27 March

Kidney Int http://www.kidney-international.org/

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  International Society of Nephrology first consensus guidance for preclinical animal studies in translational nephrology - Masaomi Nangaku, A. Richard Kitching, Peter Boor, Alessia Fornoni, Jürgen Floege, P. Toby Coates, Jonathan Himmelfarb, Rachel Lennon, Hans-Joachim Anders, Benjamin D. Humphreys, Fergus J. Caskey, Agnes B. Fogo, the TRANSFORM group Kidney Int
  Preclinical tests in animal models are key steps in early drug development. Consequently, the International Society of Nephrology held a consensus meeting that connected experts in the global kidney community in order to provide guidance on optimal management of translational animal studies for (...) (Kidney International (2023))
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  Devices for long-term hemodialysis in small children – a plea for action - B Ranchin, CP Schmitt, B Warady, JC Craig, C Licht, H Hataya, E Vidal, J Vande Walle, R Shroff Kidney Int
  International registry data show that 11 to 37% of children initiating maintenance hemodialysis (HD) weigh less than 20kg, with 4 to 14% weighing between 10 and 15 kg and 2 to 9% less than 10kg1-3. The smaller blood volume in young children necessitates both low-volume tubing systems and (...) (Kidney International (2023))
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  Prospective, Randomized, Multicenter, Clinical Study Comparing a Self-Expanding Covered Stent to Percutaneous Transluminal Angioplasty for Treatment of Upper Extremity Hemodialysis Arteriovenous Fistula Stenosis - Bart Dolmatch, Timoteo Cabrera, Pablo Pergola, Saravanan Balamuthusamy, Angelo Makris, Randy Cooper, Erin Moore, Jonah Licht, Ewan Macaulay, Geert Maleux, Thomas Pfammatter, Richard Settlage, Ecaterina Cristea, Alexandra Lansky, for the AVeNEW Trial Investigators Kidney Int
  Use of a covered stent after percutaneous transluminal angioplasty (PTA) was compared to PTA alone for treatment of upper extremity hemodialysis patients with arteriovenous fistula (AVF) stenoses. Patients with AVF stenosis of 50% or more and evidence of AVF dysfunction underwent treatment with (...) (Kidney International (2023))
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  Deep learning-based segmentation and quantification of podocyte foot process morphology suggests differential patterns of foot process effacement across kidney pathologies - David Unnersjö-Jess, Linus Butt, Martin Höhne, German Sergei, Arash Fatehi, Anna Witasp, Annika Wernerson, Jaakko Patrakka, Peter F. Hoyer, Hans Blom, Bernhard Schermer, Katarzyna Bozek, Thomas Benzing Kidney Int
  We here describe that using deep-learning based segmentation and new imaging protocols, foot process morphometry can be automatically extracted from images of human biopsies. Our results indicate that individual patterns of foot process effacement differ between patients and correlate with (...) (Kidney International (2023))
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  A single approach to targeting transferrin receptor 2 corrects iron and erythropoietic defects in murine models of anemia of inflammation and chronic kidney disease. - Violante Olivari, Simona Maria Di Modica, Maria Rosa Lidonnici, Mariam Aghajan, Celia Cordero-Sanchez, Emanuele Tanzi, Mariateresa Pettinato, Alessia Pagani, Francesca Tiboni, Laura Silvestri, Shuling Guo, Giuliana Ferrari, Antonella Nai Kidney Int
  The management of anemia of inflammation and anemia of CKD is still suboptimal. EPO-mimetics may be associated to cardiovascular side effects because of extra-erythroid EPO functions. The recently developed Prolyl-hydroxylase inhibitors (PHIs), which increase the levels of the Hypoxia-inducible (...) (Kidney International (2023))
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  Subclinical rejection-free diagnostic after kidney transplantation using blood gene expression - Richard Danger, Ludmilla Le Berre, Marion Cadoux, Clarisse Kerleau, Emmanuelle Papuchon, Pierrick Guérif, Emmanuel Morelon, Olivier Thaunat, Christophe Legendre, Dany Anglicheau, Carmen Lefaucheur, Lionel Couzi, Arnaud Del Bello, Nassim Kamar, Moglie Le Quintrec, Valentin Goutaudier, Karine Renaudin, Magali Giral, Sophie Brouard, RHU KTD-Innov and DIVAT consortia Kidney Int
  We previously established a six-gene-based blood score associated with operational tolerance in kidney transplantation which was decreased in patients developing anti-HLA donor-specific antibodies (DSA). Herein, we aimed to confirm that this score is associated with immunological events and (...) (Kidney International (2023))

22 March

Kidney Int http://www.kidney-international.org/

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  DNA binding protein YB-1 is a part of the neutrophil extracellular trap mediation of kidney damage and cross-organ effects. - Jialin Wang, Xiyang Liu, Yulu Gu, Yingying Gao, Vera Jankowski, Nina Was, Anna Leitz, Lucy K. Reiss, Yiqin Shi, Jieru Cai, Yi Fang, Nana Song, Shuan Zhao, Jürgen Floege, Tammo Ostendorf, Xiaoqiang Ding, Ute Raffetseder Kidney Int
  Open-heart surgery is associated with high morbidity, with acute kidney injury (AKI) being one of the most commonly observed postoperative complications. Following open-heart surgery, in an observational study we found significantly higher numbers of blood neutrophils in a group of 13 patients (...) (Kidney International (2023))
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  Novel MUC1 variant identified by massively parallel sequencing explains interstitial kidney disease in a large Dutch family - Amber de Haan, Albertien M. van Eerde, Mark Eijgelsheim, Patrick Rump, Bert van der Zwaag, Eric Hennekam, Martina Živná, Stanislav Kmoch, Anthony J. Bleyer, Kendrah Kidd, Liffert Vogt, Nine V.A.M. Knoers, Martin H. de Borst Kidney Int
  Chronic kidney disease (CKD) can be caused by various systemic and kidney disorders with overlapping or nonspecific clinical presentations. Despite a thorough diagnostic workup, the primary cause of CKD remains uncertain in 20% to 35% of affected individuals.1,2 Recent studies have demonstrated (...) (Kidney International (2023))

20 March

Kidney Int http://www.kidney-international.org/

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  From bench to bedside: Lessons learned from translational podocyte research - Olivia Lenoir, Tobias B. Huber, Pierre-Louis Tharaux Kidney Int
  Polat et al. report that mice with a podocyte-specific expression of a constitutively-active Rac1 form displayed similar injury and albuminuria, irrespectively of Transient Receptor Potential Canonical 5 (TRPC5) activity. This article confirms the pathogenic role of deregulated Rac1 and (...) (Kidney International (2023))
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  Table of Contents Kidney Int
  (Kidney International 103, 4 (2023))
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  Subscription Information Kidney Int
  (Kidney International 103, 4 (2023))
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  Editorial Board Kidney Int
  (Kidney International 103, 4 (2023))
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  Acknowledgment of reviewers Kidney Int
  The Editors are grateful to the following Reviewers who evaluated manuscripts for Kidney International during 2022. (Kidney International 103, 4 (2023))
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  journal club Kidney Int
  Takahashi et al., on behalf of the American Heart Association Council on Cardiovascular Radiology and Intervention; Council on Hypertension; Council on the Kidney in Cardiovascular Disease; and Stroke Council. (Circulation. 2022;146:e558–e568.) (Kidney International 103, 4 (2023))
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  in this issue Kidney Int
  The Jaffe reaction is the most commonly used test to measure creatinine levels. High levels of glucose can interfere with Jaffe, causing it to overestimate creatinine. Because the use of sodium-glucose cotransporter 2 (SGLT2) inhibitors (SGLT2i) is increasing dramatically in patients with (...) (Kidney International 103, 4 (2023))
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  Glucocorticoids for IgA nephropathy—pro - Yue-Miao Zhang, Ji-Cheng Lv, Muh Geot Wong, Hong Zhang, Vlado Perkovic Kidney Int
  Since IgA nephropathy (IgAN) was first described in 1968 by Jean Berger, supportive lifestyle measures and blood pressure lowering agents, especially renin-angiotensin system inhibitors (RASi), have become first-line treatment. Despite this, a substantial risk of progression remains even when (...) (Kidney International 103, 4 (2023))
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  First do no harm: systemic glucocorticoids should not be used for the treatment of progressive IgA nephropathy - Chee Kay Cheung, Jonathan Barratt Kidney Int
  Over recent years, significant progress has been made in the understanding of the pathogenesis of IgA nephropathy (IgAN). A multihit model is widely accepted; in patients with IgAN, there is an increase in circulating poorly galactosylated IgA1, likely to be of mucosal origin, that drives (...) (Kidney International 103, 4 (2023))
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  IgA nephropathy and glucocorticoids—a limbo dance? - Brad H. Rovin Kidney Int
  In this issue of Kidney International, arguments are presented for and against the use of systemic glucocorticoids (GCs) in the treatment of IgA nephropathy (IgAN) that is likely to progress. The use of immunomodulation in IgAN makes sense. The immune system, especially the mucosal immune (...) (Kidney International 103, 4 (2023))
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  Advances in biodesign: artificial water channels outperforming aquaporins - Ines P.D. Costa, Iain A. Drummond, Olivier Devuyst Kidney Int
  Water channels mediating fast water transport across biological membranes are essential for water balance in all living organisms. The archetypal water channel, aquaporin-1 (AQP1), was cloned from human erythrocytes by Denker et al. in the late 1980s,1 and its function was demonstrated by a (...) (Kidney International 103, 4 (2023))
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  Corrigendum to “Myeloid cyclooxygenase-2/prostaglandin E2/E-type prostanoid receptor 4 promotes transcription factor MafB-dependent inflammatory resolution in acute kidney injury.” Kidney Int. 2022;101:79–91 - Yu Pan, Shirong Cao, Andrew S. Terker, Jiaqi Tang, Kensuke Sasaki, Yinqiu Wang, Aolei Niu, Wentian Luo, Dhouha Daassi, Xiaofeng Fan, Suwan Wang, Matthew H. Wilson, Ming-Zhi Zhang, Raymond C. Harris Kidney Int
  The authors of the above-stated article regret the misspelled name of the author Dhouha Daassi. (Kidney International 103, 4 (2023))
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  Novel mechanism of increased preeclampsia risk after kidney donation - Elizabeth Ann L. Enninga, Vesna D. Garovic Kidney Int
  Preeclampsia is a hypertensive disorder of pregnancy diagnosed after 20 weeks of gestation in the presence of maternal elevated blood pressures accompanied by proteinuria or organ dysfunction, including kidney insufficiency. Although low-dose aspirin is recommended for preeclampsia prevention (...) (Kidney International 103, 4 (2023))
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  Solving the insoluble: calciprotein particles mediate bulk mineral transport - Willi Jahnen-Dechent, Andreas Pasch Kidney Int
  Protein mineral complexes, or calciprotein particles, are formed by calcium, phosphate, and the plasma protein fetuin-A. Crystalline calciprotein particles cause soft tissue calcification, oxidative stress, and inflammation, all well-known complications in chronic kidney disease. The T50 (...) (Kidney International 103, 4 (2023))
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  Kidney-specific metabolomic profiling in machine perfusate - Eugene P. Rhee Kidney Int
  Given their accessibility and relevance to established clinical workflows, blood and urine have been the major focus of investigation in metabolomics studies of human kidney disease. In this issue, Liu et al. describe the application of metabolomics to perfusate from donor kidneys subjected to (...) (Kidney International 103, 4 (2023))
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  A transitional B-cell cytokine biomarker for risk stratifying renal transplant patients with borderline rejection - Sumoyee Basu, Anthony Dorling, Anita S. Chong Kidney Int
  Borderline allograft rejection can promote acute rejection and graft loss in some, but not all, patients. In this issue, Cherukuri et al. use a novel test based on peripheral blood transitional T1 B cells producing interleukin-10 and tumor necrosis factor-?, which identifies patients at high (...) (Kidney International 103, 4 (2023))
• 11:46
  Fosl1: friend or foe? - Shruti Bhargava, Joachim Jankowski Kidney Int
  Fos-like antigen 1 (Fosl1) is a protein that belongs to the Fos family of transcription factors. Fosl1 has an impact on (i) carcinogenesis, (ii) acute kidney injury, and (iii) fibroblast growth factor expression. Recently, the nephroprotective effect of Fosl1 by the preservation of Klotho (...) (Kidney International 103, 4 (2023))
• 11:46
  Pulmonary-renal syndrome in IgA vasculitis - Sascha T. Bender, Peter R. Mertens, Christian Gross Kidney Int
  A 65-year old man was admitted with acute kidney failure, respiratory difficulty, and hemoptysis. He had a medical history of chronic kidney disease stage 3A. He noted a skin rash starting 4 days before admission, accompanied by arthralgia affecting both knees and ankles, abdominal pain, and (...) (Kidney International 103, 4 (2023))
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  Spheroplasts in the urinary sediment - Giovanni Battista Fogazzi, Giuseppe Garigali Kidney Int
  A 33-year-old woman, who 4 months before had received a cadaveric kidney transplant for end-stage kidney disease caused by chronic pyelonephritis, was seen in clinic for routine follow-up. The patient was asymptomatic and was receiving treatment with anti-rejection medications and oral cefixime (...) (Kidney International 103, 4 (2023))
• 11:46
  The Case | Hematuria and hypercalcemia in a kidney transplant recipient - Athiphat Banjongjit, Thunyatorn Wuttiputhanun, Jakapat Vanichanan, Thornthun Ueaphongsukkit, Kroonpong Iampenkhae, Yingyos Avihingsanon, Natavudh Townamchai Kidney Int
  A 25-year-old woman presented with dysuria and intermittent gross hematuria for 2 weeks. She underwent a kidney transplantation 2 years earlier because of end-stage kidney disease of unknown cause. She received basiliximab as induction therapy, followed by maintenance immunosuppression with (...) (Kidney International 103, 4 (2023))

18 March

Kidney Int http://www.kidney-international.org/

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  Podocyte protease actuated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events. - Carl J May, Musleeha Chesor, Sarah E Hunter, Bryony Hayes, Rachel Barr, Tim Roberts, Fern A Barrington, Louise Farmer, Lan Ni, Maisie Jackson, Heidi Snethen, Nadia Tavakolidakhrabadi, Max Goldstone, Rodney Gilbert, Matt Beesley, Rachel Lennon, Rebecca Foster, Richard Coward, Gavin I Welsh, Moin A Saleem Kidney Int
  About 30% of patients who have a kidney transplant with underlying nephrotic syndrome (NS) experience rapid relapse of disease in their new graft. This is speculated to be due to a host-derived circulating factor acting on podocytes, the target cells in the kidney; leading to focal segmental (...) (Kidney International (2023))
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  PROTEINURIA AND HEMATURIA AFTER REMISSION INDUCTION ARE ASSOCIATED WITH OUTCOME IN ANCA-ASSOCIATED VASCULITIS - Nicolas Benichou, Pierre Charles, Benjamin Terrier, Rachel B Jones, Thomas Hiemstra, Luc Mouthon, Ingeborg Bajema, Annelies Berden, Eric Thervet, Loïc Guillevin, David Jayne, Alexandre Karras, French Vasculitis Study Group (FVSG) and European Vasculitis Society (EUVAS) investigators Kidney Int
  In anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), hematuria and proteinuria are biomarkers reflecting kidney involvement at diagnosis. Yet, the prognostic value of their persistence after immunosuppressive induction therapy, reflecting kidney damage or persistent (...) (Kidney International (2023))

14 March

Kidney Int http://www.kidney-international.org/

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  The CCR6/CCL20 axis expands ROR?t+ Tregs to protect from glomerulonephritis - Georg R. Herrnstadt, Christoph B. Niehus, Torben Ramcke, Julia Hagenstein, Laura-Isabell Ehnold, Anna Nosko, Matthias T. Warkotsch, Frederic C. Feindt, Simon Melderis, Hans-Joachim Paust, Varshi Sivayoganathan, Saskia-Larissa Jauch-Speer, Milagros N. Wong, Daniela Indenbirken, Christian F. Krebs, Tobias B. Huber, Ulf Panzer, Victor G. Puelles, Malte A. Kluger, Oliver M. Steinmetz Kidney Int
  Previous studies have identified a unique Treg population, which expresses the Th17 characteristic transcription factor ROR?t. These ROR?t+ Tregs possess enhanced immunosuppressive capacity, which endows them with great therapeutic potential. However, as a caveat, they are also capable of (...) (Kidney International (2023))

13 March

Kidney Int http://www.kidney-international.org/

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  Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury - Ji Young Kim, Josie A. Silvaroli, Gabriela Vasquez Martinez, Bijay Bisunke, Alanys V. Luna Ramirez, Laura A. Jayne, Mei Ji He Ho Feng, Bhavya Girotra, Shirely M. Acosta Martinez, Corynne R. Vermillion, Isaac Z. Karel, Nicholas Ferrell, Noah Weisleder, Sangwoon Chung, John W. Christman, Craig R. Brooks, Sethu M. Madhavan, Kari R. Hoyt, Rachel E. Cianciolo, Anjali A. Satoskar, Diana Zepeda-Orozco, Jennifer C. Sullivan, Alan J. Davidson, Amandeep Bajwa, Navjot Singh (...) Kidney Int
  Transcriptional profiling studies have identified several protective genes upregulated in tubular epithelial cells during acute kidney injury (AKI). Identifying upstream transcriptional regulators could lead to the development of therapeutic strategies augmenting the repair processes. SOX9 is a (...) (Kidney International (2023))

12 March

Kidney Int http://www.kidney-international.org/

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  Acute tubulointerstitial nephritis with or without uveitis: a novel form of post-acute COVID-19 syndrome in children - Marina Avramescu, Pierre Isnard, Sarah Temmam, Agnès Chevalier, Paul Bastard, Mikael Attia, Romain Berthaud, Marc Fila, Claire Dossier, Julien Hogan, Tim Ulinski, Damia Leguevaques, Férielle Louillet, Edouard Martinez Casado, Jean-Michel Halimi, Sylvie Cloarec, Ariane Zaloszyc, Camille Faudeux, Caroline Rousset-Rouvière, Stéphanie Clavé, Jérôme Harambat, Edouard Rollot, Thomas Simon, Megan Nallet-Amate, Bruno Ranchin, Justine Bacchetta, Florence Porcheret, Josselin Bernard, Amélie Ryckewaert, Anne Jamet, Jacques Fourgeaud, Nicolas Da Rocha, Philippe Pérot, Nicolas Kuperwasser, Naïm Bouazza, (...) Kidney Int
  Multiorgan sequelae of coronavirus disease 2019 (COVID-19) beyond the acute phase of infection are increasingly described as clinical experience expands. In children, acute COVID-19 appears to be generally asymptomatic or mild. Yet, the multisystem inflammatory syndrome in children (MIS-C) may (...) (Kidney International (2023))

8 March

Kidney Int http://www.kidney-international.org/

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  A multicenter retrospective study of calcineurin inhibitors in nephrotic syndrome secondary to podocyte gene variants - Georgia Malakasioti, Daniela Iancu, Anastasiia Milovanova, Alexey Tsygin, Tomoko Horinouchi, China Nagano, Kandai Nozu, Koichi Kamei, Shuichiro Fujinaga, Kazumoto Iijima, Rajiv Sinha, Biswanath Basu, William Morello, Giovanni Montini, Aoife Waters, Olivia Boyer, Zeynep Yürük Y?ld?r?m, Sibel Yel, ?smail Dursun, Hugh J. McCarthy, Marina Vivarelli, Larisa Prikhodina, Martine T.P. Besouw, Eugene Yu-hin Chan, Wenyan Huang, Markus J. Kemper, Sebastian Loos, Chanel Prestidge, William Wong, Galia Zlatanova, Rasmus Ehren, Lutz T. Weber, Hassib Chehade, Nakysa Hooman, Marcin Tkaczyk, Ma?gorzata (...) Kidney Int
  While 44-83% of children with steroid-resistant nephrotic syndrome (SRNS) without a proven genetic cause respond to treatment with a calcineurin inhibitor (CNI), current guidelines recommend against the use of immunosuppression in monogenic SRNS. This is despite existing evidence suggesting (...) (Kidney International (2023))

3 March

Kidney Int http://www.kidney-international.org/

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  Glycolate oxidase inhibition by lumasiran varies between patients with primary hyperoxaluria type 1 - Sander F. Garrelfs, Elisabeth L. Metry, Dewi van Harskamp, Frederic M. Vaz, Chris H.P. van den Akker, Henk Schierbeek, Jaap W. Groothoff, Michiel J.S. Oosterveld Kidney Int
  Primary hyperoxaluria type 1 (PH1) is a rare metabolic disease caused by a deficiency of the liver-specific enzyme alanine/glyoxylate aminotransferase, which results in an increased endogenous oxalate production (EOP),1 leading to kidney stones, nephrocalcinosis, and eventually kidney failure. (...) (Kidney International (2023))

2 March

Kidney Int http://www.kidney-international.org/

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  Drug repurposing in autosomal dominant polycystic kidney disease - Julie Xia Zhou, Vicente E. Torres Kidney Int
  Autosomal dominant polycystic kidney disease is characterized by progressive kidney cyst formation that leads to kidney failure. Tolvaptan, a vasopressin 2 receptor antagonist, is the only drug approved to treat patients with autosomal dominant polycystic kidney disease who have rapid disease (...) (Kidney International (2023))

1 March

Kidney Int http://www.kidney-international.org/

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  The ASCEND-NHQ trial found positive effects of daprodustat on hemoglobin and quality of life in patients with non-dialysis-dependent chronic kidney disease - Kirsten L. Johansen, Alexander R. Cobitz, Ajay K. Singh, Iain C. Macdougall, Renato D. Lopes, Gregorio T. Obrador, Csaba P. Kovesdy, Rubeen Israni, Vivekanand Jha, Tony Okoro, Mike Sprys, Shivinder Jolly, Alistair C. Lindsay, Purav Bhatt, Rodrigo Refoios Camejo, Tom Keeley, Borut Cizman, David C. Wheeler Kidney Int
  The ASCEND-NHQ trial evaluated the effects of daprodustat on hemoglobin and the Medical Outcomes Study 36-item Short Form Survey (SF-36) Vitality score (fatigue) in a multicenter, randomized, double-blind, placebo-controlled trial. Adults with chronic kidney disease (CKD) Stages 3–5, hemoglobin (...) (Kidney International (2023))

27 February

Kidney Int http://www.kidney-international.org/

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  Single nuclei transcriptomics delineates complex immune and kidney cell interactions contributing to kidney allograft fibrosis - Jennifer M. McDaniels, Amol C. Shetty, Cem Kuscu, Canan Kuscu, Elissa Bardhi, Thomas Rousselle, Cinthia Drachenberg, Manish Talwar, James D. Eason, Thangamani Muthukumar, Daniel G. Maluf, Valeria R. Mas Kidney Int
  Chronic allograft dysfunction (CAD), characterized histologically by interstitial fibrosis and tubular atrophy, is the major cause of kidney allograft loss. Here, using single nuclei RNA sequencing and transcriptome analysis, we identified the origin, functional heterogeneity, and regulation of (...) (Kidney International (2023))