12:42Prediction of Prehospital Change of the Cardiac Rhythm From Nonshockable to Shockable in Out?of?Hospital Patients With Cardiac Arrest: A Post Hoc Analysis of a Nationwide, Multicenter, Prospective Registry -
Ryo Emoto, Mitsuaki Nishikimi , Muhammad Shoaib , Kei Hayashida , Kazuki Nishida , Kazuya Kikutani , Shinichiro Ohshimo , Shigeyuki Matsui , Nobuaki Shime , and Taku Iwami 1 Department of Biostatistics Nagoya University Graduate School of Medicine Nagoya Japan 2 Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan 3 Department of Emergency and Critical Care Medicine Nagoya University Graduate School of Medicine Nagoya Japan 4 Laboratory for Critical Care Physiology The Feinstein Institutes for Medical (...)
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundPredicting a spontaneous rhythm change from nonshockable to shockable before hospital arrival in patients with out?of?hospital cardiac arrest can help emergency medical services develop better strategies for (...) (Journal of the American Heart Association)
12:41
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundThere is little evidence on the relationship between statin use and the risk of hospitalization attributable to COVID?19.Methods and ResultsThe French National Healthcare Data System database was used to (...) (Journal of the American Heart Association)
12:41
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundHypertension and diabetes disproportionately affect older non?Hispanic Black and Hispanic adults in the United States. Chronic stress may partially explain these disparities. This study identified underlying (...) (Journal of the American Heart Association)
12:40
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundImproved prediction of atrial fibrillation (AF) may allow for earlier interventions for stroke prevention, as well as mortality and morbidity from other AF?related complications. We developed a clinically (...) (Journal of the American Heart Association)
12:38Histone Deacetylase 6 Inhibitor JS28 Prevents Pathological Gene Expression in Cardiac Myocytes -
Vivien Ngo, Bernd K. Fleischmann , Manfred Jung , Lutz Hein , and Achim Lother 1 Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine University of Freiburg Germany 2 Institute of Physiology I, Life & Brain Center, Medical Faculty University of Bonn Germany 3 Institute of Pharmaceutical Sciences University of Freiburg Germany 4 BIOSS Centre for Biological Signaling Studies University of Freiburg Germany 5 Interdisciplinary Medical Intensive Care (IMIT), Medical Center – University of Freiburg, Faculty of Medicine University of Freiburg (...)
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundEpigenetic modulators have been proposed as promising new drug targets to treat adverse remodeling in heart failure. Here, we evaluated the potential of 4 epigenetic drugs, including the recently developed (...) (Journal of the American Heart Association)
12:38
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundPrior studies have reported disparities by race in the management of acute myocardial infarction (MI), with many studies having limited covariates or now dated. We examined racial and ethnic differences in (...) (Journal of the American Heart Association)
12:38Interaction Between Race, Ethnicity, Severe Mental Illness, and Cardiovascular Disease -
Kevin O'Gallagher, James TH. Teo , Ajay M. Shah , and Fiona Gaughran 1 British Heart Foundation Centre of Research Excellence King’s College London London United Kingdom 2 King’s College Hospital NHS Foundation Trust London United Kingdom 3 Institute of Psychiatry, Psychology and Neuroscience King’s College London London United Kingdom 4 South London and Maudsley NHS Foundation Trust London United Kingdom
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. Severe mental illnesses, such as schizophrenia or bipolar disorder, affect ?1% of the population who, as a group, experience significant disadvantage in terms of physical health and reduced life expectancy. In this (...) (Journal of the American Heart Association)
12:37Prognostic Value of Exercise Capacity in Kidney Transplant Candidates -
Sean Tan, Yi Wen Thang , William R. Mulley , Kevan R. Polkinghorne , Satish Ramkumar , Kevin Cheng , Jasmine Chan , John Galligan , Mark Nolan , Adam J. Brown , Stuart Moir , James D. Cameron , Stephen J. Nicholls , Philip M. Mottram , and Nitesh Nerlekar 1 Monash Cardiovascular Research Centre, Victorian Heart Institute Monash University Melbourne Victoria Australia 2 Monash Heart Monash Health Melbourne Victoria Australia 3 Department of Nephrology Monash Health Melbourne Victoria Australia 4 Department of Medicine Monash University Melbourne Victoria Australia 5 Baker Heart and (...)
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundExercise stress testing for cardiovascular assessment in kidney transplant candidates has been shown to be a feasible alternative to pharmacologic methods. Exercise stress testing allows the additional (...) (Journal of the American Heart Association)
12:37
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundThe small GTPase RhoA (Ras homolog gene family, member A) regulates a variety of cellular processes, including cell motility, proliferation, survival, and permeability. In addition, there are reports (...) (Journal of the American Heart Association)
12:37
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. (Journal of the American Heart Association)
12:37
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundExercise is associated with a reduced risk of cardiovascular disease. Increased high?density lipoprotein cholesterol (HDL?C) levels are thought to contribute to these benefits, but much of the research in (...) (Journal of the American Heart Association)
12:36Integrating a Polygenic Risk Score for Coronary Artery Disease as a Risk?Enhancing Factor in the Pooled Cohort Equation: A Cost?Effectiveness Analysis Study -
Deo Mujwara, Geoffrey Henno , Stephen T. Vernon , Siyang Peng , Paolo Di Domenico , Brock Schroeder , George B. Busby , Gemma A Figtree , and Giordano Bottà 1Allelica, Inc Wilmington DE 2 Illumina, Inc San Diego CA 3Kolling InstituteRoyal North Shore Hospital Sydney NSW Australia 4Charles Perkins CentreUniversity of Sydney NSW Australia 5Department of Cardiology Royal North Shore Hospital Sydney NSW Australia
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundCardiovascular diseases are the leading cause of death in the United States, yet a significant proportion of adults at high risk remain undetected by standard screening practices. Polygenic risk score for (...) (Journal of the American Heart Association)
12:36Sex?Specific Differences in Clinical Outcomes After Percutaneous Coronary Intervention: Insights from the TAILOR?PCI Trial -
Mina Madan, J. Dawn Abbott , Ryan Lennon , Derek Y. F. So , Andrea M. MacDougall , Mary Ann McLaughlin , Vishakantha Murthy , Jacqueline Saw , Charanjit Rihal , Michael E. Farkouh , Naveen L. Pereira , Shaun G. Goodman 1Schulich Heart CentreSunnybrook Health Sciences CentreUniversity of Toronto Toronto Ontario Canada 2Division of Cardiology Lifespan Cardiovascular Institute Warren Alpert Medical School of Brown University Providence RI 3Department of Quantitative Health Sciences Mayo Clinic Rochester MN 4University of Ottawa Heart Institute Ottawa Ontario Canada 5Thunder Bay Regional (...)
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundTAILOR?PCI (Tailored Antiplatelet Initiation to Lessen Outcomes due to decreased Clopidogrel Response After Percutaneous Coronary Intervention) studied genotype?guided selection of antiplatelet therapy after (...) (Journal of the American Heart Association)
12:35Sex?Based Differences in Outcomes Following Peripheral Artery Revascularization: Insights From VOYAGER PAD -
Connie N. Hess, Iris Baumgartner , Sonia S. Anand , Mark R. Nehler , Manesh R. Patel , E. Sebastian Debus , Michael Szarek , Warren Capell , Eva Muehlhofer , Scott D. Berkowitz , Lloyd P. Haskell , Rupert M. Bauersachs , Marc P. Bonaca , and Judith Hsia 1 Division of Cardiology, Department of Medicine University of Colorado School of Medicine Aurora CO 2 CPC Clinical Research Aurora CO 3 Division of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital University of Bern Switzerland 4 Population Health Research Institute, Hamilton Health Sciences McMaster (...)
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundDespite high female prevalence of peripheral artery disease (PAD), little is known about sex?based outcomes after lower extremity revascularization (LER) for symptomatic PAD. The effects of rivaroxaban (...) (Journal of the American Heart Association)
12:35Characterization of “ICU?30”: A Binary Composite Outcome for Neonates With Critical Congenital Heart Disease -
Monique M. Gardner, Garrett Keim , Jill Hsia , Anh D. Mai , J. William Gaynor , Andrew C. Glatz , and Nadir Yehya 1Division of Cardiac Critical Care Department of Anesthesiology and Critical Care The Children’s Hospital of PhiladelphiaPerelman School of Medicine at the University of Pennsylvania Philadelphia PA 2Division of Critical Care Department of Anesthesiology and Critical Care The Children’s Hospital of PhiladelphiaPerelman School of Medicine at the University of Pennsylvania Philadelphia PA 3Division of Cardiology Department of Pediatrics The Children’s Hospital of Philadelphia (...)
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundNeonates with heart disease requiring cardiopulmonary bypass surgery are at high risk for mortality and morbidity. As it is rare, short?term mortality is difficult to use as a primary outcome for clinical (...) (Journal of the American Heart Association)
12:34Aortic Dimensions Are Larger in Patients With Fibromuscular Dysplasia -
Arielle M. Schwartz, Esther Kim , Patrick Gleason , Xiaona Li , Yi?An Ko , and Bryan J Wells 1 Willis Hurst Internal Medicine Residency Program Emory University Atlanta GA 2 Division of Cardiovascular Medicine, Department of Medicine Vanderbilt University Medical Center Nashville NC 3 Division of Cardiology, Department of Medicine Emory University School of Medicine Atlanta GA 4 Department of Biostatistics and Bioinformatics, Rollins School of Public Health Emory University Atlanta (...)
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundFibromuscular dysplasia (FMD) is a disease of unknown etiology that causes stenosis, aneurysmal dilatation, and dissection of vascular beds. Known to affect medium?sized arteries, FMD is not typically (...) (Journal of the American Heart Association)
12:34
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundExtracellular vesicles (EVs) are a popular treatment candidate for myocardial injury. This work investigated the effects of mesenchymal stem cells (MSCs)–secreted EVs–derived miR?200b?3p on cardiomyocyte (...) (Journal of the American Heart Association)
12:34Systematic Review of Cerebral Phenotypes Associated With Monogenic Cerebral Small?Vessel Disease -
Ed Whittaker, Sophie Thrippleton , Liza Y. W. Chong , Victoria G. Collins , Amy C. Ferguson , David E. Henshall , Emily Lancastle , Tim Wilkinson , Blair Wilson , Kirsty Wilson , Cathie Sudlow , Joanna Wardlaw , and Kristiina Rannikmäe 1Medical School University of Edinburgh Edinburgh United Kingdom 2Centre for Medical Informatics Usher Institute University of Edinburgh Edinburgh United Kingdom 3Centre for Clinical Brain Sciences University of Edinburgh Edinburgh United Kingdom 4NHS Greater Glasgow and Clyde Glasgow United Kingdom 5NHS Lothian Edinburgh United Kingdom 6BHF Data Science (...)
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundCerebral small?vessel disease (cSVD) is an important cause of stroke and vascular dementia. Most cases are multifactorial, but an emerging minority have a monogenic cause. WhileNOTCH3is the best?known gene, (...) (Journal of the American Heart Association)
12:34Relative Contribution of Blood Pressure in Childhood, Young? and Mid?Adulthood to Large Artery Stiffness in Mid?Adulthood -
Yaxing Meng, Marie?Jeanne Buscot , Markus Juonala , Feitong Wu , Matthew K. Armstrong , Brooklyn J. Fraser , Katja Pahkala , Nina Hutri?Kähönen , Mika Kähönen , Tomi Laitinen , Jorma S. A. Viikari , Olli T. Raitakari , Costan G. Magnussen , and James E. Sharman 1Menzies Institute for Medical ResearchUniversity of Tasmania Hobart Australia 2Department of Medicine University of Turku Turku Finland 3Division of Medicine Turku University Hospital Turku Finland 4Research Centre of Applied and Preventive Cardiovascular Medicine University of Turku Turku Finland 5Centre for Population Health (...)
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundBlood pressure associates with arterial stiffness, but the contribution of blood pressure at different life stages is unclear. We examined the relative contribution of childhood, young? and mid?adulthood (...) (Journal of the American Heart Association)
12:33Corin Missense Variants, Blood Pressure, and Hypertension in 11 322 Black Individuals: Insights From REGARDS and the Jackson Heart Study -
Vibhu Parcha, Marguerite R. Irvin , Leslie A. Lange , Nicole D. Armstrong , Akhil Pampana , Mariah Meyer , Suzanne E. Judd , Garima Arora , and Pankaj Arora 1Division of Cardiovascular Disease University of Alabama at Birmingham Birmingham AL 2Department of Epidemiology University of Alabama at Birmingham Birmingham AL 3Division of Biomedical Informatics and Personalized Medicine Department of Medicine University of Colorado School of Medicine Aurora CO 4Department of Epidemiology University of Colorado School of Public Health Aurora CO 5Department of Biostatistics University of Alabama (...)
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundCorin enzyme contributes to the processing of inactive natriuretic peptides to bioactive hormones. In Black individuals, Corin gene variants (rs111253292 [Q568P] and rs75770792 [T555I]) have been previously (...) (Journal of the American Heart Association)
12:33Transcatheter Aortic Valve Implantation With and Without Resheathing and Repositioning: A Systematic Review and Meta?analysis -
Francesco Moroni, Lorenzo Azzalini , Lars Sondergaard , Guilherme F. Attizzani , Santiago García , Hani Jneid , Mamas A. Mamas , and Rodrigo Bagur 1Division of Cardiology Pauley Heart CenterVirginia Commonwealth University Richmond VA 2Division of Cardiology Department of Medicine University of Washington Seattle WA 3The Heart Centre, RigshospitaletCopenhagen University Hospital Copenhagen Denmark 4Harrington Heart and Vascular InstituteUniversity Hospitals Cleveland Medical Center Cleveland OH 5The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital Cincinnati OH (...)
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundThere is a concern that resheathing/repositioning of transcatheter heart valves during transcatheter aortic valve implantation (TAVI) may lead to an increased risk of periprocedural complications. We aimed (...) (Journal of the American Heart Association)
12:33Altered Cerebral Microstructure in Adults With Atrial Septal Defect and Ventricular Septal Defect Repaired in Childhood -
Benjamin Asschenfeldt, Lars Evald , Camilla Salvig , Johan Heiberg , Leif Østergaard , Simon Fristed Eskildsen , and Vibeke Elisabeth Hjortdal 1Department of Cardiothoracic & Vascular Surgery Aarhus University Hospital Denmark 2Center of Functionally Integrative Neuroscience Aarhus University Denmark 3Department of Clinical Medicine Aarhus University Denmark 4Hammel Neurorehabilitation Centre and University Research Clinic Denmark 5Neuroradiology Research Unit, Department of Radiology Aarhus University Hospital Denmark 6Department of Cardiothoracic Surgery, Rigshospitalet and Institute of (...)
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundDelayed brain development, brain injury, and neurodevelopmental disabilities are commonly observed in infants operated for complex congenital heart defect. Our previous findings of poorer neurodevelopmental (...) (Journal of the American Heart Association)
12:33Low?Density Lipoprotein Cholesterol Attributable Cardiovascular Disease Risk Is Sex Specific -
Arjen J. Cupido, Folkert W. Asselbergs , A. Floriaan Schmidt , and G. Kees Hovingh 1Department of Vascular Medicine Amsterdam University Medical Centerslocation AMCUniversity of Amsterdam Netherlands 2Department of Cardiology Division of Heart & Lungs University Medical Center UtrechtUtrecht University Utrecht the Netherlands 3Division of Cardiology Department of Medicine University of California, Los Angeles Los Angeles CA 4Faculty of Population Health Sciences Institute of Cardiovascular ScienceUniversity College London London United Kingdom 5Health Data Research UK and Institute of (...)
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundEpidemiological studies show that women are generally at lower risk for cardiovascular disease than men. Here, we investigated the sex?specific differential effect of genetically increased low?density (...) (Journal of the American Heart Association)
12:32
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundEvidence of scaled?up physical activity interventions is scarce. This study evaluates the uptake, engagement, and effectiveness of one such intervention program.Methods and ResultsThe program was open to (...) (Journal of the American Heart Association)
12:32Radiofrequency Catheter Ablation for Pediatric Atrioventricular Nodal Reentrant Tachycardia: Impact of Age on Procedural Methods and Durable Success -
Edward T. O’Leary, Jamie Harris , Kimberlee Gauvreau , Courtney Gentry , Audrey Dionne , Dominic J. Abrams , Mark E. Alexander , Vassilios J. Bezzerides , Elizabeth S. DeWitt , John K. Triedman , Edward P. Walsh , and Douglas Y. Mah 1Department of Cardiology Boston Children’s Hospital Boston MA 2Harvard Medical School Boston MA
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundCatheter?based slow?pathway modification (SPM) is the treatment of choice for symptomatic atrioventricular nodal reentrant tachycardia (AVNRT). We sought to investigate the interactions between patient age (...) (Journal of the American Heart Association)
12:32Association of Familial History of Diabetes, Hypertension, Dyslipidemia, Stroke, or Myocardial Infarction With Risk of Kawasaki Disease -
Ji Hee Kwak, Eun Kyo Ha , Ju Hee Kim , Hye Ryung Cha , Seung Won Lee , and Man Yong Han 1Department of Pediatrics Kangbuk Samsung HospitalSungkyunkwan University School of Medicine Seoul Korea 2Department of Pediatrics Kangnam Sacred Heart HospitalHallym University College of Medicine Seoul Korea 3Department of Pediatrics Kangdong Sacred Heart HospitalHallym University College of Medicine Seoul Korea 4Department of Data Science Sejong University College of Software Convergence Seoul Korea 5Department of Precision Medicine Sungkyunkwan University School of Medicine Suwon Korea 6Department (...)
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundThere are few studies on the association with Kawasaki disease in children and the family’s history of cardiovascular disease (CVD). The aim of this study was to identify the association of increased risks (...) (Journal of the American Heart Association)
12:32Correlation Between Cardiac Images, Biomarkers, and Amyloid Load in Wild?Type Transthyretin Amyloid Cardiomyopathy -
Mami Morioka, Seiji Takashio , Naoya Nakashima , Masato Nishi , Akira Fujiyama , Kyoko Hirakawa , Shinsuke Hanatani , Hiroki Usuku , Eiichiro Yamamoto , Masafumi Kidoh , Seitaro Oda , Kenichi Matsushita , Mitsuharu Ueda , and Kenichi Tsujita 1Departments of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto Japan 2Departments of Diagnostic Radiology Graduate School of Medical Sciences Kumamoto University Kumamoto Japan 3Departments of Neurology Graduate School of Medical Sciences Kumamoto University Kumamoto (...)
J Am Heart Assoc
Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundSeveral imaging parameters and biomarkers provide diagnostic and prognostic information for wild?type transthyretin amyloid cardiomyopathy. However, the relevance of these parameters and their association (...) (Journal of the American Heart Association)