30 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:13
  [Articles] Biomarker-based risk model to predict cardiovascular events in patients with acute coronary syndromes – Results from BIPass registry - Jiali Wang, Wei Gao, Guanghui Chen, Ming Chen, Zhi Wan, Wen Zheng, Jingjing Ma, Jiaojiao Pang, Guangmei Wang, Shuo Wu, Shuo Wang, Feng Xu, Derek P. Chew, Yuguo Chen, BIPass investigators Lancet - cardiovascular
  The BIPass risk model, integrating clinical variables and NT-proBNP, is useful for predicting 12-month MACE in ACS. It effectively identifies a gradient risk of cardiovascular events to aid personalized care. (The Lancet Regional Health – Western Pacific 25, (2022))

29 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:13
  [Articles] Risk of cancer in young and older patients with congenital heart disease and the excess risk of cancer by syndromes, organ transplantation and cardiac surgery: Swedish health registry study (1930–2017) - Christina Karazisi, Mikael Dellborg, Karin Mellgren, Kok Wai Giang, Kristofer Skoglund, Peter Eriksson, Zacharias Mandalenakis Lancet - cardiovascular
  The cancer risk in patients with CHD was 23% higher than in matched controls without CHD. The highest risk was found in children and in the latest birth cohort (1990–2017). (The Lancet Regional Health – Europe 18, (2022))

28 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:12
  [Articles] Gender gap in annual preventive care services in France - Bamba Gaye, Hélène Hergault, Camille Lassale, Magalie Ladouceur, Eugenie Valentin, Maxime Vignac, Nicolas Danchin, Mor Diaw, Marina Kvaskoff, Sarah Chamieh, Frederique Thomas, Erin D. Michos, Xavier Jouven Lancet - cardiovascular
  In this community-based sample, compared with men, women's participation to annual preventive care services was lower, and screened women had a lower mortality gain. Despite the demonstrated benefit of annual check-ups on health, there is a gender gap in adherence to preventive programs and in (...) (eClinicalMedicine 49, (2022))

27 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:14
  [Articles] Clinical presentation and short-term outcomes of multisystemic inflammatory syndrome in children in Lagos, Nigeria during the COVID-19 pandemic: A case series - Ogochukwu Sokunbi, Yeside Akinbolagbe, Patricia Akintan, Gabriel Oyeleke, Olusola Kusimo, Uchenna Owowo, Eyitayo Olonade, Olajide Ojo, Esieza Ikhazobor, Oluwatosin Amund, Eucharia Ogbuokiri, Mercy Funsho-Adebayo, Oluwatoyin Adeniyi, Chinyere Uzodimma, Moriam Lamina, Adeola Animashaun, Babayemi Osinaike, Ekanem Ekure, Christy Okoromah Lancet - cardiovascular
  MIS-C is an important diagnosis in children presenting with prolonged fever during the COVID-19 pandemic. Cardiovascular manifestations occurred in several children with MIS-C and improved by 6 months follow up. Early diagnosis and prompt institution of a combination of antiplatelet therapy, (...) (eClinicalMedicine 49, (2022))
• 19:13
  [Articles] Patient-derived microphysiological model identifies the therapeutic potential of metformin for thoracic aortic aneurysm - Wenrui Ma, Jingjing Zhang, Shaowen Liu, Shiqiang Yan, Kehua Xu, Yu Shrike Zhang, Mieradilijiang Abudupataer, Yang Ming, Shichao Zhu, Bitao Xiang, Xiaonan Zhou, Shaman Luo, Hui Huang, Yuyi Tang, Shan Zhang, Zhuxin Xie, Nan Chen, Xiaoning Sun, Jun Li, Hao Lai, Chunsheng Wang, Kai Zhu, Weijia Zhang Lancet - cardiovascular
  These findings support the application of this human-relevant microphysiological model in studying personalized disease characteristics and facilitating drug discovery for TAA. Metformin may regulate contractile phenotypes and metabolic dysfunctions in diseased HAoSMCs and limit aortic (...) (eBioMedicine 81, (2022))
• 07:15
  [Articles] Cardiovascular effects of intensive lifestyle intervention in adults with overweight/obesity and type 2 diabetes according to body weight time in range - Menghui Liu, Rihua Huang, Lin Xu, Shaozhao Zhang, Xiangbin Zhong, Xiaohong Chen, Yifen Lin, Zhenyu Xiong, Lichun Wang, Xinxue Liao, Xiaodong Zhuang Lancet - cardiovascular
  In adults with overweight/obesity and type 2 diabetes, ILI might help in lowering the risk of cardiovascular events when the lower body weight is maintained after weight loss. (eClinicalMedicine 49, (2022))

20 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] Clinical assessment as a part of an early warning score—a Danish cluster-randomised, multicentre study of an individual early warning score - Pernille B Nielsen, Caroline S Langkjær, Martin Schultz, Anne Marie Kodal, Niels Egholm Pedersen, John Asger Petersen, Theis Lange, Michael Dan Arvig, Christian S Meyhoff, Morten H Bestle, Bibi Hølge-Hazelton, Gitte Bunkenborg, Anne Lippert, Ove Andersen, Lars Simon Rasmussen, Kasper Karmark Iversen Lancet - cardiovascular
  Including clinical assessment in I-EWS was feasible and overall non-inferior to the widely implemented NEWS in terms of all-cause mortality at 30 days, and the number of routine measurements was minimally reduced. However I-EWS should be used with caution in surgical (...) (The Lancet Digital Health 4, 7 (2022))

14 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Clinical Picture] Acute onset of fever, eosinophilia, rash, acute kidney injury, and a positive Monospot test in a patient on lamotrigine: DRESS syndrome - Mahmoud Abdelnabi, Marawan Elmssary, Jasmine Sekhon, Juthipong Benjanuwattra Lancet - cardiovascular
  A 20-year-old daycare teacher presented to our hospital reporting a generalised erythematous maculopapular rash. The patient also had a fever, myalgia, nausea, reduced urine output, peripheral oedema, and dyspnoea on exertion. She reported that the rash had rapidly increased in size over the (...) (The Lancet 399, 10338 (2022))

13 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:13
  [Articles] The heart-brain axis: A proteomics study of meditation on the cardiovascular system of Tibetan Monks - Ting Xue, Benjamin Chiao, Tianjiao Xu, Han Li, Kai Shi, Ying Cheng, Yuan Shi, Xiaoli Guo, Shanbao Tong, Menglin Guo, Soo Hong Chew, Richard P. Ebstein, Donghong Cui Lancet - cardiovascular
  To our knowledge, this work is the first well-controlled proteomics investigation of long-term meditation, which opens up a window for individuals characterized by a sedentary lifestyle to improve their cardiovascular health with an accessible method practised for more than two (...) (eBioMedicine 80, (2022))

12 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 21:52
  [Articles] Association of gamma-glutamyltransferase levels with total mortality, liver-related and cardiovascular outcomes: A prospective cohort study in the UK Biobank - Frederick K Ho, Lyn D Ferguson, Carlos A Celis-Morales, Stuart R Gray, Ewan Forrest, William Alazawi, Jason MR Gill, Srinivasa Vittal Katikireddi, John GF Cleland, Paul Welsh, Jill P Pell, Naveed Sattar Lancet - cardiovascular
  Our study suggests that a modest elevation in GGT levels should trigger a discussion with the individual to review diet and lifestyle including alcohol intake and consideration of formal liver disease and CV risk assessment if not previously (...) (eClinicalMedicine 48, (2022))

10 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:13
  [Comment] Intersectionality and genetic ancestry: New methods to solve old problems - Carlos D. Vera, McKay Mullen, Navjot Minhas, Joseph C. Wu Lancet - cardiovascular
  Racial divisiveness is a known contributing factor to negative health outcomes such as increased chronic disease among minority populations. We need innovative studies to bridge these diversity gaps in health and a paradigm shift in our approaches. Certainly, there is strong motivation to close (...) (eBioMedicine 80, (2022))

5 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 12:30
  [Series] Menopause: a cardiometabolic transition - Rossella E Nappi, Peter Chedraui, Irene Lambrinoudaki, Tommaso Simoncini Lancet - cardiovascular
  Menopause is often a turning point for women's health worldwide. Increasing knowledge from experimental data and clinical studies indicates that cardiometabolic changes can manifest at the menopausal transition, superimposing the effect of ageing onto the risk of cardiovascular disease. The (...) (The Lancet Diabetes & Endocrinology 10, 6 (2022))

3 May

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:16
  [Articles] Epidemiology, management, and outcomes of atrial fibrillation among 30 million citizens in Shanghai, China from 2015 to 2020: A medical insurance database study - Mu Chen, Cheng Li, Peng Liao, Xin Cui, Wenqi Tian, Qunshan Wang, Jian Sun, Mei Yang, Li Luo, Hong Wu, Yi-Gang Li Lancet - cardiovascular
  The burdens of AF and AF-related outcomes in Shanghai are high. Management of AF is markedly improved in recent years, and was not or only slightly impeded by the COVID-19 pandemic. There are sex differences in the prevalence, management, and outcomes of (...) (The Lancet Regional Health – Western Pacific 23, (2022))
• 19:16
  [Articles] Aortic arch calcification and risk of all-cause mortality and cardiovascular disease: The Guangzhou Biobank Cohort Study - Wen Bo Tian, Wei Sen Zhang, Chao Qiang Jiang, Xiang Yi Liu, Ya Li Jin, Tai Hing Lam, Kar Keung Cheng, Lin Xu Lancet - cardiovascular
  As chest X-ray has been performed commonly for health screening and in hospital patients when first admitted, AAC measured by chest X-ray can be further applied to assist cardiovascular risk stratification in the community and clinical (...) (The Lancet Regional Health – Western Pacific 23, (2022))

30 April

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] A village doctor-led multifaceted intervention for blood pressure control in rural China: an open, cluster randomised trial - Yingxian Sun, Jianjun Mu, Dao Wen Wang, Nanxiang Ouyang, Liying Xing, Xiaofan Guo, Chunxia Zhao, Guocheng Ren, Ning Ye, Ying Zhou, Jun Wang, Zhao Li, Guozhe Sun, Ruihai Yang, Chung-Shiuan Chen, Jiang He, CRHCP Study Group Lancet - cardiovascular
  Compared with enhanced usual care, village doctor-led intervention resulted in statistically significant improvements in blood pressure control among rural residents in China. This feasible, effective, and sustainable implementation strategy could be scaled up in rural China and other (...) (The Lancet 399, 10339 (2022))

14 April

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 06:41
  [Correspondence] Cerebral venous thrombosis after COVID-19 vaccines: Do we know the mechanism? - Cesare de Gregorio, Giuseppe Calcaterra, Nicholas G. Kounis, Pier Paolo Bassareo, Jawahar L. Mehta Lancet - cardiovascular
  The Covid-19 pandemic has affected the world community for over 2 years. Since December 2020, most countries started with Covid-19 vaccination programmes using messenger RNA (BNT162b2 and mRNA-1273/CX-024414) and adenovirus vector (ChAdOx1nCoV-19 and JNJ-78436735) vaccines, with an (...) (The Lancet Regional Health – Europe 16, (2022))

12 April

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] Myopericarditis following COVID-19 vaccination and non-COVID-19 vaccination: a systematic review and meta-analysis - Ryan Ruiyang Ling, Kollengode Ramanathan, Felicia Liying Tan, Bee Choo Tai, Jyoti Somani, Dale Fisher, Graeme MacLaren Lancet - cardiovascular
  The overall risk of myopericarditis after receiving a COVID-19 vaccine is low. However, younger males have an increased incidence of myopericarditis, particularly after receiving mRNA vaccines. Nevertheless, the risks of such rare adverse events should be balanced against the risks of COVID-19 (...) (The Lancet Respiratory Medicine (2022))

4 April

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 14:30
  [Articles] Aggressive intraoperative warming versus routine thermal management during non-cardiac surgery (PROTECT): a multicentre, parallel group, superiority trial - Daniel I Sessler, Lijian Pei, Kai Li, Shusen Cui, Matthew T V Chan, Yuguang Huang, Jingxiang Wu, Xuemei He, Gausan R Bajracharya, Eva Rivas, Carmen K M Lam, PROTECT Investigators Lancet - cardiovascular
  The incidence of a 30-day composite of major cardiovascular outcomes did not differ significantly in patients randomised to 35·5°C and to 37°C. At least over a 1·5°C range from very mild hypothermia to full normothermia, there was no evidence that any substantive outcome varied. Keeping core (...) (The Lancet 399, 10337 (2022))

21 March

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:12
  [Articles] Body mass index in adolescence, risk of type 2 diabetes and associated complications: A nationwide cohort study of men - Andréasson Karin, Edqvist Jon, Adiels Martin, Björck Lena, Lindgren Martin, Sattar Naveed, Lind Marcus, Åberg Maria, Rosengren Annika Lancet - cardiovascular
  Rising adolescent BMI was associated with increased risk of type 2 diabetes diagnosed at a younger age, with poorer metabolic control, and a greater prevalence of albuminuria, all suggestive of worse prognosis. (eClinicalMedicine 46, (2022))

6 March

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:16
  [Articles] Cardiovascular health and healthy longevity in people with and without cardiometabolic disease: A prospective cohort study - Chenjie Xu, Pengjie Zhang, Zhi Cao Lancet - cardiovascular
  An ideal CVH is associated with a lower risk of premature mortality and longer life expectancy whether in general population or CMD patients. Our study highlights the benefits of maintaining better CVH across the life course and calls attention to the need for comprehensive strategies (healthy (...) (eClinicalMedicine 45, (2022))

4 March

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:12
  [Health Policy] 2021 World Health Organization guideline on pharmacological treatment of hypertension: Policy implications for the region of the Americas - Norm R.C. Campbell, Melanie Paccot Burnens, Paul K. Whelton, Sonia Y. Angell, Marc G. Jaffe, Jennifer Cohn, Alfredo Espinosa Brito, Vilma Irazola, Jeffrey W. Brettler, Edward J. Roccella, Javier Isaac Maldonado Figueredo, Andres Rosende, Pedro Ordunez Lancet - cardiovascular
  Cardiovascular disease (CVD) is the leading cause of death in the Americas and raised blood pressure accounts for over 50% of CVD. In the Americas over a quarter of adult women and four in ten adult men have hypertension and the diagnosis, treatment and control are suboptimal. In 2021, the (...) (The Lancet Regional Health – Americas 9, (2022))

1 March

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Articles] Use of statins for the prevention of cardiovascular disease in 41 low-income and middle-income countries: a cross-sectional study of nationally representative, individual-level data - Maja E Marcus, Jennifer Manne-Goehler, Michaela Theilmann, Farshad Farzadfar, Sahar Saeedi Moghaddam, Mohammad Keykhaei, Amirali Hajebi, Scott Tschida, Julia M Lemp, Krishna K Aryal, Matthew Dunn, Corine Houehanou, Silver Bahendeka, Peter Rohloff, Rifat Atun, Till W Bärnighausen, Pascal Geldsetzer, Manuel Ramirez-Zea, Vineet Chopra, Michele Heisler, Justine I Davies, Mark D Huffman, Sebastian Vollmer, David Flood Lancet - cardiovascular
  In a diverse sample of LMICs, statins are used by about one in ten eligible people for the primary prevention of cardiovascular diseases and one in five eligible people for secondary prevention. There is an urgent need to scale up statin use in LMICs to achieve WHO targets. Policies and (...) (The Lancet Global Health 10, 3 (2022))

12 February

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Clinical Picture] Under-sensing by a temporary pacemaker after cardiac surgery and ventricular fibrillation - Konstantinos C Theodoropoulos, Alexandra Liakopoulou, Sokratis Tsagkaropoulos, George Kassimis, Polychronis Antonitsis, Kyriakos Anastasiadis Lancet - cardiovascular
  An 80-year-old man with a 6-month-history of shortness of breath on minimal exertion and fatigue was admitted to our unit for a planned operation to replace his stenotic aortic valve. The surgery was uneventful and a temporary ventricular epicardial pacing lead was placed on the free wall of (...) (The Lancet 399, 10325 (2022))

1 February

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 15:15
  [Articles] Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial - Sanjiv J Shah, Barry A Borlaug, Eugene S Chung, Donald E Cutlip, Philippe Debonnaire, Peter S Fail, Qi Gao, Gerd Hasenfuß, Rami Kahwash, David M Kaye, Sheldon E Litwin, Philipp Lurz, Joseph M Massaro, Rajeev C Mohan, Mark J Ricciardi, Scott D Solomon, Aaron L Sverdlov, Vijendra Swarup, Dirk J van Veldhuisen, Sebastian Winkler, Martin B Leon, REDUCE LAP-HF II investigators Lancet - cardiovascular
  Placement of an atrial shunt device did not reduce the total rate of heart failure events or improve health status in the overall population of patients with heart failure and ejection fraction of greater than or equal to 40%. (The Lancet 399, 10330 (2022))

28 January

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:14
  [Review] Generating 3D human cardiac constructs from pluripotent stem cells - Chang Liu, Xing Feng, Guoping Li, Priyanka Gokulnath, Junjie Xiao Lancet - cardiovascular
  Human pluripotent stem cell (hPSC) technology has offered nearly infinite opportunities to model all kinds of human diseases in vitro. Cardiomyocytes derived from hPSCs have proved to be efficient tools for cardiac disease modeling, drug screening and pathological mechanism studies. In this (...) (eBioMedicine 76, (2022))

25 January

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:12
  [Articles] Impact of socioeconomic position on initiation of SGLT-2 inhibitors or GLP-1 receptor agonists in patients with type 2 diabetes – a Danish nationwide observational study - Alexander C. Falkentoft, Julie Andersen, Mariam Elmegaard Malik, Christian Selmer, Peter Haulund Gæde, Peter Bisgaard Staehr, Mark A. Hlatky, Emil Fosbøl, Lars Køber, Christian Torp-Pedersen, Gunnar H. Gislason, Thomas Alexander Gerds, Morten Schou, Niels E. Bruun, Anne-Christine Ruwald Lancet - cardiovascular
  Despite a universal healthcare system, low socioeconomic position was consistently associated with a lower probability of initiating a SGLT-2i or a GLP-1RA. These disparities may widen the future socioeconomic gap in cardiovascular (...) (The Lancet Regional Health – Europe 14, (2022))
• 07:15
  [Articles] Immune response to a conserved enteroviral epitope of the major capsid VP1 protein is associated with lower risk of cardiovascular disease - Nadežda Pupina, Annela Avarlaid, Helle Sadam, Arno Pihlak, Mariliis Jaago, Jürgen Tuvikene, Annika Rähni, Anu Planken, Margus Planken, Eija Kalso, Pentti J. Tienari, Janne K. Nieminen, Mikko R.J. Seppänen, Antti Vaheri, Dan Lindholm, Juha Sinisalo, Pirkko Pussinen, Tõnis Timmusk, Kaia Palm Lancet - cardiovascular
  Our findings imply that antibody response to the G-I-X-D epitope is associated with polio vaccinations and that high antibody levels to this epitope could discriminate healthy individuals from prospective MI patients as a blood-derived biomarker. Together, these findings highlight the (...) (eBioMedicine 76, (2022))

22 January

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:13
  [Articles] Mendelian randomization study on the causal effects of tumor necrosis factor inhibition on coronary artery disease and ischemic stroke among the general population - Xiaoying Kang, Tong Jiao, Haiyang Wang, John Pernow, Karin Wirdefeldt Lancet - cardiovascular
  Our findings do not support TNFR1 as a promising target for CAD or IS prevention among the general population. Future research is warranted to investigate whether the detrimental effect of circulating TNF on CAD and IS might be counteracted by modulating other relevant drug (...) (eBioMedicine 76, (2022))
• 00:00
  [Clinical Picture] Seizures and sideroblastic anaemia in a patient with multidrug-resistant tuberculosis - J Vigneshwaran, M Senthil Kumar, Vijayashree Raghavan, Sivagama Sundari Lancet - cardiovascular
  A 60-year-old man attended our hospital reporting generalised tiredness which had gradually developed over the past 4 weeks. (The Lancet 399, 10322 (2022))

14 January

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Viewpoint] What constitutes an appropriate empirical trial of antianginal therapy in patients with stable angina before referral for revascularisation? - William E Boden, Juan Carlos Kaski, Rasha Al-Lamee, William S Weintraub Lancet - cardiovascular
  Randomised clinical trials conducted over two decades, including the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial in patients with extensive coronary artery disease and moderate-to-severe ischaemia, and a contemporary (...) (The Lancet 399, 10325 (2022))

11 January

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Comment] Vitamin D supplementation and mortality - Inez Schoenmakers Lancet - cardiovascular
  In the Lancet Diabetes & Endocrinology, Rachel Neale and colleagues1 present their findings from D-Health, a population-based, double-blind, placebo-controlled vitamin D3 intervention trial in older Australian adults (n=21 315). It is the largest study to date to assess the effect of (...) (The Lancet Diabetes & Endocrinology 10, 2 (2022))

10 January

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:13
  [Articles] Predialysis serum lactate levels could predict dialysis withdrawal in Type 1 cardiorenal syndrome patients - Heng-Chih Pan, Tao-Min Huang, Chiao-Yin Sun, Nai-Kuan Chou, Chun-Hao Tsao, Fang-Yu Yeh, Tai-Shuan Lai, Yung-Ming Chen, Vin-Cent Wu Lancet - cardiovascular
  Serum lactate level is accurate and capable of forecasting the prognosis along with qSOFA severity for clinical decision-making for treating type 1 CRS patients. Further studies are needed to validate our results. (eClinicalMedicine 44, (2022))

8 January

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:14
  [Articles] Hypertension Defined by 2017 ACC/AHA Guideline, Ideal Cardiovascular Health Metrics, and Risk of Cardiovascular Disease: A Nationwide Prospective Cohort Study - Shujing Wu, Yu Xu, Ruizhi Zheng, Jieli Lu, Mian Li, Li Chen, Yanan Huo, Min Xu, Tiange Wang, Zhiyun Zhao, Shuangyuan Wang, Hong Lin, Meng Dai, Di Zhang, Jingya Niu, Guijun Qin, Li Yan, Qin Wan, Lulu Chen, Lixin Shi, Ruying Hu, Xulei Tang, Qing Su, Xuefeng Yu, Yingfen Qin, Gang Chen, Zhengnan Gao, Guixia Wang, Feixia Shen, Zuojie Luo, Yuhong Chen, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Qiang Li, Yiming Mu, Jiajun Zhao, Yufang Bi, Weiqing Wang, Guang Ning, China Cardiometabolic Disease and Cancer Cohort (4C) Study (...) Lancet - cardiovascular
  Stage 1 hypertension defined by the ACC/AHA identifies individuals at increased CVD risk, which can be attenuated by achieving more preferable cardiovascular health, especially in adults aged (The Lancet Regional Health – Western Pacific 20, (2022))

6 January

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] Point-of-care screening for heart failure with reduced ejection fraction using artificial intelligence during ECG-enabled stethoscope examination in London, UK: a prospective, observational, multicentre study - Patrik Bachtiger, Camille F Petri, Francesca E Scott, Se Ri Park, Mihir A Kelshiker, Harpreet K Sahemey, Bianca Dumea, Regine Alquero, Pritpal S Padam, Isobel R Hatrick, Alfa Ali, Maria Ribeiro, Wing-See Cheung, Nina Bual, Bushra Rana, Matthew Shun-Shin, Daniel B Kramer, Alex Fragoyannis, Daniel Keene, Carla M Plymen, Nicholas S Peters Lancet - cardiovascular
  A deep learning system applied to single-lead ECGs acquired during a routine examination with an ECG-enabled stethoscope can detect LVEF of 40% or lower. These findings highlight the potential for inexpensive, non-invasive, workflow-adapted, point-of-care screening, for earlier diagnosis and (...) (The Lancet Digital Health 4, 2 (2022))

1 January

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Review] The costs and benefits of senotherapeutics for human health - Marco Raffaele, Manlio Vinciguerra Lancet - cardiovascular
  Cellular senescence is a major contributor to age-related diseases in humans; however, it also has a beneficial role in physiological and pathological processes, including wound healing, host immunity, and tumour suppression. Reducing the burden of cell senescence in animal models of (...) (The Lancet Healthy Longevity 3, 1 (2022))
• 00:00
  [Articles] Association between blood pressure levels and cognitive impairment in older women: a prospective analysis of the Women's Health Initiative Memory Study - Longjian Liu, Kathleen M Hayden, Nathalie S May, Bernhard Haring, Zuolu Liu, Victor W Henderson, Jiu-Chiuan Chen, Edward J Gracely, Sylvia Wassertheil-Smoller, Stephen R Rapp Lancet - cardiovascular
  Results of our study show significant associations of hypertension and elevated SBP and PP levels with risk of mild cognitive impairment and the combined endpoint of either mild cognitive impairment or probable dementia, suggesting that intensive control of hypertension, SBP, and PP can (...) (The Lancet Healthy Longevity 3, 1 (2022))
• 00:00
  [Articles] Differences in estimates for 10-year risk of cardiovascular disease in Black versus White individuals with identical risk factor profiles using pooled cohort equations: an in silico cohort study - Ramachandran S Vasan, Edwin van den Heuvel Lancet - cardiovascular
  The PCE might generate substantially divergent cardiovascular disease risk estimates for Black versus White individuals with identical risk profiles, which could introduce race-related variations in clinical recommendations for cardiovascular disease (...) (The Lancet Digital Health 4, 1 (2022))
• 00:00
  [Articles] Water, sanitation, and hygiene for control of trachoma in Ethiopia (WUHA): a two-arm, parallel-group, cluster-randomised trial - Solomon Aragie, Dionna M Wittberg, Wondyifraw Tadesse, Adane Dagnew, Dagnachew Hailu, Ambahun Chernet, Jason S Melo, Kristen Aiemjoy, Mahteme Haile, Taye Zeru, Zerihun Tadesse, Sarah Gwyn, Diana L Martin, Benjamin F Arnold, Matthew C Freeman, Scott D Nash, E Kelly Callahan, Travis C Porco, Thomas M Lietman, Jeremy D Keenan Lancet - cardiovascular
  An integrated WASH intervention addressing the F and E components of the SAFE strategy did not prevent an increase in prevalence of ocular chlamydia following cessation of antibiotics in an area with hyperendemic trachoma. The impact of WASH in the presence of annual mass azithromycin (...) (The Lancet Global Health 10, 1 (2022))
• 00:00
  [Articles] Epidemiology of infective endocarditis in Africa: a systematic review and meta-analysis - Jean Jacques Noubiap, Jan René Nkeck, Beckly Shu Kwondom, Ulrich Flore Nyaga Lancet - cardiovascular
  As the most prevalent risk factor in Africa, rheumatic heart disease should be central in interventions to reduce the burden of infective endocarditis on the continent. In tertiary hospitals with good access to cardiac surgery, the outcomes of infective endocarditis seem relatively similar to (...) (The Lancet Global Health 10, 1 (2022))

28 December

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:13
  [Articles] Genomic insights in ascending aortic size and distensibility - Jan Walter Benjamins, Ming Wai Yeung, Yordi J. van de Vegte, M. Abdullah Said, Thijs van der Linden, Daan Ties, Luis E. Juarez-Orozco, Niek Verweij, Pim van der Harst Lancet - cardiovascular
  We identified 78 loci that provide insights into mechanisms underlying AAo size and function in the general population and provide genetic evidence for their role in aortic aneurysm development. (eBioMedicine 75, (2022))

17 December

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Personal View] Effective, disease-modifying, clinical approaches to patients with mild-to-moderate hypertriglyceridaemia - Gary F Lewis, Robert A Hegele Lancet - cardiovascular
  Plasma triglyceride concentration is easily, inexpensively, and accurately measured, and when elevated is a highly informative disease marker that identifies individuals who frequently have a host of underlying metabolic, inflammatory, and atherogenic risk factors. Although this concept aligns (...) (The Lancet Diabetes & Endocrinology 10, 2 (2022))

1 December

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Articles] Risk of acute respiratory infection and acute cardiovascular events following acute respiratory infection among adults with increased cardiovascular risk in England between 2008 and 2018: a retrospective, population-based cohort study - Jennifer A Davidson, Amitava Banerjee, Liam Smeeth, Helen I McDonald, Daniel Grint, Emily Herrett, Harriet Forbes, Richard Pebody, Charlotte Warren-Gash Lancet - cardiovascular
  People with increased cardiovascular risk but without diagnosed cardiovascular disease, measured by diagnosed hypertension or overall predicted cardiovascular risk, could benefit from influenza and pneumococcal vaccine prioritisation to reduce their risk of both acute respiratory infection and (...) (The Lancet Digital Health 3, 12 (2021))
• 00:00
  [Review] Diagnosis and treatment of primary aldosteronism - Martin Reincke, Irina Bancos, Paolo Mulatero, Ute I Scholl, Michael Stowasser, Tracy Ann Williams Lancet - cardiovascular
  Primary aldosteronism is a common cause of secondary hypertension associated with excess cardiovascular morbidities. Primary aldosteronism is underdiagnosed because it does not have a specific, easily identifiable feature and clinicians can be poorly aware of the disease. The diagnostic (...) (The Lancet Diabetes & Endocrinology 9, 12 (2021))

20 November

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Clinical Picture] Hydroxychloroquine-induced cardiomyopathy accelerated after gastric banding - Freya M Lodge, William E Moody, Sofia Tosounidou, Colin D Chue, Elizabeth Curtis, Desley A H Neil, William Bradlow Lancet - cardiovascular
  A 51-year-old woman was admitted to our hospital for investigation of blackouts occurring in the context of worsening breathlessness (New York Heart Association [NYHA] class IV) and swelling of her legs. 14 months earlier she had a gastric banding (...) (The Lancet 398, 10314 (2021))

15 November

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 14:32
  [Articles] Percutaneous coronary intervention with drug-eluting stents versus coronary artery bypass grafting in left main coronary artery disease: an individual patient data meta-analysis - Marc S Sabatine, Brian A Bergmark, Sabina A Murphy, Patrick T O'Gara, Peter K Smith, Patrick W Serruys, A Pieter Kappetein, Seung-Jung Park, Duk-Woo Park, Evald H Christiansen, Niels R Holm, Per H Nielsen, Gregg W Stone, Joseph F Sabik, Eugene Braunwald Lancet - cardiovascular
  Among patients with left main coronary artery disease and, largely, low or intermediate coronary anatomical complexity, there was no statistically significant difference in 5-year all-cause death between PCI and CABG, although a Bayesian approach suggested a difference probably exists (more (...) (The Lancet 398, 10318 (2021))
• 14:24
  [Articles] A contemporary simple risk score for prediction of contrast-associated acute kidney injury after percutaneous coronary intervention: derivation and validation from an observational registry - Roxana Mehran, Ruth Owen, Mauro Chiarito, Usman Baber, Samantha Sartori, Davide Cao, Johny Nicolas, Carlo Andrea Pivato, Matteo Nardin, Prakash Krishnan, Annapoorna Kini, Samin Sharma, Stuart Pocock, George Dangas Lancet - cardiovascular
  A contemporary simple risk score based on readily available variables from patients undergoing PCI can accurately discriminate the risk of contrast-associated acute kidney injury, the occurrence of which is strongly associated with subsequent (...) (The Lancet 398, 10315 (2021))

6 November

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:14
  [Review] Vitamin B12 and gut-brain homeostasis in the pathophysiology of ischemic stroke - William Roth, Mansour Mohamadzadeh Lancet - cardiovascular
  Stroke is a leading cause of morbidity and mortality worldwide. It inflicts immeasurable suffering on patients and their loved ones and carries an immense social cost. Efforts to mitigate the impact of stroke have focused on identifying therapeutic targets for the prevention and treatment. The (...) (eBioMedicine 73, (2021))

29 October

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Health Policy] Primary stroke prevention worldwide: translating evidence into action - Mayowa O Owolabi, Amanda G Thrift, Ajay Mahal, Marie Ishida, Sheila Martins, Walter D Johnson, Jeyaraj Pandian, Foad Abd-Allah, Joseph Yaria, Hoang T Phan, Greg Roth, Seana L Gall, Richard Beare, Thanh G Phan, Robert Mikulik, Rufus O Akinyemi, Bo Norrving, Michael Brainin, Valery L Feigin, Stroke Experts Collaboration Group Lancet - cardiovascular
  Stroke is the second leading cause of death and the third leading cause of disability worldwide and its burden is increasing rapidly in low-income and middle-income countries, many of which are unable to face the challenges it imposes. In this Health Policy paper on primary stroke prevention, (...) (The Lancet Public Health 7, 1 (2022))

28 October

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses - Emerging Risk Factors Collaboration/EPIC-CVD/Vitamin D Studies Collaboration Lancet - cardiovascular
  Stratified Mendelian randomisation analyses suggest a causal relationship between 25(OH)D concentrations and mortality for individuals with low vitamin D status. Our findings have implications for the design of vitamin D supplementation trials, and potential disease prevention (...) (The Lancet Diabetes & Endocrinology 9, 12 (2021))

14 October

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:12
  [Research paper] Deep learning evaluation of biomarkers from echocardiogram videos - J Weston Hughes, Neal Yuan, Bryan He, Jiahong Ouyang, Joseph Ebinger, Patrick Botting, Jasper Lee, John Theurer, James E. Tooley, Koen Nieman, Matthew P. Lungren, David H. Liang, Ingela Schnittger, Jonathan H. Chen, Euan A. Ashley, Susan Cheng, David Ouyang, James Y. Zou Lancet - cardiovascular
  These results show that deep learning applied to diagnostic imaging can provide additional clinical value and identify phenotypic information beyond current imaging interpretation methods. (eBioMedicine 73, (2021))

8 October

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:13
  [Research paper] Clinical outcomes of Sacubitril/Valsartan in patients with acute heart failure: A multi-institution study - Dong-Yi Chen, Chun-Chi Chen, Chi-Nan Tseng, Shao-Wei Chen, Shang-Hung Chang, Wen-Kuan Huang, Ming-Shien Wen, Ming-Jer Hsieh, I-Chang Hsieh Lancet - cardiovascular
  In real-world practice, initiating sacubitril/valsartan therapy among patients with HFrEF who were hospitalized for acute HF was associated with a lower rate of rehospitalization for HF and death compared with ACEI/ARB therapy. (eClinicalMedicine 41, (2021))

2 October

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Clinical Picture] Cardiac findings in tuberous sclerosis complex - Sjoerd Bouwmeester, Irene E G van Hellemond, Pieter-Jan Vlaar, Johannes C Post Lancet - cardiovascular
  A 32-year-old woman presented to our department for an evaluation of possible cardiac manifestations of tuberous sclerosis complex. (The Lancet 398, 10307 (2021))

28 September

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Comment] Statins for Graves' orbitopathy: a new tool for prevention and treatment? - Luigi Bartalena, Eliana Piantanida, Maria Laura Tanda Lancet - cardiovascular
  Graves' orbitopathy, which affects about 25–30% of newly diagnosed patients with hyperthyroidism due to Graves' disease,1 is a multifactorial autoimmune disease causing inflammation and remodelling of orbital tissues, with relevant clinical manifestations heavily effecting the quality of life of (...) (The Lancet Diabetes & Endocrinology 9, 11 (2021))
• 00:30
  [Articles] Statins for Graves' orbitopathy (STAGO): a phase 2, open-label, adaptive, single centre, randomised clinical trial - Giulia Lanzolla, Elena Sabini, Marenza Leo, Francesca Menconi, Roberto Rocchi, Angela Sframeli, Paolo Piaggi, Marco Nardi, Claudio Marcocci, Michele Marinò Lancet - cardiovascular
  Addition of oral atorvastatin to an ivGC regimen improved Graves' orbitopathy outcomes in patients with moderate-to-severe, active eye disease who were hypercholesterolaemic. Future phase 3 studies, which could potentially recruit patients regardless of low-density lipoprotein cholesterol (...) (The Lancet Diabetes & Endocrinology 9, 11 (2021))

21 September

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] Non-alcoholic fatty liver disease and risk of fatal and non-fatal cardiovascular events: an updated systematic review and meta-analysis - Alessandro Mantovani, Alessandro Csermely, Graziana Petracca, Giorgia Beatrice, Kathleen E Corey, Tracey G Simon, Christopher D Byrne, Giovanni Targher Lancet - cardiovascular
  NAFLD is associated with an increased long-term risk of fatal or non-fatal CVD events. CVD risk is further increased with more advanced liver disease, especially with higher fibrosis stage. These results provide evidence that NAFLD might be an independent risk factor for CVD morbidity and (...) (The Lancet Gastroenterology & Hepatology 6, 11 (2021))

15 September

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:13
  [Research Paper] Reversing pathology in a preclinical model of Alzheimer's disease by hacking cerebrovascular neoangiogenesis with advanced cancer therapeutics - Chaahat S.B. Singh, Kyung Bok Choi, Lonna Munro, Hong Yue Wang, Cheryl G. Pfeifer, Wilfred A. Jefferies Lancet - cardiovascular
  Modulation of neoangiogenesis, in an analogous approach to those used to treat aberrant vascularization in cancer and also in the wet form of age-related macular degeneration (AMD), provides an alternative therapeutic strategy for intervention in AD that warrants clinical (...) (eBioMedicine 71, (2021))

8 September

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC) - EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC) Lancet - cardiovascular
  Familial hypercholesterolaemia is diagnosed late. Guideline-recommended LDL cholesterol concentrations are infrequently achieved with single-drug therapy. Cardiovascular risk factors and presence of coronary disease were lower among non-index cases, who were diagnosed earlier. Earlier detection (...) (The Lancet 398, 10312 (2021))

4 September

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:13
  [Research paper] E2A ablation enhances proportion of nodal-like cardiomyocytes in cardiac-specific differentiation of human embryonic stem cells - Xiuya Li, Fei Gao, Xiaochen Wang, Qianqian Liang, Aobing Bai, Zhuo Liu, Xinyun Chen, Ermin Li, Sifeng Chen, Chao Lu, Ruizhe Qian, Ning Sun, Ping Liang, Chen Xu Lancet - cardiovascular
  Our study revealed a new role for E2A during directed cardiac differentiation of hESCs and may provide new clues for enhancing induction efficiency of SAN-like cardiomyocytes from hPSCs in the future. (eBioMedicine 71, (2021))

1 September

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Articles] Effectiveness of workplace wellness programmes for dietary habits, overweight, and cardiometabolic health: a systematic review and meta-analysis - José L Peñalvo, Diana Sagastume, Elly Mertens, Irina Uzhova, Jessica Smith, Jason H Y Wu, Eve Bishop, Jennifer Onopa, Peilin Shi, Renata Micha, Dariush Mozaffarian Lancet - cardiovascular
  Workplace wellness programmes are associated with improvements in specific dietary, anthropometric, and cardiometabolic risk indicators. The heterogeneity identified in study designs and results should be considered when using these programmes as strategies to improve cardiometabolic (...) (The Lancet Public Health 6, 9 (2021))

29 August

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 10:30
  [Articles] Fixed-dose combination therapies with and without aspirin for primary prevention of cardiovascular disease: an individual participant data meta-analysis - Philip Joseph, Gholamreza Roshandel, Peggy Gao, Prem Pais, Eva Lonn, Denis Xavier, Alvaro Avezum, Jun Zhu, Lisheng Liu, Karen Sliwa, Habib Gamra, Shrikant I Bangdiwala, Koon Teo, Rafael Diaz, Antonio Dans, Patricio Lopez-Jaramillo, Dorairaj Prabhakaran, Jose Maria Castellano, Valentin Fuster, Anthony Rodgers, Mark D Huffman, Jackie Bosch, Gilles R Dagenais, Reza Malekzadeh, Salim Yusuf, Polypill Trialists' Collaboration Lancet - cardiovascular
  Fixed-dose combination treatment strategies substantially reduce cardiovascular disease, myocardial infarction, stroke, revascularisation, and cardiovascular death in primary cardiovascular disease prevention. These benefits are consistent irrespective of cardiometabolic risk (...) (The Lancet 398, 10306 (2021))
• 08:00
  [Articles] Initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial - Clara K Chow, Emily R Atkins, Graham S Hillis, Mark R Nelson, Christopher M Reid, Markus P Schlaich, Peter Hay, Kris Rogers, Laurent Billot, Michael Burke, John Chalmers, Bruce Neal, Anushka Patel, Tim Usherwood, Ruth Webster, Anthony Rodgers, QUARTET Investigators Lancet - cardiovascular
  A strategy with early treatment of a fixed-dose quadruple quarter-dose combination achieved and maintained greater blood pressure lowering compared with the common strategy of starting monotherapy. This trial demonstrated the efficacy, tolerability, and simplicity of a quadpill-based (...) (The Lancet 398, 10305 (2021))

27 August

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 14:30
  [Articles] Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial - JoAnn Lindenfeld, Michael R Zile, Akshay S Desai, Kunjan Bhatt, Anique Ducharme, Douglas Horstmanshof, Selim R Krim, Alan Maisel, Mandeep R Mehra, Sara Paul, Samuel F Sears, Andrew J Sauer, Frank Smart, Marcel Zughaib, Paige Castaneda, Jean Kelly, Nessa Johnson, Poornima Sood, Greg Ginn, John Henderson, Philip B Adamson, Maria Rosa Costanzo Lancet - cardiovascular
  Haemodynamic-guided management of heart failure did not result in a lower composite endpoint rate of mortality and total heart failure events compared with the control group in the overall study analysis. However, a pre-COVID-19 impact analysis indicated a possible benefit of (...) (The Lancet 398, 10304 (2021))

21 August

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] Selonsertib in adults with pulmonary arterial hypertension (ARROW): a randomised, double-blind, placebo-controlled, phase 2 trial - Stephan Rosenkranz, Jeremy Feldman, Vallerie V McLaughlin, Franz Rischard, Tobias J Lange, R James White, Andrew J Peacock, Felix Gerhardt, Ramin Ebrahimi, Gabriel Brooks, Carol Satler, Robert P Frantz, ARROW Study Group Lancet - cardiovascular
  Selonsertib once daily for 24 weeks did not lead to a significant reduction in pulmonary vascular resistance or to clinical improvement in patients with PAH, but appeared to be safe and well tolerated. Although these data do not support the clinical use of selonsertib in PAH, further study of (...) (The Lancet Respiratory Medicine 10, 1 (2022))

11 August

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 21:54
  [Research paper] Epigenetic and senescence markers indicate an accelerated ageing-like state in women with preeclamptic pregnancies - Sonja Suvakov, Ranine Ghamrawi, Hajrunisa Cubro, Haitao Tu, Wendy M. White, Yvonne S. Butler Tobah, Natasa M. Milic, Joseph P. Grande, Julie M. Cunningham, Fouad T. Chebib, Larissa G.P. Langhi Prata, Yi Zhu, Tamara Tchkonia, James L. Kirkland, Karl A. Nath, Aleksandar Milosavljevic, Vesna D. Garovic Lancet - cardiovascular
  Taken together, our results identify senescence as one of the mechanisms underpinning the pathophysiology of preeclampsia. Therapeutic strategies that target senescent cells may offer novel mechanism-based treatments for preeclampsia. (eBioMedicine 70, (2021))

7 August

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:00
  [Clinical Picture] Categorising myocardial infarction with advanced cardiovascular imaging - Evangelos Tzolos, Rong Bing, David E Newby, Marc R Dweck Lancet - cardiovascular
  A 66-year-old man collapsed at home with chest pain. He was found by paramedics to be in ventricular fibrillation leading to a cardiac arrest. A post-resuscitation electrocardiogram showed sinus rhythm and inferolateral ST-segment elevation. On arrival at our department he had an emergency (...) (The Lancet 398, 10299 (2021))

6 August

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:13
  [Research paper] Electrocardiographic manifestations of COVID-19: Effect on cardiac activation and repolarization - Avni Thakore, James Nguyen, Simcha Pollack, Stefan Muehlbauer, Benjamin Chi, Derek Knight, Bhoomi Mehrotra, Joshua Stern, J. Jane Cao, Charles Lucore, Joseph Levine Lancet - cardiovascular
  QRS and QTc intervals are early markers for COVID-19 disease progression and mortality. ECG, a readily accessible tool, identifies cardiac involvement and may be used to predict disease course. (eClinicalMedicine 39, (2021))

31 July

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 22:52
  [Research paper] Impact of residual thrombus burden on ventricular deformation after acute myocardial infarction: A sub-analysis from an intravascular optical coherence tomography study - Jinying Zhou, Shiqin Yu, Peng Zhou, Chen Liu, Zhaoxue Sheng, Jiannan Li, Runzhen Chen, Hongbing Yan, Shihua Zhao Lancet - cardiovascular
  Larger residual thrombus burden was associated with worse GRS and GCS but not GLS after a first anterior myocardial infarction. (eClinicalMedicine 39, (2021))
• 22:37
  [Research paper] A cross-sectional analysis of racial differences in accelerated aging and cognitive function among patients with atrial fibrillation: The SAGE-AF study - Sarah N. Forrester, David D. McManus, Jane S. Saczynski, Isabelle C. Pierre-Louis, Benita A. Bamgbade, Catarina I. Kiefe Lancet - cardiovascular
  Non-White AF patients are functionally “older” than their White counterparts and experience a stronger deleterious association between AccA and cognition. These findings underscore the importance of taking functional age into account when treating patients with AF, particularly non-White (...) (eClinicalMedicine 39, (2021))

28 July

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:12
  [Research paper] Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial - Ayodeji Awoyemi, Cristiane Mayerhofer, Alex S. Felix, Johannes R. Hov, Samuel D. Moscavitch, Knut Tore Lappegård, Anders Hovland, Sigrun Halvorsen, Bente Halvorsen, Ida Gregersen, Asbjørn Svardal, Rolf K. Berge, Simen H. Hansen, Alexandra Götz, Kristian Holm, Pål Aukrust, Sissel Åkra, Ingebjørg Seljeflot, Svein Solheim, Andrea Lorenzo, Lars Gullestad, Marius Trøseid, Kaspar Broch Lancet - cardiovascular
  Three months’ treatment with Saccharomyces boulardii or rifaximin on top of SoC had no significant effect on LVEF, microbiota diversity, or the measured biomarkers in our population with HF. (eBioMedicine 70, (2021))

24 July

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:12
  [Research paper] Shotgun mass spectrometry-based lipid profiling identifies and distinguishes between chronic inflammatory diseases - Rune Matthiesen, Chris Lauber, Julio L. Sampaio, Neuza Domingues, Liliana Alves, Mathias J. Gerl, Manuel S. Almeida, Gustavo Rodrigues, Pedro Araújo Gonçalves, Jorge Ferreira, Cláudia Borbinha, João Pedro Marto, Marisa Neves, Frederico Batista, Miguel Viana-Baptista, Jose Alves, Kai Simons, Winchil L.C. Vaz, Otilia V. Vieira Lancet - cardiovascular
  Dysregulation of the plasma lipidome is characteristic of chronic inflammatory diseases. Lipid profiling accurately identifies the diseases and in the case of CVD also identifies sub-classes. (eBioMedicine 70, (2021))

23 July

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Comment] Cardiovascular disease in type 1 diabetes: a continuing challenge - Trevor J Orchard Lancet - cardiovascular
  A diagnosis of type 1 diabetes brings many challenges: ranging from a need for frequent monitoring of blood sugars and insulin dose adjustments to avoid acute complications to the prevention of long-term complications. Foremost of these long-term complications, in terms of total burden and (...) (The Lancet Diabetes & Endocrinology 9, 9 (2021))
• 00:30
  [Articles] Long-term population-based trends in the incidence of cardiovascular disease in individuals with type 1 diabetes from Finland: a retrospective, nationwide, cohort study - Valma Harjutsalo, Drazenka Pongrac Barlovic, Per-Henrik Groop Lancet - cardiovascular
  The risk of cardiovascular disease has decreased over time in Finland in individuals with childhood-onset type 1 diabetes. However, there is still considerable excess cardiovascular disease risk in individuals with type 1 diabetes compared with the general population. These results highlight (...) (The Lancet Diabetes & Endocrinology 9, 9 (2021))

22 July

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 00:30
  [Articles] Safety and efficacy of itepekimab in patients with moderate-to-severe COPD: a genetic association study and randomised, double-blind, phase 2a trial - Klaus F Rabe, Bartolome R Celli, Michael E Wechsler, Raolat M Abdulai, Xiaodong Luo, Maarten M Boomsma, Heribert Staudinger, Julie E Horowitz, Aris Baras, Manuel A Ferreira, Marcella K Ruddy, Michael C Nivens, Nikhil Amin, David M Weinreich, George D Yancopoulos, Helene Goulaouic Lancet - cardiovascular
  The primary endpoint in the overall population was not met, subgroup analysis showed that itepekimab reduced exacerbation rate and improved lung function in former smokers with COPD. Two phase 3 clinical studies are ongoing to confirm the efficacy and safety profile of itepekimab in former (...) (The Lancet Respiratory Medicine 9, 11 (2021))

14 July

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 19:14
  [Research paper] Trends in 30-day readmissions following hospitalisation for heart failure by sex, socioeconomic status and ethnicity - Lawson C, Crothers H, Remsing S, Squire I, Zaccardi F, Davies Md, Bernhardt L, Reeves K, Lilford R, Khunti K Lancet - cardiovascular
  In HF, despite readmission reduction policies, 30-day readmissions have increased, impacting the least affluent and ethnic minority groups the most. (EClinicalMedicine 38, (2021))

7 July

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:13
  [Research paper] Atrial fibrillation epidemiology, disparity and healthcare contacts: a population-wide study of 5.6 million individuals - Sheng-Chia Chung, Reecha Sofat, Dionisio Acosta-Mena, Julie A Taylor, Pier D Lambiase, Juan P Casas, Rui Providencia Lancet - cardiovascular
  Background: We aimed to evaluate atrial fibrillation occurrence, reasons for healthcare visits, mortality, causes of death and examined patterns by relative deprivation in the UK.Methods: To study the atrial fibrillation (AF) incidence, mortality and case-fatality, we implemented a prospective (...) (The Lancet Regional Health – Europe 7, (2021))
• 07:13
  [Research paper] Inflammation and its associations with aortic stiffness, coronary artery disease and peripheral artery disease in different ethnic groups: The HELIUS Study - Charles F. Hayfron-Benjamin, Charlotte Mosterd, Anke H. Maitland - van der Zee, Daniel H. van Raalte, Albert G.B. Amoah, Charles Agyemang, Bert-Jan van den Born Lancet - cardiovascular
  our study shows that inflammatory biomarkers are unequally associated with vascular dysfunction in different ethnic groups. These observations provide opportunities for future studies aimed at assessing the predictive roles of inflammation on vascular disease in different ethnic (...) (EClinicalMedicine 38, (2021))

6 July

Lancet - cardiovascular https://www.thelancet.com/collection/001536

• 07:12
  [Research paper] Associations between lung function and future cardiovascular morbidity and overall mortality in a predominantly First Nations population: a cohort study. - Andrew J Collaro, Anne B Chang, Julie M Marchant, Mark D Chatfield, Annette Dent, Tamara Blake, Patsi Mawn, Kwun Fong, Margaret S McElrea Lancet - cardiovascular
  Reduced lung function even within the clinically normal range is associated with increased mortality, and cardiovascular disease in First Nations Australians. These findings highlight the importance of lung function optimisation and inform the need for future investment to improve outcomes in (...) (The Lancet Regional Health – Western Pacific 13, (2021))
• 00:30
  [Health Policy] Keeping an eye on eye care: monitoring progress towards effective coverage - Stuart Keel, Andreas Müller, Sandra Block, Rupert Bourne, Matthew J Burton, Somnath Chatterji, Mingguang He, Van C Lansingh, Wanjiku Mathenge, Silvio Mariotti, Debbie Muirhead, M Mansur Rabiu, Thulasiraj D Ravilla, Serge Resnikoff, Juan Carlos Silva, Ian Tapply, Theo Vos, Ningli Wang, Alarcos Cieza Lancet - cardiovascular
  The eye care sector is well positioned to contribute to the advancement of universal health coverage within countries. Given the large unmet need for care associated with cataract and refractive error, coupled with the fact that highly cost-effective interventions exist, we propose that (...) (The Lancet Global Health 9, 10 (2021))