18 March

Lancet https://www.thelancet.com/journals/lancet

• 00:00
  [Editorial] Human genome editing: ensuring responsible research - The Lancet Lancet
  In 2018, during the Second International Summit on Human Genome Editing in Hong Kong, Jiankui He shocked the world by announcing the birth of two children whose genomes he had edited using CRISPR technology. Following widespread condemnation and a criminal investigation, he was sentenced to 3 (...) (The Lancet 401, 10380 (2023))
• 00:00
  [Comment] Offline: The silencing of the South - Richard Horton Lancet
  League tables are addictive. From football to motorsport, tennis to golf, we relish following who is up and who is down. Understandably so, given that sport is fiercely competitive between individuals and teams. But universities? Provosts and Presidents of our greatest higher education (...) (The Lancet 401, 10380 (2023))
• 00:00
  [World Report] Global health experts welcome Kasai dismissal - John Zarocostas Lancet
  WHO's dismissal of Takeshi Kasai, Regional Director for the Western Pacific, could pressure WHO leadership to take decisive action in other misconduct cases. John Zarocostas reports from Geneva. (The Lancet 401, 10380 (2023))
• 00:00
  [World Report] Health and the invasion of Iraq: 20 years later - Shawn Yuan Lancet
  The legacy of the US-led invasion is still being felt across Iraqi society. Shawn Yuan reports from Baghdad. (The Lancet 401, 10380 (2023))
• 00:00
  [World Report] “Impunity” enabling South Sudan human rights violations - John Zarocostas Lancet
  A new report to the UN Human Rights Council outlines how violence is worsening health and humanitarian programmes. John Zarocostas reports from Geneva. (The Lancet 401, 10380 (2023))
• 00:00
  [Perspectives] Aftermath of the Türkiye–Syria earthquake - Danielle Villasana Lancet
  The earthquakes in Türkiye and Syria on Feb 6, 2023, will have lasting health and humanitarian impacts. Current estimates indicate more than 50 000 people have died and over 100 000 people have been injured. Thousands of buildings and much infrastructure are destroyed, with millions of people (...) (The Lancet 401, 10380 (2023))
• 00:00
  [Obituary] Samuel Lawrence Katz - Geoff Watts Lancet
  Paediatrician, virologist, and co-developer of measles vaccine. Born in Manchester, NH, USA, on May 29, 1927, he died in Chapel Hill, NC, USA, on Oct 31, 2022 aged 95 years. (The Lancet 401, 10380 (2023))
• 00:00
  [Correspondence] We cannot erase Syrians' suffering with “solidarity” and political infighting - Mouna Khaity, Mervat Alhaffar, Natasha Howard Lancet
  “The UN's failure to act quickly to save Syrian lives in the face of a humanitarian catastrophe is utterly shameful and should be a stain on its conscience.”1 Raed Al Saleh, The White Helmets (The Lancet 401, 10380 (2023))
• 00:00
  [Correspondence] Error in NHS England's BMI calculator and daily calorie recommendations - Stuart W Flint Lancet
  BMI is a calculation of height and weight to identify a person's weight status.1 BMI is calculated by a person's weight in kilograms (or pounds) divided by the square of height in metres (or feet).1 The BMI ranges are underweight (...) (The Lancet 401, 10380 (2023))
• 00:00
  [Correspondence] Firearms and blood transfusion: an inescapable disentanglement - Jeremy W Jacobs, Laura D Stephens, Jennifer S Woo, Elizabeth S Allen, Garrett S Booth Lancet
  The incidence of mass shootings in the USA continues to increase; more than 45 000 total gun deaths occurred in 2020 alone, the most on record for years with full data available.1 These statistics highlight increasing gun violence, one of the primary contributors to blood shortages. Patients (...) (The Lancet 401, 10380 (2023))
• 00:00
  [Correspondence] Chlordecone (Kepone) poisoning in the French Territories in the Americas - Dabor Resiere, Jonathan Florentin, Hatem Kallel, Rishika Banydeen, Ruddy Valentino, Moustapha Dramé, José-Louis Barnay, Papa Gueye, Bruno Mégarbane, Hossein Mehdaoui, Rémi Neviere, Toxicological Research Group on chlordecone at the University Hospital of Martinique Lancet
  For more than 40 years, two French territories in the Americas, Martinique and Guadeloupe, have been confronted with one of the biggest environmental scandals in Caribbean history due to the use of an organochlorine pesticide, chlordecone (also known under the brand name Kepone), in banana (...) (The Lancet 401, 10380 (2023))
• 00:00
  [Department of Error] Department of Error Lancet
  Purba AK, Henderson M, Baxter A, Pearce A, Katikireddi SV. To what extent does time spent on social media influence adolescent use of cigarettes and e-cigarettes: a longitudinal analysis of the UK Millennium Cohort Study. Lancet 2022; 400: S73—In this Meeting Abstract, the reference category (...) (The Lancet 401, 10380 (2023))
• 00:00
  [Department of Error] Department of Error Lancet
  Schöley J, Karlinsky A, Kobak D, Tallack C. Conflicting COVID-19 excess mortality estimates. Lancet 2023; 401: 431–32—The appendices of this Correspondence have been updated as of March 16, 2023. (The Lancet 401, 10380 (2023))
• 00:00
  [Clinical Picture] A urinary tract infection caused by Escherichia coli mucoid phenotype progresses to a pneumonia and respiratory failure - Federica Quarata, Diana Lelli, Davide Maria Biancone, Giovanni Gherardi, Raffaele Antonelli Incalzi Lancet
  A 69-year-old woman was admitted to our ward with fever and respiratory failure. 3 weeks earlier she had been treated with ciprofloxacin for a urinary tract infection, caused by Escherichia coli; she had a history of diabetes. (The Lancet 401, 10380 (2023))

11 March

Lancet https://www.thelancet.com/journals/lancet

• 00:00
  [Editorial] Long COVID: 3 years in - The Lancet Lancet
  March 11 marks 3 years since WHO declared COVID-19 to be a pandemic. While the world is determined to move on from the acute phase, at least 65 million people are estimated to struggle with long COVID, a debilitating post-infection multisystem condition with common symptoms of fatigue, (...) (The Lancet 401, 10379 (2023))
• 00:00
  [Comment] An alternative route to pertussis protection? - Kathryn M Edwards, Michael D Decker Lancet
  Around 40 years ago, growing concern in many countries about severe adverse events in infants after receipt of parenteral whole-cell pertussis vaccines combined with diphtheria and tetanus toxoids (DTP) drove the development of more highly purified acellular pertussis vaccines. These (...) (The Lancet 401, 10379 (2023))
• 00:00
  [Comment] Offline: The case for diversifying diversity - Richard Horton Lancet
  It is time to rethink our ideas about diversity. Gender equity? Anti-racism? Yes, of course, but our approach to diversity—what it means and what we do about it—is simply too narrow. The London School of Economics and Political Science (LSE) recently hosted a discussion about diversity of thought (...) (The Lancet 401, 10379 (2023))
• 00:00
  [World Report] Fresh criticisms over WHO sexual exploitation - Udani Samarasekera Lancet
  Members of an independent commission into sexual exploitation and abuse by WHO staff have slammed the organisation. Udani Samarasekera reports. (The Lancet 401, 10379 (2023))
• 00:00
  [World Report] New reform proposals for Australian health care - Sophie Cousins Lancet
  A Government report on primary care recommends a slew of changes to improve access to care. Sophie Cousins reports. (The Lancet 401, 10379 (2023))
• 00:00
  [World Report] UK position on Horizon Europe remains uncertain - Udani Samarasekera Lancet
  Despite a new post-Brexit agreement, the UK's association to the EU's flagship research programme has not been confirmed. Udani Samarasekera reports. (The Lancet 401, 10379 (2023))
• 00:00
  [Perspectives] Camara Phyllis Jones: anti-racism thought leader - Udani Samarasekera Lancet
  Family doctor and epidemiologist Camara Phyllis Jones is an anti-racism thought leader and researcher. Presently in the UK as a Leverhulme Visiting Professor in Global Health and Social Medicine at King's College London, she says: “The racism denial that characterises the US…is even more (...) (The Lancet 401, 10379 (2023))
• 00:00
  [Perspectives] Can museums overcome their colonial past? - Lioba Hirsch Lancet
  Grace Ndiritu's The Healing Pavilion is an exhibition that is felt and experienced, rather than simply visited. The work invites a reckoning with what we want decolonial futures to be. It can be seen as an attempt of institutional healing for the Wellcome Collection, London, UK, in line with (...) (The Lancet 401, 10379 (2023))
• 00:00
  [Perspectives] Saviour at sea - Rebecca Barksby Lancet
  Human cultures have always been fascinated by the ocean—as Herman Melville wrote in his novel Moby Dick: “There is, one knows not what sweet mystery about this sea, whose gently awful stirrings seem to speak of some hidden soul beneath”. At the time of Moby Dick's publication in 1851, the British (...) (The Lancet 401, 10379 (2023))
• 00:00
  [Obituary] Andrew P Goldberg - Andrew Green Lancet
  Expert in gerontology and geriatric medicine. Born in the Bronx, NY, USA, on March 12, 1945, he died of pancreatic cancer on Oct 25, 2022, in Columbia, MD, USA, aged 77 years. (The Lancet 401, 10379 (2023))
• 00:00
  [Correspondence] The need for appropriate language in the debate on medicalisation of pregnancy - Catherine Cluver, Christianne de Groot, Ben W Mol, Kellie E Murphy, Jane E Norman, Rodolfo Pacagnella, Kirsten Palmer, Liona C Poon, Daniel L Rolnik, Catherine Y Spong, Sarah J Stock, Shakila Thangaratinam, Stephen Tong, Corine Verhoeven, Lan N Vuong, Sue P Walker, Liu Xiaohua Lancet
  Although the majority of pregnancies progress smoothly and result in the birth of a healthy baby, this is not always the case. Pregnancy can have severe complications, including stillbirth, affecting eight in 1000 pregnancies in France;1 maternal hypertension, affecting 74 in 1000,2 or neonatal (...) (The Lancet 401, 10379 (2023))
• 00:00
  [Correspondence] FRENCH-ARRIVE: a serious, evidence-free, and false accusation of unethical research - Loïc Sentilhes, Joelle Belaisch Allart, Paul Berveiller, Aline Bibes, Thierry Schaeverbeke, FRENCH-ARRIVE Study Group and the Groupe de Recherche en Obstétrique et Gynécologie Lancet
  We—the investigators and Trial Steering Committee of the FRENCH-ARRIVE trial, members of the Groupe de Recherche en Obstétrique Gynécologie, representatives of the French College of Obstetrics and Gynecology, and Bordeaux University Hospital (appendix)—were stunned to read Richard Horton's1 Comment (...) (The Lancet 401, 10379 (2023))
• 00:00
  [Correspondence] International cooperation to end the COVID-19 pandemic - Zhi Qu Lancet
  The recent COVID-19 pandemic in China has brought new uncertainties to the world. I am glad that an Editorial1 has brought this situation to the attention of the international community. However, I disagree with how the editors described the international community (ie, “far from showing (...) (The Lancet 401, 10379 (2023))
• 00:00
  [Articles] Immunogenicity and safety of BPZE1, an intranasal live attenuated pertussis vaccine, versus tetanus–diphtheria–acellular pertussis vaccine: a randomised, double-blind, phase 2b trial - Cheryl Keech, Vicki E Miller, Barbara Rizzardi, Christopher Hoyle, Melinda J Pryor, Jonathan Ferrand, Ken Solovay, Marcel Thalen, Stephanie Noviello, Peter Goldstein, Andrew Gorringe, Breeze Cavell, Qiushui He, Alex-Mikael Barkoff, Keith Rubin, Camille Locht Lancet
  BPZE1 induced nasal mucosal immunity and produced functional serum responses. BPZE1 has the potential to avert B pertussis infections, which ultimately could lead to reduced transmission and diminished epidemic cycles. These results should be confirmed in large phase 3 (...) (The Lancet 401, 10379 (2023))
• 00:00
  [Clinical Picture] A planned caesarean hysterectomy for placenta accreta spectrum at 35 weeks of gestation: antenatal identification and a multidisciplinary approach to manage an increasing condition - Lara Catherine Morley, Colette Sparey, Dileep Wijeratne, Kerry Turner Lancet
  A 37-year-old woman, who was 35 weeks into a singleton pregnancy, was admitted to our hospital for a planned caesarean hysterectomy. (The Lancet 401, 10379 (2023))

10 March

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Past time for a PACTT for humanity - Ayoade Alakija Lancet
  Five fundamentals are crucial for efforts to strengthen global health security and rebuild a sense of optimism in our ability to collectively achieve equitable health for all: preparedness, access, countermeasures, tools, and trust (PACTT). The panel highlights key aspects of PACTT. In efforts (...) (The Lancet 401, 10380 (2023))

7 March

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] The catastrophic response to the earthquake in Syria: the need for corrective actions and accountability - Samer Jabbour, Aula Abbara, Abdulkarim Ekzayez, Fouad M Fouad, Mohamad Katoub, Rabie Nasser Lancet
  The Feb 6, 2023 earthquake has devastated areas in northwest Syria controlled by the Türkiye-backed Syrian National Army and extremist Hayat Tahrir Sham, and respectively run by their civilian affiliates, the Syrian Interim Government (SIG) and the Syrian Salvation Government. The earthquake (...) (The Lancet 401, 10379 (2023))

4 March

Lancet https://www.thelancet.com/journals/lancet

• 00:00
  [Perspectives] Mishal Khan: challenging inequitable status quos in global health - Rachael Davies Lancet
  Social epidemiologist Mishal Khan is no stranger to pushing boundaries. As Associate Professor at the UK's London School of Hygiene & Tropical Medicine (LSHTM) in 2018, she did an analysis with colleagues that showed stark gender and ethnicity-related disparities in progression to senior (...) (The Lancet 401, 10378 (2023))
• 00:00
  [Perspectives] Healing Long Covid: a marathon not a sprint - Nisreen A Alwan Lancet
  I have been immersed in Long Covid both personally and professionally since the summer of 2020. I experienced the condition myself, wrote and spoke about it on various national and international platforms, and did research trying to understand its features and effects. Now there is a handbook (...) (The Lancet 401, 10378 (2023))
• 00:00
  [Obituary] Ralph Lewis Sacco - Geoff Watts Lancet
  Neurologist specialising in stroke risk and prevention. He was born in Margate City, NJ, USA, on Aug 27, 1957 and died of a brain tumour in Long Island, NY, USA, on Jan 17, 2023 aged 65 years. (The Lancet 401, 10378 (2023))
• 00:00
  [Correspondence] The resurgence of dengue epidemic and climate change in India - Nitish Mondal Lancet
  Climate change is influencing the incidence of Aedes aegypti and Aedes albopictus mosquito-borne dengue illnesses. More than half of the world's population is in danger, with an annual estimate of 100–400 million infections,1 96 million clinical symptoms, and 40 000 fatalities.2 Despite evidence (...) (The Lancet 401, 10378 (2023))
• 00:00
  [Correspondence] The human rights to water and sanitation, gender equality, and the State - Léo Heller Lancet
  Isha Ray authored an interesting Review1 of my book on the human rights to water and sanitation.2 I appreciate her definition of the book's approach as a compelling “moral and political case for water and sanitation rights” and she made me proud when suggesting that it is aligned with Eleanor (...) (The Lancet 401, 10378 (2023))
• 00:00
  [Correspondence] When was mpox a public health emergency? - Stephen A Hoption Cann Lancet
  Clare Wenham and Mark Eccleston-Turner1 discussed challenges faced by WHO over when to declare an outbreak a Public Health Emergency of International Concern (PHEIC). They state the PHEIC declaration for mpox (previously known as monkeypox) could reclaim WHO's “authority in global disease (...) (The Lancet 401, 10378 (2023))
• 00:00
  [Correspondence] GBD 2019 study informs industry yet crucial questions remain unanswered - Tim Rycroft Lancet
  We join respected nutrition and health academics1,2 in requesting clarification from the GBD 2019 Risk Factors Collaborators3 about whether the data used to conclude there had been a 36-fold increase in global deaths attributed to eating red meat had been correctly scrutinised before (...) (The Lancet 401, 10378 (2023))
• 00:00
  [Correspondence] GBD 2019 study informs industry yet crucial questions remain unanswered - John Thorley Lancet
  As The Lancet approaches its 200-year anniversary, a matter that must be the justifiable source of great pride and deserving of the highest congratulations, I and the industry that my organisation represents have serious concerns that the reporting of a systematic analysis of the global burden (...) (The Lancet 401, 10378 (2023))
• 00:00
  [Correspondence] GBD 2019 study informs industry yet crucial questions remain unanswered - Nick Allen, British Meat Processors Association Lancet
  We are writing to express our concern over the potential consequences that will arise from flawed and incorrect scientific studies being used as the basis for UK Government health policy. We refer to one in particular, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 (...) (The Lancet 401, 10378 (2023))
• 00:00
  [Correspondence] GBD 2019 study informs industry yet crucial questions remain unanswered – Authors' reply - Jeffrey D Stanaway, Simon I Hay, Christopher J L Murray, GBD Risk Factor Collaborators Lancet
  In their letters, Nick Allen (representing the British Meat Processors Association), John Thorley (the Association of Independent Meat Suppliers), and Tim Rycroft (the Agriculture and Horticulture Development Board) reiterate concerns previously expressed by Alice V Stanton and colleagues1 and (...) (The Lancet 401, 10378 (2023))
• 00:00
  [Clinical Picture] Human epidermal growth factor receptor 2-positive metastatic gastric cancer in complete sustained remission with trastuzumab - Denis O’Mahony, Stephen P Power, Derek G Power Lancet
  A 71-year-old woman with a 3-month history of nausea, 5 kg weight loss, and a hypochromic microcytic anaemia (haemoglobin concentration 8·9 g/dL) was referred to our hospital by her family doctor for further investigation. (The Lancet 401, 10378 (2023))
• 00:00
  [Editorial] A decisive moment for The World Bank - The Lancet Lancet
  The next few months will be vital for The World Bank. In June, David Malpass will step down as President, following his damaging equivocations about whether fossil fuels are driving climate change. Malpass’ tenure has undermined the credibility of the Bank as a trusted source of assistance and (...) (The Lancet 401, 10378 (2023))
• 00:00
  [Comment] Offline: The willing versus the legitimate - Richard Horton Lancet
  The largest land war in Europe since World War 2. Yet NATO insists that it is not at war with Russia in Ukraine. The evidence suggests otherwise. An expanding supply of missiles, ammunition, tanks, and air defence systems is proof of direct involvement of NATO in the Russia–Ukraine conflict. (...) (The Lancet 401, 10378 (2023))
• 00:00
  [World Report] New leadership for Gavi - John Zarocostas Lancet
  Muhammad Ali Pate has been appointed to lead the vaccine organisation. John Zarocostas reports from Geneva. (The Lancet 401, 10378 (2023))
• 00:00
  [World Report] Experts warn over potential for measles in Ukraine - Ed Holt Lancet
  Ukraine has a history of large outbreaks, and experts say that the disruptions brought by Russia's invasion could trigger new cases. Ed Holt reports. (The Lancet 401, 10378 (2023))
• 00:00
  [World Report] Seeking solutions to global drugs shortages - Ferry Biedermann Lancet
  Many countries are facing shortages of common drugs—from antibiotics to stroke treatments. Ferry Biedermann looks at the causes and potential solutions. (The Lancet 401, 10378 (2023))

3 March

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Improving cardiovascular health in rural China and beyond - Lijing L Yan, Biraj M Karmacharya Lancet
  In 2021, high blood pressure claimed 11·3 million lives globally.1 High blood pressure has ranked consistently as the top modifiable risk factor globally for over 20 years. Although its prevalence is universally high, awareness, management, and control of high blood pressure are particularly (...) (The Lancet 401, 10380 (2023))
• 00:30
  [Articles] Effectiveness of a non-physician community health-care provider-led intensive blood pressure intervention versus usual care on cardiovascular disease (CRHCP): an open-label, blinded-endpoint, cluster-randomised trial - Jiang He, Nanxiang Ouyang, Xiaofan Guo, Guozhe Sun, Zhao Li, Jianjun Mu, Dao Wen Wang, Lixia Qiao, Liying Xing, Guocheng Ren, Chunxia Zhao, Ruihai Yang, Zuyi Yuan, Chang Wang, Chuning Shi, Songyue Liu, Wei Miao, Guangxiao Li, Chung-Shiuan Chen, Yingxian Sun, CRHCP Study Group Lancet
  The non-physician community health-care provider-led intensive blood pressure intervention is effective in reducing cardiovascular disease and death. (The Lancet 401, 10380 (2023))
• 00:30
  [Viewpoint] Confronting the evolution and expansion of anti-vaccine activism in the USA in the COVID-19 era - Richard M Carpiano, Timothy Callaghan, Renee DiResta, Noel T Brewer, Chelsea Clinton, Alison P Galvani, Rekha Lakshmanan, Wendy E Parmet, Saad B Omer, Alison M Buttenheim, Regina M Benjamin, Arthur Caplan, Jad A Elharake, Lisa C Flowers, Yvonne A Maldonado, Michelle M Mello, Douglas J Opel, Daniel A Salmon, Jason L Schwartz, Joshua M Sharfstein, Peter J Hotez Lancet
  Over the past two decades, anti-vaccine activism in the USA has evolved from a fringe subculture into an increasingly well organised, networked movement with important repercussions for public health. The COVID-19 pandemic has exacerbated this evolution and magnified the reach of vaccine (...) (The Lancet 401, 10380 (2023))

2 March

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Correspondence] Implausible algorithm output in UK liver transplantation allocation scheme: importance of transparency - Antony Attia, Ian A Rowe, Ewen M Harrison, Tim Gordon-Walker, Ben M Stutchfield Lancet
  Algorithm-based allocation of resource-limited health-care interventions is growing; however, concerns over transparency and bias have restricted its use.1 Transparent algorithms can be readily explained, allowing patients and clinicians to clearly understand the basis for decision making.2 In (...) (The Lancet 401, 10380 (2023))

28 February

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Department of Error] Department of Error Lancet
  Pérez-Escamilla R, Tomori C, Hernández-Cordero S, et al. Breastfeeding: crucially important, but increasingly challenged in a market-driven world. Lancet 2023; 401: 472–85—In this Series paper, reference 8 has been updated. This correction has been made to the online version as of Feb 27, (...) (The Lancet 401, 10380 (2023))

25 February

Lancet https://www.thelancet.com/journals/lancet

• 00:00
  [Editorial] Russia's invasion of Ukraine: an attack on health - The Lancet Lancet
  Russia's invasion of Ukraine, which began 1 year ago on Feb 24, has wrought huge suffering and devastation. As of Feb 6, the Office of the UN High Commissioner for Human Rights has recorded 7155 civilian fatalities and 11 662 injuries in Ukraine, although the actual figures are likely to be (...) (The Lancet 401, 10377 (2023))
• 00:00
  [Comment] Offline: ACT-A—ça suffit - Richard Horton Lancet
  The Access To COVID-19 Tools Accelerator (ACT-A) was the largest and most ambitious global effort to ensure equitable availability for anti-SARS-CoV-2 technologies—vaccines, treatments, and diagnostics. The intent deserves high praise. But the result fell far short of expectations. As Suerie (...) (The Lancet 401, 10377 (2023))
• 00:00
  [World Report] Health emergency over Brazil's Yanomami people - Jonathan Watts Lancet
  Infant mortality and disease among the Yanomami Indigenous People have soared following the encouragement of illegal mining. Jonathan Watts reports from Altamira, Brazil. (The Lancet 401, 10377 (2023))
• 00:00
  [World Report] Global maternal mortality rates stagnating - John Zarocostas Lancet
  A new UN report shows that progress in reducing deaths of mothers plateaued between 2016 and 2020. John Zarocostas reports from Geneva. (The Lancet 401, 10377 (2023))
• 00:00
  [World Report] “Things have gone seriously wrong”: global cholera surges - Talha Burki Lancet
  A series of complex health emergencies has seen a surge in cholera cases, with outbreaks in 30 countries. Talha Burki reports. (The Lancet 401, 10377 (2023))
• 00:00
  [Perspectives] Rajat Khosla: shifting power structures in global health - Aarathi Prasad Lancet
  Rajat Khosla was born in Old Delhi, India, where his grandparents, who were freedom fighters in the Indian independence movement, had migrated from Punjab before Partition. “There was a fair degree of critical consciousness in the family”, Khosla recalls, “even if their means were little. The (...) (The Lancet 401, 10377 (2023))
• 00:00
  [Perspectives] Reinventing public purpose - Michael Marmot Lancet
  Hurricane Maria devastated Puerto Rico in 2017. Entire neighbourhoods were razed to the ground and hundreds of thousands of people were displaced. An estimated 3000 people died—ie, excess deaths over those expected based on non-hurricane years. The risk of death was 45% higher in areas of low (...) (The Lancet 401, 10377 (2023))
• 00:00
  [Perspectives] 19th-century medicine and The Races of Men - Suman Seth Lancet
  At the beginning of October, 1857, The Lancet published a letter by the Scottish anatomist, Robert Knox, entitled “New Theory of Race: Celt vs Saxon”. Knox was responding to the work of the Irish physician and nationalist, John M'Elheran, who wished to celebrate the contributions of those of (...) (The Lancet 401, 10377 (2023))
• 00:00
  [Obituary] Kenneth Dawson Bagshawe - Geoff Watts Lancet
  Pioneer of treatment for choriocarcinoma. He was born in Marple near Manchester, UK, on Aug 17, 1925 and died in London, UK, on Dec 27, 2022 aged 97 years. (The Lancet 401, 10377 (2023))
• 00:00
  [Correspondence] The promise of large language models in health care - Anmol Arora, Ananya Arora Lancet
  The past few months have seen a rapid acceleration of innovation in the field of generative artificial intelligence with large language models (LLMs), capturing academic, media, and public attention. GPT-3, BERT, and ChatGPT are examples of LLMs that have been trained on swathes of the internet (...) (The Lancet 401, 10377 (2023))
• 00:00
  [Correspondence] Insurance pools' merging in China needs careful design - Yian Fang Lancet
  Chen Xinxin and colleagues' call for healthy ageing in China is encouraging.1 To address equity concerns and mobility difficulties, the policy recommendation of “establishing a unified national insurance system that encompasses all citizens, regardless of occupation, resident status, or place of (...) (The Lancet 401, 10377 (2023))
• 00:00
  [Correspondence] Insurance pools' merging in China needs careful design - Xinxin Chen, Qinqin Meng, Yafeng Wang, Yao Yao, Yaohui Zhao Lancet
  We thank Yian Fang for the letter and for allowing us to elaborate on the design of the national health insurance plan. In the Commission, we advocated a unified national plan because current insurance plans, with mostly city-level pooling, hinder healthy (...) (The Lancet 401, 10377 (2023))
• 00:00
  [Correspondence] Rebuilding an agenda for Brazilian science and technology - Carol Góis Leandro, Conrado Rodrigues, Pedro Carelli, Charles Morphy D Santos Lancet
  Brazil has had ongoing political crises and instability in the past 6 years, and federal funding for science and technology has reached an all-time low. (The Lancet 401, 10377 (2023))
• 00:00
  [Correspondence] China's COVID-19 reopening measures—warriors and weapons - Shujie Huang, Zhen Gao, Sichao Wang Lancet
  On Dec 7, 2022, the Chinese Government issued the New 10 epidemic prevention policy1 and announced that China's dynamic zero-COVID policy, which had been adhered to for nearly 3 years, has officially moved towards reopening. However, in the face of the omicron variant with an average basic (...) (The Lancet 401, 10377 (2023))
• 00:00
  [Correspondence] Celebration of 200 years - Nick Black Lancet
  The Lancet's extensive coverage of its achievements is a timely reminder of the great contribution this journal has made to advance medical care. Although the timeline highlights many substantial scientific contributions, the extraordinary role The Lancet played in the reform of the medical (...) (The Lancet 401, 10377 (2023))
• 00:00
  [Department of Error] Department of Error Lancet
  Feikin DR, Melissa MH, Abu-Raddad LJ, et al. Duration of effectiveness of vaccines against SARS-CoV-2 infection and COVID-19 disease: results of a systematic review and meta-regression. Lancet 2022; 399: 924–44—The methods for the meta-regression section in the appendix of this Article have been (...) (The Lancet 401, 10377 (2023))
• 00:00
  [Clinical Picture] A professional sportsperson with subtle motor symptoms and signs: early-onset Parkinson's disease - Daniel Ferreira, Rui Araújo Lancet
  A 41-year-old professional hockey referee was referred to our clinic with an 8-month history of walking difficulties; previously he had consulted several orthopaedic surgeons and had undergone physical therapy—with limited benefit—for a presumed knee injury. The patient had no notable medical (...) (The Lancet 401, 10377 (2023))

24 February

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Hyperfractionation for reirradiation of recurrent nasopharyngeal carcinoma - Melvin L K Chua, Victor H F Lee, Anne W M Lee Lancet
  Treatment of locoregionally recurrent nasopharyngeal carcinoma presents a profound clinical challenge. If surgical expertise is available, the consensus among international experts recommends surgery for resectable recurrence.1 This approach is supported by data from a randomised trial by Liu (...) (The Lancet 401, 10380 (2023))
• 00:30
  [Articles] Hyperfractionation compared with standard fractionation in intensity-modulated radiotherapy for patients with locally advanced recurrent nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial - Rui You, You-Ping Liu, Yu-Long Xie, Chao Lin, Chong-Yang Duan, Dong-Ping Chen, Yi Pan, Bin Qi, Xiong Zou, Ling Guo, Jing-Yu Cao, Yi-Nuan Zhang, Zhi-Qiang Wang, Yong-Long Liu, Yan-Feng Ouyang, Kai Wen, Qi Yang, Ruo-Qi Xie, Hui-Feng Li, Xiao-Tong Duan, Xi Ding, Lan Peng, Si-Yuan Chen, Jiong-Lin Liang, Zheng-Kai Feng, Tian-Liang Xia, Rui-Ling Xie, Rou Jiang, Chen-Mei Gu, Rong-Zeng Liu, Rui Sun, Xin Yang, Li-Zhi Liu, Li Ling, Qing Liu, Wai Tong Ng, Yi-Jun Hua, Pei-Yu Huang, Ming-Yuan (...) Lancet
  Hyperfractionated intensity-modulated radiotherapy could significantly decrease the rate of severe late complications and improve overall survival among patients with locally advanced recurrent nasopharyngeal carcinoma. Our findings suggest that hyperfractionated intensity-modulated (...) (The Lancet 401, 10380 (2023))

23 February

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] After a far-right government: challenges for Brazil's Unified Health System - Adriano Massuda, Rafael Dall'Alba, Arthur Chioro, José Gomes Temporão, Marcia C Castro Lancet
  The implementation of the Unified Health System (Sistema Único de Saúde [SUS]) was a milestone for Brazil. Nearly four decades after the 8th National Health Conference declared that health is a universal right and a governmental responsibility, as enshrined in Brazil's 1988 Federal Constitution, (...) (The Lancet 401, 10380 (2023))

22 February

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] The war in Ukraine 1 year on: the need to strategise for the long-term health of Ukrainians - Paul B Spiegel, Pavlo Kovtoniuk, Katarzyna Lewtak Lancet
  1 year has passed since the unprovoked war by Russia on Ukraine began on Feb 24, 2022. The horrendous suffering and deaths among Ukrainian civilians and the massive loss of life in the military on both sides are tragic. The UN estimates there have been 7155 conflict-related civilian deaths with (...) (The Lancet 401, 10377 (2023))

21 February

Lancet https://www.thelancet.com/journals/lancet

• 20:32
  [Comment] Fulminant mpox as an AIDS-defining condition: useful or stigmatising? - Isaac Núñez, Sergio Iván Valdés-Ferrer Lancet
  The 2022 mpox outbreak was declared a public health emergency of international concern in July, 2022, by WHO within 2 months of the initial reports.1 With over 85 000 confirmed cases and 86 deaths, the outbreak has mainly affected men, many of whom identify as men who have sex with men (...) (The Lancet 401, 10380 (2023))
• 20:32
  [Articles] Mpox in people with advanced HIV infection: a global case series - Oriol Mitjà, Andrea Alemany, Michael Marks, Jezer I Lezama Mora, Juan Carlos Rodríguez-Aldama, Mayara Secco Torres Silva, Ever Arturo Corral Herrera, Brenda Crabtree-Ramirez, José Luis Blanco, Nicolo Girometti, Valentina Mazzotta, Aniruddha Hazra, Macarena Silva, Juan José Montenegro-Idrogo, Kelly Gebo, Jade Ghosn, María Fernanda Peña Vázquez, Eduardo Matos Prado, Uche Unigwe, Judit Villar-García, Noah Wald-Dickler, Jason Zucker, Roger Paredes, Alexandra Calmy, Laura Waters, Cristina Galvan-Casas, Sharon Walmsley, Chloe M Orkin, SHARE-NET writing (...) Lancet
  A severe necrotising form of mpox in the context of advanced immunosuppression appears to behave like an AIDS-defining condition, with a high prevalence of fulminant dermatological and systemic manifestations and death. (The Lancet 401, 10380 (2023))
• 00:30
  [Comment] Medicine Unboxed 2023: Matter—what is your substance, whereof are you made? - Sam Guglani Lancet
  A line of poetry lasts some 3 seconds, according to the poet Don Paterson. He calls this “the length of the human moment”.1 I love the idea of it, paper and words amounting to time and consciousness. And I think of it now typing the lines of a sonnet that opened the first Medicine Unboxed event: (...) (The Lancet 401, 10379 (2023))

18 February

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Perspectives] Legacies of eugenics - Delan Devakumar, Rochelle Burgess Lancet
  We write this review as academics based in University College London (UCL), UK—a university with a chequered history of providing the scientific justification for the practice of eugenics, as highlighted in the Inquiry into the History of Eugenics at UCL—Final Report. Ours is a university from (...) (The Lancet 401, 10378 (2023))
• 00:00
  [Editorial] Responding to the Türkiye–Syria earthquake: what will it take? - The Lancet Lancet
  “Such things have always happened. It's part of destiny's plan.” The reaction of Recep Tayyip Erdo?an, Türkiye's President, to the devastating earthquakes that struck Türkiye and Syria on Feb 6, betrays a dangerous sense of fatalism, if not an active effort to deflect responsibility. As of Feb 14, (...) (The Lancet 401, 10376 (2023))
• 00:00
  [Comment] Offline: What are universities for? - Richard Horton Lancet
  Some years ago, I was privileged to join the council of a UK research-intensive university. Among the papers circulated before each meeting was an appendix listing the grants won by university faculty. The order of departments and individuals was governed by the size of the grant. Medicine (...) (The Lancet 401, 10376 (2023))
• 00:00
  [World Report] Turkish health workers speak out on earthquake - Kaya Genc Lancet
  Doctors have told The Lancet of the health impacts of, and inadequate preparation for, the earthquake which has killed more than 33 000 people. Kaya Genc reports from Istanbul. (The Lancet 401, 10376 (2023))
• 00:00
  [World Report] Warnings over potential collapse of Chilean health system - Mat Youkee Lancet
  A judicial ruling could cause the collapse of the private health sector, with devastating effects on the public health system. Mat Youkee reports from Santiago. (The Lancet 401, 10376 (2023))
• 00:00
  [World Report] Poland bans energy drinks for under 18s - Ed Holt Lancet
  The ban has been welcomed by physicians, who have seen the adverse health effects. Ed Holt reports. (The Lancet 401, 10376 (2023))
• 00:00
  [World Report] Development issues driving violent extremism - John Zarocostas Lancet
  The UN Development Programme calls for a shift to prevention of violent extremism in Africa. John Zarocostas reports from Geneva. (The Lancet 401, 10376 (2023))
• 00:00
  [Obituary] Luis Cuevas - Andrew Green Lancet
  Epidemiologist and expert in infectious diseases and diagnostics. Born in Guatemala City, Guatemala, on July 29, 1956, he died of pancreatic cancer on Jan 2, 2023 in Wirral, UK, aged 66 years. (The Lancet 401, 10376 (2023))
• 00:00
  [Correspondence] Afghanistan's health system is under duress, but has not collapsed - Christopher T Andersen, Mohamed Ag Ayoya, Dapeng Luo, Hadia Samaha, Fouzia Shafique, Mickey Chopra Lancet
  Afghanistan's political crisis in August, 2021 triggered economic turmoil and a humanitarian emergency. Widespread hunger threatens the lives of children.1 Media stories relay the dire situation of some medical facilities—mostly hospitals in Kabul and other urban centres—without funds for staff (...) (The Lancet 401, 10376 (2023))
• 00:00
  [Correspondence] A systematic analysis points in the wrong direction for cervical cancer elimination - Ashley Jackson Lancet
  In August, 2022, the GBD 2019 Cancer Risk Factors Collaborators published a systematic analysis that identified unsafe sex as the second leading risk factor for cancer in women globally.1 This finding was driven by data on cervical cancer, which is linked to persistent infection with high-risk (...) (The Lancet 401, 10376 (2023))
• 00:00
  [Correspondence] A systematic analysis points in the wrong direction for cervical cancer elimination – Author's reply - Christopher J L Murray, GBD 2019 Cancer Risk Factors Collaborators Lancet
  In their Correspondence, Ashley Jackson raises concern about the inclusion of unsafe sex as a behavioural, potentially modifiable risk factor for cervical cancer in the Global Burden of Disease (GBD) 2019 Study1 and the potential negative implications this framing could have on misdirecting (...) (The Lancet 401, 10376 (2023))
• 00:00
  [Correspondence] Cautionary tales from the UK for the health reform in Singapore - Jose M Valderas, Anna Stavdal, Kara Hanson, Yik Ying Teo, Yap Seng Chong, John E L Wong, Helena Legido-Quigley Lancet
  The 2022 White Paper on Healthier Singapore1 provides an ambitious reorientation of the health system towards population health to overcome its fragmentation and respond to its rapidly ageing population.2 The plan is well aligned with the renewed vision of WHO3 regarding primary health care in (...) (The Lancet 401, 10376 (2023))
• 00:00
  [Department of Error] Department of Error Lancet
  Hurvitz SA, Hegg R, Chung W-P, et al Trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer: updated results from DESTINY-Breast03, a randomised, open-label, phase 3 trial. Lancet 2023; 401: 105–17—In figure 1 of this Article, the number at (...) (The Lancet 401, 10376 (2023))
• 00:00
  [Clinical Picture] Differentiating activated Langerhans cells and dendritic melanocytes using reflectance confocal microscopy: the limitations of diagnosing melanoma in vivo - Lilia Correa-Selm, Katharine L Hanlon, James M Grichnik Lancet
  A 62-year-old man was referred to our clinic with a dark, atypical-looking lesion on his upper arm because the medical oncologists were concerned that it was possibly an early melanoma (appendix). (The Lancet 401, 10376 (2023))

17 February

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] COVID-19 infection, reinfection, and the transition to endemicity - Cheryl Cohen, Juliet Pulliam Lancet
  Understanding the protection conferred by previous infection against repeat infection, illness, and severe disease is key to projecting the future epidemiology of COVID-19 and to guiding vaccine policy decisions. In The Lancet, The COVID-19 Forecasting Team1 report data from a systematic review (...) (The Lancet 401, 10379 (2023))
• 00:30
  [Articles] Past SARS-CoV-2 infection protection against re-infection: a systematic review and meta-analysis - COVID-19 Forecasting Team Lancet
  Protection from past infection against re-infection from pre-omicron variants was very high and remained high even after 40 weeks. Protection was substantially lower for the omicron BA.1 variant and declined more rapidly over time than protection against previous variants. Protection from (...) (The Lancet 401, 10379 (2023))
• 00:30
  [Correspondence] Addressing the effects of the earthquakes on Türkiye's health-care system - Olivier Uwishema Lancet
  On Feb 6, 2023, a 7·8 magnitude earthquake hit Türkiye and Syria. This was followed by numerous aftershocks and a second earthquake of 7·6 magnitude.1 These earthquakes were the deadliest to hit Türkiye since 1999, when a similar magnitude tremor devastated the densely populated eastern Marmara Sea (...) (The Lancet 401, 10378 (2023))
• 00:30
  [Comment] Reclaiming global health - Liam Smeeth, Catherine Kyobutungi Lancet
  In a widely cited consensus statement from 2009, global health was defined as “an area for study, research, and practice that places a priority on improving health and achieving equity in health for all people worldwide”.1 This is a laudable intention. However, global health has increasingly come (...) (The Lancet 401, 10377 (2023))

16 February

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Correspondence] CD19-targeted CAR T cells in refractory antisynthetase syndrome - Fabian Müller, Sebastian Boeltz, Johannes Knitza, Michael Aigner, Simon Völkl, Soraya Kharboutli, Hannah Reimann, Jule Taubmann, Sascha Kretschmann, Wolf Rösler, Bernhard Manger, Jochen Wacker, Dimitrios Mougiakakos, Samir Jabari, Rolf Schröder, Michael Uder, Frank Roemer, Gerhard Krönke, Andreas Mackensen, Georg Schett Lancet
  Idiopathic inflammatory myopathies are a group of rare, immune-mediated diseases that primarily affect the skeletal muscle but can also involve other organs such as the lungs, skin, and joints.1 Antisynthetase syndrome comprises a major cluster of such diseases and is characterised by the (...) (The Lancet 401, 10379 (2023))

11 February

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] The therapeutic potential of psychedelics: the European regulatory perspective - Florence Butlen-Ducuing, Drummond E-Wen McCulloch, Marion Haberkamp, Taina Mattila, Ewa Ba?kowiec-Iskra, Georgios Aislaitner, Pavel Balabanov, Johan Lundberg, Dea Siggaard Stenbæk, Andre Elferink, Gitte M Knudsen, Steffen Thirstrup Lancet
  In the EU, mental health problems affect more than one in six people with considerable impacts for individuals and society and economic costs that exceed 4% of gross domestic product across the EU.1,2 There is a need for effective, safe new treatments for mental disorders. In the past decade (...) (The Lancet 401, 10378 (2023))
• 00:00
  [Comment] New medications to mitigate attacks of hereditary angioedema: does one size fit all? - Avner Reshef, Anete S Grumach Lancet
  Hereditary angioedema has received renewed attention in the past two decades, with the elucidation of the biochemical pathways resulting in bradykinin overproduction in patients with congenital C1esterase inhibitor (C1INH) deficiency, leading to recurrent attacks of tissue swelling due to (...) (The Lancet 401, 10375 (2023))
• 00:00
  [Comment] Offline: Why we must make peace with China - Richard Horton Lancet
  The Chinese Government's decision to float a surveillance balloon over US territory was a surprising violation of American sovereignty. China has issued a statement of regret, describing the incursion as an “accident”. The immediate impact was an abrupt postponement of US Secretary of State (...) (The Lancet 401, 10375 (2023))
• 00:00
  [World Report] US plan to shield science from “inappropriate influence” - Susan Jaffe Lancet
  The Biden administration is launching a new initiative on scientific integrity in federal agencies following multiple lapses. Susan Jaffe reports from Washington, DC. (The Lancet 401, 10375 (2023))
• 00:00
  [World Report] Health situation deteriorating in Kenyan refugee camp - Sharmila Devi Lancet
  Aid agencies have sounded warnings as conflict and drought drive people to Dadaab refugee complex. Sharmila Devi reports. (The Lancet 401, 10375 (2023))
• 00:00
  [Perspectives] Love in the face of death - Rachel Clarke Lancet
  According to literary legend, Ernest Hemingway was once challenged to write a short story using only six words. The resulting miniature masterpiece read: “For sale. Baby shoes. Never worn.” Medicine, I believe, has its own combination of words unparalleled for fusing sorrow with brevity. They (...) (The Lancet 401, 10375 (2023))
• 00:00
  [Perspectives] A waiting crisis? - Laura Salisbury, Lisa Baraitser, Jocelyn Catty, Kelechi Anucha, Stephanie Davies, Michael J Flexer, Martin D Moore, Jordan Osserman Lancet
  It is a repeated refrain across UK news: waiting times for health care in the National Health Service (NHS) have reached crisis levels. Millions of patients are waiting for elective surgery and potentially hundreds of people could be dying each week due to excessive waits for ambulances and (...) (The Lancet 401, 10375 (2023))
• 00:00
  [Obituary] Sir Michael David Rawlins - Geoff Watts Lancet
  Clinical pharmacologist and founding Chair of NICE. He was born in Shrewsbury, UK, on March 28, 1941 and died in Darlington, UK, from sepsis and heart failure on Jan 1, 2023 aged 81 years. (The Lancet 401, 10375 (2023))
• 00:00
  [Correspondence] Conflicting COVID-19 excess mortality estimates - Matshidiso Moeti, Lindiwe Makubalo, Abdou Salam Gueye, Thierno Balde, Humphrey Karamagi, Gordon Awandare, S M Thumbi, Feifei Zhang, Francisca Mutapi, Mark Woolhouse Lancet
  A study1 by the COVID-19 Excess Mortality Collaborators estimates more than 18 million COVID-19 deaths globally by the end of 2021—three times those reported. The COVID-19 Excess Mortality Collaborators claim that under-ascertainment is especially severe in sub-Saharan Africa, with actual deaths (...) (The Lancet 401, 10375 (2023))
• 00:00
  [Correspondence] Conflicting COVID-19 excess mortality estimates - Desmond O'Neill Lancet
  Although the global review of excess deaths from the COVID-19 pandemic might seem to give authorities in some countries encouragement for their policies,1 it seems unfortunate that a key vulnerable group was missing from discussion in the (...) (The Lancet 401, 10375 (2023))
• 00:00
  [Correspondence] Conflicting COVID-19 excess mortality estimates - Jonas Schöley, Ariel Karlinsky, Dmitry Kobak, Charles Tallack Lancet
  To estimate the COVID-19 death toll, the COVID-19 Excess Mortality Collaborators1 have presented excess mortality estimates for 2020–21 for all countries in the world. We argue that for many countries, these estimates are implausible because they imply an unrealistic number of expected deaths, (...) (The Lancet 401, 10375 (2023))
• 00:00
  [Correspondence] Conflicting COVID-19 excess mortality estimates - Alberto Donzelli Lancet
  The COVID-19 Excess Mortality Collaborators concluded that “The full impact of the pandemic has been much greater than what is indicated by reported deaths due to COVID-19 alone”. They estimate that 18·2 million (95% CI 17·1–19·6) people died worldwide because of the pandemic (as measured by excess (...) (The Lancet 401, 10375 (2023))
• 00:00
  [Correspondence] Conflicting COVID-19 excess mortality estimates - Peter Bager, Jens Nielsen, Samir Bhatt, Lise Birk Nielsen, Tyra Grove Krause, Lasse Skafte Vestergaard, The EuroMOMO Network Lancet
  Excess mortality is an important metric summarising COVID-19 disease burden, informing public health policy and future preparedness needs.1 However, separating the deaths that occurred from COVID-19 versus those from all other causes is challenging. Essentially, the unknowns are the (...) (The Lancet 401, 10375 (2023))
• 00:00
  [Correspondence] Conflicting COVID-19 excess mortality estimates – Authors' reply - Simon I Hay, Christopher J L Murray, COVID-19 Excess Mortality Collaborators Lancet
  The COVID-19 pandemic has caused almost 8 million reported deaths worldwide since late 2019.1 Although this is a staggering loss of human lives, 8 million is a vast under-estimation of the true toll of the pandemic. In addition to under-reporting and misclassification of COVID-19 deaths, the (...) (The Lancet 401, 10375 (2023))
• 00:00
  [Department of Error] Department of Error Lancet
  Forrest IS, Petrazzini BO, Duffyet Á, et al.Machine learning-based marker for coronary artery disease:derivation and validation in twolongitudinal cohorts. Lancet 2023; 401: 215–25—The codes for the CAD case definition in the appendix have been updated. The appendix of this Article has been (...) (The Lancet 401, 10375 (2023))
• 00:00
  [Department of Error] Department of Error Lancet
  Samarasekera U. Lynette Denny: women's cancer researcher with global impact. Lancet 2023; 401: 261—In this Profile, HPV-negative has been corrected to HIV-negative in the sixth sentence of the second paragraph. The online version has been corrected as of Feb 9, (...) (The Lancet 401, 10375 (2023))
• 00:00
  [Articles] An investigational oral plasma kallikrein inhibitor for on-demand treatment of hereditary angioedema: a two-part, randomised, double-blind, placebo-controlled, crossover phase 2 trial - Emel Aygören-Pürsün, Andrea Zanichelli, Danny M Cohn, Mauro Cancian, Roman Hakl, Tamar Kinaciyan, Markus Magerl, Inmaculada Martinez-Saguer, Marcin Stobiecki, Henriette Farkas, Sorena Kiani-Alikhan, Vesna Grivcheva-Panovska, Jonathan A Bernstein, H Henry Li, Hilary J Longhurst, Paul K Audhya, Michael D Smith, Christopher M Yea, Andreas Maetzel, Daniel K Lee, Edward P Feener, Richard Gower, William R Lumry, Aleena Banerji, Marc A Riedl, Marcus Maurer Lancet
  Oral administration of sebetralstat was well tolerated and led to rapid suppression of plasma kallikrein activity, resulting in increased time to use of conventional attack treatment and faster symptom relief versus placebo. Based on these results, a phase 3 trial to evaluate the efficacy and (...) (The Lancet 401, 10375 (2023))
• 00:00
  [Clinical Picture] A diagnostic conundrum of a “ring of fire”: a case of tuberculous perimyocarditis - Nikoo Aziminia, Biji Soman, Jose Samoes, Rabinder Randhawa, Julian O M Ormerod, Attila Kardos Lancet
  A 36-year-old man presented to our hospital with a 2-week history of palpitations in the context of 3 months of a dry cough, weight loss, and night sweats. (The Lancet 401, 10375 (2023))

10 February

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Adjuvant ipilimumab and nivolumab in renal cell carcinoma: more questions than answers - Ursula Maria Vogl, David McDermott, Thomas Powles Lancet
  Immune checkpoint inhibitors, such as pembrolizumab (a PD-1 inhibitor), nivolumab (a PD-1 inhibitor), and ipilimumab (a CTLA-4 inhibitor), are widely used in patients with clear cell renal cell carcinoma.1 Single-agent PD-1 inhibitors, such as pembrolizumab or nivolumab, have activity in (...) (The Lancet 401, 10379 (2023))
• 00:30
  [Articles] Adjuvant nivolumab plus ipilimumab versus placebo for localised renal cell carcinoma after nephrectomy (CheckMate 914): a double-blind, randomised, phase 3 trial - Robert J Motzer, Paul Russo, Viktor Grünwald, Yoshihiko Tomita, Bogdan Zurawski, Omi Parikh, Sebastiano Buti, Philippe Barthélémy, Jeffrey C Goh, Dingwei Ye, Alejo Lingua, Jean-Baptiste Lattouf, Laurence Albigès, Saby George, Brian Shuch, Jeffrey Sosman, Michael Staehler, Sergio Vázquez Estévez, Burcin Simsek, Julia Spiridigliozzi, Aleksander Chudnovsky, Axel Bex Lancet
  Adjuvant therapy with nivolumab plus ipilimumab did not improve disease-free survival versus placebo in patients with localised renal cell carcinoma at high risk of recurrence after nephrectomy. Our study results do not support this regimen for the adjuvant treatment of renal cell (...) (The Lancet 401, 10379 (2023))
• 00:30
  [Comment] The end of the beginning: progress and next steps in KRAS-mutant non-small-cell lung cancer - Sarah B Goldberg, Roy S Herbst Lancet
  One of the most significant breakthroughs in oncology in recent years is the ability to target KRAS. KRAS is the most commonly mutated oncogene in human cancer, with greatest frequency in non-small-cell lung cancer (NSCLC), colorectal cancer, and pancreatic cancer. Since the gene's discovery (...) (The Lancet 401, 10378 (2023))

9 February

Lancet https://www.thelancet.com/journals/lancet

• 19:18
  [Comment] Tenecteplase use in patients with acute ischaemic stroke - Bijoy K Menon, Nishita Singh, P N Sylaja Lancet
  Physicians have always faced uncertainty when making clinical decisions.1 Clinical research seeks to reduce such uncertainty by generating more evidence. The more evidence that supports a treatment, the less uncertainty there is around its use.2 The highest quality of evidence comes from large (...) (The Lancet 401, 10377 (2023))
• 19:18
  [Articles] Tenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial - Yongjun Wang, Shuya Li, Yuesong Pan, Hao Li, Mark W Parsons, Bruce C V Campbell, Lee H Schwamm, Marc Fisher, Fengyuan Che, Hongguo Dai, Deyang Li, Runhui Li, Junhai Wang, Yilong Wang, Xingquan Zhao, Zixiao Li, Huaguang Zheng, Yunyun Xiong, Xia Meng, TRACE-2 Investigators Lancet
  Tenecteplase was non-inferior to alteplase in people with ischaemic stroke who were eligible for standard intravenous thrombolytic but ineligible for or refused endovascular thrombectomy. (The Lancet 401, 10377 (2023))
• 00:30
  [Comment] Expression of concern: Clinical transplantation of a tissue-engineered airway - The Editors of The Lancet Lancet
  The Lancet has received continuing questions over the reliability of the findings and conduct of this reported case,1 since Paolo Macchiarini was found guilty of scientific misconduct in 2018.2 After an investigation by the head of the institution in Barcelona, Spain, where the patient was (...) (The Lancet 401, 10376 (2023))
• 00:30
  [Comment] Expression of concern: The first tissue-engineered airway transplantation: 5-year follow-up results - The Editors of The Lancet Lancet
  As with the Expression of Concern1 for the original description of this case,2 given that continuing concerns have persisted over a long time, the Committee on Publication Ethics has also recommended that The Lancet issue an Expression of Concern for this Article.3 We are following this (...) (The Lancet 401, 10376 (2023))

8 February

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Articles] Sotorasib versus docetaxel for previously treated non-small-cell lung cancer with KRASG12C mutation: a randomised, open-label, phase 3 trial - Adrianus Johannes de Langen, Melissa L Johnson, Julien Mazieres, Anne-Marie C Dingemans, Giannis Mountzios, Miklos Pless, Jürgen Wolf, Martin Schuler, Hervé Lena, Ferdinandos Skoulidis, Yasuto Yoneshima, Sang-We Kim, Helena Linardou, Silvia Novello, Anthonie J van der Wekken, Yuanbin Chen, Solange Peters, Enriqueta Felip, Benjamin J Solomon, Suresh S. Ramalingam, Christophe Dooms, Colin R Lindsay, Carlos Gil Ferreira, Normand Blais, Cynthia C Obiozor, Yang Wang, Bhakti Mehta, Tracy Varrieur, Gataree Ngarmchamnanrith, Björn Stollenwerk, David Waterhouse, Luis Paz-Ares, CodeBreaK 200 (...) Lancet
  Sotorasib significantly increased progression-free survival and had a more favourable safety profile, compared with docetaxel, in patients with advanced NSCLC with the KRASG12C mutation and who had been previously treated with other anticancer (...) (The Lancet 401, 10378 (2023))
• 15:24
  [Comment] So far, no novel SARS-CoV-2 variants from Beijing—and hopefully better scientific cooperation going forward - Wolfgang Preiser, Tongai Maponga Lancet
  In early December, 2022, China abandoned what until then had been among the most stringent policies against the COVID-19 pandemic globally.1 Termed the “dynamic zero-COVID policy”, mass testing, strict quarantine protocols, and movement controls had aimed to bring COVID-19 outbreaks under control (...) (The Lancet 401, 10377 (2023))
• 15:22
  [Articles] Characterisation of SARS-CoV-2 variants in Beijing during 2022: an epidemiological and phylogenetic analysis - Yang Pan, Liang Wang, Zhaomin Feng, Hui Xu, Fu Li, Ying Shen, Daitao Zhang, William J Liu, George F Gao, Quanyi Wang Lancet
  The co-circulation of BF.7 and BA.5.2 has been present in the current outbreak since Nov 14, 2022 in Beijing, and there is no evidence that novel variants emerged. Although our data were only from Beijing, the results could be considered a snapshot of China, due to the frequent population (...) (The Lancet 401, 10377 (2023))
• 00:30
  [Editorial] Unveiling the predatory tactics of the formula milk industry - The Lancet Lancet
  For decades, the commercial milk formula (CMF) industry has used underhand marketing strategies, designed to prey on parents' fears and concerns at a vulnerable time, to turn the feeding of young children into a multibillion-dollar business. The immense economic power accrued by CMF (...) (The Lancet 401, 10375 (2023))
• 00:30
  [Comment] Stemming commercial milk formula marketing: now is the time for radical transformation to build resilience for breastfeeding - Tanya Doherty, Christiane Horwood, Catherine Pereira-Kotze, Lisanne du Plessis, Chantell Witten Lancet
  One of the striking messages of the Lancet Breastfeeding Series1–3 is that the consumption of commercial milk formula (CMF) by infants and young children has been normalised. More children are consuming CMF than ever before.2 Only 48% of the world's infants and young children are breastfed as (...) (The Lancet 401, 10375 (2023))
• 00:30
  [Series] Breastfeeding: crucially important, but increasingly challenged in a market-driven world - Rafael Pérez-Escamilla, Cecília Tomori, Sonia Hernández-Cordero, Phillip Baker, Aluisio J D Barros, France Bégin, Donna J Chapman, Laurence M Grummer-Strawn, David McCoy, Purnima Menon, Paulo Augusto Ribeiro Neves, Ellen Piwoz, Nigel Rollins, Cesar G Victora, Linda Richter, 2023 Lancet Breastfeeding Series Group Lancet
  In this Series paper, we examine how mother and baby attributes at the individual level interact with breastfeeding determinants at other levels, how these interactions drive breastfeeding outcomes, and what policies and interventions are necessary to achieve optimal breastfeeding. About one in (...) (The Lancet 401, 10375 (2023))
• 00:30
  [Series] Marketing of commercial milk formula: a system to capture parents, communities, science, and policy - Nigel Rollins, Ellen Piwoz, Phillip Baker, Gillian Kingston, Kopano Matlwa Mabaso, David McCoy, Paulo Augusto Ribeiro Neves, Rafael Pérez-Escamilla, Linda Richter, Katheryn Russ, Gita Sen, Cecília Tomori, Cesar G Victora, Paul Zambrano, Gerard Hastings, 2023 Lancet Breastfeeding Series Group Lancet
  Despite proven benefits, less than half of infants and young children globally are breastfed in accordance with the recommendations of WHO. In comparison, commercial milk formula (CMF) sales have increased to about US$55 billion annually, with more infants and young children receiving formula (...) (The Lancet 401, 10375 (2023))
• 00:30
  [Series] The political economy of infant and young child feeding: confronting corporate power, overcoming structural barriers, and accelerating progress - Phillip Baker, Julie P Smith, Amandine Garde, Laurence M Grummer-Strawn, Benjamin Wood, Gita Sen, Gerard Hastings, Rafael Pérez-Escamilla, Chee Yoke Ling, Nigel Rollins, David McCoy, 2023 Lancet Breastfeeding Series Group Lancet
  Despite increasing evidence about the value and importance of breastfeeding, less than half of the world's infants and young children (aged 0–36 months) are breastfed as recommended. This Series paper examines the social, political, and economic reasons for this problem. First, this paper (...) (The Lancet 401, 10375 (2023))

4 February

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Articles] Secukinumab in moderate-to-severe hidradenitis suppurativa (SUNSHINE and SUNRISE): week 16 and week 52 results of two identical, multicentre, randomised, placebo-controlled, double-blind phase 3 trials - Alexa B Kimball, Gregor B E Jemec, Afsaneh Alavi, Ziad Reguiai, Alice B Gottlieb, Falk G Bechara, Carle Paul, Evangelos J Giamarellos Bourboulis, Axel P Villani, Andreas Schwinn, Franziska Ruëff, Larisha Pillay Ramaya, Adam Reich, Ines Lobo, Rodney Sinclair, Thierry Passeron, Antonio Martorell, Pedro Mendes-Bastos, Georgios Kokolakis, Pierre-Andre Becherel, Magdalena B Wozniak, Angela Llobet Martinez, Xiaoling Wei, Lorenz Uhlmann, Anna Passera, Deborah Keefe, Ruvie Martin, Clarice Field, Li Chen, Marc Vandemeulebroecke, Shoba Ravichandran, Elisa (...) Lancet
  When given every 2 weeks, secukinumab was clinically effective at rapidly improving signs and symptoms of hidradenitis suppurativa with a favourable safety profile and with sustained response up to 52 weeks of treatment. (The Lancet 401, 10378 (2023))
• 00:30
  [Comment] The optimal biologic treatment target for hidradenitis suppurativa remains undiscovered - Alexander Egeberg, Jacob P Thyssen Lancet
  Hidradenitis suppurativa is a chronic inflammatory skin disease affecting the hair follicles that reside in axillary, inguinal, and submammary folds. Although hidradenitis suppurativa was considered a disorder of primary follicular occlusion, it is increasingly considered to be primarily (...) (The Lancet 401, 10378 (2023))
• 00:00
  [Editorial] Global cancer: overcoming the narrative of despondency - The Lancet Lancet
  It is easy to become despondent about global cancer. Feb 4 marks World Cancer Day, and renewed calls to “close the cancer care gap”. But the worldwide inequities in cancer care and control are deeply rooted. The facts are stark. Childhood cancer survival rates, for example, are more than 80% in (...) (The Lancet 401, 10374 (2023))
• 00:00
  [Comment] Clinical use of pre-emptive pharmacogenetic programmes - Eva Peñas-LLedó, Adrián LLerena Lancet
  The clinical implementation of pharmacogenetics (the study of how genetics influence individual variations in drug response) is a key factor in the development of programmes to prevent adverse drug reactions. Yet pharmacogenetics testing in clinics is still infrequent and is mainly reactive and (...) (The Lancet 401, 10374 (2023))
• 00:00
  [Comment] Thank you to The Lancet's reviewers in 2022 - The Editors of The Lancet Lancet
  Over The Lancet's 200-year history, we are privileged to have witnessed a great number of advances that have underpinned the development of modern medicine. With the COVID-19 pandemic still weighing heavily on clinicians and health services around the world, we extend our sincere gratitude to (...) (The Lancet 401, 10374 (2023))
• 00:00
  [Comment] Offline: Strange fruit - Richard Horton Lancet
  For a fleeting moment, guns re-entered the Oval Office. US President Joe Biden called for a federal ban on assault weapons. His plea, ignored, came after 11 people were killed in a Los Angeles ballroom dance studio and seven people were shot down in California's Half Moon Bay, near San (...) (The Lancet 401, 10374 (2023))
• 00:00
  [Comment] Thank you to The Lancet statistical and peer reviewers in 2022 - The Lancet Editors Lancet
  Frank Aarestrup (The Lancet 401, 10374 (2023))
• 00:00
  [World Report] How to fix the NHS - Udani Samarasekera Lancet
  Staff are striking while patients face long delays for care. Udani Samarasekera asks what it will take to repair a broken NHS. (The Lancet 401, 10374 (2023))
• 00:00
  [World Report] Turkish doctors warn of government persecution - Kaya Genç Lancet
  Medics have criticised the government for launching a series of legal challenges against the Turkish Medical Association. Kaya Genç reports from Istanbul. (The Lancet 401, 10374 (2023))
• 00:00
  [Perspectives] Chelsea Watego: foregrounding Indigenous intellectual sovereignty - Aarathi Prasad Lancet
  Chelsea Watego is Professor of Indigenous Health and the Executive Director of the Carumba Institute at Queensland University of Technology in Brisbane, QLD, Australia. Her studies, which are “trying to shine a light on the structural dimension of race and its role in the production of health (...) (The Lancet 401, 10374 (2023))
• 00:00
  [Perspectives] A space to grow - Rageshri Dhairyawan Lancet
  A woman's right to choose what happens to her body is an issue that often makes headlines. In 2022, the US Supreme Court made the controversial decision to overturn Roe v Wade, the 1973 law which made access to safe abortion a constitutional right. Concerns were also raised by human rights (...) (The Lancet 401, 10374 (2023))
• 00:00
  [Perspectives] The kindness of strangers - Marco De Ambrogi Lancet
  “I don’t want realism. I want magic.” These legendary words capture the state of mind of Blanche DuBois, the central character of Tennessee Williams’ play A Streetcar Named Desire. Partly inspired by Williams’ sister, whose mental ill health led her to be institutionalised and to have a lobotomy, (...) (The Lancet 401, 10374 (2023))
• 00:00
  [Perspectives] When dignity meets evidence - Seye Abimbola Lancet
  We are all entitled to dignity because we possess certain ethically important features. One of those human features is that we are knowers. We know things. We learn. We make sense of what we know. We interpret our realities and the systems within which we have our being. If this feature is not (...) (The Lancet 401, 10374 (2023))
• 00:00
  [Obituary] Audrey Evans - Andrew Green Lancet
  Paediatric oncologist. Born March 6, 1925 in York, UK, she died on Sept 29, 2022 in Philadelphia, PA, USA, aged 97 years. (The Lancet 401, 10374 (2023))
• 00:00
  [Correspondence] Health literacy exists beyond the boundaries of medicine - Kristina Jenei Lancet
  The Editorial1 asks important questions about how individuals can make healthy decisions in an increasingly complex world that is overwhelmed with false information. Although these questions remain important for future research, past thinkers might offer relevant (...) (The Lancet 401, 10374 (2023))
• 00:00
  [Correspondence] Co-design effective health-literacy videos - Vicki Kerrigan, Deanna Park, Cheryl Ross, Jane Davies, Anna P Ralph Lancet
  The Editorial1 emphasises the need for health literacy interventions to be co-designed with end users and community organisations beyond medicine. (The Lancet 401, 10374 (2023))
• 00:00
  [Correspondence] Health-literacy education drives empowerment and agency - Leena Paakkari, Elizabeth Balch-Crystal, Mari Manu, Jenni Ruotsalainen, Jenni Salminen, Emmi Ulvinen, Minna Torppa Lancet
  The Editorial1 on health literacy presents needful perspectives. However, two further aspects related to health literacy should be emphasised: the importance of sustained support for epistemic empowerment and the role of children's and adolescents’ own agency in effecting change in their (...) (The Lancet 401, 10374 (2023))
• 00:00
  [Correspondence] The urgent need to address health literacy in schools - Orkan Okan, Leena Paakkari, Didier Jourdan, Vivian Barnekow, Martin W Weber Lancet
  The Editorial1 raised an important question: why is health literacy failing so many? It urgently called for effective responses to support people to better manage health information, but also to account for the environmental and social forces that shape people's choices. Overcoming the (...) (The Lancet 401, 10374 (2023))
• 00:00
  [Correspondence] China needs a scientific long COVID recovery-support platform - Hao Tan, Jiayan Liu, Fanrui Zeng Lancet
  Post-COVID-19 condition (also known as long COVID) emerged as a major public health problem in the post-pandemic era.1 Timely and sufficient information guidance and support are crucial for an effective response to long COVID. With China likely to end its zero-COVID strategy in the future,2,3 (...) (The Lancet 401, 10374 (2023))
• 00:00
  [Correspondence] Speed up multi-pathogen surveillance - Chengjun Li, Huan Zhong, Yuwei Xie, Tian Bai, Bing Yan, Christian Sonne Lancet
  Human health is facing escalating risks of circulating contagious pathogens and emerging zoonotic spillover due to global changes characterised by urbanisation and habitat fragmentation.1 The COVID-19 pandemic and 2022 mpox outbreaks have warned us of a possible harsh future, with further (...) (The Lancet 401, 10374 (2023))
• 00:00
  [Correspondence] Changing the mass casualty disaster surgical response - Hamaiyal Sana, Anam N Ehsan, Ali I Rae, Kavitha Ranganathan Lancet
  Over 33 million people were affected by the floods in Pakistan in 2022. Even though more than 650 000 pregnant women currently require obstetric services and there are over 13 000 victims of traumatic injury, surgical diseases have received little resources and coverage in relief efforts.1 (...) (The Lancet 401, 10374 (2023))
• 00:00
  [Articles] A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study - Jesse J Swen, Cathelijne H van der Wouden, Lisanne EN Manson, Heshu Abdullah-Koolmees, Kathrin Blagec, Tanja Blagus, Stefan Böhringer, Anne Cambon-Thomsen, Erika Cecchin, Ka-Chun Cheung, Vera HM Deneer, Mathilde Dupui, Magnus Ingelman-Sundberg, Siv Jonsson, Candace Joefield-Roka, Katja S Just, Mats O Karlsson, Lidija Konta, Rudolf Koopmann, Marjolein Kriek, Thorsten Lehr, Christina Mitropoulou, Emmanuelle Rial-Sebbag, Victoria Rollinson, Rossana Roncato, Matthias Samwald, Elke Schaeffeler, Maria Skokou, Matthias Schwab, Daniela Steinberger, Julia C Stingl, Roman Tremmel, Richard M Turner, (...) Lancet
  Genotype-guided treatment using a 12-gene pharmacogenetic panel significantly reduced the incidence of clinically relevant adverse drug reactions and was feasible across diverse European health-care system organisations and settings. Large-scale implementation could help to make drug therapy (...) (The Lancet 401, 10374 (2023))

3 February

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [World Report] Anger as UK drops health disparities plans - Jacqui Thornton Lancet
  The UK Government has admitted it is dropping its health disparities legislation, disappointing medical and health bodies. Jacqui Thornton reports. (The Lancet 401, 10375 (2023))

2 February

Lancet https://www.thelancet.com/journals/lancet

• 11:00
  [Articles] Cell-free fetal DNA for genetic evaluation in Copenhagen Pregnancy Loss Study (COPL): a prospective cohort study - Tanja Schlaikjær Hartwig, Louise Ambye, Jennifer R Gruhn, Jesper Friis Petersen, Tine Wrønding, Letizia Amato, Andrew Chi-Ho Chan, Boyang Ji, Maiken Hemme Bro-Jørgensen, Lene Werge, Mette Marie Babiel Schmidt Petersen, Clara Brinkmann, Julie Birch Petersen, Morten Dunø, Iben Bache, Markus J Herrgård, Finn Stener Jørgensen, Eva R Hoffmann, Henriette Svarre Nielsen, COPL consortium Lancet
  This validation of cffDNA-based testing in pregnancy loss shows the potential and feasibility of the method to distinguish euploid and aneuploid pregnancy loss for improved clinical management and benefit of future reproductive medicine and women's health (...) (The Lancet 401, 10378 (2023))
• 11:00
  [Comment] The use of cell-free DNA technology in pregnancy loss - Lorraine Dugoff Lancet
  Pregnancy loss is the most common pregnancy complication, occurring in up to 70% of fertilised eggs and approximately 15–20% of clinically recognised pregnancies.1 The causes of pregnancy loss can provide important information for medical management, reproductive counselling, and supportive (...) (The Lancet 401, 10378 (2023))
• 00:30
  [Comment] A fresh look at treatment for ectopic pregnancy - Sarita Sonalkar, Emma Gilmore Lancet
  Ectopic pregnancy is the implantation of a fertilised egg outside of the uterine body, most commonly in the fallopian tube, and is a serious medical condition carrying a risk of tubal rupture and resultant life-threatening haemorrhage. Ectopic pregnancy accounts for approximately 2% of all (...) (The Lancet 401, 10377 (2023))
• 00:30
  [Articles] Combination of gefitinib and methotrexate to treat tubal ectopic pregnancy (GEM3): a multicentre, randomised, double-blind, placebo-controlled trial - Andrew W Horne, Stephen Tong, Catherine A Moakes, Lee J Middleton, W Colin Duncan, Ben W Mol, Lucy H R Whitaker, Davor Jurkovic, Arri Coomarasamy, Natalie Nunes, Tom Holland, Fiona Clarke, Ann M Doust, Jane P Daniels, GEM3 collaborative Lancet
  In women with a tubal ectopic pregnancy, adding oral gefitinib to parenteral methotrexate does not offer clinical benefit over methotrexate and increases minor adverse reactions. (The Lancet 401, 10377 (2023))
• 00:30
  [Correspondence] Israel decides to cancel sweetened beverage tax in setback to public health - Aron M Troen, Ana Paula Bortoletto Martins, Ildefonso Hernandez Aguado, Barry Popkin, Dariush Mozaffarian, Martin Caraher, Amy Lazarus Yaroch, Miguel Ángel Royo Bordonada, Hagai Levine Lancet
  As members of the World Federation of Public Health Associations Non-Communicable Diseases Prevention & Health Promotion and Policy Working Groups, and other leading scholars of nutrition policy, health sciences, and economics, we would like to convey extreme concern over the Israeli (...) (The Lancet 401, 10376 (2023))

1 February

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Towards a world with no child marriage: four countries pledge action - Fazilatun Nessa Indira, Gisèle Ndaya Luseba, Ergogie Tesfaye, Pauline Kedem Tallen Lancet
  The marriage of a girl child is a violation of her rights and a threat to her ability to thrive. A married girl is usually not in school. She is vulnerable to early pregnancy, with its associated health risks.1 She undertakes caring responsibilities that are beyond those appropriate for her (...) (The Lancet 401, 10378 (2023))
• 00:30
  [Comment] Green and blue spaces: crucial for healthy, sustainable urban futures - Kristie L Ebi, Kathryn Bowen Lancet
  Scientific knowledge of the health benefits of urban green and blue spaces is not being translated fast enough into practical and policy changes. Such changes are needed to improve the liveability of communities in large urban areas and to address the dual and growing challenges of climate (...) (The Lancet 401, 10376 (2023))
• 00:30
  [Correspondence] Independent monitoring for the pandemic accord: a non-negotiable provision - Layth Hanbali, Susanna Lehtimaki, Elliot Hannon, Christine McNab, Nina Schwalbe Lancet
  In February, 2023 the Intergovernmental Negotiating Body for a pandemic accord will discuss a zero draft. The Intergovernmental Negotiating Body aims to present an accord for implementation by the World Health Assembly in May, (...) (The Lancet 401, 10376 (2023))
• 00:30
  [Articles] Cooling cities through urban green infrastructure: a health impact assessment of European cities - Tamara Iungman, Marta Cirach, Federica Marando, Evelise Pereira Barboza, Sasha Khomenko, Pierre Masselot, Marcos Quijal-Zamorano, Natalie Mueller, Antonio Gasparrini, José Urquiza, Mehdi Heris, Meelan Thondoo, Mark Nieuwenhuijsen Lancet
  Our results showed the deleterious effects of UHIs on mortality and highlighted the health benefits of increasing tree coverage to cool urban environments, which would also result in more sustainable and climate-resilient cities. (The Lancet 401, 10376 (2023))

31 January

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Perspectives] Jarbas Barbosa da Silva Jr: new Director of PAHO - Udani Samarasekera Lancet
  On Feb 1, 2023, Jarbas Barbosa da Silva Jr will succeed Carissa Etienne of Dominica as Director of the Pan American Health Organization (PAHO). Speaking to The Lancet ahead of his 5-year term, Barbosa outlined the “very complex epidemiological scenario” in the Americas, including the double (...) (The Lancet 401, 10375 (2023))

28 January

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Review] Malnutrition in older adults - Elsa Dent, Olivia R L Wright, Jean Woo, Emiel O Hoogendijk Lancet
  Malnutrition is a highly prevalent condition in older adults, and poses a substantial burden on health, social, and aged-care systems. Older adults are vulnerable to malnutrition due to age-related physiological decline, reduced access to nutritious food, and comorbidity. Clinical guidelines (...) (The Lancet 401, 10380 (2023))
• 00:00
  [Editorial] The NHS is sick, but it is treatable - The Lancet Lancet
  The NHS is 75 years old and is unwell. Patients with a suspected heart attack are waiting five times longer for an ambulance than the 18-min target. In 2022, 347 707 patients spent more than 12 h in Accident and Emergency departments waiting for a bed, four times as many as in the previous 10 (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Comment] Gaining MOMENTUM against anaemic myelofibrosis - Kazuhiko Ikeda, Koki Ueda Lancet
  Myelofibrosis is a progressive chronic myeloproliferative neoplasm driven by Janus kinase and signal transducer and activator of transcription (JAK–STAT) pathway activation, mostly due to mutations in JAK2, MPL, and CALR.1 Myelofibrosis arises de novo (primary myelofibrosis) or secondarily from (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Comment] Developing a vaccine against Marburg virus disease - Daniela Manno Lancet
  Marburg virus disease is a severe infection in people and non-human primates (NHPs), with a case-fatality rate of 23–90%.1 The disease is caused by the Marburg virus, a member of the Filoviridae family, which includes the viruses responsible for Ebola virus disease.1 Marburg virus disease is (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Comment] Offline: America—a codicil - Richard Horton Lancet
  Yes, the US will remain a dominant force in global health for the foreseeable future. But Shannon K O’Neil, in her provocative book The Globalization Myth, casts doubt on the sustainability of America's influence. First, the positive. The US is wealthy and has vastly skilled human resources to (...) (The Lancet 401, 10373 (2023))
• 00:00
  [World Report] New legislation to overhaul mental health care in Nigeria - Paul Adepoju Lancet
  A new mental health law is hoped to transform care for patients in Nigeria. Paul Adepoju reports from Ibadan, Nigeria. (The Lancet 401, 10373 (2023))
• 00:00
  [World Report] Mexico bans smoking in public - Sharmila Devi Lancet
  New legislation to curb the harms of tobacco is among the strongest in the world. Sharmila Devi reports. (The Lancet 401, 10373 (2023))
• 00:00
  [World Report] “Unfettered flow”: how ProMED-mail keeps the world alert - Talha Burki Lancet
  For almost 30 years, contributors to ProMED-mail have flagged new and emerging infectious threats to health. Talha Burki reports. (The Lancet 401, 10373 (2023))
• 00:00
  [Perspectives] Lynette Denny: women's cancer researcher with global impact - Udani Samarasekera Lancet
  As a young child in apartheid era South Africa, Lynette Denny saw police regularly raid the quarters of her family's domestic staff to find Black people who did not have the documents they were legally required to carry to prove their identity and employment. It left Denny with “a permanent (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Perspectives] Recruitmentology and the politics of consent in clinical research - Cameron Sabet, Simar S Bajaj, Fatima Cody Stanford Lancet
  Bearing the weight of a traumatic history, medical research is often seen as invasive and harmful by subaltern communities. The term subaltern, originating from postcolonial theory, refers to socio-politically silenced groups that are excluded from inner circles of colonial power. Western (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Obituary] Thomas Wilson Meade - Geoff Watts Lancet
  Epidemiologist and authority on thrombogenesis and heart disease. He was born in Oxford, UK, on Jan 21, 1936 and died of a lower respiratory tract infection in London, UK, on Oct 24, 2022 aged 86 years. (The Lancet 401, 10373 (2023))
• 00:00
  [Correspondence] Improving childhood cancer care in China - Yaping Wang, Jue Liu Lancet
  We read with interest Xin Ni and colleagues'1 study on cancer incidence, and the association between incidence and inaccessibility of health services among children and adolescents in China. The authors found that an estimated 121 145 cancer cases were diagnosed among children and adolescents (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Correspondence] Improving childhood cancer care in China – Authors' reply - Xin Ni, Zhe Li, Yingying Liu, Guoliang Bai, Xinping Li, Xiao Zhang Lancet
  We thank Yaping Wang and Jue Liu for their Correspondence in response to our Article1 about socioeconomic inequalities in cancer incidence and access to health services faced by Chinese children and adolescents. (The Lancet 401, 10373 (2023))
• 00:00
  [Correspondence] Medicine should be learned in a conducive environment - Sandro Vento Lancet
  Richard Horton argues that an academic health science system must possess societal goals and promote social cohesion and public trust.1 Indeed, medical education should help to promote better health outcomes for vulnerable populations and disadvantaged communities. However, to this end, it is (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Correspondence] Let research guide teaching in medical and public health - Arnaud Chiolero Lancet
  The pre-eminence of research over teaching in academic activity might be considered as an inheritance from the Enlightenment and, in the past few decades, from evidence-based medicine. Within this framework, teaching is secondary to research because the former is built, at least in part, on the (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Department of Error] Department of Error Lancet
  Schlaich MP, Bellet M, Weber MA, et al. Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial. Lancet 2022; 400: 1927–37—For this Article, the PRECISION investigators list has been updated. This correction (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Articles] Momelotinib versus danazol in symptomatic patients with anaemia and myelofibrosis (MOMENTUM): results from an international, double-blind, randomised, controlled, phase 3 study - Srdan Verstovsek, Aaron T Gerds, Alessandro M Vannucchi, Haifa Kathrin Al-Ali, David Lavie, Andrew T Kuykendall, Sebastian Grosicki, Alessandra Iurlo, Yeow Tee Goh, Mihaela C Lazaroiu, Miklos Egyed, Maria Laura Fox, Donal McLornan, Andrew Perkins, Sung-Soo Yoon, Vikas Gupta, Jean-Jacques Kiladjian, Nikki Granacher, Sung-Eun Lee, Luminita Ocroteala, Francesco Passamonti, Claire N Harrison, Barbara J Klencke, Sunhee Ro, Rafe Donahue, Jun Kawashima, Ruben Mesa, on behalf of MOMENTUM Study (...) Lancet
  Treatment with momelotinib, compared with danazol, resulted in clinically significant improvements in myelofibrosis-associated symptoms, anaemia measures, and spleen response, with favourable safety. These findings support the future use of momelotinib as an effective treatment in patients with (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Articles] Safety, tolerability, and immunogenicity of the chimpanzee adenovirus type 3-vectored Marburg virus (cAd3-Marburg) vaccine in healthy adults in the USA: a first-in-human, phase 1, open-label, dose-escalation trial - Melinda J Hamer, Katherine V Houser, Amelia R Hofstetter, Ana M Ortega-Villa, Christine Lee, Anne Preston, Brooke Augustine, Charla Andrews, Galina V Yamshchikov, Somia Hickman, Steven Schech, Jack N Hutter, Paul T Scott, Paige E Waterman, Mihret F Amare, Victoria Kioko, Casey Storme, Kayvon Modjarrad, Melanie D McCauley, Merlin L Robb, Martin R Gaudinski, Ingelise J Gordon, LaSonji A Holman, Alicia T Widge, Larisa Strom, Myra Happe, Josephine H Cox, Sandra Vazquez, Daphne A Stanley, Tamar Murray, Caitlyn N M Dulan, Ruth Hunegnaw, Sandeep R Narpala, Phillip A Swanson, Manjula Basappa, (...) Lancet
  This first-in-human trial of this cAd3-Marburg vaccine showed the agent is safe and immunogenic, with a safety profile similar to previously tested cAd3-vectored filovirus vaccines. 95% of participants produced a glycoprotein-specific antibody response at 4 weeks after a single vaccination, (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Clinical Picture] An imaging pitfall: misdiagnosis of pulmonary embolism in a patient with advanced cystic fibrosis and bronchiectasis - Michal Shteinberg, Sameer Kassem, Yochai Adir, Galit Livnat, Natalia Goldberg Lancet
  A 37-year-old woman presented to our emergency room reporting chest pain and palpitations which had woken her up in the early hours of the morning. She was known to be homozygous for a rare and severe form of cystic fibrosis with a mutation, described among Jewish people of Georgian descent, in (...) (The Lancet 401, 10373 (2023))

27 January

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Viewpoint] Deaths of despair and Indigenous data genocide - Joseph Friedman, Helena Hansen, Joseph P Gone Lancet
  The concept of deaths of despair—ie, mortality stemming from drug overdoses, suicide, and alcoholic liver disease—has emerged as a key notion for understanding US exceptionalism in mortality.1–3 From its origin, the framework was racialised, focused on disproportionate levels of midlife (age 45–54 (...) (The Lancet 401, 10379 (2023))
• 00:30
  [Comment] Health in global biodiversity governance: what is next? - Liz Willetts, Liane Comeau, Neil Vora, Ojistoh Horn, Marie Studer, Keith Martin, Melissa Lem, Claudel Pétrin-Desrosiers, Liz Grant, Kinari Webb Lancet
  The dependency of human health and wellbeing on nature is documented across disciplines, regions, cultures, and economies. Environmental degradation contributes substantially to the global burden of disease and concurrent global environmental changes are increasingly recognised as public health (...) (The Lancet 401, 10376 (2023))

26 January

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Six pills less: no benefit for bicarbonate supplementation in renal allograft recipients - Klemens Budde, Fabian Halleck Lancet
  Metabolic acidosis (defined as serum bicarbonate (The Lancet 401, 10376 (2023))
• 00:30
  [Comment] Nutrition in critical illness—research is worth the EFFORT - Emma J Ridley, Lee-anne S Chapple Lancet
  Multiple high-quality randomised controlled trials conducted over the past decade in critical care nutrition have shown no difference between interventions and routine care.1–4 These findings have led to the assumption that nutrition in critical illness is an innocuous, supportive therapy (...) (The Lancet 401, 10376 (2023))
• 00:30
  [Articles] Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial - Nilufar Mohebbi, Alexander Ritter, Anna Wiegand, Nicole Graf, Suzan Dahdal, Daniel Sidler, Spyridon Arampatzis, Karine Hadaya, Thomas F Mueller, Carsten A Wagner, Rudolf P Wüthrich Lancet
  In adult kidney transplant recipients, correction of metabolic acidosis by treatment with sodium bicarbonate over 2 years did not affect the decline in estimated GFR. Thus, treatment with sodium bicarbonate should not be generally recommended to preserve estimated GFR (a surrogate marker for (...) (The Lancet 401, 10376 (2023))
• 00:30
  [Articles] The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial - Daren K Heyland, Jayshil Patel, Charlene Compher, Todd W Rice, Danielle E Bear, Zheng-Yii Lee, Victoria C González, Kevin O'Reilly, Racquel Regala, Courtney Wedemire, Miguel Ibarra-Estrada, Christian Stoppe, Luis Ortiz-Reyes, Xuran Jiang, Andrew G Day, EFFORT Protein Trial team Lancet
  Delivery of higher doses of protein to mechanically ventilated critically ill patients did not improve the time-to-discharge-alive from hospital and might have worsened outcomes for patients with acute kidney injury and high organ failure (...) (The Lancet 401, 10376 (2023))
• 00:30
  [Department of Error] Department of Error Lancet
  The Lancet. The COVID-19 pandemic in 2023: far from over. Lancet 2023; 401: 79—The US Centers for Disease Control and Prevention revised their estimates of how many cases of COVID-19 were caused by XBB.1.5 at the end of December, down to 20·1%, not 40·5%. The revised figures no longer indicate a (...) (The Lancet 401, 10374 (2023))

25 January

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Getting ahead of insecticide-resistant malaria vector mosquitoes - Gerry F Killeen, Seynabou Sougoufara Lancet
  In The Lancet, Manfred Accrombessi and colleagues1 report the results of a rigorous cluster-randomised, controlled, superiority trial in Benin, encompassing 54 030 households and 216 289 people, which confirms that the addition of the pyrrole insecticide chlorfenapyr to long-lasting (...) (The Lancet 401, 10375 (2023))
• 00:30
  [Articles] Efficacy of pyriproxyfen-pyrethroid long-lasting insecticidal nets (LLINs) and chlorfenapyr-pyrethroid LLINs compared with pyrethroid-only LLINs for malaria control in Benin: a cluster-randomised, superiority trial - Manfred Accrombessi, Jackie Cook, Edouard Dangbenon, Boulais Yovogan, Hilaire Akpovi, Arthur Sovi, Constantin Adoha, Landry Assongba, Aboubacar Sidick, Bruno Akinro, Razaki Ossè, Filémon Tokponnon, Rock Aïkpon, Aurore Ogouyemi-Hounto, Germain Gil Padonou, Immo Kleinschmidt, Louisa A Messenger, Mark Rowland, Corine Ngufor, Natacha Protopopoff, Martin C Akogbeto Lancet
  Over 2 years, chlorfenapyr-pyrethroid LLINs provided greater protection from malaria than pyrethroid-only LLINs in an area with pyrethroid-resistant mosquitoes. Pyriproxyfen-pyrethroid LLINs conferred protection similar to pyrethroid-only LLINs. These findings provide crucial second-trial (...) (The Lancet 401, 10375 (2023))

24 January

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Perspectives] Picturing health: migrants' stories in Ciudad Juárez, Mexico - Danielle Villasana Lancet
  Although Ciudad Juárez, a city situated on the USA–Mexico border, has been affected by femicide, drug-trafficking, and other challenges, migrants from Latin America and elsewhere continue to arrive here hoping to seek asylum in the USA. As a photojournalist focusing on issues related to gender, (...) (The Lancet 401, 10376 (2023))
• 00:30
  [Articles] Performance of cardiovascular disease risk prediction equations in more than 14 000 survivors of cancer in New Zealand primary care: a validation study - Essa Tawfiq, Vanessa Selak, J Mark Elwood, Romana Pylypchuk, Sandar Tin Tin, Matire Harwood, Corina Grey, Mark McKeage, Sue Wells Lancet
  The New Zealand cardiovascular disease risk prediction equations reasonably predicted the observed 5-year cardiovascular disease risk in survivors of cancer in the country, in whom risk prediction was considered clinically appropriate. Prediction could be improved by adding cancer-specific (...) (The Lancet 401, 10374 (2023))
• 00:30
  [Comment] Cardiovascular risk assessment in survivors of cancer - Xavier Rossello Lancet
  Risk assessment has become pivotal in the prevention of cardiovascular disease. Risk prediction tools are intended to estimate prognosis in an unbiased and reliable way, and to provide objective outcome probabilities.1 Although the use of such tools is recommended by European2 and American3 (...) (The Lancet 401, 10374 (2023))

21 January

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Human security and universal health coverage: Japan's vision for the G7 Hiroshima Summit - Fumio Kishida Lancet
  The COVID-19 pandemic has made an unprecedented impact on the international community and exposed the vulnerabilities of the present global health architecture. Better governance and finance measures are urgently needed to strengthen pandemic prevention, preparedness, and response (PPR) for (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Comment] Adjuvant therapy in biliary tract cancers: oral fluoropyrimidine as a beginning - Nai-Jung Chiang, Li-Tzong Chen Lancet
  Biliary tract cancer is a group of malignant tumours, mostly adenocarcinoma, arising from different sites of the biliary tract with diverse aetiology, molecular profiling, TNM classification, and surgical procedures and outcomes of resectable diseases.1 Radical surgical resection remains the (...) (The Lancet 401, 10372 (2023))
• 00:00
  [Comment] Winner of the 2022 Wakley–Wu Lien Teh Prize: the dutiful son by his father's bedside - Helena Hui Wang, Esther Lau, Baoguo Jiang, Richard Horton Lancet
  The 2022 Wakley–Wu Lien Teh Prize invited submissions sharing ideas of “a heart full of great compassion and empathy” in modern Chinese clinical practice.1 We are pleased and grateful to have received 187 submissions—twice the number of submissions in 2021—telling touching and provocative stories (...) (The Lancet 401, 10372 (2023))
• 00:00
  [Comment] Offline: Rethinking the world - Richard Horton Lancet
  “The horror is that for the first time we live in a world in which we can no longer imagine a better one.” Theodor Adorno, in conversation with Max Horkheimer, in March, 1956. Adorno succeeded Horkheimer as Director of the Institute for Social Research at the University of Frankfurt in 1959. (...) (The Lancet 401, 10372 (2023))
• 00:00
  [World Report] One Health in Kenya - Laura Salm-Reifferscheidt Lancet
  Policy makers and researchers have long argued for the importance of One Health. Kenya is putting the principles into practice. Laura Salm-Reifferscheidt reports. (The Lancet 401, 10372 (2023))
• 00:00
  [World Report] Birthing on Country: improving maternal care in Australia - Sophie Cousins Lancet
  First Nations mothers and babies in Australia have long suffered inequities. A set of new initiatives is aiming to reverse this trend. Sophie Cousins reports. (The Lancet 401, 10372 (2023))
• 00:00
  [Perspectives] Carlos E Rodríguez-Díaz: community centred public health scientist - Udani Samarasekera Lancet
  “I am a community centred scientist, meaning I don’t do any public health work that is not relevant to the community”, says Carlos E Rodríguez-Díaz, Associate Professor and Vice Chair of the Department of Prevention and Community Health at George Washington University–Milken Institute School of (...) (The Lancet 401, 10372 (2023))
• 00:00
  [Perspectives] Digitising tremor - Scott L Delp, Eric J Topol Lancet
  The nervous system speaks a digital language. A heathy nervous system orchestrates a vast array of action potentials to produce a repertoire of voluntary movements. Neurological diseases such as parkinson's disease and essential tremor (ET), however, disrupt the execution of smooth voluntary (...) (The Lancet 401, 10372 (2023))
• 00:00
  [Perspectives] Can I listen to your heart now? - Réiltín Tynan Lancet
  The first person to call me doctor changed the course of my career. My fleeting encounter with Mary will be one of many transient ties that ultimately sustain a lifetime in health care. Like many patients, hers was an uneventful hospital stay. She had recovered well postoperatively, and treated (...) (The Lancet 401, 10372 (2023))
• 00:00
  [Correspondence] Latent bipolar depression - Takeshi Terao Lancet
  I read with much interest the excellent and comprehensive Seminar about depression in young people by Anita Thapar and colleagues.1 Although the authors simply mentioned the increased rates of diagnostic conversion from depression to bipolar disorder in adolescents with depression, it should be (...) (The Lancet 401, 10372 (2023))
• 00:00
  [Correspondence] Latent bipolar depression – Authors' reply - Olga Eyre, Vikram Patel, David Brent, Anita Thapar Lancet
  We thank Takeshi Terao for their response to our Seminar on depression in young people.1 Terao highlights that depression is often the first manifestation of bipolar disorder and early-onset depression is a risk factor for switching to bipolar disorder. This clinical point is (...) (The Lancet 401, 10372 (2023))
• 00:00
  [Correspondence] Who really benefits from drug combinations and long titrations for pain? - Thomas L Perry Lancet
  Findings from Solomon Tesfaye and colleagues’ OPTION-DM trial1 are a useful but intellectually challenging contribution to understanding drug treatment of painful neuropathy. It reiterates a popular expert opinion that gabapentin must be given three times daily and “requires a long titration (...) (The Lancet 401, 10372 (2023))
• 00:00
  [Correspondence] Who really benefits from drug combinations and long titrations for pain? – Authors' reply - Solomon Tesfaye, Gordon Sloan, David White, Mike Bradburn, Didier Bouhassira, Dinesh Selvarajah, OPTION-DM trial group Lancet
  We thank Thomas Perry for taking the time to read and respond to our work. In the OPTION-DM trial,1 we included pregabalin rather than gabapentin as pregabalin is a twice-daily drug that made blinded dosing easier for the trial, has 3–4 times faster absorption after oral administration, has (...) (The Lancet 401, 10372 (2023))
• 00:00
  [Correspondence] Convexity subarachnoid haemorrhage - David J Werring, Gargi Banerjee Lancet
  We congratulate Jan Claassen and Soojin Park on their Seminar on spontaneous subarachnoid haemorrhage (SAH);1 however, we found no mention of non-aneurysmal convexity subarachnoid haemorrhage (cSAH), a SAH subtype associated with a short, but important, list of underlying diagnoses, which (...) (The Lancet 401, 10372 (2023))
• 00:00
  [Correspondence] Convexity subarachnoid haemorrhage – Authors' reply - Jan Claassen, Soojin Park Lancet
  We thank David Werring and Gargi Banerjee for their kind comments on our Seminar,1 and for highlighting the important topic of convexity subarachnoid haemorrhage (cSAH). Due to space limitations, the nuances of the diagnostic approach and thorough reporting of clinical characteristics of the (...) (The Lancet 401, 10372 (2023))
• 00:00
  [Articles] Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial - Kohei Nakachi, Masafumi Ikeda, Masaru Konishi, Shogo Nomura, Hiroshi Katayama, Tomoko Kataoka, Akiko Todaka, Hiroaki Yanagimoto, Soichiro Morinaga, Shogo Kobayashi, Kazuaki Shimada, Yu Takahashi, Toshio Nakagohri, Kunihito Gotoh, Ken Kamata, Yasuhiro Shimizu, Makoto Ueno, Hiroshi Ishii, Takuji Okusaka, Junji Furuse, Hepatobiliary and Pancreatic Oncology Group of the Japan Clinical Oncology Group (JCOG-HBPOG) Lancet
  Although long-term clinical benefit would be needed for a definitive conclusion, a significant improvement in survival suggested adjuvant S-1 could be considered a standard of care for resected biliary tract cancer in Asian patients. (The Lancet 401, 10372 (2023))
• 00:00
  [Clinical Picture] Tumefactive multiple sclerosis presents with painless progressive hemiparesis and aphasia - Michael Guger, Gerhard Ransmayr, Michael Sonnberger, Simon Hametner, Serge Weis, Thomas Berger, Christian Enzinger Lancet
  A 20-year-old man presented at our emergency department with a progressive painless paralysis of his right arm and right leg. The patient reported that difficulties began approximately 48 h before, while he was sleeping. He had no medical (...) (The Lancet 401, 10372 (2023))
• 00:00
  [Wakley-Wu Lien Teh Prize Essay] ???? - ?? ? Lancet
  “????????” (The Lancet 401, 10372 (2023))
• 00:00
  [Editorial] One Health: a call for ecological equity - The Lancet Lancet
  The notion that the wellbeing of an individual is directly connected to the wellbeing of the land has a long history in Indigenous societies. Nowadays, the term One Health has become an important concept in global health. The One Health High-Level Expert panel defines One Health as “an (...) (The Lancet 401, 10372 (2023))

20 January

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Seminar] Asthma - Celeste Porsbjerg, Erik Melén, Lauri Lehtimäki, Dominick Shaw Lancet
  Asthma is one of the most common chronic non-communicable diseases worldwide and is characterised by variable airflow obstruction, causing dyspnoea and wheezing. Highly effective therapies are available; asthma morbidity and mortality have vastly improved in the past 15 years, and most patients (...) (The Lancet 401, 10379 (2023))
• 00:30
  [Series] How prepared is the world? Identifying weaknesses in existing assessment frameworks for global health security through a One Health approach - Tieble Traore, Sarah Shanks, Najmul Haider, Kanza Ahmed, Vageesh Jain, Simon R Rüegg, Ahmed Razavi, Richard Kock, Ngozi Erondu, Afifah Rahman-Shepherd, Alexei Yavlinsky, Leonard Mboera, Danny Asogun, Timothy D McHugh, Linzy Elton, Oyeronke Oyebanji, Oyeladun Okunromade, Rashid Ansumana, Mamoudou Harouna Djingarey, Yahaya Ali Ahmed, Amadou Bailo Diallo, Thierno Balde, Ambrose Talisuna, Francine Ntoumi, Alimuddin Zumla, David Heymann, Ibrahima Socé Fall, Osman (...) Lancet
  The COVID-19 pandemic has exposed faults in the way we assess preparedness and response capacities for public health emergencies. Existing frameworks are limited in scope, and do not sufficiently consider complex social, economic, political, regulatory, and ecological factors. One Health, (...) (The Lancet 401, 10377 (2023))
• 00:30
  [Series] Global and regional governance of One Health and implications for global health security - Azza Elnaiem, Olaa Mohamed-Ahmed, Alimuddin Zumla, Jeffrey Mecaskey, Nora Charron, Mahamat Fayiz Abakar, Tajudeen Raji, Ammad Bahalim, Logan Manikam, Omar Risk, Ebere Okereke, Neil Squires, John Nkengasong, Simon R Rüegg, Muzamil M Abdel Hamid, Abdinasir Y Osman, Nathan Kapata, Robyn Alders, David L Heymann, Richard Kock, Osman Dar Lancet
  The apparent failure of global health security to prevent or prepare for the COVID-19 pandemic has highlighted the need for closer cooperation between human, animal (domestic and wildlife), and environmental health sectors. However, the many institutions, processes, regulatory frameworks, and (...) (The Lancet 401, 10377 (2023))
• 00:30
  [Series] A global analysis of One Health Networks and the proliferation of One Health collaborations - Athman Mwatondo, Afifah Rahman-Shepherd, Lara Hollmann, Scott Chiossi, Josphat Maina, Karishma Krishna Kurup, Osama Ahmed Hassan, Beatrice Coates, Mishal Khan, Julia Spencer, Nyamai Mutono, Samuel M Thumbi, Mathew Muturi, Mumbua Mutunga, Liã Bárbara Arruda, Melika Akhbari, Dena Ettehad, Francine Ntoumi, Terence P Scott, Louis H Nel, Johanne Ellis-Iversen, Ute Wolff Sönksen, Diana Onyango, Zuleka Ismail, Kebadu Simachew, David Wolking, Rudovick Kazwala, Zikankuba Sijali, Bernard Bett, David Heymann, Richard Kock, Alimuddin Zumla, Osman (...) Lancet
  There has been a renewed focus on threats to the human–animal–environment interface as a result of the COVID-19 pandemic, and investments in One Health collaborations are expected to increase. Efforts to monitor the development of One Health Networks (OHNs) are essential to avoid duplication or (...) (The Lancet 401, 10376 (2023))
• 00:30
  [Comment] One Health action for health security and equity - One Health High-Level Expert Panel Lancet
  The importance of integrated One Health approaches to reduce the likelihood and impacts of emerging infectious disease outbreaks has been widely accepted, as the Lancet series on One Health emphasises.1–4 However, implementing One Health requires transdisciplinary approaches, with a systemic (...) (The Lancet 401, 10376 (2023))
• 00:30
  [Series] Advancing One human–animal–environment Health for global health security: what does the evidence say? - Jakob Zinsstag, Andrea Kaiser-Grolimund, Kathrin Heitz-Tokpa, Rajesh Sreedharan, Juan Lubroth, François Caya, Matthew Stone, Hannah Brown, Bassirou Bonfoh, Emily Dobell, Dilys Morgan, Nusrat Homaira, Richard Kock, Jan Hattendorf, Lisa Crump, Stephanie Mauti, Victor del Rio Vilas, Sohel Saikat, Alimuddin Zumla, David Heymann, Osman Dar, Stéphane de la Rocque Lancet
  In this Series paper, we review the contributions of One Health approaches (ie, at the human–animal–environment interface) to improve global health security across a range of health hazards and we summarise contemporary evidence of incremental benefits of a One Health approach. We assessed how (...) (The Lancet 401, 10376 (2023))

18 January

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] COVID-19 vaccination is effective at preventing severe illness and complications during pregnancy - Sascha Ellington, Tara C Jatlaoui Lancet
  Pregnancy increases the risk of severe illness and death from COVID-19; moreover, SARS-CoV-2 infection during pregnancy is associated with increased risk for adverse pregnancy and neonatal outcomes, such as preterm birth, stillbirth, and neonatal death.1 COVID-19 vaccination is the most (...) (The Lancet 401, 10375 (2023))
• 00:30
  [Articles] Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study - Jose Villar, Constanza P Soto Conti, Robert B Gunier, Shabina Ariff, Rachel Craik, Paolo I Cavoretto, Stephen Rauch, Serena Gandino, Ricardo Nieto, Adele Winsey, Camilla Menis, Gabriel B Rodriguez, Valeria Savasi, Niyazi Tug, Sonia Deantoni, Marta Fabre, Begoña Martinez de Tejada, Maria Jose Rodriguez-Sibaja, Stefania Livio, Raffaele Napolitano, Nerea Maiz, Helena Sobrero, Ashley Peterson, Philippe Deruelle, Carolina Giudice, Jagjit S Teji, Roberto A Casale, Laurent J Salomon, Federico Prefumo, Leila Cheikh Ismail, Michael G Gravett, Marynéa Vale, Valeria Hernández, Loïc Sentilhes, Sarah R (...) Lancet
  COVID-19 in pregnancy, during the first 6 months of omicron as the variant of concern, was associated with increased risk of severe maternal morbidity and mortality, especially among symptomatic and unvaccinated women. Women with complete or boosted vaccine doses had reduced risk for severe (...) (The Lancet 401, 10375 (2023))
• 00:30
  [Comment] Postoperative antibiotics can be de-escalated after laparoscopic surgery for complex appendicitis - Aneel Bhangu, Pamela Buchwald, Faustin Ntirenganya Lancet
  Appendicitis is the most common surgical emergency globally, and surgery remains the mainstay of treatment in more than 98% of cases.1,2 However, variations in management are extremely common and are under-researched. For example, there is little agreement over the best preoperative diagnostic (...) (The Lancet 401, 10374 (2023))
• 00:30
  [Articles] 2 days versus 5 days of postoperative antibiotics for complex appendicitis: a pragmatic, open-label, multicentre, non-inferiority randomised trial - Elisabeth M L de Wijkerslooth, Evert-Jan G Boerma, Charles C van Rossem, Joost van Rosmalen, Coen I M Baeten, Frédérique H Beverdam, Johanna W A M Bosmans, Esther C J Consten, Jan Willem T Dekker, Marloes Emous, Anna A W van Geloven, Anton F Gijsen, Luc A Heijnen, An P Jairam, Damian C Melles, Augustinus P T van der Ploeg, Pascal Steenvoorde, Boudewijn R Toorenvliet, Maarten Vermaas, Bas Wiering, Bas P L Wijnhoven, Anne Loes van den Boom, APPIC Study (...) Lancet
  2 days of postoperative intravenous antibiotics for complex appendicitis is non-inferior to 5 days in terms of infectious complications and mortality within 90 days, based on a non-inferiority margin of 7·5%. These findings apply to laparoscopic appendicectomy conducted in a well resourced (...) (The Lancet 401, 10374 (2023))

17 January

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Clinical Picture] A case of parotitis caused by hMPX virus - Marieke de Regt, Rogier Ooijevaar, Marcel Jonges, Matthijs R A Welkers, Alex Wagemakers Lancet
  A 26-year-old man reporting a 6-day history of fever, malaise, and a swollen cheek, was referred to our emergency room. The day before his attendance, he had been seen by his general practitioner and started on oral amoxicillin and clavulanic acid. However, his cheek continued to swell, and he (...) (The Lancet 401, 10374 (2023))

14 January

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Correspondence] COVID-19 and other pandemics require a coherent response strategy - Michael G Baker, David Durrheim, Li Yang Hsu, Nick Wilson Lancet
  Future pandemic responses demand a globally coherent approach based on the costly lessons learnt during the COVID-19 pandemic. These themes are discussed in the comprehensive Lancet Commission by Sachs and colleagues,1 and in reports from throughout 2022 on the mpox (formerly known as (...) (The Lancet 401, 10373 (2023))
• 00:00
  [Editorial] The COVID-19 pandemic in 2023: far from over - The Lancet Lancet
  3 years ago, on Jan 5, 2020, the Department of Zoonoses at the National Institute of Communicable Disease Control and Prevention (Chinese Center for Disease Control and Prevention) announced the isolation of a new Coronavirus responsible for a wave of respiratory illnesses. On Jan 30, WHO (...) (The Lancet 401, 10371 (2023))
• 00:00
  [Comment] Offline: The mathematics of danger - Richard Horton Lancet
  Rishi Sunak, the UK's Prime Minister, last week announced his ambition that all school students would study some form of mathematics to the age of 18 years. He was sharply criticised by those who either hated maths at school or have prospered in life with little knowledge of mathematics. But (...) (The Lancet 401, 10371 (2023))
• 00:00
  [World Report] 10 years on—high-risk practices on the London gay scene - Tony Kirby, Michelle Thornber-Dunwell Lancet
  A decade after The Lancet investigated the explosion of high-risk drug practices on the London gay scene, Tony Kirby and Michelle Thornber-Dunwell return to analyse the landscape today. (The Lancet 401, 10371 (2023))
• 00:00
  [Perspectives] Kumanan Rasanathan: committed advocate of equity in health - Geoff Watts Lancet
  Kumanan Rasanathan, public health physician and Executive Director of the Geneva-based Alliance for Health Policy and Systems Research, quotes the 19th-century physician and polymath Rudolf Virchow, who famously suggested that “medicine is a social science, and politics nothing more than (...) (The Lancet 401, 10371 (2023))
• 00:00
  [Perspectives] Narrative medicine, narrative practice, and the creation of meaning - John Launer, Anita Wohlmann Lancet
  Medical interest in the study of narratives, whether those of patients or doctors, goes back a long way. However, the field of narrative medicine emerged in the late 20th century and is associated in many people's minds with two seminal texts. One was Narrative Based Medicine: Dialogue and (...) (The Lancet 401, 10371 (2023))
• 00:00
  [Correspondence] Medical education reforms in China - Jie Qiao, Yuanyuan Wang, Fei Kong, Yu Fu Lancet
  Julio Frenk and colleagues1 put forward education for life as a guiding principle for health-professional education after the COVID-19 pandemic. We concur with the need for a radical rethink of medical education systems worldwide, and would like to share responses and reflections from China at (...) (The Lancet 401, 10371 (2023))
• 00:00
  [Correspondence] Pseudovesicular appearance in Sweet's syndrome: important yet easily missed - Ya Bin Zhou Lancet
  Juan Bañares and colleagues1 reported a case of Sweet's syndrome, but an important diagnostic clue was neglected. Typical skin lesions of Sweet's syndrome are painful erythematous plaques or nodules.2 The lesions have a pseudovesicular appearance due to prominent papillary dermal oedema.2 The (...) (The Lancet 401, 10371 (2023))
• 00:00
  [Correspondence] Pseudovesicular appearance in Sweet's syndrome: important yet easily missed – Authors' reply - Juan Bañares, Laia Aceituno, Alba Jiménez, Avonello Maynard, Eduardo Dacosta Escobar, Carmen Alemán Lancet
  We are thankful to Ya Bin Zhou for the helpful comment about the appearance of skin lesions in the suspected diagnosis of Sweet's syndrome. Detailed physical examination is paramount to add up features that could narrow the differential diagnosis. In this case, and as Zhou shrewdly noticed, the (...) (The Lancet 401, 10371 (2023))
• 00:00
  [Department of Error] Department of Error Lancet
  Vaduganathan M, Docherty KF, Claggett BL, et al. SGLT2 inhibitors in patients with heart failure: a comprehensive meta-analysis of five randomised controlled trials. Lancet 2022; 400: 757–67—In this Article, the Research in context panel has been corrected to clarify that SOLOIST-WHF included (...) (The Lancet 401, 10371 (2023))
• 00:00
  [Department of Error] Department of Error Lancet
  Sheikh J, Allotey J, Kew T, et al. Effects of race and ethnicity on perinatal outcomes in high-income and upper-middle-income countries: an individual participant data meta-analysis of 2 198 655 pregnancies. Lancet 2022; 400: 2049–62—In this Article, the IPPIC Collaborative Network list and the (...) (The Lancet 401, 10371 (2023))
• 00:00
  [Clinical Picture] Spontaneous rupture of Achilles tendon xanthomas in a case of familial hypercholesterolaemia - Kota Murai, Masashi Fujino, Mariko Harada-Shiba, Satoshi Yasuda Lancet
  A 70-year-old man attended our hospital reporting a 2-week history of swelling and aching of his left ankle. He did not report any recent trauma or excessive physical activity. (The Lancet 401, 10371 (2023))

13 January

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Stopping epidemics when and where they occur - Els Torreele, Michel Kazatchkine, Joanne Liu, Mark Dybul, Mauricio Cárdenas, Sudhvir Singh, Helena Legido Quigley, Christine McNab, Ellen Johnson Sirleaf, Mariana Mazzucato, Helen Clark Lancet
  Throughout the COVID-19 pandemic, vaccines and other health tools have reached lower-income countries out-of-step with need and demand.1–3 Yet lessons from this pandemic to address such inequities are not catalysing the fundamental changes required.4 Similarly, despite the well known risk of (...) (The Lancet 401, 10374 (2023))

12 January

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Seminar] Acute aortic dissection - Thierry Carrel, Thoralf M Sundt, Yskert von Kodolitsch, Martin Czerny Lancet
  Although substantial progress has been made in the prevention, diagnosis, and treatment of acute aortic dissection, it remains a complex cardiovascular event, with a high immediate mortality and substantial morbidity in individuals surviving the acute period. The past decade has allowed a leap (...) (The Lancet 401, 10378 (2023))

7 January

Lancet https://www.thelancet.com/journals/lancet

• 00:00
  [Clinical Picture] Focusing on the eye signs of Alport syndrome in a 40-year-old man who previously had a kidney transplant and hearing loss - Bogdana Kovalchuk, Ramin Khoramnia Lancet
  A 40-year-old man attended our ophthalmology department reporting a gradual worsening of vision in both eyes over the previous few months. (The Lancet 401, 10370 (2023))
• 00:00
  [Editorial] The Lancet at 200: a start, but more to do - The Lancet Lancet
  Thomas Wakley, a 27-year-old apothecary, surgeon, and sometime boxer, founded The Lancet in 1823. Wakley's intention was to publish reports of metropolitan hospital lectures, at the time a highly profitable activity for a small coterie of powerful physicians and surgeons in London. In addition (...) (The Lancet 401, 10370 (2023))
• 00:00
  [Comment] Offline: Health's intercultural turn - Richard Horton Lancet
  We are trapped in a linguistic cage from which few of us can escape. We rarely complain. We are comfortable in our epistemological prisons, especially those of us who languish in Anglophone confinement. If we break free, we are afforded an insight into a different world, one where the (...) (The Lancet 401, 10370 (2023))
• 00:00
  [World Report] Increasing humanitarian concerns for 2023 - John Zarocostas Lancet
  Hard choices for humanitarians as UN seeks US$51·5 billion in emergency aid funds to address surging needs, John Zarocostas reports from Geneva. (The Lancet 401, 10370 (2023))
• 00:00
  [Perspectives] André Ilbawi: centring community-defined priorities in cancer care - Udani Samarasekera Lancet
  Speaking about WHO's latest cancer campaign to amplify the voices of people affected by cancer, André Ilbawi, Technical Lead for WHO's Cancer Control Programme, says it “focuses on better understanding and addressing the needs of people affected by cancer, so not only those that are diagnosed but (...) (The Lancet 401, 10370 (2023))
• 00:00
  [Perspectives] Advancing the commercial determinants of health agenda - Kelley Lee Lancet
  The landmark 1842 Report on the Sanitary Condition of the Labouring Population of Great Britain, by the social reformer Edwin Chadwick, was a damning indictment of how large-scale socioeconomic change during the 19th century contributed to the increased spread of epidemic and chronic diseases. (...) (The Lancet 401, 10370 (2023))
• 00:00
  [Perspectives] Unhealthy histories: sports and addictive sponsorship - Anna Greenwood, Alex Mold, Heather Wardle Lancet
  Professional sport has been criticised for its role as a vehicle to market addictive products or services. Despite the harmful health effects on society, football audiences are inured to seeing sponsors of such products not only on pitch-side hoardings and shirts, but also embedded in (...) (The Lancet 401, 10370 (2023))
• 00:00
  [Obituary] Eldryd Hugh Owen Parry - Geoff Watts Lancet
  Physician and founder of the Tropical Health and Education Trust. He was born in Cardiff, UK, on Nov 28, 1930 and died of pneumonia in London, UK, on Nov 13, 2022 aged 91 years. (The Lancet 401, 10370 (2023))
• 00:00
  [Correspondence] Cardiovascular risk in systemic autoimmune diseases - Satoshi Funada, Yan Luo, Norihiro Nishioka, Takashi Yoshioka Lancet
  In a large population-based observational study, Nathalie Conrad and colleagues1 showed the association between 19 autoimmune diseases and 12 cardiovascular diseases (CVDs) with data from about 22 000 000 people in the UK. However, we are concerned about the possibly confusing message caused by (...) (The Lancet 401, 10370 (2023))
• 00:00
  [Correspondence] Cardiovascular risk in systemic autoimmune diseases - Giacomo Cafaro, Carlo Perricone, Roberto Gerli, Elena Bartoloni Lancet
  In their impressive population-based study, Nathalie Conrad and colleagues1 found that people with systemic autoimmune disease have a significantly higher risk of developing cardiovascular disease (CVD) in comparison with the general population, to an extent similar to diabetes.1 Excess risk (...) (The Lancet 401, 10370 (2023))
• 00:00
  [Correspondence] Cardiovascular risk in systemic autoimmune diseases – Authors' reply - Nathalie Conrad, John J V McMurray Lancet
  We agree with Giacomo Cafaro and colleagues that comparing different types of cardiovascular outcomes occurring in people with systemic sclerosis to those occurring in patients with other autoimmune diseases would be of interest. However, our study1 included relatively few participants with (...) (The Lancet 401, 10370 (2023))
• 00:00
  [Correspondence] Application of a sex-specific GRACE score in practice - Dorien M Kimenai, Nicholas L Mills Lancet
  We wish to congratulate Florian A Wenzl and colleagues1 for their important analysis and update of the Global Registry of Acute Coronary Events (GRACE) score to address observed differences in the prediction of in-hospital mortality following non-ST-segment elevation acute coronary syndromes (...) (The Lancet 401, 10370 (2023))
• 00:00
  [Correspondence] Application of a sex-specific GRACE score in practice – Authors' reply - Florian A Wenzl, Thomas F Lüscher Lancet
  We thank Dorien M Kimenai and Nicholas L Mills for their interest in our Article.1 Indeed, sex-specific diagnostic thresholds of troponin were introduced into the Universal Definition of Myocardial Infarction in 2012 during the recruitment period of our study and have led to increased (...) (The Lancet 401, 10370 (2023))
• 00:00
  [Correspondence] Breast radiotherapy for non-low-risk ductal carcinoma in situ: to boost or not to boost? - Thomas Mulliez, Mark De Ridder Lancet
  Radiotherapy and tumour bed boost for ductal carcinoma in situ (DCIS) of the breast is the subject of many debates in tumour boards and radiotherapy departments. We thank Boon H Chua and colleagues1 for their well designed randomised trial comparing fractionation schedules and boost for (...) (The Lancet 401, 10370 (2023))
• 00:00
  [Correspondence] Breast radiotherapy for non-low-risk ductal carcinoma in situ: to boost or not to boost? – Authors' reply - Boon H Chua, Emma K Link, Ian H Kunkler, Ivo A Olivotto Lancet
  We welcome Thomas Mulliez and Mark De Ridder's comments on the BIG 3-07/TROG 07.01 study.1 The 15% increase in acute adverse events in patients who had a tumour bed boost compared with no boost after whole breast irradiation for ductal carcinoma in situ was mainly due to self-limiting radiation (...) (The Lancet 401, 10370 (2023))

23 December

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] PANORAMIC: important insights into molnupiravir use in COVID-19 - Michael R Kidd, Paul M Kelly Lancet
  Oral antivirals have been an important addition to efforts to minimise adverse COVID-19 outcomes in individuals at high risk. Although no head-to-head comparisons of the widely available treatments molnupiravir and nirmatrelvir–ritonavir have been published, early trial findings (done largely in (...) (The Lancet 401, 10373 (2023))
• 00:30
  [Articles] Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial - Christopher C Butler, F D Richard Hobbs, Oghenekome A Gbinigie, Najib M Rahman, Gail Hayward, Duncan B Richards, Jienchi Dorward, David M Lowe, Joseph F Standing, Judith Breuer, Saye Khoo, Stavros Petrou, Kerenza Hood, Jonathan S Nguyen-Van-Tam, Mahendra G Patel, Benjamin R Saville, Joe Marion, Emma Ogburn, Julie Allen, Heather Rutter, Nick Francis, Nicholas P B Thomas, Philip Evans, Melissa Dobson, Tracie-Ann Madden, Jane Holmes, Victoria Harris, May Ee Png, Mark Lown, Oliver van Hecke, Michelle A Detry, Christina T Saunders, Mark Fitzgerald, Nicholas S Berry, Lazaro Mwandigha, Ushma (...) Lancet
  Molnupiravir did not reduce the frequency of COVID-19-associated hospitalisations or death among high-risk vaccinated adults in the community. (The Lancet 401, 10373 (2023))
• 00:30
  [Comment] Climate change and the prescription pad - Cristina Richie, Aaron S Kesselheim, David S Jones Lancet
  Physicians are increasingly concerned about the climate crisis. In September, 2019, health-care professionals participating in Extinction Rebellion action blocked the entrance to the UK's Department for Business, Energy and Industrial Strategy to protest about impotent responses to climate (...) (The Lancet 401, 10372 (2023))
• 00:30
  [Obituary] George C Patton - Andrew Green Lancet
  Child and adolescent psychiatrist, psychiatric epidemiologist, and global leader in adolescent health. Born on Dec 31, 1954, in Melbourne, VIC, Australia, he died of gastric cancer on Dec 7, 2022, in Melbourne, aged 67 years. (The Lancet 401, 10371 (2023))
• 00:30
  [Correspondence] Uptake of monoclonal antibodies and antiviral therapies for COVID-19 in Scotland - Holly Tibble, Tanja Mueller, Euan Proud, Elliott Hall, Amanj Kurdi, Chris Robertson, Marion Bennie, Lana Woolford, Aziz Sheikh Lancet
  SARS-CoV-2 has kept evolving since it was first detected in 2019. Virus mutations have affected transmissibility, virulence, and the effectiveness of vaccines and COVID-19 therapeutics. In Scotland, treatments recently made available for use in patients with COVID-19 are sotrovimab, a (...) (The Lancet 401, 10371 (2023))

22 December

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Seminar] Cataracts - Maria Vittoria Cicinelli, John C Buchan, Maneck Nicholson, Varshini Varadaraj, Rohit C Khanna Lancet
  94 million people are blind or visually impaired globally, and cataract is the most common cause of blindness worldwide. However, most cases of blindness are avoidable. Cataract is associated with decreased quality of life and reduced life expectancy. Most cases of cataract occur after birth (...) (The Lancet 401, 10374 (2023))
• 00:30
  [Obituary] Nicole Schiegg - Andrew Green Lancet
  Global health communications specialist. Born on June 2, 1977, in Nashville, TN, USA, she died of colon cancer on Nov 5, 2022, in Washington, DC, USA, aged 45 years. (The Lancet 401, 10372 (2023))
• 00:30
  [Perspectives] Of sight, and insight - Richard Lane Lancet
  The story of the human eye, vision, human perception, and how we see the world continues to intrigue the realms of philosophy, psychology, and ophthalmology. But whether it was the 17th-century philosopher René Descartes and his theories of the brain's pineal gland representing the location of (...) (The Lancet 401, 10371 (2023))

21 December

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Review] Lung cancer screening - Scott J Adams, Emily Stone, David R Baldwin, Rozemarijn Vliegenthart, Pyng Lee, Florian J Fintelmann Lancet
  Randomised controlled trials, including the National Lung Screening Trial (NLST) and the NELSON trial, have shown reduced mortality with lung cancer screening with low-dose CT compared with chest radiography or no screening. Although research has provided clarity on key issues of lung cancer (...) (The Lancet 401, 10374 (2023))
• 00:30
  [Comment] Machine learning to assess coronary artery disease status—is it helpful? - Puneet Batra, Amit V Khera Lancet
  Over the past decade, massive, biologically rich datasets—and machine learning methods that can interrogate them—have allowed for the development of predictive cardiovascular disease diagnostics. These machine learning markers are designed to identify patients with undiagnosed disease or those at (...) (The Lancet 401, 10372 (2023))
• 00:30
  [Articles] Machine learning-based marker for coronary artery disease: derivation and validation in two longitudinal cohorts - Iain S Forrest, Ben O Petrazzini, Áine Duffy, Joshua K Park, Carla Marquez-Luna, Daniel M Jordan, Ghislain Rocheleau, Judy H Cho, Robert S Rosenson, Jagat Narula, Girish N Nadkarni, Ron Do Lancet
  Electronic health record-based machine learning was used to generate an in-silico marker for coronary artery disease that can non-invasively quantify atherosclerosis and risk of death on a continuous spectrum, and identify underdiagnosed (...) (The Lancet 401, 10372 (2023))

20 December

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Deaths from alcohol-related liver disease in the UK: an escalating tragedy - Michael E D Allison, Julia Verne, William Bernal, Michelle Clayton, Sam Cox, Ashwin Dhanda, John F Dillon, James Ferguson, Graham Foster, Ian Gilmore, Vanessa Hebditch, Rebecca Jones, Steven Masson, Beverley Oates, Paul Richardson, Julia Sinclair, Julia Wendon, David Wood Lancet
  In 2013, the UK National Confidential Enquiry into Patient Outcome and Death (NCEPOD) published Measuring the Units.1 This report on UK hospital deaths from alcohol-related liver disease in 2011 highlighted the avoidable nature of many of these deaths and found that care was less than good in (...) (The Lancet 401, 10375 (2023))
• 00:30
  [Department of Error] Department of Error Lancet
  Guttman-Yassky E, Simpson EL, Reich K, et al. An anti-OX40 antibody to treat moderate-to-severe atopic dermatitis: a multicentre, double-blind, placebo-controlled phase 2b study. Lancet 2022; published online Dec 9. https://doi.org/10.1016/S0140-6736(22)02037-2—In table 1 of this Article, the (...) (The Lancet 401, 10372 (2023))

17 December

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Review] Novel and emerging treatments for major depression - Steven Marwaha, Edward Palmer, Trisha Suppes, Emily Cons, Allan H Young, Rachel Upthegrove Lancet
  Depression is common, costly, debilitating, and associated with increased risk of suicide. It is one of the leading global public health problems. Although existing available pharmacological treatments can be effective, their onset of action can take up to 6 weeks, side-effects are common, and (...) (The Lancet 401, 10371 (2023))
• 00:00
  [Editorial] Pasteur's legacy in 21st century medicine - The Lancet Lancet
  The Lancet bids 2022 adieu with a commemoration of Louis Pasteur. Born in France on Dec 27, 1822, Pasteur was a young polymath when he embarked on a path of discovery with profound societal relevance. By the age of 40 years, he was a national hero and an international authority on microbiology, (...) (The Lancet 400, 10369 (2022))
• 00:00
  [Comment] A new cholinergic mechanism for antipsychotics: emraclidine and M4 muscarinic receptors - John Cookson, Ferdinand Jonsson Lancet
  Existing antipsychotic medicines have impressive effectiveness in treating acute episodes of schizophrenia and preventing relapses, providing enormous impact for many patients. However, they are associated with short-term and longer-term side-effects, and their effects are directed mainly at (...) (The Lancet 400, 10369 (2022))
• 00:00
  [Comment] Bacterial pathogens and climate change - Philimon N Gona, Alexander F More Lancet
  Although deaths caused by infections contribute substantially to global mortality and morbidity, analysis of mortality from bacterial infections has been sporadic, and often limited only to select pathogens. Generally, research has focused only on disease spread based on sample sizes that are (...) (The Lancet 400, 10369 (2022))
• 00:00
  [Comment] Science knows no country: fulfilling Louis Pasteur's legacy - Rebecca F Grais, Amadou A Sall, Stewart T Cole Lancet
  2022 marks the bicentenary of Louis Pasteur's birth. Pasteur's discoveries helped lay the foundation of modern public health, microbiology, and medicine. His legacy echoes in the many streets, schools, and hospitals that bear his name, and in the widespread use of pasteurised food worldwide. (...) (The Lancet 400, 10369 (2022))
• 00:00
  [Comment] Building on Pasteur's legacy: producing vaccines in Africa - Salim S Abdool Karim, Izukanji Sikazwe Lancet
  Louis Pasteur's legacy of translating scientific knowledge on vaccines to create a healthier world resonates with his comment that “Science knows no country because knowledge belongs to humanity, and is the torch which illuminates the world. Science is the highest personification of the nation (...) (The Lancet 400, 10369 (2022))
• 00:00
  [Comment] Louis Pasteur, COVID-19, and the social challenges of epidemics - Tamara Giles-Vernick, Phaik Yeong Cheah, Gustavo Matta, Nisia Trindade Lima Lancet
  December, 2022, will see two notable anniversaries: the 200th anniversary of the birth of Louis Pasteur and the third anniversary of China's announcement of the outbreak that would lead to the COVID-19 pandemic. These coinciding events provide an opportunity to reflect on past and current (...) (The Lancet 400, 10369 (2022))
• 00:00
  [Comment] Winner of the 2022 Wakley Prize: compassion and connection - Jessamy Bagenal, Benjamin Burlton, Bethany Gomersall, Joanna Palmer, Paula Preyzner, Maneet Virdi Lancet
  It was a privilege to read the many thought-provoking entries to this year's Wakley Prize, The Lancet's annual essay competition. Earlier this year, we invited submissions about compassion and connection in medicine.1 We were moved and engaged by the submitted essays and thank everyone who (...) (The Lancet 400, 10369 (2022))
• 00:00
  [World Report] Modest health goals for new US Congress - Susan Jaffe Lancet
  With Congress almost evenly split between Republicans and Democrats, consensus on any major health legislation is unlikely. Susan Jaffe reports from Washington, DC. (The Lancet 400, 10369 (2022))
• 00:00
  [World Report] Research focus: Pasteur Institute of Dakar - Talha Burki Lancet
  From yellow fever to COVID-19, the Pasteur Institute of Dakar has been leading African health research and response. Talha Burki reports. (The Lancet 400, 10369 (2022))
• 00:00
  [Perspectives] Louis Pasteur's public engagement - Ilana Löwy, William Bynum Lancet
  Concern with public engagement by scientists and doctors is nothing new, but one of its consummate early practitioners was born 200 years ago. Louis Pasteur (1822–95) was not a natural communicator with ordinary people from the wider community. Shy and reserved, he was happiest when he was (...) (The Lancet 400, 10369 (2022))
• 00:00
  [Perspectives] Highlights 2022: sharpening the focus on powerful health stories - Joanna Palmer, Highlights 2022 winning contributors Lancet
  Photographs have the power to inform and engage the viewer. Earlier this year, The Lancet invited submissions for Highlights, our annual photography competition. We were looking for pictures on any health-related topic that arrested our attention, and we were impressed by the rich variety of (...) (The Lancet 400, 10369 (2022))
• 00:00
  [Correspondence] Elsevier must end its fossil fuel partnerships and subsidies – Publisher's reply - Esra Erkal Lancet
  As a scientific publisher and information analytics company, we take our responsibility seriously. We have been supporting sustainability research and working to reduce our environmental impact for more than 15 years. In 2021, we made a firm pledge to become net zero for all direct and indirect (...) (The Lancet 400, 10369 (2022))
• 00:00
  [Department of Error] Department of Error Lancet
  PREP-IT Investigators. Aqueous skin antisepsis before surgical fixation of open fractures (Aqueous-PREP): a multiple-period, cluster-randomised, crossover trial. Lancet 2022; 400: 1334–44—For this Article, the indexing list of collaborators was missing and has been added. This correction has been (...) (The Lancet 400, 10369 (2022))
• 00:00
  [Articles] Emraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia: a two-part, randomised, double-blind, placebo-controlled, phase 1b trial - John H Krystal, John M Kane, Christoph U Correll, David P Walling, Matthew Leoni, Sridhar Duvvuri, Shrinal Patel, Ih Chang, Philip Iredale, Lillian Frohlich, Stacey Versavel, Pamela Perry, Raymond Sanchez, John Renger Lancet
  These data support further investigation of emraclidine as a once-daily treatment for schizophrenia without need for titration and with a potentially favourable side-effect profile. (The Lancet 400, 10369 (2022))
• 00:00
  [Clinical Picture] Recurrent rectal bleeding in a teenager caused by a cavernous haemangioma of the sigmoid colon - Marta Martín González, Álvaro Pineda Torcuato, Maria Luisa Martin Jimenez, Isabel Alonso Sebastián, Jose Luis Martinez Porras, Gala Silvestre Egea, Concepción Gonzalez Hernando Lancet
  An 18-year-old woman was admitted to our hospital for investigation of repeated episodes of rectal bleeding. Over the preceding 5 months the patient had made 4 visits to our emergency room reporting bleeding from the rectum. The problem was not associated with any other symptoms and was (...) (The Lancet 400, 10369 (2022))
• 00:00
  [Review] Innovation for infection prevention and control—revisiting Pasteur's vision - Gabriel Birgand, Raheelah Ahmad, Andre N H Bulabula, Sanjeev Singh, Gonzalo Bearman, Enrique Castro Sánchez, Alison Holmes Lancet
  Louis Pasteur has long been heralded as one of the fathers of microbiology and immunology. Less known is Pasteur's vision on infection prevention and control (IPC) that drove current infection control, public health, and much of modern medicine and surgery. In this Review, we revisited (...) (The Lancet 400, 10369 (2022))
• 00:00
  [Viewpoint] A call to accelerate an end to human rabies deaths - S M Thumbi, Lucille Blumberg, Kevin le Roux, Naseem Salahuddin, Bernadette Abela Lancet
  Every year, an estimated 59 000 vaccine-preventable deaths occur globally due to rabies.1 These deaths occur despite more than 100 years of existence of effective vaccines against rabies in humans and dogs, which serve as the main source of infection for (...) (The Lancet 400, 10369 (2022))
• 00:00
  [Wakley Prize Essay] Directly observed therapy - Padmasayee Papineni Lancet
  “it was all about standing alone in a big grey city and somebody suddenly handing you marigolds” The Lift (2013), Janis Freegard (The Lancet 400, 10369 (2022))

16 December

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] The Lancet Commission on 21st-Century Global Health Threats - Natalia Kanem, Christopher J L Murray, Richard Horton Lancet
  The world has lived through an extraordinary global health threat, the COVID-19 pandemic, leading to nearly 20 million deaths, staggering economic losses, a generational decline in human capital, and the first decline in global life expectancy since 1950 (the first year when UN estimates were (...) (The Lancet 401, 10370 (2023))

15 December

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Community pandemic response: the importance of action led by communities and the public sector - Winnie Byanyima, Karl Lauterbach, Matthew M Kavanagh Lancet
  The world faces multiple intersecting pandemics: COVID-19 and mpox (formerly known as monkeypox) have joined HIV/AIDS and a current outbreak of Ebola virus disease to create a dangerous global disease environment. Climate change is making outbreaks more likely.1 An important question for global (...) (The Lancet 401, 10373 (2023))

10 December

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Long-term disease control in atopic dermatitis using biologics - Jacob P Thyssen, Peter Schmid-Grendelmeier Lancet
  Atopic dermatitis is an inflammatory, itchy skin condition characterised by a fluctuating and chronic disease course. Effective therapies inhibit downstream immune signalling of interleukin (IL)-4, IL-13, IL-31,1 and Janus kinase activity.2 Biologics that target upstream cytokines, such as (...) (The Lancet 401, 10372 (2023))
• 00:30
  [Articles] An anti-OX40 antibody to treat moderate-to-severe atopic dermatitis: a multicentre, double-blind, placebo-controlled phase 2b study - Emma Guttman-Yassky, Eric L Simpson, Kristian Reich, Kenji Kabashima, Ken Igawa, Tetsuya Suzuki, Hirotaka Mano, Takeshi Matsui, Ehsanollah Esfandiari, Masutaka Furue Lancet
  Patients treated with rocatinlimab had progressive improvements in atopic dermatitis, which was maintained in most patients after treatment discontinuation. Treatment was well tolerated. (The Lancet 401, 10372 (2023))

9 December

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Seminar] Congenital adrenal hyperplasia - Matthias K Auer, Anna Nordenström, Svetlana Lajic, Nicole Reisch Lancet
  Congenital adrenal hyperplasia is a group of autosomal recessive disorders leading to multiple complex hormonal imbalances caused by various enzyme deficiencies in the adrenal steroidogenic pathway. The most common type of congenital adrenal hyperplasia is due to steroid 21-hydroxylase (...) (The Lancet 401, 10372 (2023))

8 December

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] A second-generation antibody–drug conjugate to treat HER2-positive breast cancer - Elie Rassy, Suzette Delaloge Lancet
  Breast cancers overexpressing the human epidermal growth factor receptor 2 (HER2, also known as ERBB2) protein were historically associated with a poor prognosis.1 However, their dependence on HER2 led to the development of targeted monoclonal antibodies that transformed their natural history (...) (The Lancet 401, 10371 (2023))
• 00:30
  [Comment] Maximising the lessons learned from trial data after emergency use listing of a novel oral polio vaccine - Line M Nanque, Ane Bærent Fisker Lancet
  During the past 6 years, outbreaks of circulating vaccine-derived type 2 poliovirus (cVDPV2) originating from the live oral polio vaccine (OPV) have complicated the global efforts towards poliovirus eradication. Responding to cVDPV2 by providing doses of monovalent type 2 OPV (OPV2) carries the (...) (The Lancet 401, 10371 (2023))
• 00:30
  [Articles] Evaluation of the safety, immunogenicity, and faecal shedding of novel oral polio vaccine type 2 in healthy newborn infants in Bangladesh: a randomised, controlled, phase 2 clinical trial - Khaelqu Zaman, Ananda S Bandyopadhyay, Masuma Hoque, Christopher Gast, Mohammad Yunus, Khondoker M Jamil, Bernardo A Mainou, Jennifer L Konopka-Anstadt, William S Hendley, Annelet Vincent, Ralf Clemens, Sue Ann Costa Clemens, Allen G Ross, John D Clemens, Erman Tritama Lancet
  nOPV2 was well tolerated and immunogenic in newborn infants, with two doses, at birth and 4 weeks, resulting in almost 99% of infants having protective neutralising antibodies. (The Lancet 401, 10371 (2023))

7 December

Lancet https://www.thelancet.com/journals/lancet

• 14:30
  [Articles] Trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer: updated results from DESTINY-Breast03, a randomised, open-label, phase 3 trial - Sara A Hurvitz, Roberto Hegg, Wei-Pang Chung, Seock-Ah Im, William Jacot, Vinod Ganju, Joanne Wing Yan Chiu, Binghe Xu, Erika Hamilton, Srinivasan Madhusudan, Hiroji Iwata, Sevilay Altintas, Jan-Willem Henning, Giuseppe Curigliano, José Manuel Perez-Garcia, Sung-Bae Kim, Vanessa Petry, Chiun-Sheng Huang, Wei Li, Jean-Sebastien Frenel, Silvia Antolin, Winnie Yeo, Giampaolo Bianchini, Sherene Loi, Junji Tsurutani, Anton Egorov, Yali Liu, Jillian Cathcart, Shahid Ashfaque, Javier (...) Lancet
  Trastuzumab deruxtecan showed a significant improvement in overall survival versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer, as well as the longest reported median progression-free survival, reaffirming trastuzumab deruxtecan as the standard of care in the (...) (The Lancet 401, 10371 (2023))
• 01:01
  [Articles] Bimekizumab in patients with active psoriatic arthritis and previous inadequate response or intolerance to tumour necrosis factor-? inhibitors: a randomised, double-blind, placebo-controlled, phase 3 trial (BE COMPLETE) - Joseph F Merola, Robert Landewé, Iain B McInnes, Philip J Mease, Christopher T Ritchlin, Yoshiya Tanaka, Akihiko Asahina, Frank Behrens, Dafna D Gladman, Laure Gossec, Alice B Gottlieb, Diamant Thaçi, Richard B Warren, Barbara Ink, Deepak Assudani, Rajan Bajracharya, Vishvesh Shende, Jason Coarse, Laura C Coates Lancet
  Bimekizumab treatment led to superior improvements in joint and skin efficacy outcomes at week 16 compared with placebo in patients with psoriatic arthritis and inadequate response or intolerance to TNF? inhibitors. The safety profile of bimekizumab was consistent with previous phase 3 studies (...) (The Lancet 401, 10370 (2023))
• 01:01
  [Comment] Bimekizumab in psoriatic arthritis: a great leap forward? - Rubén Queiro Lancet
  Psoriatic arthritis is a chronic inflammatory arthritis that can affect up to a third of patients with psoriasis. Psoriatic arthritis can cause enthesosynovial inflammation and structural damage, which translates into a substantial decrease in functional capacity and an impact on quality of (...) (The Lancet 401, 10370 (2023))

6 December

Lancet https://www.thelancet.com/journals/lancet

• 01:30
  [Articles] Bimekizumab in patients with psoriatic arthritis, naive to biologic treatment: a randomised, double-blind, placebo-controlled, phase 3 trial (BE OPTIMAL) - Iain B McInnes, Akihiko Asahina, Laura C Coates, Robert Landewé, Joseph F Merola, Christopher T Ritchlin, Yoshiya Tanaka, Laure Gossec, Alice B Gottlieb, Richard B Warren, Barbara Ink, Deepak Assudani, Rajan Bajracharya, Vishvesh Shende, Jason Coarse, Philip J Mease Lancet
  Bimekizumab treatment had superior improvements in joint, skin, and radiographic efficacy outcomes at week 16 compared with placebo in patients with psoriatic arthritis who were naive to biologic DMARDs. The safety profile of bimekizumab, including the occurrence of fungal infections, was (...) (The Lancet 401, 10370 (2023))

3 December

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Correspondence] Elsevier must end its fossil fuel partnerships and subsidies - Alex Macmillan, Rhys Jones Lancet
  Elsevier, The Lancet's publisher, continues to subsidise climate pollution through analytic tools and new journals supporting coal, oil, and gas exploration and extraction—an ongoing partnership that is morally and materially (...) (The Lancet 400, 10369 (2022))

30 November

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [World Report] Oncology at CERN: accelerating radiotherapy - Jacqui Thornton Lancet
  Europe's centre for particle research is increasingly studying medical applications, such as radiotherapy for deep-seated tumours. Jacqui Thornton reports. (The Lancet 401, 10371 (2023))

26 November

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Seminar] Systemic sclerosis - Elizabeth R Volkmann, Kristofer Andréasson, Vanessa Smith Lancet
  Systemic sclerosis, also known as scleroderma, is a rare and complex autoimmune connective-tissue disease. Once considered an untreatable and unpredictable condition, research advancements have improved our understanding of its disease pathogenesis and clinical phenotypes and expanded our (...) (The Lancet 401, 10373 (2023))
• 00:30
  [Articles] Pregnancy outcomes after first-trimester treatment with artemisinin derivatives versus non-artemisinin antimalarials: a systematic review and individual patient data meta-analysis - Makoto Saito, Rose McGready, Halidou Tinto, Toussaint Rouamba, Dominic Mosha, Stephen Rulisa, Simon Kariuki, Meghna Desai, Christine Manyando, Eric M Njunju, Esperanca Sevene, Anifa Vala, Orvalho Augusto, Christine Clerk, Edwin Were, Sigilbert Mrema, William Kisinza, Josaphat Byamugisha, Mike Kagawa, Jan Singlovic, Mackensie Yore, Anna Maria van Eijk, Ushma Mehta, Andy Stergachis, Jenny Hill, Kasia Stepniewska, Melba Gomes, Philippe J Guérin, Francois Nosten, Feiko O ter Kuile, Stephanie (...) Lancet
  We found no evidence of embryotoxicity or teratogenicity based on the risk of miscarriage, stillbirth, or major congenital anomalies associated with ABT during the first trimester of pregnancy. Given that treatment with artemether–lumefantrine was associated with fewer adverse pregnancy outcomes (...) (The Lancet 401, 10371 (2023))
• 00:30
  [Comment] First-trimester use of ACTs for malaria treatment in pregnancy - Laurence Slutsker, Rose Gana Fomban Leke Lancet
  People who are pregnant are particularly susceptible to the consequences of malaria infection, including maternal anaemia, fetal loss, and low-birthweight neonates.1 Prevention of malaria in pregnancy is crucial, and pregnant people who develop malaria require effective case management.2 WHO (...) (The Lancet 401, 10371 (2023))
• 00:30
  [Articles] Rezafungin versus caspofungin for treatment of candidaemia and invasive candidiasis (ReSTORE): a multicentre, double-blind, double-dummy, randomised phase 3 trial - George R Thompson, Alex Soriano, Oliver A Cornely, Bart Jan Kullberg, Marin Kollef, Jose Vazquez, Patrick M Honore, Matteo Bassetti, John Pullman, Methee Chayakulkeeree, Ivan Poromanski, Cecilia Dignani, Anita F Das, Taylor Sandison, Peter G Pappas, ReSTORE trial investigators Lancet
  Our data show that rezafungin was non-inferior to caspofungin for the primary endpoints of day-14 global cure (EMA) and 30-day all-cause mortality (FDA). Efficacy in the initial days of treatment warrants evaluation. There were no concerning trends in treatment-emergent or serious adverse (...) (The Lancet 401, 10370 (2023))
• 00:30
  [Comment] Rezafungin and invasive candida infections: a new game changing antifungal? - Jesús Guinea Lancet
  Invasive candidiasis is a hospital-acquired infection with a high associated mortality.1 The antifungal drug armamentarium to manage patients with invasive candida infections is quite small and restricted to three drug families: the polyenes, the azoles, and the echinocandins. The Infectious (...) (The Lancet 401, 10370 (2023))

25 November

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Expression of concern: 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study - The Lancet Editors Lancet
  On Jan 8, 2021, The Lancet published an Article, 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study, by Chaolin Huang and colleagues.1 On Aug 28, 2021, The Lancet published an Article, 1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort (...) (The Lancet 401, 10371 (2023))

22 November

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Articles] Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019 - GBD 2019 Antimicrobial Resistance Collaborators Lancet
  The 33 bacterial pathogens that we investigated in this study are a substantial source of health loss globally, with considerable variation in their distribution across infectious syndromes and locations. Compared with GBD Level 3 underlying causes of death, deaths associated with these (...) (The Lancet 400, 10369 (2022))

19 November

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Global investments to optimise the health and wellbeing of children with disabilities: a call to action - Bolajoko O Olusanya, Adrian C Davis, Mijna Hadders-Algra, Scott M Wright Lancet
  On Nov 20, 2022, we celebrate World Children's Day and the theme this year is inclusion, for every child. However, children with disabilities have received little attention from global health and development stakeholders. (The Lancet 401, 10372 (2023))

18 November

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Antimicrobial resistance in cities: an overlooked challenge that requires a multidisciplinary approach - Clare I R Chandler, Susan Nayiga Lancet
  The theme of World Antibiotic Awareness Week on Nov 18–24, 2022 is “preventing antimicrobial resistance together”. This is an important message when global estimates of antimicrobial resistance (AMR) revealed a larger burden of disease in 2019 than expected, with deaths directly attributable to (...) (The Lancet 401, 10377 (2023))
• 00:30
  [Health Policy] Human rights and the COVID-19 pandemic: a retrospective and prospective analysis - Lawrence O Gostin, Eric A Friedman, Sara Hossain, Joia Mukherjee, Saman Zia-Zarifi, Chelsea Clinton, Umunyana Rugege, Paulo Buss, Miriam Were, Ames Dhai Lancet
  When the history of the COVID-19 pandemic is written, the failure of many states to live up to their human rights obligations should be a central narrative. The pandemic began with Wuhan officials in China suppressing information, silencing whistleblowers, and violating the freedom of (...) (The Lancet 401, 10371 (2023))
• 00:30
  [Seminar] Monkeypox - Oriol Mitjà, Dimie Ogoina, Boghuma K Titanji, Cristina Galvan, Jean-Jacques Muyembe, Michael Marks, Chloe M Orkin Lancet
  Monkeypox is a zoonotic illness caused by the monkeypox virus, an Orthopoxvirus in the same genus as the variola, vaccinia, and cowpox viruses. Since the detection of the first human case in the Democratic Republic of the Congo in 1970, the disease has caused sporadic infections and outbreaks, (...) (The Lancet 401, 10370 (2023))

16 November

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Climate change threatens our health and survival within decades - Anthony Costello, Marina Romanello, Stella Hartinger, Georgiana Gordon-Strachan, Saleemul Huq, Peng Gong, Tord Kjellstrom, Paul Ekins, Hugh Montgomery Lancet
  Climate change harms health in all populations.1 Heat-related illness and deaths are increasing worldwide, from heatstroke, adverse pregnancy outcomes, worsened kidney function, and adverse mental health effects.1,2 For those working outdoors, heat limits physical work and labour productivity, (...) (The Lancet 401, 10371 (2023))

11 November

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Correspondence] WHO Living Guidelines on antivirals for COVID-19 are evidence-based - Andrew Owen, Janet Victoria Diaz, Gordon Guyatt, François Lamontagne, Miriam Stegemann, Per Olav Vandvik, Thomas Agoritsas Lancet
  Mary Wu and colleagues1 suggest a change to WHO's COVID-19 treatment guidelines for monoclonal antibodies. These living guidelines were updated on Sept 16, 2022, with strong recommendations against the use of sotrovimab and casirivimab–imdevimab following the emergence of new SARS-CoV-2 variants (...) (The Lancet 400, 10369 (2022))

5 November

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Climate change, health, and discrimination: action towards racial justice - Thilagawathi Abi Deivanayagam, Sujitha Selvarajah, Jason Hickel, Renzo R Guinto, Priscila de Morais Sato, Jon Bonifacio, Sonora English, Mita Huq, Rita Issa, Hans Mulindwa, Heizal Patricia Nagginda, Chetna Sharma, Delan Devakumar Lancet
  The health impacts of climate change will affect everyone. But the consequences are unevenly distributed, falling much harder on some communities than others. Although discourse on climate change and health acknowledges principles of equity,1 little attention is given to underlying structural (...) (The Lancet 401, 10370 (2023))
• 21:39
  [Comment] Intravenous iron passes another endurance test in heart failure - Theresa A McDonagh, Daniel I Bromage, Antonio Cannata Lancet
  Iron deficiency is an important comorbidity in patients with heart failure, occurring in around 40% of patients with chronic heart failure and 70% of patients with acute heart failure.1,2 Iron deficiency is associated with a reduction in both quality of life and exercise capacity, and an (...) (The Lancet 400, 10369 (2022))
• 21:39
  [Articles] Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial - Paul R Kalra, John G F Cleland, Mark C Petrie, Elizabeth A Thomson, Philip A Kalra, Iain B Squire, Fozia Z Ahmed, Abdallah Al-Mohammad, Peter J Cowburn, Paul W X Foley, Fraser J Graham, Alan G Japp, Rebecca E Lane, Ninian N Lang, Andrew J Ludman, Iain C Macdougall, Pierpaolo Pellicori, Robin Ray, Michele Robertson, Alison Seed, Ian Ford, IRONMAN Study Group Lancet
  For a broad range of patients with heart failure, reduced left ventricular ejection fraction and iron deficiency, intravenous ferric derisomaltose administration was associated with a lower risk of hospital admissions for heart failure and cardiovascular death, further supporting the benefit of (...) (The Lancet 400, 10369 (2022))

3 November

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] The crisis of maternal and child health in Afghanistan - Leonard Rubenstein, Rabia Jalazai, Paul Spiegel, Nancy Glass Lancet
  In the past two decades, despite ongoing war, international development assistance and funding, channelled through Afghanistan's Ministry of Public Health, expanded access to primary care, improved government hospitals, and trained thousands of health-care providers in Afghanistan, especially (...) (The Lancet 401, 10371 (2023))

28 October

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] COVID-19 and other adult vaccines can drive global disease prevention - David B Agus, Aurélia Nguyen, Amadou Alpha Sall, John Bell Lancet
  The COVID-19 pandemic has led to a renewed recognition of the importance of disease prevention and public health globally. The progress in COVID-19 vaccine technology is a small portion of the pipeline of new vaccines and injectable therapies that could prevent leading causes of premature death (...) (The Lancet 401, 10370 (2023))

27 October

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Viewpoint] The legacy of the COVID-19 pandemic for childhood vaccination in the USA - Douglas J Opel, Noel T Brewer, Alison M Buttenheim, Timothy Callaghan, Richard M Carpiano, Chelsea Clinton, Jad A Elharake, Lisa C Flowers, Alison P Galvani, Peter J Hotez, Jason L Schwartz, Regina M Benjamin, Arthur Caplan, Renee DiResta, Rekha Lakshmanan, Yvonne A Maldonado, Michelle M Mello, Wendy E Parmet, Daniel A Salmon, Joshua M Sharfstein, Saad B Omer Lancet
  Before the onset of the COVID-19 pandemic, achievements in childhood vaccine coverage in the USA and globally appeared imperiled. Misinformation about vaccines was pervasive.1 Vaccine hesitancy––a motivational state of being conflicted about, or opposed to, vaccination––was a top ten global health (...) (The Lancet 401, 10370 (2023))

25 October

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Viewpoint] After 2 years of the COVID-19 pandemic, translating One Health into action is urgent - Thierry Lefrançois, Denis Malvy, Laetitia Atlani-Duault, Daniel Benamouzig, Pierre-Louis Druais, Yazdan Yazdanpanah, Jean-François Delfraissy, Bruno Lina Lancet
  The world is coping with the health, societal, and economic consequences of more than 2 years of the COVID-19 pandemic. Emerging diseases caused by new pathogens, or re-emerging infectious diseases, appear regularly and their frequency is increasing.1,2 Several research papers3–5 have shown that (...) (The Lancet 401, 10378 (2023))

7 October

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Correspondence] WHO's Therapeutics and COVID-19 Living Guideline on mAbs needs to be reassessed - Mary Y Wu, Edward J Carr, Ruth Harvey, Harriet V Mears, Svend Kjaer, Hermaleigh Townsley, Agnieszka Hobbs, Martina Ragno, Lou S Herman, Lorin Adams, Steve Gamblin, Michael Howell, Rupert Beale, Michael Brown, Bryan Williams, Sonia Gandhi, Charles Swanton, Emma C Wall, David L V Bauer Lancet
  An essential line of defence in a global living-with-COVID-19 policy is formed by effective therapeutic strategies for vulnerable patients,1 many of whom are excluded from treatment with nirmatrelvir–ritonavir (sold as Paxlovid, Pfizer) by virtue of their comorbidities or interacting (...) (The Lancet 400, 10369 (2022))

2 August

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Monkeypox as a PHEIC: implications for global health governance - Clare Wenham, Mark Eccleston-Turner Lancet
  Monkeypox was declared a Public Health Emergency of International Concern (PHEIC) by the WHO Director-General Tedros Adhanom Ghebreyesus on July 23, 2022. This is the seventh declaration of a PHEIC since 2005. The PHEIC is governed by the International Health Regulations (IHR). A PHEIC should (...) (The Lancet 400, 10369 (2022))

23 July

Lancet https://www.thelancet.com/journals/lancet

• 00:00
  [Editorial] Viral hepatitis elimination: a challenge, but within reach - The Lancet Lancet
  July 28 marks World Hepatitis Day. Hepatitis B and C are the two major forms of viral hepatitis, causing inflammation, damage to the liver, and sometimes cancer. Their burden is huge—more men acquired hepatitis B (890 000 cases) in 2019–20 than HIV (720 000 cases). In 2019, HIV caused 0·7 million (...) (The Lancet 400, 10348 (2022))
• 00:00
  [Comment] Atopic dermatitis: time for tailored therapy - Maurizio Mennini, Giovanni Di Nardo, Alessandro Giovanni Fiocchi Lancet
  Atopic dermatitis represents the most frequent chronic inflammatory skin disease, affecting up to 7% of adults and 25% of children.1 The pathogenesis includes inflammation, skin barrier dysfunction, dysbiosis, and modulation by environmental and genetic factors. Patients generally present with (...) (The Lancet 400, 10348 (2022))
• 00:00
  [Comment] Towards preventive treatment of rheumatoid arthritis - Jürgen Rech, Georg Schett Lancet
  Prevention of rheumatoid arthritis is an ambitious therapeutic goal. Once it has developed, rheumatoid arthritis is characterised by high chronicity and often requires lifelong treatment.1,2 Sustained drug-free remission is rare, especially in seropositive disease, which is defined by the (...) (The Lancet 400, 10348 (2022))
• 00:00
  [Comment] Contraceptive mix and informed choice - Manas Ranjan Pradhan Lancet
  Contraceptive use is associated with economic development, improved maternal and child health, education, and the empowerment of women and their family planning needs.1 These gains can also reduce poverty and slow population growth.2–3 Access to contraception supports the quest for gender (...) (The Lancet 400, 10348 (2022))
• 00:00
  [Comment] New HIV prevention approaches: promise, praxis, and pitfalls - Kenneth H Mayer, Nittaya Phanuphak, Nyaradzo Mgodi, Beatriz Grinsztejn Lancet
  More than a decade since the demonstration that antiretrovirals used for pre-exposure prophylaxis (PrEP) were safe and effective in decreasing HIV transmission, these medications remain underused, but continue to be needed, given the persistent burden of incident HIV infection, particularly in (...) (The Lancet 400, 10348 (2022))
• 00:00
  [Comment] The 2022 Wakley–Wu Lien Teh Prize Essay: compassion and connection in China - Helena Hui Wang, Esther Lau, Richard Horton Lancet
  More than 1300 years ago, the physician Sun Simiao, who is known as “China's King of Medicine”, described in On the Absolute Sincerity of Great Physicians (often called the Chinese Hippocratic Oath) that a great physician must develop a heart full of great compassion and empathy and vow to (...) (The Lancet 400, 10348 (2022))
• 00:00
  [World Report] UK explores whole-genome sequencing for newborn babies - Talha Burki Lancet
  A pilot programme will assess the risks and benefits of screening babies for a huge number of conditions. Talha Burki reports. (The Lancet 400, 10348 (2022))
• 00:00
  [World Report] Tackling heroin use in Mozambique - Sophie Cousins Lancet
  Heroin use has spiked in Mozambique, but harm-reduction programmes are being expanded in the hope of improving health. Sophie Cousins reports. (The Lancet 400, 10348 (2022))
• 00:00
  [Perspectives] Improving the engagement of scientists with the media - Philip Ball Lancet
  After publishing an account of a field of physics accused of hype when some high-profile claims were retracted, I was contacted by one of the field's critics. He had declined to be interviewed for my article, but nonetheless believed that it gave too prominent a voice to those with whom he (...) (The Lancet 400, 10348 (2022))
• 00:00
  [Perspectives] Photography and dignity in dementia care - Savannah Dodd Lancet
  As a photographer, I spend a lot of time telling other people's stories. But when my grandmother made the decision to move my grandad to a memory care facility, I felt it was time to turn the lens on my own family. I decided to explore aspects of my grandad's dementia, which ultimately led to a (...) (The Lancet 400, 10348 (2022))
• 00:00
  [Obituary] Colin Brian Blakemore - Geoff Watts Lancet
  Neurobiologist and public intellectual of science. He was born in Stratford-upon-Avon, UK, on June 1, 1944 and died of motor neuron disease in Oxford, UK, on June 27, 2022 aged 78 years. (The Lancet 400, 10348 (2022))
• 00:00
  [Correspondence] The importance of empathy - Iona Heath, Denis Pereira Gray Lancet
  Seamus O'Mahony1 makes some interesting points in his review of A Fortunate Man: the Story of a Country Doctor—a classic general practice book written by John Berger and Jean Mohrbut,2 but we believe he has gone seriously adrift in writing “be wary of empathy…In my view, empathy is often of little (...) (The Lancet 400, 10348 (2022))
• 00:00
  [Correspondence] The importance of empathy – Author's reply - Seamus O'Mahony Lancet
  Like many others, Iona Heath and Denis Pereira Gray seem to assume that the words empathy, sympathy, and compassion are interchangeable, but this is a mistake. Empathy means that one feels what another person is feeling; sympathy means that one understands what the person is feeling; compassion (...) (The Lancet 400, 10348 (2022))
• 00:00
  [Department of Error] Department of Error Lancet
  Wolf J, Hubbard S, Brauer M, et al. Effectiveness of interventions to improve drinking water, sanitation, and handwashing with soap on risk of diarrhoeal disease in children in low-income and middle-income settings: a systematic review and meta-analysis. Lancet 2022; 400: 48–59—In figure 2A of (...) (The Lancet 400, 10348 (2022))
• 00:00
  [Department of Error] Department of Error Lancet
  Perry D C, Achten J, Knight R, et al. Immobilisation of torus fractures of the wrist in children (FORCE): a randomised controlled equivalence trial in the UK. Lancet 2022; 400: 39–47—In this Article, the FORCE collaborator list has been updated. This correction has been made to the online version (...) (The Lancet 400, 10348 (2022))
• 00:00
  [Department of Error] Department of Error Lancet
  Burki T. New declaration on neglected tropical diseases endorsed. Lancet 2022; 400: 15—In this World Report, the donation pledged by Wellcome for research into treatments for snakebite envenoming should have been £80 million. This correction has been made to the online version as of July 21, (...) (The Lancet 400, 10348 (2022))
• 00:00
  [Articles] Efficacy and safety of abrocitinib versus dupilumab in adults with moderate-to-severe atopic dermatitis: a randomised, double-blind, multicentre phase 3 trial - Kristian Reich, Jacob P Thyssen, Andrew Blauvelt, Kilian Eyerich, Weily Soong, Zakiya P Rice, H Chih-ho Hong, Norito Katoh, Fernando Valenzuela, Marco DiBonaventura, Tamara A Bratt, Fan Zhang, Claire Clibborn, Ricardo Rojo, Hernan Valdez, Urs Kerkmann Lancet
  Abrocitinib 200 mg per day was more efficacious than dupilumab in adults with moderate-to-severe atopic dermatitis on background topical therapy in inducing early reductions of itch and atopic dermatitis disease signs. Both treatments were well tolerated over 26 (...) (The Lancet 400, 10348 (2022))
• 00:00
  [Articles] Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial - Doortje I Krijbolder, Marloes Verstappen, Bastiaan T van Dijk, Yousra J Dakkak, Leonie E Burgers, Aleid C Boer, Yune Jung Park, Marianne E de Witt-Luth, Karen Visser, Marc R Kok, Esmeralda T H Molenaar, Pascal H P de Jong, Stefan Böhringer, Tom W J Huizinga, Cornelia F Allaart, Ellis Niemantsverdriet, Annette H M van der Helm-van Mil Lancet
  Methotrexate, the cornerstone treatment of rheumatoid arthritis, initiated at the pre-arthritis stage of symptoms and subclinical inflammation, did not prevent the development of clinical arthritis, but modified the disease course as shown by sustained improvement in MRI-detected inflammation, (...) (The Lancet 400, 10348 (2022))
• 00:00
  [Articles] Measuring contraceptive method mix, prevalence, and demand satisfied by age and marital status in 204 countries and territories, 1970–2019: a systematic analysis for the Global Burden of Disease Study 2019 - Annie Haakenstad, Olivia Angelino, Caleb M S Irvine, Zulfiqar A Bhutta, Kelly Bienhoff, Corinne Bintz, Kate Causey, M Ashworth Dirac, Nancy Fullman, Emmanuela Gakidou, Thomas Glucksman, Simon I Hay, Nathaniel J Henry, Ira Martopullo, Ali H Mokdad, John Everett Mumford, Stephen S Lim, Christopher J L Murray, Rafael Lozano Lancet
  The dominance of one contraceptive method in some locations raises the question of whether family planning policies should aim to expand method mix or invest in making existing methods more accessible. Lower rates of demand satisfied among women aged 15–24 years are also concerning because (...) (The Lancet 400, 10348 (2022))
• 00:00
  [Clinical Picture] Inconsistency and incongruence: the two diagnostic pillars of functional movement disorder - Christopher W Hess, Alberto J Espay, Michael S Okun Lancet
  A 67-year-old woman, who had a 4-month history of a sudden onset of intermittent jerking movements with contortions of her head and right arm, attended our specialist unit. She had been seen earlier at another hospital where neuroimaging and electroencephalography were reported as normal. And (...) (The Lancet 400, 10348 (2022))

16 July

Lancet https://www.thelancet.com/journals/lancet

• 00:00
  [Editorial] Measuring the future of humanity for health - The Lancet Lancet
  Estimating the future is fraught with uncertainty. Time makes fools of all prophets. But the broad contours of humanity's destiny can be sketched, at least tentatively. The latest World Population Prospects 2022, published by the UN, provides provocative insights into what we might expect over (...) (The Lancet 400, 10347 (2022))
• 00:00
  [Comment] What is the right drug for insomnia disorder? - Myrto T Samara Lancet
  Cognitive behavioural therapy (CBT) is considered a first-line treatment for chronic insomnia disorder;1 nevertheless, few clinicians are trained to deliver this treatment, and exploring other options seems imperative. In The Lancet, Franco De Crescenzo and colleagues2 report a large and (...) (The Lancet 400, 10347 (2022))
• 00:00
  [Comment] Complex relationship between health and moderate alcohol use - Robyn Burton, Nick Sheron Lancet
  In The Lancet, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2020 Alcohol Collaborators1 provide a further study to systematically determine thresholds for low-risk alcohol consumption while considering background rates of disease. Overall, the authors estimated the (...) (The Lancet 400, 10347 (2022))
• 00:00
  [World Report] The UN reports global asymmetries in population growth - John Zarocostas Lancet
  A UN study highlights the rapid population growth in some countries versus the growing ageing populations and challenges ahead. John Zarocostas reports from Geneva. (The Lancet 400, 10347 (2022))
• 00:00
  [World Report] New HIV law welcomed in Argentina - Amy Booth Lancet
  The legislation also makes provisions for patients with viral hepatitis, tuberculosis, and sexually transmitted infections. Amy Booth reports from Buenos Aires. (The Lancet 400, 10347 (2022))
• 00:00
  [World Report] Climate change driving east Africa towards famine - Sharmila Devi Lancet
  Consecutive years of drought caused by climate change and La Niña have led to food insecurity in many parts of east Africa. Sharmila Devi reports. (The Lancet 400, 10347 (2022))
• 00:00
  [Perspectives] Mariana Mazzucato: leading a new type of economics - Jessamy Bagenal Lancet
  Mariana Mazzucato is a firebrand economist. In 2020, she became Chair of the WHO Council on the Economics of Health For All. “The idea was instead of doing the usual of saying invest in health because it's good for the economy, what if you said invest in health for all and backtrack to design an (...) (The Lancet 400, 10347 (2022))
• 00:00
  [Perspectives] The search for a sea of tranquility - Ann Jurecic Lancet
  Emily St John Mandel's best-selling novel, Station Eleven (2014), begins when an actor, playing King Lear onstage, collapses and dies. This premature death signals the arrival of a new virus that will spread with incomprehensible speed, killing most of the earth's population. Mandel's book is (...) (The Lancet 400, 10347 (2022))
• 00:00
  [Perspectives] Navigating recovery: the healing power of patients' narratives - Suzanne O'Sullivan Lancet
  The Miskito are Indigenous people of Nicaragua. They come from the Mosquito coast where remote villages nestle between the Caribbean Sea and lush jungle. Their communities are affected by a disorder called grisi siknis that manifests as highly contagious convulsions. It predominantly affects (...) (The Lancet 400, 10347 (2022))
• 00:00
  [Obituary] Michael Sela - Geoff Watts Lancet
  Chemical immunologist and President of the Weizmann Institute of Science. He was born in Tomaszów Mazowiecki, Poland, on March 2, 1924 and died in Rehovot, Israel, on May 27, 2022 aged 98 years. (The Lancet 400, 10347 (2022))
• 00:00
  [Correspondence] Ad-hoc medical mission for refugees in the Ukraine–Russia war: from vision to practice - Idit Tessler, Franco Oz Yehuda, Evgeni Gershman, Eyal Klang, Idit Matot, Tamara Kolitz Lancet
  On Feb 24, 2022, Russia invaded Ukraine, and the humanitarian crisis that resulted is ongoing. As of June 29, 2022, the UN Refugee Agency (UNRA) has recorded nearly 5·5 million refugees across Europe who have fled the combat zones in Ukraine. As men are not allowed to leave Ukraine, refugees are (...) (The Lancet 400, 10347 (2022))
• 00:00
  [Correspondence] The prohibition of nuclear weapons: a public health priority - Lucia Bisceglia, Pirous Fateh-Moghadam Lancet
  The ongoing conflict in Ukraine confirms how wars and armed conflicts are a serious threat to public health and environmental integrity. The crisis has made clear that nuclear war is closer than ever. (The Lancet 400, 10347 (2022))
• 00:00
  [Correspondence] Payment and progress in peer review - Hilary Humphreys Lancet
  Phaik Y Cheah and Jan Piasecki1 raise important issues about the peer review process arising from the assessment of Aczel and colleagues,2 including the under-representation of female reviewers and reviewers from low-income countries, and they suggest that payment for reviews should be trialled (...) (The Lancet 400, 10347 (2022))
• 00:00
  [Correspondence] Academic exploitation - Beverley Chalmers, Dana L Solomon Lancet
  We are delighted to see payment for peer reviewers proposed by Phaik Y Cheah and Jan Piasecki.1 This proposal reflects a broader problem in academia: exploitation of, and even mandating, free labour for career advancement. Publishing is only one example, extending beyond the peer review (...) (The Lancet 400, 10347 (2022))
• 00:00
  [Correspondence] A fair day's wage for a fair day's work - Daniel Guinart, Victor Pérez-Sola, Benedikt Lorenz Amann Lancet
  We read with interest the discussion about compensation for scientific peer review.1 Voluntary peer review used to be the foundation of high-quality science. Peer review was based on an honour system, by which scientists would review the work of their peers for free, as part of their scientific (...) (The Lancet 400, 10347 (2022))
• 00:00
  [Correspondence] No to paid peer review - Khaled Moustafa Lancet
  Peer review can last months or years in some cases. Paying peer reviewers can speed up the process and motivate reviewers to evaluate manuscripts more efficiently.1 However, using money to lure reviewers in a publishing system that is already fraught with inherent and structural biases will (...) (The Lancet 400, 10347 (2022))
• 00:00
  [Department of Error] Department of Error Lancet
  Kamdar M, Solomon SR, Arnason J, et al. Lisocabtagene maraleucel versus standard of care with salvage chemotherapy followed by autologous stem cell transplantation as second-line treatment in patients with relapsed or refractory large B-cell lymphoma (TRANSFORM): results from an interim (...) (The Lancet 400, 10347 (2022))
• 00:00
  [Articles] Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis - Franco De Crescenzo, Gian Loreto D'Alò, Edoardo G Ostinelli, Marco Ciabattini, Valeria Di Franco, Norio Watanabe, Ayse Kurtulmus, Anneka Tomlinson, Zuzana Mitrova, Francesca Foti, Cinzia Del Giovane, Digby J Quested, Phil J Cowen, Corrado Barbui, Laura Amato, Orestis Efthimiou, Andrea Cipriani Lancet
  Overall, eszopiclone and lemborexant had a favorable profile, but eszopiclone might cause substantial adverse events and safety data on lemborexant were inconclusive. Doxepin, seltorexant, and zaleplon were well tolerated, but data on efficacy and other important outcomes were scarce and do not (...) (The Lancet 400, 10347 (2022))
• 00:00
  [Articles] Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020 - GBD 2020 Alcohol Collaborators Lancet
  There is strong evidence to support recommendations on alcohol consumption varying by age and location. Stronger interventions, particularly those tailored towards younger individuals, are needed to reduce the substantial global health loss attributable to (...) (The Lancet 400, 10347 (2022))
• 00:00
  [Clinical Picture] Facial lymphoedema, viral warts, and myelodysplastic syndrome: the protean condition of GATA2 deficiency - Emily Claire Rudd, Austin Kulasekararaj, Tanya N Basu Lancet
  A 17-year-old man reporting a 3-year history of an acneiform eruption and a 4-month history of worsening swelling of his face, was referred to our specialist joint haematology-dermatology clinic. The patient had been found to have a monocytopenia of 0·2 × 109 per L (normal 0·2–1·0); he had no other (...) (The Lancet 400, 10347 (2022))

9 July

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Department of Error] Department of Error Lancet
  Abbara A, Rao B, Titanji BK, Boum Y, Zumla A. The monkeypox outbreak must amplify hidden voices in the global discourse. Lancet 2022; 400: 23—The title of this Correspondence has been corrected. This correction has been made to the online version as of July 8, (...) (The Lancet 400, 10347 (2022))
• 00:00
  [Comment] Intravenous thrombolysis before thrombectomy for acute ischaemic stroke - Pooja Khatri Lancet
  Before endovascular therapy, patients with ischaemic stroke due to occlusion of large arteries were treated with only intravenous thrombolysis, specifically alteplase. Intravenous thrombolysis recanalised about 25% of occluded large arteries, resulting in fewer than 30% of patients achieving (...) (The Lancet 400, 10346 (2022))
• 00:00
  [World Report] “Chaos” for patients and providers after US abortion ruling - Susan Jaffe Lancet
  A patchwork of state laws replace abortion rights once guaranteed by Roe v Wade. Susan Jaffe reports from Washington, DC. (The Lancet 400, 10346 (2022))
• 00:00
  [World Report] 6 million female health workers are unpaid or underpaid - Udani Samarasekera Lancet
  Experts say that the exploitation of women's labour has negative effects on health systems. Udani Samarasekera reports. (The Lancet 400, 10346 (2022))
• 00:00
  [World Report] Visa bureaucracy causing GPs to leave the UK - Jacqui Thornton Lancet
  The UK is desperate for General Practitioners but administrative burden is forcing some overseas trainees to consider changing career, move house, or leave the country. Jacqui Thornton reports. (The Lancet 400, 10346 (2022))
• 00:00
  [Perspectives] Leandro Mena: advancing sexual health in the USA - Udani Samarasekera Lancet
  “There are many challenges, it's a very complex problem”, says Leandro Mena about the prevention of sexually transmitted diseases (STD) in the USA. As the Director of the Division of STD Prevention in the National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention at the Centers for (...) (The Lancet 400, 10346 (2022))
• 00:00
  [Perspectives] Plant agency and planetary health - Helen Bynum Lancet
  Even before you enter the Rooted Beings gallery at the Wellcome Collection in London, UK, fascinating green things meet the eye. Ingela Ihrman's giant gauze renditions of a marine algae, gut weed (Ulva intestinalis), dangle through the spiral staircase as if the tide has gone out and they are (...) (The Lancet 400, 10346 (2022))
• 00:00
  [Obituary] Kwaku Ohene-Frempong - Andrew Green Lancet
  Paediatric haematologist-oncologist and authority on sickle cell disease. Born on March 13, 1946 in Kukurantumi, Ghana, he died of metastatic lung cancer on May 7, 2022 in Philadelphia, PA, USA, aged 76 years. (The Lancet 400, 10346 (2022))
• 00:00
  [Correspondence] Tachi Yamada: a missed global health leader - Jaime Sepulveda Lancet
  On June 5, 2022, Tachi Yamada was remembered by family and a legion of friends, colleagues, and students in a special gathering in Seattle, WA, USA. This date would have been his 77th birthday. Sadly, this global health titan passed away prematurely in August, (...) (The Lancet 400, 10346 (2022))
• 00:00
  [Articles] Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial - Urs Fischer, Johannes Kaesmacher, Daniel Strbian, Omer Eker, Christoph Cognard, Patricia S Plattner, Lukas Bütikofer, Pasquale Mordasini, Sandro Deppeler, Vitor M Pereira, Jean François Albucher, Jean Darcourt, Romain Bourcier, Guillon Benoit, Chrysanthi Papagiannaki, Ozlem Ozkul-Wermester, Gerli Sibolt, Marjaana Tiainen, Benjamin Gory, Sébastien Richard, Jan Liman, Marielle Sophie Ernst, Marion Boulanger, Charlotte Barbier, Laura Mechtouff, Liqun Zhang, Gaultier Marnat, Igor Sibon, Omid Nikoubashman, Arno Reich, Arturo Consoli, Bertrand Lapergue, Marc Ribo, Alejandro Tomasello, Suzana (...) Lancet
  Thrombectomy alone was not shown to be non-inferior to intravenous alteplase plus thrombectomy and resulted in decreased reperfusion rates. These results do not support omitting intravenous alteplase before thrombectomy in eligible (...) (The Lancet 400, 10346 (2022))
• 00:00
  [Articles] Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial - Peter J Mitchell, Bernard Yan, Leonid Churilov, Richard J Dowling, Steven J Bush, Andrew Bivard, Xiao Chuan Huo, Guoqing Wang, Shi Yong Zhang, Mai Duy Ton, Dennis J Cordato, Timothy J Kleinig, Henry Ma, Ronil V Chandra, Helen Brown, Bruce C V Campbell, Andrew K Cheung, Brendan Steinfort, Rebecca Scroop, Kendal Redmond, Ferdinand Miteff, Yan Liu, Dang Phuc Duc, Hal Rice, Mark W Parsons, Teddy Y Wu, Huy-Thang Nguyen, Geoffrey A Donnan, Zhong Rong Miao, Stephen M Davis, DIRECT-SAFE (...) Lancet
  We did not show non-inferiority of direct endovascular thrombectomy compared with bridging therapy. The additional information from our study should inform guidelines to recommend bridging therapy as standard treatment. (The Lancet 400, 10346 (2022))
• 00:00
  [Clinical Picture] Eosinophilic gastroenteritis with ascites: an enigmatic diagnosis - Pierre Galere, Allison Gilbert Lancet
  A 41-year-old woman presented to the emergency department with a 1-month history of worsening abdominal pain, nausea, and vomiting. The patient gave no history of recent travel, previous abdominal surgery, or adverse reactions to any allergens. She had no past medical problems. However, 2 days (...) (The Lancet 400, 10346 (2022))

7 July

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Correspondence] Breakthrough SARS-CoV-2 infections during periods of delta and omicron predominance, South Africa - Ameena Goga, Linda-Gail Bekker, Nigel Garrett, Tarylee Reddy, Nonhlanhla Yende-Zuma, Lara Fairall, Harry Moultrie, Azwidihwi Takalani, Valentina Trivella, Mark Faesen, Veronique Bailey, Ishen Seocharan, Glenda E Gray, Sisonke study team Lancet
  The omicron variant of SARS-CoV-2 (B.1.1.529) was first detected in South Africa in November, 2021.1–3 Declared a variant of concern on Nov 26, 2021,4 omicron spread exponentially, replacing the delta variant (B.1.617.2) and driving rapid increases in COVID-19 cases.5,6 In-vitro experiments show (...) (The Lancet 400, 10348 (2022))

2 July

Lancet https://www.thelancet.com/journals/lancet

• 00:00
  [Editorial] Ending child marriage: ensuring healthy futures for girls - The Lancet Lancet
  One in five women are married before the age of 18 years. This fact has serious ramifications for health and wellbeing. Child marriage is associated with pregnancy at a young age, dangerous complications during pregnancy and childbirth, HIV acquisition, and intimate partner violence. (...) (The Lancet 400, 10345 (2022))
• 00:00
  [Comment] Torus fractures of the distal radius: time to focus on symptomatic management - Kathy Boutis, Unni Narayanan Lancet
  The torus (buckle) fracture of the distal radius is one of the most common fractures in children. This fracture is inherently stable and carries an excellent prognosis,1 and several studies have supported the use of a removable splint primarily for symptom relief and discretionary follow-up.2–5 (...) (The Lancet 400, 10345 (2022))
• 00:00
  [Comment] WASH services and health: syntheses and contexts - Léo Heller Lancet
  An understanding of the associations between adequate water, sanitation, and hygiene (WASH) services and health has long been established, but gaps persist in the policy and research agenda.1 Effective policies require an intersectoral approach that encompasses health, WASH, and other areas, (...) (The Lancet 400, 10345 (2022))
• 00:00
  [Comment] A compassion narrative for the sustainable development goals: conscious and connected action - Liz Grant, Corinne Reid, Heather Buesseler, David Addiss Lancet
  At the midpoint of the 15-year timeline for achieving the UN Sustainable Development Goals (SDGs),1 the world is unprepared. The global community arguably has the scientific, technical, and political tools needed to achieve most, if not all, of the 169 SDG targets, yet we are far from the (...) (The Lancet 400, 10345 (2022))
• 00:00
  [Comment] Offline: Changing the argument for health - Richard Horton Lancet
  One institution that has thrived, despite the UK's reputational implosion (see last week's Offline), is Chatham House. Also known as the Royal Institute of International Affairs, Chatham House is a globally respected independent policy centre that conducts research, promotes dialogue, and (...) (The Lancet 400, 10345 (2022))
• 00:00
  [World Report] Federal abortion rights end, but not legal challenges - Susan Jaffe Lancet
  The US Supreme Court's decision to overturn Roe v Wade is due to spark further court cases. Susan Jaffe reports from Washington, DC. (The Lancet 400, 10345 (2022))
• 00:00
  [World Report] New declaration on neglected tropical diseases endorsed - Talha Burki Lancet
  Signatories reaffirmed their commitment to tackling neglected tropical diseases at a summit in Kigali, pledging US$4 billion. Talha Burki reports. (The Lancet 400, 10345 (2022))
• 00:00
  [World Report] New Zealand launches new M?ori health authority - Chris McCall Lancet
  The new body aims to tackle health inequities, but is proving politically divisive. Chris McCall reports. (The Lancet 400, 10345 (2022))
• 00:00
  [Perspectives] Digitising heart transplant rejection - Faisal Mahmood, Eric J Topol Lancet
  For more than four decades, the monitoring of cardiac allograft rejection (CAR) has been achieved by surveillance endomyocardial biopsies (EMBs) and manual assessment by cardiac pathology experts. The first criteria for histological assessment of EMBs were devised during the 1970s, and the (...) (The Lancet 400, 10345 (2022))
• 00:00
  [Perspectives] The journey to greater equality - Jayati Ghosh Lancet
  Economic inequalities have increased substantially across the world in the past three decades and have deepened during the COVID-19 pandemic. Thomas Piketty and his colleagues at the World Inequality Lab at the Paris School of Economics (PSE), France, have been at the forefront of tracking (...) (The Lancet 400, 10345 (2022))
• 00:00
  [Obituary] Morton Maimon Mower - Andrew Green Lancet
  Cardiologist and co-inventor of the automatic implantable cardioverter defibrillator. Born on Jan 31, 1933 in Baltimore, MD, USA, he died of cancer on April 25, 2022 in Denver, CO, USA, aged 89 years. (The Lancet 400, 10345 (2022))
• 00:00
  [Correspondence] Monkeypox genomic surveillance will challenge lessons learned from SARS-CoV-2 - Florian Pfaff, Donata Hoffmann, Martin Beer Lancet
  The emergence of a series of epidemiologically connected monkeypox virus infections around the world, with ongoing human-to-human transmission (as of June 15, 2022, 2103 confirmed cases, one probable case, and one death have been reported to WHO from 42 countries), raises concerns of a (...) (The Lancet 400, 10345 (2022))
• 00:00
  [Correspondence] The monkeypox outbreak is amplifying hidden voices in the global discourse - Aula Abbara, Bhargavi Rao, Boghuma K Titanji, Yap Boum, Alimuddin Zumla Lancet
  Tulio d Oliveira's Comment1 on the global inattention to infectious disease science done in Africa is timely, as the largest outbreak of monkeypox outside of Africa continues.2 As of June 15, 2022, 2103 laboratory-confirmed cases of monkeypox have been reported to WHO from 42 countries. The (...) (The Lancet 400, 10345 (2022))
• 00:00
  [Correspondence] Shifting gender barriers in immunisation in the COVID-19 pandemic response and beyond - Tiffany Nassiri-Ansari, Phionah Atuhebwe, Akosua Sika Ayisi, Sarah Goulding, Mira Johri, Pascale Allotey, Nina Schwalbe Lancet
  2 years into the COVID-19 pandemic, gender remains marginalised in the global vaccine response. As a stark example, of the 157 countries that reported on COVID-19 vaccine coverage to WHO in April, 2022, only 21 (13%) provided sex-disaggregated (...) (The Lancet 400, 10345 (2022))
• 00:00
  [Department of Error] Department of Error Lancet
  Li G, Cappuccini F, Marchevsky N G, et al. Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6–17 years: a preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial. Lancet 2022; 399: 2212–25—In this Article, in figure 2, “LI” has been (...) (The Lancet 400, 10345 (2022))
• 00:00
  [Articles] Immobilisation of torus fractures of the wrist in children (FORCE): a randomised controlled equivalence trial in the UK - Daniel C Perry, Juul Achten, Ruth Knight, Duncan Appelbe, Susan J Dutton, Melina Dritsaki, James M Mason, Damian T Roland, Shrouk Messahel, James Widnall, Matthew L Costa, FORCE Collaborators in collaboration with PERUKI Lancet
  This trial found equivalence in pain at 3 days in children with a torus fracture of the distal radius assigned to the offer of a bandage group or the rigid immobilisation group, with no between-group differences in pain or function during the 6 weeks of (...) (The Lancet 400, 10345 (2022))
• 00:00
  [Articles] Effectiveness of interventions to improve drinking water, sanitation, and handwashing with soap on risk of diarrhoeal disease in children in low-income and middle-income settings: a systematic review and meta-analysis - Jennyfer Wolf, Sydney Hubbard, Michael Brauer, Argaw Ambelu, Benjamin F Arnold, Robert Bain, Valerie Bauza, Joe Brown, Bethany A Caruso, Thomas Clasen, John M Colford, Matthew C Freeman, Bruce Gordon, Richard B Johnston, Andrew Mertens, Annette Prüss-Ustün, Ian Ross, Jeffrey Stanaway, Jeff T Zhao, Oliver Cumming, Sophie Boisson Lancet
  WASH interventions reduced risk of diarrhoea in children in LMICs. Interventions supplying either water filtered at POU, higher water quality from an improved source on premises, or basic sanitation services with sewer connection were associated with increased reductions. Our results support (...) (The Lancet 400, 10345 (2022))
• 00:00
  [Clinical Picture] Not all post-traumatic swellings are haematomas: be alert to a Morel-Lavallée lesion - Sohil Pothiawala, Rhian Miranda, Ian Civil Lancet
  A 34-year-old man was brought to our Emergency Department after a truck ran over the right side of his body while he was out walking. He had no medical history. (The Lancet 400, 10345 (2022))
• 00:00
  [Seminar] Complex post-traumatic stress disorder - Andreas Maercker, Marylene Cloitre, Rahel Bachem, Yolanda R. Schlumpf, Brigitte Khoury, Caitlin Hitchcock, Martin Bohus Lancet
  Complex post-traumatic stress disorder (complex PTSD) is a severe mental disorder that emerges in response to traumatic life events. Complex PTSD is characterised by three core post-traumatic symptom clusters, along with chronic and pervasive disturbances in emotion regulation, identity, and (...) (The Lancet 400, 10345 (2022))

1 July

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Correspondence] Clinical severity of omicron lineage BA.2 infection compared with BA.1 infection in South Africa - Nicole Wolter, Waasila Jassat, DATCOV-Gen author group, Anne von Gottberg, Cheryl Cohen Lancet
  The omicron SARS-CoV-2 variant of concern (B.1.1.529) was first reported in South Africa in mid-November, 2021. Early data indicated that infection with omicron (around 99% BA.1 lineage during this period) was associated with a lower risk of hospitalisation and lower risk of severe illness, (...) (The Lancet 400, 10346 (2022))
• 00:30
  [Comment] COVID-19 vaccination for children aged 5–11 years - Shamez N Ladhani Lancet
  COVID-19 vaccines have already prevented millions of deaths during the current pandemic.1 Given the strong association between increasing age and severe COVID-19 outcomes, adults were prioritised for vaccination when the first COVID-19 vaccines were authorised at the end of 2020.2 For children, (...) (The Lancet 400, 10346 (2022))
• 00:30
  [Articles] Effectiveness of BNT162b2 vaccine against SARS-CoV-2 infection and severe COVID-19 in children aged 5–11 years in Italy: a retrospective analysis of January–April, 2022 - Chiara Sacco, Martina Del Manso, Alberto Mateo-Urdiales, Maria Cristina Rota, Daniele Petrone, Flavia Riccardo, Antonino Bella, Andrea Siddu, Serena Battilomo, Valeria Proietti, Patrizia Popoli, Francesca Menniti Ippolito, Anna Teresa Palamara, Silvio Brusaferro, Giovanni Rezza, Patrizio Pezzotti, Massimo Fabiani, Italian National COVID-19 Integrated Surveillance System and the Italian COVID-19 vaccines registry Lancet
  Vaccination against COVID-19 in children aged 5–11 years in Italy showed a lower effectiveness in preventing SARS-CoV-2 infection and severe COVID-19 than in individuals aged 12 years and older. Effectiveness against infection appears to decrease after completion of the current primary (...) (The Lancet 400, 10346 (2022))

30 June

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Series] Improvement in trauma care for road traffic injuries: an assessment of the effect on mortality in low-income and middle-income countries - Junaid A Razzak, Junaid Bhatti, Kate Wright, Mulinda Nyirenda, Muhammad Ramzan Tahir, Adnan A Hyder Lancet
  Over 90% of the annual 1·35 million worldwide deaths due to road traffic injuries (RTIs) occur in low-income and middle-income countries (LMICs). For this Series paper, our aim was two-fold. Firstly, to review evidence on effective interventions for victims of RTIs; and secondly, to estimate the (...) (The Lancet 400, 10348 (2022))
• 00:30
  [Series] Saving lives through road safety risk factor interventions: global and national estimates - Andres I Vecino-Ortiz, Madhuram Nagarajan, Sarah Elaraby, Deivis Nicolas Guzman-Tordecilla, Nino Paichadze, Adnan A Hyder Lancet
  Global road mortality is a leading cause of death in many low-income and middle-income countries. Data to support priority setting under current resource constraints are urgently needed to achieve Sustainable Development Goal (SDG) 3.6. This Series paper estimates the potential number of lives (...) (The Lancet 400, 10347 (2022))
• 00:30
  [Correspondence] The fall of Roe v Wade: a call to action for religious medical providers - Sarrah Shahawy, Abbas Rattani Lancet
  On June 24, 2022, the Supreme Court of the USA overturned Roe v Wade, the culmination of a 5 decades-long effort to remove the strongest legal protection of abortion the USA has had thus far. The abortion discourse in the USA has been essentialised to a polarised debate, in which pro-life is (...) (The Lancet 400, 10346 (2022))
• 00:30
  [Series] The political and social contexts of global road safety: challenges for the next decade - Adnan A Hyder, Connie Hoe, Martha Hijar, Margaret Peden Lancet
  The goal of this Series paper is to show how road safety has evolved as a global public health issue over the past two decades and to discuss the political and economic dynamics that led to this change. Specifically, the key stakeholders, influences, networks, issue framing, actor power, and (...) (The Lancet 400, 10346 (2022))
• 00:30
  [Editorial] Road safety: more than reducing injuries - The Lancet Lancet
  The UN High-Level Meeting on global road safety (June 30–July 1) aims to put the issue on the highest political agenda. The need is huge. The global burden of road traffic injuries is estimated at an annual 1·35 million deaths, and 50 million injuries and disabilities. Road traffic injuries are (...) (The Lancet 400, 10346 (2022))

29 June

Lancet https://www.thelancet.com/journals/lancet

• 16:00
  [Comment] Tenecteplase for acute ischaemic stroke - Else Charlotte Sandset, Georgios Tsivgoulis Lancet
  The introduction of intravenous thrombolysis for acute ischaemic stroke has changed the outlook of stroke neurology, altering the field from a rehabilitation focus to emergency medicine. Because the treatment effect of intravenous thrombolysis in acute stroke is time dependent, stroke services (...) (The Lancet 400, 10347 (2022))
• 16:00
  [Articles] Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial - Bijoy K Menon, Brian H Buck, Nishita Singh, Yan Deschaintre, Mohammed A Almekhlafi, Shelagh B Coutts, Sibi Thirunavukkarasu, Houman Khosravani, Ramana Appireddy, Francois Moreau, Gord Gubitz, Aleksander Tkach, Luciana Catanese, Dar Dowlatshahi, George Medvedev, Jennifer Mandzia, Aleksandra Pikula, Jai Shankar, Heather Williams, Thalia S Field, Alejandro Manosalva, Muzaffar Siddiqui, Atif Zafar, Oje Imoukhuede, Gary Hunter, Andrew M Demchuk, Sachin Mishra, Laura C Gioia, Shirin Jalini, Caroline Cayer, Stephen Phillips, Elsadig Elamin, Ashkan Shoamanesh, Suresh Subramaniam, Mahesh Kate, (...) Lancet
  Intravenous tenecteplase (0·25 mg/kg) is a reasonable alternative to alteplase for all patients presenting with acute ischaemic stroke who meet standard criteria for thrombolysis. (The Lancet 400, 10347 (2022))
• 11:00
  [Comment] Istanbul Protocol 2022 empowers health professionals to end torture - Vincent Iacopino, Rohini J Haar, Michele Heisler, James Lin, ?ebnem Korur Fincanc?, Chris Esdaile, Jens Modvig, Nora Sveaass, Vivienne H Nathanson, Nils Melzer, Juliet Cohen Lancet
  Torture, one of the most heinous crimes known to humanity, inflicts profound harms on individuals and threatens the health, dignity, and wellbeing of families and communities. Health professionals have a duty both to document torture and to protect human rights as a foundation for human health (...) (The Lancet 400, 10347 (2022))

28 June

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Reducing the threat of epidemic-prone infections at mass gathering religious events - Alimuddin Zumla, Tieble Traore, Lateefat Amao, Francine Ntoumi, Avinash Sharma, Esam I Azhar, Aula Abbara Lancet
  Mass gathering sporting, religious, festival, and celebratory events attract people from across the world and create optimal conditions for the transmission of a range of infectious diseases with epidemic potential.1 Countries hosting recurrent annual religious pilgrimages that cater for (...) (The Lancet 400, 10346 (2022))

25 June

Lancet https://www.thelancet.com/journals/lancet

• 00:00
  [Editorial] Cancer care: widening the scope of innovation - The Lancet Lancet
  The keynote address at the 2022 American Society of Clinical Oncology (ASCO) meeting earlier in June was met with great enthusiasm. André Ilbawi, WHO's Cancer Control Officer, announced the first partnership between ASCO and WHO that, he says, “catalyses meaningful innovation to address (...) (The Lancet 399, 10344 (2022))
• 00:00
  [Comment] Early introduction of allergenic food for all infants - Michael R Perkin Lancet
  The 2015 Learning Early About Peanut Allergy (LEAP) study triggered a paradigm shift in the field of food allergy prevention from an understanding that, in infants at high risk of developing a peanut allergy, prevention was best achieved by peanut avoidance to active early peanut consumption.1 (...) (The Lancet 399, 10344 (2022))
• 00:00
  [Comment] The 2022 Wakley Prize: compassion and connection - Jessamy Bagenal, Benjamin Burlton, Florence Costalas, Bethany Gomersall, Joanna Palmer, Paula Preyzner Lancet
  During the COVID-19 pandemic health professionals have found themselves working in a landscape that has been utterly transformed, for good and ill. There have been remarkable advances, such as accelerated research to produce effective treatments and vaccines, and increased use of digital health (...) (The Lancet 399, 10344 (2022))
• 00:00
  [Comment] Sharpening the focus on powerful health stories: Highlights 2022 photography competition open for submissions - Joanna Palmer Lancet
  Syrian photographer Sameer Al-Doumy's photograph of two boys playing on swings in Douma, Eastern Ghouta, Syria, on the first day of a ceasefire in February, 2016, captures a moment of happiness and release amid years of conflict.1 Some 2 months later, a photograph by Karam al-Masri, taken after (...) (The Lancet 399, 10344 (2022))
• 00:00
  [Comment] Offline: The UK, a knave among nations - Richard Horton Lancet
  In 2015, the All-Party Parliamentary Group (APPG) on Global Health published an admiring report, The UK's Contribution to Health Globally—Benefiting the Country and the World. They identified four sectors where Britain added important value. The UK had shown consistent global leadership towards (...) (The Lancet 399, 10344 (2022))
• 00:00
  [World Report] Nominees to lead PAHO announced - Amy Booth Lancet
  Amy Booth spoke with the candidates about their priorities and their vision for the future of the Pan American Health Organization. (The Lancet 399, 10344 (2022))
• 00:00
  [World Report] COVID-19 in North Korea - Talha Burki Lancet
  1 month ago, North Korea declared its first COVID-19 cases. Information is scare, but the outbreak now appears to be huge, amid a food crisis and without mass vaccination. Talha Burki reports. (The Lancet 399, 10344 (2022))
• 00:00
  [Perspectives] Naomi Oreskes: understanding the denial of science - Aarathi Prasad Lancet
  Social responses to anthropogenic climate change and the role of science in society are key concerns for Naomi Oreskes, Henry Charles Lea Professor of the History of Science and Affiliated Professor of Earth and Planetary Sciences at Harvard University, Cambridge, MA, USA. In her academic work (...) (The Lancet 399, 10344 (2022))
• 00:00
  [Perspectives] General practice: a fortunate profession? - Gavin Francis Lancet
  A Fortunate Man is a classic of photojournalism, published in 1967 by the art writer John Berger with the photographer Jean Mohr. The book examines the work of Dr John “Sassall”, a friend of Berger and Mohr and a general practitioner (GP) in the Forest of Dean, Wye Valley, UK. For 6 weeks in the (...) (The Lancet 399, 10344 (2022))
• 00:00
  [Obituary] Aaron T Beck - Andrew Green Lancet
  Psychiatrist who pioneered cognitive therapy. Born on July 18, 1921 in Providence, RI, USA, he died on Nov 1, 2021 in Philadelphia, PA, USA, aged 100 years. (The Lancet 399, 10344 (2022))
• 00:00
  [Correspondence] Global burden of antimicrobial resistance: essential pieces of a global puzzle - Esmita Charani, Martin McKee, Manica Balasegaram, Marc Mendelson, Sanjeev Singh, Alison H Holmes Lancet
  Christopher J L Murray and colleagues1 provide a compelling contribution to the understanding of the burden of disease attributable to bacterial antimicrobial resistance (AMR) in 2019. Focusing on 23 bacterial pathogens, they used two-stage spatiotemporal modelling to estimate this burden to be (...) (The Lancet 399, 10344 (2022))
• 00:00
  [Correspondence] Global burden of antimicrobial resistance: essential pieces of a global puzzle - Marlieke E A de Kraker, Stephan Harbarth Lancet
  Christopher J L Murray and colleagues1 highlight the global impact of the silent antimicrobial resistance (AMR) pandemic. The applied methodology is more thorough than previous efforts,2 but there are a number of important limitations. (The Lancet 399, 10344 (2022))
• 00:00
  [Correspondence] Global burden of antimicrobial resistance: essential pieces of a global puzzle - Timothy R Walsh, Rabaab Zahra, Kenneth Iregbu, Sharon J Peacock, Andrew Stewardson Lancet
  Christopher J L Murray and colleagues1 provide a sobering analysis on the burden of common antimicrobial-resistant infections and a warning that, as a global community, we are rapidly surrendering any advantage we had on treating infections such as pneumonia and (...) (The Lancet 399, 10344 (2022))
• 00:00
  [Correspondence] Global burden of antimicrobial resistance: essential pieces of a global puzzle - Denis Mukwege, Prudence Mitangala, Aline Byabene, Emmanuel Busha, Yves Van Laethem, Olivier Vandenberg Lancet
  Christopher J L Murray and colleagues1 report on the dramatically high burden of antimicrobial resistance (AMR) worldwide, particularly in low-income and middle-income countries. The authors also emphasise the insufficient data on the prevalence of bacterial infections and AMR in low-resource (...) (The Lancet 399, 10344 (2022))
• 00:00
  [Correspondence] Global burden of antimicrobial resistance: essential pieces of a global puzzle - Diane Ashiru-Oredope, Maxencia Nabiryo, Eva M Krockow, Sabiha Essack Lancet
  Christopher J L Murray and colleagues1 evidence the global burden of antimicrobial resistance (AMR), which disproportionally affects low-income and middle-income countries (LMICs). (The Lancet 399, 10344 (2022))
• 00:00
  [Correspondence] Global burden of antimicrobial resistance: essential pieces of a global puzzle – Authors' reply - Mohsen Naghavi, Christopher J L Murray, Kevin S Ikuta, Tomislav Mestrovic, Lucien Swetschinski, Benn Sartorius Lancet
  We thank Esmita Charani and colleagues, Marlieke E A de Kraker and Stephan Harbarth, Timothy R Walsh and colleagues, Denis Mukwege and colleagues, and Diane Ashiru-Oredope and colleagues for their interest in our work1 and insightful comments that will improve the quality of our estimation (...) (The Lancet 399, 10344 (2022))
• 00:00
  [Articles] Early food intervention and skin emollients to prevent food allergy in young children (PreventADALL): a factorial, multicentre, cluster-randomised trial - Håvard Ove Skjerven, Anine Lie, Riyas Vettukattil, Eva Maria Rehbinder, Marissa LeBlanc, Anna Asarnoj, Kai-Håkon Carlsen, Åshild Wik Despriee, Martin Färdig, Sabina Wärnberg Gerdin, Berit Granum, Hrefna Katrín Gudmundsdóttir, Guttorm Haugen, Gunilla Hedlin, Geir Håland, Christine Monceyron Jonassen, Linn Landrø, Caroline-Aleksi Olsson Mägi, Inge Christoffer Olsen, Knut Rudi, Carina Madelen Saunders, Marius Kurås Skram, Anne Cathrine Staff, Cilla Söderhäll, Sandra G Tedner, Sigve Aadalen, Hilde Aaneland, Björn Nordlund, Karin C Lødrup (...) Lancet
  Exposure to allergenic foods from 3 months of age reduced food allergy at 36 months in a general population. Our results support that early introduction of common allergenic foods is a safe and effective strategy to prevent food (...) (The Lancet 399, 10344 (2022))
• 00:00
  [Clinical Picture] Continuous glucose monitoring device causes consternation on chest x-ray - Phoebe Wing-Lam Ho, Cheuk-Chun Szeto, Kai-Ming Chow Lancet
  An 80-year-old man was admitted to our hospital with chest pain and shortness of breath. (The Lancet 399, 10344 (2022))

23 June

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] The UK benefits from a truly National Health Service - Eddie Barnes, Gordon Brown, David J Kerr Lancet
  Devolution is about how parliaments and governments make decisions. In the UK, separate legislatures and executives in Scotland, Wales, and Northern Ireland have many powers to make laws and deliver public services. One of the dominant institutions in Scotland, which is seen as both (...) (The Lancet 400, 10346 (2022))

22 June

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Correspondence] Guidelines for pregnant individuals with monkeypox virus exposure - Pradip Dashraath, Karin Nielsen-Saines, Citra Mattar, Didier Musso, Paul Tambyah, David Baud Lancet
  On May 21, 2022, WHO reported an emerging global outbreak of monkeypox virus infection, with documented community transmission among people in contact with symptomatic cases in non-endemic countries. (The Lancet 400, 10345 (2022))

18 June

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Partnering to deliver sustainable children's surgical care in Kakuma refugee camp - Neema Kaseje, Khalid Hassan, Jesse Muriithi, John Burton, Benjamin Weswa, Kefa Ojwando, Collins Chirchir, Stephen Kinara, David Cunningham, Stephen Okelo Lancet
  The devastating milestone of 100 million people globally forced to flee their homes because of war, violence, persecution, and discrimination was reached on May 23, 2022.1 Women and children are disproportionately affected. 42% of forcibly displaced people worldwide are children.2 In Kenya, by (...) (The Lancet 401, 10374 (2023))
• 00:00
  [Editorial] Attitudes towards menopause: time for change - The Lancet Lancet
  In this week's issue of The Lancet, a Comment by Zoe Schaedel and Janice Ryder highlights many of the misconceptions around, and barriers to, menopause care. Stigma, embarrassment, a lack of public awareness, and miscommunication mean that for many women, menopause is either borne in quiet (...) (The Lancet 399, 10343 (2022))
• 00:00
  [Comment] Relugolix combination therapy for endometriosis pain - Lucky Saraswat, Siladitya Bhattacharya Lancet
  The treatment of endometriosis-associated pain continues to be a major problem for women and their clinicians.1,2 Laparoscopy, required to confirm the diagnosis, is usually combined with surgical ablation or excision of endometriotic lesions to alleviate pain and hormonal contraceptives are (...) (The Lancet 399, 10343 (2022))
• 00:00
  [Comment] Opioid-free analgesia after surgery - Paul S Myles, Thuy Bui Lancet
  Acute pain is near universal after surgery. Opioids have been a mainstay of postoperative analgesia, but current best practice emphasises a multimodal opioid-sparing regimen based on a background of paracetamol, a non-steroidal anti-inflammatory drug, or both.1 Opioids are frequently overused, (...) (The Lancet 399, 10343 (2022))
• 00:00
  [Comment] Second-line CAR T cells for lymphomas - Alberto Mussetti, Anna Sureda Lancet
  Anti-CD19 chimeric antigen receptor (CAR) T cells have shown huge therapeutical potential in the treatment of aggressive B-cell lymphomas beyond second-line of therapy.1–3 But the use of such therapies as a second-line of therapy is a current matter of debate. At the 2021 American Society of (...) (The Lancet 399, 10343 (2022))
• 00:00
  [Comment] Offline: WHO's hits and misses for mental health - Richard Horton Lancet
  There are few truly watershed moments in medicine and global health. But the publication this month of WHO's World Mental Health Report is one such milestone. It is the agency's first major global foray into mental health for over two decades. Led by Dévora Kestel, who directs the Department of (...) (The Lancet 399, 10343 (2022))
• 00:00
  [World Report] Investigating monkeypox - Talha Burki Lancet
  Monkeypox was discovered in 1958, but scientists are now looking for answers to new questions raised by its continued global spread. Talha Burki reports. (The Lancet 399, 10343 (2022))
• 00:00
  [World Report] Poland to introduce controversial pregnancy register - Ed Holt Lancet
  Members of Parliament and activists have criticised the law, with fears that women might avoid seeking health care. Ed Holt reports. (The Lancet 399, 10343 (2022))
• 00:00
  [World Report] UK scientists warn over threat to Horizon funding - Udani Samarasekera Lancet
  Disagreement over Brexit has left the UK facing being cut off from the world's largest research funding programme. Udani Samarasekera reports. (The Lancet 399, 10343 (2022))
• 00:00
  [Perspectives] Psychiatry in crisis: great expectations, elusive cures - Vivian B Pender Lancet
  There is no denying an ongoing crisis in mental health. For individuals and those around them, persistent mental illness can have devastating impacts. Yet, there is a substantial gap between people who need mental health care and access to effective treatment. Even when psychiatric care is (...) (The Lancet 399, 10343 (2022))
• 00:00
  [Perspectives] Memorialising COVID-19 - Danielle Ofri Lancet
  The notifications are more than 2 years old by now, but I still cannot bring myself to delete them from my hospital's electronic medical record (EMR). There is the “expiration alert” that signalled my very first patient to die of COVID-19—a chipper Ecuadorian who had spent months struggling to (...) (The Lancet 399, 10343 (2022))
• 00:00
  [Obituary] Ursula Bellugi - Geoff Watts Lancet
  Neurobiologist who studied Williams syndrome. She was born in Jena, Germany, on Feb 21, 1931 and died in La Jolla, CA, USA, on April 17, 2022 aged 91 years. (The Lancet 399, 10343 (2022))
• 00:00
  [Correspondence] Risk of long COVID associated with delta versus omicron variants of SARS-CoV-2 - Michela Antonelli, Joan Capdevila Pujol, Tim D Spector, Sebastien Ourselin, Claire J Steves Lancet
  The omicron variant of SARS-CoV-2 (PANGO B.1.1.529) spread rapidly across the world, out-competing former variants soon after it was first detected in November, 2021. According to the Our World in Data COVID-19 database, In Europe, the number of confirmed cases reported between December, 2021, (...) (The Lancet 399, 10343 (2022))
• 00:00
  [Correspondence] Gender equality and climate action: lessons from evidence on SRHR - Johanna Riha, Anju Malhotra, Ayomide Oluseye Lancet
  Following the successful Lancet webinar on gender and sustainability, the Lancet Editorial1 on planetary health serves as an important reminder of how essential it is to address gender inequalities for ensuring a healthy planet. In addition to areas for action that the webinar and subsequent (...) (The Lancet 399, 10343 (2022))
• 00:00
  [Correspondence] Where are the children and adolescents? - Mark Tomlinson Lancet
  Despite publishing a key WHO–UNICEF–Lancet Commission1 that made the case for putting children and adolescents at the centre of our thinking, an Editorial commemorating World Health Day 2022 did not mention children or adolescents.2 (The Lancet 399, 10343 (2022))
• 00:00
  [Correspondence] Supporting cancer survivors in LMICs - Yek-Ching Kong, Michelle Ann Eala, Nirmala Bhoo Pathy Lancet
  The Editors discuss unmet needs of the growing population of cancer survivors.1 Cancer survival rates in many low-income and middle-income countries (LMICs) have seen a rise in the past two decades.2 Amid the increasing number of people surviving cancer, cancer control efforts in these settings (...) (The Lancet 399, 10343 (2022))
• 00:00
  [Department of Error] Department of Error Lancet
  Zarocostas J. WHA sees changes to health regulations and WHO funding. Lancet 2022; 399: 2090–91—This World Report should have stated that Dr Tedros did not have the support of Ethiopia in his re-election. This change has been made to the online version as of June 16, (...) (The Lancet 399, 10343 (2022))
• 00:00
  [Articles] Once daily oral relugolix combination therapy versus placebo in patients with endometriosis-associated pain: two replicate phase 3, randomised, double-blind, studies (SPIRIT 1 and 2) - Linda C Giudice, Sawsan As-Sanie, Juan C Arjona Ferreira, Christian M Becker, Mauricio S Abrao, Bruce A Lessey, Eric Brown, Krzysztof Dynowski, Krzysztof Wilk, Yulan Li, Vandana Mathur, Qurratul Ann Warsi, Rachel B Wagman, Neil P Johnson Lancet
  Once-daily relugolix combination therapy significantly improved endometriosis-associated pain and was well tolerated. This oral therapy has the potential to address the unmet clinical need for long-term medical treatment for endometriosis, reducing the need for opioid use or repeated surgical (...) (The Lancet 399, 10343 (2022))
• 00:00
  [Articles] Opioid versus opioid-free analgesia after surgical discharge: a systematic review and meta-analysis of randomised trials - Julio F Fiore, Charbel El-Kefraoui, Marc-Aurele Chay, Philip Nguyen-Powanda, Uyen Do, Ghadeer Olleik, Fateme Rajabiyazdi, Araz Kouyoumdjian, Alexa Derksen, Tara Landry, Alexandre Amar-Zifkin, Amy Bergeron, Agnihotram V Ramanakumar, Marc Martel, Lawrence Lee, Gabriele Baldini, Liane S Feldman Lancet
  Findings from this meta-analysis support that opioid prescribing at surgical discharge does not reduce pain intensity but does increase adverse events. Evidence relied on trials focused on elective surgeries of minor and moderate extent, suggesting that clinicians can consider prescribing (...) (The Lancet 399, 10343 (2022))
• 00:00
  [Articles] Lisocabtagene maraleucel versus standard of care with salvage chemotherapy followed by autologous stem cell transplantation as second-line treatment in patients with relapsed or refractory large B-cell lymphoma (TRANSFORM): results from an interim analysis of an open-label, randomised, phase 3 trial - Manali Kamdar, Scott R Solomon, Jon Arnason, Patrick B Johnston, Bertram Glass, Veronika Bachanova, Sami Ibrahimi, Stephan Mielke, Pim Mutsaers, Francisco Hernandez-Ilizaliturri, Koji Izutsu, Franck Morschhauser, Matthew Lunning, David G Maloney, Alessandro Crotta, Sandrine Montheard, Alessandro Previtali, Lara Stepan, Ken Ogasawara, Timothy Mack, Jeremy S Abramson, TRANSFORM Investigators Lancet
  These results support liso-cel as a new second-line treatment recommendation in patients with early relapsed or refractory LBCL. (The Lancet 399, 10343 (2022))
• 00:00
  [Clinical Picture] Bilateral renal lymphangiomatosis causes swelling and lower back pain - Cécile Manceau, Séverine Lagarde, Sarah Pericart, Xavier Gamé Lancet
  A 19-year-old woman was referred to the emergency unit with a 1-month history of increasing bilateral pain and swelling in her lower back; she reported that the symptoms had recently become worse. The patient did not have a fever and had no recent (...) (The Lancet 399, 10343 (2022))

17 June

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Articles] Life expectancy by county, race, and ethnicity in the USA, 2000–19: a systematic analysis of health disparities - GBD US Health Disparities Collaborators Lancet
  Disparities in life expectancy among racial–ethnic groups are widespread and enduring. Local-level data are crucial to address the root causes of poor health and early death among disadvantaged groups in the USA, eliminate health disparities, and increase longevity for (...) (The Lancet 400, 10345 (2022))
• 00:30
  [Comment] Data aggregation hides Pacific Islander health disparities - Kekoa Taparra, Karen Pellegrin Lancet
  Meaningful measures of health disparities are needed to both motivate and monitor progress, but the accuracy of life expectancy estimates has been questioned, owing to misreporting of race and ethnicity and to small populations at the local level. In The Lancet, the GBD US Health Disparities (...) (The Lancet 400, 10345 (2022))

16 June

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [World Report] Fears for Iranian-Swedish doctor held on espionage charges - Sharmila Devi Lancet
  Ahmadreza Djalali was due to be executed last month. After an apparently successful appeal, rights groups and health organisations are calling for his release. Sharmila Devi reports. (The Lancet 399, 10344 (2022))
• 00:30
  [Correspondence] Monkeypox in the UK: arguments for a broader case definition - Daniel Pan, Shirley Sze, Joshua Nazareth, Christopher A Martin, Amani Al-Oraibi, Rebecca F Baggaley, Laura B Nellums, T Déirdre Hollingsworth, Julian W Tang, Manish Pareek Lancet
  Monkeypox cases are increasing rapidly in the UK. The UK Health and Safety Agency (UKHSA) defines a probable case of monkeypox as “a person with an unexplained rash on any part of their body plus one or more classical symptom or symptoms of monkeypox infection since March 15, 2022 and either: (...) (The Lancet 399, 10344 (2022))

11 June

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Correspondence] The Palestinian people: erased from World Health Statistics - Rita H Giacaman, Weeam Hammoudeh, Ramadan Hamed Mohamed, Iman Nuwayhid, Hoda Rashad, Luay Shabaneh, Huda Zurayk Lancet
  WHO headquarters' erasure of the Palestinian people from World Health Statistics 2022 and previous issues of World Health Statistics, as noted by Richard Horton,1 is both unacceptable and insulting. This needs to be addressed and remedied as soon as (...) (The Lancet 399, 10343 (2022))
• 00:00
  [Editorial] Mental health after China's prolonged lockdowns - The Lancet Lancet
  On June 1, Shanghai reopened after a 2-month lockdown to curb COVID-19. On June 6, Beijing also eased COVID-19 restrictions by allowing restaurant dining and the gradual reopening of schools from June 13 in most districts. Although many countries instituted various forms of lockdown over the (...) (The Lancet 399, 10342 (2022))
• 00:00
  [Comment] COVID-19 mRNA vaccination and myocarditis or pericarditis - Anders Husby, Lars Køber Lancet
  In April, 2021, international news media first reported rare cases of young men in Israel who had developed myocarditis shortly after vaccination with the Pfizer-BioNTech mRNA vaccine against SARS-CoV-2.1 Since then, many observational studies from Asia,2 Europe,3–5 the Middle East,6,7 and North (...) (The Lancet 399, 10342 (2022))
• 00:00
  [Comment] Head-to-head biologic therapy in Crohn's disease - Thomas P Chapman, Jack Satsangi Lancet
  The therapeutic armamentarium for the chronic inflammatory bowel diseases—Crohn's disease and ulcerative colitis—is rapidly expanding, yet treatment failure remains common, with substantial impact upon patients’ quality of life and health-care costs, including hospitalisation and surgery.1 There (...) (The Lancet 399, 10342 (2022))
• 00:00
  [Comment] Increasing children's global access to COVID-19 vaccines - Manish Patel, Minal Patel Lancet
  Expanding COVID-19 vaccination to children is an issue for parents and decision makers worldwide. Among nine vaccines with WHO Emergency Use Listing (EUL), only two are authorised for children: Pfizer-BioNTech's BNT162b2 and Moderna's mRNA-1273.1 The WHO EUL is required for vaccines purchased (...) (The Lancet 399, 10342 (2022))
• 00:00
  [Comment] Offline: Why science is not enough - Richard Horton Lancet
  “Listen to the science.” The distinguished climate scientist, Thomas Stocker, was speaking at the Science7 Dialogue Forum in Berlin, Germany, on May 31, 2022. The occasion was the publication of statements from the science academies of G7 nations on antiviral drugs for pandemic preparedness, (...) (The Lancet 399, 10342 (2022))
• 00:00
  [World Report] US infant formula crisis increases scrutiny of the FDA - Susan Jaffe Lancet
  Both Republican and Democrat legislators have called for changes following a shortage of breastmilk substitute. Susan Jaffe reports from Washington, DC. (The Lancet 399, 10342 (2022))
• 00:00
  [World Report] Waiting for France's turn towards preventive health care - Ferry Biedermann Lancet
  Health has been designated a priority by the French government, with an emphasis on disease prevention. Ferry Biedermann reports. (The Lancet 399, 10342 (2022))
• 00:00
  [Perspectives] Lola Kola: developing mHealth for mental health in west Africa - Udani Samarasekera Lancet
  Lola Kola's passion is global mental health research that harnesses the potential “of psychological interventions for improving outcomes for patients when delivered by trained lay health-care workers” and “the use of technology to support the delivery of such interventions”, she says. Based in (...) (The Lancet 399, 10342 (2022))
• 00:00
  [Perspectives] Excavating and deciphering Tutankhamun - Andrew Robinson Lancet
  A tantalising monochrome photograph of Tutankhamun's burial chamber in Egypt's Valley of the Kings compels attention in Tutankhamun: Excavating the Archive. This exhibition and accompanying book revitalise the legendary 1920s archaeological discovery, using original excavation documents (...) (The Lancet 399, 10342 (2022))
• 00:00
  [Perspectives] Obstetric violence in historical perspective - Elizabeth O’Brien, Miriam Rich Lancet
  Although improvements in perinatal care have helped save many lives worldwide, reproductive health inequities remain rife. Racial, geographical, and class-based disparities shape divergent maternal and infant health outcomes, as well as unequal access to vital forms of health care such as (...) (The Lancet 399, 10342 (2022))
• 00:00
  [Obituary] Arthur Dale Riggs - Geoff Watts Lancet
  Biochemist who developed synthetic human insulin. He was born in Modesto, CA, USA, on Aug 8, 1939 and died of lymphoma in Duarte, CA, USA, on March 23, 2022 aged 82 years. (The Lancet 399, 10342 (2022))
• 00:00
  [Correspondence] Preparing for what we abhor: an obligation of public health professionals - Henrique Lopes, John Middleton, Oliver Razum Lancet
  The current war in Europe has increased the threats to population health, including the possible use of atomic and chemical weapons. We are entering the reality of nuclear, chemical, and biological warfare. (The Lancet 399, 10342 (2022))
• 00:00
  [Correspondence] The value of oral care in dying and death - Frank Lobbezoo, Ghizlane Aarab, Merel C Verhoeff, Catherine M C Volgenant Lancet
  The focus on dying and death has been revived. The Lancet Commission on the value of death states that dying and death should be recognised as normal and, especially, meaningful: there is no life without death.1 To this end, end-of-life care ought to be available to all, with a shift in (...) (The Lancet 399, 10342 (2022))
• 00:00
  [Correspondence] The hijacking of science and truth by political conflict - Hélio Angotti Neto Lancet
  Luis L C Correia and colleagues 1 filled their Correspondence with malicious and false information. Although they claimed to have no competing interests, at least two of them were directly involved in the approval of the recommendations proposed in the Brazilian guideline for COVID-19 (...) (The Lancet 399, 10342 (2022))
• 00:00
  [Correspondence] Opportunities for women's health in the first postnatal year - Jane E Hirst, Nicole Votruba, Ian M Bennett, J Jaime Miranda, Pallab K Maulik Lancet
  The Lancet Commission on depression by Helen Herrman and colleagues1 highlights the importance of life stages for depression, the first of which is the perinatal period, defined as pregnancy and the first 6 weeks after birth. However, the Commission's recommendations miss the crucial importance (...) (The Lancet 399, 10342 (2022))
• 00:00
  [Correspondence] Obesity definition for personalised treatment of type 2 diabetes - Rajna Golubic, Thomas M Barber, Rishi Caleyachetty Lancet
  We read with interest the Review by Ildiko Lingvay and colleagues,1 which refocused the treatment of type 2 diabetes to weight management as the primary goal. We agree that obesity should be viewed as the main target to address in both prevention and care of type 2 diabetes, but addressing (...) (The Lancet 399, 10342 (2022))
• 00:00
  [Correspondence] Obesity definition for personalised treatment of type 2 diabetes Authors’ reply - Ildiko Lingvay, Priya Sumithran, Ricardo V Cohen, Carel W le Roux Lancet
  We thank Rajna Golubic and colleagues for their Correspondence regarding our Review1 in which they remind us of the challenges of identifying individuals who benefit most from weight loss interventions and for highlighting the adiposity-based chronic disease framework as an alternative to (...) (The Lancet 399, 10342 (2022))
• 00:00
  [Department of Error] Department of Error Lancet
  Rearte A, Castelli JM, Rearte R, et al. Effectiveness of rAd26-rAd5, ChAdOx1 nCoV-19, and BBIBP-CorV vaccines for risk of infection with SARS-CoV-2 and death due to COVID-19 in people older than 60 years in Argentina: a test-negative, case-control, and retrospective longitudinal study. Lancet (...) (The Lancet 399, 10342 (2022))
• 00:00
  [Articles] Risk of myocarditis and pericarditis after the COVID-19 mRNA vaccination in the USA: a cohort study in claims databases - Hui-Lee Wong, Mao Hu, Cindy Ke Zhou, Patricia C Lloyd, Kandace L Amend, Daniel C Beachler, Alex Secora, Cheryl N McMahill-Walraven, Yun Lu, Yue Wu, Rachel P Ogilvie, Christian Reich, Djeneba Audrey Djibo, Zhiruo Wan, John D Seeger, Sandia Akhtar, Yixin Jiao, Yoganand Chillarige, Rose Do, John Hornberger, Joyce Obidi, Richard Forshee, Azadeh Shoaibi, Steven A Anderson Lancet
  An increased risk of myocarditis or pericarditis was observed after COVID-19 mRNA vaccination and was highest in men aged 18–25 years after a second dose of the vaccine. However, the incidence was rare. These results do not indicate a statistically significant risk difference between mRNA-1273 (...) (The Lancet 399, 10342 (2022))
• 00:00
  [Articles] Ustekinumab versus adalimumab for induction and maintenance therapy in biologic-naive patients with moderately to severely active Crohn's disease: a multicentre, randomised, double-blind, parallel-group, phase 3b trial - Bruce E Sands, Peter M Irving, Timothy Hoops, James L Izanec, Long-Long Gao, Christopher Gasink, Andrew Greenspan, Matthieu Allez, Silvio Danese, Stephen B Hanauer, Vipul Jairath, Tanja Kuehbacher, James D Lewis, Edward V Loftus, Emese Mihaly, Remo Panaccione, Ellen Scherl, Oksana B Shchukina, William J Sandborn, SEAVUE Study Group Lancet
  Both ustekinumab and adalimumab monotherapies were highly effective in this population of biologic-naive patients, with no difference in the primary outcome between the drugs. (The Lancet 399, 10342 (2022))
• 00:00
  [Articles] Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6–17 years: a preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial - Grace Li, Federica Cappuccini, Natalie G Marchevsky, Parvinder K Aley, Robert Aley, Rachel Anslow, Sagida Bibi, Katrina Cathie, Elizabeth Clutterbuck, Saul N Faust, Shuo Feng, Paul T Heath, Simon Kerridge, Alice Lelliott, Yama Mujadidi, Khuen Foong Ng, Sarah Rhead, Hannah Roberts, Hannah Robinson, Marion R Roderick, Nisha Singh, David Smith, Matthew D Snape, Rinn Song, Karly Tang, Andy Yao, Xinxue Liu, Teresa Lambe, Andrew J Pollard, the COV006 study (...) Lancet
  ChAdOx1 nCoV-19 is well tolerated and immunogenic in children aged 6–17 years, inducing concentrations of antibody that are similar to those associated with high efficacy in phase 3 studies in adults. No safety concerns were raised in this (...) (The Lancet 399, 10342 (2022))
• 00:00
  [Clinical Picture] The changing face of Klebsiella pneumoniae carbapenemase: in-vivo mutation in patient with chest infection - Siquan Shen, Qingyu Shi, Fupin Hu Lancet
  A 52-year-old woman with a 10-day history of a fever and who had, for the past 4 days, an impaired level of consciousness attended our hospital. (The Lancet 399, 10342 (2022))

10 June

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Seminar] Coeliac disease - Carlo Catassi, Elena F Verdu, Julio Cesar Bai, Elena Lionetti Lancet
  Coeliac disease is an autoimmune disorder that primarily affects the small intestine, and is caused by the ingestion of gluten in genetically susceptible individuals. Prevalence in the general population ranges from 0·5% to 2%, with an average of about 1%. The development of the coeliac (...) (The Lancet 399, 10344 (2022))
• 00:30
  [Seminar] Thalassaemia - Antonis Kattamis, Janet L Kwiatkowski, Yesim Aydinok Lancet
  Thalassaemia is a diverse group of genetic disorders with a worldwide distribution affecting globin chain synthesis. The pathogenesis of thalassaemia lies in the unbalanced globin chain production, leading to ineffective erythropoiesis, increased haemolysis, and deranged iron homoeostasis. The (...) (The Lancet 399, 10343 (2022))
• 00:30
  [Correspondence] Hunting down the cause of acute hepatitis in children - Anil Dhawan, Sunitha Vimalesvaran Lancet
  As of May 16, 2022, the UK has seen 197 cases of non-A–E acute hepatitis in children younger than 16 years, 11 of whom have needed liver transplantation; no deaths have been reported thus far.1 (The Lancet 399, 10343 (2022))

4 June

Lancet https://www.thelancet.com/journals/lancet

• 00:00
  [Editorial] Gun violence in the USA: children's right to health - The Lancet Lancet
  An epidemic of preventable violence is killing and harming Americans—especially, children and adolescents. On May 24, an 18-year-old man killed 19 children and two adults in Robb Elementary School in Uvalde, Texas. As the world mourns for the US and its children, the familiar cycle of grief, (...) (The Lancet 399, 10341 (2022))
• 00:00
  [Comment] Incidence of perforation with intrauterine devices - Deborah Bartz Lancet
  When available and used properly, intrauterine devices (IUDs) are near-perfect birth control as they provide highly effective protection against pregnancy with minimal to no adverse systemic side effects. Therefore, patient satisfaction rates are high.1 Given these successes, IUD provision has (...) (The Lancet 399, 10341 (2022))
• 00:00
  [Comment] Offline: WHO's erasure of Palestinians must cease - Richard Horton Lancet
  Global health is a graveyard of good intentions. WHO's Director-General, Tedros Adhanom Ghebreyesus, gave a widely admired address to the World Health Assembly last week. He spoke of “the profound consequences of conflict” for health and concluded his speech with these words: “Unless we seek (...) (The Lancet 399, 10341 (2022))
• 00:00
  [World Report] WHA sees changes to health regulations and WHO funding - John Zarocostas Lancet
  A landmark decision has been made at the World Health Assembly on sustainable financing to help enhance the independence of WHO in global health. John Zarocostas reports from Geneva. (The Lancet 399, 10341 (2022))
• 00:00
  [World Report] Nigeria's new law aims to provide health insurance to all - Paul Adepoju Lancet
  In Nigeria, where only 3% of the population has health insurance coverage, a new law has been signed to provide coverage for all. Paul Adepoju reports. (The Lancet 399, 10341 (2022))
• 00:00
  [World Report] Warnings over doctor shortages amid Italian health reforms - Marta Paterlini Lancet
  As the Italian Health Ministry plans changes to primary care, health workers associations warn of a shortage of staff. Marta Paterlini reports. (The Lancet 399, 10341 (2022))
• 00:00
  [Perspectives] Harold Gillies and the battleground of surgical innovation - Fay Bound Alberti Lancet
  The damaged faces of soldiers treated by Harold Gillies have become something of a staple of popular culture since the World War 1 centenary. Thus, “shocking pictures” of “horribly disfigured” servicemen have featured in British tabloids, their faces assembled into a jarring photo-mosaic, showing a (...) (The Lancet 399, 10341 (2022))
• 00:00
  [Perspectives] Health as activism: rethinking social medicine in India - Pratik Chakrabarti Lancet
  The COVID-19 pandemic has exposed deep problems and inequities in India's health infrastructure, which has suffered from decades of underinvestment. But the pandemic also galvanised a wide range of community participation. Non-governmental organisations (NGOs), volunteers, and health-care (...) (The Lancet 399, 10341 (2022))
• 00:00
  [Obituary] Donald Paul Pinkel - Geoff Watts Lancet
  Paediatric oncologist specialising in leukaemia. He was born on Sept 7, 1926 in Buffalo, NY, USA, and died on March 9, 2022 in San Luis Obispo, CA, USA, aged 95 years. (The Lancet 399, 10341 (2022))
• 00:00
  [Correspondence] Adjustable intragastric balloon for obesity - Vasileios Charalampakis, Yashasvi Rajeev, Rishi Singhal Lancet
  We agree with Barham K Abu Dayyeh and colleagues1 that “invasiveness, expense, long-term risks, and patients’ acceptance” reduce the popularity of bariatric surgery, which they demonstrate in the context of a well designed multicentre, randomised trial that supports the safety and efficacy of the (...) (The Lancet 399, 10341 (2022))
• 00:00
  [Correspondence] Adjustable intragastric balloon for obesity - Vitor Ottoboni Brunaldi, Manoel Galvao Neto Lancet
  We congratulate Barham K Abu Dayehh and colleagues and their collaborators for the completion of such laborious work. They show an adequate weight loss with adjustable intragastric balloon, and an acceptable safety profile.1 (The Lancet 399, 10341 (2022))
• 00:00
  [Correspondence] Adjustable intragastric balloon for obesity – Author's reply - Barham K Abu Dayyeh Lancet
  We appreciate the opportunity to address our colleagues’ queries in response to our study investigating the adjustable intragastric balloon for obesity.1 (The Lancet 399, 10341 (2022))
• 00:00
  [Correspondence] Pharmacotherapy for adults with overweight and obesity - Elizabeth Sturgiss, Lauren Ball, David Blane, Marita Hennessy, Fiona Quigley Lancet
  Although Qingyang Shi and colleagues’ systematic review and network meta-analysis of pharmacotherapy for overweight and obesity1 appears well conducted, we believe that the interpretation of the findings is not person-centred, and is perhaps even misleading, for several (...) (The Lancet 399, 10341 (2022))
• 00:00
  [Correspondence] Pharmacotherapy for adults with overweight and obesity – Authors' reply - Qingyang Shi, Yang Wang, Sheyu Li Lancet
  We agree with Elizabeth Sturgiss and colleagues that patient-centred care is crucial, which is why it is represented in the performance of the systematic review and meta-analysis.1 The patient-centred approach is never a one-size-fits-all without case-to-case consideration. Targeting adults (...) (The Lancet 399, 10341 (2022))
• 00:00
  [Correspondence] Head and neck cancer: high-end technology is no guarantee of high-quality care - Johannes H A M Kaanders Lancet
  After seven impressive wins of the Formula 1 World Championship, Lewis Hamilton was defeated in Abu Dhabi in December, 2021, by Max Verstappen, a young talented Dutch driver. In my opinion, Verstappen did not win because he had a faster car but because he was the better pilot and because he had (...) (The Lancet 399, 10341 (2022))
• 00:00
  [Correspondence] Head and neck cancer: high-end technology is no guarantee of high-quality care – Authors' reply - Nabil F Saba, Mayur D Mody, James W Rocco, Robert I Haddad, Sue S Yom Lancet
  We thank Johannes H A M Kaanders for commenting on our Seminar in which we discussed recent advances in the management of head and neck squamous cell carcinomas.1 We agree with the need to exert caution in the wide and uncontrolled implementation of novel modalities such as transoral robotic (...) (The Lancet 399, 10341 (2022))
• 00:00
  [Articles] Intrauterine device-related uterine perforation incidence and risk (APEX-IUD): a large multisite cohort study - Susan D Reed, Xiaolei Zhou, Laura Ichikawa, Jennifer L Gatz, Jeffrey F Peipert, Mary Anne Armstrong, Tina Raine-Bennett, Darios Getahun, Michael J Fassett, Debbie A Postlethwaite, Jiaxiao M Shi, Alex Asiimwe, Federica Pisa, Juliane Schoendorf, Catherine W Saltus, Mary S Anthony, APEX-IUD study team Lancet
  Although the risk for uterine perforation with IUD insertion 4 days to 6 weeks or less post partum is nearly seven times that of insertion non-post partum, perforation remains an incredibly rare event for all clinical time points. Despite a slight increased risk of perforation with (...) (The Lancet 399, 10341 (2022))
• 00:00
  [Clinical Picture] Sweet's syndrome and Crohn's disease diagnosed simultaneously - Juan Bañares, Laia Aceituno, Alba Jiménez, Avonello Maynard, Eduardo Dacosta Escobar, Carmen Alemán Lancet
  A 58-year-old man attended our hospital with a 3-month history of bloody diarrhoea, proctalgia, arthralgia, and weight loss. The patient said that when his symptoms began, he had noticed a rash that had recently become more conspicuous. Accompanying the change in the rash, he said he had (...) (The Lancet 399, 10341 (2022))

3 June

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Implications for racial inequities in maternal health if Roe v Wade is lost - Anna Kheyfets, Brenna Miller, Ndidiamaka Amutah-Onukagha Lancet
  Unsafe abortion contributes substantially to maternal deaths worldwide in countries where safe abortions are not accessible.1 Despite the harms of unsafe abortion, the US Supreme Court draft opinion on Dobbs v Jackson Women's Health Organization showed that the court aims to overturn Roe v Wade (...) (The Lancet 400, 10345 (2022))

2 June

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Department of Error] Department of Error Lancet
  Samarasekera U. Helena Hansen: developing structural humility in medicine. Lancet 2022; 399: 2007—In this Profile the first name in the title and first sentence has been corrected to Helena. This correction was made to the online version on June 1, (...) (The Lancet 399, 10342 (2022))

1 June

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Menopause care and over the counter vaginal oestradiol - Zoe Schaedel, Janice Rymer Lancet
  Menopause care is receiving more attention than ever before in the UK and has been highlighted as a priority area in the upcoming Women's Health Strategy for England and through the work of the UK Menopause Taskforce.1 These efforts bring an opportunity to increase access to menopause support, (...) (The Lancet 399, 10343 (2022))

31 May

Lancet https://www.thelancet.com/journals/lancet

• 00:30
  [Comment] Is the US infant formula shortage an avoidable crisis? - Tanya Doherty, Anna Coutsoudis, David McCoy, Lori Lake, Catherine Pereira-Kotze, Jeffrey Goldhagen, Max Kroon Lancet
  Since February, 2022, there has been an acute shortage of commercial milk formula in the USA. This shortage is the result of the recall of several products manufactured by Abbott Nutrition, the largest manufacturer of infant formula in the USA, due to bacterial contamination and shutdown of (...) (The Lancet 400, 10346 (2022))

28 May

Lancet https://www.thelancet.com/journals/lancet

• 00:00
  [Perspectives] Helena Hansen: developing structural humility in medicine - Udani Samarasekera Lancet
  Helena Hansen is Co-chair for the Research Theme in Health Equity and Translational Social Science and Associate Director of the Center for Social Medicine at the David Geffen School of Medicine, University of California, Los Angeles (UCLA), USA. She helped shaped this role before taking it up (...) (The Lancet 399, 10340 (2022))
• 00:00
  [World Report] Calls for independent evaluation of ACT-A welcomed - Ann Danaiya Usher Lancet
  Experts working with the Access to COVID-19 Tools Accelerator welcome the conclusions of a key report on pandemic preparedness. Ann Danaiya Usher reports. (The Lancet 399, 10340 (2022))
• 00:00
  [Perspectives] Impossible times - Chloe Wilson Lancet
  During the COVID-19 pandemic health-care workers have often found themselves in the media spotlight. The pandemic has been framed as a war, and health-care workers have been labelled as soldiers on the front line. But using a wartime narrative to depict the pandemic is dangerous “None of you (...) (The Lancet 399, 10340 (2022))
• 00:00
  [Perspectives] Why stories about illness matter - Deepika Bahri Lancet
  Plagues and contagious epidemics have long inspired writers, Sophocles, Boccaccio, Daniel Defoe, Mary Shelley, Albert Camus, and Orhan Pamuk among them. In the past decades, other diseases have found gifted chroniclers. Oncologist Siddhartha Mukherjee's bestselling The Emperor of All Maladies: (...) (The Lancet 399, 10340 (2022))