19 January

Kidney Int http://www.kidney-international.org/

• 10:16
  Table of Contents Kidney Int
  (Kidney International 103, 2 (2023))
• 10:16
  Subscription Information Kidney Int
  (Kidney International 103, 2 (2023))
• 10:16
  Editorial Board Kidney Int
  (Kidney International 103, 2 (2023))
• 10:16
  Journal Club Kidney Int
  Xu et al. (Ann Rheum Dis. 2022;81:1712–1721.) (Kidney International 103, 2 (2023))
• 10:16
  in this issue Kidney Int
  Aspirin (ASA) has been postulated to improve cardiovascular outcomes in at-risk individuals, although the extent of protection remains controversial. The effect of ASA on cardiovascular outcomes in patients with chronic kidney disease (CKD) was examined in The International Polycap Study-3 (...) (Kidney International 103, 2 (2023))
• 10:16
  In memoriam: Rashad Sami Barsoum - Saraladevi Naicker, Mohamed Hany Hafez, John H. Dirks Kidney Int
  Rashad Sami Barsoum, a pioneer in nephrology in Egypt and Africa, and former secretary general (SG) of the International Society of Nephrology (ISN) and inaugural past president of the African Association of Nephrology (AFRAN), died on October 25, 2022, at the age of 81 years, after a long (...) (Kidney International 103, 2 (2023))
• 10:16
  Uromodulin and CKD: insight into variant pathogenicity - Nora Franceschini, Jonathan S. Berg Kidney Int
  We are entering a brave new world of increasingly detailed understanding of the genetic architecture and cellular mechanisms of disease—one that blurs traditional lines between monogenic and multifactorial etiology and raises challenging new questions about how to incorporate genetic variants of (...) (Kidney International 103, 2 (2023))
• 10:16
  Corrigendum to “Novel retinal vascular phenotypes for the potential assessment of long-term risk in living kidney donors.” Kidney Int. 2022;102:661–665 - Ylenia Giarratano, Dan Pugh, Tariq E. Farrah, Gabriel C. Oniscu, Thomas J. MacGillivray, Baljean Dhillon, Neeraj Dhaun, Miguel O. Bernabeu Kidney Int
  DOI of original article: https://doi.org/10.1016/j.kint.2022.06.019 (Kidney International 103, 2 (2023))
• 10:16
  The authors reply - Sander Groen in ’t Woud, Loes F.M. van der Zanden, Michiel F. Schreuder Kidney Int
  In the last decades, several studies showed that congenital solitary functioning kidney (CSFK) predisposes to kidney injury, which was confirmed in our recent article in Kidney International.1 As Marzuillo et al. point out in their letter, the percentage of kidney injury found varies greatly (...) (Kidney International 103, 2 (2023))
• 10:16
  Kidney injury and congenital solitary functioning kidney: more research efforts are needed - Pierluigi Marzuillo, Anna Di Sessa, Stefano Guarino, Cesare Polito Kidney Int
  We appreciated the study by Groen in 't Woud et al., investigating for risk factors of kidney injury (KI) in a large cohort of solitary functioning kidney.1 In this article, the prevalence of any KI was of 75% at 18 years of age in patients with congenital solitary functioning kidney (CSFK). It (...) (Kidney International 103, 2 (2023))
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  Corrigendum to “Ttc21b deficiency attenuates autosomal dominant polycystic kidney disease in a kidney tubular- and maturation-dependent manner.” Kidney Int. 2022;102:577–591 - Wei Wang, Luciane M. Silva, Henry H. Wang, Matthew A. Kavanaugh, Tana S. Pottorf, Bailey A. Allard, Damon T. Jacobs, Rouchen Dong, Joseph T. Cornelius, Aakriti Chaturvedi, Katherine I. Swenson-Fields, Timothy A. Fields, Michele T. Pritchard, Madhulika Sharma, Chad Slawson, Darren P. Wallace, James P. Calvet, Pamela V. Tran Kidney Int
  DOI of original article: https://doi.org/10.1016/j.kint.2022.04.034 (Kidney International 103, 2 (2023))
• 10:16
  Taking the A(llorecognition) train: connecting passenger T cells to DSA - Griffith B. Perkins, Shane T. Grey, P. Toby Coates Kidney Int
  In 1976, Lafferty et al.1 demonstrated that “passenger leukocytes” within the transplanted allograft are key mediators of acute rejection. Although this finding provoked intense interest in antigen-presenting cells (APCs), both as the mediators of direct allorecognition and for their role in the (...) (Kidney International 103, 2 (2023))
• 10:16
  The authors reply - Tiffany N. Caza, Prema KS Jansi, Patrick D. Walker, Anila Abraham Kurien Kidney Int
  We found the case reported in the letter by Kaur et al.1 quite interesting. The authors present a patient with phospholipase A2 receptor (PLA2R)–positive membranous nephropathy (MN) in temporal association with complementary medicine containing strontium (Sr2+).1 Several heavy metals have been (...) (Kidney International 103, 2 (2023))
• 10:16
  Complementary medicine and phospholipase A2 receptor (PLA2R)–related membranous nephropathy—fortuitous or causal? - Prabhjot Kaur, Arun Prabhahar, Ashwani Kumar, Deeksha Pal, Vinod Kumar, Aravind Sekar, Vivekanand Jha, Ritambhra Nada, Jasmine Sethi, Smita Divyaveer, Manish Rathi, Harbir Singh Kohli, Raja Ramachandran Kidney Int
  We read with interest the article by Kurien et al. highlighting enhanced neural epidermal growth factor-like 1 (NELL-1) expression with complementary and alternative medicine (CAM)–associated membranous nephropathy (MN).1 An association between intake of heavy metals and development of MN has (...) (Kidney International 103, 2 (2023))
• 10:16
  False-positive anti-PLA2R ELISA testing in patients with diabetes mellitus - Tiffany N. Caza, Christopher P. Larsen Kidney Int
  We found the study by Hoxha et al., “False Positivity for PLA2R1 Antibody Measured by ELISA in a Nephrotic Patient With No Membranous Nephropathy,” to be of interest.1 We identified 2 similar patients with biopsy-proven diabetic nephropathy with false-positive phospholipase A2 receptor (PLA2R) (...) (Kidney International 103, 2 (2023))
• 10:16
  Does kidney transplant improve health-related quality of life for youth with chronic kidney disease? - Rebecca J. Johnson, Bradley A. Warady Kidney Int
  Youth with chronic kidney disease are known to have impaired health-related quality of life (HRQOL), particularly as the disorder increases in severity. Few prospective, longitudinal investigations of HRQOL within the context of pediatric chronic kidney disease exist. In the current issue, Guha (...) (Kidney International 103, 2 (2023))
• 10:16
  Toward a bona fide animal model of PLA2R1-associated membranous nephropathy: one step forward - Franck Bihl, Gérard Lambeau Kidney Int
  The major form of membranous nephropathy is characterized by autoantibodies to phospholipase A2 receptor 1 (PLA2R1). The study by Tomas et al. describes the first animal model where human PLA2R1 is ectopically expressed in mouse podocytes. Intriguingly, the transgenic mice spontaneously develop (...) (Kidney International 103, 2 (2023))
• 10:16
  A disease-modifying approach to the treatment of IgA nephropathy targeting mucosal IgA synthesis and beyond - Rosanna Coppo Kidney Int
  The benefits and risks of systemic corticosteroids in the treatment of IgA nephropathy are still controversial. Part A results of the Efficacy and Safety of Nefecon in Patients With Primary IgA Nephropathy (NefIgArd) trial provide significant effects on decrease in proteinuria and protection (...) (Kidney International 103, 2 (2023))
• 10:16
  TIPS to decide whether to prescribe aspirin for the primary prevention of cardiovascular events in chronic kidney disease - Pavel S. Roshanov, Amit X. Garg Kidney Int
  Aspirin effectively prevents subsequent cardiovascular events. A post hoc subgroup analysis of the International Polycap Study 3 (TIPS-3) trial suggests that patients with chronic kidney disease might also benefit from aspirin for primary prevention. We consider the merits of doing so in (...) (Kidney International 103, 2 (2023))
• 10:16
  Erdheim-Chester disease: hairy kidney and coated aorta - Alexander Ritter, Julia Meier, Florian Angst, Wiebke Rösler, Harald Seeger Kidney Int
  A 71-year-old man presented with unintentional weight loss and abdominal and back pain. Blood work revealed elevated serum creatinine (194 ?mol/l; estimated glomerular filtration rate, 29 ml/min per 1.73 m2; Chronic Kidney Disease Epidemiology Collaboration formula), increased C-reactive (...) (Kidney International 103, 2 (2023))
• 10:16
  Good and evil, more reasons to study UPR - Reiko Inagi, Sho Hasegawa Kidney Int
  The unfolded protein response (UPR) pathway, launched by endoplasmic reticulum, maintains endoplasmic reticulum homeostasis. Dysregulated UPR pathway links disease phenotypes, such as proteinuria, inflammation, and fibrosis, in kidney disease. Although accumulating evidence indicates the (...) (Kidney International 103, 2 (2023))
• 10:16
  The Case | A benign reason behind a malignant finding - Joyita Bharati, Vanesa Bijol, Steven Salvatore, Kenar D. Jhaveri, Purva Sharma Kidney Int
  A 21-year-old man presented to the office for deranged kidney function. He was diagnosed to have C3 glomerulonephritis at the age of 18 years when he presented to his first physician with hypertension. Laboratory parameters showed high serum creatinine (2.7 mg/dl), low serum albumin (2.9 g/dl), (...) (Kidney International 103, 2 (2023))

16 January

Kidney Int http://www.kidney-international.org/

• 00:00
  Downregulation of G protein–coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury - Donghai Yang, Ming Tang, Mingming Zhang, Hongmei Ren, Xiaoping Li, Ziyue Zhang, Bo He, Song Peng, Wei Wang, Dandong Fang, Yi Song, Yao Xiong, Zhi Zhao Liu, Lijia Liang, Weibin Shi, Chunjiang Fu, Yijie Hu, Pedro A. Jose, Lin Zhou, Yu Han, Chunyu Zeng Kidney Int
  Ischemia/reperfusion injury of the kidney is associated with high morbidity and mortality, and treatment of this injury remains a challenge. G protein-coupled receptor kinase 4 (GRK4) plays a vital role in essential hypertension and myocardial infarction, but its function in kidney (...) (Kidney International (2023))

13 January

Kidney Int http://www.kidney-international.org/

• 00:00
  New advances in endocrine hypertension: from genes to biomarkers - Fabio L. Fernandes-Rosa, Sheerazed Boulkroun, Bakhta Fedlaoui, Marguerite Hureaux, Simon Travers-Allard, Tom Drossart, Judith Favier, Maria-Christina Zennaro Kidney Int
  Hypertension (HT) is a major cardiovascular risk factor that affects 10% to 40% of the general population in an age-dependent manner. Detection of secondary forms of HT is particularly important because it allows the targeted management of the underlying disease. Among hypertensive patients, (...) (Kidney International (2023))
• 00:00
  Osteopontin mediation of disturbed flow-induced endothelial mesenchymal transition through CD44 is a novel mechanism of neointimal hyperplasia in arteriovenous fistulae for hemodialysis access. - Chi-Jen Chang, Ying-Ju Lai, Ying-Chang Tung, Lung-Sheng Wu, Lung-An Hsu, Chi-Nan Tseng, Gwo-Jyh Chang, Kai-Chien Yang, Yung-Hsin Yeh Kidney Int
  In dysfunctional arteriovenous fistulae (AVF) for hemodialysis access, neointimal hyperplasia (NH) is prone to occur in the region exposed to disturbed flow. We hypothesized that disturbed flow contributes to NH in AVF by inducing endothelial mesenchymal transition (EndMT) through activation of (...) (Kidney International (2023))

11 January

Kidney Int http://www.kidney-international.org/

• 00:00
  Our shared responsibility: the urgent necessity of global environmentally sustainable kidney care - Caroline E. Stigant, Katherine A. Barraclough, Mark Harber, Nigel S. Kanagasundaram, Charu Malik, Vivekanand Jha, Raymond C. Vanholder Kidney Int
  The recently published Sixth Assessment Report of the Intergovernmental Panel on Climate Change informs that the climate emergency is human caused, is rapidly progressing, will worsen until at least midcentury regardless of future emissions scenarios, and heralds massive, unprecedented, and (...) (Kidney International (2023))

10 January

Kidney Int http://www.kidney-international.org/

• 00:00
  Discovery of seven novel putative antigens in membranous nephropathy and membranous lupus nephritis identified by mass spectrometry - Tiffany N. Caza, Aaron J. Storey, Samar I. Hassen, Christian Herzog, Rick D. Edmondson, John M. Arthur, Daniel J. Kenan, Christopher P. Larsen Kidney Int
  Multiple autoantigens have been identified in membranous nephropathy (MN) by tissue-based proteomics. However, antigenic targets of disease are unknown for over 10% of patients with MN and over half of those with membranous lupus nephritis (MLN). Here, we identified multiple new targets in (...) (Kidney International (2023))

4 January

Kidney Int http://www.kidney-international.org/

• 00:00
  Endemic rise in cases of acute kidney injury in children in Indonesia and Gambia: what is the likely culprit and why? - Tungki Pratama Umar, Nityanand Jain, Henri Azis Kidney Int
  A sudden rise in the cases of acute kidney injury (AKI) has been reported in Indonesia and Gambia that has been linked to the consumption of tainted syrup medications for cough, colds, pain, and fever. Preliminary investigations revealed multiple lapses in quality control during manufacturing (...) (Kidney International (2023))

1 January

Kidney Int http://www.kidney-international.org/

• 00:00
  Table of Contents Kidney Int
  (Kidney International 103, 1 (2023))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 103, 1 (2023))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 103, 1 (2023))
• 00:00
  Journal Club Kidney Int
  Herrington et al. (N Engl J Med. Published online November 4, 2022. https://www.nejm.org/doi/full/10.1056/NEJMoa2204233) (Kidney International 103, 1 (2023))
• 00:00
  Inadvertent stem cell transfer demonstrating a way for tolerance induction - Nina Pilat Kidney Int
  In this issue, Sobrino et al. present a case of hematopoietic chimerism and subsequent tolerance after isolated kidney transplantation in a pediatric patient with syndromic combined immune deficiency. This report not only highlights the chimerism approach for tolerance induction in (...) (Kidney International 103, 1 (2023))
• 00:00
  in this issue Kidney Int
  Transplantation of large organs, such as the intestine or liver, can result in hematopoietic chimerism, presumably because sufficient donor hematopoietic stem cells reside within the transplanted tissue. This was not thought to be possible with transplantation of a single kidney. Sobrino et al. (...) (Kidney International 103, 1 (2023))
• 00:00
  PD-1 inhibition in aged podocytes and glomerular disease - Marina De Cos, Kirk N. Campbell Kidney Int
  Kidney function is influenced by the complex process of aging, and the global increase in prevalence of chronic kidney disease is partially driven by increases in life expectancy and associated comorbidities. Histologically, kidney aging is characterized by a pattern of nephrosclerosis, with (...) (Kidney International 103, 1 (2023))
• 00:00
  Sans titre - Esmee C.M. Kooijmans, Helena J.H. van der Pal, Margreet A. Veening, Arend Bökenkamp, the Dutch LATER study group Kidney Int
  We thank Professor Schreuder1 for his interest in our study.2 He wondered if the decrease in estimated glomerular filtration rate (eGFR) in particular in the oldest childhood cancer survivors (CCSs) might be the result of nephrectomy, which was performed more often in this cohort. As suggested, (...) (Kidney International 103, 1 (2023))
• 00:00
  Long-term glomerular dysfunction after childhood cancer nephrectomy: what is the impact of nephrectomy and obesity? - Michiel F. Schreuder Kidney Int
  I read with much interest the article from Kooijmans et al. describing long-term glomerular dysfunction in childhood cancer survivors.1 As rightfully stated by the authors, a reduction in nephron mass will result in glomerular hyperfiltration, with glomerular injury over time.2 As the oldest (...) (Kidney International 103, 1 (2023))
• 00:00
  Transcriptional programming of pathogenic genes in polycystic kidney disease - Je Yeong Ko, Jong Hoon Park Kidney Int
  Transcriptional dysregulation is a prominent contributor to the pathogenesis of autosomal dominant polycystic kidney disease. Lakhia et al. identified an enhancer landscape associated with disease genes and its pathologic role in autosomal dominant polycystic kidney disease to understand cyst (...) (Kidney International 103, 1 (2023))
• 00:00
  Value of measuring central blood pressure in clinical practice - James E. Sharman Kidney Int
  This article is an invited piece to provide a “pro” point of view on the clinical value of measuring central blood pressure (BP) over and above-standard cuff BP. Evidence to support the clinical value of cuff BP is among the strongest in medicine. However, a common misconception is that because (...) (Kidney International 103, 1 (2023))
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  How should blood pressure be measured? Con: the peripheral blood pressure is sufficient - Markus van der Giet Kidney Int
  It has been shown in the past decades that the central blood pressure (cBP) values measured in the aorta differ significantly from the peripheral measured blood pressure (pBP) values. In the aorta, the systolic blood pressure is cushioned by the high elasticity, and the increased stiffness (...) (Kidney International 103, 1 (2023))
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  Central blood pressure: nice to know but not yet ready for routine practice - Jürgen Floege Kidney Int
  A few years ago, my division bought new 24-hour blood pressure (BP) measurement devices. One sales argument of the manufacturer was that the new devices can also record central blood pressure, and we thought this is a great added feature. Central blood pressure is regarded as an index of aortic (...) (Kidney International 103, 1 (2023))
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  Estimating glomerular filtration rate from serum creatinine concentration in children with augmented renal clearance: all formulas are equivocal, but some are more equivocal than others - Pascal André, Haithem Chtioui, Kim Dao, Laura E. Rothuizen, Ermindo R. Di Paolo, Manuel Diezi, Pierre-Alex Crisinel, François Cachat, Hassib Chehade, Thierry Buclin Kidney Int
  Creatinine-based formulas for estimated glomerular filtration rate (eGFR) are widely used to monitor kidney function, to grade chronic kidney disease, and to adjust drug dosages. Specific formulas have been developed for children. The quadratic formula described in this journal, which combines (...) (Kidney International 103, 1 (2023))
• 00:00
  Challenges and opportunities in interventions for chronic kidney disease of unknown origin (CKDu): report from the International Society of Nephrology Consortium of Collaborators on CKDu - Brendan Smyth, Jason Glaser, Jaime Butler-Dawson, Nishantha Nanayakkara, David H. Wegman, Shuchi Anand, Adeera Levin, International Society of Nephrology’s International Consortium of Collaborators on Chronic Kidney Disease of Unknown Etiology (i3C) Kidney Int
  Chronic kidney disease of unknown origin (CKDu) is a progressive tubulointerstitial nephropathy reported principally in agricultural communities, specifically manual laborers in dry, lowland regions of Central America, Sri Lanka, and Southern India.1,2 Further research may reveal whether it is (...) (Kidney International 103, 1 (2023))
• 00:00
  Corrigendum to “Myeloid cyclooxygenase-2/prostaglandin E2/E-type prostanoid receptor 4 promotes transcription factor MafB-dependent inflammatory resolution in acute kidney injury.” Kidney Int. 2022;101:79–91 - Yu Pan, Shirong Cao, Andrew S. Terker, Jiaqi Tang, Kensuke Sasaki, Yinqiu Wang, Aolei Niu, Wentian Luo, Dhouha Daasi, Xiaofeng Fan, Suwan Wang, Matthew H. Wilson, Ming-Zhi Zhang, Raymond C. Harris Kidney Int
  The authors of the above-stated article regret the omission of the author Dhouha Daasi, Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA, and Vanderbilt Center for Kidney Disease, Vanderbilt University School of (...) (Kidney International 103, 1 (2023))
• 00:00
  Fluid volume management in hemodialysis: never give up! - Manfred Hecking, Magdalena Madero, Friedrich K. Port, Daniel Schneditz, Peter Wabel, Charles Chazot Kidney Int
  Every hemodialysis session starts with the question of how much fluid should be removed, which can currently not be answered precisely. Herein, we first revisit the “probing-dry-weight” concept, using the historical example of Tassin/France (practicing also “long, slow dialysis”): Mortality (...) (Kidney International 103, 1 (2023))
• 00:00
  Youth with single kidneys—what is the evidence of risk? - Julie R. Ingelfinger Kidney Int
  Children and youth with a congenital or acquired single functioning kidney are at risk for development of kidney injury and chronic kidney disease. How best to use surrogate measures associated with risk factors poses many problems. The risk of progressive kidney disease for those with a single (...) (Kidney International 103, 1 (2023))
• 00:00
  Hypokalemia due to ectopic adrenocorticotropic hormone secondary to metastatic lung carcinoma - Nikita Pawar, Vaibhav Tiwari, Anurag Gupta, Vinant Bhargava, Shiv Chadha, Salil Bhargava, Manish Malik, Ashwani Gupta, Anil Kumar Bhalla, D.S. Rana Kidney Int
  A 58-year-old man with diabetes mellitus and a history of chronic smoking presented with a 3-month history of lower back pain followed by lower limb weakness, uncontrolled blood glucose, and hypertension for the last 1 month. On physical examination, he had palpable right supraclavicular lymph (...) (Kidney International 103, 1 (2023))
• 00:00
  A beautiful, complex simplicity: the origins of nephron segmentation uncovered by single-cell sequencing of the pronephros - Peter D. Vize Kidney Int
  Pronephric kidneys have a single large nephron that provides essential osmoregulation in amphibians and fish until the adult kidney forms. As mammalian kidneys evolved from the simple pronephric kidneys of the early vertebrates, understanding the structure and function of pronephroi gives (...) (Kidney International 103, 1 (2023))
• 00:00
  Finerenone in chronic kidney disease and type 2 diabetes: the known and the unknown - Edouard L. Fu, Alexander Kutz, Rishi J. Desai Kidney Int
  The novel nonsteroidal mineralocorticoid receptor antagonist finerenone has been shown to reduce the risk of kidney and cardiovascular outcomes in patients with type 2 diabetes and chronic kidney disease. In this issue of Kidney International, Bakris et al. present new data on the kidney (...) (Kidney International 103, 1 (2023))
• 00:00
  Kidney involvement in Rosai-Dorfman disease - Martina Mazzariol, Francesco Peyronel, Filippo Fagni, Andrea Minervini, Raffaella Santi, Simone Agostini, Augusto Vaglio Kidney Int
  A 32-year-old woman was referred to us for bilateral hydroureteronephrosis due to suspected idiopathic retroperitoneal fibrosis, for which she had received several immunosuppressive therapies (i.e., glucocorticoids, rituximab, and tocilizumab) without benefit. No previous imaging scans were (...) (Kidney International 103, 1 (2023))
• 00:00
  The Case | Hyperammonemia in a non-cirrhotic hemodialysis patient - Tomoki Taniguchi, Mayumi Tomita, Noriyuki Iehara Kidney Int
  A 78-year-old woman presented with recurrent encephalopathy after hemodialysis initiation. Her medical history included end-stage renal disease, congestive heart failure, and cerebral infarction. Her medication included aspirin, losartan, carvedilol, pravastatin, and lansoprazole. Maintenance (...) (Kidney International 103, 1 (2023))

29 December

Kidney Int http://www.kidney-international.org/

• 00:00
  The transcription factor ATF4 mediates endoplasmic reticulum stress-related podocyte injury and slit diaphragm defects - Vanessa Krausel, Lisanne Pund, Harald Nüsse, Hussein Bachir, Andrea Ricker, Jürgen Klingauf, Thomas Weide, Hermann Pavenstädt, Michael P. Krahn, Daniela A. Braun Kidney Int
  Mutations in OSGEP and four other genes that encode subunits of the KEOPS complex cause Galloway-Mowat syndrome, a severe, inherited kidney-neurological disease. The complex catalyzes an essential posttranscriptional modification of tRNA and its loss of function induces endoplasmic reticulum (...) (Kidney International (2022))

26 December

Kidney Int http://www.kidney-international.org/

• 00:00
  Pathological characteristics of light chain crystalline podocytopathy - Samih H. Nasr, Satoru Kudose, Vincent Javaugue, Stéphanie Harel, Samar M. Said, Virginie Pascal, M. Barry Stokes, Julie A. Vrana, Surendra Dasari, Jason D. Theis, George A. Osuchukwu, Insara Jaffer Sathick, Arjun Das, Ali Kashkouli, Elliot J. Suchin, Yaakov Liss, Zalman Suldan, Jerome Verine, Bertrand Arnulf, Alexis Talbot, Sanjeev Sethi, Mohamad Zaidan, Jean-Michel Goujon, Anthony M. Valeri, Ellen D. Mcphail, Christophe Sirac, Nelson Leung, Frank Bridoux, Vivette D. (...) Kidney Int
  Monoclonal immunoglobulin light chain (LC) crystalline inclusions within podocytes are rare, poorly characterized entities. To provide more insight, we now present the first clinicopathologic series of LC crystalline podocytopathy (LCCP) encompassing 25 patients (68% male, median age 56 years). (...) (Kidney International (2022))
• 00:00
  Ubiquitin-specific protease 11 promotes partial epithelial-to-mesenchymal transition by deubiquitinating the epidermal growth factor receptor during kidney fibrosis - Yingfeng Shi, Min Tao, Hui Chen, Xiaoyan Ma, Yi Wang, Yan Hu, Xun Zhou, Jinqing Li, Binbin Cui, Andong Qiu, Shougang Zhuang, Na Liu Kidney Int
  The aberrant expression of ubiquitin-specific protease 11 (USP11) is believed to be related to tumor progression. However, few studies have reported the biological function and clinical importance of USP11 in kidney fibrosis. Here, we demonstrated USP11 was highly upregulated in the kidneys (...) (Kidney International (2022))

23 December

Kidney Int http://www.kidney-international.org/

• 00:00
  Individuals heterozygous for ALG8 protein-truncating variants are at increased risk of a mild cystic kidney disease - Benjamin Apple, Gino Sartori, Bryn Moore, Kiran Chintam, Gurmukteshwar Singh, Prince Mohan Anand, Natasha T. Strande, Tooraj Mirshahi, William Triffo, Alexander R. Chang Kidney Int
  ALG8 protein-truncating variants (PTVs) have previously been described in patients with polycystic liver disease and in some cases cystic kidney disease. Given a lack of well-controlled studies, we determined whether individuals heterozygous for ALG8 PTVs are at increased risk of cystic kidney (...) (Kidney International (2022))
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  Machine learning does not outperform traditional statistical modelling for kidney allograft failure prediction - Agathe Truchot, Marc Raynaud, Nassim Kamar, Maarten Naesens, Christophe Legendre, Michel Delahousse, Olivier Thaunat, Matthias Buchler, Marta Crespo, Kamilla Linhares, Babak J. Orandi, Enver Akalin, Gervacio Soler Pujol, Helio Tedesco Silva, Gaurav Gupta, Dorry L. Segev, Xavier Jouven, Andrew J. Bentall, Mark D. Stegall, Carmen Lefaucheur, Olivier Aubert, Alexandre Loupy Kidney Int
  Machine learning (ML) models have recently shown potential for predicting kidney allograft outcomes. However, their ability to outperform traditional approaches remains poorly investigated. Therefore, using large cohorts of kidney transplant recipients from 14 centers worldwide, we developed (...) (Kidney International (2022))

21 December

Kidney Int http://www.kidney-international.org/

• 00:00
  Tubular-specific expression of HIV protein Vpr leads to severe tubulointerstitial damage accompanied by progressive fibrosis and cystic development - Yuqiang Chen, Ya Chen, Jia Fu, Zeguo Sun, Huilin Li, Wenzhen Xiao, Jing E, Benjamin Y. Lo, Niansong Wang, Weijia Zhang, Mary E. Klotman, Paul E. Klotman, Jeffrey B. Kopp, Vivette D. D’Agati, John Cijiang He, Kyung Lee Kidney Int
  Chronic kidney disease (CKD) is a common cause of morbidity in human immunodeficiency virus (HIV)-positive individuals. HIV infection leads to a wide spectrum of kidney cell damage, including tubular epithelial cell (TEC) injury. Among the HIV-1 proteins, the pathologic effects of viral protein (...) (Kidney International (2022))
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  The transcription factor Fosl1 preserves Klotho expression and protects from acute kidney injury - Leticia Cuarental, Marta Ribagorda, Maria I. Ceballos, Aranzazu Pintor-Chocano, Sol M. Carriazo, Ana Dopazo, Enrique Vazquez, Beatriz Suarez-Alvarez, Pablo Cannata-Ortiz, Ana B. Sanz, Alberto Ortiz, Maria D. Sanchez-Niño Kidney Int
  Increased expression of AP-1 transcription factor components has been reported in acute kidney injury (AKI). However, the role of specific components, such as Fosl1, in tubular cells or AKI is unknown. Upstream regulator analysis of murine nephrotoxic AKI transcriptomics identified AP-1 as (...) (Kidney International (2022))

19 December

Kidney Int http://www.kidney-international.org/

• 00:00
  Untargeted metabolomics of perfusate and their association with hypothermic machine perfusion and allograft failure - Richard X. Liu, Neel Koyawala, Heather R. Thiessen-Philbrook, Mona D. Doshi, Peter P. Reese, Isaac E. Hall, Sumit Mohan, Chirag R. Parikh Kidney Int
  Although hypothermic machine perfusion (HMP) is associated with improved kidney graft viability and function, the underlying biological mechanisms are unknown. Untargeted metabolomic profiling may identify potential metabolites and pathways that can help assess allograft viability and (...) (Kidney International (2022))
• 00:00
  Mapping the T cell epitopes of the M-type transmembrane phospholipase A2 receptor in primary membranous nephropathy - Xiao-dan Zhang, Cai-xia Lin, Zhao Cui, Qiu-hua Gu, Bing-jia Yan, Lei Liu, Wen-chao Song, Yi Shi, Hanna Debiec, Pierre Ronco, Ming-hui Zhao Kidney Int
  The M-type phospholipase A2 receptor (PLA2R) is the major autoantigen of primary membranous nephropathy (MN). Despite many studies on B-cell epitopes recognized by antibodies, little is known about T-cell epitopes. Herein, we synthesized 123 linear peptides, each consisting of 15-22 amino acids (...) (Kidney International (2022))

18 December

Kidney Int http://www.kidney-international.org/

• 00:00
  Soluble urokinase plasminogen activator receptor (suPAR) promotes atherosclerosis - Tilman B. Drueke, Ziad A. Massy Kidney Int
  Patients with chronic kidney disease (CKD) frequently experience cardiovascular disease (CVD). The rate of CVD events rises steadily with the progression of CKD and is markedly increased compared with people without CKD.1 The underlying arterial disease consists of at least 2 types (namely, (...) (Kidney International (2022))

11 December

Kidney Int http://www.kidney-international.org/

• 00:00
  Cord blood effectively resists mineralization through mechanisms that stabilize calciprotein particles - Edward R. Smith, Paul J. Champion de Crespigny, Fatima Vally, Tim D. Hewitson, Nigel D. Toussaint, Thomas J. Cade, Stephen G. Holt Kidney Int
  Calcium and phosphate levels in serum are maintained well below the point of spontaneous precipitation yet well above the solubility of bulk bone mineral, readily sustaining crystal growth and ripening once seeded. Despite this metastability, unwanted mineral deposition outside osseous tissue (...) (Kidney International (2022))

8 December

Kidney Int http://www.kidney-international.org/

• 00:00
  Renal AA amyloidosis: presentation, diagnosis, and current therapeutic options: a review - Sabine Karam, Mohamad Haidous, Virginie Royal, Nelson Leung Kidney Int
  Amyloid A amyloidosis is thought to be the second most common form of systemic amyloidosis behind amyloidosis secondary to monoclonal Ig. It is the result of deposition of insoluble fibrils in the extracellular space of tissues and organs derived from the precursor protein serum amyloid A, an (...) (Kidney International (2022))

5 December

Kidney Int http://www.kidney-international.org/

• 00:00
  A polygenic score for reduced kidney function and adverse outcomes in a cohort with chronic kidney disease - Inga Steinbrenner, Zhi Yu, Jin Jin, Ulla T. Schultheiss, Fruzsina Kotsis, Morgan E. Grams, Josef Coresh, Matthias Wuttke, GCKD Investigators, Florian Kronenberg, Kai-Uwe Eckardt, Nilanjan Chatterjee, Peggy Sekula, Anna Köttgen Kidney Int
  Chronic kidney disease (CKD) is a global health burden of increasing importance that affects >10% of the general adult population.1 CKD is defined as the sustained presence of abnormalities of kidney structure or function, and it is classified using estimated glomerular filtration rate (...) (Kidney International 103, 2 (2023))
• 00:00
  Glomerular diseases in pregnancy: pragmatic recommendations for clinical management - Fadi Fakhouri, Nora Schwotzer, Gianfranca Cabiddu, Jonathan Barratt, Hélène Legardeur, Vesna Garovic, Alejandra Orozco-Guillen, Jack Wetzels, Eric Daugas, Gabriella Moroni, Marina Noris, Vincent Audard, Manuel Praga, Elisa Llurba, Grégoire Wuerzner, Rossella Attini, David Desseauve, Elena Zakharova, Claudio Luders, Kate Wiles, Filomena Leone, Shilpanjali Jesudason, Nathalie Costedoat-Chalumeau, Andrea Kattah, Virgilia Soto-Abraham, Alexandre Karras, Jai Prakash, Liz Lightstone, Pierre Ronco, Claudio Ponticelli, Gerald Appel, Giuseppe Remuzzi, Vassilis Tsatsaris, Giorgina Barbara (...) Kidney Int
  Our understanding of the various aspects of pregnancy in women with kidney diseases has significantly improved in the last decades. Nevertheless, little is known about specific kidney diseases. Glomerular diseases are not only a frequent cause of chronic kidney disease in young women, but (...) (Kidney International 103, 2 (2023))

2 December

Kidney Int http://www.kidney-international.org/

• 00:00
  Targeting inflammation to treat diabetic kidney disease: the road to 2030 - Sandra Rayego-Mateos, Raul R Rodrigues-Diez, Beatriz Fernandez-Fernandez, Carmen Mora-Fernández, Vanessa Marchant, Javier Donate-Correa, Juan F. Navarro-González, Alberto Ortiz, Marta Ruiz-Ortega Kidney Int
  Diabetic kidney disease (DKD) is one of the fastest growing causes of chronic kidney disease and associated morbidity and mortality. Preclinical research has demonstrated the involvement of inflammation in its pathogenesis and in the progression of kidney damage, supporting clinical trials (...) (Kidney International 103, 2 (2023))

1 December

Kidney Int http://www.kidney-international.org/

• 00:00
  Table of Contents Kidney Int
  (Kidney International 102, 6 (2022))
• 00:00
  Title Page Kidney Int
  (Kidney International 102, 6 (2022))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 102, 6 (2022))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 102, 6 (2022))
• 00:00
  KDIGO 2022 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease - Kidney Disease: Improving Global Outcomes (KDIGO) Hepatitis C Work Group Kidney Int
  This article is published as part of a supplement supported by Kidney Disease: Improving Global Outcomes (KDIGO). The development and publication of this guideline were supported by KDIGO. The opinions or views expressed in this professional education supplement are those of the authors and do (...) (Kidney International 102, 6 (2022))

30 November

Kidney Int http://www.kidney-international.org/

• 00:00
  Estimating the prevalence of chronic kidney disease while accounting for nonrandom testing with inverse probability weighting - Faizan Mazhar, Arvid Sjölander, Edouard L. Fu, Johan Ärnlöv, Andrew S. Levey, Josef Coresh, Juan Jesus Carrero Kidney Int
  Chronic kidney disease (CKD) prevalence estimation is central to guiding the medical community and policymakers on where to focus prevention and disease management strategies. Population sources make the estimation of CKD prevalence challenging. In screening cohort studies, healthy individuals (...) (Kidney International 103, 2 (2023))

24 November

Kidney Int http://www.kidney-international.org/

• 00:00
  The pathologic spectrum of adenovirus nephritis in the kidney allograft - Geetha Jagannathan, Astrid Weins, Emily Daniel, Russel J. Crew, Sidney J. Swanson, Glen S. Markowitz, Vivette D. D’Agati, Nicole K. Andeen, Helmut G. Rennke, Ibrahim Batal Kidney Int
  Adenovirus nephritis (ADVN) is a rare and understudied complication of kidney transplantation. Unlike BK virus nephropathy (BKVN), our knowledge of clinicopathologic manifestations of ADVN remains rudimentary and essentially limited to case reports. To expand on this, we retrospectively studied (...) (Kidney International 103, 2 (2023))
• 00:00
  Quantitative scoring of progression in transplant glomerulopathy using digital pathology may be superior to Banff cg scoring - Željko Kiki?, Benjamin A. Adam, Anna Buxeda Porras, Carmen Lefaucheur, Alexandre Loupy, Heinz Regele, Daniel Cejka, Mark Haas, Robert B. Colvin, Michael Mengel Kidney Int
  Antibody-mediated rejection (ABMR) is a major cause of kidney allograft failure. Biopsy-based surrogate endpoints reflecting ABMR progression on sequential biopsies that predict long-term outcome offer the potential to make treatment trials for ABMR feasible. However, the Banff transplant (...) (Kidney International 103, 2 (2023))
• 00:00
  Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis - Laura H. Mariani, Sean Eddy, Fadhl M. AlAkwaa, Phillip J. McCown, Jennifer L. Harder, Viji Nair, Felix Eichinger, Sebastian Martini, Adebowale D. Ademola, Vincent Boima, Heather N. Reich, Jamal El Saghir, Bradley Godfrey, Wenjun Ju, Emily C. Tanner, Virginia Vega-Warner, Noel L. Wys, Sharon G. Adler, Gerald B. Appel, Ambarish Athavale, Meredith A. Atkinson, Serena M. Bagnasco, Laura Barisoni, Elizabeth Brown, Daniel C. Cattran, Gaia M. Coppock, Katherine M. Dell, Vimal K. Derebail, Fernando C. Fervenza, Alessia Fornoni, Crystal A. Gadegbeku, Keisha L. Gibson, Laurence A. Greenbaum, (...) Kidney Int
  The diagnosis of nephrotic syndrome relies on clinical presentation and descriptive patterns of injury on kidney biopsies, but not specific to underlying pathobiology. Consequently, there are variable rates of progression and response to therapy within diagnoses. Here, an unbiased (...) (Kidney International (2022))
• 00:00
  Transitional B cell cytokines risk stratify early borderline rejection after renal transplantation - Aravind Cherukuri, Khodor I. Abou-Daya, Raad Chowdhury, Rajil B. Mehta, Sundaram Hariharan, Parmjeet Randhawa, David M. Rothstein Kidney Int
  Borderline rejection (BL) in renal transplantation is associated with decreased allograft survival, yet many patients with BL maintain stable graft function. Identifying patients with early BL at risk for shortened allograft survival would allow for timely targeted therapeutic intervention (...) (Kidney International (2022))

7 November

Kidney Int http://www.kidney-international.org/

• 00:00
  Viral associations with kidney disease diagnosis and altered kidney metatranscriptome by kidney function - Changjin Hong, Felix Eichinger, Mohamed G. Atta, Michelle M. Estrella, Derek M. Fine, Michael J. Ross, Christina Wyatt, Tae Hyun Hwang, Matthias Kretzler, John R. Sedor, John F. O’Toole, Aaron W. Miller, Leslie A. Bruggeman Kidney Int
  Common causes of nephrotic syndrome are known to have immune or autoimmune components and are treated with immunosuppression. However, for many of these kidney diseases, the initiating pathogenic event remains unknown. Recently, the combined use of next-generation sequencing and pathogen (...) (Kidney International 103, 1 (2023))

2 November

Kidney Int http://www.kidney-international.org/

• 00:00
  A macrophage-endothelial immunoregulatory axis ameliorates septic acute kidney injury - Jamie R. Privratsky, Shintaro Ide, Yanting Chen, Hiroki Kitai, Jiafa Ren, Helene Fradin, Xiaohan Lu, Tomokazu Souma, Steven D. Crowley Kidney Int
  The most common cause of acute kidney injury (AKI) in critically ill patients is sepsis. Kidney macrophages consist of both F4/80hi and CD11bhi cells. The role of macrophage subpopulations in septic AKI pathogenesis remains unclear. As F4/80hi macrophages are reported to contribute to (...) (Kidney International (2022))

1 November

Kidney Int http://www.kidney-international.org/

• 00:00
  Unique problems for the design of the first trials of transplanting porcine kidneys into humans - Peter P. Reese, Bruce E. Gelb, Brendan Parent Kidney Int
  Over the past year, 3 scientific teams conducted experiments of genetically edited porcine organs into human recipients, 3 of whom were deceased and 1 living. In this editorial, we describe challenges for the design of initial xenotransplantation clinical trials and focus on patient selection, (...) (Kidney International 103, 2 (2023))
• 00:00
  The oxidative phosphorylation inhibitor IM156 suppresses B-cell activation by regulating mitochondrial membrane potential and contributes to the mitigation of systemic lupus erythematosus - Joo Sung Shim, Eun Jee Kim, Lucy Eunju Lee, Joon Ye Kim, Yuri Cho, Hanna Kim, Jieun Kim, Sung Hoon Jang, Jimin Son, Jae-Ho Cheong, Aekyong Kim, Beom Jin Lim, Sang-Jun Ha, Jason Jungsik Song, Beom Seok Kim Kidney Int
  Current treatment strategies for autoimmune diseases may not sufficiently control aberrant metabolism in B-cells. To address this concern, we investigated a biguanide derivative, IM156, as a potential regulator for B-cell metabolism in vitro and in vivo on overactive B-cells stimulated by the (...) (Kidney International 103, 2 (2023))
• 00:00
  SARS-CoV-2 vaccination improves HBV seroconversion rate through heterological immunity - Moritz Anft, Krystallenia Paniskaki, Tina Giglio, Jacqueline Wellenkötter, Arturo Blazquez-Navarro, Toni L. Meister, Toralf Roch, Claudia Giesecke-Thiel, Timm H. Westhoff, Ulrik Stervbo, Stephanie Pfaender, Okan Cinkilic, Nina Babel Kidney Int
  Epidemiologic studies in humans and experimental animal data have clearly demonstrated that exposure or infection with one pathogen can induce and/or modify the immune response against another unrelated pathogen.1,2 The mechanism of this phenomenon, known as heterologous immunity, has not been (...) (Kidney International 103, 1 (2023))
• 00:00
  A Banff-based histologic chronicity index is associated with graft loss in patients with a kidney transplant and antibody-mediated rejection - Mark Haas, James Mirocha, Edmund Huang, Reiad Najjar, Alice Peng, Supreet Sethi, Ashley Vo, Dany Anglicheau, Stanley C. Jordan, Marion Rabant Kidney Int
  Antibody-mediated rejection (AMR) is the major cause of graft loss in kidney transplant recipients. The Banff classification defines two classes of AMR, active and chronic active but over time this classification has become increasingly complex. To simplify the approach to AMR, we developed (...) (Kidney International 103, 1 (2023))

31 October

Kidney Int http://www.kidney-international.org/

• 00:00
  Kidney tubular transcription co-activator, Yes-associated protein 1 (YAP), controls the expression of collecting duct aquaporins and water homeostasis - Yu Zhang, Huihui Huang, Yonglun Kong, Chunhua Xu, Liujiang Dai, Xiaoqiang Geng, Yujie Deng, Yang Wang, Yang Liu, Chenling Meng, Xiaoyi Zhang, Jinhong Li, Jinzhong Qin, Bo Feng, Kingston Kinglun Mak, Li Wang, Yu Huang, Weidong Wang, Hui-Yao Lan, Baoxue Yang, Hua A. Jenny Lu, Yin Xia Kidney Int
  Final urine volume and concentration are defined by water reabsorption through the water channel proteins aquaporin (AQP)-2, -3 and -4 in the collecting duct. However, the transcriptional regulation of these AQPs is not well understood. The Hippo/Yes-associated protein 1 (YAP) pathway plays an (...) (Kidney International (2022))

29 October

Kidney Int http://www.kidney-international.org/

• 00:00
  A genomic deep field view of hypertension - Pranav S. Garimella, Clea du Toit, Nhu Ngoc Le, Sandosh Padmanabhan Kidney Int
  Blood pressure is regulated by a complex neurohumoral system including the renin-angiotensin-aldosterone system, natriuretic peptides, endothelial pathways, the sympathetic nervous system, and the immune system. This review charts the evolution of our understanding of the genomic basis of (...) (Kidney International 103, 1 (2023))

27 October

Kidney Int http://www.kidney-international.org/

• 00:00
  Longitudinal assessment of the health-related quality of life of children and adolescents with chronic kidney disease - Chandana Guha, Anita van Zwieten, Rabia Khalid, Siah Kim, Amanda Walker, Anna Francis, Madeleine Didsbury, Armando Teixeira-Pinto, Belinda Barton, Chanel Prestidge, Emily Lancsar, Fiona Mackie, Joseph Kwon, Kirsten Howard, Kylie-Ann Mallitt, Martin Howell, Allison Jaure, Alison Hayes, Rakhee Raghunandan, Stavros Petrou, Suncica Lah, Steven McTaggart, Jonathan C. Craig, Germaine Wong Kidney Int
  In this multi-center longitudinal cohort study conducted in Australia and New Zealand, we assessed the trajectories of health-related quality of life (HRQoL) in children with chronic kidney disease (CKD) over time. A total of 377 children (aged 6-18 years) with CKD stages 1-5 (pre-dialysis), (...) (Kidney International 103, 2 (2023))
• 00:00
  Hematopoietic-specific melanocortin 1 receptor signaling protects against nephrotoxic serum nephritis and mediates the beneficial effect of melanocortin therapy - Xuejing Guan, Bohan Chen, Deepak K. Malhotra, Amira F. Gohara, Lance D. Dworkin, Rujun Gong Kidney Int
  The melanocortin hormone system has emerged as a novel therapeutic target for treating refractory glomerular diseases. However, the role of hematopoietic melanocortin 1 receptor (MC1R) signaling remains unknown. Upon insult by rabbit nephrotoxic serum, MC1R null-mutant mice developed more (...) (Kidney International 103, 2 (2023))
• 00:00
  Effects of aspirin on cardiovascular outcomes in patients with chronic kidney disease - Johannes F.E. Mann, Philip Joseph, Peggy Gao, Prem Pais, Jessica Tyrwhitt, Denis Xavier, Tony Dans, Patricio Lopez Jaramillo, Habib Gamra, Salim Yusuf, the TIPS-3 investigators Kidney Int
  Patients with chronic kidney disease (CKD) carry a high cardiovascular (CV) risk. Since whether this risk is reduced by aspirin is unclear, we examined if the effect of aspirin on cardiovascular outcomes varied by baseline kidney function in a primary cardiovascular disease prevention trial. (...) (Kidney International 103, 2 (2023))
• 00:00
  Anomalous kinetics of galactose-deficient IgA incurring nephropathy revealed by cross-scale optical imaging - Meijun Si, Lanqing Li, Mengting Fang, Zhiming Ye, Xu-chao Zhang, Wei Yang, Liming Nie, Xueqing Yu Kidney Int
  IgA nephropathy (IgAN) is the most common glomerulonephritis, characterized by the presence of predominant IgA deposits in the mesangium. Deposition of pathogenic IgA in kidney tissue is a fundamental initiating process that has not been fully studied. Here, we employed optical imaging to (...) (Kidney International 103, 2 (2023))
• 00:00
  A prespecified exploratory analysis from FIDELITY examined finerenone use and kidney outcomes in patients with chronic kidney disease and type 2 diabetes - George L. Bakris, Luis M. Ruilope, Stefan D. Anker, Gerasimos Filippatos, Bertram Pitt, Peter Rossing, Linda Fried, Prabir Roy-Chaudhury, Pantelis Sarafidis, Christiane Ahlers, Meike Brinker, Amer Joseph, Robert Lawatscheck, Rajiv Agarwal, FIDELIO-DKD and FIGARO-DKD Investigators Kidney Int
  In FIDELITY, a prespecified pooled analysis of the FIDELIO-DKD and FIGARO-DKD studies, finerenone was found to improve cardiorenal outcomes in patients with type 2 diabetes, a urine albumin-to-creatinine ratio of 30–5000 mg/g, an estimated glomerular filtration rate (eGFR) of 25 ml/min per 1.73 (...) (Kidney International 103, 1 (2023))
• 00:00
  Uncovering risk factors for kidney injury in children with a solitary functioning kidney - Sander Groen in ‘t Woud, Nel Roeleveld, Rik Westland, Kirsten Y. Renkema, Martijn G. Steffens, Valentina Gracchi, Marc R. Lilien, Joanna A.E. van Wijk, Wout F.J. Feitz, Michiel F. Schreuder, Loes F.M. van der Zanden, Solitary Functioning Kidney: Aetiology and Prognosis (SOFIA) study group Kidney Int
  Children with a solitary functioning kidney (SFK) have an increased risk of kidney injury. The exact risk of and risk factors for kidney injury remain unknown, which impedes personalized care. Here, we recruited a nationwide multicenter cohort of 944 patients with SFK to get more insight into (...) (Kidney International 103, 1 (2023))
• 00:00
  Clinical phenotypes and long-term outcome of kidney involvement in Erdheim-Chester histiocytosis - Thibaud Chazal, Francesco Pegoraro, Gaia Manari, Alessandra Bettiol, Valerio Maniscalco, Elena Gelain, Frédéric Charlotte, Roei D. Mazor, Raphaele Renard-Penna, Zahir Amoura, Fleur Cohen-Aubart, Julien Haroche, Hassan Izzedine, Augusto Vaglio Kidney Int
  Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis that frequently infiltrates the peri-kidney space (“hairy kidney” appearance), kidney pelvis and proximal ureters, leading to obstructive uropathy. Here, we analyzed the clinical characteristics, imaging findings and (...) (Kidney International 103, 1 (2023))
• 00:00
  Association between cholinesterase inhibitors and kidney function decline in patients with Alzheimer’s dementia - Hong Xu, Sara Garcia-Ptacek, Annette Bruchfeld, Edouard L. Fu, Taher Darreh Shori, Bengt Lindholm, Maria Eriksdotter, Juan Jesus Carrero Kidney Int
  Preclinical evidence shows that activation of the cholinergic anti-inflammatory pathway (CAP) may have direct and indirect beneficial effects on the kidney. Cholinesterase inhibitors (ChEIs) are specific Alzheimer’s dementia (AD) therapies that block the action of cholinesterases and activate (...) (Kidney International 103, 1 (2023))

26 October

Kidney Int http://www.kidney-international.org/

• 00:00
  CD248 induces a maladaptive unfolded protein response in diabetic kidney disease - Shruthi Krishnan, Jayakumar Manoharan, Hongjie Wang, Dheerendra Gupta, Sameen Fatima, Yanfei Yu, Akash Mathew, Zhen Li, Shrey Kohli, Constantin Schwab, Antje Körner, Peter R. Mertens, Peter Nawroth, Khurrum Shahzad, Michael Naumann, Berend Isermann, Ronald Biemann Kidney Int
  Dysfunction of mesangial cells plays a major role in the pathogenesis of diabetic kidney disease (DKD), the leading cause of kidney failure. However, the underlying molecular mechanisms are incompletely understood. By unbiased gene expression analysis of glucose-exposed mesangial cells, we (...) (Kidney International 103, 2 (2023))

25 October

Kidney Int http://www.kidney-international.org/

• 00:00
  On the way to translate GWAS into kidney disease mechanisms - Olivier Devuyst, Krzysztof Kiryluk Kidney Int
  Chronic kidney disease (CKD) is a global public health burden, affecting as many as 10% to 15% of the population worldwide and >20% of individuals older than 60 years.1 Elucidating the mechanisms underlying genetic effects on kidney function and propensity to develop CKD will be critical to (...) (Kidney International 103, 1 (2023))
• 00:00
  A Phase I/IIa study of autologous tolerogenic dendritic cells immunotherapy in kidney transplant recipients - Aurélie Moreau, Delphine Kervella, Laurence Bouchet-Delbos, Cécile Braudeau, Soraya Saïagh, Pierrick Guérif, Sophie Limou, Anne Moreau, Sylvain Bercegeay, Mathias Streitz, Birgit Sawitzki, Ben James, Paul N. Harden, David Game, Qizhi Tang, James F. Markmann, Ian S.D. Roberts, Edward K. Geissler, Brigitte Dréno, Régis Josien, Maria-Cristina Cuturi, Gilles Blancho, the DIVAT consortium Kidney Int
  Kidney transplant survival is shortened by chronic rejection and side effects of standard immunosuppressive drugs. Cell-based immunotherapy with tolerogenic dendritic cells has long been recognized as a promising approach to reduce general immunosuppression. Published trials report the safety (...) (Kidney International (2022))

22 October

Kidney Int http://www.kidney-international.org/

• 00:00
  Enhancer and super-enhancer landscape in polycystic kidney disease - Ronak Lakhia, Abheepsa Mishra, Laurence Biggers, Venkat Malladi, Patricia Cobo-Stark, Sachin Hajarnis, Vishal Patel Kidney Int
  Widespread aberrant gene expression is a pathological hallmark of polycystic kidney disease (PKD). Numerous pathogenic signaling cascades, including c-Myc, Fos, and Jun, are transactivated. However, the underlying epigenetic regulators are poorly defined. Here we show that H3K27ac, an (...) (Kidney International 103, 1 (2023))

21 October

Kidney Int http://www.kidney-international.org/

• 00:00
  Defining measures of kidney function in observational studies using routine health care data: methodological and reporting considerations - Juan Jesus Carrero, Edouard L. Fu, Søren V. Vestergaard, Simon Kok Jensen, Alessandro Gasparini, Viyaasan Mahalingasivam, Samira Bell, Henrik Birn, Uffe Heide-Jørgensen, Catherine M. Clase, Faye Cleary, Josef Coresh, Friedo W. Dekker, Ron T. Gansevoort, Brenda R. Hemmelgarn, Kitty J. Jager, Tazeen H. Jafar, Csaba P. Kovesdy, Manish M. Sood, Bénédicte Stengel, Christian F. Christiansen, Masao Iwagami, Dorothea Nitsch Kidney Int
  The availability of electronic health records and access to a large number of routine measurements of serum creatinine and urinary albumin enhance the possibilities for epidemiologic research in kidney disease. However, the frequency of health care use and laboratory testing is determined by (...) (Kidney International 103, 1 (2023))

20 October

Kidney Int http://www.kidney-international.org/

• 00:00
  Myofibroblast depletion reduces kidney cyst growth and fibrosis in autosomal dominant polycystic kidney disease - Nidhi Dwivedi, Abeda Jamadar, Sijo Mathew, Timothy A. Fields, Reena Rao Kidney Int
  Autosomal dominant polycystic kidney disease (ADPKD) involves the development and persistent growth of fluid filled kidney cysts. In a recent study, we showed that ADPKD kidney cyst epithelial cells can stimulate the proliferation and differentiation of peri-cystic myofibroblasts. Although (...) (Kidney International 103, 1 (2023))

18 October

Kidney Int http://www.kidney-international.org/

• 00:00
  Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial, which evaluated targeted-release formulation of budesonide for the treatment of primary immunoglobulin A nephropathy - Jonathan Barratt, Richard Lafayette, Jens Kristensen, Andrew Stone, Daniel Cattran, Jürgen Floege, Vladimir Tesar, Hernán Trimarchi, Hong Zhang, Necmi Eren, Alexander Paliege, Brad H. Rovin, NefIgArd Trial Investigators Kidney Int
  The therapeutic potential of a novel, targeted-release formulation of oral budesonide (Nefecon) for the treatment of IgA nephropathy (IgAN) was first demonstrated by the phase 2b NEFIGAN trial. To verify these findings, the phase 3 NefigArd trial tested the efficacy and safety of nine months of (...) (Kidney International 103, 2 (2023))

5 October

Kidney Int http://www.kidney-international.org/

• 00:00
  False positivity for PLA2R1 antibody measured by ELISA in a nephrotic patient with no membranous nephropathy - Elion Hoxha, Linda Reinhard, Thomas Castedello, Jan U. Becker Kidney Int
  The discovery of autoantibodies against M-type phospholipase A2 receptor (PLA2R1)1 as the main cause of membranous nephropathy (MN) has revolutionized diagnosis, prognostication, and treatment approaches in patients with MN.2 Different assays have been established for the detection of (...) (Kidney International 103, 2 (2023))

30 September

Kidney Int http://www.kidney-international.org/

• 00:00
  Podocyte expression of human phospholipase A2 receptor 1 causes immune-mediated membranous nephropathy in mice - Nicola M. Tomas, Silke Dehde, Catherine Meyer-Schwesinger, Ming Huang, Irm Hermans-Borgmeyer, Johanna Maybaum, Renke Lucas, Jennie L. von der Heide, Oliver Kretz, Sarah M.S. Köllner, Larissa Seifert, Tobias B. Huber, Gunther Zahner Kidney Int
  Antibody-mediated autoimmune pathologies like membranous nephropathy are difficult to model, particularly in the absence of local target antigen expression in model organisms such as mice and rats; as is the case for phospholipase A2 receptor 1 (PLA2R1), the major autoantigen in membranous (...) (Kidney International 103, 2 (2023))

13 September

Kidney Int http://www.kidney-international.org/

• 00:00
  Myeloid expression of the anti-apoptotic protein Mcl1 is required in anti-myeloperoxidase vasculitis but myeloperoxidase inhibition is not protective - Fernanda Florez-Barros, Siobhan Bearder, Bengt Kull, Adrian Freeman, Attila Mócsai, Michael G. Robson Kidney Int
  Antibodies to neutrophil and monocyte myeloperoxidase and proteinase 3 are a feature of anti-neutrophil cytoplasmic antibody vasculitis, a disease with significant morbidity for which new treatments are needed. Mice with a myeloid-specific deletion of the anti-apoptotic protein Mcl1 have (...) (Kidney International 103, 1 (2023))

12 September

Kidney Int http://www.kidney-international.org/

• 00:00
  Human kidney-derived hematopoietic stem cells can support long-term multilineage hematopoiesis - Steicy Sobrino, Chrystelle Abdo, Bénédicte Neven, Adeline Denis, Nathalie Gouge-Biebuyck, Emmanuel Clave, Soëli Charbonnier, Tifanie Blein, Camille Kergaravat, Marion Alcantara, Patrick Villarese, Romain Berthaud, Laurène Dehoux, Souha Albinni, Esma Karkeni, Chantal Lagresle-Peyrou, Marina Cavazzana, Rémi Salomon, Isabelle André, Antoine Toubert, Vahid Asnafi, Capucine Picard, Stéphane Blanche, Elizabeth Macintyre, Olivia Boyer, Emmanuelle Six, Julien (...) Kidney Int
  Long-term multilineage hematopoietic donor chimerism occurs sporadically in patients who receive a transplanted solid organ enriched in lymphoid tissues such as the intestine or liver. There is currently no evidence for the presence of kidney-resident hematopoietic stem cells in any mammal (...) (Kidney International 103, 1 (2023))

7 September

Kidney Int http://www.kidney-international.org/

• 00:00
  Phosphoglycerate mutase 5 initiates inflammation in acute kidney injury by triggering mitochondrial DNA release by dephosphorylating the pro-apoptotic protein Bax - Jingyao Li, Xi’ang Sun, Ninghao Yang, Jiayun Ni, Hongyan Xie, Hengjiang Guo, Xin Wang, Li Zhou, Jun Liu, Sijia Chen, Xiaoxia Wang, Yingying Zhang, Chen Yu, Wei Zhang, Limin Lu Kidney Int
  Acute kidney injury (AKI) is a worldwide public health problem characterized by excessive inflammation with no specific therapy in clinic. Inflammation is not only a feature of AKI but also an essential promoter for kidney deterioration. Phosphoglycerate mutase 5 (PGAM5) was up-regulated and (...) (Kidney International 103, 1 (2023))
• 00:00
  E-prostanoid 3 receptor deficiency on myeloid cells protects against ischemic acute kidney injury via breaking the auto-amplification loop of necroinflammation - Jing Leng, Wen Zhao, Jinwei Guo, Gang Yu, Guanghui Zhu, Jiahui Ge, Dong He, Yineng Xu, Xijian Chen, Yingbi Zhou, Bin Liu Kidney Int
  Necroinflammation plays an important role in disease settings such as acute kidney injury (AKI). We and others have elucidated that prostaglandins, which are critically involved in inflammation, may activate E-prostanoid 3 receptor (EP3) at low concentrations. However, how EP3 blockade (...) (Kidney International 103, 1 (2023))

30 August

Kidney Int http://www.kidney-international.org/

• 00:00
  A comparative study of cellular diversity between the Xenopus pronephric and mouse metanephric nephron - Mark E. Corkins, MaryAnne Achieng, Bridget D. DeLay, Vanja Krneta-Stankic, Margo P. Cain, Brandy L. Walker, Jichao Chen, Nils O. Lindström, Rachel K. Miller Kidney Int
  The kidney is an essential organ that ensures bodily fluid homeostasis and removes soluble waste products from the organism. Nephrons, the functional units of the kidney, comprise a blood filter, the glomerulus or glomus, and an epithelial tubule that processes the filtrate from the blood or (...) (Kidney International 103, 1 (2023))

21 August

Kidney Int http://www.kidney-international.org/

• 00:00
  PHYOX2: a pivotal randomized study of nedosiran in primary hyperoxaluria type 1 or 2 - Michelle A. Baum, Craig Langman, Pierre Cochat, John C. Lieske, Shabbir H. Moochhala, Shuzo Hamamoto, Hiroyuki Satoh, Chebl Mourani, Gema Ariceta, Armando Torres, Martin Wolley, Vladimir Belostotsky, Thomas A. Forbes, Jaap Groothoff, Wesley Hayes, Burkhard Tönshoff, Tatsuya Takayama, Ralf Rosskamp, Kerry Russell, Jing Zhou, Aniruddha Amrite, Bernd Hoppe, PHYOX2 study investigators Kidney Int
  Nedosiran is an investigational RNA interference agent designed to inhibit expression of hepatic lactate dehydrogenase, the enzyme thought responsible for the terminal step of oxalate synthesis. Oxalate overproduction is the hallmark of all genetic subtypes of primary hyperoxaluria (PH). In (...) (Kidney International 103, 1 (2023))

1 August

Kidney Int http://www.kidney-international.org/

• 00:00
  What to do when a child with nephrotic syndrome has a cold? Learning from RCTs - Marina Vivarelli, Elisabeth Hodson Kidney Int
  Nephrotic syndrome in children is a relapsing condition with a course that frequently lasts for many years. While steroid-sensitive forms rarely, if ever, lead to impairment of kidney function, the protracted use of different forms of immunosuppression to prevent relapses can be associated with (...) (Kidney International 102, 2 (2022))
• 00:00
  Acute kidney injury and “clogged chimneys” - Saban Elitok, Nilüfer Tekceli, Maxim Nebrig Kidney Int
  A 65-year-old man presented with rectal bleeding for 2 weeks, progressive dyspnea, dark urine, and decreased urinary output. Laboratory evaluation showed a plasma creatinine level of 1458 ?mol/L, a potassium level of 7.0 mmol/L, and a hemoglobin level of 4.6 mmol/L. Endoscopy showed gastritis (...) (Kidney International 102, 2 (2022))
• 00:00
  Bilateral renal lymphangiectasia - Yann Cerba, Marie Michoud, Ophélie Dos Santos, Emmanuel Forestier, Mélanie Loock, Jacques Fourcade Kidney Int
  A 34-year-old woman with hypertension and a perirenal left drain fitted 2 months earlier for acute left flank pain had a body temperature of 39 °C. Laboratory data showed leukocytes 9.9 G/l, C-reactive protein 140 mg/l, and serum creatinine 57 ?mol/l. Analysis of the yellowish fluid in the drain (...) (Kidney International 102, 2 (2022))
• 00:00
  A farmer’s child with kidney failure - Dhirendra Pratap Singh, Maninder Dhaliwal, Veena Raghunathan, Ananya Vadhera, Arvind Kumar, Shyam Bihari Bansal, Pranaw Kumar Jha, Rupesh Raina, Sidharth Kumar Sethi Kidney Int
  A 5-year-old boy from a farming family was brought to the emergency department with abdominal pain and vomiting for 3 days, dysentery for 2 days, and breathing difficulty and hematemesis for 1 day before admission. On evaluation, the child was diagnosed with multiorgan dysfunction syndrome (...) (Kidney International 102, 2 (2022))
• 00:00
  Table of Contents Kidney Int
  (Kidney International 102, 2 (2022))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 102, 2 (2022))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 102, 2 (2022))
• 00:00
  Recognizing the true face of noninfectious cryoglobulinemic glomerulonephritis - Xiao-juan Yu, Su-xia Wang Kidney Int
  Cryoglobulinemia encompasses a group of diseases with circulating aberrant Igs, which can cause systemic cryoglobulinemic vasculitis, including cryoglobulinemic glomerulonephritis. The complexities of different types and changing etiologies of cryoglobulinemias determine its heterogeneous (...) (Kidney International 102, 2 (2022))
• 00:00
  In remembrance of Arthur H. Cohen, MD (1942–2022) - Cynthia C. Nast, Richard Glassock Kidney Int
  Arthur H. Cohen, MD, Professor of Pathology at Cedars-Sinai Medical Center and Wake Forest University School of Medicine and Professor of Pathology and Medicine at David Geffen School of Medicine at UCLA, passed away on May 17, 2022, at the age of 80 years. A leader in the development of kidney (...) (Kidney International 102, 2 (2022))
• 00:00
  In this Issue Kidney Int
  Despite frequent use of renin angiotensin aldosterone system (RAAS) inhibitors in adults with lupus nephritis (LN), the evidence for RAAS inhibition in disease management of children with LN is sparse. Chang et al. examined Medicaid and commercial insurance databases to understand how the use (...) (Kidney International 102, 2 (2022))
• 00:00
  Journal Club Kidney Int
  Brown et al. (Nature. 2022;605:349–356.) (Kidney International 102, 2 (2022))
• 00:00
  The fate of erythropoietin-producing cells: another piece of the puzzle - Michaela A.A. Fuchs, Armin Kurtz Kidney Int
  In this issue, Kaneko et al. reported the generation of a mouse line that allows for the labeling of cells under control of the erythropoietin (Epo) gene promotor. The authors show that Epo-producing cells become proliferating, profibrotic cells after kidney injury and lose their ability to (...) (Kidney International 102, 2 (2022))
• 00:00
  Proteomic discovery in diabetic kidney disease—to what end? - Eugene P. Rhee Kidney Int
  Emerging approaches that enable high-throughput analysis of the plasma proteome have been increasingly deployed in nephrology research. Kobayashi et al. provide a valuable addition to this literature, describing an untargeted proteomic analysis of diabetic kidney disease progression to (...) (Kidney International 102, 2 (2022))
• 00:00
  The authors reply: - Nizar Joher, Anissa Moktefi, Philippe Grimbert, Eléonore Pagot, Narindra Jouan, Khalil El Karoui, Cécile Maud Champy, Marie Matignon, Thomas Stehlé Kidney Int
  We thank Metry et al.1 for their interest in our letter.2 These authors suggested that our letter title did not reflect clinical reality and might be misinterpreted. They believe that the increase in creatinine was merely caused by rejection rather than by oxalate nephropathy, and that it was (...) (Kidney International 102, 2 (2022))
• 00:00
  The appearance of oxalate crystals in a kidney biopsy is no proof of post-transplant oxalate nephropathy in primary hyperoxaluria type 1 - Elisabeth L. Metry, Michiel J.S. Oosterveld, Jaap W. Groothoff, Justine Bacchetta Kidney Int
  We read with interest the letter by Joher et al.: “Early Post-transplant Recurrence of Oxalate Nephropathy in a Patient With Primary Hyperoxaluria Type 1, Despite Pretransplant Lumasiran Therapy.”1 (Kidney International 102, 2 (2022))
• 00:00
  Corrigendum to Zhang J, Cai J, Cui Y, Jiang S, Wei J, Kim YC, Chan J, Thalakola A, Le T, Xu L, Wang L, Jiang K, Wang X, Wang H, Cheng F, Buggs J, Koepsell H, Vallon V, Liu R. “Role of the macula densa sodium glucose cotransporter type 1-neuronal nitric oxide synthase-tubuloglomerular feedback pathway in diabetic hyperfiltration.” Kidney Int. 2022;101:541–550 - Jie Zhang, Jing Cai, Yu Cui, Shan Jiang, Jin Wei, Young Chul Kim, Jenna Chan, Anish Thalakola, Thanh Le, Lan Xu, Lei Wang, Kun Jiang, Ximing Wang, Haibo Wang, Feng Cheng, Jacentha Buggs, Hermann Koepsell, Volker Vallon, Ruisheng Liu Kidney Int
  In the above-stated article, the affiliation 2 for Jing Cai and Haibo Wang is incorrect. The correct affiliation is “2Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, (...) (Kidney International 102, 2 (2022))
• 00:00
  Antigen-specific B cells in kidney transplantation - Johnny Bou Saba, Aravind Cherukuri Kidney Int
  In this issue, Burton et al. describe a convincing method to identify and enumerate human leukocyte antigen–specific B cells and subsets using biotinylated human leukocyte antigen proteins. Importantly, they demonstrate that these antigen-specific B cells are found at a greater frequency in (...) (Kidney International 102, 2 (2022))
• 00:00
  The art and science of the possible in glomerular filtration rate measurement - David J.A. Goldsmith Kidney Int
  Delanaye, Pottel, and Glassock’s editorial1 sensitively and succinctly articulates one of the cardinal problems that besets kidney medicine also known as nephrology today. If one cannot define how, when, and in whom to measure kidney function (and what constitutes an expected healthy-ageing (...) (Kidney International 102, 2 (2022))
• 00:00
  Do the benefits of subcutaneous immunoglobulin therapy for secondary hypogammaglobulinemia in ANCA vasculitis extend beyond infection prevention? - Bryce M. Churilla, Faten Aqeel, Antoine Azar, Brendan Antiochos, Philip Seo, David B. Hellmann, Duvuru Geetha Kidney Int
  Antineutrophil cytoplasmic autoantibody–associated vasculitides (AAV) are necrotizing small-vessel vasculitides characterized by a relapsing course. Rituximab is recommended for both remission induction and maintenance in AAV.1 Hypogammaglobulinemia is being increasingly recognized with over 50% (...) (Kidney International 102, 2 (2022))
• 00:00
  Heparin, klotho, and FGF23: the 3-beat waltz of the discordant heart - Marta Martinez-Calle, Valentin David Kidney Int
  Excess fibroblast growth factor (FGF) 23 signaling in patients with chronic kidney disease induces left ventricular hypertrophy. In this issue, Yanucil et al. investigated the interaction of soluble klotho and heparin with FGF23 and FGF receptor isoforms. They concluded that heparin promotes (...) (Kidney International 102, 2 (2022))

20 July

Kidney Int http://www.kidney-international.org/

• 00:00
  Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension. - Aditya Surapaneni, Pascal Schlosser, Linda Zhou, Celina Liu, Nilanjan Chatterjee, Dan E. Arking, Diptavo Dutta, Josef Coresh, Eugene P. Rhee, Morgan E. Grams Kidney Int
  Investigations into the causal underpinnings of disease processes can be aided by the incorporation of genetic information. Genetic studies require populations varied in both ancestry and prevalent disease in order to optimize discovery and ensure generalizability of findings to the global (...) (Kidney International (2022))
• 00:00
  Novel gold-platinum nanoparticles serve as broad-spectrum antioxidants for attenuating ischemia reperfusion injury of the kidney. - Shijian Feng, Ying Qu, Bingyang Chu, Xiaoting Chen, Ziyan Yang, Peiwen Li, Peiyu Wang, Qiyu He, Yushi He, Tao Lin, Zhongli Huang, Zhiyong Qian Kidney Int
  Kidney ischemia reperfusion injury (IRI) is a common and inevitable pathological condition in routine urological practices, especially during transplantation. Severe kidney IRI may even induce systemic damage to peripheral organs, and lead to multisystem organ failure. However, no standard (...) (Kidney International (2022))
• 00:00
  Multiple molecular mechanisms are involved in the activation of the kidney sodium-chloride cotransporter by hypokalemia. - Adrián R. Murillo-de-Ozores, Héctor Carbajal-Contreras, Germán R. Magaña-Ávila, Raquel Valdés, Leoneli I. Grajeda-Medina, Norma Vázquez, Teresa Zariñán, Alejandro López-Saavedra, Avika Sharma, Dao-Hong Lin, Wen-Hui Wang, Eric Delpire, David H. Ellison, Gerardo Gamba, María Castañeda-Bueno Kidney Int
  Low potassium intake activates the kidney sodium-chloride cotransporter, NCC, whose phosphorylation and activity depend on the With-No-Lysine kinase 4 (WNK4) that is inhibited by chloride binding to its kinase domain. Low extracellular potassium activates NCC by decreasing intracellular (...) (Kidney International (2022))
• 00:00
  Covid-19 morbidity decreases with Tixagevimab/cilgavimab preexposure prophylaxis in kidney transplant recipients non/low vaccine responders. - Hannah Kaminski, Mickael Gigan, Agathe Vermorel, Manon Charrier, Laura Guirle, Frederic Jambon, Arthur Lacapère, Coline Ménard, Karine Moreau, Martine Neau-Cransac, Marine Novion, Frederique Pribat, Benjamin Taton, Sébastien Borde, Laure Burguet, Charlie Martinez, Magali Jasiek, Pauline D’Halluin, Marie-Edith Lafon, Pierre Merville, Lionel Couzi Kidney Int
  SARS-Cov-2 infection is associated with high mortality in kidney transplant recipients (KTRs)1. Unfortunately, they display a poor humoral immune response following Covid-19 mRNA vaccination2. The use of anti-SARS-CoV-2 monoclonal antibodies was therefore proposed for pre-exposure prophylaxis (...) (Kidney International (2022))
• 00:00
  The kidney matrisome in health, aging and disease - Franziska Lausecker, Rachel Lennon, Michael J. Randles Kidney Int
  Dysregulated extracellular matrix is the hallmark of fibrosis, and it has a profound impact on kidney function in disease. Furthermore, perturbation of matrix homeostasis is a feature of aging and is associated with declining kidney function. Understanding these dynamic processes, in the hope (...) (Kidney International (2022))

19 July

Kidney Int http://www.kidney-international.org/

• 00:00
  The impact of dietary nutrient intake on gut microbiota in the progression and complications of chronic kidney disease - Laetitia Koppe, Christophe O. Soulage Kidney Int
  Chronic kidney disease (CKD) has been associated with changes in the function and composition of the gut microbiota. The ecosystem of the human gut consists of trillions of microorganisms forming an authentic metabolically active organ that is fueled by nutrients to produce bioactive compounds. (...) (Kidney International (2022))

18 July

Kidney Int http://www.kidney-international.org/

• 00:00
  A randomized controlled pilot trial of anakinra for hemodialysis inflammation - Laura M. Dember, Adriana Hung, Rajnish Mehrotra, Jesse Y. Hsu, Dominic S. Raj, David M. Charytan, Finnian R. Mc Causland, Renu Regunathan-Shenk, J. Richard Landis, Paul L. Kimmel, Alan S. Kliger, Jonathan Himmelfarb, T. Alp Ikizler Kidney Int
  Chronic inflammation is highly prevalent among patients receiving maintenance hemodialysis and is associated with morbidity and mortality. Inhibiting inflammation with anti-cytokine therapy has been proposed but not well studied in this population. Therefore, we conducted the ACTION trial, a (...) (Kidney International (2022))

15 July

Kidney Int http://www.kidney-international.org/

• 00:00
  Lipidomic profiling in the Strong Heart Study identified American Indians at risk of chronic kidney disease. - Wenjie Zeng, Habtamu B. Beyene, Mikko Kuokkanen, Guanhong Miao, Dianna J. Magliano, Jason G. Umans, Nora Franceschini, Shelley A. Cole, George Michailidis, Elisa T. Lee, Barbara V. Howard, Oliver Fiehn, Joanne E. Curran, John Blangero, Peter J. Meikle, Jinying Zhao Kidney Int
  Dyslipidemia associates with and usually precedes the onset of chronic kidney disease (CKD), but a comprehensive assessment of molecular lipid species associated with risk of CKD is lacking. Here, we sought to identify fasting plasma lipids associated with risk of CKD among American Indians in (...) (Kidney International (2022))
• 00:00
  TARGETING INFLAMMATORY MONOCYTES BY IMMUNE-MODIFYING NANOPARTICLES PREVENTS ACUTE KIDNEY ALLOGRAFT REJECTION - Christina Lai, Steven Chadban, Yik Wen Loh, Tony Kwan, Chuanmin Wang, Julian Singer, Paula Niewold, Zheng Ling, Alanna Spiteri, Daniel Getts, Nicholas King, Huiling Wu Kidney Int
  Migration of inflammatory monocytes from circulation into the allograft is an early and critical event in the innate response that leads to kidney inflammation, allo-immunity and ultimately acute rejection. To date, therapies specifically targeting inflammatory monocytes in human kidney (...) (Kidney International (2022))
• 00:00
  HIV at 40: Kidney Disease in HIV Treatment, Prevention, and Cure - Anika Lucas, Christina M. Wyatt Kidney Int
  Four decades after the first cases of HIV were reported, kidney disease remains an important comorbidity in people with HIV (PWH). Both HIV-associated nephropathy and immune complex kidney disease were recognized as complications of HIV infection in the early years before treatment was (...) (Kidney International (2022))

13 July

Kidney Int http://www.kidney-international.org/

• 00:00
  The next step in chronic kidney disease staging: individualized risk prediction - Rupert W. Major, Paul Cockwell, Dorothea Nitsch, Navdeep Tangri Kidney Int
  Chronic kidney disease (CKD) stage-based classification has been used as a framework for clinical practice, public health, and research for the last 20 years.1 Categorization of risk, utilizing estimated glomerular filtration rate (eGFR) and proteinuria measurement, has become an important part (...) (Kidney International (2022))

7 July

Kidney Int http://www.kidney-international.org/

• 00:00
  Novel retinal vascular phenotypes for the potential assessment of long-term risk in living kidney donors - Ylenia Giarratano, Dan Pugh, Tariq E. Farrah, Gabriel C. Oniscu, Thomas J. MacGillivray, Baljean Dhillon, Neeraj Dhaun, Miguel O. Bernabeu Kidney Int
  Chronic kidney disease (CKD) has a global prevalence of ?10% and is independently associated with incident cardiovascular disease (CVD).1 The risk of CVD increases as estimated glomerular filtration rate (eGFR) declines and is highest in those with kidney failure.1 Kidney transplantation (...) (Kidney International (2022))

1 July

Kidney Int http://www.kidney-international.org/

• 00:00
  Molecular profiling of kidney compartments from serial biopsies differentiate treatment responders from non-responders in lupus nephritis - Samir V. Parikh, Ana Malvar, Huijuan Song, John Shapiro, Juan Manuel Mejia-Vilet, Isabelle Ayoub, Salem Almaani, Sethu Madhavan, Valeria Alberton, Celeste Besso, Bruno Lococo, Anjali Satoskar, Jianying Zhang, Lianbo Yu, Paolo Fadda, Michael Eadon, Dan Birmingham, Latha P. Ganesan, Wael Jarjour, Brad H. Rovin Kidney Int
  The immune pathways that define treatment response and non-response in lupus nephritis (LN) are unknown. To characterize these intra-kidney pathways, transcriptomic analysis was done on protocol kidney biopsies obtained at flare (initial biopsy (Bx1)) and after treatment (second biopsy (Bx2)) (...) (Kidney International (2022))
• 00:00
  Table of Contents Kidney Int
  (Kidney International 102, 1 (2022))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 102, 1 (2022))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 102, 1 (2022))
• 00:00
  Erratum to Kudose S, Lipton M, Jain NG, D’Agati VD. “Valproic acid–associated proximal tubulopathy.” Kidney Int. 2022;101:653 Kidney Int
  In the above-stated article, the sentence “Next generation sequencing of the mitochondrial genome failed to detect any pathogenic variants.” was not included in the third paragraph of the article, after the description of Figure 1b. Here is the paragraph with the sentence (...) (Kidney International 102, 1 (2022))
• 00:00
  The authors reply - Enric Vilar, Raja M. Kaja Kamal, James Fotheringham, Amanda Busby, Jocelyn Berdeprado, Ewa Kislowska, David Wellsted, Bassam Alchi, James O. Burton, Andrew Davenport, Ken Farrington Kidney Int
  We acknowledge the comments by Torreggiani et al.1 on our feasibility randomized controlled trial of incremental dialysis2 regarding the timing of initiating incremental dialysis. We randomized patients within 3 months of initiating hemodialysis rather than from day 1. The question is whether (...) (Kidney International 102, 1 (2022))
• 00:00
  In this issue Kidney Int
  Fabry disease results from a deficiency of the enzyme galactosidase-A (GLA), leading to accumulation of its substrates, primarily globotriaosylceramide (GL3) in various cells, including podocytes. As the disease is X-linked, males are severely affected, and all podocytes have the Fabry (...) (Kidney International 102, 1 (2022))
• 00:00
  Impact of APOL1 kidney risk variants on glomerular transcriptomes - Jeffrey B. Kopp, Jurgen Heymann Kidney Int
  McNulty and colleagues describe the glomerular transcriptional landscape of subjects with APOL1 (the gene encoding apolipoprotein L1)–associated kidney disease, using bulk RNA sequencing. They found the following: APOL1 gene expression was higher in individuals with APOL1 high-risk genetic (...) (Kidney International 102, 1 (2022))
• 00:00
  Journal Club Kidney Int
  Hung et al. (JAMA Intern Med. 2022;182:386–395.) (Kidney International 102, 1 (2022))
• 00:00
  Assessing prognosis in IgA nephropathy - Jürgen Floege, Stephanie Wied, Thomas Rauen Kidney Int
  Assessing the prognosis is essential in chronic diseases, such as IgA nephropathy. The 2021 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend the “International IgAN Prediction Tool” (available at www.qxmd.com) for this. The key limitation was that the tool was only validated (...) (Kidney International 102, 1 (2022))
• 00:00
  Room for improvement: diagnosing and managing acute coronary syndromes in persons with reduced eGFR - Kerry L. Horne, Maarten W. Taal, Nicholas M. Selby Kidney Int
  Cardiovascular events are the leading cause of death in chronic kidney disease. A recent analysis from the High-Sensitivity Troponin in the Evaluation of Patients With Suspected Acute Coronary Syndrome trial focused on results in those with reduced estimated glomerular filtration rate. This (...) (Kidney International 102, 1 (2022))
• 00:00
  James P. Knochel, MD, 1930–2022 Kidney Int
  The editorial board of Kidney International would like to express our heartfelt condolences to the family of Dr. James Knochel, who passed away on April 13, 2022, at the age of 91. Dr. Knochel served as an Associate Editor of Kidney International from 1984–2005. Dr. Knochel had a long and (...) (Kidney International 102, 1 (2022))
• 00:00
  The proliferative and the antifibrotic side of PAX2 in tubular repair - Oliver Wessely, Stuart J. Shankland Kidney Int
  Regenerative repair following injury to proximal tubular epithelial cells (PTECs) is essential to restore the kidney to normal function in acute kidney injury. Failure to accomplish this leads to chronic kidney disease. Expression of the paired-box transcription factor Pax2 in PTECs is required (...) (Kidney International 102, 1 (2022))
• 00:00
  A link between Krüppel-like factor 4, complement activation, and kidney damage - Diana Karpman, Sebastian Loos Kidney Int
  Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound (...) (Kidney International 102, 1 (2022))
• 00:00
  Are randomized trials the best way to test different dialysis initiation regimens? - Massimo Torreggiani, Antioco Fois, Hafedh Fessi, Giorgina Barbara Piccoli Kidney Int
  We read with interest the randomized controlled trial by Vilar et al., who compared standard thrice-weekly hemodialysis (sHD) with twice weekly dialysis (iHD) in patients initiating maintenance hemodialysis (MHD).1 (Kidney International 102, 1 (2022))
• 00:00
  Acute heart failure in a kidney transplant patient - Karim Jamhour-Chelh, María Melendo-Viu, David Dobarro, Sergio Raposeiras-Roubin, Inmaculada González-Bermúdez, Alberto Ortiz Sáez, Andrés Iñiguez-Romo Kidney Int
  A 62-year-old woman with a kidney transplant was admitted with a 3-week history of shortness of breath. On examination, she was noted to have a functioning upper limb arteriovenous fistula (AVF), enlargement of her left jugular vein (Figure 1a and b), decreased basal pulmonary breath sounds, (...) (Kidney International 102, 1 (2022))
• 00:00
  Armanni-Ebstein lesion in a diabetic patient with acute tubular injury - Geetha Jagannathan, Vadim A. Finkielstein, Glen S. Markowitz, Satoru Kudose Kidney Int
  A 45-year-old White woman with recently diagnosed type 2 diabetes mellitus and hypertension presented with acute kidney injury and septic shock with gram-positive bacteremia from a toe wound. She was treated with vancomycin and piperacillin-tazobactam followed by ertapenem. She had no exposure (...) (Kidney International 102, 1 (2022))
• 00:00
  Crystal-induced colitis - Andrea Spasiano, Federica Castri, Maria Cristina Giustiniani, Maria Elena Riccioni, Alessandro Naticchia, Giuseppe Grandaliano, Nicola Panocchia Kidney Int
  A 59-year-old man undergoing dialysis was admitted to our hospital with lower limb ischemia; he had a story of long-term use of phosphate and potassium chelator. Because of anemia and repeated episodes of bowel bleeding, he underwent colonoscopy with a biopsy of the ileocecal valve and (...) (Kidney International 102, 1 (2022))
• 00:00
  The Case | Inflammatory polyarthritis in a kidney transplant recipient - Karthikeyan Manoharan, Priyansh Gupta, Hitaishi Mehta, Ritambhra Nada, Aravind Sekar, Ashwani Kumar, Aman Sharma, Manish Rathi, Harbir Singh Kohli, Keshavamurthy Vinay, Raja Ramachandran Kidney Int
  A 52-year-old man underwent live donor kidney transplantation for end-stage kidney disease in 2001 (20 years post-transplant). His maintenance immunosuppressive therapy was tacrolimus, azathioprine, and prednisolone. He had chronic allograft dysfunction (serum creatinine level of 3 mg/dl). (...) (Kidney International 102, 1 (2022))
• 00:00
  Spatially resolved transcriptomics and the kidney: many opportunities - Eryn E. Dixon, Haojia Wu, Elizabeth Sulvarán-Guel, Juanru Guo, Benjamin D. Humphreys Kidney Int
  Defining changes in gene expression during health and disease is critical for the understanding of human physiology. In recent years, single-cell/nuclei RNA sequencing (sc/snRNAseq) has revolutionized the definition and discovery of cell types and states as well as the interpretation of organ- (...) (Kidney International (2022))
• 00:00
  Indigenous Peoples’ perspectives of living with chronic kidney disease: systematic review of qualitative studies - Marianne Kerr, Nicole Evangelidis, Penelope Abbott, Jonathan C. Craig, Michelle Dickson, Nicole Scholes-Robertson, Victoria Sinka, Rahim T. Vastani, Katherine Widders, Jacqueline Stephens, Allison Tong Kidney Int
  Indigenous Peoples are defined as those who first lived in a region and have distinct cultural traditions, knowledge, and language that provide a basis for positive self-image and healthy identity.1 Indigenous Peoples have retained much of their cultural identity and displayed remarkable (...) (Kidney International (2022))

29 June

Kidney Int http://www.kidney-international.org/

• 00:00
  Podocyte-specific Nlrp3 inflammasome activation promotes diabetic kidney disease - Khurrum Shahzad, Sameen Fatima, Hamzah Khawaja, Ahmed Elwakiel, Ihsan Gadi, Saira Ambreen, Silke Zimmermann, Peter R. Mertens, Ronald Biemann, Berend Isermann Kidney Int
  Efficient therapies for diabetic kidney disease (DKD), now the leading cause of kidney failure, are lacking. One hallmark of DKD is sterile inflammation (inflammation in absence of microorganisms), but the underlying molecular mechanisms remain poorly understood. The NLRP3 inflammasome (innate (...) (Kidney International (2022))
• 00:00
  Kidney targeting of formoterol containing polymeric nanoparticles improves recovery from ischemia reperfusion-induced acute kidney injury in mice - Ernest L. Vallorz, Jaroslav Janda, Heidi M. Mansour, Rick G. Schnellmann Kidney Int
  The ?2 adrenergic receptor agonist, formoterol, is an inducer of mitochondrial biogenesis and restorer of mitochondrial and kidney function in acute and chronic models of kidney injury. Unfortunately, systemic administration of formoterol has the potential for adverse cardiovascular effects, (...) (Kidney International (2022))

27 June

Kidney Int http://www.kidney-international.org/

• 00:00
  The Dutch Childhood Cancer Survivor Study (DCCSS)-LATER 2 kidney analysis examined long-term glomerular dysfunction in childhood cancer survivors - Esmee C.M. Kooijmans, Helena J.H. van der Pal, Saskia M.F. Pluijm, Margriet van der Heiden-van der Loo, Leontien C.M. Kremer, Dorine Bresters, Eline van Dulmen-den Broeder, Marry M. van den Heuvel-Eibrink, Jacqueline J. Loonen, Marloes Louwerens, Sebastian J.C. Neggers, Cécile Ronckers, Wim J.E. Tissing, Andrica C.H. de Vries, Gertjan J.L. Kaspers, Margreet A. Veening, Arend Bökenkamp, Dutch LATER study group Kidney Int
  This investigation aimed to evaluate glomerular dysfunction among childhood cancer survivors in comparison with matched controls from the general population. In the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER 2 kidney analysis, a nationwide cross-sectional cohort study, 1024 survivors (...) (Kidney International (2022))
• 00:00
  A nationwide Dutch cohort study shows relatively good pregnancy outcomes after kidney transplantation and finds risk factors for adverse outcomes - Margriet E. Gosselink, Marleen C. van Buren, Judith Kooiman, Henk Groen, Wessel Ganzevoort, Henk W. van Hamersvelt, Olivier W.H. van der Heijden, Jacqueline van de Wetering, Titia Lely Kidney Int
  Although numbers of pregnancy after kidney transplantation (KT) are rising, high risks of adverse pregnancy outcomes (APO) remain. Though important for pre-conception counselling and pregnancy monitoring, analyses of pregnancy outcomes after KT per pre-pregnancy estimated glomerular filtration (...) (Kidney International (2022))

24 June

Kidney Int http://www.kidney-international.org/

• 00:00
  Vonoprazan-associated nephrotoxicity: extensive real-world evidence from spontaneous adverse drug reaction reports - Masayuki Ishida, Masami Tsuchiya, Junko Naito, Hitoshi Kawazoe, Daichi Watanabe, Yujiro Nonaka, Mika Sano, Hiroyasu Sakai, Akio Suzuki, Keisuke Kumada, Hiroyuki Okura, Masahito Shimizu, Hirotoshi Iihara Kidney Int
  Vonoprazan, a potassium-competitive acid blocker possessing a new mechanism of action, was first approved in Japan in 2015 for the treatment of acid-related diseases. Vonoprazan inhibits acid secretion in the cells of the gastric wall. The inhibitory effect of vonoprazan on H+,K+-ATPase is (...) (Kidney International (2022))
• 00:00
  Expression of active B-Raf proto-oncogene in kidney collecting ducts induces cyst formation in normal mice and accelerates cyst growth in mice with polycystic kidney disease - Stephen C. Parnell, Archana Raman, Yan Zhang, Emily A. Daniel, Yuqiao Dai, Aditi Khanna, Gail A. Reif, Jay L. Vivian, Timothy A. Fields, Darren P. Wallace Kidney Int
  Polycystic kidney disease (PKD) is characterized by the formation and progressive enlargement of fluid-filled cysts due to abnormal cell proliferation. Cyclic AMP agonists, including arginine vasopressin, stimulate ERK-dependent proliferation of cystic cells, but not normal kidney cells. (...) (Kidney International (2022))
• 00:00
  A tool for decision-making in kidney transplant candidates with poor prognosis to receive deceased donor transplantation in the United States - Jesse D. Schold, Anne M. Huml, Emilio D. Poggio, Peter P. Reese, Sumit Mohan Kidney Int
  The primary outcomes for kidney transplant candidates are receipt of deceased or living donor transplant, death or removal from the waiting list. Here, we conducted a retrospective analysis of national Scientific Registry of Transplant Recipients data to evaluate outcomes for 208,717 adult (...) (Kidney International (2022))

22 June

Kidney Int http://www.kidney-international.org/

• 00:00
  Results from a national-wide retrospective cohort measure the impact of C3 and soluble C5b-9 levels on kidney outcomes in C3 glomerulopathy - Sophie Chauvet, Jill J. Hauer, Florent Petitprez, Marion Rabant, Paula Vieira Martins, Véronique Baudouin, Yahsou Delmas, Noémie Jourde-Chiche, Alexandre Cez, David Ribes, Sylvie Cloarec, Aude Servais, Mohamad Zaidan, Eric Daugas, Michel Delahousse, Alain Wynckel, Amélie Ryckewaert, Anne Laure Sellier-Leclerc, Olivia Boyer, Eric Thervet, Alexandre Karras, Richard J.H. Smith, Véronique Frémeaux-Bacchi Kidney Int
  C3 glomerulopathy (C3G) is a rare complement-mediated disease. Specific treatments are not yet available and factors predictive of kidney survival such as age, kidney function and proteinuria are not specific to C3G. The prognostic value of biomarkers of complement activation, which are (...) (Kidney International (2022))
• 00:00
  Insulin-like growth factor binding protein 7 promotes acute kidney injury by alleviating poly ADP ribose polymerase 1 degradation - Ju-tao Yu, Xiao-wei Hu, Qin Yang, Run-run Shan, Yao Zhang, Ze-hui Dong, Hai-di Li, Jia-nan Wang, Chao Li, Shuai-shuai Xie, Yu-hang Dong, Wei-jian Ni, Ling Jiang, Xue-qi Liu, Biao Wei, Jia-gen Wen, Ming-ming Liu, Qi Chen, Ya-ru Yang, Gui-yang Zhang, Hong-mei Zang, Juan Jin, Yong-gui Wu, Xiang Zhong, Jun Li, Wei Wang, Xiao-ming Meng Kidney Int
  The novel biomarker, insulin-like growth factor binding protein 7 (IGFBP7), is used clinically to predict different types of acute kidney injury (AKI) and has drawn significant attention as a urinary biomarker. However, as a secreted protein in the circulation of patients with AKI, it is (...) (Kidney International (2022))
• 00:00
  Azithromycin use increases the risk of sudden cardiac death in patients with hemodialysis-dependent kidney failure - Magdalene M. Assimon, Patrick H. Pun, Lily Wang, Sana M. Al-Khatib, M. Alan Brookhart, David J. Weber, Wolfgang C. Winkelmayer, Jennifer E. Flythe Kidney Int
  Azithromycin is an antibiotic with QT-prolonging potential commonly prescribed to individuals receiving hemodialysis. Hemodialysis patients have a high prevalence of clinical conditions, such as structural heart disease, that can enhance the pro-arrhythmic effects azithromycin, but were (...) (Kidney International (2022))

20 June

Kidney Int http://www.kidney-international.org/

• 00:00
  Snapshots of nascent RNA can validate different nephron segment responses in acute kidney injury: a step toward clinically useful biomarkers? - Motonobu Nakamura, Masaomi Nangaku Kidney Int
  Acute kidney injury (AKI) is a syndrome characterized by organ damage that occurs in response to a variety of types of injury. Across a spectrum of clinical severity and pathologic damage, AKI is associated with poor prognosis. Tubular epithelial cells respond to injury and start the repair (...) (Kidney International (2022))
• 00:00
  Modelling AKI in vitro: taking organoids to the next level - Letizia De Chiara, Yun Xia Kidney Int
  Repeated episodes of acute kidney injury (AKI) can lead to chronic kidney disease (CKD). The proximal tubule (PT) is particularly vulnerable to injury because it plays a crucial metabolic role in the handling of drugs, nephrotoxins, metabolites, and signaling molecules. Despite some (...) (Kidney International (2022))

17 June

Kidney Int http://www.kidney-international.org/

• 00:00
  A retrospective cohort study predicting and validating impact of the COVID-19 pandemic in individuals with chronic kidney disease - Ashkan Dashtban, Mehrdad A. Mizani, Spiros Denaxas, Dorothea Nitsch, Jennifer Quint, Richard Corbett, Jil B. Mamza, Tamsin Morris, Mamas Mamas, Deborah A. Lawlor, Kamlesh Khunti, CVD-COVID-UK Consortium, Cathie Sudlow, Harry Hemingway, Amitava Banerjee Kidney Int
  Chronic kidney disease (CKD) is associated with increased risk of baseline mortality and severe COVID-19, but analyses across CKD stages, and comorbidities are lacking. In prevalent and incident CKD, we investigated comorbidities, baseline risk, COVID-19 incidence, and predicted versus observed (...) (Kidney International (2022))

16 June

Kidney Int http://www.kidney-international.org/

• 00:00
  Neutrophil gelatinase-associated lipocalin is elevated in children with acute kidney injury and sickle cell anemia, and predicts mortality - Anthony Batte, Sahit Menon, John M. Ssenkusu, Sarah Kiguli, Robert Kalyesubula, Joseph Lubega, Zachary Berrens, Edrisa Ibrahim Mutebi, Rodney Ogwang, Robert O. Opoka, Chandy C. John, Andrea L. Conroy Kidney Int
  Urine neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury that has been adapted to a urine dipstick test. However, there is limited data on its use in low-and-middle-income countries where diagnosis of acute kidney injury remains a challenge. To study this, (...) (Kidney International (2022))

15 June

Kidney Int http://www.kidney-international.org/

• 00:00
  A population cohort analysis of English transplant centers indicates major adverse cardiovascular events after kidney transplantation - Benjamin Anderson, Muhammad Qasim, Felicity Evison, Suzy Gallier, Jonathan N. Townend, Charles J. Ferro, Adnan Sharif Kidney Int
  Major adverse cardiovascular event (MACE) rates immediately after kidney transplantation remain uncertain due to heterogeneous reporting in the literature. To clarify this, we retrospectively studied every eligible kidney transplant procedure performed in England between April 1, 2002 and March (...) (Kidney International (2022))
• 00:00
  A novel nanoluciferase transgenic reporter measures proteinuria in zebrafish - Richard W. Naylor, Emmanuel Lemarie, Anthony Jackson-Crawford, J. Bernard Davenport, Aleksandr Mironov, Martin Lowe, Rachel Lennon Kidney Int
  The zebrafish is an important animal system for modeling human diseases. This includes kidney dysfunction as the embryonic kidney (pronephros) shares considerable molecular and morphological homology with the human nephron. A key clinical indicator of kidney disease is proteinuria, but a (...) (Kidney International (2022))
• 00:00
  Proximal-tubule molecular relay from early Protein diaphanous homolog 1 to late Rho-associated protein kinase 1 regulates kidney function in obesity-induced kidney damage - Makiko Ida-Naitoh, Hirobumi Tokuyama, Koji Futatsugi, Marie Yasuda, Keika Adachi, Takeshi Kanda, Yoshiyuki Tanabe, Shu Wakino, Hiroshi Itoh Kidney Int
  The small GTPase protein RhoA has two effectors, ROCK (Rho-associated protein kinase 1) and mDIA1 (protein diaphanous homolog 1), which cooperate reciprocally. However, temporal regulation of RhoA and its effectors in obesity-induced kidney damage remains unclear. Here, we investigated the role (...) (Kidney International (2022))
• 00:00
  Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies - Mathias Gorski, Humaira Rasheed, Alexander Teumer, Laurent F. Thomas, Sarah E. Graham, Gardar Sveinbjornsson, Thomas W. Winkler, Felix Günther, Klaus J. Stark, Jin-Fang Chai, Bamidele O. Tayo, Matthias Wuttke, Yong Li, Adrienne Tin, Tarunveer S. Ahluwalia, Johan Ärnlöv, Bjørn Olav Åsvold, Stephan J.L. Bakker, Bernhard Banas, Nisha Bansal, Mary L. Biggs, Ginevra Biino, Michael Böhnke, Eric Boerwinkle, Erwin P. Bottinger, Hermann Brenner, Ben Brumpton, Robert J. Carroll, Layal Chaker, John Chalmers, Miao-Li Chee, Miao-Ling Chee, Ching-Yu Cheng, Audrey Y. Chu, Marina Ciullo, Massimiliano Cocca, (...) Kidney Int
  Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since (...) (Kidney International (2022))

8 June

Kidney Int http://www.kidney-international.org/

• 00:00
  The Case | A pregnant female with refractory hypocalcemia - Xin Yee Tan, Mary-Beth Roberts, Leila Z. Khan, John Stewart, Xiangling Wang Kidney Int
  A 25-year-old gravida 1 parity 0 female patient at 20 weeks of gestation was found to have asymptomatic hypocalcemia during her prenatal evaluation. Despite calcium and calcitriol supplementation for 4 months, her hypocalcemia persisted. The patient had no medical or surgical history, and there (...) (Kidney International 102, 2 (2022))
• 00:00
  Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications - Maciej Tomaszewski, Andrew P. Morris, Joanna M.M. Howson, Nora Franceschini, James M. Eales, Xiaoguang Xu, Sergey Dikalov, Tomasz J. Guzik, Benjamin D. Humphreys, Stephen Harrap, Fadi J. Charchar Kidney Int
  Hypertension is a major cardiovascular disease risk factor and contributor to premature death globally. Family-based investigations confirmed a significant heritable component of blood pressure (BP), whereas genome-wide association studies revealed >1000 common and rare genetic variants (...) (Kidney International (2022))

3 June

Kidney Int http://www.kidney-international.org/

• 00:00
  Blood pressure adaptation in vertebrates: comparative biology - Akira Nishiyama, Kento Kitada, Miwa Suzuki Kidney Int
  With evolution from water to land, the osmotic regulation of body fluids and cardiovascular systems of vertebrates evolved to cope with dryness and gravity. While aquatic vertebrates can use buoyancy to compensate for the effects of gravity, terrestrial vertebrates cannot and must circulate (...) (Kidney International 102, 2 (2022))

2 June

Kidney Int http://www.kidney-international.org/

• 00:00
  Molecular mechanisms and therapeutic targets for diabetic kidney disease - Katherine R. Tuttle, Rajiv Agarwal, Charles E. Alpers, George L. Bakris, Frank C. Brosius, Peter Kolkhof, Jaime Uribarri Kidney Int
  Diabetic kidney disease has a high global disease burden and substantially increases the risk of kidney failure and cardiovascular events. Despite treatment, there is substantial residual risk of disease progression with existing therapies. Therefore, there is an urgent need to better (...) (Kidney International 102, 2 (2022))

1 June

Kidney Int http://www.kidney-international.org/

• 00:00
  Table of Contents Kidney Int
  (Kidney International 101, 6 (2022))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 101, 6 (2022))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 101, 6 (2022))
• 00:00
  In this issue Kidney Int
  In this issue of Kidney International, we are pleased to introduce a new article series called Next Generation Clinical Pathologic Conference (CPC). These articles will merge the traditional CPC with molecular medicine for a fresh approach to decipher mechanisms of kidney disease. In (...) (Kidney International 101, 6 (2022))
• 00:00
  JournalClub Kidney Int
  Rurik et al. (Science. 2022;375:91–96.) (Kidney International 101, 6 (2022))
• 00:00
  Should we consider calcimimetics as a therapeutic option for nephrotic syndrome? - Olivia Lenoir, Pierre-Louis Tharaux Kidney Int
  Calcimimetics allosterically increase the calcium ion sensitivity of the calcium-sensing receptor (CaSR). Using a CaSR knockdown in podocytes and a podocyte-specific CaSR knockout in mice, Mühlig et al. uncovered a stabilizing role for actin cytoskeleton and cell adhesion. Short-term alleviation (...) (Kidney International 101, 6 (2022))
• 00:00
  Renoprotection by GDF15 and Klotho: birds of a feather flock together - Hirotaka Komaba Kidney Int
  Growth differentiation factor 15 is a potential renoprotective factor whose expression is induced primarily at the proximal tubular site after kidney injury. Valiño-Rivas et al. confirmed the protective effect of growth differentiation factor 15 against different types of kidney injury and (...) (Kidney International 101, 6 (2022))
• 00:00
  The authors reply - Johannes F.E. Mann, Alfred K. Cheung Kidney Int
  We thank Subbiah and Bhowmik1 for their comments. They point out that the Kidney Disease: Improving Global Outcomes recommendation2 focuses on the chronic kidney disease (CKD) subgroup of Systolic Blood Pressure Intervention Trial (SPRINT). That is because it is the best available evidence for (...) (Kidney International 101, 6 (2022))
• 00:00
  KDIGO recommendations on blood pressure management in chronic kidney disease - Arunkumar Subbiah, Dipankar Bhowmik Kidney Int
  The “KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease” recommends a systolic blood pressure (BP) target (Kidney International 101, 6 (2022))
• 00:00
  Corrigendum to Fang Y, Chen B, Gong AY, et al. “The ketone body ?-hydroxybutyrate mitigates the senescence response of glomerular podocytes to diabetic insults.” Kidney Int. 2021;100:1037–1053 Kidney Int
  The above-stated article contained an incorrect version of Figure 3 in which the representative micrograph of senescence-associated beta-galactosidase (SA-?-gal) staining in the ?-hydroxybutyrate (?-HB) group in Figure 3a was inadvertently used from the results of a different experiment (...) (Kidney International 101, 6 (2022))
• 00:00
  Corrigendum to Gleeson S, Lightstone L. “BLISS-LN trial revisited: function matters.” Kidney Int. 2022;101:224–226 Kidney Int
  There are 3 corrections for the above-stated article. (Kidney International 101, 6 (2022))
• 00:00
  Acute tubulointerstitial nephritis revealing VEXAS syndrome - Charles Ronsin, Laurent Benard, Amélie Mourtada, François Perrin, Zakaria Boukerroucha Kidney Int
  A new inflammatory disease characterized by somatic X-linked mutation of the UBA1 gene has been recently described in males and named “VEXAS syndrome,” an acronym for “Vacuoles, E1 enzyme, X linked, Autoinflammatory, Somatic syndrome.”1 Despite the fact that it affects the kidneys in up to 10% of (...) (Kidney International 101, 6 (2022))
• 00:00
  Eculizumab impairs killing of Neisseria meningitidis serogroup B in atypical hemolytic uremic syndrome patients vaccinated with MenB-4C - Bryan van den Broek, Michiel van der Flier, Nicole C.A.J. van de Kar, Jack F.M. Wetzels, Marien I. de Jonge, Ronald de Groot, Kioa L. Wijnsma, Jeroen D. Langereis Kidney Int
  Recent reports suggest that eculizumab may not only compromise MenB-4C vaccination–induced serum killing of meningococci, but also opsonophagocytic killing.1,2 Using pre- and postvaccination serum from 5 patients with atypical hemolytic uremic syndrome (aHUS) on treatment with eculizumab and 2 (...) (Kidney International 101, 6 (2022))
• 00:00
  Management of refractory lupus nephritis: rationale to consider tacrolimus - Durga Prasanna Misra, Vikas Agarwal Kidney Int
  We read with great interest the review article by Mejia-Vilet et al. about the management of lupus nephritis (LN).1 The authors mentioned that few uncontrolled studies had evaluated tacrolimus in combination with mycophenolate mofetil for LN.1 In a recent prospective observational study from (...) (Kidney International 101, 6 (2022))
• 00:00
  Protective mechanisms harnessing against injurious heme and preventing kidney damage in STEC-HUS: toward new therapies? - Frank A.D.T.G. Wagener, Nicole C.A.J. van de Kar, Lambert P. van den Heuvel Kidney Int
  Hemolytic uremic syndrome can be initiated by Escherichia coli infections (Shiga-toxin–producing enterohemorrhagic Escherichia coli hemolytic uremic syndrome). When hemoglobin and heme released from ruptured erythrocytes interact with the kidney cells, this can result in platelet activation, (...) (Kidney International 101, 6 (2022))
• 00:00
  The authors reply: - Robyn G. Langham, Ekamol Tantisattamo, Kamyar Kalantar-Zadeh, Siu-Fai Lui Kidney Int
  We appreciate Meyers for sharing a real-world perspective of caring for patients with kidney diseases in developing countries. The author also provided guidance for dealing with kidney diseases of these populations as a lower priority among other public health problems, including economic (...) (Kidney International 101, 6 (2022))
• 00:00
  Kidney health literacy and public health economics - Anthony M. Meyers Kidney Int
  The authors of the special report promoting World Kidney Day must be congratulated on their article dealing with “Kidney Health for All” (the International Society of Nephrology [ISN]/International Federation of Kidney Foundations [IFKF] slogan).1 This most interesting and thought-provoking (...) (Kidney International 101, 6 (2022))
• 00:00
  Renovascular hypertension secondary to massive iliopsoas hematoma - Ryunosuke Noda, Wei Han, Yugo Shibagaki, Masahiko Yazawa Kidney Int
  An 81-year-old woman with stage G3 chronic kidney disease status post left nephrectomy for upper tract urothelial carcinoma 20 years ago was admitted to our hospital for heart failure. She acutely developed right thigh pain, and contrast-enhanced computed tomography revealed an idiopathic (...) (Kidney International 101, 6 (2022))
• 00:00
  Cerebral venous sinus thrombosis in nephrotic syndrome - Xinyi Gao, Yueming Liu, Qiang He, Xiaogang Shen Kidney Int
  A 36-year-old woman presented to the emergency department with recurrent syncope. She was diagnosed with nephrotic syndrome 16 days previously. Since she refused a kidney biopsy, she had been empirically treated with oral prednisone. A noncontrast computed tomography scan of the brain showed a (...) (Kidney International 101, 6 (2022))
• 00:00
  A shining example of discolored dialysate - Kate Drummond, Matthew Davies Kidney Int
  A 56-year-old patient on home hemodialysis noticed a yellow discoloration to the effluent fluid in his dialyzer and tubing (Figure 1a) shortly after commencing dialysis. Dialysis was ceased and a dialysate sample collected. Medical history included autosomal dominant polycystic kidney disease, (...) (Kidney International 101, 6 (2022))
• 00:00
  The Case | Late allograft dysfunction with unexpected biopsy findings - Ibrahim Batal, Heather K. Morris Kidney Int
  A 63-year-old man with end-stage kidney disease secondary to atrophic right kidney and type 2 diabetes mellitus received a living-related kidney allograft from his sister. Induction therapy included thymoglobulin, and maintenance immunosuppression consisted of tacrolimus and mycophenolate (...) (Kidney International 101, 6 (2022))

31 May

Kidney Int http://www.kidney-international.org/

• 00:00
  GSK? as a target in podocyte aging - Stuart J. Shankland, Oliver Wessely Kidney Int
  Increasing evidence highlights the importance of studying kidney aging. The global population is aging. It is estimated that by 2060 the number of Americans 65 years and older will double; similarly, 28% of Europeans will be over 65 years of age. The risk, incidence, and prevalence of chronic (...) (Kidney International (2022))

30 May

Kidney Int http://www.kidney-international.org/

• 00:00
  Caloric restriction reduces the pro-inflammatory eicosanoid 20-hydroxyeicosatetraenoic acid to protect from acute kidney injury - Karla Johanna Ruth Hoyer-Allo, Martin Richard Späth, Susanne Brodesser, Yiyi Zhu, Julia Binz-Lotter, Martin Höhne, Hella Brönneke, Katrin Bohl, Marc Johnsen, Torsten Kubacki, Katharina Kiefer, Lisa Seufert, Felix Carlo Koehler, Franziska Grundmann, Matthias J. Hackl, Bernhard Schermer, Jens Brüning, Thomas Benzing, Volker Burst, Roman-Ulrich Müller Kidney Int
  Acute kidney injury is a frequent complication in the clinical setting and associated with significant morbidity and mortality. Preconditioning with short-term caloric restriction is highly protective against kidney injury in rodent ischemia reperfusion injury models. However, the underlying (...) (Kidney International (2022))

27 May

Kidney Int http://www.kidney-international.org/

• 00:00
  Defective KIM-1 phagocytosis does not predispose to acute graft dysfunction after kidney transplantation in humans - Rita S. Suri, Ji Yun Lee, Matthew R. Ban, Bradly Shrum, Elena Tutunea-Fatan, Ola Z. Ismail, Stephen H. Leckie, Adam D. McIntyre, Qingyong Xu, Seung Ho Lee, Sonali N. de Chickera, Robert A. Hegele, Lakshman Gunaratnam Kidney Int
  Ischemia-reperfusion injury (IRI) is common to several pathologic conditions, including myocardial infarction, stroke, acute kidney injury, and delayed graft function after kidney transplantation.1 Clearance of apoptotic and necrotic cells by resident immune or epithelial cellsS1,S2 prevents (...) (Kidney International 102, 2 (2022))

26 May

Kidney Int http://www.kidney-international.org/

• 00:00
  Preemptive simultaneous pancreas kidney transplantation has survival benefit to patients - Enrique Montagud-Marrahi, Elena Cuadrado-Payán, Evelyn Hermida, Judit Cacho, David Cucchiari, Ignacio Revuelta, Jimena del Risco-Zevallos, Nuria Esforzado, Frederic Cofan, Federic Oppenheimer, Vicens Torregrosa, Joana Ferrer, Antoni J. Amor, Enric Esmatjes, Maria José Ramírez-Bajo, Mireia Musquera, Mathew Cooper, Beatriu Bayes, Josep M. Campistol, Fritz Diekmann, Pedro Ventura-Aguiar Kidney Int
  Several organ allocation protocols give priority to wait-listed simultaneous kidney-pancreas (SPK) transplant recipients to mitigate the higher cardiovascular risk of patients with diabetes mellitus on dialysis. The available information regarding the impact of preemptive simultaneous (...) (Kidney International 102, 2 (2022))
• 00:00
  Lineage tracing analysis defines erythropoietin-producing cells as a distinct subpopulation of resident fibroblasts with unique behaviors - Keiichi Kaneko, Yuki Sato, Eiichiro Uchino, Naoya Toriu, Mayo Shigeta, Hiroshi Kiyonari, Shuichiro Endo, Shingo Fukuma, Motoko Yanagita Kidney Int
  Erythropoietin (Epo) is produced by a subpopulation of resident fibroblasts in the healthy kidney. We have previously demonstrated that, during kidney fibrosis, kidney fibroblasts including Epo-producing cells transdifferentiate into myofibroblasts and lose their Epo-producing ability. However, (...) (Kidney International 102, 2 (2022))
• 00:00
  Ttc21b deficiency attenuates autosomal dominant polycystic kidney disease in a kidney tubular- and maturation-dependent manner - Wei Wang, Luciane M. Silva, Henry H. Wang, Matthew A. Kavanaugh, Tana S. Pottorf, Bailey A. Allard, Damon T. Jacobs, Rouchen Dong, Joseph T. Cornelius, Aakriti Chaturvedi, Katherine I. Swenson-Fields, Timothy A. Fields, Michele T. Pritchard, Madhulika Sharma, Chad Slawson, Darren P. Wallace, James P. Calvet, Pamela V. Tran Kidney Int
  Primary cilia are sensory organelles built and maintained by intraflagellar transport (IFT) multiprotein complexes. Deletion of several IFT-B genes attenuates polycystic kidney disease (PKD) severity in juvenile and adult autosomal dominant polycystic kidney disease (ADPKD) mouse models. (...) (Kidney International (2022))
• 00:00
  Naturally occurring stable calcium isotope ratios are a novel biomarker of bone calcium balance in chronic kidney disease - Rukshana Shroff, Alexander D. Lalayiannis, Mary Fewtrell, Claus Peter Schmitt, Aysun Bayazit, Varvara Askiti, Augustina Jankauskiene, Justine Bacchetta, Selmy Silva, Nadine Goodman, Louise McAlister, Lorenzo Biassoni, Nicola Crabtree, Anja Rahn, Dagmar-Christiane Fischer, Alexander Heuser, Ana Kolevica, Anton Eisenhauer Kidney Int
  Dysregulated calcium homeostasis is common in chronic kidney disease and causally associated with disorders of bone mineralization. However, radiological measures and biomarkers do not allow accurate evaluation of bone calcium balance. Non-radioactive calcium isotopes, 42Ca and 44Ca, are (...) (Kidney International (2022))
• 00:00
  Klotho-derived peptide 6 ameliorates diabetic kidney disease by targeting Wnt/?-catenin signaling - Xiaowen Chen, Huishi Tan, Jie Xu, Yuan Tian, Qian Yuan, Yangyang Zuo, Qiyan Chen, Xue Hong, Haiyan Fu, Fan Fan Hou, Lili Zhou, Youhua Liu Kidney Int
  Diabetic kidney disease (DKD) is one of the most common and devastating complications of diabetic mellitus, and its prevalence is rising worldwide. Klotho, an anti-aging protein, is kidney protective in DKD. However, its large size, prohibitive cost and structural complexity hamper its (...) (Kidney International (2022))

25 May

Kidney Int http://www.kidney-international.org/

• 00:00
  Bone histomorphometry for the diagnosis of renal osteodystrophy: a call for harmonization of reference ranges - Hanne Skou Jørgensen, Ana Carina Ferreira, Patrick D’Haese, Mathias Haarhaus, Marc Vervloet, Marie-Helene Lafage-Proust, Anibal Ferreira, Pieter Evenepoel, European Renal Osteodystrophy (EUROD) workgroup, Chronic Kidney Disease - Mineral and Bone Disorder Working Group (CKD-MBD WG) Kidney Int
  A bone biopsy of the anterior iliac crest is the gold standard for the evaluation of bone disease in chronic kidney disease. The bone histomorphometric analysis consists of a detailed description of bone histology, including skeletal remodeling, bone mineralization, and bone microarchitecture. (...) (Kidney International 102, 2 (2022))
• 00:00
  Diverse molecular causes of unsolved autosomal dominant tubulointerstitial kidney diseases - Florian J. Wopperer, Karl X. Knaup, Kira J. Stanzick, Karen Schneider, Tilman Jobst-Schwan, Arif B. Ekici, Steffen Uebe, Andrea Wenzel, Stefan Schliep, Carsten Schürfeld, Randolf Seitz, Wanja Bernhardt, Markus Gödel, Antje Wiesener, Bernt Popp, Klaus J. Stark, Hermann-Josef Gröne, Björn Friedrich, Martin Weiß, Nikolina Basic-Jukic, Mario Schiffer, Bernd Schröppel, Bruno Huettel, Bodo B. Beck, Genomics England Research Consortium, John A. Sayer, Christine Ziegler, Maike Büttner-Herold, Kerstin Amann, Iris M. Heid, André Reis, Francesca Pasutto, Michael S. (...) Kidney Int
  Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD) is caused by mutations in one of at least five genes and leads to kidney failure usually in mid adulthood. Throughout the literature, variable numbers of families have been reported, where no mutation can be found and therefore termed (...) (Kidney International 102, 2 (2022))
• 00:00
  Oral Coenzyme Q10 supplementation leads to better preservation of kidney function in steroid-resistant nephrotic syndrome due to primary Coenzyme Q10 deficiency - Stefania Drovandi, Beata S. Lipska-Zi?tkiewicz, Fatih Ozaltin, Francesco Emma, Bora Gulhan, Olivia Boyer, Agnes Trautmann, Hong Xu, Qian Shen, Jia Rao, Korbinian M. Riedhammer, Uwe Heemann, Julia Hoefele, Sarah L. Stenton, Alexey N. Tsygin, Kar-Hui Ng, Svitlana Fomina, Elisa Benetti, Manon Aurelle, Larisa Prikhodina, Michiel F. Schreuder, Mansoureh Tabatabaeifar, Maciej Jankowski, Sergey Baiko, Jianhua Mao, Chunyue Feng, Cuihua Liu, Shuzhen Sun, Fang Deng, Xiaowen Wang, Stéphanie Clavé, Ma?gorzata Sta?czyk, Irena Ba?asz-Chmielewska, Marc Fila, Anne M. Durkan, Tanja Kersnik Levart, Ismail (...) Kidney Int
  Primary Coenzyme Q10 (CoQ10) deficiency is an ultra-rare disorder caused by defects in genes involved in CoQ10 biosynthesis leading to multidrug-resistant nephrotic syndrome as the hallmark kidney manifestation. Promising early results have been reported anecdotally with oral CoQ10 (...) (Kidney International (2022))
• 00:00
  Daprodustat prevents cyclosporine-A mediated anemia and peritubular capillary loss - Robert Labes, Lennart Brinkmann, Vera A. Kulow, Kameliya Roegner, Susanne Mathia, Björn Balcerek, Pontus B. Persson, Christian Rosenberger, Michael Fähling Kidney Int
  Chronic Cyclosporine-A treatment is associated with serious side effects, including kidney toxicity and anemia. Although pathophysiology of Cyclosporine-A-induced kidney injury remains incompletely understood, hypoxia is likely involved. Here, we investigated the effect of the hypoxia inducible (...) (Kidney International (2022))

24 May

Kidney Int http://www.kidney-international.org/

• 00:00
  Myeloid-derived Growth Factor Deficiency Exacerbates Mitotic Catastrophe of Podocytes in Glomerular Disease - Ping Zhan, Yang Zhang, Weichen Shi, Xiaohan Liu, Zhe Qiao, Ziying Wang, Xiaojie Wang, Jichao Wu, Wei Tang, Yu Sun, Yan Zhang, Junhui Zhen, Jin Shang, Min Liu, Fan Yi Kidney Int
  Podocytes are unique, highly specialized, terminally differentiated cells, which are restricted in a post-mitotic state with limited ability to repair or regenerate. Re-entering the mitotic phase causes podocyte mitotic catastrophe, thereby leading to podocyte death and glomerular injury. (...) (Kidney International (2022))

23 May

Kidney Int http://www.kidney-international.org/

• 00:00
  Efficacy of anti–SARS-CoV-2 monoclonal antibody prophylaxis and vaccination on the Omicron variant of COVID-19 in kidney transplant recipients - Dominique Bertrand, Charlotte Laurent, Veronique Lemée, Ludivine Lebourg, Mélanie Hanoy, Frank Le Roy, Dorian Nezam, Diana Pruteanu, Steven Grange, Tristan de Nattes, Mathilde Lemoine, Sophie Candon, Dominique Guerrot Kidney Int
  Solid organ transplantation (SOT) recipients are at very high risk of developing severe coronavirus disease 2019 (COVID-19).1 Despite the implementation of a third dose of mRNA vaccine, the efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination on humoral and (...) (Kidney International 102, 2 (2022))
• 00:00
  Use of renin angiotensin aldosterone system inhibitors in children with lupus and time to glucocorticoid discontinuation - Joyce C. Chang, Pamela F. Weiss, Rui Xiao, Meredith A. Atkinson, Scott E. Wenderfer Kidney Int
  There is little data to inform use of renin angiotensin aldosterone system (RAAS) inhibitors in pediatric patients with systemic lupus erythematosus (SLE). Here, we sought to characterize RAAS inhibitor use in pediatric SLE and determine whether early RAAS inhibitor initiation among children (...) (Kidney International 102, 2 (2022))
• 00:00
  Results of untargeted analysis using the SOMAscan proteomics platform indicates novel associations of circulating proteins with risk of progression to kidney failure in diabetes - Hiroki Kobayashi, Helen C. Looker, Eiichiro Satake, Pierre Jean Saulnier, Zaipul I. Md Dom, Kristina O’Neil, Katsuhito Ihara, Bozena Krolewski, Andrzej T. Galecki, Monika A. Niewczas, Jonathan M. Wilson, Alessandro Doria, Kevin L. Duffin, Robert G. Nelson, Andrzej S. Krolewski Kidney Int
  This study applies a large proteomics panel to search for new circulating biomarkers associated with progression to kidney failure in individuals with diabetic kidney disease. Four independent cohorts encompassing 754 individuals with type 1 and type 2 diabetes and early and late diabetic (...) (Kidney International 102, 2 (2022))
• 00:00
  Pre-exposure prophylaxis with 300 mg Evusheld elicits limited neutralizing activity against the Omicron variant - Ilies Benotmane, Aurélie Velay, Gabriela Gautier-Vargas, Jérôme Olagne, Olivier Thaunat, Samira Fafi-Kremer, Sophie Caillard Kidney Int
  Immunocompromised patients show an impaired vaccine-induced immune response, resulting in an increased risk of severe coronavirus disease 2019 (COVID-19).1 In an effort to address this issue, health authorities in the US and various European countries have subsequently authorized the use of (...) (Kidney International 102, 2 (2022))

19 May

Kidney Int http://www.kidney-international.org/

• 00:00
  Bruceine A protects against diabetic kidney disease via inhibiting galectin-1 - Huiying Li, Xiaoli Zhao, Liyun Zheng, Xiukun Wang, Shuai Lin, Jiajia Shen, Hangjiang Ren, Yi Li, Qiang Qiu, Zhen Wang Kidney Int
  Bruceine A is a natural quassinoid compound extracted from the fruit of the Traditional Chinese Medicine Brucea javanica (L.) Merr. that has various types of various biological activities. However, whether the compound has a protective effect on diabetic kidney disease remains unknown. (...) (Kidney International (2022))

18 May

Kidney Int http://www.kidney-international.org/

• 00:00
  Rho-associated, coiled-coil–containing protein kinase 1 regulates development of diabetic kidney disease via modulation of fatty acid metabolism - Yosuke Nagai, Keiichiro Matoba, Yusuke Takeda, Hideji Yako, Tomoyo Akamine, Kensuke Sekiguchi, Yasushi Kanazawa, Tamotsu Yokota, Kazunori Sango, Daiji Kawanami, Kazunori Utsunomiya, Rimei Nishimura Kidney Int
  Dysregulation of fatty acid utilization is increasingly recognized as a significant component of diabetic kidney disease. Rho-associated, coiled-coil–containing protein kinase (ROCK) is activated in the diabetic kidney, and studies over the past decade have illuminated ROCK signaling as an (...) (Kidney International (2022))

14 May

Kidney Int http://www.kidney-international.org/

• 00:00
  Inferior cellular and humoral immunity against Omicron and Delta variants of concern compared with SARS-CoV-2 wild type in hemodialysis patients immunized with 4 SARS-CoV-2 vaccine doses - Moritz Anft, Arturo Blazquez-Navarro, Michael Frahnert, Lutz Fricke, Toni L. Meister, Toralf Roch, Ulrik Stervbo, Stephanie Pfaender, Timm H. Westhoff, Nina Babel Kidney Int
  With the dominance of the most recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern Omicron (B.1.1.529), the question arises, what is the reason for its high contagiousness in coronavirus disease 2019 (COVID-19)–vaccinated dialysis patients compared with the (...) (Kidney International 102, 1 (2022))

5 May

Kidney Int http://www.kidney-international.org/

• 00:00
  Biological pathways and comparison with biopsy signals and cellular origin of peripheral blood transcriptomic profiles during kidney allograft pathology - Elisabet Van Loon, Baptiste Lamarthée, Henriette de Loor, Amaryllis H. Van Craenenbroeck, Sophie Brouard, Richard Danger, Magali Giral, Jasper Callemeyn, Claire Tinel, Álvaro Cortés Calabuig, Priyanka Koshy, Ben Sprangers, Dirk Kuypers, Wilfried Gwinner, Dany Anglicheau, Pierre Marquet, Maarten Naesens Kidney Int
  Kidney transplant injury processes are associated with molecular changes in kidney tissue, primarily related to immune cell activation and infiltration. How these processes are reflected in the circulating immune cells, whose activation is targeted by strong immunosuppressants, is poorly (...) (Kidney International 102, 1 (2022))

2 May

Kidney Int http://www.kidney-international.org/

• 00:00
  Susceptibility to kidney fibrosis in mice is associated with early growth response-2 protein and tissue inhibitor of metalloproteinase-1 expression - Gábor Kökény, Ágnes Németh, Jeffrey B. Kopp, Weiping Chen, Andrew J. Oler, Anna Manzéger, László Rosivall, Miklós M. Mózes Kidney Int
  Patients with chronic kidney disease and experimental animal models of kidney fibrosis manifest diverse progression rates. Genetic susceptibility may contribute to this diversity, but the causes remain largely unknown. We have previously described kidney fibrosis with a mild or severe phenotype (...) (Kidney International 102, 2 (2022))
• 00:00
  Soluble ?-klotho and heparin modulate the pathologic cardiac actions of fibroblast growth factor 23 in chronic kidney disease - Christopher Yanucil, Dominik Kentrup, Isaac Campos, Brian Czaya, Kylie Heitman, David Westbrook, Gunars Osis, Alexander Grabner, Adam R. Wende, Julian Vallejo, Michael J. Wacker, Jose Alberto Navarro-Garcia, Gema Ruiz-Hurtado, Fuming Zhang, Yuefan Song, Robert J. Linhardt, Kenneth White, Michael S. Kapiloff, Christian Faul Kidney Int
  Fibroblast growth factor (FGF) 23 is a phosphate-regulating hormone that is elevated in patients with chronic kidney disease and associated with cardiovascular mortality. Experimental studies showed that elevated FGF23 levels induce cardiac hypertrophy by targeting cardiac myocytes via FGF (...) (Kidney International 102, 2 (2022))
• 00:00
  The characteristics of seronegative and seropositive non-hepatitis-associated cryoglobulinemic glomerulonephritis - Vincent Javaugue, Anthony M. Valeri, Insara Jaffer Sathick, Samar M. Said, Sibel Erdogan Damgard, David L. Murray, Tyler Klobucher, Nicole K. Andeen, Sanjeev Sethi, Fernando C. Fervenza, Nelson Leung, Samih H. Nasr Kidney Int
  The clinicopathologic characteristics and long-term outcome of non-hepatitis-associated cryoglobulinemic glomerulonephritis (CryoGN) are not well-defined and cases with undetectable serum cryoglobulin (seronegative CryoGN) have not been investigated.To resolve this, we retrospectively (...) (Kidney International 102, 2 (2022))
• 00:00
  Clinicopathological characteristics of high-altitude polycythemia-related kidney disease in Tibetan inhabitants - Hui Wang, Chen Tang, Zonghui Dang, A Yong, Lijun Liu, Suxia Wang, Minghui Zhao Kidney Int
  High-altitude polycythemia (HAPC) is a clinical syndrome that occurs in native inhabitants or long-term residents living at altitude. The kidney is one of the most affected organs. However, the clinical and kidney histopathological profiles of HAPC-related kidney disease have rarely been (...) (Kidney International 102, 1 (2022))

1 May

Kidney Int http://www.kidney-international.org/

• 00:00
  A challenge to the kidney community by a man-made crisis - P. Toby Coates, Germaine Wong, Brad H. Rovin, Pierre Ronco, Entire Editorial and Management Team Kidney Int
  “No man is an island,Entire of itself,Each is a part of the continent,A part of the main,If a clod be washed away by sea,Europe is the less,As well as if a promontory were”John Donne, For Whom the Bell Tolls, 1572–1631 (Kidney International 101, 5 (2022))
• 00:00
  Table of Contents Kidney Int
  (Kidney International 101, 5 (2022))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 101, 5 (2022))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 101, 5 (2022))
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  In This Issue Kidney Int
  Anti–brush border antibody disease (ABBA) is a rare, progressive kidney disease that has, until now, been characterized only by autoantibodies against megalin. Morelle et al. identified a patient with ABBA by histology, but without anti-megalin antibodies. Using proteomics to identify the (...) (Kidney International 101, 5 (2022))
• 00:00
  Journal Club Kidney Int
  Wu et al. (J Clin Invest. 2021;131:e136329.) (Kidney International 101, 5 (2022))
• 00:00
  Tribute to Jan Weening (1950–2022) - John H. Dirks, Sandrine Florquin, Pierre Ronco Kidney Int
  Jan J. Weening, Professor of Pathology, University of Amsterdam, died of a sudden cerebral hemorrhage on January 31, 2022, at his home in Hilversum, the Netherlands—he was just 3 months short of the age of 72 years. He was a former President of the International Society of Nephrology (ISN) and a (...) (Kidney International 101, 5 (2022))
• 00:00
  The authors reply: - Lena Berchtold, Sophie de Seigneux, Jean-Paul Vallée Kidney Int
  We appreciate the interest of Inoue et al. in our article exploring the use of diffusion-magnetic resonance imaging to predict the decline of kidney function in chronic kidney disease and in patients with a kidney allograft.1 (Kidney International 101, 5 (2022))
• 00:00
  In memoriam: Charles van Ypersele de Strihou (1933–2021) - Yves Pirson, Olivier Devuyst Kidney Int
  Charles van Ypersele de Strihou, a precursor and early leader of European nephrology, died peacefully at home on Tuesday, December 7, 2021, at the age of 88 years. He was Professor Emeritus of Nephrology at the Catholic University of Louvain Medical School in Brussels, Belgium. van Ypersele was (...) (Kidney International 101, 5 (2022))
• 00:00
  Regulation of T- and B-cell interactions determines the clinical phenotype associated with donor-specific antibodies - Sumoyee Basu, Anthony Dorling Kidney Int
  The cellular mechanisms that regulate donor-specific antibody formation and antibody-mediated rejection remain unknown. In this issue, Louis et al. report that specific T-regulatory cell and B-regulatory transitional cell subsets are concomitantly diminished in patients with donor-specific (...) (Kidney International 101, 5 (2022))
• 00:00
  The authors reply: - Verônica T. Costa e Silva, Lesley A. Inker, Emmanuel A. Burdmann, Andrew S. Levey Kidney Int
  As described in their letter, Iversen et al.1 assessed the performance of equations for estimated glomerular filtration rate (eGFR) using serum creatinine (eGFRcr), serum cystatin C (eGFRcys), or both (eGFRcr-cys) in 110 older medical Danish patients in the emergency department compared to (...) (Kidney International 101, 5 (2022))
• 00:00
  Performance of the Cockcroft-Gault, Modification of Diet in Renal Disease, and new Chronic Kidney Disease Epidemiology Collaboration equations without race in older acute medical patients - Esben Iversen, Anne Kathrine Bengaard, Aino Andersen, Thomas Kallemose, Morten Damgaard, Mads Hornum, Bo Feldt-Rasmussen, Ove Andersen, Morten Baltzer Houlind Kidney Int
  Costa e Silva et al. compare the performance of equations for estimated glomerular filtration rate (GFR) in patients with cancer and conclude that the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations should be preferred over the Cockcroft-Gault equation.1 We have previously (...) (Kidney International 101, 5 (2022))
• 00:00
  The relationship between imaging features of diffusion-weighted imaging and prognosis of chronic kidney disease - Tsutomu Inoue, Eito Kozawa, Masahiro Ishikawa, Naoki Kobayashi, Hirokazu Okada Kidney Int
  Berchtold et al. reported that corticomedullary differentiation (CMD) abnormality in the apparent diffusion coefficient (ADC) for diffusion-weighted magnetic resonance (MR) imaging affords an index that is significantly correlated with prognosis in chronic kidney disease.1 We express our (...) (Kidney International 101, 5 (2022))
• 00:00
  Metformin versus SGLT-2 inhibitors: how low can we go? - Menno Pruijm, Olivier Phan, Anne Zanchi Kidney Int
  The progression of chronic kidney disease is difficult to stop once established. Metformin and sodium-glucose cotransporter 2 inhibitors show promise, but clinical trials with a head-to-head comparison in patients with more advanced (stage 3b–4) chronic kidney disease are largely lacking, partly (...) (Kidney International 101, 5 (2022))
• 00:00
  Virus-related collapsing glomerulopathy, a common mechanism of injury? - Joseph P. Gaut Kidney Int
  Collapsing glomerulopathy frequently shows focal lesions on biopsy, creating challenges with transcriptomic investigations because of inadequate tissue sample. This challenge is overcome with spatial transcriptomics, technology linking transcriptomic data to histology. Applying this technology (...) (Kidney International 101, 5 (2022))
• 00:00
  Mitochondrial pharmacotherapy during pregnancy and lactation in an ADPKD mouse model: a win for both mothers and their offspring - Wei Wang, Pamela V. Tran Kidney Int
  Pharmacotherapies that are safe during pregnancy are lacking for patients with autosomal dominant polycystic kidney disease. In this issue, Daneshgar et al. reveal that administration of the mitochondrial-protective peptide, elamipretide, during pregnancy and lactation in a mouse model with (...) (Kidney International 101, 5 (2022))
• 00:00
  The authors reply: - Frank Bridoux, Nelson Leung, Jean Paul Fermand Kidney Int
  We read with interest the letter by Shulman et al.1 questioning our recommendation on the use of pamidronate over zoledronic acid (ZA) in patients with myeloma light chain cast nephropathy.2 (Kidney International 101, 5 (2022))
• 00:00
  Pamidronate versus zoledronic acid for the treatment of multiple myeloma–related hypercalcemia - Rachel Shulman, Abdallah S. Geara, Jeffrey S. Berns Kidney Int
  The recent review by Bridoux et al.,1 in Kidney International, on the management of acute kidney injury in multiple myeloma states that pamidronate is preferred to zoledronic acid (ZA) for treating hypercalcemia in multiple myeloma due to lower risk of kidney complications. We do not believe (...) (Kidney International 101, 5 (2022))
• 00:00
  Lay A TRAP for myeloid cell response in diabetic kidney disease - Hiroshi Nishi Kidney Int
  The functions of the renin-angiotensin system are crucial in the progression of diabetic kidney disease. ATRAP is a type 1 angiotensin II receptor–associated protein that negatively regulates intracellular angiotensin II signaling. In this issue, Haruhara et al. revealed that ATRAP deficiency of (...) (Kidney International 101, 5 (2022))
• 00:00
  The authors reply: - Raphael J. Rosen, Hilda E. Fernandez, Shayan Shirazian, Andrew A. Moses Kidney Int
  Yang et al.1 assert that medial calcification in the subcutaneous arterioles is the gold standard for diagnosis of calciphylaxis. These arterioles are typically 40–600 ?m, and the smallest resolution that the linear array transducer (the probe with the best spatial resolution that is in regular (...) (Kidney International 101, 5 (2022))
• 00:00
  Comments on “Ultrasound findings of calciphylaxis” - Canlin Yang, Xiaoliang Zhang, Xiaotong Xie, Yu Zhao Kidney Int
  A recently published nephrology image uses noninvasive ultrasound to diagnose calciphylaxis,1 which is a valuable attempt. However, considering the specificity of the diagnosis of calciphylaxis and the complexity of its comorbidities, we think there are several controversies in this (...) (Kidney International 101, 5 (2022))
• 00:00
  The authors reply: - Pan Yu, Raymond C. Harris, Ming-Zhi Zhang Kidney Int
  We appreciate Professor Cravedi’s interest1 in our recent study2 and the helpful suggestions for our future research. CD11b+Ly6clow monocytes, also known as nonclassical monocytes or patrolling monocytes, have received considerable attention in recent years because they may be associated with (...) (Kidney International 101, 5 (2022))
• 00:00
  Role of cyclooxygenase-2 in macrophage subsets during kidney repair - Paolo Cravedi Kidney Int
  We congratulate Pan et al. for their beautiful study published in Kidney International.1 The work indicates that the cyclooxygenase-2 pathway in myeloid cells is a critical mediator of the balance between tissue injury and repair following acute kidney injury (AKI). The elegantly designed (...) (Kidney International 101, 5 (2022))
• 00:00
  Pouch of Douglas hernia in a patient on peritoneal dialysis - Meng-qin Zhang, Xiao-yu Jia, Zhi-kai Yang, Tian-tian Ma, Yu-feng Xu, Ye Lu, Jie Dong Kidney Int
  A 59-year-old woman on continuous ambulatory peritoneal dialysis presented to our center with the complaint of her swollen hip and intermittent vaginal discharge for 2 years. She developed those symptoms after a sudden heave and long squat. These symptoms became worse when she stood or walked (...) (Kidney International 101, 5 (2022))
• 00:00
  Doxorubicin-associated red-colored dialysate - Chia-Ling Helen Wei, Ding-Jie Lee, Chia-Chao Wu Kidney Int
  A 46-year-old woman with a history of hypertensive cardiovascular disease and end-stage kidney disease on continuous ambulatory peritoneal dialysis for 8 years was first evaluated for red-colored dialysate. Her recent history included an incidentally discovered mass in her left lower abdomen (...) (Kidney International 101, 5 (2022))
• 00:00
  Rapid regression of uremic calcinosis - Tomasz Ho?ub, Marta Jagodzi?ska, Agnieszka Makówka, Kamila K?dzierska, Micha? Nowicki Kidney Int
  A 28-year-old man with end-stage kidney disease from posterior urethral valve undergoing peritoneal dialysis for 3.5 years, presented with pain and swelling of both shoulders. Computed tomography revealed numerous massive calcifications in the subcutaneous tissue around both shoulder joints (...) (Kidney International 101, 5 (2022))
• 00:00
  The Case | A rare donor-derived cause of delayed graft function - Himabindu Yerneni, Miroslav Sekulic, Praveen Gundelly, Nagaraju Sarabu Kidney Int
  A 52-year-old African American man presented to the office with abdominal pain over his kidney allograft and ongoing anuria, 1 week after a deceased donor transplant. He was discharged from hospital 2 days before presentation. His medical history was notable for end-stage kidney disease (...) (Kidney International 101, 5 (2022))

28 April

Kidney Int http://www.kidney-international.org/

• 00:00
  Application of the International IgA Nephropathy Prediction Tool one or two years post-biopsy - Sean J. Barbour, Rosanna Coppo, Hong Zhang, Zhi-Hong Liu, Yusuke Suzuki, Keiichi Matsuzaki, Lee Er, Heather N. Reich, Jonathan Barratt, Daniel C. Cattran, International IgA Nephropathy Network Kidney Int
  The International IgA Nephropathy (IgAN) Prediction Tool is the preferred method in the 2021 KDIGO guidelines to predict, at the time of kidney biopsy, the risk of a 50% drop in estimated glomerular filtration rate or kidney failure. However, it is not known if the Prediction Tool can be (...) (Kidney International 102, 1 (2022))

25 April

Kidney Int http://www.kidney-international.org/

• 00:00
  The phenotype of HLA-binding B cells from sensitized kidney transplant recipients correlates with clinically prognostic patterns of interferon-? production against purified HLA proteins - Hannah Burton, Laura McLaughlin, Kin Yee Shiu, Olivia Shaw, Nizam Mamode, Jo Spencer, Anthony Dorling Kidney Int
  B cells play crucial roles in cell-mediated alloimmune responses. In vitro, B cells can support or regulate indirect T-cell alloreactivity in response to donor antigens on ELISpot and these patterns associate with clinical outcome. Previous reports of associations between B-cell phenotype and (...) (Kidney International 102, 2 (2022))
• 00:00
  Protein phosphatase 2Ac? modulates fatty acid oxidation and glycolysis to determine tubular cell fate and kidney injury - Mengru Gu, Mengzhu Tan, Lu Zhou, Xiaoli Sun, Qingmiao Lu, Mingjie Wang, Hanlu Jiang, Yan Liang, Qing Hou, Xian Xue, Zhuo Xu, Chunsun Dai Kidney Int
  Energy metabolism is crucial in maintaining cellular homeostasis and adapting to stimuli for tubular cells. However, the underlying mechanisms remain largely unknown. Here, we report that PP2Ac? was upregulated in damaged tubular cells from patients and animal models with acute or chronic kidney (...) (Kidney International 102, 2 (2022))
• 00:00
  Current kidney function parameters overestimate kidney tissue repair in reversible experimental kidney disease - Barbara Mara Klinkhammer, Simone Buchtler, Sonja Djudjaj, Nassim Bouteldja, Runolfur Palsson, Vidar Orn Edvardsson, Margret Thorsteinsdottir, Jürgen Floege, Matthias Mack, Peter Boor Kidney Int
  Although underlying mechanisms and the clinical course of kidney disease progression are well described, less is known about potential disease reversibility. Therefore, to analyze kidney recovery, we adapted a commonly used murine chronic kidney disease (CKD) model of 2,8- dihydroxyadenine (...) (Kidney International 102, 2 (2022))
• 00:00
  Blocking ribosomal protein S6 phosphorylation inhibits podocyte hypertrophy and focal segmental glomerulosclerosis - Fang Li, Yili Fang, Qiyuan Zhuang, Meichu Cheng, Desmond Moronge, Hao Jue, Oded Meyuhas, Xiaoqiang Ding, Zhigang Zhang, Jian-Kang Chen, Huijuan Wu Kidney Int
  Ribosomal protein S6 (rpS6) phosphorylation mediates the hypertrophic growth of kidney proximal tubule cells. However, the role of rpS6 phosphorylation in podocyte hypertrophy and podocyte loss during the pathogenesis of focal segmental glomerulosclerosis (FSGS) remains undefined. Here, we (...) (Kidney International 102, 1 (2022))
• 00:00
  A novel unbiased method reveals progressive podocyte globotriaosylceramide accumulation and loss with age in females with Fabry disease - Behzad Najafian, Aurelio Silvestroni, Alexey Sokolovskiy, Camilla Tøndel, Einar Svarstad, Bogdan Obrisca, Gener Ismail, Myrl D. Holida, Michael Mauer Kidney Int
  While females can suffer serious complications of Fabry disease, most studies are limited to males to avoid confounding by mosaicism. Here, we developed a novel unbiased method for quantifying globotriaosylceramide (GL3) inclusion volume in affected podocytes (F+) in females with Fabry disease (...) (Kidney International 102, 1 (2022))
• 00:00
  Cyclin-dependent kinase 4-related tubular epithelial cell proliferation is regulated by Paired box gene 2 in kidney ischemia-reperfusion injury - Keisuke Sako, Kengo Furuichi, Shohei Makiishi, Yuta Yamamura, Toshiya Okumura, Hong Thu Le, Shinji Kitajima, Tadashi Toyama, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Miho Shimizu, Fumio Niimura, Taiji Matsusaka, Shuichi Kaneko, Takashi Wada Kidney Int
  Paired box 2 (Pax2) is a transcription factor essential for kidney development and is reactivated in proximal tubular epithelial cells (PTECs) during recovery from kidney injury. However, the role of Pax2 in this process is still unknown. Here the role of Pax2 reactivation during injury was (...) (Kidney International 102, 1 (2022))
• 00:00
  Variation of the clinical spectrum and genotype-phenotype associations in Coenzyme Q10 deficiency associated glomerulopathy - Stefania Drovandi, Beata S. Lipska-Zi?tkiewicz, Fatih Ozaltin, Francesco Emma, Bora Gulhan, Olivia Boyer, Agnes Trautmann, Szymon Zi?tkiewicz, Hong Xu, Qian Shen, Jia Rao, Korbinian M. Riedhammer, Uwe Heemann, Julia Hoefele, Sarah L. Stenton, Alexey N. Tsygin, Kar-Hui Ng, Svitlana Fomina, Elisa Benetti, Manon Aurelle, Larisa Prikhodina, Anne M. Schijvens, Mansoureh Tabatabaeifar, Maciej Jankowski, Sergey Baiko, Jianhua Mao, Chunyue Feng, Fang Deng, Caroline Rousset-Rouviere, Ma?gorzata Sta?czyk, Irena Ba?asz-Chmielewska, Marc Fila, Anne M. Durkan, Tanja Kersnik Levart, Ismail Dursun, (...) Kidney Int
  Primary Coenzyme Q10 deficiency is a rare mitochondriopathy with a wide spectrum of organ involvement, including steroid-resistant nephrotic syndrome mainly associated with disease-causing variants in the genes COQ2, COQ6 or COQ8B. We performed a systematic literature review, PodoNet, mitoNET, (...) (Kidney International (2022))
• 00:00
  Endothelial-specific loss of Krüppel-Like Factor 4 triggers complement-mediated endothelial injury - Chelsea C. Estrada, Stephanie Cardona, Yiqing Guo, Monica P. Revelo, Vivette D. D’Agati, Siva Koganti, Jason Devaraj, John C. He, Peter S. Heeger, Sandeep K. Mallipattu Kidney Int
  Thrombotic microangiopathy (TMA) in the kidney represents the most severe manifestation of kidney microvascular endothelial injury. Despite the source of the inciting event, the diverse clinical forms of kidney TMA share dysregulation of endothelial cell transcripts and complement activation. (...) (Kidney International 102, 1 (2022))

22 April

Kidney Int http://www.kidney-international.org/

• 00:00
  Reticulon-1A mediates diabetic kidney disease progression through endoplasmic reticulum-mitochondrial contacts in tubular epithelial cells - Yifan Xie, Jing E, Hong Cai, Fang Zhong, Wenzhen Xiao, Ronald E. Gordon, Lois Wang, Ya-Li Zheng, Aihua Zhang, Kyung Lee, John Cijiang He Kidney Int
  Recent epidemiological studies suggest that some patients with diabetes progress to kidney failure without significant albuminuria and glomerular injury, suggesting a critical role of kidney tubular epithelial cell (TEC) injury in diabetic kidney disease (DKD) progression. However, the major (...) (Kidney International 102, 2 (2022))

20 April

Kidney Int http://www.kidney-international.org/

• 00:00
  Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference - KDIGO Conference Participants Kidney Int
  Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as well as genes for complex kidney diseases that manifest in combination with environmental factors, have been discovered. Genetic findings are increasingly used to inform clinical management of nephropathies, (...) (Kidney International 101, 6 (2022))

13 April

Kidney Int http://www.kidney-international.org/

• 00:00
  The impact of genetic background on mouse models of kidney disease - Rei Bufi, Ron Korstanje Kidney Int
  The mouse is the most commonly used mammalian model to study disease, including kidney disease. However, close attention needs to be paid to the differences and effects of genetic background. The default choice of most investigators is to use C57BL/6 mice, but not all C57BL/6 mice are the same. (...) (Kidney International 102, 1 (2022))
• 00:00
  Suboptimal antibody response against SARS-CoV-2 Omicron variant after third dose of mRNA vaccine in kidney transplant recipients - Ayman Al Jurdi, Rodrigo B. Gassen, Thiago J. Borges, Isadora T. Lape, Leela Morena, Orhan Efe, Zhabiz Solhjou, Rania El Fekih, Christa Deban, Brigid Bohan, Vikram Pattanayak, Camille N. Kotton, Jamil R. Azzi, Leonardo V. Riella Kidney Int
  Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in >5 million deaths worldwide,1 with the Delta (B.1.617.2) and, more recently, the Omicron (B.1.1.529) variants accounting for most cases.2 Kidney transplant recipients (...) (Kidney International 101, 6 (2022))

11 April

Kidney Int http://www.kidney-international.org/

• 00:00
  Humoral response after a fourth “booster” dose of a Coronavirus disease 2019 vaccine following a 3-dose regimen of mRNA-based vaccination in dialysis patients - Pierre Housset, Sabah Kubab, Latifa Hanafi, Agathe Pardon, Nathalie Vittoz, Dogan-Firat Bozman, Valérie Caudwell, Anne-Laure Faucon Kidney Int
  Despite an initial satisfactory increase in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antispike antibody (Ab) titer after completing a 3-dose regimen in the first set of vaccination in dialysis patients,1 Ab titer substantially decreases at 6 months in this population.2 Other (...) (Kidney International 101, 6 (2022))
• 00:00
  Early treatment with sotrovimab monoclonal antibody in kidney transplant recipients with Omicron infection - Nathalie Chavarot, Clea Melenotte, Lucile Amrouche, Claire Rouzaud, Rebecca Sberro-Soussan, Juliette Pavie, Frank Martinez, Anne Pouvaret, Marianne Leruez-Ville, Delphine Cantin, Jacques Fourgeaud, Claire Delage, Damien Vimpere, Marie Noëlle Peraldi, Christophe Legendre, Fanny Lanternier, Julien Zuber, Anne Scemla, Dany Anglicheau Kidney Int
  Early data about coronavirus disease 2019 (COVID-19) related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant (B.1.1.529) suggest that it may be less severe than prior variants of concern in the general population.1–3 However, our preliminary data (NC, personal (...) (Kidney International 101, 6 (2022))

9 April

Kidney Int http://www.kidney-international.org/

• 00:00
  TCR??+ CD4?/CD8– “double negative” T cells in health and disease—implications for the kidney - Andrea M. Newman-Rivera, Johanna T. Kurzhagen, Hamid Rabb Kidney Int
  Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor ?? but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells (...) (Kidney International 102, 1 (2022))

7 April

Kidney Int http://www.kidney-international.org/

• 00:00
  Calculated versus measured albumin-creatinine ratio to predict kidney failure and death in people with chronic kidney disease - Huda Al-Wahsh, Ngan N. Lam, Robert R. Quinn, Paul E. Ronksley, Manish M. Sood, Brenda Hemmelgarn, Navdeep Tangri, Thomas Ferguson, Marcello Tonelli, Pietro Ravani, Ping Liu Kidney Int
  Albumin-to-creatinine ratio (ACR), the preferred method to quantify proteinuria, can be calculated from urine dipstick protein or protein-to-creatinine ratio (PCR). The performance of calculated vs. measured ACR in predicting kidney failure and death without kidney failure in people with (...) (Kidney International 101, 6 (2022))
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  Harmonization of epidemiology of acute kidney injury and acute kidney disease produces comparable findings across four geographic populations - Simon Sawhney, Samira Bell, Corri Black, Christian Fynbo Christiansen, Uffe Heide-Jørgensen, Simon Kok Jensen, Paul E. Ronksley, Zhi Tan, Marcello Tonelli, Heather Walker, Matthew T. James Kidney Int
  There is substantial variability in the reported incidence and outcomes of acute kidney injury (AKI). The extent to which this is attributable to differences in source populations versus methodological differences between studies is uncertain. We used 4 population-based datasets from Canada, (...) (Kidney International 101, 6 (2022))

1 April

Kidney Int http://www.kidney-international.org/

• 00:00
  Anti-aging mechanism of calorie restriction in humans - Sho Hasegawa, Masaomi Nangaku Kidney Int
  Animal studies have demonstrated that calorie restriction lowers the incidence of age-related diseases and leads to longer lifespans.1 However, a question that has not been answered is whether long-term calorie restriction has similar beneficial effects in humans. A recent study by Spadaro et (...) (Kidney International 102, 2 (2022))
• 00:00
  Tubular cell plasticity—new hope for autosomal dominant polycystic kidney disease? - Marine Berquez, Olivier Devuyst Kidney Int
  Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of chronic kidney disease. Typical forms of ADPKD are caused by mutations in either PKD1 or PKD2, encoding polycystin (PC)-1 and PC2, respectively. The polycystins are expressed in various membrane domains, (...) (Kidney International 102, 1 (2022))
• 00:00
  Table of Contents Kidney Int
  (Kidney International 101, 4 (2022))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 101, 4 (2022))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 101, 4 (2022))
• 00:00
  Journal Club Kidney Int
  Reindl-Schwaighofer et al. (JAMA Intern Med. 2022;182:165–171.) (Kidney International 101, 4 (2022))
• 00:00
  In This Issue Kidney Int
  Zambrano et al. used single-cell RNA sequencing of glomerular cells from ddY-IgA nephropathy (IgAN) prone mice to study the molecular changes occurring in the kidneys after mesangial IgA deposition, but before structural alterations occur in the kidneys. They found early activation of (...) (Kidney International 101, 4 (2022))
• 00:00
  Semaphorin class 3C, vascular permeability, and the swollen injured kidney - Christian Rosenberger Kidney Int
  Class 3 semaphorins (SEMA3) are secreted glycoproteins with established roles in the developing brain, heart, and kidney. In this issue of Kidney International, Cai et al. show that in acutely injured kidneys, semaphorin isoform SEMA3C is expressed de novo in glomeruli and the nephron, secreted (...) (Kidney International 101, 4 (2022))
• 00:00
  The ins and outs of ferric citrate - Volker H. Haase Kidney Int
  Ferric citrate is used clinically for the treatment of hyperphosphatemia in patients with chronic kidney disease and is approved as an oral iron replacement product for patients with iron-deficiency anemia. In this issue of Kidney International, Hanudel and colleagues take advantage of genetic (...) (Kidney International 101, 4 (2022))
• 00:00
  Donor-derived cell-free DNA in kidney transplantation: evolving concepts and potential limitations - Edmund Huang, Stanley C. Jordan Kidney Int
  Bu et al. report that elevated donor-derived cell-free DNA detected on serial measurements performed for both surveillance and assessment of kidney allograft dysfunction was associated with rejection, future de novo donor-specific antibodies, and decline in estimated glomerular filtration rate. (...) (Kidney International 101, 4 (2022))
• 00:00
  Hypertrophy and glomerular cell adaptation through crosstalk leads to glomerular injury after kidney transplantation - Emelie Lassen, Ilse S. Daehn Kidney Int
  Menon et al. report cell-specific transcriptional changes in podocytes and glomerular endothelial cells that indicate cell stress and increased bidirectional crosstalk among these cells in apparently healthy human allografts. They identified common and independent podocytes and glomerular (...) (Kidney International 101, 4 (2022))
• 00:00
  Multi-omics studies reveal genes critical for AKI and ferroptosis - Midori Sakashita, Masaomi Nangaku Kidney Int
  Family-based linkage studies, more recently combined with exome sequencing, have identified coding regions that explain the development of cystic kidney diseases and nephrotic syndrome, as well as other rare kidney diseases; however, common adult-onset kidney diseases, including hypertensive (...) (Kidney International 101, 4 (2022))
• 00:00
  Absent abdominal musculature in a girl - Detlef Bockenhauer, Imran Mushtaq, Francesca Faravelli Kidney Int
  A 6-month-old girl was referred for further management of her congenital malformations. These were identified antenatally, and, at birth, she was noted to have wrinkled abdominal skin (Figure 1) consistent with the syndrome of absent abdominal musculature (Eagle-Barrett syndrome). The typical (...) (Kidney International 101, 4 (2022))
• 00:00
  The Case | A 17-year-old boy with growth failure and chronic kidney disease - Santhi N. Logel, Ellen L. Connor, Neil J. Paloian Kidney Int
  A 17-year-old boy with no previous medical history presented for evaluation of a left axillary mass. A review of systems was positive for eyelid, hand, and feet edema. He was normotensive. On physical examination, there was a 0.5-cm nonmobile, nontender mass in the left axilla. Laboratory (...) (Kidney International 101, 4 (2022))
• 00:00
  Recurrent hyperparathyroidism presenting as spinal cord compression - Melanie L. Wyld, Labib Rahman, Hayley Collins, Thiveya Theivendran, Angela Bayly, Gopala K. Rangan Kidney Int
  A 32-year-old man with end-stage kidney disease due to IgA nephropathy, on hemodialysis for 6 years, presented with 1 month of severe right hip and upper thigh pain. Twelve months previously, a subtotal parathyroidectomy had been performed. To investigate the cause of his pain, a lower limb (...) (Kidney International 101, 4 (2022))
• 00:00
  Polycystic horseshoe kidney - Madison S. Hill, Michael W. Phelan Kidney Int
  A 57-year-old man presented for a living unrelated kidney transplant. His end-stage kidney disease was secondary to autosomal dominant polycystic kidney disease, and he was coincidentally noted to have a horseshoe kidney on abdominal imaging (Figure 1). He had been maintained on hemodialysis (...) (Kidney International 101, 4 (2022))

30 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Immunoaging within the kidney via injury-associated tertiary lymphoid tissue - A. Richard Kitching Kidney Int
  Past immunologic dogma positioned secondary lymphoid organs—primarily the lymph nodes and the spleen—as the sites where adaptive immune responses were initiated and perpetuated. Solid organs, such as the kidney, were viewed largely as tissues to which cells of the immune system were recruited. (...) (Kidney International 102, 1 (2022))

26 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Effects of acid on bone - David A. Bushinsky, Nancy S. Krieger Kidney Int
  The homeostatic regulation of a stable systemic pH is of critical importance for mammalian survival. During metabolic acidosis (a reduction in systemic pH caused by a primary decrease in serum bicarbonate concentration), as seen in clinical disorders such as the later stages of chronic kidney (...) (Kidney International 101, 6 (2022))

24 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis - Dong Zhou, Yuanyuan Wang, Yuan Gui, Haiyan Fu, Shanshan Zhou, Yanlin Wang, Sheldon I. Bastacky, Donna B. Stolz, Youhua Liu Kidney Int
  Activation of canonical Wnt signaling has been implicated in podocyte injury and proteinuria. As Wnts are secreted proteins, whether Wnts derived from podocytes are obligatory for promoting proteinuria remains unknown. To address this, we generated conditional knockout mice where Wntless, a (...) (Kidney International 102, 1 (2022))
• 00:00
  Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency - Nan Guan, Hanako Kobayashi, Ken Ishii, Olena Davidoff, Feng Sha, Talat A. Ikizler, Chuan-Ming Hao, Navdeep S. Chandel, Volker H. Haase Kidney Int
  Oxidative metabolism in mitochondria regulates cellular differentiation and gene expression through intermediary metabolites and reactive oxygen species. Its role in kidney development and pathogenesis is not completely understood. Here we inactivated ubiquinone-binding protein QPC, a subunit (...) (Kidney International 102, 1 (2022))

23 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation - Rajasree Menon, Andrew S. Bomback, Blue B. Lake, Christy Stutzke, Stephanie M. Grewenow, Steven Menez, Vivette D. D’Agati, Sanjay Jain, Kidney Precision Medicine Project Kidney Int
  Acute kidney injury (AKI) induces a broad range of clinically significant perturbations in kidney morphology and function. Insights into the molecular and cellular basis governing a clinical-pathologic course are limited by the availability of molecular maps of healthy and injured kidney cells. (...) (Kidney International 101, 6 (2022))
• 00:00
  Type I interferon–related kidney disorders - Lorenzo Lodi, Maria V. Mastrolia, Federica Bello, Giovanni M. Rossi, Maria L. Angelotti, Yanick J. Crow, Paola Romagnani, Augusto Vaglio Kidney Int
  Type I interferon (IFN-I) mediates tissue damage in a wide range of kidney disorders, directly affecting the biology and function of several renal cell types including podocytes, mesangial, endothelial, and parietal epithelial cells. Enhanced IFN-I signaling is observed in the context of viral (...) (Kidney International 101, 6 (2022))

22 March

Kidney Int http://www.kidney-international.org/

• 00:00
  The sexual dimorphism of kidney growth in mice and humans - Denise Laouari, Paul Vergnaud, Takuo Hirose, Mohamad Zaidan, Marion Rabant, Clément Nguyen, Martine Burtin, Christophe Legendre, Patrice Codogno, Gerard Friedlander, Dany Anglicheau, Fabiola Terzi Kidney Int
  Kidney mass and function are sexually determined, but the cellular events and the molecular mechanisms involved in this dimorphism are poorly characterized. By combining female and male mice with castration/replacement experiments, we showed that male mice exhibited kidney overgrowth from five (...) (Kidney International 102, 1 (2022))
• 00:00
  Growth differentiation factor-15 preserves Klotho expression in acute kidney injury and kidney fibrosis - Lara Valiño-Rivas, Leticia Cuarental, Maria I. Ceballos, Arancha Pintor-Chocano, Maria Vanessa Perez-Gomez, Ana B. Sanz, Alberto Ortiz, Maria Dolores Sanchez-Niño Kidney Int
  Growth differentiation factor-15 (GDF15) is a member of the GDF subfamily with potential kidney protective functions. Here, we explored the impact of GDF15 on the expression of the kidney protective factor Klotho in models of acute kidney injury and kidney fibrosis in mice. GDF15 was the most (...) (Kidney International 101, 6 (2022))

16 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Concurrent vaccination of kidney transplant recipients and close household cohabitants against COVID-19 - Griffith B. Perkins, Matthew Tunbridge, Tania Salehi, Cheng Sheng Chai, Svjetlana Kireta, Julie Johnston, Daniella Penko, Jodie Nitschke, Arthur Eng Lip Yeow, Zahraa Al-Delfi, Christopher J. Drogemuller, Pablo Garcia-Valtanen, Makutiro G. Masavuli, Christopher M. Hope, Julian Singer, Anupriya Aggarwal, Alberto Ospina Stella, Stuart G. Turville, Plinio R. Hurtado, Simon C. Barry, Pravin Hissaria, Branka Grubor-Bauk, Steven J. Chadban, P. Toby Coates Kidney Int
  Kidney transplant recipients (KTRs) are highly vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severe coronavirus disease 2019 (COVID-19). The 28-day case mortality for KTRs is 24%, and mounting evidence suggests poor immunogenicity and clinical (...) (Kidney International 101, 5 (2022))

14 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Inferior humoral and sustained cellular immunity against wild-type and omicron variant of concern in hemodialysis patients immunized with 3 SARS-CoV-2 vaccine doses compared with 4 doses - Okan Cinkilic, Moritz Anft, Arturo Blazquez-Navarro, Toni L. Meister, Toralf Roch, Ulrik Stervbo, Stephanie Pfaender, Timm H. Westhoff, Nina Babel Kidney Int
  Studies analyzing humoral immunity against the most recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern omicron (B.1.1.529) in the general population demonstrate a clear benefit of an additional boost with respect to neutralization capacity,1 and several (...) (Kidney International 101, 6 (2022))

10 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Americentrism in estimation of glomerular filtration rate equations - Pierre Delanaye, Hans Pottel, Richard J. Glassock Kidney Int
  Social determinants of racial health disparities in kidney disease have an important role as environmental components, especially for Black populations, who are disproportionately disadvantaged, as Black Americans have a much higher risk for progression to kidney failure. The debate concerning (...) (Kidney International 101, 5 (2022))

8 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Hypomorphic expression of parathyroid Bmal1 disrupts the internal parathyroid circadian clock and increases parathyroid cell proliferation in response to uremia - Søren Egstrand, Maria Lerche Mace, Marya Morevati, Anders Nordholm, Lars Henning Engelholm, Jesper Skovhus Thomsen, Annemarie Brüel, Tally Naveh-Many, Yuliu Guo, Klaus Olgaard, Ewa Lewin Kidney Int
  The molecular circadian clock is an evolutionary adaptation to anticipate recurring changes in the environment and to coordinate variations in activity, metabolism and hormone secretion. Parathyroid hyperplasia in uremia is a significant clinical challenge. Here, we examined changes in the (...) (Kidney International 101, 6 (2022))
• 00:00
  Cubilin and amnionless protein are novel target antigens in anti–brush border antibody disease - Johann Morelle, Tiffany Caza, Hanna Debiec, Selda Aydin, Aaron Storey, Pierre Ronco, Christopher Larsen Kidney Int
  The kidney proximal tubule reabsorbs large amounts of low-molecular-weight proteins, albumin, electrolytes, and solutes from the glomerular filtrate to the systemic circulation. Alteration of the specialized transport systems that operate in the brush border of proximal tubule cells leads to (...) (Kidney International 101, 5 (2022))
• 00:00
  Kidney repair and regeneration: perspectives of the NIDDK (Re)Building a Kidney consortium - Bilal A. Naved, Joseph V. Bonventre, Jeffrey A. Hubbell, Neil A. Hukriede, Benjamin D. Humphreys, Carl Kesselman, M. Todd Valerius, Andrew P. McMahon, Stuart J. Shankland, Jason A. Wertheim, Michael J.V. White, Mark P. de Caestecker, Iain A. Drummond Kidney Int
  Acute kidney injury impacts ?13.3 million individuals and causes ?1.7 million deaths per year globally. Numerous injury pathways contribute to acute kidney injury, including cell cycle arrest, senescence, inflammation, mitochondrial dysfunction, and endothelial injury and dysfunction, and can (...) (Kidney International 101, 5 (2022))

7 March

Kidney Int http://www.kidney-international.org/

• 00:00
  High-sensitivity cardiac troponin and the diagnosis of myocardial infarction in patients with kidney impairment - Peter J. Gallacher, Eve Miller-Hodges, Anoop S.V. Shah, Tariq E. Farrah, Nynke Halbesma, James P. Blackmur, Andrew R. Chapman, Philip D. Adamson, Atul Anand, Fiona E. Strachan, Amy V. Ferry, Kuan Ken Lee, Colin Berry, Iain Findlay, Anne Cruickshank, Alan Reid, Alasdair Gray, Paul O. Collinson, Fred S. Apple, David A. McAllister, Donogh Maguire, Keith A.A. Fox, Catriona Keerie, Christopher J. Weir, David E. Newby, Nicholas L. Mills, Neeraj Dhaun, (...) Kidney Int
  The benefit and utility of high-sensitivity cardiac troponin (hs-cTn) in the diagnosis of myocardial infarction in patients with kidney impairment is unclear. Here, we describe implementation of hs-cTnI testing on the diagnosis, management, and outcomes of myocardial infarction in patients with (...) (Kidney International 102, 1 (2022))

6 March

Kidney Int http://www.kidney-international.org/

• 00:00
  The calcium-sensing receptor stabilizes podocyte function in proteinuric humans and mice - Anne K. Mühlig, Johanna Steingröver, Hannah S. Heidelbach, Madelaine Wingerath, Wiebke Sachs, Irm Hermans-Borgmeyer, Catherine Meyer-Schwesinger, Hoon Young Choi, Beom Jin Lim, Christian Patry, Georg Friedrich Hoffmann, Nicole Endlich, Katharina Bracke, Mariella Weiß, Andreas H. Guse, Moritz Lassé, Markus M. Rinschen, Fabian Braun, Tobias B. Huber, Victor G. Puelles, Claus Peter Schmitt, Jun Oh Kidney Int
  Calcimimetic agents allosterically increase the calcium ion sensitivity of the calcium-sensing receptor (CaSR), which is expressed in the tubular system and to a lesser extent in podocytes. Activation of this receptor can reduce glomerular proteinuria and structural damage in proteinuric animal (...) (Kidney International 101, 6 (2022))
• 00:00
  Progression of established non-diabetic chronic kidney disease is halted by metformin treatment in rats - Raphaëlle Corremans, Ellen Neven, Stuart Maudsley, Hanne Leysen, Marc E. De Broe, Patrick C. D’Haese, Benjamin A. Vervaet, Anja Verhulst Kidney Int
  Current treatment strategies for chronic kidney disease (CKD) mainly focus on controlling risk factors. Metformin, a first-line drug for type 2 diabetes, exerts beneficial pleiotropic actions beyond its prescribed use and incipient data have revealed protective effects against the development (...) (Kidney International 101, 5 (2022))

1 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Table of Contents Kidney Int
  (Kidney International 101, 3 (2022))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 101, 3 (2022))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 101, 3 (2022))
• 00:00
  Don’t deny it! Incremental dialysis is compassionate, logical, and patient-centered - Elizabeth Lindley, James Tattersall Kidney Int
  The 2020 International Society for Peritoneal Dialysis guideline defines incremental peritoneal dialysis (PD) as “a strategy by which less than standard ‘full-dose’ PD is prescribed in people initiating PD, with the intention of increasing the peritoneal prescription if and when residual kidney (...) (Kidney International 101, 3 (2022))
• 00:00
  The safety and feasibility of incremental dialysis must be proven before its widespread use - Christoph Wanner, Kai Lopau, Henrike Haberstroh Kidney Int
  Incremental dialysis has a long history of use in kidney replacement therapy and is mainly applied to selected individuals commencing maintenance hemodialysis (MHD) and peritoneal dialysis (PD). Most individuals with end-stage kidney disease reluctantly start on maintenance dialysis, mostly due (...) (Kidney International 101, 3 (2022))
• 00:00
  Initiation of maintenance dialysis: back to the future - T. Alp Ikizler Kidney Int
  Since the very first conceptualization of clearance of toxins by means of dialysis more than a century ago, maintenance dialysis has become a life-sustaining routine treatment, without which more than a million people throughout the world with limited or no kidney function would quickly die.1 (...) (Kidney International 101, 3 (2022))
• 00:00
  In this issue Kidney Int
  Heart failure and kidney failure often occur together and generally portend a poor outcome for patients. Kitani et al. developed a unique model of unilateral kidney congestion to study the pathophysiology of the kidney during heart failure by inferior vena cava constriction. The congested (...) (Kidney International 101, 3 (2022))
• 00:00
  Journal Club Kidney Int
  Kers et al. (Lancet Digit Health. 2022;4:e18–e26.) (Kidney International 101, 3 (2022))
• 00:00
  Corrigendum to Tsuchiyama Y, Wada J, Zhang H, et al. Efficacy of galectins in the amelioration of nephrotoxic serum nephritis in Wistar Kyoto rats. Kidney Int. 2000;58:1941–1952 Kidney Int
  In the above-stated article, the authors mistakenly placed a different experimental group in Figure 3i. Figure 3i now contains the correct experimental group. (Kidney International 101, 3 (2022))
• 00:00
  Corrigendum to Balbo BE, Amaral AG, Fonseca JM, et al. Cardiac dysfunction in Pkd1-deficient mice with phenotype rescue by galectin-3 knockout. Kidney Int. 2016;90:580–597 Kidney Int
  In the above-stated article, in Figure 8i, due to the similarity between the wild-type (WT) and Pkd1cond/cond (NC) images, the image of NC was inadvertently duplicated in the WT position. Figure 8i now contains the correct image in the WT (...) (Kidney International 101, 3 (2022))
• 00:00
  Modeling pulse wave velocity trajectories—challenges, opportunities, and pitfalls - Georg Heinze, Jeppe Christensen, Maria C. Haller Kidney Int
  In this commentary, we discuss the analysis of trajectories of pulse wave velocity in a longitudinal cohort study of children with chronic kidney disease (the Cardiovascular Comorbidity in Children with Chronic Kidney Disease – Transplantation study). We revisit the analysis made by the study (...) (Kidney International 101, 3 (2022))
• 00:00
  Sex differences in cardiovascular disease burden in children with chronic kidney disease - Ashlene M. McKay, Chia Wei Teoh Kidney Int
  Cardiovascular disease is the leading cause of death in children and adults with chronic kidney disease. In this issue, Sugianto et al. demonstrated signs of increased cardiovascular damage (vascular stiffness) in children with chronic kidney disease and highlighted an increased susceptibility (...) (Kidney International 101, 3 (2022))
• 00:00
  Anemia and red blood cell deformability in proteinuric chronic kidney disease - Jaap A. Joles Kidney Int
  Bissinger et al. recently reported that proteinuric chronic kidney disease, in both mice and humans, is associated with reduced red blood cell (RBC) deformability and increased RBC lysophospholipid content.1 Blood albumin levels were not reported but presumably were low in mice with (...) (Kidney International 101, 3 (2022))
• 00:00
  The authors reply - Rosi Bissinger, Bernhard N. Bohnert, Travis Nemkov, Ferruh Artunc Kidney Int
  Dr. Joles recently commented1 on our article,2 discussing the possible implications of hypoalbuminemia, proteinuria, or uremia for the reduced deformability of red blood cells (RBCs) in the 2 proteinuric mouse models of kidney disease–associated anemia investigated in our study.2 In a previous (...) (Kidney International 101, 3 (2022))
• 00:00
  Daratumumab for multidrug-resistant phospholipase-A2 receptor–related membranous nephropathy - Coralien H. Vink, Bram van Cranenbroek, Joost W. van der Heijden, Hans P.J.M. Koenen, Jack F.M. Wetzels Kidney Int
  At least 10% of patients with anti–phospholipase-A2 receptor antibody (aPLA2R)–associated membranous nephropathy do not attain immunologic remission with standard therapies. Anti–plasma cell therapy with bortezomib has been suggested.1,2 We report the disease course in a patient treated with (...) (Kidney International 101, 3 (2022))
• 00:00
  LPCing through the nephron accelerates diabetic kidney disease - Jeffrey D. Pressly, Mengyuan Ge, Alessia Fornoni Kidney Int
  Lipid dysmetabolism is emerging as an important contributor to diabetic kidney disease, suggesting that intrarenal lipid accumulation is detrimental to kidney function. This commentary discusses the finding by Yoshioka et al., connecting tubular lipotoxicity induced by an increase in locally (...) (Kidney International 101, 3 (2022))
• 00:00
  Mathematical modeling of hemodialysis: a tribute to John A. Sargent, PhD (1939–2020) - José A. Moura-Neto, John T. Daugirdas Kidney Int
  While good men of science generally discuss ideas and make their contributions with relevant information to the field, legends pave the way and create the basis for what we know today. This was precisely what Dr. John Sargent (Figure 1) did. Dr. Sargent died on December 4, 2020, at the age of (...) (Kidney International 101, 3 (2022))
• 00:00
  mTOR signaling cascade: novel clinical implications in HLA and non-HLA antibody-mediated vasculopathies? - Kevin Louis, Alexandre Loupy, Carmen Lefaucheur Kidney Int
  Antibodies targeting endothelial antigens represent major threats to the integrity of endothelial vasculature, contributing to development of organ transplant rejection and vasculopathies. In this issue, Catar et al. present the mechanisms by which non-human leukocyte antigen angiotensin II (...) (Kidney International 101, 3 (2022))
• 00:00
  Sortilin, carbamylation, and cardiovascular calcification in chronic kidney disease - Ziad A. Massy, Sophie Liabeuf Kidney Int
  Sortilin appears to play important roles in the pathogenesis of vascular and metabolic diseases, such as cardiovascular calcification. Post-translational modifications of sortilin (i.e., phosphorylation or carbamylation) are among the key mechanisms of its actions. Recent data extended the role (...) (Kidney International 101, 3 (2022))
• 00:00
  The authors reply: - Kavita Gulati, Helena Edwards, Maria Prendecki, Charles D. Pusey, Stephen P. McAdoo Kidney Int
  We thank Drs. Cheng and Gou for their interest in our article.1,2 We agree that there are important differences relating to the use of i.v. methylprednisolone in the Methylprednisolone versus plasma exchange (MEPEX) and Plasma exchange and glucocorticoid dosing in the treatment of (...) (Kidney International 101, 3 (2022))
• 00:00
  Whether the addition of high-dosage methylprednisolone to plasma exchange was more effective than plasma exchange in the treatment for severe antineutrophil cytoplasmic antibody–associated vasculitis? - Lu Cheng, Shen-Ju Gou Kidney Int
  We read with great interest the recent contribution by Gulati et al.1 They retrospectively investigated the effect of a combination regimen of plasma exchange, rituximab, low-dose i.v. cyclophosphamide, and oral glucocorticoids for the treatment of severe anti–neutrophil cytoplasmic (...) (Kidney International 101, 3 (2022))
• 00:00
  The Case | Hypereosinophilia in a hemodialysis patient - Gaspard Lamy, Jean-Emmanuel Kahn, Tessa Huscenot, Mathilde Dargelos, Eve Vilaine, Aymeric Couturier, Panha Chhom, Hamza Ayari, Ziad Albert Massy, Marie Essig Kidney Int
  A 73-year-old man with end-stage kidney disease due to presumed diabetic nephropathy began hemodialysis in July 2020. He was referred with severe hypereosinophilia, which was progressively worsening since September 2020, with a peak eosinophil count of 40.7 × 109/L (...) (Kidney International 101, 3 (2022))
• 00:00
  Valproic acid–associated proximal tubulopathy - Satoru Kudose, Marissa Lipton, Namrata G. Jain, Vivette D. D’Agati Kidney Int
  A 6-year-old Asian boy with ring chromosome 14, global developmental delay, seizure disorder, asthma, chronic respiratory failure requiring ventilatory support, and gastrostomy tube dependence presented with acute kidney injury and Fanconi syndrome. He had been treated with valproic acid (800 (...) (Kidney International 101, 3 (2022))
• 00:00
  Posaconazole-induced podocyte phospholipidosis - Sarwat Gilani, Samih H. Nasr, Sanjeev Sethi Kidney Int
  Podocyte lysosomal vacuolization can be seen in proteinuric diseases, in lysosomal storage diseases, such as Fabry disease, and in association with drugs, such as hydroxychloroquine. A 20-year-old woman underwent heart transplant in 2001 for left hypoplastic heart syndrome. She developed (...) (Kidney International 101, 3 (2022))
• 00:00
  Renal infarction due to COVID-19–associated renal mucormycosis - Anila Abraham Kurien, Nagalakshmi Dhanapal Srinivasaprasad, Kaliyaperumal Thirumal Valavan Kidney Int
  A 32-year-old man, with no comorbidities, was admitted with severe coronavirus disease 2019 (COVID-19) pneumonia. Remdesivir, enoxaparin, methylprednisolone sodium succinate, and tocilizumab were administered, and the patient was put on continuous positive airway pressure therapy. His clinical (...) (Kidney International 101, 3 (2022))

28 February

Kidney Int http://www.kidney-international.org/

• 00:00
  Deficiency of the kidney tubular angiotensin II type1 receptor–associated protein ATRAP exacerbates streptozotocin-induced diabetic glomerular injury via reducing protective macrophage polarization - Kotaro Haruhara, Toru Suzuki, Hiromichi Wakui, Kengo Azushima, Daisuke Kurotaki, Wataru Kawase, Kazushi Uneda, Ryu Kobayashi, Kohji Ohki, Sho Kinguchi, Takahiro Yamaji, Ikuma Kato, Kenichi Ohashi, Akio Yamashita, Tomohiko Tamura, Nobuo Tsuboi, Takashi Yokoo, Kouichi Tamura Kidney Int
  Although activation of the renin-angiotensin system and of its glomerular components is implicated in the pathogenesis of diabetic nephropathy, the functional roles of the tubular renin-angiotensin system with AT1 receptor signaling in diabetic nephropathy are unclear. Tissue hyperactivity of (...) (Kidney International 101, 5 (2022))

26 February

Kidney Int http://www.kidney-international.org/

• 00:00
  When the pooled CRISPR screen meets kidney organoids: toward the identification of new genes and pathways - Chao Zhang, Yun Xia Kidney Int
  Nowadays, genomic sequencing data are being generated at a speed that has outstripped the pace of annotation. Loss-of-function CRISPR screens have been used as a high-throughput approach to determine the functional relevance of individual genes in a specific phenotype by ablating gene (...) (Kidney International 101, 6 (2022))
• 00:00
  A fourth dose of the mRNA-1273 SARS-CoV-2 vaccine improves serum neutralization against the Delta variant in kidney transplant recipients - Ilies Benotmane, Timothée Bruel, Delphine Planas, Samira Fafi-Kremer, Olivier Schwartz, Sophie Caillard Kidney Int
  Research has suggested that even 3 doses of severe acute respiratory syndrome coronavirus 2 mRNA-based vaccines might be unable to elicit a sufficient immune response in immunocompromised kidney transplant recipients.1,2 Although the antibody response mounted by the Pfizer and AstraZeneca (...) (Kidney International 101, 5 (2022))
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  Antibody responses to 2 doses of mRNA COVID-19 vaccine in pediatric patients with kidney diseases - Alison Lap-Tak Ma, Daniel Leung, Eugene Yu-Hin Chan, Stella Chim, Samuel Cheng, Fanny Tsz-Wai Ho, Wai-Ming Lai, Pak-Chiu Tong, Matthew Hon-Lam Lee, Wilfred Hing-Sang Wong, Sau Man Chan, Jaime Rosa Duque, Joseph Sriyal Malik Peiris, Yu Lung Lau Kidney Int
  Studies in adult patients with kidney diseases have shown an attenuated immune response to natural coronavirus disease 2019 (COVID-19) and COVID-19 vaccination.1 The pivotal trial of BNT162b2 demonstrated a far higher neutralizing antibody titer in adolescents than in adults.2 Yet, the (...) (Kidney International 101, 5 (2022))

25 February

Kidney Int http://www.kidney-international.org/

• 00:00
  Early increase in single-kidney glomerular filtration rate after living kidney donation predicts long-term kidney function - Jessica van der Weijden, Shekar V.K. Mahesh, Marco van Londen, Stephan J.L. Bakker, Jan-Stephan Sanders, Gerjan Navis, Robert A. Pol, Joke I. Roodnat, Marcia M.L. Kho, Derya Yakar, Thomas C. Kwee, Ilja M. Nolte, Stefan P. Berger, Martin H. De Borst Kidney Int
  Single-kidney glomerular filtration rate (GFR) increases after living kidney donation due to compensatory hyperfiltration and structural changes. The implications of inter-individual variability in this increase in single-kidney GFR are unknown. Here, we aimed to identify determinants of the (...) (Kidney International 101, 6 (2022))
• 00:00
  Mixed-methods research in nephrology - Pippa K. Bailey, Barnaby D. Hole, Lucy A. Plumb, Fergus J. Caskey Kidney Int
  Mixed-methods research involves the mixing of at least 1 qualitative and 1 quantitative method in the same research project or set of related projects. Combined use of qualitative and quantitative research methods in nephrology has increased over the last 10 years. In this review, we aim to (...) (Kidney International 101, 5 (2022))
• 00:00
  Digital spatial profiling of collapsing glomerulopathy - Kelly D. Smith, David K. Prince, Kammi J. Henriksen, Roberto F. Nicosia, Charles E. Alpers, Shreeram Akilesh Kidney Int
  Collapsing glomerulopathy is a histologically distinct variant of focal and segmental glomerulosclerosis that presents with heavy proteinuria and portends a poor prognosis. Collapsing glomerulopathy can be triggered by viral infections such as HIV or SARS-CoV-2. Transcriptional profiling of (...) (Kidney International 101, 5 (2022))
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  Association of cardiac autonomic neuropathy assessed by heart rate response during exercise with intradialytic hypotension and mortality in hemodialysis patients - Naoto Usui, Junichiro Nakata, Akimi Uehata, Shuji Ando, Masakazu Saitoh, Sho Kojima, Akihito Inatsu, Hideki Hisadome, Yusuke Suzuki Kidney Int
  The heart rate (HR) reflects the dynamic behavior of the autonomic nervous system, and HR profiles during the exercise test provide prognostic information. However, there are no reports of these factors in hemodialysis patients. Data from 256 patients (mean 68.8 years old) who underwent an (...) (Kidney International 101, 5 (2022))
• 00:00
  Biallelic pathogenic variants in roundabout guidance receptor 1 associate with syndromic congenital anomalies of the kidney and urinary tract - Johannes Münch, Marie Engesser, Ria Schönauer, J. Austin Hamm, Christin Hartig, Elena Hantmann, Gulsen Akay, Davut Pehlivan, Tadahiro Mitani, Zeynep Coban Akdemir, Beyhan Tüysüz, Toshihiko Shirakawa, Sumito Dateki, Laura R. Claus, Albertien M. van Eerde, Genomics England Research Consortium, Thomas Smol, Louise Devisme, Hélène Franquet, Tania Attié-Bitach, Timo Wagner, Carsten Bergmann, Anne Kathrin Höhn, Shirlee Shril, Ari Pollack, Tara Wenger, Abbey A. Scott, Sarah Paolucci, Jillian Buchan, George C. Gabriel, Jennifer E. Posey, James R. Lupski, Florence Petit, Andrew A. McCarthy, Gregory J. (...) Kidney Int
  Congenital anomalies of the kidney and urinary tract (CAKUT) represent the most common cause of chronic kidney failure in children. Despite growing knowledge of the genetic causes of CAKUT, the majority of cases remain etiologically unsolved. Genetic alterations in roundabout guidance receptor (...) (Kidney International 101, 5 (2022))
• 00:00
  Conditional deletion of myeloid-specific mitofusin 2 but not mitofusin 1 promotes kidney fibrosis - Divya Bhatia, Allyson Capili, Kiichi Nakahira, Thangamani Muthukumar, Lisa K. Torres, Augustine M.K. Choi, Mary E. Choi Kidney Int
  Macrophages exert critical functions during kidney injury, inflammation, and tissue repair or fibrosis. Mitochondrial structural and functional aberrations due to an imbalance in mitochondrial fusion/fission processes are implicated in the pathogenesis of chronic kidney disease. Therefore, we (...) (Kidney International 101, 5 (2022))
• 00:00
  Nuclear farnesoid X receptor attenuates acute kidney injury through fatty acid oxidation - Sujuan Xu, Ping Jia, Yi Fang, Jifu Jin, Zhaoxing Sun, Weiran Zhou, Jie Li, Yunlu Zhang, Xiaoyan Wang, Ting Ren, Zhouping Zou, Xiaoqiang Ding Kidney Int
  Acute kidney injury (AKI) is a life-threatening condition that is one of most common side effects of cisplatin therapy. Fatty acid oxidation (FAO) is the main source of energy production in kidney proximal tubular epithelial cells (PTECs) but it is inhibited in AKI. Recent work demonstrated (...) (Kidney International 101, 5 (2022))

21 February

Kidney Int http://www.kidney-international.org/

• 00:00
  Adverse changes in key chronic kidney disease care outcome metrics since the onset of the COVID-19 pandemic: experience from an established provincial renal program - Micheli Bevilacqua, Dilshani Induruwage, Janet Williams, Ognjenka Djurdjev, Adeera Levin Kidney Int
  The onset of the coronavirus disease 2019 (COVID-19) pandemic has resulted in a profound disruption to existing clinical services including chronic kidney disease (CKD) management.1 In the province of British Columbia (BC), Canada, following the onset of the pandemic, dramatic changes in health (...) (Kidney International 101, 5 (2022))

14 February

Kidney Int http://www.kidney-international.org/

• 00:00
  COVID-19 in dialysis: clinical impact, immune response, prevention, and treatment - Khalil El Karoui, An S. De Vriese Kidney Int
  The COVID-19 pandemic has profound adverse effects on the population on dialysis. Patients requiring dialysis are at an increased risk of SARS-CoV-2 infection and mortality, and many have experienced psychological distress as well as delayed or suboptimal care. COVID-19 survivors have prolonged (...) (Kidney International 101, 5 (2022))

12 February

Kidney Int http://www.kidney-international.org/

• 00:00
  Role of uremic toxins in vascular disease—the end of nihilism? - Ziad A. Massy, Tilman B. Drueke Kidney Int
  The liver and kidneys are the main organs involved in the metabolism and elimination of carbohydrates, fats, and proteins, as well as their breakdown products. When kidney or liver function is impaired, these metabolites accumulate and contribute to the clinical features of advanced liver (...) (Kidney International 101, 6 (2022))
• 00:00
  Is HIF activation Janus faced? The therapeutic effects of the HIF-2? inhibitor - Taisuke Ishii, Tetsuhiro Tanaka, Masaomi Nangaku Kidney Int
  von Hippel-Lindau (VHL) disease is a rare autosomal dominant hereditary syndrome that is caused by biallelic VHL inactivation following Knudson’s 2-hit hypothesis of tumorigenesis. Although VHL disease presents with variable phenotypes, inactivation of the VHL protein causes benign and malignant (...) (Kidney International 101, 5 (2022))
• 00:00
  A fourth SARS-CoV-2 mRNA vaccine in strictly seronegative kidney transplant recipients - Christophe Masset, Ilies Benotmane, Jacques Dantal, Claire Garandeau, Gabriella Gauthier-Vargas, Diego Cantarovich, Aurélie Meurette, Magali Giral, Sophie Caillard, Gilles Blancho Kidney Int
  Solid organ transplant recipients have demonstrated a lower humoral immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination, leading transplant physicians to perform a third vaccine injection.1 However, despite this early booster, about 35% of patients (...) (Kidney International 101, 4 (2022))

11 February

Kidney Int http://www.kidney-international.org/

• 00:00
  Breakthrough omicron COVID-19 infections in patients receiving the REGEN-Cov antibody combination - Adrien Flahault, Justine Touchard, Hélène Péré, Laetitia Ulrich, Brigitte Sabatier, David Veyer, David Lebeaux, Eric Thervet Kidney Int
  Coronavirus disease 2019 (COVID-19) vaccines are efficient to prevent severe COVID-19 infections. Immunocompromised patients are at increased risk of both severe COVID-19 and poor immunologic response to anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (...) (Kidney International 101, 4 (2022))
• 00:00
  Letter regarding “diagnosis and treatment of arterial hypertension 2021” - Joachim H. Ix, Charles R.V. Tomson, Alfred K. Cheung, Johannes F.E. Mann, William C. Cushman, Michael Cheung, Tara I. Chang Kidney Int
  We applaud Kidney International for its new series focused on hypertension. As members of the Kidney Disease: Improving Global Outcomes (KDIGO) 2021 Blood Pressure (BP) Guideline writing committee, we worked to design a guideline that would save lives and improve quality of life for chronic (...) (Kidney International 101, 4 (2022))
• 00:00
  The authors reply - Christian Ott, Roland E. Schmieder Kidney Int
  We thank the editor for giving us the opportunity to reply to the letter by Ix et al.1 We acknowledge the honest intention by the Kidney Disease: Improving Global Outcomes (KDIGO) blood pressure (BP) guideline to save lives and improve quality of life for chronic kidney disease (CKD) patients (...) (Kidney International 101, 4 (2022))

3 February

Kidney Int http://www.kidney-international.org/

• 00:00
  A comprehensive assessment of long-term SARS-CoV-2–specific adaptive immune memory in convalescent COVID-19 Solid Organ Transplant recipients - Alexandre Favà, Laura Donadeu, Thomas Jouve, José Gonzalez-Costello, Laura Lladó, Carolina Santana, Néstor Toapanta, Manuel Lopez, Vincent Pernin, Carme Facundo, Nuria Serra Cabañas, Olivier Thaunat, Marta Crespo, Laura Llinàs-Mallol, Ignacio Revuelta, Nuria Sabé, Alexander Rombauts, Laura Calatayud, Carmen Ardanuy, Juliana Esperalba, Candela Fernandez, Juan J. Lozano, Rosemarie Preyer, Kevin Strecker, Carlos Couceiro, Elena García-Romero, Alba Cachero, Maria Meneghini, Alba Torija, Moglie Le Quintrec, Edoardo Melilli, Josep Maria Cruzado, Carolina Polo, Francesc Moreso, Elena Crespo, Oriol (...) Kidney Int
  Long-term adaptive immune memory has been reported among immunocompetent individuals up to eight months following SARS-CoV-2 infection. However, limited data is available in convalescent patients with a solid organ transplant. To investigate this, we performed a thorough evaluation of adaptive (...) (Kidney International 101, 5 (2022))

1 February

Kidney Int http://www.kidney-international.org/

• 00:00
  Inhibition of endoplasmic reticulum stress signaling rescues cytotoxicity of human apolipoprotein-L1 risk variants in Drosophila - Lea Gerstner, Mengmeng Chen, Lina L. Kampf, Julian Milosavljevic, Konrad Lang, Ronen Schneider, Friedhelm Hildebrandt, Martin Helmstädter, Gerd Walz, Tobias Hermle Kidney Int
  Risk variants of the apolipoprotein-L1 (APOL1) gene are associated with severe kidney disease, putting homozygous carriers at risk. Since APOL1 lacks orthologs in all major model organisms, a wide range of mechanisms frequently in conflict have been described for APOL1-associated nephropathies. (...) (Kidney International 101, 6 (2022))
• 00:00
  Trans-ethnic genome-wide association study of blood metabolites in the Chronic Renal Insufficiency Cohort (CRIC) study - Eugene P. Rhee, Aditya Surapaneni, Zihe Zheng, Linda Zhou, Diptavo Dutta, Dan E. Arking, Jingning Zhang, ThuyVy Duong, Nilanjan Chatterjee, Shengyuan Luo, Pascal Schlosser, Rupal Mehta, Sushrut S. Waikar, Santosh L. Saraf, Tanika N. Kelly, Lee L. Hamm, Panduranga S. Rao, Anna V. Mathew, Chi-yuan Hsu, Afshin Parsa, Ramachandran S. Vasan, Paul L. Kimmel, Clary B. Clish, Josef Coresh, Harold I. Feldman, Morgan E. Grams, CKD Biomarkers Consortium and the Chronic Renal Insufficiency Cohort (CRIC) Study (...) Kidney Int
  Metabolomics genome wide association study (GWAS) help outline the genetic contribution to human metabolism. However, studies to date have focused on relatively healthy, population-based samples of White individuals. Here, we conducted a GWAS of 537 blood metabolites measured in the Chronic (...) (Kidney International 101, 4 (2022))
• 00:00
  Table of Contents Kidney Int
  (Kidney International 101, 2 (2022))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 101, 2 (2022))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 101, 2 (2022))
• 00:00
  In this issue Kidney Int
  The unintended consequences of antidiabetic medications have proven to be a win for the kidneys. Several oral agents have robust kidney and cardioprotective effects. A cohort study by Xu et al. extends these observations to the glucagon-like peptide-1 receptor agonists (GLP1-RAs). The kidney (...) (Kidney International 101, 2 (2022))
• 00:00
  Journal Club Kidney Int
  Jorge et al. (Arthritis Care Res [Hoboken]. Published online June 13, 2021. https://doi.org/10.1002/acr.24725) (Kidney International 101, 2 (2022))
• 00:00
  BLISS-LN trial revisited: function matters - Sarah Gleeson, Liz Lightstone Kidney Int
  This post hoc analysis of the Belimumab International Study in Lupus Nephritis (BLISS-LN) shows belimumab effectively reduced the time to 30% and 40% decreases in estimated glomerular filtration rate and persistent decreases in estimated glomerular filtration rate. Subgroup analysis found (...) (Kidney International 101, 2 (2022))
• 00:00
  AA amyloidosis without systemic inflammation: when clinical evidence validates predictions of experimental medicine - Laura Obici, Vittorio Bellotti Kidney Int
  Amyloid A (AA) amyloidosis is a well-known consequence of chronic inflammatory diseases in which elevated plasma concentrations of serum amyloid A result in amyloid aggregation and organ damage. In this issue, Sikora et al. report, for the first time, an inherited form of AA amyloidosis (...) (Kidney International 101, 2 (2022))
• 00:00
  Lipoic acid in neural epidermal growth factor-like 1–associated membranous nephropathy: more than a coincidence? - Tiffany N. Caza, Christopher P. Larsen Kidney Int
  We found the study by Spain et al., “Lipoic Acid Supplementation Associated With Neural Epidermal Growth Factor-Like 1 (NELL1)–Associated Membranous Nephropathy,” to be of great interest.1 We performed a retrospective review of medications in 115 patients with NELL1-positive membranous nephropathy (...) (Kidney International 101, 2 (2022))
• 00:00
  Murine models of uremic cardiomyopathy as a necessary tool to unravel mechanisms involved in cardiorenal syndrome - José Alberto Navarro-García, Gema Ruiz-Hurtado Kidney Int
  Chronic kidney disease (CKD) and cardiovascular disease frequently run in parallel. Herein, Soppert et al. provide an interesting meta-analysis of the effects of CKD on cardiac remodeling and/or function in mice based on the model, strain, and duration. The authors sought to determine the most (...) (Kidney International 101, 2 (2022))
• 00:00
  Insights into vitamin K metabolism in chronic kidney disease: more complicated than kale deficiency - Jennifer S. Lees, Patrick B. Mark Kidney Int
  Vascular calcification is a major manifestation of cardiovascular disease in advanced chronic kidney disease and is inhibited by vitamin K–dependent proteins. Clinical trials of vitamin K supplementation in chronic kidney disease have failed to demonstrate benefits on vascular calcification. (...) (Kidney International 101, 2 (2022))
• 00:00
  Addressing screams for evidence on renoprotection by GLP-1 receptor agonists - Takayoshi Sasako, Toshimasa Yamauchi Kidney Int
  Although growing evidence supports the benefits of glucagon-like peptide-1 receptor agonists, the renoprotective effects were not fully proven in clinical trials. Now, Xu et al. show that glucagon-like peptide-1 receptor agonists reduce the renal outcome compared with dipeptidyl peptidase-4 (...) (Kidney International 101, 2 (2022))
• 00:00
  The authors reply: - Xiubin Li, Junnan Xu Kidney Int
  We thank Calmont1 for her interest in our research focusing on the protection effect of the Semaphorin 4A (Sema4A)–neuropilin-1 (Nrp1) axis on kidney ischemia-reperfusion injury (IRI). Calmont1 pointed out that Xia et al.2 did not find changes in either kidney function or damage in (...) (Kidney International 101, 2 (2022))
• 00:00
  Sema4A-Nrp1 versus Sema4A-plexinB2 in the acutely damaged kidney - Amélie Calmont Kidney Int
  I read with great interest the article by Xu et al., recently published in Kidney International.1 This study reported that Semaphorin 4A (Sema4A) systemic delivery could help recruit neuropilin-1 (Nrp1)–positive regulatory T cells to the kidney and alleviate ischemia-reperfusion injury (IRI). (...) (Kidney International 101, 2 (2022))
• 00:00
  Corrigendum to Cai J, Liu Z, Huang X, et al. The deacetylase sirtuin 6 protects against kidney fibrosis by epigenetically blocking ?-catenin target gene expression Kidney Int. 2020;97:106–118 Kidney Int
  In the above-stated article, in the lower panels of Figure 1a and d, the authors mistakenly used the same Masson staining image for the Sham groups of unilateral ureteral obstruction and ischemia-reperfusion (uIR) models. Figure 1 now contains the correct Masson staining of the Sham group in (...) (Kidney International 101, 2 (2022))
• 00:00
  Urine, doctors, and the acanthocyte’s 30th birthday - Daniel Kraus, Hans Köhler, Julia Weinmann-Menke Kidney Int
  Thirty years ago, in 1991, Kidney International published a seminal article by Hans Köhler, Eveline Wandel, and Bernd Brunck of the University of Mainz, Germany. This article was the first to call peculiarly shaped erythrocytes in the urine “acanthocytes,” and it was the first to systematically (...) (Kidney International 101, 2 (2022))
• 00:00
  The changing role of glucocorticoids in the treatment of anti–neutrophil cytoplasmic antibody–associated vasculitis - Neeraj Dhaun, Stephen P. McAdoo Kidney Int
  Glucocorticoids (GCs) have been a cornerstone of treatment for patients with anti–neutrophil cytoplasm antibody–associated vasculitis (AAV) for decades. They were first used as monotherapy for “polyarteritis” in the 1950s,1,2 and then successfully combined with cyclophosphamide in the 1970s.3 Since (...) (Kidney International 101, 2 (2022))
• 00:00
  Anti-CD38 therapy for PLA2R-positive membranous nephropathy resistant to conventional immunosuppression - Thomas Stehlé, Philippe Grimbert, Philippe Remy, Anissa Moktefi, Vincent Audard, Khalil El Karoui Kidney Int
  In their letter, Salhi et al.1 report a case of phospholipase A2 receptor–positive (PLA2R+) membranous nephropathy (MN) remission after bortezomib treatment, a proteasome inhibitor targeting plasma cells. (Kidney International 101, 2 (2022))
• 00:00
  The Case | An unusual cause of renal vascular thrombi after kidney transplantation - Pauline Erpicum, Stéphanie Grosch, Catherine Bonvoisin, Antoine Bouquegneau, Laurent Weekers, Luc Radermacher, François Jouret, Marie Lejeune, Olivier Hougrand, Christophe Bovy Kidney Int
  In 2008, a 36-year-old woman presented with edema of the lower limbs. Kidney function was normal. Urinalysis revealed nonselective glomerular proteinuria, with hematuria. The classical immune and serological workup was noncontributive. Renal biopsy revealed an immune complex–mediated (...) (Kidney International 101, 2 (2022))
• 00:00
  Noninvasive screening of vancomycin-associated cast nephropathy - Cédric Rafat, Jeremy Zaworski, Yosu Luque, Michel Daudon, Alice Doreille, Laurent Mesnard, Emmanuel Letavernier Kidney Int
  A 62-year-old male patient, weighing 85 kg, was initially admitted for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–related pneumonia complicated by acute respiratory distress syndrome, warranting mechanical ventilation. Initial kidney function was normal (plasma creatinine, 70 (...) (Kidney International 101, 2 (2022))
• 00:00
  Acute methotrexate-induced crystal nephropathy - Matthew F. Blum, Mohamed G. Atta Kidney Int
  A 79-year-old woman with primary diffuse large B-cell lymphoma of the central nervous system was admitted for high-dose methotrexate and rituximab administration. After receiving oral and isotonic i.v. sodium bicarbonate to achieve an alkaline urine pH, she received 4.96 g/m2 of i.v. (...) (Kidney International 101, 2 (2022))
• 00:00
  Diagnosis of AApoAIV medullary amyloidosis at radical nephrectomy - Paul E. Rosenstiel, Tahira Alves Kidney Int
  A 66-year-old man with end-stage kidney disease attributed to hypertension and diabetes presented with an incidental 1.8-cm lesion in the right kidney. A nephrectomy was performed and a benign hemorrhagic renal cyst (not shown) was identified. In addition, gross anatomic assessment of the (...) (Kidney International 101, 2 (2022))

31 January

Kidney Int http://www.kidney-international.org/

• 00:00
  Histologically resolved small RNA maps in primary focal segmental glomerulosclerosis indicate progressive changes within glomerular and tubulointerstitial regions - Anna Marie Williams, David M. Jensen, Xiaoqing Pan, Pengyuan Liu, Jing Liu, Sean Huls, Kevin R. Regner, Kenneth A. Iczkowski, Feng Wang, Junhui Li, Alexander J. Gallan, Tao Wang, Maria Angeles Baker, Yong Liu, Nava Lalehzari, Mingyu Liang Kidney Int
  Pathological heterogeneity is common in clinical tissue specimens and complicates the interpretation of molecular data obtained from the specimen. As a typical example, a kidney biopsy specimen often contains glomeruli and tubulointerstitial regions with different levels of histological injury, (...) (Kidney International 101, 4 (2022))
• 00:00
  Kidney health for all: bridging the gap in kidney health education and literacy - Robyn G. Langham, Kamyar Kalantar-Zadeh, Ann Bonner, Alessandro Balducci, Li-Li Hsiao, Latha A. Kumaraswami, Paul Laffin, Vassilios Liakopoulos, Gamal Saadi, Ekamol Tantisattamo, Ifeoma Ulasi, Siu-Fai Lui, World Kidney Day Joint Steering Committee Kidney Int
  The high burden of kidney disease, global disparities in kidney care, and poor outcomes of kidney failure bring a concomitant growing burden to persons affected, their families, and carers, and the community at large. Health literacy is the degree to which persons and organizations have or (...) (Kidney International 101, 3 (2022))

30 January

Kidney Int http://www.kidney-international.org/

• 00:00
  New-onset class III lupus nephritis with multi-organ involvement after COVID-19 vaccination - Hyo Jeong Kim, Minsun Jung, Beom Jin Lim, Seung Hyeok Han Kidney Int
  Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can trigger an autoimmune response. Two cases of lupus nephritis after the administration of the mRNA vaccine (BNT162b2, Pfizer–BioNTech) and the adenoviral vector vaccine (AZD1222 [ChAdOx1-S], AstraZeneca) have (...) (Kidney International 101, 4 (2022))