27 March

Nature Reviews Nephrology http://www.nature.com/ncpneph/

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  Immunogenicity in renal cell carcinoma: shifting focus to alternative sources of tumour-specific antigens - Melissa M. Wolf, W. Kimryn Rathmell, Aguirre A. de Cubas Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 27 March 2023; doi:10.1038/s41581-023-00700-5Renal cell carcinoma is sensitive to immune checkpoint blockade despite having a moderate traditional tumour mutational burden profile. Here, the authors discuss how the high prevalence of frameshift (...) (Nature Reviews Nephrology, Published online: 2023-03-27; | doi:10.1038/s41581-023-00700-5)
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  HLA class II expression levels and alloimmune risk - Monica Wang Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 27 March 2023; doi:10.1038/s41581-023-00714-zHLA class II expression levels and alloimmune risk (Nature Reviews Nephrology, Published online: 2023-03-27; | doi:10.1038/s41581-023-00714-z)
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  Cell and gene therapy for kidney disease - Jennifer L. Peek, Matthew H. Wilson Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 27 March 2023; doi:10.1038/s41581-023-00702-3Despite advances in cell and gene therapy for the treatment of disease, no such interventions currently target the kidney. Here, the authors review the potential for cell and gene therapies to be applied (...) (Nature Reviews Nephrology, Published online: 2023-03-27; | doi:10.1038/s41581-023-00702-3)

24 March

Nature Reviews Nephrology http://www.nature.com/ncpneph/

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  Phosphate sensing via PTC glycolysis - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 24 March 2023; doi:10.1038/s41581-023-00710-3Phosphate sensing via PTC glycolysis (Nature Reviews Nephrology, Published online: 2023-03-24; | doi:10.1038/s41581-023-00710-3)
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  Pharmacogenomics in the clinic - Monica Wang Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 24 March 2023; doi:10.1038/s41581-023-00709-wPharmacogenomics in the clinic (Nature Reviews Nephrology, Published online: 2023-03-24; | doi:10.1038/s41581-023-00709-w)
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  Blockchain in nephrology - Tamas Szili-Torok, Daan Kremer, Stephan J. L. Bakker, Uwe J. F. Tietge, Martin H. de Borst Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 24 March 2023; doi:10.1038/s41581-023-00707-yBlockchains enable secure data storage, the verification of data origin and accurate registration of changes in information over time. The widespread adoption of blockchain in nephrology could affect (...) (Nature Reviews Nephrology, Published online: 2023-03-24; | doi:10.1038/s41581-023-00707-y)

23 March

Nature Reviews Nephrology http://www.nature.com/ncpneph/

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  Regulated cell death pathways in kidney disease - Ana B. Sanz, Maria Dolores Sanchez-Niño, Adrian M. Ramos, Alberto Ortiz Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 23 March 2023; doi:10.1038/s41581-023-00694-0Pathways of regulated cell death may contribute to the pathogenesis of various kidney diseases. Here, the authors provide an overview of the relationship between necroptosis, pyroptosis, ferroptosis and (...) (Nature Reviews Nephrology, Published online: 2023-03-23; | doi:10.1038/s41581-023-00694-0)

22 March

Nature Reviews Nephrology http://www.nature.com/ncpneph/

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  Intradialytic acute brain injury - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 22 March 2023; doi:10.1038/s41581-023-00708-xIntradialytic acute brain injury (Nature Reviews Nephrology, Published online: 2023-03-22; | doi:10.1038/s41581-023-00708-x)

15 March

Nature Reviews Nephrology http://www.nature.com/ncpneph/

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  Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney - Hülya Bay?r, Scott J. Dixon, Yulia Y. Tyurina, John A. Kellum, Valerian E. Kagan Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 15 March 2023; doi:10.1038/s41581-023-00689-xFerroptosis is an iron-dependent mechanism of regulated necrosis that is driven by the robust oxidation of polyunsaturated fatty acid-containing phospholipids. This Review describes the fundamental (...) (Nature Reviews Nephrology, Published online: 2023-03-15; | doi:10.1038/s41581-023-00689-x)

13 March

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  The cilia mechanosensation debate gets (bio)physical - Dagmar Wachten, Pleasantine Mill Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 13 March 2023; doi:10.1038/s41581-023-00701-4Two studies have applied a mechanical stimulus directly to a cilium, independent of a chemical signal, and demonstrated that force-based bending of a single nodal axoneme is sufficient to induce (...) (Nature Reviews Nephrology, Published online: 2023-03-13; | doi:10.1038/s41581-023-00701-4)

9 March

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  The role of lysosomes in metabolic and autoimmune diseases - Frédéric Gros, Sylviane Muller Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 09 March 2023; doi:10.1038/s41581-023-00692-2In this Review, the authors describe the roles of lysosomes in cellular clearance, autophagy, cell signalling, nutrient sensing and metabolic adaptation. They also discuss lysosome abnormalities in (...) (Nature Reviews Nephrology, Published online: 2023-03-09; | doi:10.1038/s41581-023-00692-2)