15 March

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney - Hülya Bay?r, Scott J. Dixon, Yulia Y. Tyurina, John A. Kellum, Valerian E. Kagan Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 15 March 2023; doi:10.1038/s41581-023-00689-xFerroptosis is an iron-dependent mechanism of regulated necrosis that is driven by the robust oxidation of polyunsaturated fatty acid-containing phospholipids. This Review describes the fundamental (...) (Nature Reviews Nephrology, Published online: 2023-03-15; | doi:10.1038/s41581-023-00689-x)

13 March

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  The cilia mechanosensation debate gets (bio)physical - Dagmar Wachten, Pleasantine Mill Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 13 March 2023; doi:10.1038/s41581-023-00701-4Two studies have applied a mechanical stimulus directly to a cilium, independent of a chemical signal, and demonstrated that force-based bending of a single nodal axoneme is sufficient to induce (...) (Nature Reviews Nephrology, Published online: 2023-03-13; | doi:10.1038/s41581-023-00701-4)

9 March

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  The role of lysosomes in metabolic and autoimmune diseases - Frédéric Gros, Sylviane Muller Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 09 March 2023; doi:10.1038/s41581-023-00692-2In this Review, the authors describe the roles of lysosomes in cellular clearance, autophagy, cell signalling, nutrient sensing and metabolic adaptation. They also discuss lysosome abnormalities in (...) (Nature Reviews Nephrology, Published online: 2023-03-09; | doi:10.1038/s41581-023-00692-2)

27 February

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Mechanism of B cell survival in lupus nephritis - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 27 February 2023; doi:10.1038/s41581-023-00696-yMechanism of B cell survival in lupus nephritis (Nature Reviews Nephrology, Published online: 2023-02-27; | doi:10.1038/s41581-023-00696-y)
• 00:00
  Experimental evidence for a pathogenic role of anti-PLA2R1 antibodies in membranous nephropathy - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 27 February 2023; doi:10.1038/s41581-023-00697-xExperimental evidence for a pathogenic role of anti-PLA2R1 antibodies in membranous nephropathy (Nature Reviews Nephrology, Published online: 2023-02-27; | doi:10.1038/s41581-023-00697-x)
• 00:00
  SGLT2 inhibitors attenuate alterations of kidney metabolic pathways in youth-onset T2DM - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 27 February 2023; doi:10.1038/s41581-023-00698-wSGLT2 inhibitors attenuate alterations of kidney metabolic pathways in youth-onset T2DM (Nature Reviews Nephrology, Published online: 2023-02-27; | doi:10.1038/s41581-023-00698-w)

23 February

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Targeting iron uptake to correct T cell dysfunction - Monica Wang Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 23 February 2023; doi:10.1038/s41581-023-00695-zTargeting iron uptake to correct T cell dysfunction (Nature Reviews Nephrology, Published online: 2023-02-23; | doi:10.1038/s41581-023-00695-z)
• 00:00
  Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup - Alexander Zarbock, Mitra K. Nadim, Peter Pickkers, Hernando Gomez, Samira Bell, Michael Joannidis, Kianoush Kashani, Jay L. Koyner, Neesh Pannu, Melanie Meersch, Thiago Reis, Thomas Rimmelé, Sean M. Bagshaw, Rinaldo Bellomo, Vicenzo Cantaluppi, Akash Deep, Silvia De Rosa, Xose Perez-Fernandez, Faeq Husain-Syed, Sandra L. Kane-Gill, Yvelynne Kelly, Ravindra L. Mehta, Patrick T. Murray, Marlies Ostermann, John Prowle, Zaccaria Ricci, Emily J. See, Antoine Schneider, Danielle E. Soranno, Ashita Tolwani, Gianluca Villa, Claudio Ronco, Lui G. (...) Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 23 February 2023; doi:10.1038/s41581-023-00683-3Sepsis-associated acute kidney injury (SA-AKI) is linked with poor outcomes in critically ill patients. This Consensus Statement from the Acute Disease Quality Initiative discusses the definition, (...) (Nature Reviews Nephrology, Published online: 2023-02-23; | doi:10.1038/s41581-023-00683-3)

17 February

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Reply to ‘Use of convalescent plasma in the treatment of COVID-19’ - Naoka Murakami, Robert Hayden, Thomas Hills, Hanny Al-Samkari, Jonathan Casey, Lorenzo Del Sorbo, Patrick R. Lawler, Meghan Sise, David E. Leaf Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 17 February 2023; doi:10.1038/s41581-023-00691-3Reply to ‘Use of convalescent plasma in the treatment of COVID-19’ (Nature Reviews Nephrology, Published online: 2023-02-17; | doi:10.1038/s41581-023-00691-3)
• 00:00
  Use of convalescent plasma in the treatment of COVID-19 - Michael J. Joyner, Nigel Paneth, Arturo Casadevall Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 17 February 2023; doi:10.1038/s41581-023-00690-4Use of convalescent plasma in the treatment of COVID-19 (Nature Reviews Nephrology, Published online: 2023-02-17; | doi:10.1038/s41581-023-00690-4)
• 00:00
  Bridging the gap of referral to nephrology care - Nestor Oliva-Damaso, Navdeep Tangri, Pierre Delanaye, Richard J. Glassock Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 17 February 2023; doi:10.1038/s41581-023-00693-1Optimal referral of patients who are at risk of kidney failure to nephrologists could improve their long-term outcomes. Various strategies, including the inclusion of kidney failure risk equations in (...) (Nature Reviews Nephrology, Published online: 2023-02-17; | doi:10.1038/s41581-023-00693-1)

6 February

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Author Correction: Therapeutic advances in COVID-19 - Naoka Murakami, Robert Hayden, Thomas Hills, Hanny Al-Samkari, Jonathan Casey, Lorenzo Del Sorbo, Patrick R. Lawler, Meghan E. Sise, David E. Leaf Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 February 2023; doi:10.1038/s41581-023-00686-0Author Correction: Therapeutic advances in COVID-19 (Nature Reviews Nephrology, Published online: 2023-02-06; | doi:10.1038/s41581-023-00686-0)
• 00:00
  Disaster preparedness for patients with kidney disease - Jeffrey B. Kopp, Kenneth Lempert, Kristen Finne Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 February 2023; doi:10.1038/s41581-023-00678-0Access to essential medical care can be compromised by social disruptions (such as riots and labour strikes), armed conflict and natural disasters, including extreme weather events. A successful (...) (Nature Reviews Nephrology, Published online: 2023-02-06; | doi:10.1038/s41581-023-00678-0)

31 January

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Fasting induces structural and functional changes in the peritoneal membrane - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 31 January 2023; doi:10.1038/s41581-023-00688-yFasting induces structural and functional changes in the peritoneal membrane (Nature Reviews Nephrology, Published online: 2023-01-31; | doi:10.1038/s41581-023-00688-y)

26 January

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Pathological consequences of DNA damage in the kidney - Juan I. Garaycoechea, Catherine Quinlan, Martijn S. Luijsterburg Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 26 January 2023; doi:10.1038/s41581-022-00671-zThe DNA damage response is essential to genomic stability. Here, the authors discuss DNA damage-induced nephrotoxicity and kidney cancer, and the essential role of DNA repair in kidney homeostasis, as (...) (Nature Reviews Nephrology, Published online: 2023-01-26; | doi:10.1038/s41581-022-00671-z)

24 January

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Targeting glutamine use in RCC - Monica Wang Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 24 January 2023; doi:10.1038/s41581-023-00684-2Targeting glutamine use in RCC (Nature Reviews Nephrology, Published online: 2023-01-24; | doi:10.1038/s41581-023-00684-2)
• 00:00
  VPS34 functions in the proximal tubule - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 24 January 2023; doi:10.1038/s41581-023-00685-1VPS34 functions in the proximal tubule (Nature Reviews Nephrology, Published online: 2023-01-24; | doi:10.1038/s41581-023-00685-1)

20 January

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Climate change-fuelled natural disasters and chronic kidney disease: a call for action - Amir Sapkota, Peter Kotanko Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 20 January 2023; doi:10.1038/s41581-023-00682-4People with kidney disease are particularly vulnerable to the impacts of natural disasters and extreme weather events. As climate change is increasing the frequency and severity of these events, a robust (...) (Nature Reviews Nephrology, Published online: 2023-01-20; | doi:10.1038/s41581-023-00682-4)
• 00:00
  Environmental pollution, heat stress and kidney health: a need for integrated assessment - Alison P. Sanders, Nishad Jayasundara Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 20 January 2023; doi:10.1038/s41581-023-00680-6Thousands of environmental chemicals are used globally. However, despite clear evidence of their adverse effects on the kidney, substantial knowledge gaps remain. Further studies are needed to better (...) (Nature Reviews Nephrology, Published online: 2023-01-20; | doi:10.1038/s41581-023-00680-6)
• 00:00
  Heat and health inequity: acting on determinants of health to promote heat justice - Jeremy Hess Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 20 January 2023; doi:10.1038/s41581-023-00679-zClimate change is increasing global temperatures and causing more frequent and severe extreme heat events. The resulting additional disease burden is inequitably distributed. Strategies that reduce (...) (Nature Reviews Nephrology, Published online: 2023-01-20; | doi:10.1038/s41581-023-00679-z)

19 January

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Consequences of famine and malnourishment on kidney health - Gerjan Navis Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 19 January 2023; doi:10.1038/s41581-023-00681-5Adequate nutrition is essential for kidney health; however, attempts to improve nutrition and food security have been hindered in recent years by man-made and natural disasters. Approaches to eradicate (...) (Nature Reviews Nephrology, Published online: 2023-01-19; | doi:10.1038/s41581-023-00681-5)
• 00:00
  Hope for resistant hypertension through BrigHTN and PRECISION - R. M. Touyz, D. G. Harrison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 19 January 2023; doi:10.1038/s41581-023-00676-2An estimated 10–15% of individuals with hypertension are resistant to available antihypertensive therapies. Findings from two new clinical trials — BrigHTN and PRECISION — that assessed the blood (...) (Nature Reviews Nephrology, Published online: 2023-01-19; | doi:10.1038/s41581-023-00676-2)

18 January

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Informing clinical decision making during a pandemic — a call for better preparedness - Priya Vart, Luuk B. Hilbrands, Ron T. Gansevoort Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 18 January 2023; doi:10.1038/s41581-023-00677-1The COVID-19 pandemic exposed flaws in the ability of the nephrology community to efficiently inform clinical decision making. To improve preparedness for the next pandemic, the nephrology community must (...) (Nature Reviews Nephrology, Published online: 2023-01-18; | doi:10.1038/s41581-023-00677-1)

17 January

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Exercise and chronic kidney disease: potential mechanisms underlying the physiological benefits - Nicolette C. Bishop, James O. Burton, Matthew P. M. Graham-Brown, David J. Stensel, João L. Viana, Emma L. Watson Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 17 January 2023; doi:10.1038/s41581-022-00675-9This Review discusses the potential mechanisms by which regular exercise has beneficial effects on chronic inflammation, cardiovascular health, lipid metabolism, insulin resistance, sarcopenia and bone (...) (Nature Reviews Nephrology, Published online: 2023-01-17; | doi:10.1038/s41581-022-00675-9)

16 January

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  The impact of intrauterine growth restriction and prematurity on nephron endowment - Megan R. Sutherland, Mary Jane Black Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 16 January 2023; doi:10.1038/s41581-022-00668-8Any processes that impair kidney development in the developing fetus can have lifelong adverse consequences for renal health. Here, the authors discuss the effects of preterm birth and/or intrauterine (...) (Nature Reviews Nephrology, Published online: 2023-01-16; | doi:10.1038/s41581-022-00668-8)

12 January

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  The role of immune cells and mediators in preeclampsia - Evangeline Deer, Owen Herrock, Nathan Campbell, Denise Cornelius, Sarah Fitzgerald, Lorena M. Amaral, Babbette LaMarca Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 12 January 2023; doi:10.1038/s41581-022-00670-0Immune dysregulation contributes to the pathogenesis of preeclampsia. Here, the authors examine the role of immune cells and mediators in driving the oxidative stress and endothelial dysfunction that (...) (Nature Reviews Nephrology, Published online: 2023-01-12; | doi:10.1038/s41581-022-00670-0)

11 January

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  The gut microbiome and hypertension - Joanne A. O’Donnell, Tenghao Zheng, Guillaume Meric, Francine Z. Marques Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 11 January 2023; doi:10.1038/s41581-022-00654-0The gut microbiota is increasingly recognized as an important factor in human health and disease. Here, the authors focus on the role of the gut microbiome in blood pressure regulation and discuss its (...) (Nature Reviews Nephrology, Published online: 2023-01-11; | doi:10.1038/s41581-022-00654-0)

9 January

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Regulation of FGF23 production and phosphate metabolism by bone–kidney interactions - Rafiou Agoro, Kenneth E. White Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 09 January 2023; doi:10.1038/s41581-022-00665-xIn this Review, the authors discuss the mineral-related factors and kidney-derived molecules that regulate osteocyte FGF23 production in health and disease. They also highlight potential approaches to (...) (Nature Reviews Nephrology, Published online: 2023-01-09; | doi:10.1038/s41581-022-00665-x)

5 January

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Clinical practice recommendations for primary hyperoxaluria: an expert consensus statement from ERKNet and OxalEurope - Jaap W. Groothoff, Ella Metry, Lisa Deesker, Sander Garrelfs, Cecile Acquaviva, Reham Almardini, Bodo B. Beck, Olivia Boyer, Rimante Cerkauskiene, Pietro Manuel Ferraro, Luitzen A. Groen, Asheeta Gupta, Bertrand Knebelmann, Giorgia Mandrile, Shabbir S. Moochhala, Agnieszka Prytula, Jovana Putnik, Gill Rumsby, Neveen A. Soliman, Bhaskar Somani, Justine Bacchetta Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 05 January 2023; doi:10.1038/s41581-022-00661-1Primary hyperoxaluria is an inherited disorder that results from the overproduction of endogenous oxalate, leading to recurrent kidney stones, nephrocalcinosis, kidney failure and life-threatening (...) (Nature Reviews Nephrology, Published online: 2023-01-05; | doi:10.1038/s41581-022-00661-1)

3 January

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Role of necroptosis in kidney health and disease - Benedikt Kolbrink, Friedrich A. von Samson-Himmelstjerna, James M. Murphy, Stefan Krautwald Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 03 January 2023; doi:10.1038/s41581-022-00658-wNecroptosis is a form of necrotic cell death that leads to cell lysis and an inflammatory response in neighbouring tissues. This Review describes the molecular mechanisms that regulate the induction of (...) (Nature Reviews Nephrology, Published online: 2023-01-03; | doi:10.1038/s41581-022-00658-w)
• 00:00
  Gasdermins and pyroptosis in the kidney - Esteban E. Elias, Brayden Lyons, Daniel A. Muruve Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 03 January 2023; doi:10.1038/s41581-022-00662-0Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-forming gasdermin family of proteins. Here, the authors provide an overview of the basic biology of (...) (Nature Reviews Nephrology, Published online: 2023-01-03; | doi:10.1038/s41581-022-00662-0)

19 December

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Insights into glomerular function and disease pathogenesis - Emelie Lassén, Ilse S. Daehn Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 19 December 2022; doi:10.1038/s41581-022-00667-9More than three-quarters of cases of chronic kidney disease are caused by glomerular diseases with glomerulosclerosis, including diabetic kidney disease, hypertensive nephropathy and glomerulonephritis. (...) (Nature Reviews Nephrology, Published online: 2022-12-19; | doi:10.1038/s41581-022-00667-9)
• 00:00
  Glucocorticoids block T cell recruitment - Monica Wang Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 19 December 2022; doi:10.1038/s41581-022-00674-wGlucocorticoids block T cell recruitment (Nature Reviews Nephrology, Published online: 2022-12-19; | doi:10.1038/s41581-022-00674-w)
• 00:00
  Paths to organ damage and risk factors in AKI - Marlies Ostermann, Mitchell H. Rosner Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 19 December 2022; doi:10.1038/s41581-022-00669-7Acute kidney injury (AKI) is a multifactorial syndrome with a complex pathophysiology including different inflammatory cells and mediators. Current research focuses on identifying key contributing (...) (Nature Reviews Nephrology, Published online: 2022-12-19; | doi:10.1038/s41581-022-00669-7)

16 December

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Iron deficiency of kidney macrophages in CKD - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 16 December 2022; doi:10.1038/s41581-022-00672-yIron deficiency of kidney macrophages in CKD (Nature Reviews Nephrology, Published online: 2022-12-16; | doi:10.1038/s41581-022-00672-y)
• 00:00
  Insights into the impact of pregnancy on kidney disease - Erandi Hewawasam, Shilpanjali Jesudason Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 16 December 2022; doi:10.1038/s41581-022-00663-zStudies in 2022 have advanced knowledge of pregnancy outcomes in kidney donors and transplant recipients as well as the long-term risks associated with hypertensive disorders of pregnancy. These (...) (Nature Reviews Nephrology, Published online: 2022-12-16; | doi:10.1038/s41581-022-00663-z)

14 December

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  The evolving landscape of immune-mediated glomerular diseases - Abdullah Jalal, Tingting Li Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 14 December 2022; doi:10.1038/s41581-022-00666-wOver the past year, trial data have emerged on therapeutic interventions in IgA nephropathy and lupus nephritis, including the effects of different doses of glucocorticoids and several novel targeted (...) (Nature Reviews Nephrology, Published online: 2022-12-14; | doi:10.1038/s41581-022-00666-w)

13 December

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Efficacy of empagliflozin for syndrome of inappropriate antidiuresis - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 13 December 2022; doi:10.1038/s41581-022-00673-xEfficacy of empagliflozin for syndrome of inappropriate antidiuresis (Nature Reviews Nephrology, Published online: 2022-12-13; | doi:10.1038/s41581-022-00673-x)

6 December

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Progress towards solving the donor organ shortage - Douglas J. Anderson, Jayme E. Locke Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 December 2022; doi:10.1038/s41581-022-00664-yKidney transplantation is the best therapy for kidney failure, but is limited by donor organ availability and the risks associated with immunosuppression. Studies in 2022 provided encouraging data about (...) (Nature Reviews Nephrology, Published online: 2022-12-06; | doi:10.1038/s41581-022-00664-y)

26 July

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  UTX regulates accumulation of lipids via kidney serine - Monica Wang Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 26 July 2022; doi:10.1038/s41581-022-00615-7UTX regulates accumulation of lipids via kidney serine (Nature Reviews Nephrology, Published online: 2022-07-26; | doi:10.1038/s41581-022-00615-7)

25 July

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Unmet care needs of minority groups on dialysis - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 25 July 2022; doi:10.1038/s41581-022-00614-8Unmet care needs of minority groups on dialysis (Nature Reviews Nephrology, Published online: 2022-07-25; | doi:10.1038/s41581-022-00614-8)
• 00:00
  Stem cell–kidney transplantation in Schimke immuno-osseous dysplasia - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 25 July 2022; doi:10.1038/s41581-022-00613-9Stem cell–kidney transplantation in Schimke immuno-osseous dysplasia (Nature Reviews Nephrology, Published online: 2022-07-25; | doi:10.1038/s41581-022-00613-9)
• 00:00
  Determining treatment response in lupus nephritis - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 25 July 2022; doi:10.1038/s41581-022-00611-xDetermining treatment response in lupus nephritis (Nature Reviews Nephrology, Published online: 2022-07-25; | doi:10.1038/s41581-022-00611-x)
• 00:00
  Quantifying access to transplantation - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 25 July 2022; doi:10.1038/s41581-022-00612-wQuantifying access to transplantation (Nature Reviews Nephrology, Published online: 2022-07-25; | doi:10.1038/s41581-022-00612-w)

22 July

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Principles of human and mouse nephron development - Jack Schnell, MaryAnne Achieng, Nils Olof Lindström Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 22 July 2022; doi:10.1038/s41581-022-00598-5Our understanding of nephrogenesis has been aided by studies that have compared features of human and mouse nephrogenesis, and by technological advances in single-cell omics and high-resolution imaging (...) (Nature Reviews Nephrology, Published online: 2022-07-22; | doi:10.1038/s41581-022-00598-5)

7 July

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Immunometabolic rewiring of tubular epithelial cells in kidney disease - Sanne van der Rijt, Jaklien C. Leemans, Sandrine Florquin, Riekelt H. Houtkooper, Alessandra Tammaro Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 07 July 2022; doi:10.1038/s41581-022-00592-xThe interplay between immunological and metabolic processes is important in a variety of processes. This Review describes how changes in lipid and energy metabolism, driven by receptors of the innate immune (...) (Nature Reviews Nephrology, Published online: 2022-07-07; | doi:10.1038/s41581-022-00592-x)

5 July

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Insights into basement membrane complexity - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 05 July 2022; doi:10.1038/s41581-022-00605-9Insights into basement membrane complexity (Nature Reviews Nephrology, Published online: 2022-07-05; | doi:10.1038/s41581-022-00605-9)
• 00:00
  A single-cell atlas of DKD treatment responses - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 05 July 2022; doi:10.1038/s41581-022-00603-xA single-cell atlas of DKD treatment responses (Nature Reviews Nephrology, Published online: 2022-07-05; | doi:10.1038/s41581-022-00603-x)
• 00:00
  Benefits of CoQ10 supplementation in patients with SRNS due to primary CoQ10 deficiency - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 05 July 2022; doi:10.1038/s41581-022-00604-wBenefits of CoQ10 supplementation in patients with SRNS due to primary CoQ10 deficiency (Nature Reviews Nephrology, Published online: 2022-07-05; | doi:10.1038/s41581-022-00604-w)
• 00:00
  Kidney xenotransplantation without acute rejection - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 05 July 2022; doi:10.1038/s41581-022-00602-yKidney xenotransplantation without acute rejection (Nature Reviews Nephrology, Published online: 2022-07-05; | doi:10.1038/s41581-022-00602-y)

4 July

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  The fibrogenic niche in kidney fibrosis: components and mechanisms - Li Li, Haiyan Fu, Youhua Liu Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 04 July 2022; doi:10.1038/s41581-022-00590-zThe fibrogenic niche is a unique tissue microenvironment that promotes fibroblast activation in organ fibrosis. This Review discusses the composition, function and mechanisms of action of the fibrogenic (...) (Nature Reviews Nephrology, Published online: 2022-07-04; | doi:10.1038/s41581-022-00590-z)

24 June

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Salt substitution: opportunities and challenges for nephrology - Ewout J. Hoorn, Matti Marklund, Jason H. Y. Wu Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 24 June 2022; doi:10.1038/s41581-022-00599-4Salt substitution — the partial replacement of sodium with potassium in table salt — is emerging as a powerful public health strategy to reduce hypertension and related diseases. Here, we explore whether salt (...) (Nature Reviews Nephrology, Published online: 2022-06-24; | doi:10.1038/s41581-022-00599-4)

22 June

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Role of the cGAS–STING pathway in systemic and organ-specific diseases - Sladjana Skopelja-Gardner, Jie An, Keith B. Elkon Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 22 June 2022; doi:10.1038/s41581-022-00589-6The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway not only is involved in host defence against infection but can lead to immune dysregulation. Here, the authors examine the (...) (Nature Reviews Nephrology, Published online: 2022-06-22; | doi:10.1038/s41581-022-00589-6)

20 June

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  The effect of HIF on metabolism and immunity - Cormac T. Taylor, Carsten C. Scholz Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 20 June 2022; doi:10.1038/s41581-022-00587-8Hypoxia-dependent changes in cellular metabolism have important implications for the effective functioning of multiple immune cell subtypes. This Review describes the inputs that shape the hypoxic response (...) (Nature Reviews Nephrology, Published online: 2022-06-20; | doi:10.1038/s41581-022-00587-8)

15 June

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Basophils stoke the fire - Monica Wang Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 15 June 2022; doi:10.1038/s41581-022-00597-6Basophils stoke the fire (Nature Reviews Nephrology, Published online: 2022-06-15; | doi:10.1038/s41581-022-00597-6)

6 June

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Synchronization in the renal microcirculation - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00595-8Synchronization in the renal microcirculation (Nature Reviews Nephrology, Published online: 2022-06-06; | doi:10.1038/s41581-022-00595-8)
• 00:00
  P3H2 in glomerular basement membrane regulation - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00594-9P3H2 in glomerular basement membrane regulation (Nature Reviews Nephrology, Published online: 2022-06-06; | doi:10.1038/s41581-022-00594-9)
• 00:00
  Important roles of mechanical force and hydraulic pressure in kidney function - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00593-wImportant roles of mechanical force and hydraulic pressure in kidney function (Nature Reviews Nephrology, Published online: 2022-06-06; | doi:10.1038/s41581-022-00593-w)
• 00:00
  Dietary protection of proximal tubules in diabetes - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00591-yDietary protection of proximal tubules in diabetes (Nature Reviews Nephrology, Published online: 2022-06-06; | doi:10.1038/s41581-022-00591-y)
• 00:00
  Benefits of actin cytoskeleton stabilization - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00596-7Benefits of actin cytoskeleton stabilization (Nature Reviews Nephrology, Published online: 2022-06-06; | doi:10.1038/s41581-022-00596-7)
• 00:00
  Patient-centred clinical trial design - Allison Tong, Nicole Scholes-Robertson, Carmel Hawley, Andrea K. Viecelli, Simon A. Carter, Adeera Levin, Brenda R. Hemmelgarn, Tess Harris, Jonathan C. Craig Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00585-wMeaningful involvement of patients in clinical trial design could lead to improvements in participant recruitment and retention, the uptake of the tested intervention and the impact of the findings. Here, (...) (Nature Reviews Nephrology, Published online: 2022-06-06; | doi:10.1038/s41581-022-00585-w)

31 May

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Extracellular vesicles in kidney disease - Cristina Grange, Benedetta Bussolati Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 31 May 2022; doi:10.1038/s41581-022-00586-9In this Review, the authors discuss the roles of extracellular vesicles in kidney physiology and disease as well as the beneficial effects of stem cell-derived extracellular vesicles in preclinical models of (...) (Nature Reviews Nephrology, Published online: 2022-05-31; | doi:10.1038/s41581-022-00586-9)

30 May

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Continuing kidney care in conflicts - Raymond Vanholder, Anja De Weggheleire, Dmytro D. Ivanov, Valerie Luyckx, Slim Slama, Mohamed Sekkarie, Mehmet S. Sever, Rukshana Shroff Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 30 May 2022; doi:10.1038/s41581-022-00588-7The devastating effects of war are far-reaching and particularly affect people with kidney disease. The Ukrainian conflict has highlighted problems encountered in the provision of support for this vulnerable (...) (Nature Reviews Nephrology, Published online: 2022-05-30; | doi:10.1038/s41581-022-00588-7)
• 00:00
  Cardiac metabolic remodelling in chronic kidney disease - Nikayla Patel, Muhammad Magdi Yaqoob, Dunja Aksentijevic Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 30 May 2022; doi:10.1038/s41581-022-00576-xChronic kidney disease is associated with an increased risk of cardiovascular disease, such as heart failure. Here, the authors examine myocardial metabolic remodelling in chronic kidney disease, including (...) (Nature Reviews Nephrology, Published online: 2022-05-30; | doi:10.1038/s41581-022-00576-x)

20 May

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Bringing Pride to nephrology Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 20 May 2022; doi:10.1038/s41581-022-00584-xJune marks Pride Month — an event that aims to recognize and celebrate LGBTQ+ communities worldwide. However, it also provides an opportunity to highlight the challenges that LGBTQ+ colleagues and nephrology (...) (Nature Reviews Nephrology, Published online: 2022-05-20; | doi:10.1038/s41581-022-00584-x)

6 May

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Transcatheter mitral valve repair in patients with CKD - Wendy McCallum, Mark J. Sarnak Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 May 2022; doi:10.1038/s41581-022-00583-yA post hoc analysis of the COAPT trial suggests that transcatheter mitral valve repair for secondary mitral regurgitation is efficacious in patients with heart failure and chronic kidney disease. The (...) (Nature Reviews Nephrology, Published online: 2022-05-06; | doi:10.1038/s41581-022-00583-y)
• 00:00
  Interferon blockade in lupus: effects on antiviral immunity - Stefanie Steiger, Hans-Joachim Anders Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 May 2022; doi:10.1038/s41581-022-00581-0Targeting type I interferon immune responses is a potential strategy for the treatment of systemic lupus erythematosus. Although a phase 2 clinical trial of anifrolumab did not meet its primary end point, (...) (Nature Reviews Nephrology, Published online: 2022-05-06; | doi:10.1038/s41581-022-00581-0)

4 May

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  mTORC1 under the control of CB1R - Monica Wang Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 04 May 2022; doi:10.1038/s41581-022-00582-zmTORC1 under the control of CB1R (Nature Reviews Nephrology, Published online: 2022-05-04; | doi:10.1038/s41581-022-00582-z)

2 May

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Our commitment to rigorous, constructive and inclusive peer review Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 02 May 2022; doi:10.1038/s41581-022-00569-wAt Nature Reviews Nephrology, we believe that peer review should be a rigorous, constructive and inclusive process. We are working to meet this aim through several (...) (Nature Reviews Nephrology, Published online: 2022-05-02; | doi:10.1038/s41581-022-00569-w)

28 April

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  METTL3 contributes to the pathogenesis of AKI - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 28 April 2022; doi:10.1038/s41581-022-00579-8METTL3 contributes to the pathogenesis of AKI (Nature Reviews Nephrology, Published online: 2022-04-28; | doi:10.1038/s41581-022-00579-8)
• 00:00
  NUAK1 promotes kidney fibrosis - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 28 April 2022; doi:10.1038/s41581-022-00580-1NUAK1 promotes kidney fibrosis (Nature Reviews Nephrology, Published online: 2022-04-28; | doi:10.1038/s41581-022-00580-1)
• 00:00
  Treating mild chronic hypertension in pregnancy - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 28 April 2022; doi:10.1038/s41581-022-00578-9Treating mild chronic hypertension in pregnancy (Nature Reviews Nephrology, Published online: 2022-04-28; | doi:10.1038/s41581-022-00578-9)
• 00:00
  Role of glomerular endothelial cell fenestrations - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 28 April 2022; doi:10.1038/s41581-022-00577-wRole of glomerular endothelial cell fenestrations (Nature Reviews Nephrology, Published online: 2022-04-28; | doi:10.1038/s41581-022-00577-w)
• 00:00
  Membranous nephropathy: new pathogenic mechanisms and their clinical implications - Elion Hoxha, Linda Reinhard, Rolf A. K. Stahl Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 28 April 2022; doi:10.1038/s41581-022-00564-1Understanding of the pathogenesis of membranous nephropathy has improved substantially, thanks to the discovery of pathogenic circulating autoantibodies against endogenous antigens. This Review provides an (...) (Nature Reviews Nephrology, Published online: 2022-04-28; | doi:10.1038/s41581-022-00564-1)

26 April

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Advancing kidney health justice through gender-affirming care - Han E. Eckenrode, Joseph T. Flynn, Dinushika Mohottige Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 26 April 2022; doi:10.1038/s41581-022-00575-yAdvancing kidney health justice for all requires the kidney-care community to embrace gender-affirming care across the life course, including inclusion of gender minority individuals in research, (...) (Nature Reviews Nephrology, Published online: 2022-04-26; | doi:10.1038/s41581-022-00575-y)

22 April

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Artificial intelligence-enabled decision support in nephrology - Tyler J. Loftus, Benjamin Shickel, Tezcan Ozrazgat-Baslanti, Yuanfang Ren, Benjamin S. Glicksberg, Jie Cao, Karandeep Singh, Lili Chan, Girish N. Nadkarni, Azra Bihorac Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 22 April 2022; doi:10.1038/s41581-022-00562-3Emerging evidence suggests that artificial intelligence (AI)-enabled decision support systems may have an important role in the diagnosis, prognosis and treatment of kidney diseases. This Review provides (...) (Nature Reviews Nephrology, Published online: 2022-04-22; | doi:10.1038/s41581-022-00562-3)

20 April

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  The impact of the Russian–Ukrainian war for people with chronic diseases - Giorgina B. Piccoli, Giuliano Brunori, Loreto Gesualdo, Kamyar Kalantar-Zadeh Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 20 April 2022; doi:10.1038/s41581-022-00574-zPeople with chronic diseases are at high risk of becoming innocent victims of the Russian–Ukrainian war, owing to interruption of their health care. More than 10 million Ukrainian people have left their (...) (Nature Reviews Nephrology, Published online: 2022-04-20; | doi:10.1038/s41581-022-00574-z)
• 00:00
  Ensuring health equity for sexual and/or gender minority individuals - Juan D. Salcedo-Betancourt, Samira S. Farouk, Yuvaram N. V. Reddy Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 20 April 2022; doi:10.1038/s41581-022-00572-1People who identify as sexual and/or gender minority individuals face unique and challenging inequities in access to health care. They experience bias, discrimination and underinsurance, which limits their (...) (Nature Reviews Nephrology, Published online: 2022-04-20; | doi:10.1038/s41581-022-00572-1)

13 April

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Supporting sexual and gender minority health-care workers - Mackenzie H. Holmberg, Suzanne G. Martin, Mitchell R. Lunn Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 13 April 2022; doi:10.1038/s41581-022-00573-0Sexual and/or gender minority health-care workers are subject to the heteronormativity and cisnormativity of society and often face open discrimination. Empowering these individuals to bring their full, (...) (Nature Reviews Nephrology, Published online: 2022-04-13; | doi:10.1038/s41581-022-00573-0)
• 00:00
  COVID-19 and kidney disease: insights from epidemiology to inform clinical practice - Viyaasan Mahalingasivam, Guobin Su, Masao Iwagami, Mogamat Razeen Davids, James B. Wetmore, Dorothea Nitsch Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 13 April 2022; doi:10.1038/s41581-022-00570-3Patients with kidney disease are at particular risk of the adverse outcomes of COVID-19. Throughout the pandemic, epidemiological studies have been performed to inform clinical care; however, these studies (...) (Nature Reviews Nephrology, Published online: 2022-04-13; | doi:10.1038/s41581-022-00570-3)

12 April

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  COVID-19 vaccine hesitancy - Eve Dubé, Noni E. MacDonald Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 12 April 2022; doi:10.1038/s41581-022-00571-2The COVID-19 pandemic has highlighted the vital role of vaccination in preventing life-threatening diseases and improving global health. Understanding and addressing the concerns of vaccine-hesitant (...) (Nature Reviews Nephrology, Published online: 2022-04-12; | doi:10.1038/s41581-022-00571-2)

11 April

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Drosophila melanogaster: a simple genetic model of kidney structure, function and disease - Julian A. T. Dow, Matias Simons, Michael F. Romero Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 11 April 2022; doi:10.1038/s41581-022-00561-4Drosophila melanogaster can be a useful experimental model in nephrology. Here, the authors examine the fly renal system, focusing on the Malpighian tubules and nephrocytes, and discuss its advantages and (...) (Nature Reviews Nephrology, Published online: 2022-04-11; | doi:10.1038/s41581-022-00561-4)

1 April

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Glomerular hyperfiltration - Monica Cortinovis, Norberto Perico, Piero Ruggenenti, Andrea Remuzzi, Giuseppe Remuzzi Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 01 April 2022; doi:10.1038/s41581-022-00559-yHere, the authors describe the determinants of ‘absolute’ and ‘relative’ glomerular hyperfiltration and discuss single-nephron haemodynamic changes as pathophysiological factors that might result in (...) (Nature Reviews Nephrology, Published online: 2022-04-01; | doi:10.1038/s41581-022-00559-y)

28 March

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Kidney complications of parasitic diseases - Elizabeth De Francesco Daher, Geraldo Bezerra da Silva Junior, Mayuri Trivedi, Tarek Fayad, Nattachai Srisawat, Sanjeev Nair, Padet Siriyasatien, Marcus Vinícius Guimarães de Lacerda, Maria Alice Sperto Ferreira Baptista, Mahesha Vankalakunti, Vivekanand Jha Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 28 March 2022; doi:10.1038/s41581-022-00558-zIn this Review, the authors focus on kidney involvement in Chagas disease, filariasis, leishmaniasis, malaria and schistosomiasis. They describe the epidemiology, clinical features, mechanisms of kidney (...) (Nature Reviews Nephrology, Published online: 2022-03-28; | doi:10.1038/s41581-022-00558-z)
• 00:00
  A recombinant fusion protein clears IgA deposits - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 28 March 2022; doi:10.1038/s41581-022-00568-xA recombinant fusion protein clears IgA deposits (Nature Reviews Nephrology, Published online: 2022-03-28; | doi:10.1038/s41581-022-00568-x)

25 March

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  MICA in kidney transplants - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 25 March 2022; doi:10.1038/s41581-022-00563-2MICA in kidney transplants (Nature Reviews Nephrology, Published online: 2022-03-25; | doi:10.1038/s41581-022-00563-2)
• 00:00
  Role of pericytes in ischaemia–reperfusion injury - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 25 March 2022; doi:10.1038/s41581-022-00566-zRole of pericytes in ischaemia–reperfusion injury (Nature Reviews Nephrology, Published online: 2022-03-25; | doi:10.1038/s41581-022-00566-z)
• 00:00
  Circulating osteopontin mediates acute kidney injury-induced respiratory failure - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 25 March 2022; doi:10.1038/s41581-022-00567-yCirculating osteopontin mediates acute kidney injury-induced respiratory failure (Nature Reviews Nephrology, Published online: 2022-03-25; | doi:10.1038/s41581-022-00567-y)
• 00:00
  Anti-tumour antibody-producing plasma cells disseminate from tertiary lymphoid structures - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 25 March 2022; doi:10.1038/s41581-022-00565-0Anti-tumour antibody-producing plasma cells disseminate from tertiary lymphoid structures (Nature Reviews Nephrology, Published online: 2022-03-25; | doi:10.1038/s41581-022-00565-0)