C. Chong, John Sluyter, Lynley K. Lewis, Moritz Lassé, Chris M. Frampton, Rod Jackson, Katrina Poppe, Carlos Arturo Camargo, Vicky A. Cameron, Robert Scragg, A. Mark Richards Lancet - cardiovascular
  Increments in plasma cardiac biomarkers robustly and reproducibly predicted increased hazard of incident CVD, independent of established risk factors, in two community-dwelling populations. Cardiac markers may augment risk assessment for onset of CVD in primary (...) (eBioMedicine 82, (2022))
• 01:35
  [Articles] Associations of birth weight and later life lifestyle factors with risk of cardiovascular disease in the USA: A prospective cohort study - Yi-Xin Wang, Yanping Li, Janet W. Rich-Edwards, Andrea A. Florio, Zhilei Shan, Siwen Wang, JoAnn E. Manson, Kenneth J. Mukamal, Eric B. Rimm, Jorge E. Chavarro Lancet - cardiovascular
  Lower birth weight may interact synergistically with unhealthy lifestyle factors in adulthood to further increase the risk of CHD among women. (eClinicalMedicine 51, (2022))
• 00:30
  [Articles] Contributions of event rates, pre-hospital deaths, and deaths following hospitalisation to variations in myocardial infarction mortality in 326 districts in England: a spatial analysis of linked hospitalisation and mortality data - Perviz Asaria, James E Bennett, Paul Elliott, Theo Rashid, Hima Iyathooray Daby, Margaret Douglass, Darrel P Francis, Daniela Fecht, Majid Ezzati Lancet - cardiovascular
  Most of the variation in myocardial infarction mortality in England is due to variation in myocardial infarction event rate, with a smaller role for case fatality. Most variation in case fatality occurs before rather than after hospital admission. Reducing subnational variations in myocardial (...) (The Lancet Public Health (2022))

8 July

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:13
  [Articles] Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies - Susanna C. Larsson, Stephen Burgess Lancet - cardiovascular
  This study found robust evidence that cigarette smoking causes a wide range of diseases. (eBioMedicine 82, (2022))

7 July

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:28
  [Articles] Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction - Cong Lan, Caiyu Chen, Shuang Qu, Nian Cao, Hao Luo, Cheng Yu, Na Wang, Yuanzheng Xue, Xuewei Xia, Chao Fan, Hongmei Ren, Yongjian Yang, Pedro A. Jose, Zaicheng Xu, Gengze Wu, Chunyu Zeng Lancet - cardiovascular
  Our results reveal a significant role of DYRK1A in cardiac repair and suggest a drug target with translational potential for treating cardiomyopathy. (eBioMedicine 82, (2022))

5 July

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:14
  [Articles] Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis - Yingchun Luo, Yun Zhang, Xuejie Han, Yue Yuan, Yun Zhou, Yunlong Gao, Hui Yu, Jiawei Zhang, Yiya Shi, Yu Duan, Xinbo Zhao, Sen Yan, Hongting Hao, Chenguang Dai, Shiqi Zhao, Jing Shi, Wenpeng Li, Song Zhang, Wei Xu, Ning Fang, Yongtai Gong, Yue Li Lancet - cardiovascular
  Our findings revealed a novel causal role of aberrant gut microbiota and metabolites in pathogenesis of cold-related AF, which raises the possibility of selectively targeting microbiota and microbial metabolites as a potential therapeutic strategy for cold-related (...) (eBioMedicine 82, (2022))

1 July

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:13
  [Articles] Trends in characteristics of the recipients of new prescription stimulants between years 2010 and 2020 in the United States: An observational cohort study - Shannon Brumbaugh, Wen Jan Tuan, Alyssa Scott, James R. Latronica, Curtis Bone Lancet - cardiovascular
  Prescription stimulant dispensing may have liberalized during the study period in some demographics as a greater number of new prescriptions were dispensed to individuals with risk of adverse outcomes (i.e. older individuals, obese individuals, and geriatric patients with CV risk factors) (...) (eClinicalMedicine 50, (2022))
• 00:00
  [Review] 2022 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer, including patients with COVID-19 - Dominique Farge, Corinne Frere, Jean M Connors, Alok A Khorana, Ajay Kakkar, Cihan Ay, Andres Muñoz, Benjamin Brenner, Pedro H Prata, Dialina Brilhante, Darko Antic, Patricia Casais, María Cecilia Guillermo Esposito, Takayuki Ikezoe, Syed A Abutalib, Luis A Meillon-García, Henri Bounameaux, Ingrid Pabinger, James Douketis, International Initiative on Thrombosis and Cancer (ITAC) advisory panel Lancet - cardiovascular
  The International Initiative on Thrombosis and Cancer is an independent academic working group of experts aimed at establishing global consensus for the treatment and prophylaxis of cancer-associated thrombosis. The 2013, 2016, and 2019 International Initiative on Thrombosis and Cancer clinical (...) (The Lancet Oncology 23, 7 (2022))

27 June

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 01:00
  [Articles] Abdominal aortic calcification on lateral spine images captured during bone density testing and late-life dementia risk in older women: A prospective cohort study - Tenielle Porter, Marc Sim, Richard L. Prince, John T. Schousboe, Catherine Bondonno, Wai H. Lim, Kun Zhu, Douglas P. Kiel, Jonathan M. Hodgson, Simon M. Laws, Joshua R. Lewis Lancet - cardiovascular
  In community-dwelling older women, those with more advanced AAC had higher risk of late-life dementia, independent of cardiovascular risk factors and APOE genotype. Given the widespread use of bone density testing, simultaneously capturing AAC information may be a novel, non-invasive, scalable (...) (The Lancet Regional Health – Western Pacific 26, (2022))
• 19:17
  [Review] Myocardial regeneration protocols towards the routine clinical scenario: An unseemly path from bench to bedside - Nadia Salerno, Luca Salerno, Fabiola Marino, Mariangela Scalise, Antonio Chiefalo, Giuseppe Panuccio, Antonella De Angelis, Eleonora Cianflone, Konrad Urbanek, Daniele Torella Lancet - cardiovascular
  Heart failure secondary to cardiomyocyte loss and/or dysfunction is the number one killer worldwide. The field of myocardial regeneration with its far-reaching primary goal of cardiac remuscularization and its hard-to-accomplish translation from bench to bedside, has been filled with ups and (...) (eClinicalMedicine 50, (2022))

22 June

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:14
  [Articles] Targeting miR-30d reverses pathological cardiac hypertrophy - Jin Li, Zhao Sha, Xiaolan Zhu, Wanru Xu, Weilin Yuan, Tingting Yang, Bing Jin, Yuwei Yan, Rui Chen, Siqi Wang, Jianhua Yao, Jiahong Xu, Zitong Wang, Guoping Li, Saumya Das, Liming Yang, Junjie Xiao Lancet - cardiovascular
  Overexpression of miR-30d may be a potential approach to treat pathological cardiac hypertrophy. (eBioMedicine 81, (2022))

4 June

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:13
  [Articles] Assessment of U.S. heart transplantation equity as a function of race: Observational analyses of the OPTN database - Rebecca Cogswell, Maria Masotti, Alanna A. Morris, Allyson Hart, Tom Murray, Clyde Yancy Lancet - cardiovascular
  Both the measured rate of transplantation and rate of delisting for death or clinical deterioration have worsened for Black compared to White waitlist candidates under the new allocation system. Causes for these disparities require further (...) (The Lancet Regional Health – Americas 13, (2022))

30 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:13
  [Articles] Biomarker-based risk model to predict cardiovascular events in patients with acute coronary syndromes – Results from BIPass registry - Jiali Wang, Wei Gao, Guanghui Chen, Ming Chen, Zhi Wan, Wen Zheng, Jingjing Ma, Jiaojiao Pang, Guangmei Wang, Shuo Wu, Shuo Wang, Feng Xu, Derek P. Chew, Yuguo Chen, BIPass investigators Lancet - cardiovascular
  The BIPass risk model, integrating clinical variables and NT-proBNP, is useful for predicting 12-month MACE in ACS. It effectively identifies a gradient risk of cardiovascular events to aid personalized care. (The Lancet Regional Health – Western Pacific 25, (2022))

29 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:13
  [Articles] Risk of cancer in young and older patients with congenital heart disease and the excess risk of cancer by syndromes, organ transplantation and cardiac surgery: Swedish health registry study (1930–2017) - Christina Karazisi, Mikael Dellborg, Karin Mellgren, Kok Wai Giang, Kristofer Skoglund, Peter Eriksson, Zacharias Mandalenakis Lancet - cardiovascular
  The cancer risk in patients with CHD was 23% higher than in matched controls without CHD. The highest risk was found in children and in the latest birth cohort (1990–2017). (The Lancet Regional Health – Europe 18, (2022))

28 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:12
  [Articles] Gender gap in annual preventive care services in France - Bamba Gaye, Hélène Hergault, Camille Lassale, Magalie Ladouceur, Eugenie Valentin, Maxime Vignac, Nicolas Danchin, Mor Diaw, Marina Kvaskoff, Sarah Chamieh, Frederique Thomas, Erin D. Michos, Xavier Jouven Lancet - cardiovascular
  In this community-based sample, compared with men, women's participation to annual preventive care services was lower, and screened women had a lower mortality gain. Despite the demonstrated benefit of annual check-ups on health, there is a gender gap in adherence to preventive programs and in (...) (eClinicalMedicine 49, (2022))

27 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:14
  [Articles] Clinical presentation and short-term outcomes of multisystemic inflammatory syndrome in children in Lagos, Nigeria during the COVID-19 pandemic: A case series - Ogochukwu Sokunbi, Yeside Akinbolagbe, Patricia Akintan, Gabriel Oyeleke, Olusola Kusimo, Uchenna Owowo, Eyitayo Olonade, Olajide Ojo, Esieza Ikhazobor, Oluwatosin Amund, Eucharia Ogbuokiri, Mercy Funsho-Adebayo, Oluwatoyin Adeniyi, Chinyere Uzodimma, Moriam Lamina, Adeola Animashaun, Babayemi Osinaike, Ekanem Ekure, Christy Okoromah Lancet - cardiovascular
  MIS-C is an important diagnosis in children presenting with prolonged fever during the COVID-19 pandemic. Cardiovascular manifestations occurred in several children with MIS-C and improved by 6 months follow up. Early diagnosis and prompt institution of a combination of antiplatelet therapy, (...) (eClinicalMedicine 49, (2022))
• 19:13
  [Articles] Patient-derived microphysiological model identifies the therapeutic potential of metformin for thoracic aortic aneurysm - Wenrui Ma, Jingjing Zhang, Shaowen Liu, Shiqiang Yan, Kehua Xu, Yu Shrike Zhang, Mieradilijiang Abudupataer, Yang Ming, Shichao Zhu, Bitao Xiang, Xiaonan Zhou, Shaman Luo, Hui Huang, Yuyi Tang, Shan Zhang, Zhuxin Xie, Nan Chen, Xiaoning Sun, Jun Li, Hao Lai, Chunsheng Wang, Kai Zhu, Weijia Zhang Lancet - cardiovascular
  These findings support the application of this human-relevant microphysiological model in studying personalized disease characteristics and facilitating drug discovery for TAA. Metformin may regulate contractile phenotypes and metabolic dysfunctions in diseased HAoSMCs and limit aortic (...) (eBioMedicine 81, (2022))
• 07:15
  [Articles] Cardiovascular effects of intensive lifestyle intervention in adults with overweight/obesity and type 2 diabetes according to body weight time in range - Menghui Liu, Rihua Huang, Lin Xu, Shaozhao Zhang, Xiangbin Zhong, Xiaohong Chen, Yifen Lin, Zhenyu Xiong, Lichun Wang, Xinxue Liao, Xiaodong Zhuang Lancet - cardiovascular
  In adults with overweight/obesity and type 2 diabetes, ILI might help in lowering the risk of cardiovascular events when the lower body weight is maintained after weight loss. (eClinicalMedicine 49, (2022))

20 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] Clinical assessment as a part of an early warning score—a Danish cluster-randomised, multicentre study of an individual early warning score - Pernille B Nielsen, Caroline S Langkjær, Martin Schultz, Anne Marie Kodal, Niels Egholm Pedersen, John Asger Petersen, Theis Lange, Michael Dan Arvig, Christian S Meyhoff, Morten H Bestle, Bibi Hølge-Hazelton, Gitte Bunkenborg, Anne Lippert, Ove Andersen, Lars Simon Rasmussen, Kasper Karmark Iversen Lancet - cardiovascular
  Including clinical assessment in I-EWS was feasible and overall non-inferior to the widely implemented NEWS in terms of all-cause mortality at 30 days, and the number of routine measurements was minimally reduced. However I-EWS should be used with caution in surgical (...) (The Lancet Digital Health 4, 7 (2022))

14 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Clinical Picture] Acute onset of fever, eosinophilia, rash, acute kidney injury, and a positive Monospot test in a patient on lamotrigine: DRESS syndrome - Mahmoud Abdelnabi, Marawan Elmssary, Jasmine Sekhon, Juthipong Benjanuwattra Lancet - cardiovascular
  A 20-year-old daycare teacher presented to our hospital reporting a generalised erythematous maculopapular rash. The patient also had a fever, myalgia, nausea, reduced urine output, peripheral oedema, and dyspnoea on exertion. She reported that the rash had rapidly increased in size over the (...) (The Lancet 399, 10338 (2022))

13 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:13
  [Articles] The heart-brain axis: A proteomics study of meditation on the cardiovascular system of Tibetan Monks - Ting Xue, Benjamin Chiao, Tianjiao Xu, Han Li, Kai Shi, Ying Cheng, Yuan Shi, Xiaoli Guo, Shanbao Tong, Menglin Guo, Soo Hong Chew, Richard P. Ebstein, Donghong Cui Lancet - cardiovascular
  To our knowledge, this work is the first well-controlled proteomics investigation of long-term meditation, which opens up a window for individuals characterized by a sedentary lifestyle to improve their cardiovascular health with an accessible method practised for more than two (...) (eBioMedicine 80, (2022))

12 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 21:52
  [Articles] Association of gamma-glutamyltransferase levels with total mortality, liver-related and cardiovascular outcomes: A prospective cohort study in the UK Biobank - Frederick K Ho, Lyn D Ferguson, Carlos A Celis-Morales, Stuart R Gray, Ewan Forrest, William Alazawi, Jason MR Gill, Srinivasa Vittal Katikireddi, John GF Cleland, Paul Welsh, Jill P Pell, Naveed Sattar Lancet - cardiovascular
  Our study suggests that a modest elevation in GGT levels should trigger a discussion with the individual to review diet and lifestyle including alcohol intake and consideration of formal liver disease and CV risk assessment if not previously (...) (eClinicalMedicine 48, (2022))

10 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:13
  [Comment] Intersectionality and genetic ancestry: New methods to solve old problems - Carlos D. Vera, McKay Mullen, Navjot Minhas, Joseph C. Wu Lancet - cardiovascular
  Racial divisiveness is a known contributing factor to negative health outcomes such as increased chronic disease among minority populations. We need innovative studies to bridge these diversity gaps in health and a paradigm shift in our approaches. Certainly, there is strong motivation to close (...) (eBioMedicine 80, (2022))

5 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 12:30
  [Series] Menopause: a cardiometabolic transition - Rossella E Nappi, Peter Chedraui, Irene Lambrinoudaki, Tommaso Simoncini Lancet - cardiovascular
  Menopause is often a turning point for women's health worldwide. Increasing knowledge from experimental data and clinical studies indicates that cardiometabolic changes can manifest at the menopausal transition, superimposing the effect of ageing onto the risk of cardiovascular disease. The (...) (The Lancet Diabetes & Endocrinology 10, 6 (2022))

3 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:16
  [Articles] Epidemiology, management, and outcomes of atrial fibrillation among 30 million citizens in Shanghai, China from 2015 to 2020: A medical insurance database study - Mu Chen, Cheng Li, Peng Liao, Xin Cui, Wenqi Tian, Qunshan Wang, Jian Sun, Mei Yang, Li Luo, Hong Wu, Yi-Gang Li Lancet - cardiovascular
  The burdens of AF and AF-related outcomes in Shanghai are high. Management of AF is markedly improved in recent years, and was not or only slightly impeded by the COVID-19 pandemic. There are sex differences in the prevalence, management, and outcomes of (...) (The Lancet Regional Health – Western Pacific 23, (2022))
• 19:16
  [Articles] Aortic arch calcification and risk of all-cause mortality and cardiovascular disease: The Guangzhou Biobank Cohort Study - Wen Bo Tian, Wei Sen Zhang, Chao Qiang Jiang, Xiang Yi Liu, Ya Li Jin, Tai Hing Lam, Kar Keung Cheng, Lin Xu Lancet - cardiovascular
  As chest X-ray has been performed commonly for health screening and in hospital patients when first admitted, AAC measured by chest X-ray can be further applied to assist cardiovascular risk stratification in the community and clinical (...) (The Lancet Regional Health – Western Pacific 23, (2022))

30 April

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] A village doctor-led multifaceted intervention for blood pressure control in rural China: an open, cluster randomised trial - Yingxian Sun, Jianjun Mu, Dao Wen Wang, Nanxiang Ouyang, Liying Xing, Xiaofan Guo, Chunxia Zhao, Guocheng Ren, Ning Ye, Ying Zhou, Jun Wang, Zhao Li, Guozhe Sun, Ruihai Yang, Chung-Shiuan Chen, Jiang He, CRHCP Study Group Lancet - cardiovascular
  Compared with enhanced usual care, village doctor-led intervention resulted in statistically significant improvements in blood pressure control among rural residents in China. This feasible, effective, and sustainable implementation strategy could be scaled up in rural China and other (...) (The Lancet 399, 10339 (2022))

14 April

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 06:41
  [Correspondence] Cerebral venous thrombosis after COVID-19 vaccines: Do we know the mechanism? - Cesare de Gregorio, Giuseppe Calcaterra, Nicholas G. Kounis, Pier Paolo Bassareo, Jawahar L. Mehta Lancet - cardiovascular
  The Covid-19 pandemic has affected the world community for over 2 years. Since December 2020, most countries started with Covid-19 vaccination programmes using messenger RNA (BNT162b2 and mRNA-1273/CX-024414) and adenovirus vector (ChAdOx1nCoV-19 and JNJ-78436735) vaccines, with an (...) (The Lancet Regional Health – Europe 16, (2022))

12 April

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] Myopericarditis following COVID-19 vaccination and non-COVID-19 vaccination: a systematic review and meta-analysis - Ryan Ruiyang Ling, Kollengode Ramanathan, Felicia Liying Tan, Bee Choo Tai, Jyoti Somani, Dale Fisher, Graeme MacLaren Lancet - cardiovascular
  The overall risk of myopericarditis after receiving a COVID-19 vaccine is low. However, younger males have an increased incidence of myopericarditis, particularly after receiving mRNA vaccines. Nevertheless, the risks of such rare adverse events should be balanced against the risks of COVID-19 (...) (The Lancet Respiratory Medicine 10, 7 (2022))

11 April

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 18:42
  [Articles] Prevalence and risk of atrial fibrillation in China: A national cross-sectional epidemiological study - Shaobo Shi, Yanhong Tang, Qingyan Zhao, Hong Yan, Bin Yu, Qiangsun Zheng, Yigang Li, Liangrong Zheng, Yiqiang Yuan, Jingquan Zhong, Jian Xu, Yanqing Wu, Jing Xu, Lin Chen, Shufeng Li, Jian Jiang, Jingfeng Wang, Jie Fan, Minglong Chen, Baopeng Tang, Wei Li, Qiang Wu, Bei Shi, Shenghua Zhou, Xingsheng Zhao, Yuehui Yin, Zheng Zhang, Guoqiang Zhong, Xuebin Han, Fan Liu, Ming Wu, Lianjun Gao, Bo Yang, He Huang, Congxin Huang, China Atrial Fibrillation Center Project (...) Lancet - cardiovascular
  The prevalence of AF was 1.6% in the Chinese adult population and increased with age, with significant geographic variation. Older age, male sex, and cardiovascular disease were potent factors associated with AF. It is crucial to increase the awareness of AF and disseminate standardized (...) (The Lancet Regional Health – Western Pacific 23, (2022))

4 April

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 14:30
  [Articles] Aggressive intraoperative warming versus routine thermal management during non-cardiac surgery (PROTECT): a multicentre, parallel group, superiority trial - Daniel I Sessler, Lijian Pei, Kai Li, Shusen Cui, Matthew T V Chan, Yuguang Huang, Jingxiang Wu, Xuemei He, Gausan R Bajracharya, Eva Rivas, Carmen K M Lam, PROTECT Investigators Lancet - cardiovascular
  The incidence of a 30-day composite of major cardiovascular outcomes did not differ significantly in patients randomised to 35·5°C and to 37°C. At least over a 1·5°C range from very mild hypothermia to full normothermia, there was no evidence that any substantive outcome varied. Keeping core (...) (The Lancet 399, 10337 (2022))

2 April

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] Metabolic risk factors and effect of alirocumab on cardiovascular events after acute coronary syndrome: a post-hoc analysis of the ODYSSEY OUTCOMES randomised controlled trial - Petr Ostadal, Philippe Gabriel Steg, Yann Poulouin, Deepak L Bhatt, Vera A Bittner, Terrence Chua, Rafael Diaz, Shaun G Goodman, Yong Huo, Johan Wouter Jukema, Yuri Karpov, Robert Pordy, Michel Scemama, Michael Szarek, Harvey D White, Gregory G Schwartz, ODYSSEY OUTCOMES Investigators Lancet - cardiovascular
  Accumulation of metabolic risk factors was associated with higher risk of MACE in patients with recent acute coronary syndrome. Alirocumab reduced MACE consistently, but aRR increased with number of metabolic risk factors. (The Lancet Diabetes & Endocrinology 10, 5 (2022))

21 March

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:12
  [Articles] Body mass index in adolescence, risk of type 2 diabetes and associated complications: A nationwide cohort study of men - Andréasson Karin, Edqvist Jon, Adiels Martin, Björck Lena, Lindgren Martin, Sattar Naveed, Lind Marcus, Åberg Maria, Rosengren Annika Lancet - cardiovascular
  Rising adolescent BMI was associated with increased risk of type 2 diabetes diagnosed at a younger age, with poorer metabolic control, and a greater prevalence of albuminuria, all suggestive of worse prognosis. (eClinicalMedicine 46, (2022))

16 March

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 14:44
  [Articles] Regional variations in the process of care for patients undergoing percutaneous coronary intervention in Japan - Satoshi Shoji, Kyohei Yamaji, Alexander T. Sandhu, Nobuhiro Ikemura, Yasuyuki Shiraishi, Taku Inohara, Paul A. Heidenreich, Tetsuya Amano, Yuji Ikari, Shun Kohsaka Lancet - cardiovascular
  Measuring the quality of care has been central for improving the outcomes of patients undergoing percutaneous coronary intervention (PCI). This study described the performance rates and regional variations in quality metrics for PCI using a representative national Japanese (...) (The Lancet Regional Health – Western Pacific 22, (2022))

6 March

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:16
  [Articles] Cardiovascular health and healthy longevity in people with and without cardiometabolic disease: A prospective cohort study - Chenjie Xu, Pengjie Zhang, Zhi Cao Lancet - cardiovascular
  An ideal CVH is associated with a lower risk of premature mortality and longer life expectancy whether in general population or CMD patients. Our study highlights the benefits of maintaining better CVH across the life course and calls attention to the need for comprehensive strategies (healthy (...) (eClinicalMedicine 45, (2022))

4 March

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:12
  [Health Policy] 2021 World Health Organization guideline on pharmacological treatment of hypertension: Policy implications for the region of the Americas - Norm R.C. Campbell, Melanie Paccot Burnens, Paul K. Whelton, Sonia Y. Angell, Marc G. Jaffe, Jennifer Cohn, Alfredo Espinosa Brito, Vilma Irazola, Jeffrey W. Brettler, Edward J. Roccella, Javier Isaac Maldonado Figueredo, Andres Rosende, Pedro Ordunez Lancet - cardiovascular
  Cardiovascular disease (CVD) is the leading cause of death in the Americas and raised blood pressure accounts for over 50% of CVD. In the Americas over a quarter of adult women and four in ten adult men have hypertension and the diagnosis, treatment and control are suboptimal. In 2021, the (...) (The Lancet Regional Health – Americas 9, (2022))

1 March

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Articles] Use of statins for the prevention of cardiovascular disease in 41 low-income and middle-income countries: a cross-sectional study of nationally representative, individual-level data - Maja E Marcus, Jennifer Manne-Goehler, Michaela Theilmann, Farshad Farzadfar, Sahar Saeedi Moghaddam, Mohammad Keykhaei, Amirali Hajebi, Scott Tschida, Julia M Lemp, Krishna K Aryal, Matthew Dunn, Corine Houehanou, Silver Bahendeka, Peter Rohloff, Rifat Atun, Till W Bärnighausen, Pascal Geldsetzer, Manuel Ramirez-Zea, Vineet Chopra, Michele Heisler, Justine I Davies, Mark D Huffman, Sebastian Vollmer, David Flood Lancet - cardiovascular
  In a diverse sample of LMICs, statins are used by about one in ten eligible people for the primary prevention of cardiovascular diseases and one in five eligible people for secondary prevention. There is an urgent need to scale up statin use in LMICs to achieve WHO targets. Policies and (...) (The Lancet Global Health 10, 3 (2022))

12 February

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Clinical Picture] Under-sensing by a temporary pacemaker after cardiac surgery and ventricular fibrillation - Konstantinos C Theodoropoulos, Alexandra Liakopoulou, Sokratis Tsagkaropoulos, George Kassimis, Polychronis Antonitsis, Kyriakos Anastasiadis Lancet - cardiovascular
  An 80-year-old man with a 6-month-history of shortness of breath on minimal exertion and fatigue was admitted to our unit for a planned operation to replace his stenotic aortic valve. The surgery was uneventful and a temporary ventricular epicardial pacing lead was placed on the free wall of (...) (The Lancet 399, 10325 (2022))

11 February

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:14
  [Articles] Unbiased plasma proteomics discovery of biomarkers for improved detection of subclinical atherosclerosis - Estefanía Núñez, Valentín Fuster, María Gómez-Serrano, José Manuel Valdivielso, Juan Miguel Fernández-Alvira, Diego Martínez-López, José Manuel Rodríguez, Elena Bonzon-Kulichenko, Enrique Calvo, Alvaro Alfayate, Marcelino Bermudez-Lopez, Joan Carles Escola-Gil, Leticia Fernández-Friera, Isabel Cerro-Pardo, José María Mendiguren, Fátima Sánchez-Cabo, Javier Sanz, José María Ordovás, Luis Miguel Blanco-Colio, José Manuel García-Ruiz, Borja Ibáñez, Enrique Lara-Pezzi, Antonio Fernández-Ortiz, José Luis Martín-Ventura, Jesús (...) Lancet - cardiovascular
  Plasma levels of IGHA2, APOA and HPT are associated with subclinical atherosclerosis independently of traditional risk factors and offers potential to predict this disease. The panel could improve primary prevention strategies in areas where imaging is not (...) (eBioMedicine 76, (2022))

7 February

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 15:00
  [Articles] Clinical predictors of acute cardiac injury and normalization of troponin after hospital discharge from COVID-19 - Joyce Q. Lu, Justin Y. Lu, Weihao Wang, Yuhang Liu, Alexandra Buczek, Roman Fleysher, Wouter S. Hoogenboom, Wei Zhu, Wei Hou, Carlos J. Rodriguez, Tim Q. Duong Lancet - cardiovascular
  Persistent cardiac injury is common among COVID-19 survivors. Readily available patient data accurately predict ACI recovery post-discharge. Early identification of at-risk patients could help prevent long-term cardiovascular (...) (eBioMedicine 76, (2022))

4 February

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:14
  [Articles] The early reduction of left ventricular mass after sleeve gastrectomy depends on the fall of branched-chain amino acid circulating levels - Lidia Castagneto-Gissey, Giulia Angelini, Geltrude Mingrone, Elena Cavarretta, Leonardo Tenori, Cristina Licari, Claudio Luchinat, Anna Luise Tiepner, Nicola Basso, Stefan R. Bornstein, Deepak L. Bhatt, Giovanni Casella Lancet - cardiovascular
  After SG a prompt and sustained decrease of the LVM, epicardial fat and insulin resistance was found. Animal and in vitro studies showed that SG improves cardiac BCAA metabolism with consequent amelioration of fat oxidation and insulin signaling translating into decreased intra-myocytic fat (...) (eBioMedicine 76, (2022))

1 February

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 15:15
  [Articles] Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial - Sanjiv J Shah, Barry A Borlaug, Eugene S Chung, Donald E Cutlip, Philippe Debonnaire, Peter S Fail, Qi Gao, Gerd Hasenfuß, Rami Kahwash, David M Kaye, Sheldon E Litwin, Philipp Lurz, Joseph M Massaro, Rajeev C Mohan, Mark J Ricciardi, Scott D Solomon, Aaron L Sverdlov, Vijendra Swarup, Dirk J van Veldhuisen, Sebastian Winkler, Martin B Leon, REDUCE LAP-HF II investigators Lancet - cardiovascular
  Placement of an atrial shunt device did not reduce the total rate of heart failure events or improve health status in the overall population of patients with heart failure and ejection fraction of greater than or equal to 40%. (The Lancet 399, 10330 (2022))

28 January

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:14
  [Review] Generating 3D human cardiac constructs from pluripotent stem cells - Chang Liu, Xing Feng, Guoping Li, Priyanka Gokulnath, Junjie Xiao Lancet - cardiovascular
  Human pluripotent stem cell (hPSC) technology has offered nearly infinite opportunities to model all kinds of human diseases in vitro. Cardiomyocytes derived from hPSCs have proved to be efficient tools for cardiac disease modeling, drug screening and pathological mechanism studies. In this (...) (eBioMedicine 76, (2022))