00:00Molecular profiling of kidney compartments from serial biopsies differentiate treatment responders from non-responders in lupus nephritis -
Samir V. Parikh, Ana Malvar, Huijuan Song, John Shapiro, Juan Manuel Mejia-Vilet, Isabelle Ayoub, Salem Almaani, Sethu Madhavan, Valeria Alberton, Celeste Besso, Bruno Lococo, Anjali Satoskar, Jianying Zhang, Lianbo Yu, Paolo Fadda, Michael Eadon, Dan Birmingham, Latha P. Ganesan, Wael Jarjour, Brad H. Rovin
Kidney Int
The immune pathways that define treatment response and non-response in lupus nephritis (LN) are unknown. To characterize these intra-kidney pathways, transcriptomic analysis was done on protocol kidney biopsies obtained at flare (initial biopsy (Bx1)) and after treatment (second biopsy (Bx2)) (...) (Kidney International (2022))
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In the above-stated article, the sentence “Next generation sequencing of the mitochondrial genome failed to detect any pathogenic variants.” was not included in the third paragraph of the article, after the description of Figure 1b. Here is the paragraph with the sentence (...) (Kidney International 102, 1 (2022))
00:00The authors reply -
Enric Vilar, Raja M. Kaja Kamal, James Fotheringham, Amanda Busby, Jocelyn Berdeprado, Ewa Kislowska, David Wellsted, Bassam Alchi, James O. Burton, Andrew Davenport, Ken Farrington
Kidney Int
We acknowledge the comments by Torreggiani et al.1 on our feasibility randomized controlled trial of incremental dialysis2 regarding the timing of initiating incremental dialysis. We randomized patients within 3 months of initiating hemodialysis rather than from day 1. The question is whether (...) (Kidney International 102, 1 (2022))
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Fabry disease results from a deficiency of the enzyme galactosidase-A (GLA), leading to accumulation of its substrates, primarily globotriaosylceramide (GL3) in various cells, including podocytes. As the disease is X-linked, males are severely affected, and all podocytes have the Fabry (...) (Kidney International 102, 1 (2022))
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McNulty and colleagues describe the glomerular transcriptional landscape of subjects with APOL1 (the gene encoding apolipoprotein L1)–associated kidney disease, using bulk RNA sequencing. They found the following: APOL1 gene expression was higher in individuals with APOL1 high-risk genetic (...) (Kidney International 102, 1 (2022))
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Hung et al. (JAMA Intern Med. 2022;182:386–395.) (Kidney International 102, 1 (2022))
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Assessing the prognosis is essential in chronic diseases, such as IgA nephropathy. The 2021 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend the “International IgAN Prediction Tool” (available at www.qxmd.com) for this. The key limitation was that the tool was only validated (...) (Kidney International 102, 1 (2022))
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Cardiovascular events are the leading cause of death in chronic kidney disease. A recent analysis from the High-Sensitivity Troponin in the Evaluation of Patients With Suspected Acute Coronary Syndrome trial focused on results in those with reduced estimated glomerular filtration rate. This (...) (Kidney International 102, 1 (2022))
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The editorial board of Kidney International would like to express our heartfelt condolences to the family of Dr. James Knochel, who passed away on April 13, 2022, at the age of 91. Dr. Knochel served as an Associate Editor of Kidney International from 1984–2005. Dr. Knochel had a long and (...) (Kidney International 102, 1 (2022))
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Regenerative repair following injury to proximal tubular epithelial cells (PTECs) is essential to restore the kidney to normal function in acute kidney injury. Failure to accomplish this leads to chronic kidney disease. Expression of the paired-box transcription factor Pax2 in PTECs is required (...) (Kidney International 102, 1 (2022))
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Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound (...) (Kidney International 102, 1 (2022))
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We read with interest the randomized controlled trial by Vilar et al., who compared standard thrice-weekly hemodialysis (sHD) with twice weekly dialysis (iHD) in patients initiating maintenance hemodialysis (MHD).1 (Kidney International 102, 1 (2022))
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A 62-year-old woman with a kidney transplant was admitted with a 3-week history of shortness of breath. On examination, she was noted to have a functioning upper limb arteriovenous fistula (AVF), enlargement of her left jugular vein (Figure 1a and b), decreased basal pulmonary breath sounds, (...) (Kidney International 102, 1 (2022))
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A 45-year-old White woman with recently diagnosed type 2 diabetes mellitus and hypertension presented with acute kidney injury and septic shock with gram-positive bacteremia from a toe wound. She was treated with vancomycin and piperacillin-tazobactam followed by ertapenem. She had no exposure (...) (Kidney International 102, 1 (2022))
00:00Crystal-induced colitis -
Andrea Spasiano, Federica Castri, Maria Cristina Giustiniani, Maria Elena Riccioni, Alessandro Naticchia, Giuseppe Grandaliano, Nicola Panocchia
Kidney Int
A 59-year-old man undergoing dialysis was admitted to our hospital with lower limb ischemia; he had a story of long-term use of phosphate and potassium chelator. Because of anemia and repeated episodes of bowel bleeding, he underwent colonoscopy with a biopsy of the ileocecal valve and (...) (Kidney International 102, 1 (2022))
00:00The Case | Inflammatory polyarthritis in a kidney transplant recipient -
Karthikeyan Manoharan, Priyansh Gupta, Hitaishi Mehta, Ritambhra Nada, Aravind Sekar, Ashwani Kumar, Aman Sharma, Manish Rathi, Harbir Singh Kohli, Keshavamurthy Vinay, Raja Ramachandran
Kidney Int
A 52-year-old man underwent live donor kidney transplantation for end-stage kidney disease in 2001 (20 years post-transplant). His maintenance immunosuppressive therapy was tacrolimus, azathioprine, and prednisolone. He had chronic allograft dysfunction (serum creatinine level of 3 mg/dl). (...) (Kidney International 102, 1 (2022))
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Defining changes in gene expression during health and disease is critical for the understanding of human physiology. In recent years, single-cell/nuclei RNA sequencing (sc/snRNAseq) has revolutionized the definition and discovery of cell types and states as well as the interpretation of organ- (...) (Kidney International (2022))
00:00Indigenous Peoples’ perspectives of living with chronic kidney disease: systematic review of qualitative studies -
Marianne Kerr, Nicole Evangelidis, Penelope Abbott, Jonathan C. Craig, Michelle Dickson, Nicole Scholes-Robertson, Victoria Sinka, Rahim T. Vastani, Katherine Widders, Jacqueline Stephens, Allison Tong
Kidney Int
Indigenous Peoples are defined as those who first lived in a region and have distinct cultural traditions, knowledge, and language that provide a basis for positive self-image and healthy identity.1 Indigenous Peoples have retained much of their cultural identity and displayed remarkable (...) (Kidney International (2022))