1 July

Kidney Int http://www.kidney-international.org/

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  Molecular profiling of kidney compartments from serial biopsies differentiate treatment responders from non-responders in lupus nephritis. - Samir V. Parikh, Ana Malvar, Huijuan Song, John Shapiro, Juan Manuel Mejia-Vilet, Isabelle Ayoub, Salem Almaani, Sethu Madhavan, Valeria Alberton, Celeste Besso, Bruno Lococo, Anjali Satoskar, Jianying Zhang, Lianbo Yu, Paolo Fadda, Michael Eadon, Dan Birmingham, Latha P. Ganesan, Wael Jarjour, Brad H. Rovin Kidney Int
  The immune pathways that define treatment response and non-response in lupus nephritis (LN) are unknown. To characterize these intra-kidney pathways, transcriptomic analysis was done on protocol kidney biopsies obtained at flare (initial biopsy (Bx1)) and after treatment (second biopsy (Bx2)) (...) (Kidney International (2022))
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  Indigenous peoples’ perspectives of living with chronic kidney disease: systematic review of qualitative studies - Marianne Kerr, Nicole Evangelidis, Penelope Abbott, Jonathan C. Craig, Michelle Dickson, Nicole Scholes-Robertson, Victoria Sinka, Rahim T. Vastani, Katherine Widders, Jacqueline Stephens, Allison Tong Kidney Int
  Indigenous Peoples are defined as those who first lived in a region and have distinct cultural traditions, knowledge and language which provides a basis for positive self-image and healthy identity.1 Indigenous Peoples have retained much of their cultural identity and displayed remarkable (...) (Kidney International (2022))
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  Spatially resolved transcriptomics and the kidney: Many opportunities - Eryn E. Dixon, Haojia Wu, Elizabeth Sulvarán-Guel, Juanru Guo, Benjamin D. Humphreys Kidney Int
  Abstract: Defining changes in gene expression during health and disease is critical for the understanding of human physiology. In recent years, single cell/nuclei RNA sequencing (sc/snRNAseq) has revolutionized the definition and discovery of cell types and states, as well as the interpretation (...) (Kidney International (2022))
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  The authors reply - Enric Vilar, Raja M. Kaja Kamal, James Fotheringham, Amanda Busby, Jocelyn Berdeprado, Ewa Kislowska, David Wellsted, Bassam Alchi, James O. Burton, Andrew Davenport, Ken Farrington Kidney Int
  We acknowledge the comments by Torreggiani et al.1 on our feasibility randomized controlled trial of incremental dialysis2 regarding the timing of initiating incremental dialysis. We randomized patients within 3 months of initiating hemodialysis rather than from day 1. The question is whether (...) (Kidney International 102, 1 (2022))
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  In this issue Kidney Int
  Fabry disease results from a deficiency of the enzyme galactosidase-A (GLA), leading to accumulation of its substrates, primarily globotriaosylceramide (GL3) in various cells, including podocytes. As the disease is X-linked, males are severely affected, and all podocytes have the Fabry (...) (Kidney International 102, 1 (2022))
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  Impact of APOL1 kidney risk variants on glomerular transcriptomes - Jeffrey B. Kopp, Jurgen Heymann Kidney Int
  McNulty and colleagues describe the glomerular transcriptional landscape of subjects with APOL1 (the gene encoding apolipoprotein L1)–associated kidney disease, using bulk RNA sequencing. They found the following: APOL1 gene expression was higher in individuals with APOL1 high-risk genetic (...) (Kidney International 102, 1 (2022))
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  Journal Club Kidney Int
  Hung et al. (JAMA Intern Med. 2022;182:386–395.) (Kidney International 102, 1 (2022))
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  Assessing prognosis in IgA nephropathy - Jürgen Floege, Stephanie Wied, Thomas Rauen Kidney Int
  Assessing the prognosis is essential in chronic diseases, such as IgA nephropathy. The 2021 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend the “International IgAN Prediction Tool” (available at www.qxmd.com) for this. The key limitation was that the tool was only validated (...) (Kidney International 102, 1 (2022))
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  Room for improvement: diagnosing and managing acute coronary syndromes in persons with reduced eGFR - Kerry L. Horne, Maarten W. Taal, Nicholas M. Selby Kidney Int
  Cardiovascular events are the leading cause of death in chronic kidney disease. A recent analysis from the High-Sensitivity Troponin in the Evaluation of Patients With Suspected Acute Coronary Syndrome trial focused on results in those with reduced estimated glomerular filtration rate. This (...) (Kidney International 102, 1 (2022))
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  James P. Knochel, MD, 1930–2022 Kidney Int
  The editorial board of Kidney International would like to express our heartfelt condolences to the family of Dr. James Knochel, who passed away on April 13, 2022, at the age of 91. Dr. Knochel served as an Associate Editor of Kidney International from 1984–2005. Dr. Knochel had a long and (...) (Kidney International 102, 1 (2022))
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  The proliferative and the antifibrotic side of PAX2 in tubular repair - Oliver Wessely, Stuart J. Shankland Kidney Int
  Regenerative repair following injury to proximal tubular epithelial cells (PTECs) is essential to restore the kidney to normal function in acute kidney injury. Failure to accomplish this leads to chronic kidney disease. Expression of the paired-box transcription factor Pax2 in PTECs is required (...) (Kidney International 102, 1 (2022))
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  A link between Krüppel-like factor 4, complement activation, and kidney damage - Diana Karpman, Sebastian Loos Kidney Int
  Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound (...) (Kidney International 102, 1 (2022))
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  Are randomized trials the best way to test different dialysis initiation regimens? - Massimo Torreggiani, Antioco Fois, Hafedh Fessi, Giorgina Barbara Piccoli Kidney Int
  We read with interest the randomized controlled trial by Vilar et al., who compared standard thrice-weekly hemodialysis (sHD) with twice weekly dialysis (iHD) in patients initiating maintenance hemodialysis (MHD).1 (Kidney International 102, 1 (2022))
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  Acute heart failure in a kidney transplant patient - Karim Jamhour-Chelh, María Melendo-Viu, David Dobarro, Sergio Raposeiras-Roubin, Inmaculada González-Bermúdez, Alberto Ortiz Sáez, Andrés Iñiguez-Romo Kidney Int
  A 62-year-old woman with a kidney transplant was admitted with a 3-week history of shortness of breath. On examination, she was noted to have a functioning upper limb arteriovenous fistula (AVF), enlargement of her left jugular vein (Figure 1a and b), decreased basal pulmonary breath sounds, (...) (Kidney International 102, 1 (2022))
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  Armanni-Ebstein lesion in a diabetic patient with acute tubular injury - Geetha Jagannathan, Vadim A. Finkielstein, Glen S. Markowitz, Satoru Kudose Kidney Int
  A 45-year-old White woman with recently diagnosed type 2 diabetes mellitus and hypertension presented with acute kidney injury and septic shock with gram-positive bacteremia from a toe wound. She was treated with vancomycin and piperacillin-tazobactam followed by ertapenem. She had no exposure (...) (Kidney International 102, 1 (2022))
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  Crystal-induced colitis - Andrea Spasiano, Federica Castri, Maria Cristina Giustiniani, Maria Elena Riccioni, Alessandro Naticchia, Giuseppe Grandaliano, Nicola Panocchia Kidney Int
  A 59-year-old man undergoing dialysis was admitted to our hospital with lower limb ischemia; he had a story of long-term use of phosphate and potassium chelator. Because of anemia and repeated episodes of bowel bleeding, he underwent colonoscopy with a biopsy of the ileocecal valve and (...) (Kidney International 102, 1 (2022))
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  The Case | Inflammatory polyarthritis in a kidney transplant recipient - Karthikeyan Manoharan, Priyansh Gupta, Hitaishi Mehta, Ritambhra Nada, Aravind Sekar, Ashwani Kumar, Aman Sharma, Manish Rathi, Harbir Singh Kohli, Keshavamurthy Vinay, Raja Ramachandran Kidney Int
  A 52-year-old man underwent live donor kidney transplantation for end-stage kidney disease in 2001 (20 years post-transplant). His maintenance immunosuppressive therapy was tacrolimus, azathioprine, and prednisolone. He had chronic allograft dysfunction (serum creatinine level of 3 mg/dl). (...) (Kidney International 102, 1 (2022))
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  Table of Contents Kidney Int
  (Kidney International 102, 1 (2022))
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  Subscription Information Kidney Int
  (Kidney International 102, 1 (2022))
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  Editorial Board Kidney Int
  (Kidney International 102, 1 (2022))
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  Erratum to Kudose S, Lipton M, Jain NG, D’Agati VD. “Valproic acid–associated proximal tubulopathy.” Kidney Int. 2022;101:653 Kidney Int
  In the above-stated article, the sentence “Next generation sequencing of the mitochondrial genome failed to detect any pathogenic variants.” was not included in the third paragraph of the article, after the description of Figure 1b. Here is the paragraph with the sentence (...) (Kidney International 102, 1 (2022))

29 June

Kidney Int http://www.kidney-international.org/

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  Kidney targeting of formoterol containing polymeric nanoparticles improves recovery from ischemia reperfusion-induced acute kidney injury in mice. - Ernest L. Vallorz, Jaroslav Janda, Heidi M. Mansour, Rick G. Schnellmann Kidney Int
  The ?2 adrenergic receptor agonist, formoterol, is an inducer of mitochondrial biogenesis and restorer of mitochondrial and kidney function in acute and chronic models of kidney injury. Unfortunately, systemic administration of formoterol has the potential for adverse cardiovascular effects, (...) (Kidney International (2022))
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  Podocyte-specific Nlrp3 inflammasome activation promotes diabetic kidney disease - Khurrum Shahzad, Sameen Fatima, Hamzah Khawaja, Ahmed Elwakiel, Ihsan Gadi, Saira Ambreen, Silke Zimmermann, Peter R. Mertens, Ronald Biemann, Berend Isermann Kidney Int
  Efficient therapies for diabetic kidney disease (DKD), now the leading cause of kidney failure, are lacking. One hallmark of DKD is sterile inflammation (inflammation in absence of microorganisms), but the underlying molecular mechanisms remain poorly understood. The NLRP3 inflammasome (innate (...) (Kidney International (2022))

27 June

Kidney Int http://www.kidney-international.org/

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  A nationwide Dutch cohort study shows relatively good pregnancy outcomes after kidney transplantation and finds risk factors for adverse outcomes - Margriet E. Gosselink, Marleen C. van Buren, Judith Kooiman, Henk Groen, Wessel Ganzevoort, Henk W. van Hamersvelt, Olivier W.H. van der Heijden, Jacqueline van de Wetering, Titia Lely Kidney Int
  Although numbers of pregnancy after kidney transplantation (KT) are rising, high risks of adverse pregnancy outcomes (APO) remain. Though important for pre-conception counselling and pregnancy monitoring, analyses of pregnancy outcomes after KT per pre-pregnancy estimated glomerular filtration (...) (Kidney International (2022))
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  The Dutch Childhood Cancer Survivor Study (DCCSS)-LATER 2 kidney analysis examined long-term glomerular dysfunction in childhood cancer survivors. - Esmee C.M. Kooijmans, Helena J.H. van der Pal, Saskia M.F. Pluijm, Margriet van der Heiden-van der Loo, Leontien C.M. Kremer, Dorine Bresters, Eline van Dulmen-den Broeder, Marry M. van den Heuvel-Eibrink, Jacqueline J. Loonen, Marloes Louwerens, Sebastian J.C. Neggers, Cécile Ronckers, Wim J.E. Tissing, Andrica C.H. de Vries, Gertjan J.L. Kaspers, Margreet A. Veening, Arend Bökenkamp, Dutch LATER study group Kidney Int
  This investigation aimed to evaluate glomerular dysfunction among childhood cancer survivors in comparison with matched controls from the general population. In the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER 2 kidney analysis, a nationwide cross-sectional cohort study, 1024 survivors (...) (Kidney International (2022))

24 June

Kidney Int http://www.kidney-international.org/

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  Vonoprazan-associated nephrotoxicity: extensive real-world evidence from spontaneous adverse drug reaction reports - Masayuki Ishida, Masami Tsuchiya, Junko Naito, Hitoshi Kawazoe, Daichi Watanabe, Yujiro Nonaka, Mika Sano, Hiroyasu Sakai, Akio Suzuki, Keisuke Kumada, Hiroyuki Okura, Masahito Shimizu, Hirotoshi Iihara Kidney Int
  Vonoprazan, a potassium-competitive acid blocker (P-CAB) possessing a new mechanism of action, was first approved in Japan in 2015 for the treatment of acid-related diseases. Vonoprazan inhibits acid secretion in the cells of the gastric wall. The inhibitory effect of vonoprazan on H+, (...) (Kidney International (2022))
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  Expression of active B-Raf proto-oncogene in kidney collecting ducts induces cyst formation in normal mice and accelerates cyst growth in mice with polycystic kidney disease. - Stephen C. Parnell, Archana Raman, Yan Zhang, Emily A. Daniel, Yuqiao Dai, Aditi Khanna, Gail A. Reif, Jay L. Vivian, Timothy A. Fields, Darren P. Wallace Kidney Int
  Polycystic kidney disease (PKD) is characterized by the formation and progressive enlargement of fluid-filled cysts due to abnormal cell proliferation. Cyclic AMP agonists, including arginine vasopressin, stimulate ERK-dependent proliferation of cystic cells, but not normal kidney cells. (...) (Kidney International (2022))
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  A tool for decision-making in kidney transplant candidates with poor prognosis to receive deceased donor transplantation in the United States. - Jesse D. Schold, Anne M. Huml, Emilio D. Poggio, Peter P. Reese, Sumit Mohan Kidney Int
  The primary outcomes for kidney transplant candidates are receipt of deceased or living donor transplant, death or removal from the waiting list. Here, we conducted a retrospective analysis of national Scientific Registry of Transplant Recipients data to evaluate outcomes for 208,717 adult (...) (Kidney International (2022))

22 June

Kidney Int http://www.kidney-international.org/

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  Results from a national-wide retrospective cohort measure the impact of C3 and soluble C5b-9 levels on kidney outcomes in C3 glomerulopathy. - Sophie Chauvet, Jill J. Hauer, Florent Petitprez, Marion Rabant, Paula Vieira Martins, Véronique Baudouin, Yahsou Delmas, Noémie Jourde-Chiche, Alexandre Cez, David Ribes, Sylvie Cloarec, Aude Servais, Mohamad Zaidan, Eric Daugas, Michel Delahousse, Alain Wynckel, Amélie Ryckewaert, Anne Laure Sellier-Leclerc, Olivia Boyer, Eric Thervet, Alexandre Karras, Richard J.H. Smith, Véronique Frémeaux-Bacchi Kidney Int
  C3 glomerulopathy (C3G) is a rare complement-mediated disease. Specific treatments are not yet available and factors predictive of kidney survival such as age, kidney function and proteinuria are not specific to C3G. The prognostic value of biomarkers of complement activation, which are (...) (Kidney International (2022))
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  Insulin-like growth factor binding protein 7 promotes acute kidney injury by alleviating poly ADP ribose polymerase 1 degradation. - Ju-tao Yu, Xiao-wei Hu, Qin Yang, Run-run Shan, Yao Zhang, Ze-hui Dong, Hai-di Li, Jia-nan Wang, Chao Li, Shuai-shuai Xie, Yu-hang Dong, Wei-jian Ni, Ling Jiang, Xue-qi Liu, Biao Wei, Jia-gen Wen, Ming-ming Liu, Qi Chen, Ya-ru Yang, Gui-yang Zhang, Hong-mei Zang, Juan Jin, Yong-gui Wu, Xiang Zhong, Jun Li, Wei Wang, Xiao-ming Meng Kidney Int
  The novel biomarker, insulin-like growth factor binding protein 7 (IGFBP7), is used clinically to predict different types of acute kidney injury (AKI) and has drawn significant attention as a urinary biomarker. However, as a secreted protein in the circulation of patients with AKI, it is (...) (Kidney International (2022))
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  Azithromycin use increases the risk of sudden cardiac death in patients with hemodialysis-dependent kidney failure. - Magdalene M. Assimon, Patrick H. Pun, Lily Wang, Sana M. Al-Khatib, M. Alan Brookhart, David J. Weber, Wolfgang C. Winkelmayer, Jennifer E. Flythe Kidney Int
  Azithromycin is an antibiotic with QT-prolonging potential commonly prescribed to individuals receiving hemodialysis. Hemodialysis patients have a high prevalence of clinical conditions, such as structural heart disease, that can enhance the pro-arrhythmic effects azithromycin, but were (...) (Kidney International (2022))

20 June

Kidney Int http://www.kidney-international.org/

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  Snapshots of nascent RNA can validate different nephron segment responses in acute kidney injury: a step toward clinically useful biomarkers? - Motonobu Nakamura, Masaomi Nangaku Kidney Int
  Acute kidney injury (AKI) is an organ damage syndrome that occurs in response to a variety of types of injury. Across a spectrum of clinical severity and pathologic damage, AKI is associated with poor prognosis. Tubular epithelial cells respond to injury and start the repair process within (...) (Kidney International (2022))
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  Modelling AKI in vitro: taking organoids to the next level - Letizia De Chiara, Yun Xia Kidney Int
  Repeated episodes of acute kidney injury (AKI) can lead to chronic kidney disease (CKD). The proximal tubule (PT) is particularly vulnerable to injury because it plays a crucial metabolic role in the handling of drugs, nephrotoxins, metabolites, and signaling molecules. Despite some (...) (Kidney International (2022))

17 June

Kidney Int http://www.kidney-international.org/

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  A retrospective cohort study measured predicting and validating the impact of the COVID-19 pandemic in individuals with chronic kidney disease - Ashkan Dashtban, Mehrdad A. Mizani, Spiros Denaxas, Dorothea Nitsch, Jennifer Quint, Richard Corbett, Jil B. Mamza, Tamsin Morris, Mamas Mamas, Deborah A. Lawlor, Kamlesh Khunti, CVD-COVID-UK Consortium, Cathie Sudlow, Harry Hemingway, Amitava Banerjee Kidney Int
  Chronic kidney disease (CKD) is associated with increased risk of baseline mortality and severe COVID-19, but analyses across CKD stages, and comorbidities are lacking. In prevalent and incident CKD, we investigated comorbidities, baseline risk, COVID-19 incidence, and predicted versus observed (...) (Kidney International (2022))

16 June

Kidney Int http://www.kidney-international.org/

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  Neutrophil gelatinase-associated lipocalin is elevated in children with acute kidney injury and sickle cell anemia, and predicts mortality - Anthony Batte, Sahit Menon, John M. Ssenkusu, Sarah Kiguli, Robert Kalyesubula, Joseph Lubega, Zachary Berrens, Edrisa Ibrahim Mutebi, Rodney Ogwang, Robert O. Opoka, Chandy C. John, Andrea L. Conroy Kidney Int
  Urine neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury that has been adapted to a urine dipstick test. However, there is limited data on its use in low-and-middle-income countries where diagnosis of acute kidney injury remains a challenge. To study this, (...) (Kidney International (2022))

15 June

Kidney Int http://www.kidney-international.org/

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  Proximal-tubule molecular relay from early Protein diaphanous homolog 1 to late Rho-associated protein kinase 1 regulates kidney function in obesity-induced kidney damage - Makiko Ida-Naitoh, Hirobumi Tokuyama, Koji Futatsugi, Marie Yasuda, Keika Adachi, Takeshi Kanda, Yoshiyuki Tanabe, Shu Wakino, Hiroshi Itoh Kidney Int
  The small GTPase protein RhoA has two effectors, ROCK (Rho-associated protein kinase 1) and mDIA1 (protein diaphanous homolog 1), which cooperate reciprocally. However, temporal regulation of RhoA and its effectors in obesity-induced kidney damage remains unclear. Here, we investigated the role (...) (Kidney International (2022))
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  A novel nanoluciferase transgenic reporter measures proteinuria in zebrafish - Richard W. Naylor, Emmanuel Lemarie, Anthony Jackson-Crawford, J. Bernard Davenport, Aleksandr Mironov, Martin Lowe, Rachel Lennon Kidney Int
  The zebrafish is an important animal system for modeling human diseases. This includes kidney dysfunction as the embryonic kidney (pronephros) shares considerable molecular and morphological homology with the human nephron. A key clinical indicator of kidney disease is proteinuria, but a (...) (Kidney International (2022))
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  A population cohort analysis of English transplant centers indicates major adverse cardiovascular events after kidney transplantation - Benjamin Anderson, Muhammad Qasim, Felicity Evison, Suzy Gallier, Jonathan N. Townend, Charles J. Ferro, Adnan Sharif Kidney Int
  Major adverse cardiovascular event (MACE) rates immediately after kidney transplantation remain uncertain due to heterogeneous reporting in the literature. To clarify this, we retrospectively studied every eligible kidney transplant procedure performed in England between April 1, 2002 and March (...) (Kidney International (2022))
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  Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies. - Mathias Gorski, Humaira Rasheed, Alexander Teumer, Laurent F. Thomas, Sarah E. Graham, Gardar Sveinbjornsson, Thomas W. Winkler, Felix Günther, Klaus J. Stark, Jin-Fang Chai, Bamidele O. Tayo, Matthias Wuttke, Yong Li, Adrienne Tin, Tarunveer S. Ahluwalia, Johan Ärnlöv, Bjørn Olav Åsvold, Stephan J.L. Bakker, Bernhard Banas, Nisha Bansal, Mary L. Biggs, Ginevra Biino, Michael Böhnke, Eric Boerwinkle, Erwin P. Bottinger, Hermann Brenner, Ben Brumpton, Robert J. Carroll, Layal Chaker, John Chalmers, Miao-Li Chee, Miao-Ling Chee, Ching-Yu Cheng, Audrey Y. Chu, Marina Ciullo, Massimiliano Cocca, (...) Kidney Int
  Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since (...) (Kidney International (2022))

8 June

Kidney Int http://www.kidney-international.org/

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  Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications - Maciej Tomaszewski, Andrew P. Morris, Joanna M. Howson, Nora Franceschini, James Eales, Xiaoguang Xu, Sergey Dikalov, Tomasz J. Guzik, Benjamin Humphreys, Stephen Harrap, Fadi J. Charchar Kidney Int
  Hypertension is a major cardiovascular disease risk factor and contributor to premature death globally. Family-based investigations confirmed a significant heritable component of blood pressure (BP), whereas genome-wide association studies revealed >1000 common and rare genetic variants (...) (Kidney International (2022))
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  The Case | A pregnant female with refractory hypocalcemia - Xin Yee Tan, Mary-Beth Roberts, Leila Z. Khan, John Stewart, Xiangling Wang Kidney Int
  A 25-year-old gravida 1 parity 0 female patient at 20 weeks of gestation was found to have asymptomatic hypocalcemia during her prenatal evaluation. Despite calcium and calcitriol supplementation for 4 months, her hypocalcemia persisted. The patient had no medical or surgical history, and there (...) (Kidney International (2022))

3 June

Kidney Int http://www.kidney-international.org/

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  Blood pressure adaptation in vertebrates: comparative biology - Akira Nishiyama, Kento Kitada, Miwa Suzuki Kidney Int
  With evolution from water to land, the osmotic regulation of body fluids and cardiovascular systems of vertebrates evolved to cope with dryness and gravity. While aquatic vertebrates can use buoyancy to compensate for the effects of gravity, terrestrial vertebrates cannot and must circulate (...) (Kidney International (2022))

2 June

Kidney Int http://www.kidney-international.org/

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  Molecular mechanisms and therapeutic targets for diabetic kidney disease - Katherine R. Tuttle, Rajiv Agarwal, Charles E. Alpers, George L. Bakris, Frank C. Brosius, Peter Kolkhof, Jaime Uribarri Kidney Int
  Diabetic kidney disease has a high global disease burden and substantially increases the risk of kidney failure and cardiovascular events. Despite treatment, there is substantial residual risk of disease progression with existing therapies. Therefore, there is an urgent need to better (...) (Kidney International (2022))

1 June

Kidney Int http://www.kidney-international.org/

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  Table of Contents Kidney Int
  (Kidney International 101, 6 (2022))
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  Subscription Information Kidney Int
  (Kidney International 101, 6 (2022))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 101, 6 (2022))
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  In this issue Kidney Int
  In this issue of Kidney International, we are pleased to introduce a new article series called Next Generation Clinical Pathologic Conference (CPC). These articles will merge the traditional CPC with molecular medicine for a fresh approach to decipher mechanisms of kidney disease. In (...) (Kidney International 101, 6 (2022))
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  JournalClub Kidney Int
  Rurik et al. (Science. 2022;375:91–96.) (Kidney International 101, 6 (2022))
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  Should we consider calcimimetics as a therapeutic option for nephrotic syndrome? - Olivia Lenoir, Pierre-Louis Tharaux Kidney Int
  Calcimimetics allosterically increase the calcium ion sensitivity of the calcium-sensing receptor (CaSR). Using a CaSR knockdown in podocytes and a podocyte-specific CaSR knockout in mice, Mühlig et al. uncovered a stabilizing role for actin cytoskeleton and cell adhesion. Short-term alleviation (...) (Kidney International 101, 6 (2022))
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  Renoprotection by GDF15 and Klotho: birds of a feather flock together - Hirotaka Komaba Kidney Int
  Growth differentiation factor 15 is a potential renoprotective factor whose expression is induced primarily at the proximal tubular site after kidney injury. Valiño-Rivas et al. confirmed the protective effect of growth differentiation factor 15 against different types of kidney injury and (...) (Kidney International 101, 6 (2022))
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  The authors reply - Johannes F.E. Mann, Alfred K. Cheung Kidney Int
  We thank Subbiah and Bhowmik1 for their comments. They point out that the Kidney Disease: Improving Global Outcomes recommendation2 focuses on the chronic kidney disease (CKD) subgroup of Systolic Blood Pressure Intervention Trial (SPRINT). That is because it is the best available evidence for (...) (Kidney International 101, 6 (2022))
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  KDIGO recommendations on blood pressure management in chronic kidney disease - Arunkumar Subbiah, Dipankar Bhowmik Kidney Int
  The “KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease” recommends a systolic blood pressure (BP) target (Kidney International 101, 6 (2022))
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  Corrigendum to Fang Y, Chen B, Gong AY, et al. “The ketone body ?-hydroxybutyrate mitigates the senescence response of glomerular podocytes to diabetic insults.” Kidney Int. 2021;100:1037–1053 Kidney Int
  The above-stated article contained an incorrect version of Figure 3 in which the representative micrograph of senescence-associated beta-galactosidase (SA-?-gal) staining in the ?-hydroxybutyrate (?-HB) group in Figure 3a was inadvertently used from the results of a different experiment (...) (Kidney International 101, 6 (2022))
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  Corrigendum to Gleeson S, Lightstone L. “BLISS-LN trial revisited: function matters.” Kidney Int. 2022;101:224–226 Kidney Int
  There are 3 corrections for the above-stated article. (Kidney International 101, 6 (2022))
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  Acute tubulointerstitial nephritis revealing VEXAS syndrome - Charles Ronsin, Laurent Benard, Amélie Mourtada, François Perrin, Zakaria Boukerroucha Kidney Int
  A new inflammatory disease characterized by somatic X-linked mutation of the UBA1 gene has been recently described in males and named “VEXAS syndrome,” an acronym for “Vacuoles, E1 enzyme, X linked, Autoinflammatory, Somatic syndrome.”1 Despite the fact that it affects the kidneys in up to 10% of (...) (Kidney International 101, 6 (2022))
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  Eculizumab impairs killing of Neisseria meningitidis serogroup B in atypical hemolytic uremic syndrome patients vaccinated with MenB-4C - Bryan van den Broek, Michiel van der Flier, Nicole C.A.J. van de Kar, Jack F.M. Wetzels, Marien I. de Jonge, Ronald de Groot, Kioa L. Wijnsma, Jeroen D. Langereis Kidney Int
  Recent reports suggest that eculizumab may not only compromise MenB-4C vaccination–induced serum killing of meningococci, but also opsonophagocytic killing.1,2 Using pre- and postvaccination serum from 5 patients with atypical hemolytic uremic syndrome (aHUS) on treatment with eculizumab and 2 (...) (Kidney International 101, 6 (2022))
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  Management of refractory lupus nephritis: rationale to consider tacrolimus - Durga Prasanna Misra, Vikas Agarwal Kidney Int
  We read with great interest the review article by Mejia-Vilet et al. about the management of lupus nephritis (LN).1 The authors mentioned that few uncontrolled studies had evaluated tacrolimus in combination with mycophenolate mofetil for LN.1 In a recent prospective observational study from (...) (Kidney International 101, 6 (2022))
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  Protective mechanisms harnessing against injurious heme and preventing kidney damage in STEC-HUS: toward new therapies? - Frank A.D.T.G. Wagener, Nicole C.A.J. van de Kar, Lambert P. van den Heuvel Kidney Int
  Hemolytic uremic syndrome can be initiated by Escherichia coli infections (Shiga-toxin–producing enterohemorrhagic Escherichia coli hemolytic uremic syndrome). When hemoglobin and heme released from ruptured erythrocytes interact with the kidney cells, this can result in platelet activation, (...) (Kidney International 101, 6 (2022))
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  The authors reply: - Robyn G. Langham, Ekamol Tantisattamo, Kamyar Kalantar-Zadeh, Siu-Fai Lui Kidney Int
  We appreciate Meyers for sharing a real-world perspective of caring for patients with kidney diseases in developing countries. The author also provided guidance for dealing with kidney diseases of these populations as a lower priority among other public health problems, including economic (...) (Kidney International 101, 6 (2022))
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  Kidney health literacy and public health economics - Anthony M. Meyers Kidney Int
  The authors of the special report promoting World Kidney Day must be congratulated on their article dealing with “Kidney Health for All” (the International Society of Nephrology [ISN]/International Federation of Kidney Foundations [IFKF] slogan).1 This most interesting and thought-provoking (...) (Kidney International 101, 6 (2022))
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  Renovascular hypertension secondary to massive iliopsoas hematoma - Ryunosuke Noda, Wei Han, Yugo Shibagaki, Masahiko Yazawa Kidney Int
  An 81-year-old woman with stage G3 chronic kidney disease status post left nephrectomy for upper tract urothelial carcinoma 20 years ago was admitted to our hospital for heart failure. She acutely developed right thigh pain, and contrast-enhanced computed tomography revealed an idiopathic (...) (Kidney International 101, 6 (2022))
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  Cerebral venous sinus thrombosis in nephrotic syndrome - Xinyi Gao, Yueming Liu, Qiang He, Xiaogang Shen Kidney Int
  A 36-year-old woman presented to the emergency department with recurrent syncope. She was diagnosed with nephrotic syndrome 16 days previously. Since she refused a kidney biopsy, she had been empirically treated with oral prednisone. A noncontrast computed tomography scan of the brain showed a (...) (Kidney International 101, 6 (2022))
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  A shining example of discolored dialysate - Kate Drummond, Matthew Davies Kidney Int
  A 56-year-old patient on home hemodialysis noticed a yellow discoloration to the effluent fluid in his dialyzer and tubing (Figure 1a) shortly after commencing dialysis. Dialysis was ceased and a dialysate sample collected. Medical history included autosomal dominant polycystic kidney disease, (...) (Kidney International 101, 6 (2022))
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  The Case | Late allograft dysfunction with unexpected biopsy findings - Ibrahim Batal, Heather K. Morris Kidney Int
  A 63-year-old man with end-stage kidney disease secondary to atrophic right kidney and type 2 diabetes mellitus received a living-related kidney allograft from his sister. Induction therapy included thymoglobulin, and maintenance immunosuppression consisted of tacrolimus and mycophenolate (...) (Kidney International 101, 6 (2022))

31 May

Kidney Int http://www.kidney-international.org/

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  GSK? as a target in podocyte aging - Stuart J. Shankland, Oliver Wessely Kidney Int
  Increasing evidence highlights the importance of studying kidney aging. The global population is aging. It is estimated that by 2060 the number of Americans 65 years and older will double; similarly, 28% of Europeans will be over 65 years of age. The risk, incidence, and prevalence of chronic (...) (Kidney International (2022))

30 May

Kidney Int http://www.kidney-international.org/

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  Caloric restriction reduces the pro-inflammatory eicosanoid 20-hydroxyeicosatetraenoic acid to protect from acute kidney injury - Karla Johanna Ruth Hoyer-Allo, Martin Richard Späth, Susanne Brodesser, Yiyi Zhu, Julia Binz-Lotter, Martin Höhne, Hella Broenneke, Katrin Bohl, Marc Johnsen, Torsten Kubacki, Katharina Kiefer, Lisa Seufert, Felix Carlo Koehler, Franziska Grundmann, Matthias J. Hackl, Bernhard Schermer, Jens Brüning, Thomas Benzing, Volker Burst, Roman-Ulrich Müller Kidney Int
  Acute kidney injury is a frequent complication in the clinical setting and associated with significant morbidity and mortality. Preconditioning with short-term caloric restriction is highly protective against kidney injury in rodent ischemia reperfusion injury models. However, the underlying (...) (Kidney International (2022))

27 May

Kidney Int http://www.kidney-international.org/

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  Defective KIM-1 phagocytosis does not predispose to acute graft dysfunction after kidney transplantation in humans - Rita S. Suri, Ji Yun Lee, Matthew R. Ban, Bradly Shrum, Elena Tutunea-Fatan, Ola Z. Ismail, Stephen H. Leckie, Adam D. McIntyre, Qingyong Xu, Seung Ho Lee, Sonali N. de Chickera, Robert A. Hegele, Lakshman Gunaratnam Kidney Int
  Ischemia-reperfusion injury (IRI) is common to several pathologic conditions, including myocardial infarction, stroke, acute kidney injury, and delayed graft function after kidney transplantation.1 Clearance of apoptotic and necrotic cells by resident immune or epithelial cellsS1,S2 prevents (...) (Kidney International (2022))

26 May

Kidney Int http://www.kidney-international.org/

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  Preemptive simultaneous pancreas kidney transplantation has survival benefit to patients - Enrique Montagud-Marrahi, Elena Cuadrado-Payán, Evelyn Hermida, Judit Cacho, David Cucchiari, Ignacio Revuelta, Jimena del Risco-Zevallos, Nuria Esforzado, Frederic Cofan, Federic Oppenheimer, Vicens Torregrosa, Joana Ferrer, Antoni J. Amor, Enric Esmatjes, Maria José Ramírez-Bajo, Mireia Musquera, Mathew Cooper, Beatriu Bayes, Josep M. Campistol, Fritz Diekmann, Pedro Ventura-Aguiar Kidney Int
  Several organ allocation protocols give priority to wait-listed simultaneous kidney-pancreas (SPK) transplant recipients to mitigate the higher cardiovascular risk of patients with diabetes mellitus on dialysis. The available information regarding the impact of preemptive simultaneous (...) (Kidney International (2022))
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  Ttc21b deficiency attenuates autosomal dominant polycystic kidney disease in a kidney tubular- and maturation-dependent manner - Wei Wang, Luciane M. Silva, Henry H. Wang, Matthew A. Kavanaugh, Tana S. Pottorf, Bailey A. Allard, Damon T. Jacobs, Rouchen Dong, Joseph T. Cornelius, Aakriti Chaturvedi, Katherine I. Swenson-Fields, Timothy A. Fields, Michele T. Pritchard, Madhulika Sharma, Chad Slawson, Darren P. Wallace, James P. Calvet, Pamela V. Tran Kidney Int
  Primary cilia are sensory organelles built and maintained by intraflagellar transport (IFT) multiprotein complexes. Deletion of several IFT-B genes attenuates polycystic kidney disease (PKD) severity in juvenile and adult autosomal dominant polycystic kidney disease (ADPKD) mouse models. (...) (Kidney International (2022))
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  Klotho-derived peptide 6 ameliorates diabetic kidney disease by targeting Wnt/?-catenin signaling - Xiaowen Chen, Huishi Tan, Jie Xu, Yuan Tian, Qian Yuan, Yangyang Zuo, Qiyan Chen, Xue Hong, Haiyan Fu, Fan Fan Hou, Lili Zhou, Youhua Liu Kidney Int
  Diabetic kidney disease (DKD) is one of the most common and devastating complications of diabetic mellitus, and its prevalence is rising worldwide. Klotho, an anti-aging protein, is kidney protective in DKD. However, its large size, prohibitive cost and structural complexity hamper its (...) (Kidney International (2022))
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  Lineage tracing analysis defines erythropoietin-producing cells as a distinct subpopulation of resident fibroblasts with unique behaviors - Keiichi Kaneko, Yuki Sato, Eiichiro Uchino, Naoya Toriu, Mayo Shigeta, Hiroshi Kiyonari, Shuichiro Endo, Shingo Fukuma, Motoko Yanagita Kidney Int
  Erythropoietin (Epo) is produced by a subpopulation of resident fibroblasts in the healthy kidney. We have previously demonstrated that, during kidney fibrosis, kidney fibroblasts including Epo-producing cells transdifferentiate into myofibroblasts and lose their Epo-producing ability. However, (...) (Kidney International (2022))
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  Naturally occurring stable calcium isotope ratios are a novel biomarker of bone calcium balance in chronic kidney disease - Rukshana Shroff, Alexander D. Lalayiannis, Mary Fewtrell, Claus Peter Schmitt, Aysun Bayazit, Varvara Askiti, Augustina Jankauskiene, Justine Bacchetta, Selmy Silva, Nadine Goodman, Louise McAlister, Lorenzo Biassoni, Nicola Crabtree, Anja Rahn, Dagmar-Christiane Fischer, Alexander Heuser, Ana Kolevica, Anton Eisenhauer Kidney Int
  Dysregulated calcium homeostasis is common in chronic kidney disease and causally associated with disorders of bone mineralization. However, radiological measures and biomarkers do not allow accurate evaluation of bone calcium balance. Non-radioactive calcium isotopes, 42Ca and 44Ca, are (...) (Kidney International (2022))

25 May

Kidney Int http://www.kidney-international.org/

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  Oral Coenzyme Q10 supplementation leads to better preservation of kidney function in steroid-resistant nephrotic syndrome due to primary Coenzyme Q10 deficiency - Stefania Drovandi, Beata S. Lipska-Zi?tkiewicz, Fatih Ozaltin, Francesco Emma, Bora Gulhan, Olivia Boyer, Agnes Trautmann, Hong Xu, Qian Shen, Jia Rao, Korbinian M. Riedhammer, Uwe Heemann, Julia Hoefele, Sarah L. Stenton, Alexey N. Tsygin, Kar-Hui Ng, Svitlana Fomina, Elisa Benetti, Manon Aurelle, Larisa Prikhodina, Michiel F. Schreuder, Mansoureh Tabatabaeifar, Maciej Jankowski, Sergey Baiko, Jianhua Mao, Chunyue Feng, Cuihua Liu, Shuzhen Sun, Fang Deng, Xiaowen Wang, Stéphanie Clavé, Ma?gorzata Sta?czyk, Irena Ba?asz-Chmielewska, Marc Fila, Anne M. Durkan, Tanja Kersnik Levart, Ismail (...) Kidney Int
  Primary Coenzyme Q10 (CoQ10) deficiency is an ultra-rare disorder caused by defects in genes involved in CoQ10 biosynthesis leading to multidrug-resistant nephrotic syndrome as the hallmark kidney manifestation. Promising early results have been reported anecdotally with oral CoQ10 (...) (Kidney International (2022))
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  Bone histomorphometry for the diagnosis of renal osteodystrophy: a call for harmonization of reference ranges - Hanne Skou Jørgensen, Ana Carina Ferreira, Patrick D’Haese, Mathias Haarhaus, Marc Vervloet, Marie-Helene Lafage-Proust, Anibal Ferreira, Pieter Evenepoel, European Renal Osteodystrophy (EUROD) workgroup, Chronic Kidney Disease - Mineral and Bone Disorder Working Group (CKD-MBD WG) Kidney Int
  A bone biopsy of the anterior iliac crest is the gold standard for the evaluation of bone disease in chronic kidney disease. The bone histomorphometric analysis consists of a detailed description of bone histology, including skeletal remodeling, bone mineralization, and bone microarchitecture. (...) (Kidney International (2022))
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  Diverse molecular causes of unsolved autosomal dominant tubulointerstitial kidney diseases - Florian J. Wopperer, Karl X. Knaup, Kira J. Stanzick, Karen Schneider, Tilman Jobst-Schwan, Arif B. Ekici, Steffen Uebe, Andrea Wenzel, Stefan Schliep, Carsten Schürfeld, Randolf Seitz, Wanja Bernhardt, Markus Gödel, Antje Wiesener, Bernt Popp, Klaus J. Stark, Hermann-Josef Gröne, Björn Friedrich, Martin Weiß, Nikolina Basic-Jukic, Mario Schiffer, Bernd Schröppel, Bruno Huettel, Bodo B. Beck, Genomics England Research Consortium, John A. Sayer, Christine Ziegler, Maike Büttner-Herold, Kerstin Amann, Iris M. Heid, André Reis, Francesca Pasutto, Michael S. (...) Kidney Int
  Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD) is caused by mutations in one of at least five genes and leads to kidney failure usually in mid adulthood. Throughout the literature, variable numbers of families have been reported, where no mutation can be found and therefore termed (...) (Kidney International (2022))
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  Daprodustat prevents cyclosporine-A mediated anemia and peritubular capillary loss - Robert Labes, Lennart Brinkmann, Vera A. Kulow, Kameliya Roegner, Susanne Mathia, Björn Balcerek, Pontus B. Persson, Christian Rosenberger, Michael Fähling Kidney Int
  Chronic Cyclosporine-A treatment is associated with serious side effects, including kidney toxicity and anemia. Although pathophysiology of Cyclosporine-A-induced kidney injury remains incompletely understood, hypoxia is likely involved. Here, we investigated the effect of the hypoxia inducible (...) (Kidney International (2022))

24 May

Kidney Int http://www.kidney-international.org/

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  Myeloid-derived Growth Factor Deficiency Exacerbates Mitotic Catastrophe of Podocytes in Glomerular Disease - Ping Zhan, Yang Zhang, Weichen Shi, Xiaohan Liu, Zhe Qiao, Ziying Wang, Xiaojie Wang, Jichao Wu, Wei Tang, Yu Sun, Yan Zhang, Junhui Zhen, Jin Shang, Min Liu, Fan Yi Kidney Int
  Podocytes are unique, highly specialized, terminally differentiated cells, which are restricted in a post-mitotic state with limited ability to repair or regenerate. Re-entering the mitotic phase causes podocyte mitotic catastrophe, thereby leading to podocyte death and glomerular injury. (...) (Kidney International (2022))

23 May

Kidney Int http://www.kidney-international.org/

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  Pre-exposure prophylaxis with 300 mg Evusheld elicits limited neutralizing activity against the Omicron variant - Ilies Benotmane, Aurélie Velay, Gabriela Gautier-Vargas, Jérôme Olagne, Olivier Thaunat, Samira Fafi-Kremer, Sophie Caillard Kidney Int
  Immunocompromised patients show an impaired vaccine-induced immune response, resulting in an increased risk of severe coronavirus disease 2019 (COVID-19).1 In an effort to address this issue, health authorities in the US and various European countries have subsequently authorized the use of (...) (Kidney International (2022))
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  Efficacy of anti–SARS-CoV-2 monoclonal antibody prophylaxis and vaccination on the Omicron variant of COVID-19 in kidney transplant recipients - Dominique Bertrand, Charlotte Laurent, Veronique Lemée, Ludivine Lebourg, Mélanie Hanoy, Frank Le Roy, Dorian Nezam, Diana Pruteanu, Steven Grange, Tristan de Nattes, Mathilde Lemoine, Sophie Candon, Dominique Guerrot Kidney Int
  Solid organ transplantation (SOT) recipients are at very high risk of developing severe coronavirus disease 2019 (COVID-19).1 Despite the implementation of a third dose of mRNA vaccine, the efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination on humoral and (...) (Kidney International (2022))
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  Use of renin angiotensin aldosterone system inhibitors in children with lupus and time to glucocorticoid discontinuation - Joyce C. Chang, Pamela F. Weiss, Rui Xiao, Meredith A. Atkinson, Scott E. Wenderfer Kidney Int
  There is little data to inform use of renin angiotensin aldosterone system (RAAS) inhibitors in pediatric patients with systemic lupus erythematosus (SLE). Here, we sought to characterize RAAS inhibitor use in pediatric SLE and determine whether early RAAS inhibitor initiation among children (...) (Kidney International (2022))
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  Results of untargeted analysis using the SOMAscan proteomics platform indicates novel associations of circulating proteins with risk of progression to kidney failure in diabetes - Hiroki Kobayashi, Helen C. Looker, Eiichiro Satake, Pierre Jean Saulnier, Zaipul I. Md Dom, Kristina O’Neil, Katsuhito Ihara, Bozena Krolewski, Andrzej T. Galecki, Monika A. Niewczas, Jonathan M. Wilson, Alessandro Doria, Kevin L. Duffin, Robert G. Nelson, Andrzej S. Krolewski Kidney Int
  This study applies a large proteomics panel to search for new circulating biomarkers associated with progression to kidney failure in individuals with diabetic kidney disease. Four independent cohorts encompassing 754 individuals with type 1 and type 2 diabetes and early and late diabetic (...) (Kidney International (2022))

19 May

Kidney Int http://www.kidney-international.org/

• 00:00
  Bruceine A protects against diabetic kidney disease via inhibiting galectin-1 - Huiying Li, Xiaoli Zhao, Liyun Zheng, Xiukun Wang, Shuai Lin, Jiajia Shen, Hangjiang Ren, Yi Li, Qiang Qiu, Zhen Wang Kidney Int
  Bruceine A is a natural quassinoid compound extracted from the fruit of the Traditional Chinese Medicine Brucea javanica (L.) Merr. that has various types of various biological activities. However, whether the compound has a protective effect on diabetic kidney disease remains unknown. (...) (Kidney International (2022))

18 May

Kidney Int http://www.kidney-international.org/

• 00:00
  Rho-associated, coiled-coil–containing protein kinase 1 regulates development of diabetic kidney disease via modulation of fatty acid metabolism - Yosuke Nagai, Keiichiro Matoba, Yusuke Takeda, Hideji Yako, Tomoyo Akamine, Kensuke Sekiguchi, Yasushi Kanazawa, Tamotsu Yokota, Kazunori Sango, Daiji Kawanami, Kazunori Utsunomiya, Rimei Nishimura Kidney Int
  Dysregulation of fatty acid utilization is increasingly recognized as a significant component of diabetic kidney disease. Rho-associated, coiled-coil–containing protein kinase (ROCK) is activated in the diabetic kidney, and studies over the past decade have illuminated ROCK signaling as an (...) (Kidney International (2022))

14 May

Kidney Int http://www.kidney-international.org/

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  Inferior cellular and humoral immunity against Omicron and Delta variants of concern compared with SARS-CoV-2 wild type in hemodialysis patients immunized with 4 SARS-CoV-2 vaccine doses - Moritz Anft, Arturo Blazquez-Navarro, Michael Frahnert, Lutz Fricke, Toni L. Meister, Toralf Roch, Ulrik Stervbo, Stephanie Pfaender, Timm H. Westhoff, Nina Babel Kidney Int
  With the dominance of the most recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern Omicron (B.1.1.529), the question arises, what is the reason for its high contagiousness in coronavirus disease 2019 (COVID-19)–vaccinated dialysis patients compared with the (...) (Kidney International 102, 1 (2022))

5 May

Kidney Int http://www.kidney-international.org/

• 00:00
  Biological pathways and comparison with biopsy signals and cellular origin of peripheral blood transcriptomic profiles during kidney allograft pathology - Elisabet Van Loon, Baptiste Lamarthée, Henriette de Loor, Amaryllis H. Van Craenenbroeck, Sophie Brouard, Richard Danger, Magali Giral, Jasper Callemeyn, Claire Tinel, Álvaro Cortés Calabuig, Priyanka Koshy, Ben Sprangers, Dirk Kuypers, Wilfried Gwinner, Dany Anglicheau, Pierre Marquet, Maarten Naesens Kidney Int
  Kidney transplant injury processes are associated with molecular changes in kidney tissue, primarily related to immune cell activation and infiltration. How these processes are reflected in the circulating immune cells, whose activation is targeted by strong immunosuppressants, is poorly (...) (Kidney International 102, 1 (2022))

2 May

Kidney Int http://www.kidney-international.org/

• 00:00
  Clinicopathological characteristics of high-altitude polycythemia-related kidney disease in Tibetan inhabitants - Hui Wang, Chen Tang, Zonghui Dang, A Yong, Lijun Liu, Suxia Wang, Minghui Zhao Kidney Int
  High-altitude polycythemia (HAPC) is a clinical syndrome that occurs in native inhabitants or long-term residents living at altitude. The kidney is one of the most affected organs. However, the clinical and kidney histopathological profiles of HAPC-related kidney disease have rarely been (...) (Kidney International 102, 1 (2022))
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  Soluble ?-klotho and heparin modulate the pathologic cardiac actions of fibroblast growth factor 23 in chronic kidney disease - Christopher Yanucil, Dominik Kentrup, Isaac Campos, Brian Czaya, Kylie Heitman, David Westbrook, Gunars Osis, Alexander Grabner, Adam R. Wende, Julian Vallejo, Michael J. Wacker, Jose Alberto Navarro-Garcia, Gema Ruiz-Hurtado, Fuming Zhang, Yuefan Song, Robert J. Linhardt, Kenneth White, Michael S. Kapiloff, Christian Faul Kidney Int
  Fibroblast growth factor (FGF) 23 is a phosphate-regulating hormone that is elevated in patients with chronic kidney disease and associated with cardiovascular mortality. Experimental studies showed that elevated FGF23 levels induce cardiac hypertrophy by targeting cardiac myocytes via FGF (...) (Kidney International (2022))
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  Susceptibility to kidney fibrosis in mice is associated with early growth response-2 protein and tissue inhibitor of metalloproteinase-1 expression - Gábor Kökény, Ágnes Németh, Jeffrey B. Kopp, Weiping Chen, Andrew J. Oler, Anna Manzéger, László Rosivall, Miklós M. Mózes Kidney Int
  Patients with chronic kidney disease and experimental animal models of kidney fibrosis manifest diverse progression rates. Genetic susceptibility may contribute to this diversity, but the causes remain largely unknown. We have previously described kidney fibrosis with a mild or severe phenotype (...) (Kidney International (2022))
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  The characteristics of seronegative and seropositive non-hepatitis-associated cryoglobulinemic glomerulonephritis - Vincent Javaugue, Anthony M. Valeri, Insara Jaffer Sathick, Samar M. Said, Sibel Erdogan Damgard, David L. Murray, Tyler Klobucher, Nicole K. Andeen, Sanjeev Sethi, Fernando C. Fervenza, Nelson Leung, Samih H. Nasr Kidney Int
  The clinicopathologic characteristics and long-term outcome of non-hepatitis-associated cryoglobulinemic glomerulonephritis (CryoGN) are not well-defined and cases with undetectable serum cryoglobulin (seronegative CryoGN) have not been investigated.To resolve this, we retrospectively (...) (Kidney International (2022))

1 May

Kidney Int http://www.kidney-international.org/

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  A challenge to the kidney community by a man-made crisis - P. Toby Coates, Germaine Wong, Brad H. Rovin, Pierre Ronco, Entire Editorial and Management Team Kidney Int
  “No man is an island,Entire of itself,Each is a part of the continent,A part of the main,If a clod be washed away by sea,Europe is the less,As well as if a promontory were”John Donne, For Whom the Bell Tolls, 1572–1631 (Kidney International 101, 5 (2022))
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  Table of Contents Kidney Int
  (Kidney International 101, 5 (2022))
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  Subscription Information Kidney Int
  (Kidney International 101, 5 (2022))
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  Editorial Board Kidney Int
  (Kidney International 101, 5 (2022))
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  In This Issue Kidney Int
  Anti–brush border antibody disease (ABBA) is a rare, progressive kidney disease that has, until now, been characterized only by autoantibodies against megalin. Morelle et al. identified a patient with ABBA by histology, but without anti-megalin antibodies. Using proteomics to identify the (...) (Kidney International 101, 5 (2022))
• 00:00
  Journal Club Kidney Int
  Wu et al. (J Clin Invest. 2021;131:e136329.) (Kidney International 101, 5 (2022))
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  Tribute to Jan Weening (1950–2022) - John H. Dirks, Sandrine Florquin, Pierre Ronco Kidney Int
  Jan J. Weening, Professor of Pathology, University of Amsterdam, died of a sudden cerebral hemorrhage on January 31, 2022, at his home in Hilversum, the Netherlands—he was just 3 months short of the age of 72 years. He was a former President of the International Society of Nephrology (ISN) and a (...) (Kidney International 101, 5 (2022))
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  The authors reply: - Lena Berchtold, Sophie de Seigneux, Jean-Paul Vallée Kidney Int
  We appreciate the interest of Inoue et al. in our article exploring the use of diffusion-magnetic resonance imaging to predict the decline of kidney function in chronic kidney disease and in patients with a kidney allograft.1 (Kidney International 101, 5 (2022))
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  In memoriam: Charles van Ypersele de Strihou (1933–2021) - Yves Pirson, Olivier Devuyst Kidney Int
  Charles van Ypersele de Strihou, a precursor and early leader of European nephrology, died peacefully at home on Tuesday, December 7, 2021, at the age of 88 years. He was Professor Emeritus of Nephrology at the Catholic University of Louvain Medical School in Brussels, Belgium. van Ypersele was (...) (Kidney International 101, 5 (2022))
• 00:00
  Regulation of T- and B-cell interactions determines the clinical phenotype associated with donor-specific antibodies - Sumoyee Basu, Anthony Dorling Kidney Int
  The cellular mechanisms that regulate donor-specific antibody formation and antibody-mediated rejection remain unknown. In this issue, Louis et al. report that specific T-regulatory cell and B-regulatory transitional cell subsets are concomitantly diminished in patients with donor-specific (...) (Kidney International 101, 5 (2022))
• 00:00
  The authors reply: - Verônica T. Costa e Silva, Lesley A. Inker, Emmanuel A. Burdmann, Andrew S. Levey Kidney Int
  As described in their letter, Iversen et al.1 assessed the performance of equations for estimated glomerular filtration rate (eGFR) using serum creatinine (eGFRcr), serum cystatin C (eGFRcys), or both (eGFRcr-cys) in 110 older medical Danish patients in the emergency department compared to (...) (Kidney International 101, 5 (2022))
• 00:00
  Performance of the Cockcroft-Gault, Modification of Diet in Renal Disease, and new Chronic Kidney Disease Epidemiology Collaboration equations without race in older acute medical patients - Esben Iversen, Anne Kathrine Bengaard, Aino Andersen, Thomas Kallemose, Morten Damgaard, Mads Hornum, Bo Feldt-Rasmussen, Ove Andersen, Morten Baltzer Houlind Kidney Int
  Costa e Silva et al. compare the performance of equations for estimated glomerular filtration rate (GFR) in patients with cancer and conclude that the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations should be preferred over the Cockcroft-Gault equation.1 We have previously (...) (Kidney International 101, 5 (2022))
• 00:00
  The relationship between imaging features of diffusion-weighted imaging and prognosis of chronic kidney disease - Tsutomu Inoue, Eito Kozawa, Masahiro Ishikawa, Naoki Kobayashi, Hirokazu Okada Kidney Int
  Berchtold et al. reported that corticomedullary differentiation (CMD) abnormality in the apparent diffusion coefficient (ADC) for diffusion-weighted magnetic resonance (MR) imaging affords an index that is significantly correlated with prognosis in chronic kidney disease.1 We express our (...) (Kidney International 101, 5 (2022))
• 00:00
  Metformin versus SGLT-2 inhibitors: how low can we go? - Menno Pruijm, Olivier Phan, Anne Zanchi Kidney Int
  The progression of chronic kidney disease is difficult to stop once established. Metformin and sodium-glucose cotransporter 2 inhibitors show promise, but clinical trials with a head-to-head comparison in patients with more advanced (stage 3b–4) chronic kidney disease are largely lacking, partly (...) (Kidney International 101, 5 (2022))
• 00:00
  Virus-related collapsing glomerulopathy, a common mechanism of injury? - Joseph P. Gaut Kidney Int
  Collapsing glomerulopathy frequently shows focal lesions on biopsy, creating challenges with transcriptomic investigations because of inadequate tissue sample. This challenge is overcome with spatial transcriptomics, technology linking transcriptomic data to histology. Applying this technology (...) (Kidney International 101, 5 (2022))
• 00:00
  Mitochondrial pharmacotherapy during pregnancy and lactation in an ADPKD mouse model: a win for both mothers and their offspring - Wei Wang, Pamela V. Tran Kidney Int
  Pharmacotherapies that are safe during pregnancy are lacking for patients with autosomal dominant polycystic kidney disease. In this issue, Daneshgar et al. reveal that administration of the mitochondrial-protective peptide, elamipretide, during pregnancy and lactation in a mouse model with (...) (Kidney International 101, 5 (2022))
• 00:00
  The authors reply: - Frank Bridoux, Nelson Leung, Jean Paul Fermand Kidney Int
  We read with interest the letter by Shulman et al.1 questioning our recommendation on the use of pamidronate over zoledronic acid (ZA) in patients with myeloma light chain cast nephropathy.2 (Kidney International 101, 5 (2022))
• 00:00
  Pamidronate versus zoledronic acid for the treatment of multiple myeloma–related hypercalcemia - Rachel Shulman, Abdallah S. Geara, Jeffrey S. Berns Kidney Int
  The recent review by Bridoux et al.,1 in Kidney International, on the management of acute kidney injury in multiple myeloma states that pamidronate is preferred to zoledronic acid (ZA) for treating hypercalcemia in multiple myeloma due to lower risk of kidney complications. We do not believe (...) (Kidney International 101, 5 (2022))
• 00:00
  Lay A TRAP for myeloid cell response in diabetic kidney disease - Hiroshi Nishi Kidney Int
  The functions of the renin-angiotensin system are crucial in the progression of diabetic kidney disease. ATRAP is a type 1 angiotensin II receptor–associated protein that negatively regulates intracellular angiotensin II signaling. In this issue, Haruhara et al. revealed that ATRAP deficiency of (...) (Kidney International 101, 5 (2022))
• 00:00
  The authors reply: - Raphael J. Rosen, Hilda E. Fernandez, Shayan Shirazian, Andrew A. Moses Kidney Int
  Yang et al.1 assert that medial calcification in the subcutaneous arterioles is the gold standard for diagnosis of calciphylaxis. These arterioles are typically 40–600 ?m, and the smallest resolution that the linear array transducer (the probe with the best spatial resolution that is in regular (...) (Kidney International 101, 5 (2022))
• 00:00
  Comments on “Ultrasound findings of calciphylaxis” - Canlin Yang, Xiaoliang Zhang, Xiaotong Xie, Yu Zhao Kidney Int
  A recently published nephrology image uses noninvasive ultrasound to diagnose calciphylaxis,1 which is a valuable attempt. However, considering the specificity of the diagnosis of calciphylaxis and the complexity of its comorbidities, we think there are several controversies in this (...) (Kidney International 101, 5 (2022))
• 00:00
  The authors reply: - Pan Yu, Raymond C. Harris, Ming-Zhi Zhang Kidney Int
  We appreciate Professor Cravedi’s interest1 in our recent study2 and the helpful suggestions for our future research. CD11b+Ly6clow monocytes, also known as nonclassical monocytes or patrolling monocytes, have received considerable attention in recent years because they may be associated with (...) (Kidney International 101, 5 (2022))
• 00:00
  Role of cyclooxygenase-2 in macrophage subsets during kidney repair - Paolo Cravedi Kidney Int
  We congratulate Pan et al. for their beautiful study published in Kidney International.1 The work indicates that the cyclooxygenase-2 pathway in myeloid cells is a critical mediator of the balance between tissue injury and repair following acute kidney injury (AKI). The elegantly designed (...) (Kidney International 101, 5 (2022))
• 00:00
  Pouch of Douglas hernia in a patient on peritoneal dialysis - Meng-qin Zhang, Xiao-yu Jia, Zhi-kai Yang, Tian-tian Ma, Yu-feng Xu, Ye Lu, Jie Dong Kidney Int
  A 59-year-old woman on continuous ambulatory peritoneal dialysis presented to our center with the complaint of her swollen hip and intermittent vaginal discharge for 2 years. She developed those symptoms after a sudden heave and long squat. These symptoms became worse when she stood or walked (...) (Kidney International 101, 5 (2022))
• 00:00
  Doxorubicin-associated red-colored dialysate - Chia-Ling Helen Wei, Ding-Jie Lee, Chia-Chao Wu Kidney Int
  A 46-year-old woman with a history of hypertensive cardiovascular disease and end-stage kidney disease on continuous ambulatory peritoneal dialysis for 8 years was first evaluated for red-colored dialysate. Her recent history included an incidentally discovered mass in her left lower abdomen (...) (Kidney International 101, 5 (2022))
• 00:00
  Rapid regression of uremic calcinosis - Tomasz Ho?ub, Marta Jagodzi?ska, Agnieszka Makówka, Kamila K?dzierska, Micha? Nowicki Kidney Int
  A 28-year-old man with end-stage kidney disease from posterior urethral valve undergoing peritoneal dialysis for 3.5 years, presented with pain and swelling of both shoulders. Computed tomography revealed numerous massive calcifications in the subcutaneous tissue around both shoulder joints (...) (Kidney International 101, 5 (2022))
• 00:00
  The Case | A rare donor-derived cause of delayed graft function - Himabindu Yerneni, Miroslav Sekulic, Praveen Gundelly, Nagaraju Sarabu Kidney Int
  A 52-year-old African American man presented to the office with abdominal pain over his kidney allograft and ongoing anuria, 1 week after a deceased donor transplant. He was discharged from hospital 2 days before presentation. His medical history was notable for end-stage kidney disease (...) (Kidney International 101, 5 (2022))

28 April

Kidney Int http://www.kidney-international.org/

• 00:00
  Application of the International IgA Nephropathy Prediction Tool one or two years post-biopsy - Sean J. Barbour, Rosanna Coppo, Hong Zhang, Zhi-Hong Liu, Yusuke Suzuki, Keiichi Matsuzaki, Lee Er, Heather N. Reich, Jonathan Barratt, Daniel C. Cattran, International IgA Nephropathy Network Kidney Int
  The International IgA Nephropathy (IgAN) Prediction Tool is the preferred method in the 2021 KDIGO guidelines to predict, at the time of kidney biopsy, the risk of a 50% drop in estimated glomerular filtration rate or kidney failure. However, it is not known if the Prediction Tool can be (...) (Kidney International 102, 1 (2022))

25 April

Kidney Int http://www.kidney-international.org/

• 00:00
  Blocking ribosomal protein S6 phosphorylation inhibits podocyte hypertrophy and focal segmental glomerulosclerosis - Fang Li, Yili Fang, Qiyuan Zhuang, Meichu Cheng, Desmond Moronge, Hao Jue, Oded Meyuhas, Xiaoqiang Ding, Zhigang Zhang, Jian-Kang Chen, Huijuan Wu Kidney Int
  Ribosomal protein S6 (rpS6) phosphorylation mediates the hypertrophic growth of kidney proximal tubule cells. However, the role of rpS6 phosphorylation in podocyte hypertrophy and podocyte loss during the pathogenesis of focal segmental glomerulosclerosis (FSGS) remains undefined. Here, we (...) (Kidney International 102, 1 (2022))
• 00:00
  A novel unbiased method reveals progressive podocyte globotriaosylceramide accumulation and loss with age in females with Fabry disease - Behzad Najafian, Aurelio Silvestroni, Alexey Sokolovskiy, Camilla Tøndel, Einar Svarstad, Bogdan Obrisca, Gener Ismail, Myrl D. Holida, Michael Mauer Kidney Int
  While females can suffer serious complications of Fabry disease, most studies are limited to males to avoid confounding by mosaicism. Here, we developed a novel unbiased method for quantifying globotriaosylceramide (GL3) inclusion volume in affected podocytes (F+) in females with Fabry disease (...) (Kidney International 102, 1 (2022))
• 00:00
  Cyclin-dependent kinase 4-related tubular epithelial cell proliferation is regulated by Paired box gene 2 in kidney ischemia-reperfusion injury - Keisuke Sako, Kengo Furuichi, Shohei Makiishi, Yuta Yamamura, Toshiya Okumura, Hong Thu Le, Shinji Kitajima, Tadashi Toyama, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Miho Shimizu, Fumio Niimura, Taiji Matsusaka, Shuichi Kaneko, Takashi Wada Kidney Int
  Paired box 2 (Pax2) is a transcription factor essential for kidney development and is reactivated in proximal tubular epithelial cells (PTECs) during recovery from kidney injury. However, the role of Pax2 in this process is still unknown. Here the role of Pax2 reactivation during injury was (...) (Kidney International 102, 1 (2022))
• 00:00
  Endothelial-specific loss of Krüppel-Like Factor 4 triggers complement-mediated endothelial injury - Chelsea C. Estrada, Stephanie Cardona, Yiqing Guo, Monica P. Revelo, Vivette D. D’Agati, Siva Koganti, Jason Devaraj, John C. He, Peter S. Heeger, Sandeep K. Mallipattu Kidney Int
  Thrombotic microangiopathy (TMA) in the kidney represents the most severe manifestation of kidney microvascular endothelial injury. Despite the source of the inciting event, the diverse clinical forms of kidney TMA share dysregulation of endothelial cell transcripts and complement activation. (...) (Kidney International 102, 1 (2022))
• 00:00
  Variation of the clinical spectrum and genotype-phenotype associations in Coenzyme Q10 deficiency associated glomerulopathy - Stefania Drovandi, Beata S. Lipska-Zi?tkiewicz, Fatih Ozaltin, Francesco Emma, Bora Gulhan, Olivia Boyer, Agnes Trautmann, Szymon Zi?tkiewicz, Hong Xu, Qian Shen, Jia Rao, Korbinian M. Riedhammer, Uwe Heemann, Julia Hoefele, Sarah L. Stenton, Alexey N. Tsygin, Kar-Hui Ng, Svitlana Fomina, Elisa Benetti, Manon Aurelle, Larisa Prikhodina, Anne M. Schijvens, Mansoureh Tabatabaeifar, Maciej Jankowski, Sergey Baiko, Jianhua Mao, Chunyue Feng, Fang Deng, Caroline Rousset-Rouviere, Ma?gorzata Sta?czyk, Irena Ba?asz-Chmielewska, Marc Fila, Anne M. Durkan, Tanja Kersnik Levart, Ismail Dursun, (...) Kidney Int
  Primary Coenzyme Q10 deficiency is a rare mitochondriopathy with a wide spectrum of organ involvement, including steroid-resistant nephrotic syndrome mainly associated with disease-causing variants in the genes COQ2, COQ6 or COQ8B. We performed a systematic literature review, PodoNet, mitoNET, (...) (Kidney International (2022))
• 00:00
  The phenotype of HLA-binding B cells from sensitized kidney transplant recipients correlates with clinically prognostic patterns of interferon-? production against purified HLA proteins - Hannah Burton, Laura McLaughlin, Kin Yee Shiu, Olivia Shaw, Nizam Mamode, Jo Spencer, Anthony Dorling Kidney Int
  B cells play crucial roles in cell-mediated alloimmune responses. In vitro, B cells can support or regulate indirect T-cell alloreactivity in response to donor antigens on ELISpot and these patterns associate with clinical outcome. Previous reports of associations between B-cell phenotype and (...) (Kidney International (2022))
• 00:00
  Protein phosphatase 2Ac? modulates fatty acid oxidation and glycolysis to determine tubular cell fate and kidney injury - Mengru Gu, Mengzhu Tan, Lu Zhou, Xiaoli Sun, Qingmiao Lu, Mingjie Wang, Hanlu Jiang, Yan Liang, Qing Hou, Xian Xue, Zhuo Xu, Chunsun Dai Kidney Int
  Energy metabolism is crucial in maintaining cellular homeostasis and adapting to stimuli for tubular cells. However, the underlying mechanisms remain largely unknown. Here, we report that PP2Ac? was upregulated in damaged tubular cells from patients and animal models with acute or chronic kidney (...) (Kidney International (2022))
• 00:00
  Current kidney function parameters overestimate kidney tissue repair in reversible experimental kidney disease - Barbara Mara Klinkhammer, Simone Buchtler, Sonja Djudjaj, Nassim Bouteldja, Runolfur Palsson, Vidar Orn Edvardsson, Margret Thorsteinsdottir, Jürgen Floege, Matthias Mack, Peter Boor Kidney Int
  Although underlying mechanisms and the clinical course of kidney disease progression are well described, less is known about potential disease reversibility. Therefore, to analyze kidney recovery, we adapted a commonly used murine chronic kidney disease (CKD) model of 2,8- dihydroxyadenine (...) (Kidney International (2022))

22 April

Kidney Int http://www.kidney-international.org/

• 00:00
  Reticulon-1A mediates diabetic kidney disease progression through endoplasmic reticulum-mitochondrial contacts in tubular epithelial cells - Yifan Xie, Jing E, Hong Cai, Fang Zhong, Wenzhen Xiao, Ronald E. Gordon, Lois Wang, Ya-Li Zheng, Aihua Zhang, Kyung Lee, John Cijiang He Kidney Int
  Recent epidemiological studies suggest that some patients with diabetes progress to kidney failure without significant albuminuria and glomerular injury, suggesting a critical role of kidney tubular epithelial cell (TEC) injury in diabetic kidney disease (DKD) progression. However, the major (...) (Kidney International (2022))

20 April

Kidney Int http://www.kidney-international.org/

• 00:00
  Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference - KDIGO Conference Participants Kidney Int
  Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as well as genes for complex kidney diseases that manifest in combination with environmental factors, have been discovered. Genetic findings are increasingly used to inform clinical management of nephropathies, (...) (Kidney International 101, 6 (2022))

13 April

Kidney Int http://www.kidney-international.org/

• 00:00
  The impact of genetic background on mouse models of kidney disease - Rei Bufi, Ron Korstanje Kidney Int
  The mouse is the most commonly used mammalian model to study disease, including kidney disease. However, close attention needs to be paid to the differences and effects of genetic background. The default choice of most investigators is to use C57BL/6 mice, but not all C57BL/6 mice are the same. (...) (Kidney International 102, 1 (2022))
• 00:00
  Suboptimal antibody response against SARS-CoV-2 Omicron variant after third dose of mRNA vaccine in kidney transplant recipients - Ayman Al Jurdi, Rodrigo B. Gassen, Thiago J. Borges, Isadora T. Lape, Leela Morena, Orhan Efe, Zhabiz Solhjou, Rania El Fekih, Christa Deban, Brigid Bohan, Vikram Pattanayak, Camille N. Kotton, Jamil R. Azzi, Leonardo V. Riella Kidney Int
  Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in >5 million deaths worldwide,1 with the Delta (B.1.617.2) and, more recently, the Omicron (B.1.1.529) variants accounting for most cases.2 Kidney transplant recipients (...) (Kidney International 101, 6 (2022))

11 April

Kidney Int http://www.kidney-international.org/

• 00:00
  Humoral response after a fourth “booster” dose of a Coronavirus disease 2019 vaccine following a 3-dose regimen of mRNA-based vaccination in dialysis patients - Pierre Housset, Sabah Kubab, Latifa Hanafi, Agathe Pardon, Nathalie Vittoz, Dogan-Firat Bozman, Valérie Caudwell, Anne-Laure Faucon Kidney Int
  Despite an initial satisfactory increase in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antispike antibody (Ab) titer after completing a 3-dose regimen in the first set of vaccination in dialysis patients,1 Ab titer substantially decreases at 6 months in this population.2 Other (...) (Kidney International 101, 6 (2022))
• 00:00
  Early treatment with sotrovimab monoclonal antibody in kidney transplant recipients with Omicron infection - Nathalie Chavarot, Clea Melenotte, Lucile Amrouche, Claire Rouzaud, Rebecca Sberro-Soussan, Juliette Pavie, Frank Martinez, Anne Pouvaret, Marianne Leruez-Ville, Delphine Cantin, Jacques Fourgeaud, Claire Delage, Damien Vimpere, Marie Noëlle Peraldi, Christophe Legendre, Fanny Lanternier, Julien Zuber, Anne Scemla, Dany Anglicheau Kidney Int
  Early data about coronavirus disease 2019 (COVID-19) related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant (B.1.1.529) suggest that it may be less severe than prior variants of concern in the general population.1–3 However, our preliminary data (NC, personal (...) (Kidney International 101, 6 (2022))

9 April

Kidney Int http://www.kidney-international.org/

• 00:00
  TCR??+ CD4?/CD8– “double negative” T cells in health and disease—implications for the kidney - Andrea M. Newman-Rivera, Johanna T. Kurzhagen, Hamid Rabb Kidney Int
  Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor ?? but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells (...) (Kidney International 102, 1 (2022))

7 April

Kidney Int http://www.kidney-international.org/

• 00:00
  Calculated versus measured albumin-creatinine ratio to predict kidney failure and death in people with chronic kidney disease - Huda Al-Wahsh, Ngan N. Lam, Robert R. Quinn, Paul E. Ronksley, Manish M. Sood, Brenda Hemmelgarn, Navdeep Tangri, Thomas Ferguson, Marcello Tonelli, Pietro Ravani, Ping Liu Kidney Int
  Albumin-to-creatinine ratio (ACR), the preferred method to quantify proteinuria, can be calculated from urine dipstick protein or protein-to-creatinine ratio (PCR). The performance of calculated vs. measured ACR in predicting kidney failure and death without kidney failure in people with (...) (Kidney International 101, 6 (2022))
• 00:00
  Harmonization of epidemiology of acute kidney injury and acute kidney disease produces comparable findings across four geographic populations - Simon Sawhney, Samira Bell, Corri Black, Christian Fynbo Christiansen, Uffe Heide-Jørgensen, Simon Kok Jensen, Paul E. Ronksley, Zhi Tan, Marcello Tonelli, Heather Walker, Matthew T. James Kidney Int
  There is substantial variability in the reported incidence and outcomes of acute kidney injury (AKI). The extent to which this is attributable to differences in source populations versus methodological differences between studies is uncertain. We used 4 population-based datasets from Canada, (...) (Kidney International 101, 6 (2022))

1 April

Kidney Int http://www.kidney-international.org/

• 00:00
  Tubular cell plasticity—new hope for autosomal dominant polycystic kidney disease? - Marine Berquez, Olivier Devuyst Kidney Int
  Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic cause of chronic kidney disease. Typical forms of ADPKD are caused by mutations in either PKD1 or PKD2, encoding polycystin (PC)-1 and PC2, respectively. The polycystins are expressed in various membrane domains, (...) (Kidney International 102, 1 (2022))
• 00:00
  Anti-aging mechanism of calorie restriction in humans - Sho Hasegawa, Masaomi Nangaku Kidney Int
  Animal studies have demonstrated that calorie restriction lowers the incidence of age-related diseases and leads to longer lifespans.1 However, a question that has not been answered is whether long-term calorie restriction has similar beneficial effects in humans. A recent study by Spadaro et (...) (Kidney International (2022))
• 00:00
  Table of Contents Kidney Int
  (Kidney International 101, 4 (2022))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 101, 4 (2022))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 101, 4 (2022))
• 00:00
  Journal Club Kidney Int
  Reindl-Schwaighofer et al. (JAMA Intern Med. 2022;182:165–171.) (Kidney International 101, 4 (2022))
• 00:00
  In This Issue Kidney Int
  Zambrano et al. used single-cell RNA sequencing of glomerular cells from ddY-IgA nephropathy (IgAN) prone mice to study the molecular changes occurring in the kidneys after mesangial IgA deposition, but before structural alterations occur in the kidneys. They found early activation of (...) (Kidney International 101, 4 (2022))
• 00:00
  Semaphorin class 3C, vascular permeability, and the swollen injured kidney - Christian Rosenberger Kidney Int
  Class 3 semaphorins (SEMA3) are secreted glycoproteins with established roles in the developing brain, heart, and kidney. In this issue of Kidney International, Cai et al. show that in acutely injured kidneys, semaphorin isoform SEMA3C is expressed de novo in glomeruli and the nephron, secreted (...) (Kidney International 101, 4 (2022))
• 00:00
  The ins and outs of ferric citrate - Volker H. Haase Kidney Int
  Ferric citrate is used clinically for the treatment of hyperphosphatemia in patients with chronic kidney disease and is approved as an oral iron replacement product for patients with iron-deficiency anemia. In this issue of Kidney International, Hanudel and colleagues take advantage of genetic (...) (Kidney International 101, 4 (2022))
• 00:00
  Donor-derived cell-free DNA in kidney transplantation: evolving concepts and potential limitations - Edmund Huang, Stanley C. Jordan Kidney Int
  Bu et al. report that elevated donor-derived cell-free DNA detected on serial measurements performed for both surveillance and assessment of kidney allograft dysfunction was associated with rejection, future de novo donor-specific antibodies, and decline in estimated glomerular filtration rate. (...) (Kidney International 101, 4 (2022))
• 00:00
  Hypertrophy and glomerular cell adaptation through crosstalk leads to glomerular injury after kidney transplantation - Emelie Lassen, Ilse S. Daehn Kidney Int
  Menon et al. report cell-specific transcriptional changes in podocytes and glomerular endothelial cells that indicate cell stress and increased bidirectional crosstalk among these cells in apparently healthy human allografts. They identified common and independent podocytes and glomerular (...) (Kidney International 101, 4 (2022))
• 00:00
  Multi-omics studies reveal genes critical for AKI and ferroptosis - Midori Sakashita, Masaomi Nangaku Kidney Int
  Family-based linkage studies, more recently combined with exome sequencing, have identified coding regions that explain the development of cystic kidney diseases and nephrotic syndrome, as well as other rare kidney diseases; however, common adult-onset kidney diseases, including hypertensive (...) (Kidney International 101, 4 (2022))
• 00:00
  Absent abdominal musculature in a girl - Detlef Bockenhauer, Imran Mushtaq, Francesca Faravelli Kidney Int
  A 6-month-old girl was referred for further management of her congenital malformations. These were identified antenatally, and, at birth, she was noted to have wrinkled abdominal skin (Figure 1) consistent with the syndrome of absent abdominal musculature (Eagle-Barrett syndrome). The typical (...) (Kidney International 101, 4 (2022))
• 00:00
  The Case | A 17-year-old boy with growth failure and chronic kidney disease - Santhi N. Logel, Ellen L. Connor, Neil J. Paloian Kidney Int
  A 17-year-old boy with no previous medical history presented for evaluation of a left axillary mass. A review of systems was positive for eyelid, hand, and feet edema. He was normotensive. On physical examination, there was a 0.5-cm nonmobile, nontender mass in the left axilla. Laboratory (...) (Kidney International 101, 4 (2022))
• 00:00
  Recurrent hyperparathyroidism presenting as spinal cord compression - Melanie L. Wyld, Labib Rahman, Hayley Collins, Thiveya Theivendran, Angela Bayly, Gopala K. Rangan Kidney Int
  A 32-year-old man with end-stage kidney disease due to IgA nephropathy, on hemodialysis for 6 years, presented with 1 month of severe right hip and upper thigh pain. Twelve months previously, a subtotal parathyroidectomy had been performed. To investigate the cause of his pain, a lower limb (...) (Kidney International 101, 4 (2022))
• 00:00
  Polycystic horseshoe kidney - Madison S. Hill, Michael W. Phelan Kidney Int
  A 57-year-old man presented for a living unrelated kidney transplant. His end-stage kidney disease was secondary to autosomal dominant polycystic kidney disease, and he was coincidentally noted to have a horseshoe kidney on abdominal imaging (Figure 1). He had been maintained on hemodialysis (...) (Kidney International 101, 4 (2022))

30 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Immunoaging within the kidney via injury-associated tertiary lymphoid tissue - A. Richard Kitching Kidney Int
  Past immunologic dogma positioned secondary lymphoid organs—primarily the lymph nodes and the spleen—as the sites where adaptive immune responses were initiated and perpetuated. Solid organs, such as the kidney, were viewed largely as tissues to which cells of the immune system were recruited. (...) (Kidney International 102, 1 (2022))

26 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Effects of acid on bone - David A. Bushinsky, Nancy S. Krieger Kidney Int
  The homeostatic regulation of a stable systemic pH is of critical importance for mammalian survival. During metabolic acidosis (a reduction in systemic pH caused by a primary decrease in serum bicarbonate concentration), as seen in clinical disorders such as the later stages of chronic kidney (...) (Kidney International 101, 6 (2022))

24 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis - Dong Zhou, Yuanyuan Wang, Yuan Gui, Haiyan Fu, Shanshan Zhou, Yanlin Wang, Sheldon I. Bastacky, Donna B. Stolz, Youhua Liu Kidney Int
  Activation of canonical Wnt signaling has been implicated in podocyte injury and proteinuria. As Wnts are secreted proteins, whether Wnts derived from podocytes are obligatory for promoting proteinuria remains unknown. To address this, we generated conditional knockout mice where Wntless, a (...) (Kidney International 102, 1 (2022))
• 00:00
  Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency - Nan Guan, Hanako Kobayashi, Ken Ishii, Olena Davidoff, Feng Sha, Talat A. Ikizler, Chuan-Ming Hao, Navdeep S. Chandel, Volker H. Haase Kidney Int
  Oxidative metabolism in mitochondria regulates cellular differentiation and gene expression through intermediary metabolites and reactive oxygen species. Its role in kidney development and pathogenesis is not completely understood. Here we inactivated ubiquinone-binding protein QPC, a subunit (...) (Kidney International 102, 1 (2022))

23 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation - Rajasree Menon, Andrew S. Bomback, Blue B. Lake, Christy Stutzke, Stephanie M. Grewenow, Steven Menez, Vivette D. D’Agati, Sanjay Jain, Kidney Precision Medicine Project Kidney Int
  Acute kidney injury (AKI) induces a broad range of clinically significant perturbations in kidney morphology and function. Insights into the molecular and cellular basis governing a clinical-pathologic course are limited by the availability of molecular maps of healthy and injured kidney cells. (...) (Kidney International 101, 6 (2022))
• 00:00
  Type I interferon–related kidney disorders - Lorenzo Lodi, Maria V. Mastrolia, Federica Bello, Giovanni M. Rossi, Maria L. Angelotti, Yanick J. Crow, Paola Romagnani, Augusto Vaglio Kidney Int
  Type I interferon (IFN-I) mediates tissue damage in a wide range of kidney disorders, directly affecting the biology and function of several renal cell types including podocytes, mesangial, endothelial, and parietal epithelial cells. Enhanced IFN-I signaling is observed in the context of viral (...) (Kidney International 101, 6 (2022))

22 March

Kidney Int http://www.kidney-international.org/

• 00:00
  The sexual dimorphism of kidney growth in mice and humans - Denise Laouari, Paul Vergnaud, Takuo Hirose, Mohamad Zaidan, Marion Rabant, Clément Nguyen, Martine Burtin, Christophe Legendre, Patrice Codogno, Gerard Friedlander, Dany Anglicheau, Fabiola Terzi Kidney Int
  Kidney mass and function are sexually determined, but the cellular events and the molecular mechanisms involved in this dimorphism are poorly characterized. By combining female and male mice with castration/replacement experiments, we showed that male mice exhibited kidney overgrowth from five (...) (Kidney International 102, 1 (2022))
• 00:00
  Growth differentiation factor-15 preserves Klotho expression in acute kidney injury and kidney fibrosis - Lara Valiño-Rivas, Leticia Cuarental, Maria I. Ceballos, Arancha Pintor-Chocano, Maria Vanessa Perez-Gomez, Ana B. Sanz, Alberto Ortiz, Maria Dolores Sanchez-Niño Kidney Int
  Growth differentiation factor-15 (GDF15) is a member of the GDF subfamily with potential kidney protective functions. Here, we explored the impact of GDF15 on the expression of the kidney protective factor Klotho in models of acute kidney injury and kidney fibrosis in mice. GDF15 was the most (...) (Kidney International 101, 6 (2022))

16 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Concurrent vaccination of kidney transplant recipients and close household cohabitants against COVID-19 - Griffith B. Perkins, Matthew Tunbridge, Tania Salehi, Cheng Sheng Chai, Svjetlana Kireta, Julie Johnston, Daniella Penko, Jodie Nitschke, Arthur Eng Lip Yeow, Zahraa Al-Delfi, Christopher J. Drogemuller, Pablo Garcia-Valtanen, Makutiro G. Masavuli, Christopher M. Hope, Julian Singer, Anupriya Aggarwal, Alberto Ospina Stella, Stuart G. Turville, Plinio R. Hurtado, Simon C. Barry, Pravin Hissaria, Branka Grubor-Bauk, Steven J. Chadban, P. Toby Coates Kidney Int
  Kidney transplant recipients (KTRs) are highly vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severe coronavirus disease 2019 (COVID-19). The 28-day case mortality for KTRs is 24%, and mounting evidence suggests poor immunogenicity and clinical (...) (Kidney International 101, 5 (2022))

14 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Inferior humoral and sustained cellular immunity against wild-type and omicron variant of concern in hemodialysis patients immunized with 3 SARS-CoV-2 vaccine doses compared with 4 doses - Okan Cinkilic, Moritz Anft, Arturo Blazquez-Navarro, Toni L. Meister, Toralf Roch, Ulrik Stervbo, Stephanie Pfaender, Timm H. Westhoff, Nina Babel Kidney Int
  Studies analyzing humoral immunity against the most recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern omicron (B.1.1.529) in the general population demonstrate a clear benefit of an additional boost with respect to neutralization capacity,1 and several (...) (Kidney International 101, 6 (2022))

10 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Americentrism in estimation of glomerular filtration rate equations - Pierre Delanaye, Hans Pottel, Richard J. Glassock Kidney Int
  Social determinants of racial health disparities in kidney disease have an important role as environmental components, especially for Black populations, who are disproportionately disadvantaged, as Black Americans have a much higher risk for progression to kidney failure. The debate concerning (...) (Kidney International 101, 5 (2022))

8 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Hypomorphic expression of parathyroid Bmal1 disrupts the internal parathyroid circadian clock and increases parathyroid cell proliferation in response to uremia - Søren Egstrand, Maria Lerche Mace, Marya Morevati, Anders Nordholm, Lars Henning Engelholm, Jesper Skovhus Thomsen, Annemarie Brüel, Tally Naveh-Many, Yuliu Guo, Klaus Olgaard, Ewa Lewin Kidney Int
  The molecular circadian clock is an evolutionary adaptation to anticipate recurring changes in the environment and to coordinate variations in activity, metabolism and hormone secretion. Parathyroid hyperplasia in uremia is a significant clinical challenge. Here, we examined changes in the (...) (Kidney International 101, 6 (2022))
• 00:00
  Cubilin and amnionless protein are novel target antigens in anti–brush border antibody disease - Johann Morelle, Tiffany Caza, Hanna Debiec, Selda Aydin, Aaron Storey, Pierre Ronco, Christopher Larsen Kidney Int
  The kidney proximal tubule reabsorbs large amounts of low-molecular-weight proteins, albumin, electrolytes, and solutes from the glomerular filtrate to the systemic circulation. Alteration of the specialized transport systems that operate in the brush border of proximal tubule cells leads to (...) (Kidney International 101, 5 (2022))
• 00:00
  Kidney repair and regeneration: perspectives of the NIDDK (Re)Building a Kidney consortium - Bilal A. Naved, Joseph V. Bonventre, Jeffrey A. Hubbell, Neil A. Hukriede, Benjamin D. Humphreys, Carl Kesselman, M. Todd Valerius, Andrew P. McMahon, Stuart J. Shankland, Jason A. Wertheim, Michael J.V. White, Mark P. de Caestecker, Iain A. Drummond Kidney Int
  Acute kidney injury impacts ?13.3 million individuals and causes ?1.7 million deaths per year globally. Numerous injury pathways contribute to acute kidney injury, including cell cycle arrest, senescence, inflammation, mitochondrial dysfunction, and endothelial injury and dysfunction, and can (...) (Kidney International 101, 5 (2022))

7 March

Kidney Int http://www.kidney-international.org/

• 00:00
  High-sensitivity cardiac troponin and the diagnosis of myocardial infarction in patients with kidney impairment - Peter J. Gallacher, Eve Miller-Hodges, Anoop S.V. Shah, Tariq E. Farrah, Nynke Halbesma, James P. Blackmur, Andrew R. Chapman, Philip D. Adamson, Atul Anand, Fiona E. Strachan, Amy V. Ferry, Kuan Ken Lee, Colin Berry, Iain Findlay, Anne Cruickshank, Alan Reid, Alasdair Gray, Paul O. Collinson, Fred S. Apple, David A. McAllister, Donogh Maguire, Keith A.A. Fox, Catriona Keerie, Christopher J. Weir, David E. Newby, Nicholas L. Mills, Neeraj Dhaun, (...) Kidney Int
  The benefit and utility of high-sensitivity cardiac troponin (hs-cTn) in the diagnosis of myocardial infarction in patients with kidney impairment is unclear. Here, we describe implementation of hs-cTnI testing on the diagnosis, management, and outcomes of myocardial infarction in patients with (...) (Kidney International 102, 1 (2022))

6 March

Kidney Int http://www.kidney-international.org/

• 00:00
  The calcium-sensing receptor stabilizes podocyte function in proteinuric humans and mice - Anne K. Mühlig, Johanna Steingröver, Hannah S. Heidelbach, Madelaine Wingerath, Wiebke Sachs, Irm Hermans-Borgmeyer, Catherine Meyer-Schwesinger, Hoon Young Choi, Beom Jin Lim, Christian Patry, Georg Friedrich Hoffmann, Nicole Endlich, Katharina Bracke, Mariella Weiß, Andreas H. Guse, Moritz Lassé, Markus M. Rinschen, Fabian Braun, Tobias B. Huber, Victor G. Puelles, Claus Peter Schmitt, Jun Oh Kidney Int
  Calcimimetic agents allosterically increase the calcium ion sensitivity of the calcium-sensing receptor (CaSR), which is expressed in the tubular system and to a lesser extent in podocytes. Activation of this receptor can reduce glomerular proteinuria and structural damage in proteinuric animal (...) (Kidney International 101, 6 (2022))
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  Progression of established non-diabetic chronic kidney disease is halted by metformin treatment in rats - Raphaëlle Corremans, Ellen Neven, Stuart Maudsley, Hanne Leysen, Marc E. De Broe, Patrick C. D’Haese, Benjamin A. Vervaet, Anja Verhulst Kidney Int
  Current treatment strategies for chronic kidney disease (CKD) mainly focus on controlling risk factors. Metformin, a first-line drug for type 2 diabetes, exerts beneficial pleiotropic actions beyond its prescribed use and incipient data have revealed protective effects against the development (...) (Kidney International 101, 5 (2022))

1 March

Kidney Int http://www.kidney-international.org/

• 00:00
  Table of Contents Kidney Int
  (Kidney International 101, 3 (2022))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 101, 3 (2022))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 101, 3 (2022))
• 00:00
  Don’t deny it! Incremental dialysis is compassionate, logical, and patient-centered - Elizabeth Lindley, James Tattersall Kidney Int
  The 2020 International Society for Peritoneal Dialysis guideline defines incremental peritoneal dialysis (PD) as “a strategy by which less than standard ‘full-dose’ PD is prescribed in people initiating PD, with the intention of increasing the peritoneal prescription if and when residual kidney (...) (Kidney International 101, 3 (2022))
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  The safety and feasibility of incremental dialysis must be proven before its widespread use - Christoph Wanner, Kai Lopau, Henrike Haberstroh Kidney Int
  Incremental dialysis has a long history of use in kidney replacement therapy and is mainly applied to selected individuals commencing maintenance hemodialysis (MHD) and peritoneal dialysis (PD). Most individuals with end-stage kidney disease reluctantly start on maintenance dialysis, mostly due (...) (Kidney International 101, 3 (2022))
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  Initiation of maintenance dialysis: back to the future - T. Alp Ikizler Kidney Int
  Since the very first conceptualization of clearance of toxins by means of dialysis more than a century ago, maintenance dialysis has become a life-sustaining routine treatment, without which more than a million people throughout the world with limited or no kidney function would quickly die.1 (...) (Kidney International 101, 3 (2022))
• 00:00
  In this issue Kidney Int
  Heart failure and kidney failure often occur together and generally portend a poor outcome for patients. Kitani et al. developed a unique model of unilateral kidney congestion to study the pathophysiology of the kidney during heart failure by inferior vena cava constriction. The congested (...) (Kidney International 101, 3 (2022))
• 00:00
  Journal Club Kidney Int
  Kers et al. (Lancet Digit Health. 2022;4:e18–e26.) (Kidney International 101, 3 (2022))
• 00:00
  Corrigendum to Tsuchiyama Y, Wada J, Zhang H, et al. Efficacy of galectins in the amelioration of nephrotoxic serum nephritis in Wistar Kyoto rats. Kidney Int. 2000;58:1941–1952 Kidney Int
  In the above-stated article, the authors mistakenly placed a different experimental group in Figure 3i. Figure 3i now contains the correct experimental group. (Kidney International 101, 3 (2022))
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  Corrigendum to Balbo BE, Amaral AG, Fonseca JM, et al. Cardiac dysfunction in Pkd1-deficient mice with phenotype rescue by galectin-3 knockout. Kidney Int. 2016;90:580–597 Kidney Int
  In the above-stated article, in Figure 8i, due to the similarity between the wild-type (WT) and Pkd1cond/cond (NC) images, the image of NC was inadvertently duplicated in the WT position. Figure 8i now contains the correct image in the WT (...) (Kidney International 101, 3 (2022))
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  Modeling pulse wave velocity trajectories—challenges, opportunities, and pitfalls - Georg Heinze, Jeppe Christensen, Maria C. Haller Kidney Int
  In this commentary, we discuss the analysis of trajectories of pulse wave velocity in a longitudinal cohort study of children with chronic kidney disease (the Cardiovascular Comorbidity in Children with Chronic Kidney Disease – Transplantation study). We revisit the analysis made by the study (...) (Kidney International 101, 3 (2022))
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  Sex differences in cardiovascular disease burden in children with chronic kidney disease - Ashlene M. McKay, Chia Wei Teoh Kidney Int
  Cardiovascular disease is the leading cause of death in children and adults with chronic kidney disease. In this issue, Sugianto et al. demonstrated signs of increased cardiovascular damage (vascular stiffness) in children with chronic kidney disease and highlighted an increased susceptibility (...) (Kidney International 101, 3 (2022))
• 00:00
  Anemia and red blood cell deformability in proteinuric chronic kidney disease - Jaap A. Joles Kidney Int
  Bissinger et al. recently reported that proteinuric chronic kidney disease, in both mice and humans, is associated with reduced red blood cell (RBC) deformability and increased RBC lysophospholipid content.1 Blood albumin levels were not reported but presumably were low in mice with (...) (Kidney International 101, 3 (2022))
• 00:00
  The authors reply - Rosi Bissinger, Bernhard N. Bohnert, Travis Nemkov, Ferruh Artunc Kidney Int
  Dr. Joles recently commented1 on our article,2 discussing the possible implications of hypoalbuminemia, proteinuria, or uremia for the reduced deformability of red blood cells (RBCs) in the 2 proteinuric mouse models of kidney disease–associated anemia investigated in our study.2 In a previous (...) (Kidney International 101, 3 (2022))
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  Daratumumab for multidrug-resistant phospholipase-A2 receptor–related membranous nephropathy - Coralien H. Vink, Bram van Cranenbroek, Joost W. van der Heijden, Hans P.J.M. Koenen, Jack F.M. Wetzels Kidney Int
  At least 10% of patients with anti–phospholipase-A2 receptor antibody (aPLA2R)–associated membranous nephropathy do not attain immunologic remission with standard therapies. Anti–plasma cell therapy with bortezomib has been suggested.1,2 We report the disease course in a patient treated with (...) (Kidney International 101, 3 (2022))
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  LPCing through the nephron accelerates diabetic kidney disease - Jeffrey D. Pressly, Mengyuan Ge, Alessia Fornoni Kidney Int
  Lipid dysmetabolism is emerging as an important contributor to diabetic kidney disease, suggesting that intrarenal lipid accumulation is detrimental to kidney function. This commentary discusses the finding by Yoshioka et al., connecting tubular lipotoxicity induced by an increase in locally (...) (Kidney International 101, 3 (2022))
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  Mathematical modeling of hemodialysis: a tribute to John A. Sargent, PhD (1939–2020) - José A. Moura-Neto, John T. Daugirdas Kidney Int
  While good men of science generally discuss ideas and make their contributions with relevant information to the field, legends pave the way and create the basis for what we know today. This was precisely what Dr. John Sargent (Figure 1) did. Dr. Sargent died on December 4, 2020, at the age of (...) (Kidney International 101, 3 (2022))
• 00:00
  mTOR signaling cascade: novel clinical implications in HLA and non-HLA antibody-mediated vasculopathies? - Kevin Louis, Alexandre Loupy, Carmen Lefaucheur Kidney Int
  Antibodies targeting endothelial antigens represent major threats to the integrity of endothelial vasculature, contributing to development of organ transplant rejection and vasculopathies. In this issue, Catar et al. present the mechanisms by which non-human leukocyte antigen angiotensin II (...) (Kidney International 101, 3 (2022))
• 00:00
  Sortilin, carbamylation, and cardiovascular calcification in chronic kidney disease - Ziad A. Massy, Sophie Liabeuf Kidney Int
  Sortilin appears to play important roles in the pathogenesis of vascular and metabolic diseases, such as cardiovascular calcification. Post-translational modifications of sortilin (i.e., phosphorylation or carbamylation) are among the key mechanisms of its actions. Recent data extended the role (...) (Kidney International 101, 3 (2022))
• 00:00
  The authors reply: - Kavita Gulati, Helena Edwards, Maria Prendecki, Charles D. Pusey, Stephen P. McAdoo Kidney Int
  We thank Drs. Cheng and Gou for their interest in our article.1,2 We agree that there are important differences relating to the use of i.v. methylprednisolone in the Methylprednisolone versus plasma exchange (MEPEX) and Plasma exchange and glucocorticoid dosing in the treatment of (...) (Kidney International 101, 3 (2022))
• 00:00
  Whether the addition of high-dosage methylprednisolone to plasma exchange was more effective than plasma exchange in the treatment for severe antineutrophil cytoplasmic antibody–associated vasculitis? - Lu Cheng, Shen-Ju Gou Kidney Int
  We read with great interest the recent contribution by Gulati et al.1 They retrospectively investigated the effect of a combination regimen of plasma exchange, rituximab, low-dose i.v. cyclophosphamide, and oral glucocorticoids for the treatment of severe anti–neutrophil cytoplasmic (...) (Kidney International 101, 3 (2022))
• 00:00
  The Case | Hypereosinophilia in a hemodialysis patient - Gaspard Lamy, Jean-Emmanuel Kahn, Tessa Huscenot, Mathilde Dargelos, Eve Vilaine, Aymeric Couturier, Panha Chhom, Hamza Ayari, Ziad Albert Massy, Marie Essig Kidney Int
  A 73-year-old man with end-stage kidney disease due to presumed diabetic nephropathy began hemodialysis in July 2020. He was referred with severe hypereosinophilia, which was progressively worsening since September 2020, with a peak eosinophil count of 40.7 × 109/L (...) (Kidney International 101, 3 (2022))
• 00:00
  Valproic acid–associated proximal tubulopathy - Satoru Kudose, Marissa Lipton, Namrata G. Jain, Vivette D. D’Agati Kidney Int
  A 6-year-old Asian boy with ring chromosome 14, global developmental delay, seizure disorder, asthma, chronic respiratory failure requiring ventilatory support, and gastrostomy tube dependence presented with acute kidney injury and Fanconi syndrome. He had been treated with valproic acid (800 (...) (Kidney International 101, 3 (2022))
• 00:00
  Posaconazole-induced podocyte phospholipidosis - Sarwat Gilani, Samih H. Nasr, Sanjeev Sethi Kidney Int
  Podocyte lysosomal vacuolization can be seen in proteinuric diseases, in lysosomal storage diseases, such as Fabry disease, and in association with drugs, such as hydroxychloroquine. A 20-year-old woman underwent heart transplant in 2001 for left hypoplastic heart syndrome. She developed (...) (Kidney International 101, 3 (2022))
• 00:00
  Renal infarction due to COVID-19–associated renal mucormycosis - Anila Abraham Kurien, Nagalakshmi Dhanapal Srinivasaprasad, Kaliyaperumal Thirumal Valavan Kidney Int
  A 32-year-old man, with no comorbidities, was admitted with severe coronavirus disease 2019 (COVID-19) pneumonia. Remdesivir, enoxaparin, methylprednisolone sodium succinate, and tocilizumab were administered, and the patient was put on continuous positive airway pressure therapy. His clinical (...) (Kidney International 101, 3 (2022))

28 February

Kidney Int http://www.kidney-international.org/

• 00:00
  Deficiency of the kidney tubular angiotensin II type1 receptor–associated protein ATRAP exacerbates streptozotocin-induced diabetic glomerular injury via reducing protective macrophage polarization - Kotaro Haruhara, Toru Suzuki, Hiromichi Wakui, Kengo Azushima, Daisuke Kurotaki, Wataru Kawase, Kazushi Uneda, Ryu Kobayashi, Kohji Ohki, Sho Kinguchi, Takahiro Yamaji, Ikuma Kato, Kenichi Ohashi, Akio Yamashita, Tomohiko Tamura, Nobuo Tsuboi, Takashi Yokoo, Kouichi Tamura Kidney Int
  Although activation of the renin-angiotensin system and of its glomerular components is implicated in the pathogenesis of diabetic nephropathy, the functional roles of the tubular renin-angiotensin system with AT1 receptor signaling in diabetic nephropathy are unclear. Tissue hyperactivity of (...) (Kidney International 101, 5 (2022))

26 February

Kidney Int http://www.kidney-international.org/

• 00:00
  When the pooled CRISPR screen meets kidney organoids: toward the identification of new genes and pathways - Chao Zhang, Yun Xia Kidney Int
  Nowadays, genomic sequencing data are being generated at a speed that has outstripped the pace of annotation. Loss-of-function CRISPR screens have been used as a high-throughput approach to determine the functional relevance of individual genes in a specific phenotype by ablating gene (...) (Kidney International 101, 6 (2022))
• 00:00
  A fourth dose of the mRNA-1273 SARS-CoV-2 vaccine improves serum neutralization against the Delta variant in kidney transplant recipients - Ilies Benotmane, Timothée Bruel, Delphine Planas, Samira Fafi-Kremer, Olivier Schwartz, Sophie Caillard Kidney Int
  Research has suggested that even 3 doses of severe acute respiratory syndrome coronavirus 2 mRNA-based vaccines might be unable to elicit a sufficient immune response in immunocompromised kidney transplant recipients.1,2 Although the antibody response mounted by the Pfizer and AstraZeneca (...) (Kidney International 101, 5 (2022))
• 00:00
  Antibody responses to 2 doses of mRNA COVID-19 vaccine in pediatric patients with kidney diseases - Alison Lap-Tak Ma, Daniel Leung, Eugene Yu-Hin Chan, Stella Chim, Samuel Cheng, Fanny Tsz-Wai Ho, Wai-Ming Lai, Pak-Chiu Tong, Matthew Hon-Lam Lee, Wilfred Hing-Sang Wong, Sau Man Chan, Jaime Rosa Duque, Joseph Sriyal Malik Peiris, Yu Lung Lau Kidney Int
  Studies in adult patients with kidney diseases have shown an attenuated immune response to natural coronavirus disease 2019 (COVID-19) and COVID-19 vaccination.1 The pivotal trial of BNT162b2 demonstrated a far higher neutralizing antibody titer in adolescents than in adults.2 Yet, the (...) (Kidney International 101, 5 (2022))

25 February

Kidney Int http://www.kidney-international.org/

• 00:00
  Early increase in single-kidney glomerular filtration rate after living kidney donation predicts long-term kidney function - Jessica van der Weijden, Shekar V.K. Mahesh, Marco van Londen, Stephan J.L. Bakker, Jan-Stephan Sanders, Gerjan Navis, Robert A. Pol, Joke I. Roodnat, Marcia M.L. Kho, Derya Yakar, Thomas C. Kwee, Ilja M. Nolte, Stefan P. Berger, Martin H. De Borst Kidney Int
  Single-kidney glomerular filtration rate (GFR) increases after living kidney donation due to compensatory hyperfiltration and structural changes. The implications of inter-individual variability in this increase in single-kidney GFR are unknown. Here, we aimed to identify determinants of the (...) (Kidney International 101, 6 (2022))
• 00:00
  Mixed-methods research in nephrology - Pippa K. Bailey, Barnaby D. Hole, Lucy A. Plumb, Fergus J. Caskey Kidney Int
  Mixed-methods research involves the mixing of at least 1 qualitative and 1 quantitative method in the same research project or set of related projects. Combined use of qualitative and quantitative research methods in nephrology has increased over the last 10 years. In this review, we aim to (...) (Kidney International 101, 5 (2022))
• 00:00
  Digital spatial profiling of collapsing glomerulopathy - Kelly D. Smith, David K. Prince, Kammi J. Henriksen, Roberto F. Nicosia, Charles E. Alpers, Shreeram Akilesh Kidney Int
  Collapsing glomerulopathy is a histologically distinct variant of focal and segmental glomerulosclerosis that presents with heavy proteinuria and portends a poor prognosis. Collapsing glomerulopathy can be triggered by viral infections such as HIV or SARS-CoV-2. Transcriptional profiling of (...) (Kidney International 101, 5 (2022))
• 00:00
  Association of cardiac autonomic neuropathy assessed by heart rate response during exercise with intradialytic hypotension and mortality in hemodialysis patients - Naoto Usui, Junichiro Nakata, Akimi Uehata, Shuji Ando, Masakazu Saitoh, Sho Kojima, Akihito Inatsu, Hideki Hisadome, Yusuke Suzuki Kidney Int
  The heart rate (HR) reflects the dynamic behavior of the autonomic nervous system, and HR profiles during the exercise test provide prognostic information. However, there are no reports of these factors in hemodialysis patients. Data from 256 patients (mean 68.8 years old) who underwent an (...) (Kidney International 101, 5 (2022))
• 00:00
  Biallelic pathogenic variants in roundabout guidance receptor 1 associate with syndromic congenital anomalies of the kidney and urinary tract - Johannes Münch, Marie Engesser, Ria Schönauer, J. Austin Hamm, Christin Hartig, Elena Hantmann, Gulsen Akay, Davut Pehlivan, Tadahiro Mitani, Zeynep Coban Akdemir, Beyhan Tüysüz, Toshihiko Shirakawa, Sumito Dateki, Laura R. Claus, Albertien M. van Eerde, Genomics England Research Consortium, Thomas Smol, Louise Devisme, Hélène Franquet, Tania Attié-Bitach, Timo Wagner, Carsten Bergmann, Anne Kathrin Höhn, Shirlee Shril, Ari Pollack, Tara Wenger, Abbey A. Scott, Sarah Paolucci, Jillian Buchan, George C. Gabriel, Jennifer E. Posey, James R. Lupski, Florence Petit, Andrew A. McCarthy, Gregory J. (...) Kidney Int
  Congenital anomalies of the kidney and urinary tract (CAKUT) represent the most common cause of chronic kidney failure in children. Despite growing knowledge of the genetic causes of CAKUT, the majority of cases remain etiologically unsolved. Genetic alterations in roundabout guidance receptor (...) (Kidney International 101, 5 (2022))
• 00:00
  Conditional deletion of myeloid-specific mitofusin 2 but not mitofusin 1 promotes kidney fibrosis - Divya Bhatia, Allyson Capili, Kiichi Nakahira, Thangamani Muthukumar, Lisa K. Torres, Augustine M.K. Choi, Mary E. Choi Kidney Int
  Macrophages exert critical functions during kidney injury, inflammation, and tissue repair or fibrosis. Mitochondrial structural and functional aberrations due to an imbalance in mitochondrial fusion/fission processes are implicated in the pathogenesis of chronic kidney disease. Therefore, we (...) (Kidney International 101, 5 (2022))
• 00:00
  Nuclear farnesoid X receptor attenuates acute kidney injury through fatty acid oxidation - Sujuan Xu, Ping Jia, Yi Fang, Jifu Jin, Zhaoxing Sun, Weiran Zhou, Jie Li, Yunlu Zhang, Xiaoyan Wang, Ting Ren, Zhouping Zou, Xiaoqiang Ding Kidney Int
  Acute kidney injury (AKI) is a life-threatening condition that is one of most common side effects of cisplatin therapy. Fatty acid oxidation (FAO) is the main source of energy production in kidney proximal tubular epithelial cells (PTECs) but it is inhibited in AKI. Recent work demonstrated (...) (Kidney International 101, 5 (2022))

21 February

Kidney Int http://www.kidney-international.org/

• 00:00
  Adverse changes in key chronic kidney disease care outcome metrics since the onset of the COVID-19 pandemic: experience from an established provincial renal program - Micheli Bevilacqua, Dilshani Induruwage, Janet Williams, Ognjenka Djurdjev, Adeera Levin Kidney Int
  The onset of the coronavirus disease 2019 (COVID-19) pandemic has resulted in a profound disruption to existing clinical services including chronic kidney disease (CKD) management.1 In the province of British Columbia (BC), Canada, following the onset of the pandemic, dramatic changes in health (...) (Kidney International 101, 5 (2022))

14 February

Kidney Int http://www.kidney-international.org/

• 00:00
  COVID-19 in dialysis: clinical impact, immune response, prevention, and treatment - Khalil El Karoui, An S. De Vriese Kidney Int
  The COVID-19 pandemic has profound adverse effects on the population on dialysis. Patients requiring dialysis are at an increased risk of SARS-CoV-2 infection and mortality, and many have experienced psychological distress as well as delayed or suboptimal care. COVID-19 survivors have prolonged (...) (Kidney International 101, 5 (2022))

12 February

Kidney Int http://www.kidney-international.org/

• 00:00
  Role of uremic toxins in vascular disease—the end of nihilism? - Ziad A. Massy, Tilman B. Drueke Kidney Int
  The liver and kidneys are the main organs involved in the metabolism and elimination of carbohydrates, fats, and proteins, as well as their breakdown products. When kidney or liver function is impaired, these metabolites accumulate and contribute to the clinical features of advanced liver (...) (Kidney International 101, 6 (2022))
• 00:00
  Is HIF activation Janus faced? The therapeutic effects of the HIF-2? inhibitor - Taisuke Ishii, Tetsuhiro Tanaka, Masaomi Nangaku Kidney Int
  von Hippel-Lindau (VHL) disease is a rare autosomal dominant hereditary syndrome that is caused by biallelic VHL inactivation following Knudson’s 2-hit hypothesis of tumorigenesis. Although VHL disease presents with variable phenotypes, inactivation of the VHL protein causes benign and malignant (...) (Kidney International 101, 5 (2022))
• 00:00
  A fourth SARS-CoV-2 mRNA vaccine in strictly seronegative kidney transplant recipients - Christophe Masset, Ilies Benotmane, Jacques Dantal, Claire Garandeau, Gabriella Gauthier-Vargas, Diego Cantarovich, Aurélie Meurette, Magali Giral, Sophie Caillard, Gilles Blancho Kidney Int
  Solid organ transplant recipients have demonstrated a lower humoral immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination, leading transplant physicians to perform a third vaccine injection.1 However, despite this early booster, about 35% of patients (...) (Kidney International 101, 4 (2022))

11 February

Kidney Int http://www.kidney-international.org/

• 00:00
  Breakthrough omicron COVID-19 infections in patients receiving the REGEN-Cov antibody combination - Adrien Flahault, Justine Touchard, Hélène Péré, Laetitia Ulrich, Brigitte Sabatier, David Veyer, David Lebeaux, Eric Thervet Kidney Int
  Coronavirus disease 2019 (COVID-19) vaccines are efficient to prevent severe COVID-19 infections. Immunocompromised patients are at increased risk of both severe COVID-19 and poor immunologic response to anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (...) (Kidney International 101, 4 (2022))
• 00:00
  Letter regarding “diagnosis and treatment of arterial hypertension 2021” - Joachim H. Ix, Charles R.V. Tomson, Alfred K. Cheung, Johannes F.E. Mann, William C. Cushman, Michael Cheung, Tara I. Chang Kidney Int
  We applaud Kidney International for its new series focused on hypertension. As members of the Kidney Disease: Improving Global Outcomes (KDIGO) 2021 Blood Pressure (BP) Guideline writing committee, we worked to design a guideline that would save lives and improve quality of life for chronic (...) (Kidney International 101, 4 (2022))
• 00:00
  The authors reply - Christian Ott, Roland E. Schmieder Kidney Int
  We thank the editor for giving us the opportunity to reply to the letter by Ix et al.1 We acknowledge the honest intention by the Kidney Disease: Improving Global Outcomes (KDIGO) blood pressure (BP) guideline to save lives and improve quality of life for chronic kidney disease (CKD) patients (...) (Kidney International 101, 4 (2022))

3 February

Kidney Int http://www.kidney-international.org/

• 00:00
  A comprehensive assessment of long-term SARS-CoV-2–specific adaptive immune memory in convalescent COVID-19 Solid Organ Transplant recipients - Alexandre Favà, Laura Donadeu, Thomas Jouve, José Gonzalez-Costello, Laura Lladó, Carolina Santana, Néstor Toapanta, Manuel Lopez, Vincent Pernin, Carme Facundo, Nuria Serra Cabañas, Olivier Thaunat, Marta Crespo, Laura Llinàs-Mallol, Ignacio Revuelta, Nuria Sabé, Alexander Rombauts, Laura Calatayud, Carmen Ardanuy, Juliana Esperalba, Candela Fernandez, Juan J. Lozano, Rosemarie Preyer, Kevin Strecker, Carlos Couceiro, Elena García-Romero, Alba Cachero, Maria Meneghini, Alba Torija, Moglie Le Quintrec, Edoardo Melilli, Josep Maria Cruzado, Carolina Polo, Francesc Moreso, Elena Crespo, Oriol (...) Kidney Int
  Long-term adaptive immune memory has been reported among immunocompetent individuals up to eight months following SARS-CoV-2 infection. However, limited data is available in convalescent patients with a solid organ transplant. To investigate this, we performed a thorough evaluation of adaptive (...) (Kidney International 101, 5 (2022))

1 February

Kidney Int http://www.kidney-international.org/

• 00:00
  Inhibition of endoplasmic reticulum stress signaling rescues cytotoxicity of human apolipoprotein-L1 risk variants in Drosophila - Lea Gerstner, Mengmeng Chen, Lina L. Kampf, Julian Milosavljevic, Konrad Lang, Ronen Schneider, Friedhelm Hildebrandt, Martin Helmstädter, Gerd Walz, Tobias Hermle Kidney Int
  Risk variants of the apolipoprotein-L1 (APOL1) gene are associated with severe kidney disease, putting homozygous carriers at risk. Since APOL1 lacks orthologs in all major model organisms, a wide range of mechanisms frequently in conflict have been described for APOL1-associated nephropathies. (...) (Kidney International 101, 6 (2022))
• 00:00
  Trans-ethnic genome-wide association study of blood metabolites in the Chronic Renal Insufficiency Cohort (CRIC) study - Eugene P. Rhee, Aditya Surapaneni, Zihe Zheng, Linda Zhou, Diptavo Dutta, Dan E. Arking, Jingning Zhang, ThuyVy Duong, Nilanjan Chatterjee, Shengyuan Luo, Pascal Schlosser, Rupal Mehta, Sushrut S. Waikar, Santosh L. Saraf, Tanika N. Kelly, Lee L. Hamm, Panduranga S. Rao, Anna V. Mathew, Chi-yuan Hsu, Afshin Parsa, Ramachandran S. Vasan, Paul L. Kimmel, Clary B. Clish, Josef Coresh, Harold I. Feldman, Morgan E. Grams, CKD Biomarkers Consortium and the Chronic Renal Insufficiency Cohort (CRIC) Study (...) Kidney Int
  Metabolomics genome wide association study (GWAS) help outline the genetic contribution to human metabolism. However, studies to date have focused on relatively healthy, population-based samples of White individuals. Here, we conducted a GWAS of 537 blood metabolites measured in the Chronic (...) (Kidney International 101, 4 (2022))
• 00:00
  Table of Contents Kidney Int
  (Kidney International 101, 2 (2022))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 101, 2 (2022))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 101, 2 (2022))
• 00:00
  In this issue Kidney Int
  The unintended consequences of antidiabetic medications have proven to be a win for the kidneys. Several oral agents have robust kidney and cardioprotective effects. A cohort study by Xu et al. extends these observations to the glucagon-like peptide-1 receptor agonists (GLP1-RAs). The kidney (...) (Kidney International 101, 2 (2022))
• 00:00
  Journal Club Kidney Int
  Jorge et al. (Arthritis Care Res [Hoboken]. Published online June 13, 2021. https://doi.org/10.1002/acr.24725) (Kidney International 101, 2 (2022))
• 00:00
  BLISS-LN trial revisited: function matters - Sarah Gleeson, Liz Lightstone Kidney Int
  This post hoc analysis of the Belimumab International Study in Lupus Nephritis (BLISS-LN) shows belimumab effectively reduced the time to 30% and 40% decreases in estimated glomerular filtration rate and persistent decreases in estimated glomerular filtration rate. Subgroup analysis found (...) (Kidney International 101, 2 (2022))
• 00:00
  AA amyloidosis without systemic inflammation: when clinical evidence validates predictions of experimental medicine - Laura Obici, Vittorio Bellotti Kidney Int
  Amyloid A (AA) amyloidosis is a well-known consequence of chronic inflammatory diseases in which elevated plasma concentrations of serum amyloid A result in amyloid aggregation and organ damage. In this issue, Sikora et al. report, for the first time, an inherited form of AA amyloidosis (...) (Kidney International 101, 2 (2022))
• 00:00
  Lipoic acid in neural epidermal growth factor-like 1–associated membranous nephropathy: more than a coincidence? - Tiffany N. Caza, Christopher P. Larsen Kidney Int
  We found the study by Spain et al., “Lipoic Acid Supplementation Associated With Neural Epidermal Growth Factor-Like 1 (NELL1)–Associated Membranous Nephropathy,” to be of great interest.1 We performed a retrospective review of medications in 115 patients with NELL1-positive membranous nephropathy (...) (Kidney International 101, 2 (2022))
• 00:00
  Murine models of uremic cardiomyopathy as a necessary tool to unravel mechanisms involved in cardiorenal syndrome - José Alberto Navarro-García, Gema Ruiz-Hurtado Kidney Int
  Chronic kidney disease (CKD) and cardiovascular disease frequently run in parallel. Herein, Soppert et al. provide an interesting meta-analysis of the effects of CKD on cardiac remodeling and/or function in mice based on the model, strain, and duration. The authors sought to determine the most (...) (Kidney International 101, 2 (2022))
• 00:00
  Insights into vitamin K metabolism in chronic kidney disease: more complicated than kale deficiency - Jennifer S. Lees, Patrick B. Mark Kidney Int
  Vascular calcification is a major manifestation of cardiovascular disease in advanced chronic kidney disease and is inhibited by vitamin K–dependent proteins. Clinical trials of vitamin K supplementation in chronic kidney disease have failed to demonstrate benefits on vascular calcification. (...) (Kidney International 101, 2 (2022))
• 00:00
  Addressing screams for evidence on renoprotection by GLP-1 receptor agonists - Takayoshi Sasako, Toshimasa Yamauchi Kidney Int
  Although growing evidence supports the benefits of glucagon-like peptide-1 receptor agonists, the renoprotective effects were not fully proven in clinical trials. Now, Xu et al. show that glucagon-like peptide-1 receptor agonists reduce the renal outcome compared with dipeptidyl peptidase-4 (...) (Kidney International 101, 2 (2022))
• 00:00
  The authors reply: - Xiubin Li, Junnan Xu Kidney Int
  We thank Calmont1 for her interest in our research focusing on the protection effect of the Semaphorin 4A (Sema4A)–neuropilin-1 (Nrp1) axis on kidney ischemia-reperfusion injury (IRI). Calmont1 pointed out that Xia et al.2 did not find changes in either kidney function or damage in (...) (Kidney International 101, 2 (2022))
• 00:00
  Sema4A-Nrp1 versus Sema4A-plexinB2 in the acutely damaged kidney - Amélie Calmont Kidney Int
  I read with great interest the article by Xu et al., recently published in Kidney International.1 This study reported that Semaphorin 4A (Sema4A) systemic delivery could help recruit neuropilin-1 (Nrp1)–positive regulatory T cells to the kidney and alleviate ischemia-reperfusion injury (IRI). (...) (Kidney International 101, 2 (2022))
• 00:00
  Corrigendum to Cai J, Liu Z, Huang X, et al. The deacetylase sirtuin 6 protects against kidney fibrosis by epigenetically blocking ?-catenin target gene expression Kidney Int. 2020;97:106–118 Kidney Int
  In the above-stated article, in the lower panels of Figure 1a and d, the authors mistakenly used the same Masson staining image for the Sham groups of unilateral ureteral obstruction and ischemia-reperfusion (uIR) models. Figure 1 now contains the correct Masson staining of the Sham group in (...) (Kidney International 101, 2 (2022))
• 00:00
  Urine, doctors, and the acanthocyte’s 30th birthday - Daniel Kraus, Hans Köhler, Julia Weinmann-Menke Kidney Int
  Thirty years ago, in 1991, Kidney International published a seminal article by Hans Köhler, Eveline Wandel, and Bernd Brunck of the University of Mainz, Germany. This article was the first to call peculiarly shaped erythrocytes in the urine “acanthocytes,” and it was the first to systematically (...) (Kidney International 101, 2 (2022))
• 00:00
  The changing role of glucocorticoids in the treatment of anti–neutrophil cytoplasmic antibody–associated vasculitis - Neeraj Dhaun, Stephen P. McAdoo Kidney Int
  Glucocorticoids (GCs) have been a cornerstone of treatment for patients with anti–neutrophil cytoplasm antibody–associated vasculitis (AAV) for decades. They were first used as monotherapy for “polyarteritis” in the 1950s,1,2 and then successfully combined with cyclophosphamide in the 1970s.3 Since (...) (Kidney International 101, 2 (2022))
• 00:00
  Anti-CD38 therapy for PLA2R-positive membranous nephropathy resistant to conventional immunosuppression - Thomas Stehlé, Philippe Grimbert, Philippe Remy, Anissa Moktefi, Vincent Audard, Khalil El Karoui Kidney Int
  In their letter, Salhi et al.1 report a case of phospholipase A2 receptor–positive (PLA2R+) membranous nephropathy (MN) remission after bortezomib treatment, a proteasome inhibitor targeting plasma cells. (Kidney International 101, 2 (2022))
• 00:00
  The Case | An unusual cause of renal vascular thrombi after kidney transplantation - Pauline Erpicum, Stéphanie Grosch, Catherine Bonvoisin, Antoine Bouquegneau, Laurent Weekers, Luc Radermacher, François Jouret, Marie Lejeune, Olivier Hougrand, Christophe Bovy Kidney Int
  In 2008, a 36-year-old woman presented with edema of the lower limbs. Kidney function was normal. Urinalysis revealed nonselective glomerular proteinuria, with hematuria. The classical immune and serological workup was noncontributive. Renal biopsy revealed an immune complex–mediated (...) (Kidney International 101, 2 (2022))
• 00:00
  Noninvasive screening of vancomycin-associated cast nephropathy - Cédric Rafat, Jeremy Zaworski, Yosu Luque, Michel Daudon, Alice Doreille, Laurent Mesnard, Emmanuel Letavernier Kidney Int
  A 62-year-old male patient, weighing 85 kg, was initially admitted for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–related pneumonia complicated by acute respiratory distress syndrome, warranting mechanical ventilation. Initial kidney function was normal (plasma creatinine, 70 (...) (Kidney International 101, 2 (2022))
• 00:00
  Acute methotrexate-induced crystal nephropathy - Matthew F. Blum, Mohamed G. Atta Kidney Int
  A 79-year-old woman with primary diffuse large B-cell lymphoma of the central nervous system was admitted for high-dose methotrexate and rituximab administration. After receiving oral and isotonic i.v. sodium bicarbonate to achieve an alkaline urine pH, she received 4.96 g/m2 of i.v. (...) (Kidney International 101, 2 (2022))
• 00:00
  Diagnosis of AApoAIV medullary amyloidosis at radical nephrectomy - Paul E. Rosenstiel, Tahira Alves Kidney Int
  A 66-year-old man with end-stage kidney disease attributed to hypertension and diabetes presented with an incidental 1.8-cm lesion in the right kidney. A nephrectomy was performed and a benign hemorrhagic renal cyst (not shown) was identified. In addition, gross anatomic assessment of the (...) (Kidney International 101, 2 (2022))

31 January

Kidney Int http://www.kidney-international.org/

• 00:00
  Histologically resolved small RNA maps in primary focal segmental glomerulosclerosis indicate progressive changes within glomerular and tubulointerstitial regions - Anna Marie Williams, David M. Jensen, Xiaoqing Pan, Pengyuan Liu, Jing Liu, Sean Huls, Kevin R. Regner, Kenneth A. Iczkowski, Feng Wang, Junhui Li, Alexander J. Gallan, Tao Wang, Maria Angeles Baker, Yong Liu, Nava Lalehzari, Mingyu Liang Kidney Int
  Pathological heterogeneity is common in clinical tissue specimens and complicates the interpretation of molecular data obtained from the specimen. As a typical example, a kidney biopsy specimen often contains glomeruli and tubulointerstitial regions with different levels of histological injury, (...) (Kidney International 101, 4 (2022))
• 00:00
  Kidney health for all: bridging the gap in kidney health education and literacy - Robyn G. Langham, Kamyar Kalantar-Zadeh, Ann Bonner, Alessandro Balducci, Li-Li Hsiao, Latha A. Kumaraswami, Paul Laffin, Vassilios Liakopoulos, Gamal Saadi, Ekamol Tantisattamo, Ifeoma Ulasi, Siu-Fai Lui, World Kidney Day Joint Steering Committee Kidney Int
  The high burden of kidney disease, global disparities in kidney care, and poor outcomes of kidney failure bring a concomitant growing burden to persons affected, their families, and carers, and the community at large. Health literacy is the degree to which persons and organizations have or (...) (Kidney International 101, 3 (2022))

30 January

Kidney Int http://www.kidney-international.org/

• 00:00
  New-onset class III lupus nephritis with multi-organ involvement after COVID-19 vaccination - Hyo Jeong Kim, Minsun Jung, Beom Jin Lim, Seung Hyeok Han Kidney Int
  Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can trigger an autoimmune response. Two cases of lupus nephritis after the administration of the mRNA vaccine (BNT162b2, Pfizer–BioNTech) and the adenoviral vector vaccine (AZD1222 [ChAdOx1-S], AstraZeneca) have (...) (Kidney International 101, 4 (2022))

25 January

Kidney Int http://www.kidney-international.org/

• 00:00
  Concomitant loss of regulatory T and B cells is a distinguishing immune feature of antibody-mediated rejection in kidney transplantation - Kevin Louis, Paul Fadakar, Camila Macedo, Masaki Yamada, Michelle Lucas, Xinyan Gu, Adriana Zeevi, Parmjeet Randhawa, Carmen Lefaucheur, Diana Metes Kidney Int
  Although considerable advances have been made in understanding the cellular effector mechanisms responsible for donor-specific antibody generation leading to antibody-mediated rejection (ABMR), the identification of cellular regulators of such immune responses is lacking. To clarify this, we (...) (Kidney International 101, 5 (2022))
• 00:00
  Genetic inactivation of Semaphorin 3C protects mice from acute kidney injury - Anxiang Cai, Guanyu Ye, Sandrine Placier, Perrine Frère, Brigitte Surin, Sophie Vandermeersch, Raphael Kormann, Yi-Chun Xu-Dubois, Magali Genest, Morgane Lannoy, Christos E. Chadjichristos, Jean-Claude Dussaule, Peter J. Scambler, Christos Chatziantoniou, Amélie Calmont Kidney Int
  To guide the development of therapeutic interventions for acute kidney injury, elucidating the deleterious pathways of this global health problem is highly warranted. Emerging evidence has indicated a pivotal role of endothelial dysfunction in the etiology of this disease. We found that the (...) (Kidney International 101, 4 (2022))

12 January

Kidney Int http://www.kidney-international.org/

• 00:00
  A prospective cross-sectional study estimated glomerular filtration rate from creatinine and cystatin C in adults with solid tumors - Verônica T. Costa e Silva, Luiz A. Gil, Lesley A. Inker, Renato A. Caires, Elerson Costalonga, George Coura-Filho, Marcelo T. Sapienza, Gilberto Castro, Maria DP. Estevez-Diz, Dirce Maria T. Zanetta, Leila Antonângelo, Lia Marçal, Hocine Tighiouart, Shiyuan Miao, Paul Mathew, Andrew S. Levey, Emmanuel A. Burdmann Kidney Int
  Current guidelines recommend estimating glomerular filtration rate (eGFR) using creatinine (eGFRcr) with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation as the first test for GFR evaluation, but the Cockcroft-Gault (CG) equation is still commonly used in oncology (...) (Kidney International 101, 3 (2022))

11 January

Kidney Int http://www.kidney-international.org/

• 00:00
  Kidney traits on repeat—the role of MUC1 VNTR - Eric Olinger, Ian Wilson, Olivier Devuyst, John A. Sayer Kidney Int
  To a non-geneticist, variable number tandem repeat (VNTR) genetic variants may be a mystery, and indeed we are only beginning to understand their role in rare and complex diseases. VNTRs are genomic sequences seven to thousands of base pairs long that are repeated in tandem from two to hundreds (...) (Kidney International 101, 5 (2022))
• 00:00
  Diffusion-magnetic resonance imaging predicts decline of kidney function in chronic kidney disease and in patients with a kidney allograft - Lena Berchtold, Lindsey A. Crowe, Christophe Combescure, Miklos Kassaï, Ibtisam Aslam, David Legouis, Solange Moll, Pierre-Yves Martin, Sophie de Seigneux, Jean-Paul Vallée Kidney Int
  Kidney cortical interstitial fibrosis is highly predictive of kidney prognosis and is currently assessed by evaluation of a biopsy. Diffusion-weighted magnetic resonance imaging is a promising non-invasive tool to evaluate kidney fibrosis. We recently adapted diffusion-weighted imaging sequence (...) (Kidney International 101, 4 (2022))

10 January

Kidney Int http://www.kidney-international.org/

• 00:00
  Divergent roles of haptoglobin and hemopexin deficiency for disease progression of Shiga-toxin–induced hemolytic-uremic syndrome in mice - Wiebke Pirschel, Antonio N. Mestekemper, Bianka Wissuwa, Nadine Krieg, Sarah Kröller, Christoph Daniel, Florian Gunzer, Emanuela Tolosano, Michael Bauer, Kerstin Amann, Stefan H. Heinemann, Sina M. Coldewey Kidney Int
  Thrombotic microangiopathy, hemolysis and acute kidney injury are typical clinical characteristics of hemolytic-uremic syndrome (HUS), which is predominantly caused by Shiga-toxin–producing Escherichia coli. Free heme aggravates organ damage in life-threatening infections, even with a low degree (...) (Kidney International 101, 6 (2022))

4 January

Kidney Int http://www.kidney-international.org/

• 00:00
  SARS-CoV-2 vaccination–associated collapsing glomerulopathy in a kidney transplant recipient - Julia Jefferis, Andrew J. Kassianos, Anca Grivei, Brian Doucet, Helen Healy, Leo Francis, Saw Yu Mon, George T. John Kidney Int
  A stable kidney transplant recipient (KTR) of 14 years received the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ChAdOx1 (AZD1222) vaccine and, within a fortnight, presented with severe acute kidney injury (creatinine, 533 ?mol/L; baseline, 125–187 ?mol/L) and nephrotic range (...) (Kidney International 101, 3 (2022))

3 January

Kidney Int http://www.kidney-international.org/

• 00:00
  Aquaporin-1 variants: a step further towards precise prescription in peritoneal dialysis? - Osama El Shamy, T. Alp Ikizler Kidney Int
  With a concerted effort to increase home dialysis utilization, it is crucial to better understand patient characteristics that affect the quality of dialysis delivered, as well as the likelihood of technique failure. In peritoneal dialysis (PD), the quality of dialysis is dictated by the (...) (Kidney International 101, 3 (2022))
• 00:00
  REGEN-Cov antibody combination to prevent COVID-19 infection in kidney transplant recipient without detectable antibody response to optimal vaccine scheme - Didier Ducloux, Cécile Courivaud Kidney Int
  Many kidney transplant recipients (KTRs) do not respond to an anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. Indeed, concordant data indicate that about 30% of KTRs do not develop antibodies after 3 doses of mRNA vaccines.1,2 However, KTRs are at a high risk of severe (...) (Kidney International 101, 3 (2022))
• 00:00
  Collapsing glomerulopathy following SARS-CoV-2 adenovirus-vector–based vaccine: report of 2 cases - Precil D. Neves, Renato A. Caires, Manoel P. Guimarães, Elerson C. Costalonga, Livia B. Cavalcante, Verônica T. Costa e Silva, Francisco Z. Mattedi, Leonardo F. Santana, Antônio A. Teixeira-Júnior, Orlando V. Gomes, Gyl E. Silva, Emmanuel A. Burdmann, Luiz F. Onuchic Kidney Int
  In the setting of the rapid spread of the pandemic by the new coronavirus disease 2019 (COVID-19) and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the kidney was recognized as a frequent target.1 With the beginning of vaccination for COVID-19, several cases of (...) (Kidney International 101, 3 (2022))

1 January

Kidney Int http://www.kidney-international.org/

• 00:00
  Table of Contents Kidney Int
  (Kidney International 101, 1 (2022))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 101, 1 (2022))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 101, 1 (2022))
• 00:00
  Journal Club Kidney Int
  Neal B et al. (N Engl J Med. 2021;385:1067–1077.) (Kidney International 101, 1 (2022))
• 00:00
  The authors reply - Jack F.M. Wetzels, Pierre Ronco, Vivekanand Jha, KDIGO Membranous Nephropathy Working Group Kidney Int
  We thank Drs. Li and Zhang for their comments, and take the opportunity to explain the advice.1 The revised Kidney Disease: Improving Global Outcomes (KDIGO) guidelines2 have introduced practice points to acknowledge the lack of solid evidence, in the absence of randomized controlled trials. As (...) (Kidney International 101, 1 (2022))
• 00:00
  Comments on the 2021 Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline for anticoagulant therapy in patients with membranous nephropathy - Xiaomin Li, Xiaoliang Zhang Kidney Int
  Kidney International published “KDIGO 2021 clinical practice guideline for the management of glomerular diseases,”1 which represents an update to the Kidney Disease: Improving Global Outcomes (KDIGO) 2012 guideline on the topic of anticoagulant therapy in patients with membranous nephropathy. (...) (Kidney International 101, 1 (2022))
• 00:00
  In this issue Kidney Int
  In a prespecified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease trial (DAPA-CKD), the investigators examined the effect of dapagliflozin on the incidence of severe acute kidney injury (AKI) in their large cohort of patients with CKD. AKI was defined (...) (Kidney International 101, 1 (2022))
• 00:00
  One small mouse step for man - Roderick J. Tan Kidney Int
  The effect of spaceflight on kidney function requires additional study. The nuclear factor erythroid 2-related factor 2 knockout mouse became the first genetically engineered strain sent into orbit and to return to earth alive. In this issue, Suzuki et al. provide kidney analyses of these (...) (Kidney International 101, 1 (2022))
• 00:00
  Early post-transplant recurrence of oxalate nephropathy in a patient with primary hyperoxaluria type 1, despite pretransplant lumasiran therapy - Nizar Joher, Anissa Moktefi, Philippe Grimbert, Eléonore Pagot, Narindra Jouan, Khalil El Karoui, Cécile Maud Champy, Marie Matignon, Thomas Stehlé Kidney Int
  Lumasiran, an RNA interference agent targeting glycolate oxidase to reduce hepatic oxalate synthesis, is a breakthrough therapy in the treatment of primary hyperoxaluria type 1.1 (Kidney International 101, 1 (2022))
• 00:00
  Therapeutic potential of Beclin1 for transition from AKI to CKD: autophagy-dependent and autophagy-independent functions - Satoshi Minami, Shuhei Nakamura Kidney Int
  Acute kidney injury (AKI) increases the risk of chronic kidney disease (CKD), but the mechanisms of CKD development after AKI remain unclear. Recent studies have elucidated that autophagy protects against AKI, but the role of autophagy during the AKI-to-CKD transition is controversial. Beclin1 (...) (Kidney International 101, 1 (2022))
• 00:00
  Macrophage dynamics in kidney repair: elucidation of a COX-2–dependent MafB pathway to affect macrophage differentiation - David P. Basile Kidney Int
  Cylocloxygenase-2 is an important mediator of arachidonic acid metabolism. Pan et al. recently identified a robust increase in the expression of cylocloxygenase-2 in proresolving macrophages (M2) during the repair phase of acute kidney injury. The investigators determined the prostaglandin E2 (...) (Kidney International 101, 1 (2022))
• 00:00
  SGLT2 inhibition in chronic kidney disease: a preventive strategy against acute kidney injury at the same time? - Sho Hasegawa, Masaomi Nangaku Kidney Int
  Sodium-glucose co-transporter 2 (SGLT2) inhibitors are known to slow down progression of chronic kidney disease. However, theoretical concerns still exist that SGLT2 inhibitors could increase the risk of acute kidney injury. Heerspink et al. revealed that dapagliflozin, an SGLT2 inhibitor, (...) (Kidney International 101, 1 (2022))
• 00:00
  The Case | Persistent fever in a hemodialysis patient - Diana Rodríguez-Espinosa, José Jesús Broseta, Marta Garrote, Luis F. Quintana, Miquel Blasco, Federico Oppenheimer Kidney Int
  A 52-year-old man on maintenance hemodialysis through a tunneled jugular central venous catheter was referred for fever and chills and a 3 kg weight loss in the previous month. His medical history included end-stage kidney disease due to chronic pyelonephritis and 3 previous kidney transplants. (...) (Kidney International 101, 1 (2022))
• 00:00
  Windswept deformity of lower limbs in a patient with end-stage renal disease and rickets - Vidhya K. Zachariah, Suresh B. Gandhi, V.C. Sunitha, P.S. Priyamvada, S. Parameswaran Kidney Int
  A 22-year-old man with kidney failure was referred to us for progressive deformities of the lower limbs. He developed knock knees at 15 years and underwent orthopedic procedures in both knees. He was referred to the Department of Nephrology for a “kidney problem,” but he did not follow up. The (...) (Kidney International 101, 1 (2022))
• 00:00
  Catastrophic kidney infarction - Nattawat Klomjit, Ladan Zand Kidney Int
  A 62-year-old man with a history of stroke, ischemic cardiomyopathy, and paroxysmal atrial fibrillation not on anticoagulation presented with left lower extremity weakness and numbness and was found to have left lower extremity ischemia on examination. There was also evidence of acute kidney (...) (Kidney International 101, 1 (2022))
• 00:00
  An unusual case of anuric acute kidney injury in a patient with metastatic lung cancer - Cédric Aglae, Olivier Moranne, Pedram Ahmadpoor, Laurent Daniel, Florian Garo Kidney Int
  A 57-year-old patient with known history of stage IIIa chronic kidney disease (Chronic Kidney Disease Epidemiology Collaboration, 54 ml/min per 1.73 m2) was admitted on February 7, 2020, for generalized edema, oliguria, and acute kidney injury. Previously, a lung squamous cell carcinoma, with (...) (Kidney International 101, 1 (2022))

27 December

Kidney Int http://www.kidney-international.org/

• 00:00
  A novel role of BK potassium channel activity in preventing the development of kidney fibrosis - Yinhang Wang, Mengling Wang, Fengling Ning, Dadui Ren, Jie Tao, Weiyi Xie, Douglas C. Eaton, Gengru Jiang, Alton B. Farris, Hong Xin, Hui Cai, Xuemei Zhang Kidney Int
  Kidney fibrosis is a common characteristic of chronic kidney disease and while the large conductance voltage and calcium-activated potassium channel (BK) is widely expressed in kidneys, its role in kidney fibrosis is unknown. To evaluate this, we found that BK protein expression was decreased (...) (Kidney International 101, 5 (2022))
• 00:00
  Molecular insights into the early stage of glomerular injury in IgA nephropathy using single-cell RNA sequencing - Sonia Zambrano, Liqun He, Toshiki Kano, Ying Sun, Emmanuelle Charrin, Mark Lal, Christer Betsholtz, Yusuke Suzuki, Jaakko Patrakka Kidney Int
  IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide and defined by the presence of IgA-containing immune complexes in the mesangium that induce an inflammation leading to glomerulonephritis. Since we poorly understand early mechanisms of glomerular injury in IgAN we (...) (Kidney International 101, 4 (2022))

22 December

Kidney Int http://www.kidney-international.org/

• 00:00
  Results of the prospective multicenter SoLKiD cohort study indicate bio-psycho-social outcome risks to kidney donors 12 months after donation - Barbara Suwelack, Klaus Berger, Heiner Wolters, Joachim W.O. Gerß, Eike Bormann, Viktorya Wörmann, Markus Burgmer, SoLKiD study group Kidney Int
  The outcome after living kidney donation was assumed to be comparable to that of the general population. However, recent register studies reveal negative changes in kidney function, quality of life and fatigue. Avoiding methodological issues of previous studies, the Safety of the Living Kidney (...) (Kidney International 101, 3 (2022))
• 00:00
  Natural SARS-CoV-2 infection results in higher neutralization response against variants of concern compared with 2-dose BNT162b2 vaccination in kidney transplant recipients - Louise Benning, Christian Morath, Marie Bartenschlager, Marvin Reineke, Maximilian Töllner, Christian Nusshag, Florian Kälble, Paula Reichel, Matthias Schaier, Paul Schnitzler, Martin Zeier, Caner Süsal, Ralf Bartenschlager, Claudius Speer Kidney Int
  Seroconversion rates in kidney transplant recipients (KTRs) after 2-dose BNT162b2 (Pfizer–BioNTech) mRNA vaccination are in the range of 3%–59% and thus are significantly lower compared with the >90% achieved in healthy controls.1 In convalescent coronavirus disease 2019 (COVID-19) patients, (...) (Kidney International 101, 3 (2022))

21 December

Kidney Int http://www.kidney-international.org/

• 00:00
  Elamipretide treatment during pregnancy ameliorates the progression of polycystic kidney disease in maternal and neonatal mice with PKD1 mutations - Nastaran Daneshgar, Peir-In Liang, Renny S. Lan, McKenna M. Horstmann, Lindsay Pack, Gourav Bhardwaj, Christie M. Penniman, Brian T. O’Neill, Dao-Fu Dai Kidney Int
  Pregnancy is proposed to aggravate cyst progression in autosomal dominant polycystic kidney disease (ADPKD) but Tolvaptan, the only FDA-approved drug for adult ADPKD, is not recommended for pregnant ADPKD patients because of potential fetal harm. Since pregnancy itself may increase the risk for (...) (Kidney International 101, 5 (2022))
• 00:00
  Glomerular endothelial cell-podocyte stresses and crosstalk in structurally normal kidney transplants - Rajasree Menon, Edgar A. Otto, Celine C. Berthier, Viji Nair, Evan A. Farkash, Jeffrey B. Hodgin, Yingbao Yang, Jinghui Luo, Kenneth J. Woodside, Haniyeh Zamani, Silas P. Norman, Roger C. Wiggins, Matthias Kretzler, Abhijit S. Naik Kidney Int
  Increased podocyte detachment begins immediately after kidney transplantation and is associated with long-term allograft failure. We hypothesized that cell-specific transcriptional changes in podocytes and glomerular endothelial cells after transplantation would offer mechanistic insights into (...) (Kidney International 101, 4 (2022))
• 00:00
  Clinical outcomes from the Assessing Donor-derived cell-free DNA Monitoring Insights of kidney Allografts with Longitudinal surveillance (ADMIRAL) study - Lihong Bu, Gaurav Gupta, Akshta Pai, Sanjiv Anand, Erik Stites, Irfan Moinuddin, Victor Bowers, Pranjal Jain, David A. Axelrod, Matthew R. Weir, Theresa K. Wolf-Doty, Jijiao Zeng, Wenlan Tian, Kunbin Qu, Robert Woodward, Sham Dholakia, Aleskandra De Golovine, Jonathan S. Bromberg, Haris Murad, Tarek Alhamad Kidney Int
  The use of routine monitoring of donor-derived cell-free DNA (dd-cfDNA) after kidney transplant may allow clinicians to identify subclinical allograft injury and intervene prior to development of clinically evident graft injury. To evaluate this, data from 1092 kidney transplant recipients (...) (Kidney International 101, 4 (2022))

20 December

Kidney Int http://www.kidney-international.org/

• 00:00
  Findings from 4C-T Study demonstrate an increased cardiovascular burden in girls with end stage kidney disease and kidney transplantation - Rizky I. Sugianto, Nima Memaran, Bernhard M.W. Schmidt, Anke Doyon, Daniela Thurn-Valsassina, Harika Alpay, Ali Anarat, Klaus Arbeiter, Karolis Azukaitis, Aysun K. Bayazit, Ipek K. Bulut, Salim Caliskan, Nur Canpolat, Ali Duzova, Jutta Gellerman, Jerome Harambat, Denise Homeyer, Mieczyslaw Litwin, Francesca Mencarelli, Lukasz Obrycki, Dusan Paripovic, Bruno Ranchin, Rukshana Shroff, Uwe Tegtbur, Jeannine von der Born, Ebru Yilmaz, Uwe Querfeld, Elke Wühl, Franz Schaefer, Anette (...) Kidney Int
  Mortality in children with kidney failure is higher in girls than boys with cardiovascular complications representing the most common causes of death. Pulse wave velocity (PWV), a measure of vascular stiffness, predicts cardiovascular mortality in adults. Here, PWV in children with kidney (...) (Kidney International 101, 3 (2022))

17 December

Kidney Int http://www.kidney-international.org/

• 00:00
  A glomerular transcriptomic landscape of apolipoprotein L1 in Black patients with focal segmental glomerulosclerosis - Michelle T. McNulty, Damian Fermin, Felix Eichinger, Dongkeun Jang, Matthias Kretzler, Noël P. Burtt, Martin R. Pollak, Jason Flannick, Astrid Weins, David J. Friedman, Nephrotic Syndrome Study Network (NEPTUNE), Matthew G. Sampson Kidney Int
  Apolipoprotein L1 (APOL1)-associated focal segmental glomerulosclerosis (FSGS) is the dominant form of FSGS in Black individuals. There are no targeted therapies for this condition, in part because the molecular mechanisms underlying APOL1’s pathogenic contribution to FSGS are incompletely (...) (Kidney International 102, 1 (2022))

16 December

Kidney Int http://www.kidney-international.org/

• 00:00
  Thirty years of the International Banff Classification for Allograft Pathology: the past, present, and future of kidney transplant diagnostics - Alexandre Loupy, Michael Mengel, Mark Haas Kidney Int
  2021 marks the 30th anniversary of the original development of the Banff Classification of Kidney Allograft Pathology, when in August 1991 a group of pathologists and transplant clinicians led by Kim Solez and Lorraine Racusen met in Banff, Alberta, Canada, and established the first widely (...) (Kidney International 101, 4 (2022))
• 00:00
  Scaffold polarity proteins Par3A and Par3B share redundant functions while Par3B acts independent of atypical protein kinase C/Par6 in podocytes to maintain the kidney filtration barrier - Sybille Koehler, Johanna Odenthal, Vivian Ludwig, David Unnersjö Jess, Martin Höhne, Christian Jüngst, Ferdi Grawe, Martin Helmstädter, Johanna L. Janku, Carsten Bergmann, Peter F. Hoyer, H. Henning Hagmann, Gerd Walz, Wilhelm Bloch, Carien Niessen, Bernhard Schermer, Andreas Wodarz, Barry Denholm, Thomas Benzing, Sandra Iden, Paul T. Brinkkoetter Kidney Int
  Glomerular diseases are a major cause for chronic kidney disorders. In most cases podocyte injury is causative for disease development. Cytoskeletal rearrangements and morphological changes are hallmark features of podocyte injury and result in dedifferentiation and loss of podocytes. Here, we (...) (Kidney International 101, 4 (2022))

12 December

Kidney Int http://www.kidney-international.org/

• 00:00
  Allorecognition and the spectrum of kidney transplant rejection - Jasper Callemeyn, Baptiste Lamarthée, Alice Koenig, Priyanka Koshy, Olivier Thaunat, Maarten Naesens Kidney Int
  Detection of mismatched human leukocyte antigens by adaptive immune cells is considered as the main cause of transplant rejection, leading to either T-cell mediated rejection or antibody-mediated rejection. This canonical view guided the successful development of immunosuppressive therapies and (...) (Kidney International 101, 4 (2022))

10 December

Kidney Int http://www.kidney-international.org/

• 00:00
  KDIGO recommendations for the evaluation of glycemic control in advanced chronic kidney disease - Vivian Fonseca, Takuji Kohzuma, Rodolfo J. Galindo, Cyrus DeSouza Kidney Int
  The “KDIGO 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease”1 is a useful resource for clinicians and patients. The guideline states “Hemoglobin A1c (HbA1c) is recommended to monitor glycemic control in patients with diabetes and CKD”1(pS23) and “Accuracy and (...) (Kidney International 101, 2 (2022))
• 00:00
  The authors reply: - M. Luiza Caramori, Katherine R. Tuttle, Nikhil Tandon, David J. Tunnicliffe, Ian H. de Boer, Peter Rossing, Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group Kidney Int
  The Kidney Disease: Improving Global Outcomes (KDIGO) 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease Work Group1 agrees with the statement by Fonseca et al.2 that hemoglobin A1c (HbA1c) may be unreliable in advanced chronic kidney disease (CKD). In addition (...) (Kidney International 101, 2 (2022))

7 December

Kidney Int http://www.kidney-international.org/

• 00:00
  Observations on improving COVID-19 vaccination responses in kidney transplant recipients: heterologous vaccination and immunosuppression modulation - Christophe Masset, Simon Ville, Claire Garandeau, Florent Le Borgne, Thibaut Letellier, Diego Cantarovich, Aurélie Meurette, Cécile Guillot-Gueguen, Maxime Bentoumi-Loaec, Magali Giral, Jacques Dantal, Gilles Blancho Kidney Int
  Solid organ transplant recipients have a weaker humoral response to coronavirus disease 2019 (COVID-19) vaccination because of several factors, including lymphopenia associated with immunosuppressive therapies (particularly belatacept, antiproliferative drugs, and steroids).1 Because of the (...) (Kidney International 101, 3 (2022))

2 December

Kidney Int http://www.kidney-international.org/

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  Prediction models of treatment response in lupus nephritis - Isabelle Ayoub, Bethany J. Wolf, Linyu Geng, Huijuan Song, Aastha Khatiwada, Betty P. Tsao, Jim C. Oates, Brad H. Rovin Kidney Int
  In order to develop prediction models of one-year treatment response in lupus nephritis, an approach using machine learning to combine traditional clinical data and novel urine biomarkers was undertaken. Contemporary lupus nephritis biomarkers were identified through an unbiased PubMed search. (...) (Kidney International 101, 2 (2022))

1 December

Kidney Int http://www.kidney-international.org/

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  TOC - 5 pages Kidney Int
  (Kidney International 100, 6 (2021))
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  Subscription Information Kidney Int
  (Kidney International 100, 6 (2021))
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  Editorial Board Kidney Int
  (Kidney International 100, 6 (2021))
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  In This Issue Kidney Int
  The over-the-counter supplement lipoic acid (LA) is thought to be an antioxidant. Spain et al. report the unexpected development of proteinuria in 3 patients with multiple sclerosis (MS) who were receiving LA in a clinical trial for MS. Two patients had kidney biopsies and were found to have a (...) (Kidney International 100, 6 (2021))
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  Journal Club Kidney Int
  Yau et al. (Evaluation of the SARS-CoV-2 antibody response to the BNT162b2 vaccine in patients undergoing hemodialysis. JAMA Netw Open. 2021;4:e2123622.) (Kidney International 100, 6 (2021))
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  Corrigendum to Wu L, Liu C, Chang D-Y, et al. Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy. Kidney Int. 2021;100:107–121 Kidney Int
  The authors regret that in the above-stated article, in Figure 6d, the labels of the bar graph were reversed. Specifically, the blue bar in the lower left column is siCtrl + HGPA, and the red bar in the lower right column is siANXA1 + (...) (Kidney International 100, 6 (2021))
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  Corrigendum to Liu J, Kesiry R, Periyasamy SM, et al. Ouabain induces endocytosis of plasmalemmal Na/K-ATPase in LLC-PK1 cells by a clathrin-dependent mechanism. Kidney Int. 2004;66:227–241 Kidney Int
  Upon reviewing the above-stated article, the authors realized that they had inadvertently duplicated an inverted a panel. The authors have corrected the middle panel of Figure 9a, which contained incorrect blots representing the immunoprecipitation of AP-2? and then immunoblotting for ?1 subunit (...) (Kidney International 100, 6 (2021))
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  Corrigendum to Mann JFE, Muskiet MHA. Incretin-based drugs and the kidney in type 2 diabetes: choosing between DPP-4 inhibitors and GLP-1 receptor agonists. Kidney Int. 2021;99:314–318 Kidney Int
  For the above-stated “point” article in the Controversies in Nephrology series, the authors regret that in Table 1 in the Renal outcome/endpoints column, for the GLP-1 receptor agonists ELIXA (2015) and EXSCEL (2017), post hoc was mischaracterized as secondary. The correct table appears (...) (Kidney International 100, 6 (2021))
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  When contactin antibodies hit the podocyte: a new neurorenal syndrome - Hanna Debiec, Pierre Ronco Kidney Int
  Membranous nephropathy can be associated with various etiologies and antigens. In this issue of Kidney International, Le Quintrec et al. described contactin-1 cell adhesion molecule as a novel target antigen shared by the peripheral nerve and podocyte in patients with neurological disease and (...) (Kidney International 100, 6 (2021))
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  Erratum to Shankar AS, Du Z, Mora HT, et al. Human kidney organoids produce functional renin. Kidney Int. 2021;99:134–147 Kidney Int
  The publisher regrets that in the above-stated article, the immunochemistry image of angiotensin-converting enzyme 2 positivity was not included in Figure 2e. Figure 2 appears below. (Kidney International 100, 6 (2021))
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  Corrigendum to Heybeli C, Bentall A, Wen J, et al. A study from The Mayo Clinic evaluated long-term outcomes of kidney transplantation in patients with immunoglobulin light chain amyloidosis. Kidney Int. 2021;99:707–715 - Cihan Heybeli, Andrew Bentall, Jiqiu Wen, Mariam Priya Alexander, Francis K. Buadi, Fernando G. Cosio, Patrick G. Dean, Angela Dispenzieri, David Dingli, Mireille El Ters, Morie A. Gertz, Hatem Amer, Prashant Kapoor, Hasan Khamash, Taxiarchis Kourelis, Shaji Kumar, Elizabeth C. Lorenz, Martin Mai, Eli Muchtar, David L. Murray, Mikel Prieto, Carrie A. Schinstock, Mark D. Stegall, Rahma Warsame, Nelson Leung Kidney Int
  The authors regret that in the above-stated article, the given name and surname one of the authors, Hatem Amer, was presented inaccurately. The given name is Hatem and the surname is Amer. (Kidney International 100, 6 (2021))
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  Imlifidase as novel treatment strategy in anti-neutrophil cytoplasmic antibody–induced pulmonary-renal syndrome - Philipp Enghard, Daniel Zickler, Janis Sonnemann, Wolfgang Schneider, Georg Lurje, Sefer Elezkurtaj, Kai-Uwe Eckardt, Adrian Schreiber Kidney Int
  Anti-neutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) is potentially life threatening, but rapidly effective treatment options are still lacking. Herein, we report on the first use of imlifidase in refractory (...) (Kidney International 100, 6 (2021))
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  UMOD-ulating CKD risk: untangling the relationship between urinary uromodulin, blood pressure, and kidney disease - Michael Turner, Natalie Staplin Kidney Int
  A new Mendelian randomization study finds evidence that genetically predicted higher levels of urinary uromodulin are associated with lower kidney function and higher blood pressure. Bidirectional and multivariable Mendelian randomization suggests the association with higher blood pressure (...) (Kidney International 100, 6 (2021))
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  Linking transcription to energy: the path to understand kidney injury - Verónica Miguel, Santiago Lamas Kidney Int
  The metabolic impairment of kidney tubular cells is a key mechanism underlying the pathophysiology of renal fibrosis. In particular, a drastic reduction in fatty acid oxidation is essentially responsible for the global energy failure occurring in the tubulointerstitial compartment. Piret et al. (...) (Kidney International 100, 6 (2021))
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  Role of proteinuria in the anemia of chronic kidney disease - Tilman B. Drüeke, Ziad A. Massy Kidney Int
  The most important contributors to the anemia of patients with chronic kidney disease are insufficient erythropoietin production and erythropoietin hyporesponsiveness, decreased red blood cell half-life, iron deficiency, and inflammation. However, in contrast to the role of kidney failure, that (...) (Kidney International 100, 6 (2021))
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  Management of fluid overload in hemodialysis patients - Tony Lopez, Debasish Banerjee Kidney Int
  Fluid overload is a common and important complication encountered in the care of patients with end-stage kidney failure receiving hemodialysis. Fluid overload not only causes unpleasant symptomatology for patients on dialysis, but also leads to increased incidence of hospitalization and (...) (Kidney International 100, 6 (2021))
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  Contactin-1–associated membranous nephropathy: complete immunologic and clinical remission with rituximab - Emmanuelle Plaisier, Adeline Not, David Buob, Pierre Ronco, Hanna Debiec Kidney Int
  In this issue of Kidney International, Le Quintrec et al.1 identified contactin-1 (CNTN1) as the potential antigen in 5 patients with membranous nephropathy (MN) associated with chronic inflammatory demyelinating polyneuropathy (CIDP). Here, we report the case of an additional patient with this (...) (Kidney International 100, 6 (2021))
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  Antiresorptives in patients with chronic kidney disease with adynamic bone: Is absence of evidence of harm equal to no harm? - Amr El-Husseini, Mahmoud Sobh, Nehal Elshabrawy, Mohamed Abdalbary Kidney Int
  We are impressed with the concept discussed by Haarhaus et al. of using antiresorptives in patients with chronic kidney disease (CKD) with adynamic bone (AB),1 but we need to clarify some concerns. Clinical trials put all patients in 1 group, without stratifying them according to their bone (...) (Kidney International 100, 6 (2021))
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  Unexpected cause of vemurafenib-induced nephrotoxicity: ferrochelatase - Ryo Yamada, Motoko Yanagita Kidney Int
  Among v-raf murine sarcoma viral oncogene homolog B1 inhibitors, vemurafenib causes a higher incidence of nephrotoxicity. Bai et al. reported that vemurafenib-induced nephrotoxicity is not directly caused by viral oncogene homolog B1 inhibition but is partly caused by ferrochelatase inhibition (...) (Kidney International 100, 6 (2021))
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  The Case | A nonhealing skin ulcer in a patient 5 years after successful transplantation - Mira Choi, Anne Krueger, Martina Mogl, Mikai Hsiao, Cornelia Jung, Andreas Pasch, Jakob Voelkl, Kai-Uwe Eckardt, Uwe Hillen Kidney Int
  A 68-year-old man, who had received a kidney transplant 5 years earlier, presented with an extremely painful deep left-thigh ulceration. Four weeks earlier, he had experienced minor traumatic injury, resulting in a hematoma that subsequently ulcerated (Figure 1). At presentation, the ulcer was (...) (Kidney International 100, 6 (2021))
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  Granuloma formation after peritoneal dialysis catheter–related infection by Mycobacterium chelonae - Ryunosuke Noda, Daisuke Kamano, Tatsuki Abe, Satoki Shinzawa, Manabu Takamatsu, Yuan Bae, Ryu Kobayashi, Mai Yanagi, Yoshitaka Ishibashi Kidney Int
  A 46-year-old man with end-stage kidney failure that had been treated with peritoneal dialysis for 5 years was suffering from a tunnel infection. The peritoneal dialysis catheter was removed, and he was converted to hemodialysis. The pathogen obtained from a culture of the outer cuff turned out (...) (Kidney International 100, 6 (2021))
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  Massive renal angiomyolipomas in tuberous sclerosis complex - Grace Y. Chong, Maroun T. Chedid, Theodora A. Potretzke, Fouad T. Chebib Kidney Int
  A 28-year-old woman with tuberous sclerosis complex presented for consideration of debulking surgery of bilateral renal angiomyolipomas (AMLs). Tuberous sclerosis was diagnosed in infancy, and her AMLs enlarged as she grew older. This caused substantial impairment in her quality of life as she (...) (Kidney International 100, 6 (2021))
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  Strawberry gingivitis - Romain Muller, Gaetan Lebrun Kidney Int
  A 38-year-old man presented to the emergency department with acute renal failure. He had a medical history of recurrent sinusitis for 1 year, regularly treated with antibiotics. He was not taking any other treatment. He complained of asthenia, diffuse muscle pain, and arthralgias, affecting (...) (Kidney International 100, 6 (2021))

29 November

Kidney Int http://www.kidney-international.org/

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  Lysophosphatidylcholine mediates fast decline in kidney function in diabetic kidney disease - Kentaro Yoshioka, Yosuke Hirakawa, Makoto Kurano, Yuko Ube, Yoko Ono, Kensuke Kojima, Taiga Iwama, Kuniyuki Kano, Sho Hasegawa, Tsuyoshi Inoue, Takashi Shimada, Junken Aoki, Yutaka Yatomi, Masaomi Nangaku, Reiko Inagi Kidney Int
  Some patients with diabetic kidney disease (DKD) show a fast progression of kidney dysfunction and are known as a "fast decliner" (FD). Therefore, it is critical to understand pathomechanisms specific for fast decline. Here, we performed a comprehensive metabolomic analysis of patients with (...) (Kidney International 101, 3 (2022))
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  A prospective observational study for justification, safety, and efficacy of a third dose of mRNA vaccine in patients receiving maintenance hemodialysis - Maxime Espi, Xavier Charmetant, Thomas Barba, Cyrille Mathieu, Caroline Pelletier, Laetitia Koppe, Elodie Chalencon, Emilie Kalbacher, Virginie Mathias, Anne Ovize, Emmanuelle Cart-Tanneur, Christine Bouz, Laurence Pellegrina, Emmanuel Morelon, Laurent Juillard, Denis Fouque, Cécile Couchoud, Olivier Thaunat, in collaboration with the REIN Registry Kidney Int
  The level of protection achieved by the standard two doses of COVID-19 mRNA vaccines in patients receiving maintenance hemodialysis (MHD) remains unclear. To study this we used the French Renal Epidemiology and Information Network (REIN) Registry to compare the incidence and severity of 1474 (...) (Kidney International 101, 2 (2022))

26 November

Kidney Int http://www.kidney-international.org/

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  Kidney vascular congestion exacerbates acute kidney injury in mice - Takashi Kitani, Kengo Kidokoro, Tomohiro Nakata, Yuhei Kirita, Itaru Nakamura, Kunihiro Nakai, Aya Yagi-Tomita, Tomoharu Ida, Noriko Uehara-Watanabe, Kisho Ikeda, Noriyuki Yamashita, Benjamin D. Humphreys, Naoki Kashihara, Satoaki Matoba, Keiichi Tamagaki, Tetsuro Kusaba Kidney Int
  Heart failure is frequently accompanied by kidney failure and co-incidence of these organ failures worsens the mortality in patients with heart failure. Recent clinical observations revealed that increased kidney venous pressure, rather than decreased cardiac output, causes the deterioration of (...) (Kidney International 101, 3 (2022))

25 November

Kidney Int http://www.kidney-international.org/

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  Extracellular vesicles in kidney transplantation: a state-of-the-art review - James Ashcroft, Philippa Leighton, Tegwen R. Elliott, Sarah A. Hosgood, Michael L. Nicholson, Vasilis Kosmoliaptsis Kidney Int
  Kidney transplantation is the optimal treatment for patients with kidney failure; however, early detection and timely treatment of graft injury remain a challenge. Precise and noninvasive techniques of graft assessment and innovative therapeutics are required to improve kidney transplantation (...) (Kidney International 101, 3 (2022))
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  Role of the macula densa sodium glucose cotransporter type 1-neuronal nitric oxide synthase-tubuloglomerular feedback pathway in diabetic hyperfiltration - Jie Zhang, Jing Cai, Yu Cui, Shan Jiang, Jin Wei, Young Chul Kim, Jenna Chan, Anish Thalakola, Thanh Le, Lan Xu, Lei Wang, Kun Jiang, Ximing Wang, Haibo Wang, Feng Cheng, Jacentha Buggs, Hermann Koepsell, Volker Vallon, Ruisheng Liu Kidney Int
  An increase of glomerular filtration rate (GFR) is a common observation in early diabetes and is considered a key risk factor for subsequent kidney injury. However, the mechanisms underlying diabetic hyperfiltration have not been fully clarified. Here, we tested the hypothesis that macula densa (...) (Kidney International 101, 3 (2022))
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  A metabolomics approach identified toxins associated with uremic symptoms in advanced chronic kidney disease - Jiun-Ruey Hu, Leslie Myint, Andrew S. Levey, Josef Coresh, Lesley A. Inker, Morgan E. Grams, Eliseo Guallar, Kasper D. Hansen, Eugene P. Rhee, Tariq Shafi Kidney Int
  Uremic symptoms are common in patients with advanced chronic kidney disease, but the toxins that cause these symptoms are unknown. To evaluate this, we performed a cross-sectional study of the 12 month post-randomization follow-up visit of Modification of Diet in Renal Disease (MDRD) (...) (Kidney International 101, 2 (2022))

24 November

Kidney Int http://www.kidney-international.org/

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  Enteral ferric citrate absorption is dependent on the iron transport protein ferroportin - Mark R. Hanudel, Brian Czaya, Shirley Wong, Maxime Rappaport, Shweta Namjoshi, Kristine Chua, Grace Jung, Victoria Gabayan, Bo Qiao, Elizabeta Nemeth, Tomas Ganz Kidney Int
  Ferric citrate is approved as an iron replacement product in patients with non-dialysis chronic kidney disease and iron deficiency anemia. Ferric citrate-delivered iron is enterally absorbed, but the specific mechanisms involved have not been evaluated, including the possibilities of (...) (Kidney International 101, 4 (2022))
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  Dysfunction of the circadian clock in the kidney tubule leads to enhanced kidney gluconeogenesis and exacerbated hyperglycemia in diabetes - Camille Ansermet, Gabriel Centeno, Yohan Bignon, Daniel Ortiz, Sylvain Pradervand, Andy Garcia, Laure Menin, Frédéric Gachon, Hikari AI. Yoshihara, Dmitri Firsov Kidney Int
  The circadian clock is a ubiquitous molecular time-keeping mechanism which synchronizes cellular, tissue, and systemic biological functions with 24-hour environmental cycles. Local circadian clocks drive cell type- and tissue-specific rhythms and their dysregulation has been implicated in (...) (Kidney International 101, 3 (2022))

23 November

Kidney Int http://www.kidney-international.org/

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  GLP-1 receptor agonist versus DPP-4 inhibitor and kidney and cardiovascular outcomes in clinical practice in type-2 diabetes - Yang Xu, Edouard L. Fu, Catherine M. Clase, Faizan Mazhar, Meg J. Jardine, Juan J. Carrero Kidney Int
  Whether glucagon-like peptide-1 receptor agonists (GLP1-RA) reduce detrimental kidney outcomes is uncertain. In secondary analyses, trials have shown consistent reductions in macroalbuminuria, but inconclusive results about kidney function decline. To help clarify this, we conducted a cohort (...) (Kidney International 101, 2 (2022))

21 November

Kidney Int http://www.kidney-international.org/

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  Distinct glomerular disease association after vaccination with BNT162b2 and mRNA-1273: a VigiBase analysis - Andreas Kronbichler, Se Yong Jung, Min Seo Kim, Jae Il Shin Kidney Int
  With the worldwide rollout of coronavirus disease 2019 (COVID-19) vaccines, numerous reports of de novo or relapsing glomerular diseases have been published recently.1–4 It has been stressed that associations between vaccination efforts and the onset of disease do not prove causation, but the (...) (Kidney International 101, 2 (2022))
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  Antibody response to COVID-19 booster vaccine in rituximab-treated patients with anti–neutrophil cytoplasmic antibody–associated vasculitis - Sam Kant, Antoine Azar, Duvuru Geetha Kidney Int
  The success of the infectious coronavirus disease 2019 (COVID-19) vaccine has been accompanied by challenges, which include suboptimal response in patients on immunosuppression. Although booster doses of the vaccine have led to an increment in the number of patients (solid organ transplant (...) (Kidney International 101, 2 (2022))

20 November

Kidney Int http://www.kidney-international.org/

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  Expression of concern from the KI Editors: “Apolipoprotein-1 risk variants and associated kidney phenotypes in an adult HIV cohort in Nigeria” [Kidney International, July 2021, Pages 146–154] and “APOL1-associated kidney disease in northern Nigerians with treated HIV infection” [Kidney International, July 2021, Pages 19–21] Kidney Int
  The Editors of Kidney International (KI) are releasing this Expression of Concern for 2 articles that were recently published in KI. In July 2021, KI published a study on phenotypes associated with APOL1 kidney disease risk variants (KRVs) in an adult HIV cohort in Nigeria.1 This (...) (Kidney International 101, 1 (2022))

12 November

Kidney Int http://www.kidney-international.org/

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  Multidisciplinary approaches for elucidating genetics and molecular pathogenesis of urinary tract malformations - Kamal Khan, Dina F. Ahram, Yangfan P. Liu, Rik Westland, Rosemary V. Sampogna, Nicholas Katsanis, Erica E. Davis, Simone Sanna-Cherchi Kidney Int
  Advances in clinical diagnostics and molecular tools have improved our understanding of the genetically heterogeneous causes underlying congenital anomalies of kidney and urinary tract (CAKUT). However, despite a sharp incline of CAKUT reports in the literature within the past 2 decades, there (...) (Kidney International 101, 3 (2022))

10 November

Kidney Int http://www.kidney-international.org/

• 00:00
  How the amyloid fibril has unraveled: lessons for nephrology - Nelson Leung Kidney Int
  I still remember my first amyloid patient. I was on call as a medical intern when a patient was admitted with severe heart and kidney failure and the largest liver I had seen at the time. I recall wondering how a single disease could affect so many different organs. More urgently, who should I (...) (Kidney International 101, 4 (2022))
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  A novel model of nephrotic syndrome results from a point mutation in Lama5 and is modified by genetic background - Sara Falcone, Thomas Nicol, Andrew Blease, Michael J. Randles, Elizabeth Angus, Anton Page, Frederick W.K. Tam, Charles D. Pusey, Rachel Lennon, Paul K. Potter Kidney Int
  Nephrotic syndrome is characterized by severe proteinuria, hypoalbuminaemia, edema and hyperlipidaemia. Genetic studies of nephrotic syndrome have led to the identification of proteins playing a crucial role in slit diaphragm signaling, regulation of actin cytoskeleton dynamics and cell-matrix (...) (Kidney International 101, 3 (2022))
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  Altered vitamin K biodistribution and metabolism in experimental and human chronic kidney disease - Nadine Kaesler, Felix Schreibing, Thimoteus Speer, Sofia de la Puente-Secades, Nikolas Rapp, Christiane Drechsler, Nazanin Kabgani, Christoph Kuppe, Peter Boor, Vera Jankowski, Leon Schurgers, Rafael Kramann, Jürgen Floege Kidney Int
  Chronic kidney disease (CKD) is accompanied with extensive cardiovascular calcification, in part correlating with functional vitamin K deficiency. Here, we sought to determine causes for vitamin K deficiency beyond reduced dietary intake. Initially, vitamin K uptake and distribution into (...) (Kidney International 101, 2 (2022))
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  Dephosphorylation of AMP-activated protein kinase exacerbates ischemia/reperfusion-induced acute kidney injury via mitochondrial dysfunction - Haijian Ma, Xiaozhen Guo, Shichao Cui, Yongmei Wu, Yangming Zhang, Xiaoyan Shen, Cen Xie, Jingya Li Kidney Int
  Kidney tubular epithelial cells are high energy-consuming epithelial cells that depend mainly on fatty acid oxidation for an energy supply. AMP-activated protein kinase (AMPK) is a key regulator of energy production in most cells, but the function of AMPK in tubular epithelial cells in acute (...) (Kidney International 101, 2 (2022))
• 00:00
  A systematic review and meta-analysis of murine models of uremic cardiomyopathy - Josefin Soppert, Janina Frisch, Julia Wirth, Christian Hemmers, Peter Boor, Rafael Kramann, Sonja Vondenhoff, Julia Moellmann, Michael Lehrke, Mathias Hohl, Emiel P.C. van der Vorst, Christian Werner, Thimoteus Speer, Christoph Maack, Nikolaus Marx, Joachim Jankowski, Leticia Prates Roma, Heidi Noels Kidney Int
  Chronic kidney disease (CKD) triggers the risk of developing uremic cardiomyopathy as characterized by cardiac hypertrophy, fibrosis and functional impairment. Traditionally, animal studies are used to reveal the underlying pathological mechanism, although variable CKD models, mouse strains and (...) (Kidney International 101, 2 (2022))
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  A multiple 24-hour urine collection study indicates that kidney function decline is related to urinary sodium and potassium excretion in patients with chronic kidney disease - Soshiro Ogata, Yuumi Akashi, Takaya Sakusabe, Shigehito Yoshizaki, Yuko Maeda, Kunihiro Nishimura, Kenji Maeda, Shigeru Nakai Kidney Int
  Multiple 24-hour urine collections are necessary to adequately assess sodium and potassium intake. Here, we assessed kidney function decline for four years after baseline in relation to seven-time averaged 24-hour urinary sodium and potassium excretion (UNaV, UKV), their UNaV/UKV ratio, and (...) (Kidney International 101, 1 (2022))
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  Myeloid cyclooxygenase-2/prostaglandin E2/E-type prostanoid receptor 4 promotes transcription factor MafB-dependent inflammatory resolution in acute kidney injury - Yu Pan, Shirong Cao, Andrew S. Terker, Jiaqi Tang, Kensuke Sasaki, Yinqiu Wang, Aolei Niu, Wentian Luo, Xiaofeng Fan, Suwan Wang, Matthew H. Wilson, Ming-Zhi Zhang, Raymond C. Harris Kidney Int
  Following acute injury to the kidney, macrophages play an important role in recovery of functional and structural integrity, but organ fibrosis and progressive functional decline occur with incomplete recovery. Pro-resolving macrophages are characterized by increased cyclooxygenase 2 (COX-2) (...) (Kidney International 101, 1 (2022))
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  Metabolome-wide association study of estimated glomerular filtration rates in Hispanics - Bridget M. Lin, Ying Zhang, Bing Yu, Eric Boerwinkle, Bharat Thygarajan, Milagros Yunes, Martha L. Daviglus, Qibin Qi, Robert Kaplan, James Lash, Jianwen Cai, Tamar Sofer, Nora Franceschini Kidney Int
  Circulating metabolites are by-products of endogenous metabolism or exogenous sources and may inform disease states. Our study aimed to identify the source of variability in the association of metabolites with estimated glomerular filtration rate (eGFR) in Hispanics/Latinos with low chronic (...) (Kidney International 101, 1 (2022))

9 November

Kidney Int http://www.kidney-international.org/

• 00:00
  Mapping GWAS loci to kidney genes and cell types - Katherine Xu, Krzysztof Kiryluk Kidney Int
  Estimated glomerular filtration rate (eGFR) has significant heritability, varying from 36% to 75% in different studies.1,2 Genome-wide association studies (GWAS) have now identified over 400 significant loci for eGFR, most of which map to noncoding regions.3,4 A major challenge for the field is (...) (Kidney International 101, 3 (2022))
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  Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease - Vera Jankowski, Turgay Saritas, Mads Kjolby, Juliane Hermann, Thimoteus Speer, Anika Himmelsbach, Kerstin Mahr, Marina Augusto Heuschkel, Stefan J. Schunk, Soren Thirup, Simon Winther, Morten Bottcher, Mette Nyegard, Anders Nykjaer, Rafael Kramann, Nadine Kaesler, Joachim Jankowski, Juergen Floege, Nikolaus Marx, Claudia Goettsch Kidney Int
  Sortilin, an intracellular sorting receptor, has been identified as a cardiovascular risk factor in the general population. Patients with chronic kidney disease (CKD) are highly susceptible to develop cardiovascular complications such as calcification. However, specific CKD-induced (...) (Kidney International 101, 3 (2022))
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  Modulation of transforming growth factor-?-induced kidney fibrosis by leucine-rich ?-2 glycoprotein-1 - Quan Hong, Hong Cai, Lu Zhang, Zhengzhe Li, Fang Zhong, Zhaohui Ni, Guangyan Cai, Xiang-Mei Chen, John Cijiang He, Kyung Lee Kidney Int
  Kidney fibrosis is considered the final convergent pathway for progressive chronic kidney diseases, but there is still a paucity of success in clinical application for effective therapy. We recently demonstrated that the expression of secreted leucine-rich ?-2 glycoprotein-1 (LRG1) is associated (...) (Kidney International 101, 2 (2022))
• 00:00
  RNA-based immunoglobulin repertoire sequencing is a new tool for the management of monoclonal gammopathy of renal (kidney) significance - Vincent Javaugue, Virginie Pascal, Sébastien Bender, Sarah Nasraddine, Mathilde Dargelos, Mehdi Alizadeh, Alexis Saintamand, Matthieu Filloux, Paco Derouault, Sabrina Bouyer, Estelle Desport, Arnaud Jaccard, Frank Bridoux, Michel Cogné, Christophe Sirac Kidney Int
  The diagnostic approach of monoclonal gammopathy of renal significance is based on the detection of a monoclonal immunoglobulin in the blood and urine, and the identification of the underlying clone through bone marrow and/or peripheral blood cytologic and flow cytometry analysis. However, the (...) (Kidney International 101, 2 (2022))
• 00:00
  The characteristics of patients with kidney light chain deposition disease concurrent with light chain amyloidosis - Samar M. Said, Alejandro Best Rocha, Anthony M. Valeri, Paisit Paueksakon, Surendra Dasari, Jason D. Theis, Julie A. Vrana, Modupe O. Obadina, Darius Saghafi, Mariam Priya Alexander, Sanjeev Sethi, Christopher P. Larsen, Florent Joly, Angela Dispenzieri, Frank Bridoux, Christophe Sirac, Nelson Leung, Agnes B. Fogo, Ellen D. McPhail, Samih H. Nasr Kidney Int
  The type of monoclonal light chain nephropathy is thought to be largely a function of the structural and physiochemical properties of light chains; hence most affected patients have only one light chain kidney disease type. Here, we report the first series of kidney light chain deposition (...) (Kidney International 101, 1 (2022))
• 00:00
  Gene expression changes related to bone mineralization, blood pressure and lipid metabolism in mouse kidneys after space travel - Norio Suzuki, Yuma Iwamura, Taku Nakai, Koichiro Kato, Akihito Otsuki, Akira Uruno, Daisuke Saigusa, Keiko Taguchi, Mikiko Suzuki, Ritsuko Shimizu, Akane Yumoto, Risa Okada, Masaki Shirakawa, Dai Shiba, Satoru Takahashi, Takafumi Suzuki, Masayuki Yamamoto Kidney Int
  Space travel burdens health by imposing considerable environmental stress associated with radioactivity and microgravity. In particular, gravity change predominantly impacts blood pressure and bone homeostasis, both of which are controlled mainly by the kidneys. Nuclear factor (...) (Kidney International 101, 1 (2022))

1 November

Kidney Int http://www.kidney-international.org/

• 00:00
  Uremic encephalopathy - Mitchell H. Rosner, Faeq Husain-Syed, Thiago Reis, Claudio Ronco, Raymond Vanholder Kidney Int
  Uremic encephalopathy encompasses a wide range of central nervous system abnormalities associated with poor kidney function occurring with either progressive chronic kidney disease or acute kidney injury. The syndrome is likely caused by retention of uremic solutes, alterations in hormonal (...) (Kidney International 101, 2 (2022))
• 00:00
  In vivo evidence for therapeutic applications of beclin 1 to promote recovery and inhibit fibrosis after acute kidney injury - Mingjun Shi, Jenny Maique, Sierra Shepard, Peng Li, Olivia Seli, Orson W. Moe, Ming Chang Hu Kidney Int
  Autophagy regulator beclin 1 activity determines the severity of kidney damage induced by ischemia reperfusion injury, but its role in kidney recovery and fibrosis are unknown and its therapeutic potentials have not been tested. Here, we explored beclin 1 effects on kidney fibrosis in three (...) (Kidney International 101, 1 (2022))
• 00:00
  National and international kidney failure registries: characteristics, commonalities, and contrasts - Monica S.Y. Ng, Vivek Charu, David W. Johnson, Michelle M. O’Shaughnessy, Andrew J. Mallett Kidney Int
  Registries are essential for health infrastructure planning, benchmarking, continuous quality improvement, hypothesis generation, and real-world trials. To date, data from these registries have predominantly been analyzed in isolated “silos,” hampering efforts to analyze “big data” at the (...) (Kidney International 101, 1 (2022))
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  Table of Contents Kidney Int
  (Kidney International 100, 5 (2021))
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  Subscription Information Kidney Int
  (Kidney International 100, 5 (2021))
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  Editorial Board Kidney Int
  (Kidney International 100, 5 (2021))
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  In this issue Kidney Int
  Nephronophthisis (NPH) is a hereditary ciliopathy and an important cause of end-stage kidney disease. Homozygous deletion of the NPHP1 gene is the most common cause of NPH. The protein product of NPHP1 is nephrocystin 1, and in addition to the kidney, it is found in the photoreceptors of the (...) (Kidney International 100, 5 (2021))
• 00:00
  Journal Club Kidney Int
  Son et al. ([e-pub ahead of print] J Clin Invest. https://doi.org/10.1172/JCI146771. Accessed September 8, 2021.) (Kidney International 100, 5 (2021))
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  Telomere length and chronic kidney disease: cause or consequence? - Florian Kronenberg Kidney Int
  Telomere length is considered as a clock mirroring aging and is influenced by oxidative stress and inflammation. Both conditions are highly prevalent in patients with chronic kidney disease and other degenerative disorders, such as cardiovascular disease. However, it is discussed (...) (Kidney International 100, 5 (2021))
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  Urinary Dickkopf-3 and kidney injury in patients with chronic pulmonary disease - Stefanie Thöni, Gert Mayer Kidney Int
  Dickkopf-related protein 3 is a stress-induced, epithelial cell–derived glycoprotein that is promoted as a prognostic as well as a predictive urinary biomarker in acute and chronic kidney disease. Schunk et al. provided evidence that Dickkopf-related protein 3 identifies patients with chronic (...) (Kidney International 100, 5 (2021))
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  Jury still out on whether FGF23 is a direct contributor, a useful biomarker, or neither - Hirotaka Komaba, Masafumi Fukagawa Kidney Int
  Fibroblast growth factor 23 (FGF23) is an endocrine hormone that is mainly produced by osteocytes. In patients with chronic kidney disease (CKD), circulating FGF23 levels increase as kidney function declines. This helps maintain normal phosphate balance by enhancing urinary phosphate excretion. (...) (Kidney International 100, 5 (2021))
• 00:00
  Role of FGF23 in clinical outcomes of patients with chronic kidney disease - Tilman B. Drüeke Kidney Int
  Mutations and overexpression of the hormone fibroblast growth factor 23 (FGF23) were discovered 20 years ago as the cause of autosomal dominant hypophosphatemic rickets and tumor-induced osteomalacia, respectively. Subsequently, numerous studies first demonstrated the role of FGF23 in (...) (Kidney International 100, 5 (2021))
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  Fibroblast growth factor 23, the time is right for a second wind - Marc Vervloet Kidney Int
  Like many novel discoveries, the recognition of a clinically relevant role of fibroblast growth factor 23 (FGF23) in nephrology was welcomed with almost untamed enthusiasm. Indeed, initial findings were stunning on several levels. First, the rise of circulating FGF23, as chronic kidney disease (...) (Kidney International 100, 5 (2021))
• 00:00
  The authors reply: - Junjiong Zheng, Hao Yu, Zhuo Wu, Xiaoguang Zou, Tianxin Lin Kidney Int
  We thank Zhang et al.1 for their interest in our study.2 Usually, feature reproducibility assessment is implemented for data dimension reduction. However, because the margins of a urinary stone in computed tomography images are clear, satisfactory interobserver feature extraction (...) (Kidney International 100, 5 (2021))
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  A machine learning–based radiomic model for predicting urinary infection stone - Lu Zhang, Bin Zhang Kidney Int
  We read with great interest the article by Zheng et al.,1 published in Kidney International. This study leveraged a noninvasive radiomic model to preoperatively predict infection stones. Despite the encouraging results, several methodological issues should be noted. A robust radiomic biomarker (...) (Kidney International 100, 5 (2021))
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  Gains in understanding of podocyte loss - Agnes B. Fogo Kidney Int
  Podocyte loss is a key element underlying glomerulosclerosis. Various mechanisms have been proposed for cell loss. These include local hemodynamic effects and local stresses on cell and hemodynamic changes, which together may contribute to detachment of podocytes, leading to sclerosis. Elegant (...) (Kidney International 100, 5 (2021))
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  Ketone bodies: back to a place in the sun - Shinji Kume Kidney Int
  Ketone bodies have a strong negative image in medicine because of ketoacidosis, a life-threatening complication in diabetes. However, Fang et al. report that ketone bodies exert antisenescent effects in podocytes under diabetic conditions, via activation of the nuclear factor E2-related factor (...) (Kidney International 100, 5 (2021))
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  Point-of-care Doppler ultrasonography: a new dimension to kidney imaging - Abhilash Koratala, Amir Kazory Kidney Int
  We read with great interest the article by Caroli et al., in which they meticulously discuss the role of imaging in elucidating both structural and functional aspects of kidney disease.1 Herein, we would like to briefly comment on evaluation of renal venous congestion in clinical practice. (...) (Kidney International 100, 5 (2021))
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  The Case | Unexplained inflammation after treatment for granulomatosis with polyangiitis - Heidy Hendra, Viyaasan Mahalingasivam, Alan D. Salama, Aine Burns Kidney Int
  A 64-year-old man with granulomatosis with polyangiitis (GPA) reported feeling “below par.” Almost 2 years earlier, he had presented with nasal crusting, epistaxis, deafness, weight loss, night sweats, and nonvisible hematuria. No baseline imaging was performed. Cytoplasmic anti-neutrophil (...) (Kidney International 100, 5 (2021))
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  Ultrasound findings of calciphylaxis - Raphael J. Rosen, Hilda E. Fernandez, Shayan Shirazian, Andrew A. Moses Kidney Int
  A 67-year-old woman with end-stage kidney disease on peritoneal dialysis, with diabetes, with atrial fibrillation treated with warfarin, and with Sjogren syndrome presented with firm subcutaneous nodules on her thighs and a large exquisitely tender erythematous lesion on her abdomen with a (...) (Kidney International 100, 5 (2021))
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  Unilateral nephrocalcinosis - Aghilès Hamroun, Frederic Brioude, Arnaud Lionet Kidney Int
  A 37-year-old man with unremarkable medical history was referred to our nephrology department for unilateral left nephrocalcinosis, incidentally discovered on imaging for chronic low back pain (Figure 1, arrow). On clinical examination, we were struck by a lateralized overgrowth of the left (...) (Kidney International 100, 5 (2021))
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  Acute renal cortical necrosis: cortical rim sign and reverse rim sign - Chandra Bhushan Prasad, Rakavi Rathinasamy, Chirag Rajkumar Kopp, Siddharth Jain, Sanjay Jain, Varun Dhir Kidney Int
  A 35-year-old primigravida, with an uneventful antenatal course, presented with anuria and high-grade fever for 4 days after an emergency caesarean section at 37 weeks, done because of oligohydramnios and fetal distress. On presentation, she was febrile and had anasarca and basal crepitations (...) (Kidney International 100, 5 (2021))

29 October

Kidney Int http://www.kidney-international.org/

• 00:00
  Non-HLA antibodies targeting angiotensin II Type 1 receptor and endothelin-1 Type A receptors induce endothelial injury via ?2-arrestin link to mTOR pathway - Rusan Ali Catar, Oskar Wischnewski, Lei Chen, Harald Heidecke, Claudia Rutz, Ralf Schülein, Duska Dragun, Aurélie Philippe, Angelika Kusch Kidney Int
  Functional non-HLA antibodies (antibodies to non-human leukocyte antigens) targeting the G protein-coupled receptors angiotensin II type 1 receptor (AT1R) and endothelin-1 type A receptor (ETAR) are implicated in the pathogenesis of transplant vasculopathy. While ERK signaling (a regulator of (...) (Kidney International 101, 3 (2022))
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  Deep learning identified pathological abnormalities predictive of graft loss in kidney transplant biopsies - Zhengzi Yi, Fadi Salem, Madhav C. Menon, Karen Keung, Caixia Xi, Sebastian Hultin, M. Rizwan Haroon Al Rasheed, Li Li, Fei Su, Zeguo Sun, Chengguo Wei, Weiqing Huang, Samuel Fredericks, Qisheng Lin, Khadija Banu, Germaine Wong, Natasha M. Rogers, Samira Farouk, Paolo Cravedi, Meena Shingde, R. Neal Smith, Ivy A. Rosales, Philip J. O’Connell, Robert B. Colvin, Barbara Murphy, Weijia Zhang Kidney Int
  Interstitial fibrosis, tubular atrophy, and inflammation are major contributors to kidney allograft failure. Here we sought an objective, quantitative pathological assessment of these lesions to improve predictive utility and constructed a deep-learning–based pipeline recognizing normal vs. (...) (Kidney International 101, 2 (2022))
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  The cell membrane repair protein MG53 modulates transcription factor NF-?B signaling to control kidney fibrosis - Haichang Li, Pu Duann, Zhongguang Li, Xinyu Zhou, Jianjie Ma, Brad H. Rovin, Pei-Hui Lin Kidney Int
  Kidney fibrosis is associated with the progression of acute kidney injury to chronic kidney disease. MG53, a cell membrane repair protein, has been shown to protect against injury to kidney epithelial cells and acute kidney injury. Here, we evaluated the role of MG53 in modulation of kidney (...) (Kidney International 101, 1 (2022))
• 00:00
  Diagnosis and treatment of arterial hypertension 2021 - Christian Ott, Roland E. Schmieder Kidney Int
  In the last 4 years, several evidence-based, national, and international guidelines on the management of arterial hypertension have been published, mostly with concordant recommendations, but in some aspects with discordant opinions. This in-depth review takes these guidelines into account but (...) (Kidney International 101, 1 (2022))

28 October

Kidney Int http://www.kidney-international.org/

• 00:00
  “ADPKD-omics”: determinants of cyclic AMP levels in renal epithelial cells - Yash R. Mehta, Spencer A. Lewis, Kirby T. Leo, Lihe Chen, Euijung Park, Viswanathan Raghuram, Chung-Lin Chou, Chin-Rang Yang, Hiroaki Kikuchi, Syed Khundmiri, Brian G. Poll, Mark A. Knepper Kidney Int
  The regulation of cyclic adenosine monophosphate (cAMP) levels in kidney epithelial cells is important in at least 2 groups of disorders, namely water balance disorders and autosomal dominant polycystic kidney disease. Focusing on the latter, we review genes that code for proteins that are (...) (Kidney International 101, 1 (2022))

27 October

Kidney Int http://www.kidney-international.org/

• 00:00
  Untangling the fibers of sarcopenia: activin A in chronic kidney disease–associated muscle wasting - Andrew S. Terker, T. Alp Ikizler Kidney Int
  Skeletal muscle abnormalities, including sarcopenia, are commonly seen in patients with moderate to advanced chronic kidney disease (CKD). Patients with CKD and coexisting sarcopenia have increased mortality along with decreased quality of life, increased frailty scores, and reduced physical (...) (Kidney International 101, 2 (2022))
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  Soluble CD89 is a critical factor for mesangial proliferation in childhood IgA nephropathy - Alexandra Cambier, Patrick J. Gleeson, Lilia Abbad, Fanny Canesi, Jennifer da Silva, Julie Bex-Coudrat, Georges Deschênes, Olivia Boyer, Marion Rabant, Tim Ulinski, Julien Hogan, Michel Peuchmaur, Laureline Berthelot, Renato C. Monteiro Kidney Int
  Childhood IgA nephropathy (IgAN) includes a wide spectrum of clinical presentations, from isolated hematuria to acute nephritis with rapid loss of kidney function. In adults, IgAN is an autoimmune disease and its pathogenesis involves galactose deficient (Gd) IgA1, IgG anti-Gd-IgA1 (...) (Kidney International 101, 2 (2022))

19 October

Kidney Int http://www.kidney-international.org/

• 00:00
  Addressing the nephrology workforce shortage via a novel undergraduate pipeline program: the Kidney Disease Screening and Awareness Program (KDSAP) at 10 years - Ming-Yan Jiang, Rui Song, Rebecca Chen, Andrew Cho, Sirine Bellou, Min Zhuo, Jiahua Li, Edward Krupat, Suraj Sarvode Mothi, Kavya Shah, Jeremy Policht, Andrew Rosenblatt, Jeffrey Berns, Delphine S. Tuot, Michael Heung, Li-Li Hsiao Kidney Int
  Shortages in the nephrology workforce have threatened the access and quality of health care delivered to the growing population of individuals with kidney disease globally, including in the United States.1 Although the workforce demand is expanding, interest in nephrology as a career choice has (...) (Kidney International 100, 6 (2021))

15 October

Kidney Int http://www.kidney-international.org/

• 00:00
  Lipoic acid supplementation associated with neural epidermal growth factor-like 1 (NELL1)–associated membranous nephropathy - Rebecca I. Spain, Nicole K. Andeen, Pamela C. Gibson, Mary H. Samuels, Cynthia D. Morris, Andrew J. Solomon, Richard Solomon, Carin Waslo, Rupali S. Avasare Kidney Int
  Lipoic acid (alpha lipoic acid, thioctic acid) is a popular over-the-counter antioxidant and insulin-mimetic supplement under investigation in a variety of conditions including multiple sclerosis, diabetes, and schizophrenia. Unfortunately, high-grade proteinuria was an unexpected adverse event (...) (Kidney International 100, 6 (2021))

14 October

Kidney Int http://www.kidney-international.org/

• 00:00
  Waning humoral response 6 months after SARS-CoV-2 vaccination with the mRNA-BNT162b2 vaccine in hemodialysis patients: time for a boost - Tamara Davidovic, Judith Schimpf, Armin Abbassi-Nik, Richard Stockinger, Hannelore Sprenger-Mähr, Karl Lhotta, Emanuel Zitt Kidney Int
  We and others have found a high short-term seroconversion rate between 71% and 98% in hemodialysis patients following a complete 2-dose vaccination course with the mRNA-BNT162b2 vaccine (Pfizer–BioNTech).1,2 After natural infection, 76% of hemodialysis patients remained seropositive after a (...) (Kidney International 100, 6 (2021))

12 October

Kidney Int http://www.kidney-international.org/

• 00:00
  A key gene in Drosophila eye development provides protection for tubules and glomeruli upon injury - Lisa Turinsky, Fabiola Terzi Kidney Int
  Dachshund homolog 1 (DACH1) is highly expressed in both the developing kidney, where it has a role in kidney development, and in the adult kidney, where we know very little about its function. Recently, 2 groups independently reported that DACH1 protects podocytes1 and tubules2 from (...) (Kidney International 101, 1 (2022))

8 October

Kidney Int http://www.kidney-international.org/

• 00:00
  Mendelian randomization to assess causality between uromodulin, blood pressure and chronic kidney disease - Belen Ponte, Marie C. Sadler, Eric Olinger, Peter Vollenweider, Murielle Bochud, Sandosh Padmanabhan, Caroline Hayward, Zoltán Kutalik, Olivier Devuyst Kidney Int
  UMOD variants associated with higher levels of urinary uromodulin (uUMOD) increase the risk of chronic kidney disease (CKD) and hypertension. However, uUMOD levels also reflect functional kidney tubular mass in observational studies, questioning the causal link between uromodulin production and (...) (Kidney International 100, 6 (2021))
• 00:00
  Loss of proximal tubular transcription factor Krüppel-like factor 15 exacerbates kidney injury through loss of fatty acid oxidation - Sian E. Piret, Ahmed A. Attallah, Xiangchen Gu, Yiqing Guo, Nehaben A. Gujarati, Justina Henein, Amy Zollman, Takashi Hato, Avi Ma’ayan, Monica P. Revelo, Kathleen G. Dickman, Chung-Hsin Chen, Chia-Tung Shun, Thomas A. Rosenquist, John C. He, Sandeep K. Mallipattu Kidney Int
  Loss of fatty acid ?-oxidation (FAO) in the proximal tubule is a critical mediator of acute kidney injury and eventual fibrosis. However, transcriptional mediators of FAO in proximal tubule injury remain understudied. Krüppel-like factor 15 (KLF15), a highly enriched zinc-finger transcription (...) (Kidney International 100, 6 (2021))

4 October

Kidney Int http://www.kidney-international.org/

• 00:00
  Ultrasound renal denervation for hypertension: impact of the RADIANCE-HTN-TRIO trial on future management of resistant hypertension - Fernando Elijovich Kidney Int
  A role for excess sympathetic nervous system activity in the pathogenesis of hypertension was already known in the 1930s, when Smithwick developed radical lumbodorsal splanchnicectomy for the management of untreatable, commonly fatal hypertension.1 This technique lowered blood pressure (BP) (...) (Kidney International 101, 1 (2022))
• 00:00
  Highly multiplexed immunofluorescence of the human kidney using co-detection by indexing - Elizabeth K. Neumann, Nathan Heath Patterson, Emilio S. Rivera, Jamie L. Allen, Maya Brewer, Mark P. deCaestecker, Richard M. Caprioli, Agnes B. Fogo, Jeffrey M. Spraggins Kidney Int
  The human kidney is composed of many cell types that vary in their abundance and distribution from normal to diseased organ. As these cell types perform unique and essential functions, it is important to confidently label each within a single tissue to accurately assess tissue architecture and (...) (Kidney International 101, 1 (2022))
• 00:00
  Improved cellular and humoral immunity upon a second BNT162b2 and mRNA-1273 boost in prime-boost vaccination no/low responders with end-stage renal disease - Ulrik Stervbo, Arturo Blazquez-Navarro, Elena Vidal Blanco, Lema Safi, Toni L. Meister, Krystallenia Paniskaki, Mara Stockhausen, Corinna Marheinecke, Gert Zimmer, Jacqueline Wellenkötter, Tina Giglio, Prerna Arora, Stefan Pöhlmann, Markus Hoffmann, Felix S. Seibert, Stephanie Pfaender, Toralf Roch, Timm H. Westhoff, Okan Cinkilic, Nina Babel Kidney Int
  Patients with end-stage renal disease (ESRD) develop inefficient immune responses upon vaccination and have a high risk of developing severe coronavirus disease 2019 (COVID-19). The globally expanding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VOC), (...) (Kidney International 100, 6 (2021))
• 00:00
  Antibody and T-cell response to a third dose of SARS-CoV-2 mRNA BNT162b2 vaccine in kidney transplant recipients - Dominique Bertrand, Mouad Hamzaoui, Veronique Lemée, Julie Lamulle, Charlotte Laurent, Isabelle Etienne, Mathilde Lemoine, Ludivine Lebourg, Mélanie Hanoy, Frank Le Roy, Dorian Nezam, Fabienne Farce, Jean-Christophe Plantier, Olivier Boyer, Dominique Guerrot, Sophie Candon Kidney Int
  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination has become the standard of care for the prevention of severe coronavirus disease 2019 (COVID-19), with a strongly positive impact in countries in which vaccination has been effectively promoted.S1 In kidney transplant (...) (Kidney International 100, 6 (2021))
• 00:00
  Kidney toxicity of phosphate: is that crystal clear yet? - Emmanuel Letavernier, Tilman B. Drüeke Kidney Int
  Hyperphosphatemia is a well-known feature of advanced chronic kidney disease (CKD) and a major risk factor for cardiovascular events in patients with CKD, inducing calcium phosphate supersaturation and vascular calcifications.1 Although the serum phosphate level is not recognized as an (...) (Kidney International 100, 6 (2021))

3 October

Kidney Int http://www.kidney-international.org/

• 00:00
  The lupus nephritis management renaissance - Juan M. Mejia-Vilet, Ana Malvar, Arnon Arazi, Brad H. Rovin Kidney Int
  Over the past year, and for the first time ever, the US Food and Drug Administration approved 2 drugs specifically for the treatment of lupus nephritis (LN). As the lupus community works toward understanding how to best use these new therapies, it is also an ideal time to begin to rethink the (...) (Kidney International 101, 2 (2022))

30 September

Kidney Int http://www.kidney-international.org/

• 00:00
  Anticoagulation in patients with kidney failure on dialysis: factor XI as a therapeutic target - John Eikelboom, Jürgen Floege, Ravi Thadhani, Jeffrey I. Weitz, Wolfgang C. Winkelmayer Kidney Int
  Chronic kidney disease is present in almost 10% of the world population and is associated with excess mortality and morbidity. Reduced glomerular filtration rate and the presence and extent of proteinuria, key domains of chronic kidney disease, have both been shown to be strong and independent (...) (Kidney International 100, 6 (2021))
• 00:00
  Contactin-1 is a novel target antigen in membranous nephropathy associated with chronic inflammatory demyelinating polyneuropathy - Moglie Le Quintrec, Maxime Teisseyre, Nicole Bec, Emilien Delmont, Ilan Szwarc, Hélène Perrochia, Marie Christine Machet, Anthony Chauvin, Nicolas Mavroudakis, Guillaume Taieb, Luca Lanfranco, Claire Rigothier, Boucraut José, Catalano Concetta, Clair Geneste, Vincent Pernin, Christian Larroque, Jérôme Devaux, Anaïs Beyze Kidney Int
  Primary membranous nephropathy (MN) is an autoimmune glomerular disease in which autoantibodies are directed against podocyte proteins. In about 80% of cases the main targeted antigen is the phospholipase A2 receptor 1 (PLA2R1). Anti-PLA2R1 antibodies are mainly immunoglobulin G type 4 (IgG4). (...) (Kidney International 100, 6 (2021))

22 September

Kidney Int http://www.kidney-international.org/

• 00:00
  Effect of disease progression on the podocyte cell cycle in Alport Syndrome - Camille Nicolas Frank, Xiaogang Hou, Astgik Petrosyan, Valentina Villani, Rui Zhao, Joshua R. Hansen, Geremy Clair, Fadi Salem, Roger E. De Filippo, Paolo Cravedi, Kevin V. Lemley, Laura Perin Kidney Int
  Progression of glomerulosclerosis is associated with loss of podocytes with subsequent glomerular tuft instability. It is thought that a diminished number of podocytes may be able to preserve tuft stability through cell hypertrophy associated with cell cycle reentry. At the same time, reentry (...) (Kidney International 101, 1 (2022))

21 September

Kidney Int http://www.kidney-international.org/

• 00:00
  A secondary analysis of the Belimumab International Study in Lupus Nephritis trial examined effects of belimumab on kidney outcomes and preservation of kidney function in patients with lupus nephritis - Brad H. Rovin, Richard Furie, Y.K. Onno Teng, Gabriel Contreras, Ana Malvar, Xueqing Yu, Beulah Ji, Yulia Green, Tania Gonzalez-Rivera, Damon Bass, Jennifer Gilbride, Chun-Hang Tang, David A. Roth Kidney Int
  We performed a post hoc analysis of the Belimumab International Study in Lupus Nephritis (BLISS-LN), a Phase 3, multinational, double-blind, 104-week trial, in which 448 patients with lupus nephritis were randomized to receive intravenous belimumab 10 mg/kg or placebo with standard therapy (...) (Kidney International 101, 2 (2022))
• 00:00
  A pre-specified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial on the incidence of abrupt declines in kidney function - Hiddo J.L. Heerspink, David Cherney, Douwe Postmus, Bergur V. Stefánsson, Glenn M. Chertow, Jamie P. Dwyer, Tom Greene, Mikhail Kosiborod, Anna Maria Langkilde, John J.V. McMurray, Ricardo Correa-Rotter, Peter Rossing, C. David Sjöström, Robert D. Toto, David C. Wheeler, DAPA-CKD Trial Committees and Investigators Kidney Int
  This pre-specified analysis of DAPA-CKD assessed the impact of sodium-glucose cotransporter 2 inhibition on abrupt declines in kidney function in high-risk patients based on having chronic kidney disease (CKD) and substantial albuminuria. DAPA-CKD was a randomized, double-blind, (...) (Kidney International 101, 1 (2022))
• 00:00
  New-onset systemic lupus erythematosus beginning as class V lupus nephritis after COVID-19 vaccination - María Fernanda Zavala-Miranda, Samantha G. González-Ibarra, Abril A. Pérez-Arias, Norma O. Uribe-Uribe, Juan M. Mejia-Vilet Kidney Int
  We read the report by Tuschen et al. of a 42-year-old woman with a previous diagnosis of systemic lupus erythematosus (SLE) and class V lupus nephritis (LN) that developed a flare 1 week after vaccination with the mRNA coronavirus disease 2019 (COVID-19) vaccine BNT162b2 (Pfizer–BioNTech).1 (...) (Kidney International 100, 6 (2021))
• 00:00
  Combination treatment with rituximab, low-dose cyclophosphamide and plasma exchange for severe antineutrophil cytoplasmic antibody-associated vasculitis - Kavita Gulati, Helena Edwards, Maria Prendecki, Thomas D. Cairns, Marie Condon, Jack Galliford, Megan Griffith, Jeremy B. Levy, Frederick W.K. Tam, Anisha Tanna, Charles D. Pusey, Stephen P. McAdoo Kidney Int
  Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis can present with life-threatening lung-kidney syndromes. However, many controlled treatment trials excluded patients with diffuse alveolar hemorrhage or severely impaired glomerular filtration rates, and so the optimum treatment (...) (Kidney International 100, 6 (2021))

20 September

Kidney Int http://www.kidney-international.org/

• 00:00
  A mutation in the SAA1 promoter causes hereditary amyloid A amyloidosis - Jakub Sikora, Tereza Kmochová, Dita Mušálková, Michal Pohludka, Petr P?ikryl, Hana Hartmannová, Kate?ina Hoda?ová, Helena Trešlová, Lenka Nosková, Lenka Mrázová, Viktor Stránecký, Mariia Lunová, Milan Jirsa, Eva Honsová, Surendra Dasari, Ellen D. McPhail, Nelson Leung, Martina Živná, Anthony J. Bleyer, Ivan Rychlík, Romana Ryšavá, Stanislav Kmoch Kidney Int
  Amyloid A amyloidosis is a serious clinical condition resulting from the systemic deposition of amyloid A originating from serum amyloid A proteins with the kidneys being the most commonly and earliest affected organ. Previously described amyloid A amyloidosis is linked to increased production (...) (Kidney International 101, 2 (2022))
• 00:00
  The spatially resolved transcriptional profile of acute T cell–mediated rejection in a kidney allograft - Fadi Salem, Laura Perin, Sargis Sedrakyan, Andrea Angeletti, Gian Marco Ghiggeri, Maria Cristina Coccia, Marty Ross, Miguel Fribourg, Paolo Cravedi Kidney Int
  Analysis of the transcriptional profile of graft biopsies represents a promising strategy to study T cell–mediated-rejection (TCMR), also known as acute cellular rejection. However, bulk RNA sequencing of graft biopsies may not capture the focal nature of acute rejection. Herein, we used the (...) (Kidney International 101, 1 (2022))

18 September

Kidney Int http://www.kidney-international.org/

• 00:00
  The SARS-CoV-2–neutralizing capacity of kidney transplant recipients 4 weeks after receiving a second dose of the BNT162b2 vaccine - Rune M. Pedersen, Line L. Bang, Ditte S. Tornby, Helene Kierkegaard, Anna C. Nilsson, Isik S. Johansen, Claus Bistrup, Thøger G. Jensen, Ulrik S. Justesen, Thomas E. Andersen Kidney Int
  Coronavirus disease 2019 (COVID-19)–vaccinated kidney transplant recipients (KTRs) display a lower-than-normal antibody (Ab) response toward severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), indicating a reduced humoral immune response against the virus.1 A remaining question is to (...) (Kidney International 100, 5 (2021))

15 September

Kidney Int http://www.kidney-international.org/

• 00:00
  Proteinuric chronic kidney disease is associated with altered red blood cell lifespan, deformability and metabolism - Rosi Bissinger, Travis Nemkov, Angelo D'Alessandro, Marijke Grau, Thomas Dietz, Bernhard N. Bohnert, Daniel Essigke, Matthias Wörn, Lina Schaefer, Mengyun Xiao, Jonathan M. Beirne, M. Zaher Kalo, Anja Schork, Tamam Bakchoul, Kingsley Omage, Lingsi Kong, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Birgit Fehrenbacher, Martin Schaller, Achal Dhariwal, Andreas L. Birkenfeld, Florian Grahammer, Syed M. Qadri, Ferruh Artunc Kidney Int
  Anemia is a common complication of chronic kidney disease, affecting the quality of life of patients. Among various factors, such as iron and erythropoietin deficiency, reduced red blood cell (RBC) lifespan has been implicated in the pathogenesis of anemia. However, mechanistic data on in vivo (...) (Kidney International 100, 6 (2021))

14 September

Kidney Int http://www.kidney-international.org/

• 00:00
  The semaphorin 4A–neuropilin 1 axis alleviates kidney ischemia reperfusion injury by promoting the stability and function of regulatory T cells - Junnan Xu, Xiubin Li, Qing Yuan, Chenfeng Wang, Liang Xu, Xing Wei, Haitao Liu, Bo Yu, Zhekun An, Yuanyu Zhao, Xiang Li, Xu Zhang, Xin Ma, Ming Cai Kidney Int
  Previous studies have suggested the role of CD4+Foxp3+ regulatory T cells (Tregs) in protection against kidney ischemia reperfusion injury via their immunosuppressive properties. Unfortunately, the associated mechanisms of Tregs in kidney ischemia reperfusion injury have not been fully (...) (Kidney International 100, 6 (2021))
• 00:00
  Kidney toxicity of the BRAF-kinase inhibitor vemurafenib is driven by off-target ferrochelatase inhibition - Yuntao Bai, Ji Young Kim, Bijay Bisunke, Laura A. Jayne, Josie A. Silvaroli, Michael S. Balzer, Megha Gandhi, Kevin M. Huang, Veronika Sander, Jason Prosek, Rachel E. Cianciolo, Sharyn D. Baker, Alex Sparreboom, Kenar D. Jhaveri, Katalin Susztak, Amandeep Bajwa, Navjot Singh Pabla Kidney Int
  A multitude of disease and therapy related factors drive the frequent development of kidney disorders in cancer patients. Along with chemotherapy, the newer targeted therapeutics can also cause kidney dysfunction through on and off-target mechanisms. Interestingly, among the small molecule (...) (Kidney International 100, 6 (2021))
• 00:00
  COVID-19 vaccination followed by activation of glomerular diseases: does association equal causation? - Nicholas L. Li, P. Toby Coates, Brad H. Rovin Kidney Int
  To date, >4 billion doses of the various severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have been administered worldwide in response to the coronavirus disease 2019 (COVID-19) pandemic. Even as widespread vaccination campaigns have contributed to declining case rates, (...) (Kidney International 100, 5 (2021))

10 September

Kidney Int http://www.kidney-international.org/

• 00:00
  In memoriam: Charles. R. Kleeman - Gabriel Danovitch, Leon Fine Kidney Int
  Charles (Chuck) Kleeman, MD, a giant of 20th century nephrology, died peacefully on Sunday, August 15, 2021. He was 97 years old. (Kidney International 100, 5 (2021))

9 September

Kidney Int http://www.kidney-international.org/

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  A third vaccine dose substantially improves humoral and cellular SARS-CoV-2 immunity in renal transplant recipients with primary humoral nonresponse - Timm H. Westhoff, Felix S. Seibert, Moritz Anft, Arturo Blazquez-Navarro, Sarah Skrzypczyk, Panagiota Zgoura, Toni L. Meister, Stephanie Pfaender, Julian Stumpf, Christian Hugo, Richard Viebahn, Toralf Roch, Ulrik Stervbo, Nina Babel Kidney Int
  Renal transplant recipients (RTRs) are at a high risk for fatal coronavirus disease 2019 (COVID-19).1 Vaccinations are indispensable to protect this vulnerable population. Unfortunately, >50% of solid organ recipients do not mount antibody responses after 2 doses of severe acute respiratory (...) (Kidney International 100, 5 (2021))

6 September

Kidney Int http://www.kidney-international.org/

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  Impact of rituximab on humoral response to COVID-19 booster vaccine and antibody kinetics in patients with anti–neutrophil cytoplasmic antibody vasculitis - Sam Kant, Duvuru Geetha Kidney Int
  The advent of vaccines has resulted in mitigation of severe disease as a consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There is notable absence of humoral response after 2 doses of mRNA vaccines in rheumatic and musculoskeletal diseases.1 There has been evidence (...) (Kidney International 100, 5 (2021))

2 September

Kidney Int http://www.kidney-international.org/

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  Risk factors associated with poor response to COVID-19 vaccination in kidney transplant recipients - Yorg Azzi, Harith Raees, Tao Wang, Levi Cleare, Luz Liriano-Ward, Pablo Loarte-Campos, Cindy Pynadath, Maria Ajaimy, Omar Alani, Yi Bao, Liise-anne Pirofski, Enver Akalin Kidney Int
  The case fatality ratio of coronavirus disease 2019 (COVID-19) in kidney transplant recipients is between 10% and 30%,1,2 underscoring the importance of vaccination to prevent COVID-19. However, kidney transplant recipients have a reduced response to COVID-19 vaccines (18%–54%).3,4 We determined (...) (Kidney International 100, 5 (2021))

1 September

Kidney Int http://www.kidney-international.org/

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  Safety, pharmacodynamics, and exposure-response modeling results from a first-in-human phase 1 study of nedosiran (PHYOX1) in primary hyperoxaluria - Bernd Hoppe, Annelize Koch, Pierre Cochat, Sander F. Garrelfs, Michelle A. Baum, Jaap W. Groothoff, Graham Lipkin, Martin Coenen, Gesa Schalk, Aniruddha Amrite, David McDougall, Kelly Barrios, Craig B. Langman Kidney Int
  Primary hyperoxaluria (PH) is a family of ultra-rare autosomal recessive inherited disorders of hepatic glyoxylate metabolism characterized by oxalate overproduction. Nedosiran is an RNA interference agent that inhibits hepatic lactate dehydrogenase, the enzyme responsible for the common, final (...) (Kidney International 101, 3 (2022))

30 August

Kidney Int http://www.kidney-international.org/

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  Better late than never: eventual seroconversion against SARS-CoV-2 in a kidney transplant recipient after repeated immune challenge and monoclonal antibody therapy - Julien De Greef, Arnaud Devresse, Imane Saad Albichr, Anais Scohy, Nada Kanaan, Hélène Georgery, Leila Belkhir, Benoit Kabamba, Jean Cyr Yombi, Eric Goffin Kidney Int
  Kidney transplant recipients are disproportionately affected by coronavirus disease 2019 (COVID-19). In addition to limited therapeutic options, concerns have arisen regarding poor vaccine efficacy in this population.1 (Kidney International 100, 5 (2021))
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  A third injection of the BNT162b2 mRNA COVID-19 vaccine in kidney transplant recipients improves the humoral immune response - Christophe Masset, Clarisse Kerleau, Claire Garandeau, Simon Ville, Diego Cantarovich, Maryvonne Hourmant, Delphine Kervella, Aurélie Houzet, Cécile Guillot-Gueguen, Irène Guihard, Magali Giral, Jacques Dantal, Gilles Blancho Kidney Int
  Several reports have highlighted the poor humoral immune response of kidney transplant recipients following coronavirus disease 2019 (COVID-19) mRNA vaccination compared with immunocompetent patients.1–3 Therefore, the French National Authority for Health has recommended the use of a third (...) (Kidney International 100, 5 (2021))
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  Angiotensin-converting enzyme 2 decreased expression during kidney inflammatory diseases: implications to predisposing to COVID-19 kidney complications - Gabriela E. Garcia, Luan D. Truong, Richard J. Johnson Kidney Int
  Although angiotensin-converting enzyme 2 (ACE2) is the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into target cells, it has a major anti-inflammatory role by hydrolyzing angiotensin II, a proinflammatory mediator, to angiotensin 1-7, an anti-inflammatory (...) (Kidney International 100, 5 (2021))
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  The state of the global nephrology workforce: a joint ASN–ERA-EDTA–ISN investigation - Stephen M. Sozio, Kurtis A. Pivert, Fergus J. Caskey, Adeera Levin Kidney Int
  Chronic kidney disease (CKD) is a global health crisis, affecting 11% to 13% of the world’s population.1,2 Although gaps in the workforce and available training pathways have been explored,3,4 it remains unclear if nephrologist availability, measured as ratios of nephrologists to both the (...) (Kidney International 100, 5 (2021))

19 August

Kidney Int http://www.kidney-international.org/

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  Anti–SARS-CoV-2 spike protein S1 receptor-binding domain antibody after vaccination with inactivated whole-virus SARS-CoV-2 in end-stage kidney disease patients: an initial report - Sarinya Boongird, Piyatida Chuengsaman, Salinnart Phanprasert, Rungthiwa Kitpermkiat, Montira Assanatham, Arkom Nongnuch, Sasisopin Kiertiburanakul, Kumthorn Malathum, Angsana Phuphuakrat, Chavachol Setthaudom, Jackrapong Bruminhent Kidney Int
  Patients with end-stage kidney disease (ESKD) are at greater risk for morbidity and mortality following coronavirus disease 2019 (COVID-19) than the general population.1 Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for this vulnerable population is the main (...) (Kidney International 100, 5 (2021))
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  Membranous nephropathy following anti–COVID-19 mRNA vaccination - Lorraine Gueguen, Charlotte Loheac, Nadia Saidani, Lydie Khatchatourian Kidney Int
  A 76-year-old man with a history of hypertension and UV-treated cutaneous mycosis fungoid was vaccinated in January 2021 for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with Bnt162b2 and developed an antibody response. He had not had prior coronavirus disease 2019 (COVID-19) (...) (Kidney International 100, 5 (2021))

18 August

Kidney Int http://www.kidney-international.org/

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  A multicenter feasibility randomized controlled trial to assess the impact of incremental versus conventional initiation of hemodialysis on residual kidney function - Enric Vilar, Raja M. Kaja Kamal, James Fotheringham, Amanda Busby, Jocelyn Berdeprado, Ewa Kislowska, David Wellsted, Bassam Alchi, James O. Burton, Andrew Davenport, Ken Farrington Kidney Int
  Twice-weekly hemodialysis, as part of incremental initiation, has reported benefits including preservation of residual kidney function (RKF). To explore this, we initiated a randomized controlled feasibility trial examining 55 incident hemodialysis patients with urea clearance of 3 ml/min/1.73 (...) (Kidney International 101, 3 (2022))
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  A randomized multicenter trial on a lung ultrasound–guided treatment strategy in patients on chronic hemodialysis with high cardiovascular risk - Carmine Zoccali, Claudia Torino, Francesca Mallamaci, Pantelis Sarafidis, Aikaterini Papagianni, Robert Ekart, Radovan Hojs, Marian Klinger, Krzysztof Letachowicz, Danilo Fliser, Sarah Seiler-Mußler, Fabio Lizzi, Andrzej Wiecek, Agata Miskiewicz, Kostas Siamopoulos, Olga Balafa, Itzchak Slotki, Linda Shavit, Aristeidis Stavroulopoulos, Adrian Covic, Dimitrie Siriopol, Ziad A. Massy, Alexandre Seidowsky, Yuri Battaglia, Alberto Martinez-Castelao, Carolina Polo-Torcal, Marie-Jeanne Coudert-Krier, Patrick Rossignol, Enrico Fiaccadori, Giuseppe Regolisti, Thierry Hannedouche, Thomas Bachelet, (...) Kidney Int
  Lung congestion is a risk factor for all-cause and cardiovascular mortality in patients on chronic hemodialysis, and its estimation by ultrasound may be useful to guide ultrafiltration and drug therapy in this population. In an international, multi-center randomized controlled trial (...) (Kidney International 100, 6 (2021))

2 August

Kidney Int http://www.kidney-international.org/

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  A multi-center retrospective cohort study defines the spectrum of kidney pathology in Coronavirus 2019 Disease (COVID-19) - Rebecca M. May, Clarissa Cassol, Andrew Hannoudi, Christopher P. Larsen, Edgar V. Lerma, Randy S. Haun, Juarez R. Braga, Samar I. Hassen, Jon Wilson, Christine VanBeek, Mahesha Vankalakunti, Lilli Barnum, Patrick D. Walker, T. David Bourne, Nidia C. Messias, Josephine M. Ambruzs, Christie L. Boils, Shree S. Sharma, L. Nicholas Cossey, Pravir V. Baxi, Matthew Palmer, Jonathan E. Zuckerman, Vighnesh Walavalkar, Anatoly Urisman, Alexander J. Gallan, Laith F. Al-Rabadi, Roger Rodby, Valerie Luyckx, Gustavo Espino, Srivilliputtur Santhana-Krishnan, Brent Alper, Son G. Lam, Ghadeer N. Hannoudi, (...) Kidney Int
  Kidney failure is common in patients with Coronavirus Disease-19 (COVID-19), resulting in increased morbidity and mortality. In an international collaboration, 284 kidney biopsies were evaluated to improve understanding of kidney disease in COVID-19. Diagnoses were compared to five years of (...) (Kidney International 100, 6 (2021))
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  Iron status, fibroblast growth factor 23 and cardiovascular and kidney outcomes in chronic kidney disease - Rupal C. Mehta, Monique E. Cho, Xuan Cai, Jungwha Lee, Jing Chen, Jiang He, John Flack, Tariq Shafi, Santosh L. Saraf, Valentin David, Harold I. Feldman, Tamara Isakova, Myles Wolf, CRIC Study Investigators Kidney Int
  Disordered iron and mineral homeostasis are interrelated complications of chronic kidney disease that may influence cardiovascular and kidney outcomes. In a prospective analysis of 3747 participants in the Chronic Renal Insufficiency Cohort Study, we investigated risks of mortality, heart (...) (Kidney International 100, 6 (2021))
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  A Mendelian randomization study found causal linkage between telomere attrition and chronic kidney disease - Sehoon Park, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim Kidney Int
  Chronic kidney disease (CKD) is highly prevalent in the elderly population. However, it is rarely investigated whether kidney function is causally linked to biological aging itself. In this Mendelian randomization study, genetic instruments for telomere attrition were applied to a CKDGen genome (...) (Kidney International 100, 5 (2021))

29 July

Kidney Int http://www.kidney-international.org/

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  The circadian clock regulates rhythmic erythropoietin expression in the murine kidney - Lina K. Sciesielski, Matthias Felten, Laura Michalick, Karin M. Kirschner, Georgia Lattanzi, Charlotte L.J. Jacobi, Thomas Wallach, Veronika Lang, Dominic Landgraf, Achim Kramer, Christof Dame Kidney Int
  Generation of circadian rhythms is cell-autonomous and relies on a transcription/translation feedback loop controlled by a family of circadian clock transcription factor activators including CLOCK, BMAL1 and repressors such as CRY1 and CRY2. The aim of the present study was to examine both the (...) (Kidney International 100, 5 (2021))
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  A mathematical estimation of the physical forces driving podocyte detachment - Linus Butt, David Unnersjö-Jess, Martin Höhne, Bernhard Schermer, Aurelie Edwards, Thomas Benzing Kidney Int
  Loss of podocytes, possibly through the detachment of viable cells, is a hallmark of progressive glomerular disease. Podocytes are exposed to considerable physical forces due to pressure and flow resulting in circumferential wall stress and tangential shear stress exerted on the podocyte cell (...) (Kidney International 100, 5 (2021))

23 July

Kidney Int http://www.kidney-international.org/

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  Vitamin K and cardiovascular complications in chronic kidney disease patients - Nadine Kaesler, Leon J. Schurgers, Jürgen Floege Kidney Int
  Vitamin K, well known for its role in coagulation, encompasses 2 major subgroups: vitamin K1 is exclusively synthesized by plants, whereas vitamin K2 mostly originates from bacterial synthesis. Vitamin K serves as a cofactor for the enzyme ?-glutamyl carboxylase, which carboxylates and thereby (...) (Kidney International 100, 5 (2021))

21 July

Kidney Int http://www.kidney-international.org/

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  Rescuing kidney patients from early demise: role of anti-cytokine therapies - T. Alp Ikizler, Jonathan Himmelfarb Kidney Int
  Biomarkers of the inflammatory state are elevated in individuals with chronic kidney disease (CKD) and are also robust predictors of cardiovascular disease (CVD) and mortality in this population. In addition to its predictive ability, inflammation has been implicated in the pathogenesis of (...) (Kidney International 100, 6 (2021))

20 July

Kidney Int http://www.kidney-international.org/

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  Skimming the fat in diabetic kidney disease: KIM-1 and tubular fatty acid uptake - Huihui Huang, Samir M. Parikh Kidney Int
  Diabetic kidney disease (DKD) accounts for >40% of incident ESKD cases. The clinical hallmarks of DKD include reduced glomerular filtration rate (GFR) and increased urinary albumin excretion. Although DKD is traditionally considered a glomerular disease, tubulointerstitial injury is (...) (Kidney International 100, 5 (2021))

17 July

Kidney Int http://www.kidney-international.org/

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  How cyclosporine reduces mycophenolic acid exposure by 40% while other calcineurin inhibitors do not - Teun van Gelder Kidney Int
  The most frequently used immunosuppressive treatment in kidney transplant recipients is the combination therapy of a calcineurin inhibitor (CNI) and mycophenolate mofetil, with or without corticosteroids. Cyclosporine and tacrolimus are the 2 CNIs registered for this indication. Also, in the (...) (Kidney International 100, 6 (2021))

16 July

Kidney Int http://www.kidney-international.org/

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  A team-based approach for testing biomarkers of kidney disease progression - Javier A. Neyra Kidney Int
  Acute kidney injury (AKI) is an important public health concern given its high incidence, paucity of effective therapies, and strong association with mortality. Survivors of hospitalized AKI are at increased risk of cardiovascular disease, de novo chronic kidney disease (CKD), and progression (...) (Kidney International 100, 5 (2021))

8 July

Kidney Int http://www.kidney-international.org/

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  The ketone body ?-hydroxybutyrate mitigates the senescence response of glomerular podocytes to diabetic insults - Yudong Fang, Bohan Chen, Athena Y. Gong, Deepak K. Malhotra, Rajesh Gupta, Lance D. Dworkin, Rujun Gong Kidney Int
  Diabetic kidney disease (DKD) is one of the most common complications of diabetes and is clinically featured by progressive albuminuria, consequent to glomerular destruction that involves podocyte senescence. Burgeoning evidence suggests that ketosis, in particular ?-hydroxybutyrate, exerts a (...) (Kidney International 100, 5 (2021))

7 July

Kidney Int http://www.kidney-international.org/

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  Significance of HLA-DQ in kidney transplantation: time to reevaluate human leukocyte antigen–matching priorities to improve transplant outcomes? An expert review and recommendations - Anat R. Tambur, Vasilis Kosmoliaptsis, Frans H.J. Claas, Roslyn B. Mannon, Peter Nickerson, Maarten Naesens Kidney Int
  The weight of human leukocyte antigen (HLA) matching in kidney allocation algorithms, especially in the United States, has been devalued in a stepwise manner, supported by the introduction of modern immunosuppression. The intent was further to reduce the observed ethnic/racial disparity, as (...) (Kidney International 100, 5 (2021))