243 posts

25 January

Hypertension https://www.ahajournals.org/

11:01
Sex Differences in Associations Between Socioeconomic Status and Incident Hypertension Among Chinese Adults - Han Ma Fangchao Liu Jianxin Li Jichun Chen Jie Cao Shufeng Chen Xiaoqing Liu Xueli Yang Keyong Huang Chong Shen Ling Yu Yingxin Zhao Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Jianfeng Huang Xiangfeng Lu Dongfeng Gu Department of Epidemiology, Key Laboratory of Cardiovascular Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing. China (H.M., F.L., J.L., J. Chen, J. Cao, S.C., K.H., L.Z., Y.L., J.H., X. Lu, D.G.). Division of Epidemiology, (...) Hypertension

Hypertension, Ahead of Print. Background:With rapid socioeconomic development and transition, associations between socioeconomic status (SES) and hypertension remained uncertain in China. We aimed to examine the health effects of SES on hypertension incidence and explore the sex differences (...) (Hypertension)
11:00
Use of Valsalva Maneuver to Detect Late-Onset Delayed Orthostatic Hypotension - Jin-Woo Park Luis E. Okamoto Sung-Hwan Kim Seol-Hee Baek Joo Hye Sung Namjoon Jeon Alfredo Gamboa Cyndya A. Shibao André Diedrich Byung-Jo Kim Italo Biaggioni Department of Neurology, Korea University Medicine, Seoul (J.-W.P., S.-H.K., S.-H.B., J.H.S., N.J., B.-J.K.). Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (J.-W.P., L.E.O., A.G., C.A.S., A.D., I.B.). BK21 FOUR Program in Learning Health Systems, Korea University, Seoul (B.-J.K.). Department of Biomedical Engineering, Vanderbilt University, Nashville, TN (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Standard autonomic testing includes a 10-minute head-up tilt table test to detect orthostatic hypotension. Although this test can detect delayed orthostatic hypotension (dOH) between 3 and 10 minutes of standing, it cannot detect late-onset dOH after 10 (...) (Hypertension)
11:00
Prediction Model Based on Easily Available Markers for Aberrant Cardiac Remodeling in Women After Pregnancy - Zenab Mohseni-Alsalhi Emma B.N.J. Janssen Jil Delmarque Sander M.J. van Kuijk Marc E.A. Spaanderman Chahinda Ghossein-Doha Department of Obstetrics and Gynecology, School for Oncology and Developmental Biology, GROW, Maastricht University Medical Center (MUMC+), The Netherlands. (Z.M.-A., E.B.N.J.J., J.D., M.E.A.S., C.G.-D.) Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center (MUMC+), The Netherlands. (S.M.J.v.K.) Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Preeclampsia is strongly associated with left ventricular concentric remodeling (LVCR) and left ventricular hypertrophy (LVH) up to 10 years after delivery. This predisposes to heart failure later in life. Adequate detection and prediction of LVCR or LVH (...) (Hypertension)
11:00
Hypertension and Cardiovascular Disease Risk Among Individuals With Versus Without HIV - Mohammed Siddiqui Lonnie Hannon Zhixin Wang Jessica Blair Suzanne Oparil Sonya L. Heath Edgar T. Overton Paul Muntner Department of Medicine, University of Alabama at Birmingham. (M.S., S.O., S.L.H., E.T.O.) Department of Health Behavior, University of Alabama at Birmingham. (L.H.) Department of Epidemiology, University of Alabama at Birmingham. (Z.W., J.B., P.M.) Hypertension

Hypertension, Ahead of Print. BACKGROUND:A high proportion of individuals with HIV have hypertension, and the incidence of cardiovascular disease (CVD) is high in individuals with HIV.METHODS:We determined if the association between hypertension and CVD, including acute myocardial infarction (...) (Hypertension)

23 January

Hypertension https://www.ahajournals.org/

11:01
Using Adult Ambulatory Blood Pressure Thresholds in Youth: Impact of Nocturnal Hypertension - Shannon M. Lyon Jacob Hartz Yisong Huang Ming Hui Chen Sarah D. de Ferranti Department of Cardiology, Boston Children’s Hospital and Harvard Medical School, MA (S.M.L., J.H., Y.H., M.H.C., S.D.d.F.). Hypertension

Hypertension, Ahead of Print. (Hypertension)
11:00
Diastolic Blood Pressure and Intensive Blood Pressure Control on Cognitive Outcomes: Insights From the SPRINT MIND Trial - Chao Jiang Sitong Li Yufeng Wang Yiwei Lai Yu Bai Manlin Zhao Liu He Yu Kong Xueyuan Guo Songnan Li Nian Liu Chenxi Jiang Ribo Tang Caihua Sang Deyong Long Xin Du Jianzeng Dong Craig S. Anderson Changsheng Ma Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University and National Clinical Research Center for Cardiovascular Diseases, Beijing, China (C.J., S.L., Y.W., Y.L., M.Z., L.H., Y.K., X.G., S.L., N.L., C.J., R.T., C.S., D.L., X.D., J.D., C.M.). School of Clinical Medicine, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China (Y.B.). (...) Hypertension

Hypertension, Ahead of Print. Background:The potential benefits or harms of intensive systolic blood pressure (BP) control on cognitive function and cerebral blood flow in individuals with low diastolic blood pressure (DBP) remain unclear.Methods:We conducted a post hoc analysis of the SPRINT (...) (Hypertension)

19 January

Hypertension https://www.ahajournals.org/

11:00
Genomic, Transcriptomic, and Proteomic Depiction of Induced Pluripotent Stem Cells–Derived Smooth Muscle Cells As Emerging Cellular Models for Arterial Diseases - Lu Liu Charlene Jouve Josephine Henry Takiy-Eddine Berrandou Jean-Sébastien Hulot Adrien Georges Nabila Bouatia-Naji Université Paris Cité, Inserm, PARCC, France (L.L., C.J., J.H., T.-E.B., J.-S.H., A.G., N.B.-N.) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Vascular smooth muscle cells (SMCs) plasticity is a central mechanism in cardiovascular health and disease. We aimed at providing cellular phenotyping, epigenomic and proteomic depiction of SMCs derived from induced pluripotent stem cells and evaluating (...) (Hypertension)

18 January

Hypertension https://www.ahajournals.org/

08:00
Time in Target Range: the Future of Assessing Adequacy of Blood Pressure Control? - Markus P. Schlaich Dobney Hypertension Centre, School of Medicine – Royal Perth Hospital Unit/Medical Research Foundation, University of Western Australia, Perth, Australia; Departments of Cardiology and Nephrology, Royal Perth Hospital, Perth, Australia; and Neurovascular Hypertension & Kidney Disease Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia. Hypertension

Hypertension, Volume 80, Issue 2, Page 314-315, February 1, 2023. (Hypertension)
08:00
De Novo Postpartum Hypertension: Is Pregnancy a Stress Test or Risk Factor? - Ayodeji A. Sanusi Rachel G. Sinkey Center for Women’s Reproductive Health, University of Alabama at Birmingham (A.A.S., R.G.S.). Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Alabama at Birmingham (A.A.S., R.G.S.). Hypertension

Hypertension, Volume 80, Issue 2, Page 288-290, February 1, 2023. (Hypertension)
08:00
Extracting Information From Sympathetic Nerve Traffic in Gestational Hypertension - Sarah L. Walton Kate M. Denton Monash Biomedicine Discovery Institute (S.L.W., K.M.D.), Monash University, Clayton, Victoria, Australia. Department of Physiology (S.L.W., K.M.D.), Monash University, Clayton, Victoria, Australia. Hypertension

Hypertension, Volume 80, Issue 2, Page 302-304, February 1, 2023. (Hypertension)

11 January

Hypertension https://www.ahajournals.org/

11:01
The Proportion of Dietary Salt Replaced With Potassium-Enriched Salt in the SSaSS: Implications for Scale-Up - Xuejun Yin Ellie Paige Maoyi Tian Qiang Li Liping Huang Jie Yu Anthony Rodgers Paul Elliott Yangfeng Wu Bruce Neal The George Institute for Global Health, University of New South Wales, Sydney, Australia (X.Y., E.P., M.T., Q.L., L.H., J.Y., A.R., B.N.). National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia (E.P.). School of Public Health, Harbin Medical University, China (M.T.). Department of Cardiology, Peking University Third Hospital, Beijing, China (J.Y.). School of Public Health, Imperial College London, UK (P.E., B.N.). Peking (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:The SSaSS (Salt Substitute and Stroke Study) recently reported definitive effects of a potassium-enriched salt on cardiovascular outcomes and death. Quantifying the amount of potassium-enriched salt used by trial participants is important for (...) (Hypertension)
11:00
Angiotensin II Type 1A Receptor Expressed in Smooth Muscle Cells is Required for Hypertensive Vascular Remodeling in Mice Infused With Angiotensin II - Keisuke Okuno Keiichi Torimoto Stephanie M. Cicalese Kyle Preston Victor Rizzo Tomoki Hashimoto Thomas M. Coffman Matthew A. Sparks Satoru Eguchi Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (K.O., K.T., S.M.C., K.P., V.R., S.E.). Barrow Aneurysm and AVM Research Center, Departments of Neurosurgery and Neurobiology, Barrow Neurological Institute, Phoenix, AZ (T.H.). Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC (T.M.C., M.A.S.). Program in Cardiovascular and Metabolic Disorders, Duke-NUS (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Ang II (angiotensin II) type 1 (AT1) receptors play a critical role in cardiovascular diseases such as hypertension. Rodents have 2 types of AT1receptor (AT1Aand AT1B) of which knock-inTagln-mediated smooth muscle AT1Asilencing attenuated Ang II–induced (...) (Hypertension)
11:00
Effects of Renal Denervation on Sympathetic Nerve Traffic and Correlates in Drug-Resistant and Uncontrolled Hypertension: A Systematic Review and Meta-Analysis - Annalisa Biffi Raffaella Dell’Oro Fosca Quarti-Trevano Cesare Cuspidi Giovanni Corrao Giuseppe Mancia Guido Grassi Department of Statistics and Quantitative Methods, University Milano-Bicocca, Italy. (A.B., G.C.) Na-National Centre for Healthcare Research and Pharmacoepidemiology, University Milano-Bicocca, Italy. (A.B., G.C.) Clinica Medica, Department of Medicine and Surgery, University Milano-Bicocca, Italy. (R.D.O., F.Q.-T., C.C., G.M., G.G.) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Whether and to what extent the reported blood pressure (BP) lowering effects of renal denervation (RDN) are associated with a central sympathoinhibition is controversial. We examined this issue by performing a meta-analysis of the microneurographic (...) (Hypertension)

10 January

Hypertension https://www.ahajournals.org/

11:00
Estimated Dietary and Health Impact of the World Health Organization’s Global Sodium Benchmarks on Packaged Foods in Australia: a Modeling Study - Kathy Trieu Daisy H. Coyle Emalie Rosewarne Maria Shahid Rain Yamamoto Chizuru Nishida Bruce Neal Feng J. He Matti Marklund Jason H.Y. Wu The George Institute for Global Health, University of New South Wales, Sydney, Australia (K.T., D.H.C., E.R., M.S., B.N., M.M., J.H.Y.W.). World Health Organization, Geneva, Switzerland (R.Y., C.N.). Department of Epidemiology and Biostatistics, Imperial College London, United Kingdom (B.N.). Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (F.J.H.). Johns (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:In 2021, the World Health Organization (WHO) set sodium benchmarks for packaged foods to guide countries in setting feasible and effective sodium reformulation programs. We modeled the dietary and health impact of full compliance with the WHO’s sodium (...) (Hypertension)

9 January

Hypertension https://www.ahajournals.org/

11:00
Cancer Therapy–Related Hypertension: A Scientific Statement From the American Heart Association - Jordana B. Cohen Nancy J. Brown Sherry-Ann Brown Susan Dent Daan C.H. van Dorst Sandra M. Herrmann Ninian N. Lang Gavin Y. Oudit Rhian M. Touyz Hypertension

Hypertension, Ahead of Print. Contemporary anticancer drugs have significantly improved cancer survival at the expense of cardiovascular toxicities, including heart disease, thromboembolic disease, and hypertension. One of the most common side effects of these drugs is hypertension, especially (...) (Hypertension)

6 January

Hypertension https://www.ahajournals.org/

11:00
Pathophysiology of the Nondipping Blood Pressure Pattern - Justine Huart Alexandre Persu Jean-Philippe Lengelé Jean-Marie Krzesinski François Jouret George Stergiou Division of Nephrology, University of Liège Hospital (ULiège CHU), University of Liège, Belgium (J.H., J.-M.K., F.J.). Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), Cardiovascular Sciences, University of Liège, Belgium (J.H., J.-M.K., F.J.). Division of Cardiology, Department of Cardiovascular Diseases, Cliniques Universitaires Saint-Luc and Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium (...) Hypertension

Hypertension, Ahead of Print. The nondipping blood pressure (BP) pattern corresponds to a disruption in the circadian BP rhythm with an insufficient decrease in BP levels during night-time sleep as observed using 24-hour ambulatory BP monitoring. Patients with nondipping BP pattern have poorer (...) (Hypertension)

5 January

Hypertension https://www.ahajournals.org/

11:00
Blood Pressure Levels, Cardiovascular Events, and Renal Outcomes in Chronic Kidney Disease Without Antihypertensive Therapy: A Nationwide Population-Based Cohort Study - Shujing Wu Mian Li Jieli Lu Xulei Tang Guixia Wang Ruizhi Zheng Jingya Niu Li Chen Yanan Huo Min Xu Tiange Wang Zhiyun Zhao Shuangyuan Wang Hong Lin Guijun Qin Li Yan Qin Wan Lulu Chen Lixin Shi Ruying Hu Qing Su Xuefeng Yu Yingfen Qin Gang Chen Zhengnan Gao Feixia Shen Zuojie Luo Yuhong Chen Yinfei Zhang Chao Liu Youmin Wang Shengli Wu Tao Yang Qiang Li Yiming Mu Jiajun Zhao Guang Ning Yufang Bi Weiqing Wang Yu Xu Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:High blood pressure (BP) is highly prevalent in patients with chronic kidney disease. However, the thresholds to initiate BP-lowering treatment in this population are unclear. We aimed to examine the associations between BP levels and clinical outcomes (...) (Hypertension)
11:00
Continuous Positive Airway Pressure for the Treatment of Supine Hypertension and Orthostatic Hypotension in Autonomic Failure - Luis E. Okamoto Jorge E. Celedonio Emily C. Smith Sachin Y. Paranjape Bonnie K. Black Amr Wahba Jin-Woo Park Cyndya A. Shibao André Diedrich Italo Biaggioni Vanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville. (L.E.O., J.E.C., E.C.S., S.Y.P., B.K.B., A.W., J.-W.P., C.A.S., A.D., I.B.) Department of Pharmacology, Vanderbilt University Medical Center, Nashville. (I.B.) Department of Biomedical Engineering, Vanderbilt University, Nashville, TN (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Supine hypertension affects most patients with orthostatic hypotension (OH) due to autonomic failure, but it is often untreated for fear of worsening OH. We hypothesized that increasing intrathoracic pressure with continuous positive airway pressure (...) (Hypertension)
11:00
Genetically Predicted Differences in Systolic Blood Pressure and Risk of Cardiovascular and Noncardiovascular Diseases: A Mendelian Randomization Study in Chinese Adults - Robert Clarke Neil Wright Robin Walters Wei Gan Yu Guo Iona Y. Millwood Ling Yang Yiping Chen Sarah Lewington Jun Lv Canqing Yu Daniel Avery Kuang Lin Kang Wang Richard Peto Rory Collins Liming Li Derrick A. Bennett Sarah Parish Zhengming Chen Clinical Trial Service Unit and Epidemiological Studies, Nuffield Department of Population Health, University of Oxford, United Kingdom (R. Clarke, N.W., R.W., I.Y.M., L.Y., Y.C., S.L., D.A., K.L., R.P., R. Collins, D.A.B., S.P., Z.C.). Medical Research Council, Population Health Research Unit, University of Oxford, United Kingdom (R. Clarke, R.W., (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Mendelian randomization studies of systolic blood pressure (SBP) can assess the shape and strength of the associations of genetically predicted differences in SBP with major disease outcomes and are less constrained by biases in observational analyses. (...) (Hypertension)
11:00
Effects of Blood Pressure and Arterial Stiffness on Retinal Neurodegeneration: Cross-Sectional and Longitudinal Evidence From UK Biobank and Chinese Cohorts - Yining Huang Yixiong Yuan Yujie Wang Ziwen Hui Xianwen Shang Yanping Chen Siran Zhang Huan Liao Yifan Chen Mingguang He Zhuoting Zhu Wei Wang State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China (Y.H., Y.Y., Yanping Chen, S.Z., M.H., W.W.). Nanshan School, Guangzhou Medical University, China (Y.H.). Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Hypertension might be a modifiable risk factor for neurodegeneration diseases. However, the associations between blood pressure (BP), arterial stiffness index and retinal neurodegeneration remain unclear.METHODS:This study used cross-sectional data from (...) (Hypertension)
11:00
Microcirculation and Physical Exercise In Hypertension - Carolina De Ciuceis Damiano Rizzoni Paolo Palatini Department of Clinical and Experimental Sciences, University of Brescia, Italy (C.D.C., D.R.). Division of Medicine, Spedali Civili di Brescia, Montichiari, Brescia, Italy (D.R.). Department of Medicine, University of Padova, Padua, Italy (P.P.). Hypertension

Hypertension, Ahead of Print. Hypertension is associated with important alterations in the morphology of small arteries and arterioles. Vascular-specific manifestations are changes in the structure and function of vascular smooth muscle cells, extracellular matrix, perivascular tissues, and (...) (Hypertension)

30 December

Hypertension https://www.ahajournals.org/

11:01
Recent Advances in Hypertension: Epigenetic Mechanism Involved in Development of Salt-Sensitive Hypertension - Toshiro Fujita Division of Clinical Epigenetics, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Japan. Shinshu University, School of Medicine, Matsumoto, Japan. Research Center for Social Systems, Shinshu University, Matsumoto, Japan. Hypertension

Hypertension, Ahead of Print. This review highlights recent insights into the epigenetic mechanism of salt-sensitive hypertension from the fetus to the elderly population, mainly focusing on the DNA methylation and histone modification-mediated regulation of hypertension-associated genes. (...) (Hypertension)
11:01
Association of Pressure Wave Reflections With Left Ventricular Mass: a Systematic Review and Meta-Analysis - Lazaros K. Yofoglu Fotios Karachalias Marios K. Georgakis Christos Tountas Antonios A. Argyris Yi Zhang Theodoros G. Papaioannou Jacques Blacher Thomas Weber Charalampos Vlachopoulos Athanase D. Protogerou Cardiovascular Prevention and Research Unit, Clinic/Laboratory of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Greece (L.K.Y., F.K., C.T., A.A.A., A.D.P.). Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany (M.K.G.). Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Pressure wave reflections (PWRs) within the circulation are assessed at various arterial sites by various noninvasive methods. We aimed at reviewing the conflicting data regarding the hypothesis that higher PWRs are associated with higher left (...) (Hypertension)
11:00
Systolic Blood Pressure and Cardiovascular Risk in Patients With Diabetes: A Prospective Cohort Study - Shishir Rao Yikuan Li Milad Nazarzadeh Dexter Canoy Mohammad Mamouei Abdelaali Hassaine Gholamreza Salimi-Khorshidi Kazem Rahimi Deep Medicine, Oxford Martin School, University of Oxford, United Kingdom (S.R., Y.L., M.N., M.M., G.S.-K., K.R.). Nuffield Department of Women’s and Reproductive Health, University of Oxford, United Kingdom (S.R., Y.L., M.N., M.M., G.S.-K., K.R.). NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, United Kingdom (K.R.). Population Health Sciences Institute, University of Newcastle, United Kingdom (D.C.). Division of (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Whether the association between systolic blood pressure (SBP) and risk of cardiovascular disease is monotonic or whether there is a nadir of optimal blood pressure remains controversial. We investigated the association between SBP and cardiovascular (...) (Hypertension)

15 December

Hypertension https://www.ahajournals.org/

11:01
Elevated Placental microRNA-155 Is a Biomarker of a Preeclamptic Subtype - Zhiyin Wang Dan Liu Yimin Dai Ruotian Li Yaowu Zheng Guangfeng Zhao Jingmei Wang Zhenyu Diao Chenrui Cao Haining Lv Ning Gu Hang Zhou Hailin Ding Jie Li Xiangyu Zhu Honglei Duan Li Shen Qun Zhang Jing Chen Huilian Hu Xiaoyan Wang Mingming Zheng Yan Zhou Yali Hu From the Center for Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, China (Z.W., D.L., Y.D., G.Z., Z.D., C.C., H.L., N.G., H.Z., H.D., J.L., X.Z., H.D., L.S., Q.Z., J.C., H.H., M.Z., Y.H.) Department of Cardiology, Nanjing Drum Tower Hospital, Nanjing University Medical School, China (...) Hypertension

Hypertension, Volume 80, Issue 2, Page 370-384, February 1, 2023. Background:Preeclampsia is a complicated syndrome with marked heterogeneity. The biomarker-based classification for this syndrome is more constructive to the targeted prevention and treatment of preeclampsia. It has been reported (...) (Hypertension)
11:01
Divergent Roles of Ephrin-B2/EphB4 Guidance System in Pulmonary Hypertension - Slaven Crnkovic Sonja Rittchen Katharina Jandl Juergen Gindlhuber Diana Zabini Ayse Ceren Mutgan Francesco Valzano Panja M. Boehm Konrad Hoetzenecker Wolfgang Toller Christine Veith Akos Heinemann Ralph T. Schermuly Andrea Olschewski Leigh M. Marsh Grazyna Kwapiszewska Otto Loewi Research Center, Division of Physiology, Medical University of Graz, Austria (S.C., D.Z., A.C.M., L.M.M., G.K.). Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Austria (S.R., K.J., A.H.). Otto Loewi Research Center, Division of Immunology, Medical University of Graz, Austria (...) Hypertension

Hypertension, Volume 80, Issue 2, Page e17-e28, February 1, 2023. Background:Smooth muscle cell (SMC) expansion is one key morphological hallmark of pathologically altered vasculature and a characteristic feature of pulmonary vascular remodeling in pulmonary hypertension. Normal embryonal (...) (Hypertension)
11:00
Atrial Fibrillation Detection and Management in Hypertension - Monika Gawa?ko Dominik Linz From the 1st Department of Cardiology, Medical University of Warsaw, Poland (M.G.) Department of Cardiology, Maastricht University Medical Centre and Cardiovascular Research Institute Maastricht, Maastricht University, the Netherlands (M.G., D.L.) Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, Centre for Heart Rhythm Disorders, Royal Adelaide Hospital, University of Adelaide, Australia, and Department of Cardiology, Radboud University Medical Centre, Nijmegen, the Netherlands (...) Hypertension

Hypertension, Ahead of Print. Hypertension is prevalent in >70% of atrial fibrillation patients. In turn, hypertensive patients have up to 73% greater likelihood of atrial fibrillation. Current guidelines recommend that a systematic atrial fibrillation screening may be justified in all patients (...) (Hypertension)
11:00
Antihypertensive Medication Regimens Used in the Systolic Blood Pressure Intervention Trial - Catherine G. Derington Adam P. Bress Andrew E. Moran William S. Weintraub Jennifer S. Herrick William C. Cushman Ian M. Kronish Barry Stults Daichi Shimbo Paul Muntner Tom Greene Jeffrey T. Bates Tara I. Chang Lois Anne Katz Shakaib U. Rehman Christianne L. Roumie Leonardo Tamariz Jordan B. King University of Utah, Salt Lake City (C.G.D., A.P.B., J.S.H., B.S., T.G., J.B.K.). Columbia University Irving Medical Center, New York, NY (A.E.M., I.M.K., D.S.). MedStar Health Research Institute, Georgetown University, Washington, DC (W.S.W.). University of Tennessee Health Science Center, (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Describing the antihypertensive medication regimens used in the SPRINT (Systolic Blood Pressure Intervention Trial) would contextualize the standard and intensive systolic blood pressure (SBP) interventions and may inform future implementation efforts to (...) (Hypertension)

13 December

Hypertension https://www.ahajournals.org/

11:00
Association of Lp(a) (Lipoprotein[a]) and Hypertension in Primary Prevention of Cardiovascular Disease: The MESA - Rishi Rikhi Harpreet S. Bhatia Christopher L. Schaich Nicklaus Ashburn Michael Y. Tsai Erin D. Michos Parag A. Chevli David M. Herrington Sotirios Tsimikas Michael D. Shapiro Center for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine, Department of Internal Medicine (R.R., N.A., D.M.H., M.D.S.), Wake Forest University School of Medicine, Winston-Salem, NC. Department of Surgery, Hypertension, and Vascular Research Center (C.L.S.), Wake Forest University School of Medicine, Winston-Salem, NC. Department of Emergency Medicine (N.A.), Wake Forest University School of (...) Hypertension

Hypertension, Volume 80, Issue 2, Page 352-360, February 1, 2023. Background:This study explored the longitudinal relationship of Lp(a) (lipoprotein[a]) and hypertension to cardiovascular outcomes in a large multiethnic cohort free of baseline cardiovascular disease.Methods:Individuals from the (...) (Hypertension)

7 December

Hypertension https://www.ahajournals.org/

11:00
Hypertension and an Incidental Neck Mass in a 20-Year-Old Woman - Lisa Dubrofsky Paula J. Harvey Division of Nephrology, Department of Medicine, Women’s College Hospital and Sunnybrook Health Sciences Centre, Department of Medicine, University of Toronto, Ontario, Canada (L.D.). Division of Cardiology, Department of Medicine, University of Toronto and Women’s College Hospital, Women’s College Research Institute, Women’s College Hospital, Ontario, Canada (P.J.H.). Hypertension

Hypertension, Volume 80, Issue 2, Page 227-230, February 1, 2023. (Hypertension)
08:00
Correction to: Ten-Second Heart Rate Variability, Its Changes Over Time, and the Development of Hypertension Hypertension

Hypertension, Volume 80, Issue 1, Page e4-e4, January 1, 2023. (Hypertension)
08:00
Hypertension Impacts Peripheral Blood Leukocyte Composition - Lucas A. Salas Karl T. Kelsey Department of Epidemiology, Geisel School of Medicine at Dartmouth, Dartmouth Cancer Center, Lebanon, NH (L.A.S.). Department of Epidemiology and Pathology and Laboratory Medicine, Brown University, Providence, RI (K.T.K.). Hypertension

Hypertension, Volume 80, Issue 1, Page 54-56, January 1, 2023. (Hypertension)
08:00
In Memoriam: Fernando Elijovich - Lale A. Ertuglu Cheryl L. Laffer Annet Kirabo Division of Nephrology, Department of Medicine (L.A.E.), Vanderbilt University Medical Center, Nashville, TN. Division of Clinical Pharmacology, Department of Medicine (C.L.L., A.K.), Vanderbilt University Medical Center, Nashville, TN. Hypertension

Hypertension, Volume 80, Issue 1, Page e1-e3, January 1, 2023. (Hypertension)

6 December

Hypertension https://www.ahajournals.org/

11:00
Bromocriptine Improves Central Aortic Stiffness in Adolescents With Type 1 Diabetes: Arterial Health Results From the BCQR-T1D Study - Michal Schäfer Lorna P. Browne Uyen Truong Petter Bjornstad Shoshana Tell Janet Snell-Bergeon Amy Baumgartner Kendall S. Hunter Jane E.B. Reusch Alex J. Barker Kristen J. Nadeau Irene E. Schauer Division of Pediatric Cardiology, Department of Pediatrics (M.S.), University of Colorado – School of Medicine, Aurora. Department of Radiology (L.P.B., A.J.B.), University of Colorado – School of Medicine, Aurora. Section of Pediatric Endocrinology, Department of Pediatrics (P.B., S.T., A.B., K.J.N.), University of Colorado – School of Medicine, Aurora. Barbara Davis Center, Department of Medicine (...) Hypertension

Hypertension, Volume 80, Issue 2, Page 482-491, February 1, 2023. Background:The presence of vascular dysfunction is a well-recognized feature in youth with type 1 diabetes (T1D), accentuating their lifetime risk of cardiovascular events. Therapeutic strategies to mitigate vascular dysfunction (...) (Hypertension)

5 December

Hypertension https://www.ahajournals.org/

11:00
Clinical Utility of Short-Term Blood Pressure Measures to Inform Long-Term Blood Pressure Management - Nelson Wang Katie Harris Mark Woodward Stephen Harrap Giuseppe Mancia Neil Pouter John Chalmers Anthony Rodgers The George Institute for Global Health UNSW, Sydney, Australia (N.W., K.H., M.W., J.C., A.R.). Royal Prince Alfred Hospital, Sydney, Australia (N.W.). Sydney Medical School, University of Sydney, Australia (N.W.). School of Public Health, Imperial College London, United Kingdom (N.P.). Royal Melbourne Hospital, University of Melbourne, Victoria, Australia (S.H.). University of Milano-Bicocca, Italy (...) Hypertension

Hypertension, Ahead of Print. Background:Treatment about hypertension management are substantially influenced by blood pressure (BP) levels measured before and soon after starting BP lowering drugs. We aimed to assess the utility of short-term BP changes in individuals in terms of long-term (...) (Hypertension)

2 December

Hypertension https://www.ahajournals.org/

11:00
TSPAN12 (Tetraspanin 12) Is a Novel Negative Regulator of Aldosterone Production in Adrenal Physiology and Aldosterone-Producing Adenomas - Siyuan Gong Martina Tetti Elisabeth Kemter Mirko Peitzsch Paolo Mulatero Martin Bidlingmaier Graeme Eisenhofer Eckhard Wolf Martin Reincke Tracy Ann Williams Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Germany (S.G., M.T., M.B., M.R., T.A.W.). Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Italy (M.T., P.M., T.A.W.). Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, Ludwig-Maximilians-Universität München, Munich, Germany (E.K., E.W.). Institute (...) Hypertension

Hypertension, Volume 80, Issue 2, Page 440-450, February 1, 2023. Background:Aldosterone-producing adenomas (APAs) are a major cause of primary aldosteronism, a condition of low-renin hypertension, in which aldosterone overproduction is usually driven by a somatic activating mutation in an ion (...) (Hypertension)
11:00
Intracranial Carotid Arteriosclerosis Mediates the Association Between Blood Pressure and Cerebral Small Vessel Disease - Jesus D. Melgarejo Meike W. Vernooij M. Arfan Ikram Zhen-Yu Zhang Daniel Bos Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (J.D.M., Z.-Y.Z., D.B.). Laboratory of Neurosciences, Faculty of Medicine, University of Zulia, Maracaibo, Venezuela (J.D.M.). Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands (M.W.V., M.A.I., D.B.). Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, the Netherlands (M.W.V., (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Intracranial arteriosclerosis could explain the association between blood pressure (BP) and cerebral small vessel disease (CSVD). Therefore, we tested whether intracranial carotid artery calcification (ICAC) mediates the association between BP and CSVD (...) (Hypertension)
11:00
The Microsoft Research Aurora Project: Important Findings on Cuffless Blood Pressure Measurement - Ramakrishna Mukkamala Sanjeev G. Shroff Cederick Landry Konstantinos G. Kyriakoulis Alberto P. Avolio George S. Stergiou Department of Bioengineering, University of Pittsburgh, PA (R.M., S.G.S., C.L.). Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, PA (R.M.). Hypertension Center STRIDE-7, School of Medicine, Third Department of Medicine, Sotiria Hospital, National and Kapodistrian University of Athens, Athens, Greece (K.G.K., G.S.S.). Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia (...) Hypertension

Hypertension, Ahead of Print. Conventional blood pressure (BP) measurement devices based on an inflatable cuff only provide a narrow view of the continuous BP profile. Cuffless BP measuring technologies could permit numerous BP readings throughout daily life and thereby considerably improve the (...) (Hypertension)

30 November

Hypertension https://www.ahajournals.org/

11:00
MicroRNA-195a-5p Regulates Blood Pressure by Inhibiting NKCC2A - Shoujin Hao Hong Zhao David H. Hao Nicholas R. Ferreri Department of Pharmacology, New York Medical College, Valhalla. Hypertension

Hypertension, Volume 80, Issue 2, Page 426-439, February 1, 2023. Background:Previous studies showed that miR-195a-5p was among the most abundant microRNAs (miRNAs) expressed in the kidney.Methods:Lentivirus silencing of tumor necrosis factor-? (TNF) was performed in vivo and in vitro. (...) (Hypertension)
11:00
Amount of Pannexin 1 in Smooth Muscle Cells Regulates Sympathetic Nerve–Induced Vasoconstriction - Luke S. Dunaway Marie Billaud Edgar Macal Miranda E. Good Christopher B. Medina Ulrike Lorenz Kodi Ravichandran Michael Koval Brant E. Isakson Robert M. Berne Cardiovascular Research Center (L.S.D., E.M., B.E.I.), University of Virginia School of Medicine, Charlottesville. Center for Cell Clearance (C.B.M.), University of Virginia School of Medicine, Charlottesville. Department of Microbiology, Immunology and Cancer Biology (C.B.M., U.L.), University of Virginia School of Medicine, Charlottesville. Carter Immunology Center (U.L., K.R.), University of Virginia School of Medicine, (...) Hypertension

Hypertension, Volume 80, Issue 2, Page 416-425, February 1, 2023. Background:Panx1 (pannexin 1) forms high conductance channels that secrete ATP upon stimulation. The role of Panx1 in mediating constriction in response to direct sympathetic nerve stimulation is not known. Additionally, it is (...) (Hypertension)
11:00
Detrimental Role of PDZ-RhoGEF in Pathological Cardiac Hypertrophy - Jia Huang Qingrong Qu Yuxiang Dai Daoyuan Ren Juying Qian Junbo Ge Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China and National Clinical Research Center for Interventional Medicine (J.H., Y.D., D.R., J.Q., J.G.). Department of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China and Shanghai Clinical Research Center for Tuberculosis, Shanghai, China (...) Hypertension

Hypertension, Volume 80, Issue 2, Page 403-415, February 1, 2023. Background:Postsynaptic density 95/disk-large/ZO-1 Rho guanine nucleotide exchange factor (PDZ-RhoGEF, PRG) functions as a RhoGEF for activated G?13 and transmits activation signals to downstream signaling pathways in various (...) (Hypertension)
11:00
Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report - Michelle L. Gumz Daichi Shimbo Marwah Abdalla Ravi C. Balijepalli Christian Benedict Yabing Chen David J. Earnest Karen L. Gamble Scott R. Garrison Ming C. Gong John B. Hogenesch Yuling Hong Jessica R. Ivy Bina Joe Aaron D. Laposky Mingyu Liang Eric J. MacLaughlin Tami A. Martino David M. Pollock Susan Redline Amy Rogers R. Dan Rudic Eva S. Schernhammer George S. Stergiou Marie-Pierre St-Onge Xiaoling Wang Jacqueline Wright Young S. Oh Department of Physiology and Aging; Center for Integrative Cardiovascular and Metabolic Disease, Department of Medicine, Division of Nephrology, (...) Hypertension

Hypertension, Ahead of Print. Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood pressure during wakefulness and lower blood pressure during sleep. Loss or disruption of the blood pressure circadian rhythm has been linked to adverse health outcomes, for (...) (Hypertension)

28 November

Hypertension https://www.ahajournals.org/

11:00
Distinct Mechanisms of ?-Arrestin–Biased Agonist and Blocker of AT1R in Preventing Aortic Aneurysm and Associated Mortality - Zaira Palomino Jara Terri J. Harford Khuraijam Dhanachandra Singh Russell Desnoyer Avinash Kumar Dasarathy Srinivasan Sadashiva S. Karnik Cardiovascular and Metabolic Sciences Department, Lerner Research Institute, Cleveland Clinic‚ Cleveland‚ OH (Z.P.J., T.J.H., K.D.S., R.D., S.S.K.). Pathobiology Department‚ Lerner Research Institute‚ Cleveland Clinic‚ Cleveland‚ OH (D.S.‚ A.K.). Hypertension

Hypertension, Volume 80, Issue 2, Page 385-402, February 1, 2023. Background:Aortic aneurysm (AA) is a “silent killer” human disease with no effective treatment. Although the therapeutic potential of various pharmacological agents have been evaluated, there are no reports of ?-arrestin–biased AT1R (...) (Hypertension)

23 November

Hypertension https://www.ahajournals.org/

11:00
Sympathetic Neural Overdrive, Aortic Stiffening, Endothelial Dysfunction, and Impaired Exercise Capacity in Severe COVID-19 Survivors: A Mid-Term Study of Cardiovascular Sequelae - Diego Faria Renata J. Moll-Bernardes Laura Testa Camila M.V. Moniz Erika C. Rodrigues Amanda G. Rodrigues Amanda Araujo Maria J.N.N. Alves Bruna E. Ono João E. Izaias Vera M.C. Salemi Camila P. Jordão Graziela Amaro-Vicente Maria U.P.B. Rondon Katelyn R. Ludwig Daniel H. Craighead Matthew J. Rossman Fernanda M. Consolim-Colombo Katia De Angelis Maria C.C. Irigoyen Douglas R. Seals Carlos E. Negrão Allan R.K. Sales D’Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil (D.F., R.J.M.-B., E.C.R., B.E.O., J.E.I., A.R.K.S.). D’Or Institute for Research and Education (IDOR), São (...) Hypertension

Hypertension, Volume 80, Issue 2, Page 470-481, February 1, 2023. Background:COVID-19 has become a dramatic health problem during this century. In addition to high mortality rate, COVID-19 survivors are at increased risk for cardiovascular diseases 1-year after infection. Explanations for these (...) (Hypertension)

21 November

Hypertension https://www.ahajournals.org/

11:00
Relation of Pulse Wave Velocity to Contemporaneous and Historical Blood Pressure in Female Twins - Louise Keehn Massimo Mangino Tim Spector Phil Chowienczyk Marina Cecelja Department of Clinical Pharmacology, King’s College London British Heart Foundation Centre, St Thomas’ Hospital (L.K., P.C., M.C.). NIHR Biomedical Research Centre at Guy’s and St Thomas’ Foundation Trust, London (M.M.). Department of Twin Research and Genetic Epidemiology, King’s College London, St Thomas Hospital (M.M., T.S.). Hypertension

Hypertension, Volume 80, Issue 2, Page 361-369, February 1, 2023. Background:An association between blood pressure and aortic stiffness is well known, but ambiguity remains as to whether one precedes the other. This study aimed to investigate the association of aortic stiffness with (...) (Hypertension)

18 November

Hypertension https://www.ahajournals.org/

11:00
Combination Immune Checkpoint Inhibitor Therapy is Associated With Increased Blood Pressure in Melanoma Patients - Isik Turker Ananya Sharma Shi Huang Douglas B. Johnson Matthew R. Alexander Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center (VUMC), Nashville, TN (I.T., M.R.A.). Department of Medicine, Division of Cardiology, Washington University School of Medicine, St Louis, MO (I.T.). Vanderbilt University School of Medicine, Nashville, TN (A.S.). Department of Biostatistics, Vanderbilt University, Nashville, TN (S.H.). Department of Medicine, Division of Hematology and Oncology, VUMC, Nashville, TN (D.B.J.). Department of Medicine, Division of (...) Hypertension

Hypertension, Ahead of Print. (Hypertension)

17 November

Hypertension https://www.ahajournals.org/

11:00
Glycoprotein Serum Concentrations Assessed By 1H-NMR are Increased in Patients With High Blood Pressure - Natalia Andreychuk Dídac Llop Juan Moreno-Vedia Josefa Girona Daiana Ibarretxe Cèlia Rodríguez-Borjabad Núria Plana Lluís Masana Unitat de Medicina Vascular i Metabolisme (UVASMET), Unitat de Recerca en Lípids i Arteriosclerosis, Hospital Universitari Sant Joan, Universitat Rovira i Virgili, CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, IISPV, Reus, Spain. Hypertension

Hypertension, Volume 80, Issue 2, Page 460-469, February 1, 2023. Background:Patients with hypertension present a permanent state of low-grade inflammation, as the disease activates several pro-inflammatory cells and inflammatory pathways. Glycoproteins A, B, and F, determined by proton nuclear (...) (Hypertension)
11:00
Association of Home and Ambulatory Blood Pressure With Cardiovascular Prognosis in Practice Hypertensive Outpatients - Keisuke Narita Satoshi Hoshide Kazuomi Kario Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan. Hypertension

Hypertension, Volume 80, Issue 2, Page 451-459, February 1, 2023. Background:Although international guidelines for hypertension management recommend home and ambulatory blood pressure (BP) monitoring, few studies have assessed which is more useful in predicting cardiovascular incidence in (...) (Hypertension)

15 November

Hypertension https://www.ahajournals.org/

11:00
De Novo Postpartum Hypertension: Incidence and Risk Factors at a Safety-Net Hospital - Samantha E. Parker Ayodele Ajayi Christina D. Yarrington Department of Epidemiology, Boston University School of Public Health, MA (S.E.P., A.A.). Department of Obstetrics and Gynecology, Boston University School of Medicine, MA (C.D.Y.). Hypertension

Hypertension, Volume 80, Issue 2, Page 279-287, February 1, 2023. Background:Postpartum hypertension can be persistent, following a pregnancy complicated by hypertension, or new onset (de novo), following a normotensive pregnancy. The aim of this study is to estimate the incidence and identify (...) (Hypertension)
11:00
Integrin CD11b Contributes to Hypertension and Vascular Dysfunction Through Mediating Macrophage Adhesion and Migration - Qiu-Yue Lin Jie Bai Yun-Long Zhang Hui-Hua Li Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, China (Q.-Y.L., J.B., H.-H.L.). Department of Emergency Medicine, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China (Y.-L.Z., H.-H.L.). Hypertension

Hypertension, Volume 80, Issue 1, Page 57-69, January 1, 2023. Background:Leukocyte adhesion to endothelium is an early inflammatory response and is mainly controlled by the ?2-integrins. However, the role of integrin CD11b/CD18 in the pathogenesis of hypertension and vascular dysfunction is (...) (Hypertension)

11 November

Hypertension https://www.ahajournals.org/

11:00
TSG-6 (Tumor Necrosis Factor-?-Stimulated Gene/Protein-6): An Emerging Remedy for Renal Inflammation - Yamei Jiang Logan M. Glasstetter Amir Lerman Lilach O. Lerman Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (Y.J., L.M.G., L.O.L.). Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (A.L.). Hypertension

Hypertension, Volume 80, Issue 1, Page 35-42, January 1, 2023. The inflammatory response is a major pathological feature in most kidney diseases and often evokes compensatory mechanisms. Recent evidence suggests that TSG-6 (tumor necrosis factor-?-stimulated gene/protein-6) plays a pivotal role (...) (Hypertension)

10 November

Hypertension https://www.ahajournals.org/

11:01
Retraction of: Abstract P124: Bainiku-ekisu Attenuates Cardiac Remodeling in Angiotensin Ii-infused Mice Hypertension

Hypertension, Volume 80, Issue 1, Page e5-e5, January 1, 2023. (Hypertension)
11:00
Independent Associations of Education, Intelligence, and Cognition With Hypertension and the Mediating Effects of Cardiometabolic Risk Factors: A Mendelian Randomization Study - Yiying Wang Chaojie Ye Lijie Kong Jie Zheng Min Xu Yu Xu Mian Li Zhiyun Zhao Jieli Lu Yuhong Chen Weiqing Wang Guang Ning Yufang Bi Tiange Wang Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China (Y.W., C.Y., L.K., J.Z., M.X., Y.X., M.L., Z.Z., J.L., Y.C., W.W., G.N., Y.B., T.W.). Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key (...) Hypertension

Hypertension, Volume 80, Issue 1, Page 192-203, January 1, 2023. Background:Education, intelligence, and cognition are associated with hypertension, but which one plays the most prominent role in the pathogenesis of hypertension and which modifiable risk factors mediate the causal effects (...) (Hypertension)
11:01
Respiratory Microbiome Profile of Pediatric Pulmonary Hypertension Patients Associated With Congenital Heart Disease - Ting Wang Yue Xing Bingming Peng Kai Yang Chenting Zhang Yuqin Chen Gang Geng Qubei Li Jian Fu Mi Li Zhengxiu Luo Zhou Fu Jian Wang Department of Respiratory Children’s Hospital of Chongqing Medical University (T.W., B.P., G.G., Q.L., Z.L., Z.F.), National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children’s Hospital of Chongqing Medical University, China. Department of thoracic and Cardiac Surgery Children’s Hospital of Chongqing Medical University (J.F.), National Clinical Research Center for Child (...) Hypertension

Hypertension, Volume 80, Issue 1, Page 214-226, January 1, 2023. Background:Pulmonary hypertension (PH) associated with congenital heart disease (CHD) is the most common type of PH in pediatric patients. The airway microbiome profile in CHD-PH patients remains rarely studied.Methods:A total of (...) (Hypertension)
11:01
Effect of Immediate Antihypertensive Treatment on Clinical Outcomes in Acute Ischemic Stroke Patients With Different Renal Function Status - Yujia Zhai Bizhong Che Yang Liu Hao Peng Aili Wang Yanbo Peng Jing Chen Yonghong Zhang Tan Xu Chongke Zhong Jiang He Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Suzhou Medical College of Soochow University, China (Y.Z., B.C., H.P., A.W., Y.Z., T.X., C.Z.). Department of Cardiology, First Affiliated Hospital of Soochow University, Suzhou, China (Y.L.). Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (Y.L., J.C., C.Z., J.H.). (...) Hypertension

Hypertension, Volume 80, Issue 1, Page 204-213, January 1, 2023. Background:It remains unclear whether different blood pressure management strategies should be administered for acute stroke patients with or without impaired renal function. We conducted a secondary analysis of the CATIS trial (...) (Hypertension)

8 November

Hypertension https://www.ahajournals.org/

11:01
Association Between Hypertensive Disorders of Pregnancy and Dementia: a Systematic Review and Meta-Analysis - Karen C. Schliep Hailey Mclean Bin Yan Fares Qeadan Lauren H. Theilen Adam de Havenon Jennifer J. Majersik Truls Østbye Surendra Sharma Michael W. Varner Department of Family and Preventative Medicine (K.C.S., H.M., B.Y.), University of Utah, Salt Lake City. Department of Obstetrics and Gynecology (L.H.T., M.W.V.), University of Utah, Salt Lake City. Department of Neurology (J.J.M.), University of Utah, Salt Lake City. Department of Public Health Sciences, Loyola University Chicago, IL (F.Q.). Department of Neurology, Yale University, New Haven, CT (A.d.H.). Community and Family Medicine, (...) Hypertension

Hypertension, Volume 80, Issue 2, Page 257-267, February 1, 2023. Background:Prior meta-analyses report a 2- to 4-fold increased risk of later cardiovascular disease among women with a history of hypertensive disorders of pregnancy (HDP). Given HDP’s vascular underpinnings, it is hypothesized to (...) (Hypertension)
11:01
Association Between DNA Methylation and Blood Pressure: A 5-Year Longitudinal Twin Study - Xuanming Hong Ke Miao Weihua Cao Jun Lv Canqing Yu Tao Huang Dianjianyi Sun Chunxiao Liao Yuanjie Pang Zengchang Pang Min Yu Hua Wang Xianping Wu Yu Liu Wenjing Gao Liming Li Department of Epidemiology and Biostatistics, School of Public Health, Peking University, China (X.H., K.M., W.C., J.L., C.Y., T.H., D.S., C.L., Y.P., W.G., L.L.). Qingdao Center for Disease Control and Prevention, China (Z.P.). Zhejiang Center for Disease Control and Prevention, Hangzhou, China (M.Y.). Jiangsu Center for Disease Control and Prevention, Nanjing, China (H.W.). Sichuan Center for Disease Control and (...) Hypertension

Hypertension, Volume 80, Issue 1, Page 169-181, January 1, 2023. Background:Previous EWASs (Epigenome-Wide Association Studies) have reported hundreds of blood pressure (BP) associated 5?-cytosine-phosphate-guanine-3? (CpG) sites. However, their results were inconsistent. Longitudinal (...) (Hypertension)
11:00
The Novel Lysosomal Autophagy Inhibitor (ROC-325) Ameliorates Experimental Pulmonary Hypertension - Changlei Bao Shuxin Liang Ying Han Zi Yang Shiyun Liu Yanan Sun Shichuang Zheng Yuzhu Li Ting Wang Yali Gu Kang Wu Stephen M. Black Jian Wang Steffan T. Nawrocki Jennifer S. Carew Jason X.-J. Yuan Haiyang Tang State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, China (C.B., S.L., Z.Y., S.L., Y.S., S.Z., Y.L., K.W., J.W., H.T.). College of Veterinary Medicine, Northwest A&F University, (...) Hypertension

Hypertension, Volume 80, Issue 1, Page 70-83, January 1, 2023. Background:Autophagy plays an important role in the pathogenesis of pulmonary hypertension (PH). ROC-325 is a novel small molecule lysosomal autophagy inhibitor that has more potent anticancer activity than the antimalarial drug (...) (Hypertension)

7 November

Hypertension https://www.ahajournals.org/

10:00
Mechanism by Which Inflammation and Oxidative Stress Induce Mineralocorticoid Receptor Gene Expression in Aging Vascular Smooth Muscle Cells - Jaime Ibarrola Qing Lu Maria-Christina Zennaro Iris Z. Jaffe Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA (J.I., Q.L., I.Z.J.). Université de Paris, INSERM, PARCC, Paris, France (M.-C.Z.) Hypertension

Hypertension, Volume 80, Issue 1, Page 111-124, January 1, 2023. Background:Vascular MR (mineralocorticoid receptor) expression increases with age driving aging-associated vascular stiffness and hypertension. MR has two isoforms (1? and 1?) with distinct 5?-untranslated and promoter sequences (P1 (...) (Hypertension)
10:00
Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin II-Induced Hypertension - Lucia S. Díaz del Campo Ana B. García-Redondo Cristina Rodríguez Carlos Zaragoza Santiago Duro-Sánchez Francesco Palmas Angela de Benito-Bueno Paula G. Socuéllamos Diego A. Peraza Raquel Rodrigues-Díez Carmen Valenzuela Jesmond Dalli Mercedes Salaices Ana M. Briones Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain (L.S.D.d.C., A.B.G.-R., S.D.-S, R.R.-D., M.S., A.M.B.). Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain (A.B.G.-R.). Instituto de Investigación Sanitaria del Hospital Universitario La Paz (...) Hypertension

Hypertension, Volume 80, Issue 1, Page 84-96, January 1, 2023. Background:Resolution of inflammation is orchestrated by specialized proresolving lipid mediators (SPMs), and this would be impaired in some cardiovascular diseases. Among SPMs, resolvins (Rv) have beneficial effects in (...) (Hypertension)

4 November

Hypertension https://www.ahajournals.org/

10:01
The Assembled Genome of the Stroke-Prone Spontaneously Hypertensive Rat - Theodore S. Kalbfleisch Nahla A. Hussien AbouEl Ela Kai Li Wesley A. Brashear Kelli J. Kochan Andrew E. Hillhouse Yaming Zhu Isha S. Dhande Eric J. Kline Elizabeth A. Hudson Terence D. Murphy Françoise Thibaud-Nissen Melissa L. Smith Peter A. Doris Department of Veterinary Science, College of Agriculture, Food, and Environment, University of Kentucky, Lexington, KY (T.S.K., N.A.H., K.L.). Texas A&M Institute for Genome Sciences and Society, Texas A&M University, College Station, TX (W.A.B., K.J.K., A.E.H.). Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, (...) Hypertension

Hypertension, Volume 80, Issue 1, Page 138-146, January 1, 2023. Background:We report the creation and evaluation of a de novo assembly of the genome of the spontaneously hypertensive rat, the most widely used model of human cardiovascular disease.Methods:The genome is assembled from long read (...) (Hypertension)
10:01
11S Proteasome Activator REG? Promotes Aortic Dissection by Inhibiting RBM3 (RNA Binding Motif Protein 3) Pathway - Yifan Xie Rifeng Gao Yang Gao Zheng Dong Junbo Ge Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China (Y.X., R.G., Y.G., Z.D., J.G.). Shanghai Institute of Cardiovascular Diseases‚ Shanghai‚ China (Y.X., R.G., Y.G., Z.D., J.G.). Institutes of Biomedical Science, Fudan University, Shanghai, China (Y.X., J.G.). Hypertension

Hypertension, Volume 80, Issue 1, Page 125-137, January 1, 2023. Background:Aortic dissection (AD) is a life-threatening cardiovascular disorder with high mortality and lacking underlying mechanisms or effective treatments. REG?, the 11S proteasome activator known to promote the degradation of (...) (Hypertension)
10:01
Antihypertensive Medication Adherence and the Risk of Vascular Events and Falls After Stroke: A Real-World Effectiveness Study Using Linked Registry Data - Lachlan L. Dalli Muideen T. Olaiya Joosup Kim Nadine E. Andrew Dominique A. Cadilhac David Ung Richard I. Lindley Frank M. Sanfilippo Amanda G. Thrift Mark R. Nelson Seana L. Gall Monique F. Kilkenny Stroke and Ageing Research, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia (L.L.D., M.T.O., J.K., D.A.C., A.G.T., S.L.G., M.F.K.). The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Heidelberg, VIC, Australia (J.K., D.A.C., M.F.K.). Peninsula Clinical School, Central Clinical School, Monash (...) Hypertension

Hypertension, Volume 80, Issue 1, Page 182-191, January 1, 2023. Background:Real-world evidence is limited on whether antihypertensive medications help avert major adverse cardiovascular events (MACE) after stroke without increasing the risk of falls. We investigated the association of (...) (Hypertension)
10:00
Loss of ADAM15 Exacerbates Transition to Decompensated Myocardial Hypertrophy and Dilation Through Activation of the Calcineurin Pathway - Preetinder K. Aujla Mei Hu Bridgette Hartley Joshua W. Kranrod Anissa Viveiros Tolga Kilic Caroline A. Owen Gavin Y. Oudit John M. Seubert Olivier Julien Zamaneh Kassiri Department of Physiology, Cardiovascular Research Center, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada (P.K.A., M.H., A.V., T.K., G.Y.O., Z.K.). Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada (B.H., O.J.). Department of Pharmacology, Faculty of Medicine and Dentistry; Faculty of Pharmacy and Pharmaceutical Sciences, University of (...) Hypertension

Hypertension, Volume 80, Issue 1, Page 97-110, January 1, 2023. Background:Myocardial hypertrophy and dilation are key features of cardiomyopathies and involve several cellular and molecular events. ADAMs (a disintegrin and metalloproteinases) are membrane-bound proteinases with diverse (...) (Hypertension)
10:00
Attenuated Relationships Between Indexes of Volume Overload and Atrial Natriuretic Peptide in Uncontrolled, Sustained Volume-Dependent Primary Hypertension - Suraj M. Yusuf Gavin R. Norton Vernice R. Peterson Nico Malan Monica Gomes Nonhlanhla Mthembu Carlos D. Libhaber Grace Tade Hamza Bello Adamu J. Bamaiyi Keneilwe N. Mmopi Ferande Peters Pinhas Sareli Patrick H. Dessein Angela J. Woodiwiss Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Hypertension

Hypertension, Volume 80, Issue 1, Page 147-159, January 1, 2023. Background:Whether systolic blood pressure (SBP) control in sustained volume-dependent primary hypertension is associated with blunted ANP (atrial natriuretic peptide) relationships with indexes of volume load is (...) (Hypertension)

31 October

Hypertension https://www.ahajournals.org/

10:00
Long-Term Adiposity and Midlife Carotid Intima-Media Thickness Are Linked Partly Through Intermediate Risk Factors - Tao Zhang Bingbing Fan Shengxu Li Xuan Wang Yawei Kong Lydia Bazzano Jiang He Wei Chen Yinkun Yan Department of Biostatistics, School of Public Health, Cheeloo College of Medicine (T.Z., B.F.). National Institute of Health Data Science (T.Z., B.F.), Shandong University, Jinan, China. Children’s Minnesota Research Institute, Children’s Minnesota, Minneapolis (S.L.). Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans (X.W., L.B., J.H., W.C.). Center for Non-communicable Disease Management, Beijing Children’s Hospital, Capital Medical (...) Hypertension

Hypertension, Volume 80, Issue 1, Page 160-168, January 1, 2023. Objective:This study aims to determine quantitatively the mediation effects of multiple cardiovascular risk factors on the associations of childhood body mass index (BMI) and its cumulative burden with adult carotid intima-media (...) (Hypertension)

19 October

Hypertension https://www.ahajournals.org/

11:00
Peripheral Immune Cell Composition is Altered in Women Before and After a Hypertension Diagnosis - Jacob K. Kresovich Zongli Xu Katie M. O’Brien Christine G. Parks Clarice R. Weinberg Dale P. Sandler Jack A. Taylor Departments of Cancer Epidemiology and Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL (J.K.K.). Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC (J.K.K., Z.X., K.M.O., C.G.P., D.P.S., J.A.T.). Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC (C.R.W.). Epigenetic and Stem Cell Biology Laboratory, National (...) Hypertension

Hypertension, Volume 80, Issue 1, Page 43-53, January 1, 2023. Background:The development and consequences of hypertension involve multiple biological systems that may include changes in immune profiles. Whether hypertension is related to peripheral immune cell composition has not been examined (...) (Hypertension)

18 October

Hypertension https://www.ahajournals.org/

11:00
Systolic Blood Pressure Time in Target Range and Major Adverse Kidney and Cardiovascular Events - Leo F. Buckley William L. Baker Benjamin W. Van Tassell Jordana B. Cohen Omar Alkhezi Adam P. Bress Dave L. Dixon Department of Pharmacy Services, Brigham and Women’s Hospital, MA (L.F.B., O.A.). Department of Pharmacy Practice, University of Connecticut (W.L.B.). Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University (B.W.V.T., D.L.D.). Department of Medicine, University of Pennsylvania (J.B.C.). Pharmacy Practice Department, Unaizah College of Pharmacy, Qassim University, Qassim, Saudi Arabia (O.A.). University of Utah (...) Hypertension

Hypertension, Volume 80, Issue 2, Page 305-313, February 1, 2023. Background:Whether time-in-target range (TTR) for systolic blood pressure (SBP) associates with adverse kidney and cardiovascular events remains incompletely understood.Methods:This study included participants in 2 clinical (...) (Hypertension)

3 October

Hypertension https://www.ahajournals.org/

11:00
Trial of Intrapartum Extended-Release Nifedipine to Prevent Severe Hypertension Among Pregnant Individuals With Preeclampsia With Severe Features - Erin M. Cleary Nicholas W. Racchi K. Grace Patton Meghana Kudrimoti Maged M. Costantine Kara M. Rood Departments of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, The Ohio State University College of Medicine, Columbus, OH (E.M.C., K.G.P., M.M.C., K.M.R.) Ohio University Heritage College of Osteopathic Medicine, Athens, OH (N.W.R) The Ohio State University College of Medicine, Columbus, OH (M.K.) Hypertension

Hypertension, Volume 80, Issue 2, Page 335-342, February 1, 2023. Background:Preeclampsia is associated with maternal and perinatal morbidity. Besides acute therapy for severe hypertension, best practices are lacking for intrapartum hypertension management. Our objective was to test the (...) (Hypertension)

26 September

Hypertension https://www.ahajournals.org/

11:00
Risk of Hypertensive Disorders in Pregnancy After Fresh and Frozen Embryo Transfer in Assisted Reproduction: A Population-Based Cohort Study With Within-Sibship Analysis - Sindre H. Petersen Kjersti Westvik-Johari Anne Lærke Spangmose Anja Pinborg Liv Bente Romundstad Christina Bergh Bjørn Olav Åsvold Mika Gissler Aila Tiitinen Ulla-Britt Wennerholm Signe Opdahl Department of Public Health and Nursing, Faculty of Medicine and Health Sciences (S.H.P., K.W.-J., S.O.), Norwegian University of Science and Technology, Trondheim, Norway. K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences (B.O.A.), Norwegian University of Science and Technology, Trondheim, Norway. Department of Fertility, (...) Hypertension

Hypertension, Volume 80, Issue 2, Page e6-e16, February 1, 2023. Background:Frozen embryo transfer (frozen-ET) is increasingly common because of improved cryopreservation methods and elective freezing of all embryos. Frozen-ET is associated with higher risk of hypertensive disorders in (...) (Hypertension)

23 September

Hypertension https://www.ahajournals.org/

11:00
First-Trimester Normotension Is a Weak Indicator of Normal Maternal Cardiovascular Function - Wilfried Gyselaers Pauline Dreesen Anneleen Simone Staelens Kathleen Tomsin Liesbeth Bruckers Sharona Vonck UHasselt, Faculty of Medicine and Life Sciences, Diepenbeek, Belgium (W.G., P.D., A.S.S., K.T., S.V.). Department of Obstetrics and Gynaecology, Ziekenhuis Oost-Limburg, Genk, Belgium (W.G., P.D.). Department of Physiology (W.G., P.D., A.S.S., K.T., S.V.), Hasselt University, Agoralaan, Diepenbeek, Belgium. Interuniversity Institute for Biostatistics and statistical Bioinformatics (L.B.), Hasselt University, Agoralaan, Diepenbeek, (...) Hypertension

Hypertension, Volume 80, Issue 2, Page 343-351, February 1, 2023. Background:As by definition, mean arterial pressure equals the product of cardiac output (CO) and total vascular resistance (TPR), we hypothesized that, irrespective of thresholds to define hypertension, a CO-TPR imbalance might (...) (Hypertension)

21 September

Hypertension https://www.ahajournals.org/

13:46
Hypertension, Neurovascular Dysfunction, and Cognitive Impairment - Monica M. Santisteban Costantino Iadecola Daniela Carnevale Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY (M.M.S., C.I.). Department of Molecular Medicine, “Sapienza” University of Rome, Italy (D.C.). Research Unit of Neuro and Cardiovascular Pathophysiology, IRCCS Neuromed, Pozzilli, Italy (D.C.). Hypertension

Hypertension, Volume 80, Issue 1, Page 22-34, January 1, 2023. Hypertension affects a significant proportion of the adult and aging population and represents an important risk factor for vascular cognitive impairment and late-life dementia. Chronic high blood pressure continuously challenges (...) (Hypertension)

16 September

Hypertension https://www.ahajournals.org/

11:00
Trends in Blood Pressure Treatment Intensification in Older Adults With Hypertension in the United States, 2008 to 2018 - Nicholas Chiu Leonard Chiu Rahul Aggarwal Inbar Raber Deepak L. Bhatt Kenneth J. Mukamal Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (N.C., I.R., K.J.M.). Vanderbilt University Medical Center, Vanderbilt University School of Medicine, Nashville, TN (L.C.). Brigham and Women’s Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA (R.A., D.L.B.). Hypertension

Hypertension, Ahead of Print. BACKGROUND:Hypertension control has worsened nationally, and treatment intensification is important for control. National trends for appropriate blood pressure intensification for older adults are unknown. We determine the proportion of ambulatory visits where (...) (Hypertension)

9 September

Hypertension https://www.ahajournals.org/

11:00
Growing Heart Failure Burden of Hypertensive Heart Disease: A Call to Action - Javier Díez Javed Butler Center for Applied Medical Research (CIMA), and School of Medicine, Universidad de Navarra, and Center for Network Biomedical Research of Cardiovascular Diseases (CIBERCV), Carlos III Institute of Health, Madrid, Spain (J.D.). Baylor Scott and White Research Institute, Dallas, TX, and Department of Medicine, University of Mississippi School of Medicine, Jackson (J.B.). Hypertension

Hypertension, Volume 80, Issue 1, Page 13-21, January 1, 2023. Hypertensive heart disease (HHD) is currently the second leading cause of heart failure. The prevalence of HHD and its associated risk of heart failure have increased despite substantial improvement in arterial hypertension (...) (Hypertension)

7 September

Hypertension https://www.ahajournals.org/

11:00
Sensitization of Hypertension: The Impact of Earlier Life Challenges: Excellence Award for Hypertension Research 2021 - Baojian Xue Alan Kim Johnson Department of Psychological and Brain Sciences (B.X., A.K.J.), University of Iowa, Iowa City. Neuroscience and Pharmacology (A.K.J.), University of Iowa, Iowa City. Health and Human Physiology (A.K.J.), University of Iowa, Iowa City. François M. Abboud Cardiovascular Research Center (A.K.J.), University of Iowa, Iowa City. Hypertension

Hypertension, Volume 80, Issue 1, Page 1-12, January 1, 2023. Hypertension affects over 1 billion individuals worldwide. Because the cause of hypertension is known only in a small fraction of patients, most individuals with high blood pressure are diagnosed as having essential hypertension. (...) (Hypertension)

6 September

Hypertension https://www.ahajournals.org/

11:00
Sympathetic Action Potential Firing and Recruitment Patterns Are Abnormal in Gestational Hypertension - Mark B. Badrov Jeung-Ki Yoo Sarah L. Hissen David B. Nelson J. Kevin Shoemaker Qi Fu Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX (M.B.B., J.-K.Y., S.L.H., Q.F.). University of Texas Southwestern Medical Center, Dallas, TX (M.B.B., J.-K.Y., S.L.H., D.B.N., Q.F.). Department of Medicine, Toronto General Health Research Institute, University Health Network, Toronto, ON, Canada (M.B.B.). School of Kinesiology (J.K.S.), Western University, London, ON, Canada. Department of Physiology and Pharmacology (J.K.S.), Western University, (...) Hypertension

Hypertension, Volume 80, Issue 2, Page 291-301, February 1, 2023. Background:We tested the hypothesis that women who develop gestational hypertension (GH) display abnormal sympathetic action potential (AP) discharge patterns during late pregnancy (32–36 weeks), both at supine rest and during (...) (Hypertension)

23 August

Hypertension https://www.ahajournals.org/

11:00
Salt Sensitivity of Blood Pressure in Women - Candee T. Barris Jessica L. Faulkner Eric J. Belin de Chantemèle Vascular Biology Center (C.T.B., J.L.F., E.J.B.d.C.), Medical College of Georgia at Augusta University. Department of Medicine (Cardiology) (E.J.B.d.C.), Medical College of Georgia at Augusta University. Physiology Department (J.L.F.), Medical College of Georgia at Augusta University. Hypertension

Hypertension, Volume 80, Issue 2, Page 268-278, February 1, 2023. Several clinical and large population studies indicate that women are more salt-sensitive than men, yet the precise mechanisms by which the sexually dimorphic onset manifests remains incompletely understood. Here, we evaluate (...) (Hypertension)

3 August

Hypertension https://www.ahajournals.org/

11:00
Brain Vascular Dysfunction in Mothers and Their Children Exposed to Preeclampsia - Carlos Escudero Ellen Kupka Belen Ibañez Hermes Sandoval Felipe Troncoso Anna-Karin Wikström Daniela López-Espíndola Jesenia Acurio Pablo Torres-Vergara Lina Bergman Vascular Physiology Laboratory, Department of Basic Sciences, Faculty of Basic Sciences, University of Bío-Bío, Chillán, Chile (C.E., B.I., H.S., F.T., J.A.). Group of Research and Innovation in Vascular Health (GRIVAS Health), Chillán, Chile (C.E., J.A., P.T.-V.). Institute of Clinical Sciences, Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Sweden (E.K.). Department of Women’s and Children’s (...) Hypertension

Hypertension, Volume 80, Issue 2, Page 242-256, February 1, 2023. Preeclampsia is a maternal syndrome characterized by the new onset of hypertension and proteinuria after 20 weeks of gestation associated with multisystemic complications, including brain alterations. Indeed, brain complications (...) (Hypertension)

1 August

Hypertension https://www.ahajournals.org/

11:01
Sex Differences in Blood Pressure and Potential Implications for Cardiovascular Risk Management - Dean S. Picone Elif Stoneman Antoine Cremer Martin G. Schultz Petr Otahal Alun D. Hughes J. Andrew Black Willem Jan Bos Chen-Huan Chen Hao-Min Cheng Nathan Dwyer Peter Lacy Esben Laugesen Fuyou Liang Hack-Lyoung Kim Nobuyuki Ohte Sho Okada Stefano Omboni Christian Ott Telmo Pereira Giacomo Pucci Ronak Rajani Roland Schmieder Manish D. Sinha Ralph Stewart George A. Stouffer Kenji Takazawa Jiguang Wang Thomas Weber Berend E. Westerhof Bryan Williams Hirotsugu Yamada James E. Sharman Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (D.S.P., E.S., M.G.S., (...) Hypertension

Hypertension, Volume 80, Issue 2, Page 316-324, February 1, 2023. Background:Accurate blood pressure (BP) measurement is critical for optimal cardiovascular risk management. Age-related trajectories for cuff-measured BP accelerate faster in women compared with men, but whether cuff BP (...) (Hypertension)

29 July

Hypertension https://www.ahajournals.org/

11:00
Peripartum and Long-Term Maternal Cardiovascular Health After Preeclampsia - Veronica Giorgione Gwyneth Jansen Jamie Kitt Chahinda Ghossein-Doha Paul Leeson Basky Thilaganathan Molecular and Clinical Sciences Research Institute, St. George’s University of London, London, United Kingdom (V.G., B.T.). Fetal Medicine Unit, Department of Obstetrics and Gynaecology, St George’s University Hospitals NHS Foundation Trust, London, United Kingdom (V.G., B.T.). GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands (G.J., C.G.-D.). Department of Cardiology, Zuyderland Medical Centre, Heerlen, the Netherlands (G.J.). Oxford Cardiovascular (...) Hypertension

Hypertension, Volume 80, Issue 2, Page 231-241, February 1, 2023. There is widespread acceptance of the increased prevalence of cardiovascular diseases occurring within 1 to 2 decades in women following a preeclamptic pregnancy. More recent evidence suggests that the deranged biochemical and (...) (Hypertension)

26 July

Hypertension https://www.ahajournals.org/

11:00
Comparative Safety and Effectiveness of Aldosterone Antagonists Versus Beta-Blockers as Fourth Agents in Patients With Apparent Resistant Hypertension - Raj Desai Haesuk Park Joshua Brown Raj Mohandas Carl J. Pepine Steven M. Smith Department of Pharmaceutical Outcomes and Policy, College of Pharmacy (R.D., H.P., J.B., S.M.S.). Division of Nephrology, Hypertension and Renal Transplantation (R.M.) Division of Cardiovascular Medicine (C.J.P., S.M.S.) Department of Medicine, College of Medicine. Center for Integrative Cardiovascular and Metabolic Disease, University of Florida, Gainesville (S.M.S.). Hypertension

Hypertension, Ahead of Print. BACKGROUND:Limited evidence exists regarding long-term effectiveness and safety of aldosterone antagonists (AAs) versus beta blockers (BBs) as fourth-line antihypertensive agents in patients with resistant hypertension (RH). We evaluated the comparative (...) (Hypertension)
11:00
Estimated Benefits and Risks of Using a Reduced-Sodium, Potassium-Enriched Salt Substitute in India: A Modeling Study - Matti Marklund Fikru Tullu Sudhir Raj Thout Jie Yu Tammy Brady Lawrence J. Appel Bruce Neal Jason H.Y. Wu Rachita Gupta TheGeorge Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia (M.M., J.Y., B.N., J.H.Y.W.). The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (M.M., L.J.A.). Department of Public Health and Caring Sciences, Uppsala University, Sweden (M.M.). World Health Organization, Country Office India, New Delhi (F.T., R.G.). Research and Development Division, The George Institute for Global Health, Hyderabad, India (...) Hypertension

Hypertension, Ahead of Print. Background:Salt substitution (ie, replacement of table and cooking salt with potassium-enriched salt substitutes) is a promising strategy to reduce blood pressure and prevent cardiovascular disease, particularly in countries like India where there is high sodium (...) (Hypertension)

25 July

Hypertension https://www.ahajournals.org/

11:00
Association of Nap Frequency With Hypertension or Ischemic Stroke Supported by Prospective Cohort Data and Mendelian Randomization in Predominantly Middle-Aged European Subjects - Min-jing Yang Zhong Zhang Yi-jing Wang Jin-chen Li Qu-lian Guo Xiang Chen E. Wang Department of Anesthesiology, Central South University, Changsha, Hunan, China. (M.-j.Y., Z.Z., Q.-l.G.) National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, Hunan, China. (Y.-j.W., J.-c.L.) Department of Anesthesiology, Central South University, Changsha, Hunan, China. (X.C., E.W.) National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, Hunan, China. (X.C., E.W.) Xiangya Hospital, Centre for Medical Genetics, Hunan Key (...) Hypertension

Hypertension, Ahead of Print. Background and Purpose:The aim of this study was to investigate the association between daytime napping frequency and the incidence of essential hypertension or stroke as well as to validate causality in this relationship via Mendelian randomization (MR).Methods:We (...) (Hypertension)

22 July

Hypertension https://www.ahajournals.org/

11:01
Increased Placental sFLT1 (Soluble fms-Like Tyrosine Kinase Receptor-1) Drives the Antiangiogenic Profile of Maternal Serum Preceding Preeclampsia but Not Fetal Growth Restriction - Francesca Gaccioli Ulla Sovio Sungsam Gong Emma Cook D. Stephen Charnock-Jones Gordon C.S. Smith Department of Obstetrics and Gynaecology (F.G., U.S., S.G., E.C., D.S.C.-J., G.C.S.S.), University of Cambridge, United Kingdom. Centre for Trophoblast Research (F.G., U.S., D.S.C.-J., G.C.S.S.), University of Cambridge, United Kingdom. Hypertension

Hypertension, Volume 80, Issue 2, Page 325-334, February 1, 2023. Background:Preeclampsia and fetal growth restriction (FGR) are both associated with an increased ratio of sFLT1 (soluble fms-like tyrosine kinase-1) to PlGF (placenta growth factor) in maternal serum. In preeclampsia, it is (...) (Hypertension)
11:00
Retraction of: Insulin-Like Growth Factor 1 Alleviates High-Fat Diet–Induced Myocardial Contractile Dysfunction: Role of Insulin Signaling and Mitochondrial Function Hypertension

Hypertension, Ahead of Print. (Hypertension)

20 July

Hypertension https://www.ahajournals.org/

11:00
Resistance to Antihypertensive Drugs: Is Gut Microbiota the Missing Link? - Jun Kyoung Rohit R. Atluri Tao Yang Department of Physiology and Pharmacology, UT Microbiome Consortium, Center for Hypertension and Precision Medicine, College of Medicine and Life Sciences, University of Toledo, OH. Hypertension

Hypertension, Ahead of Print. Microbiota colonization begins at birth and continuously reshapes throughout the course of our lives, resulting in tremendous interindividual heterogeneity. Given that the gut microbiome, similar to the liver, houses many categories of catalytic enzymes, there is (...) (Hypertension)
11:00
Hypertension and Excess Risk for Severe COVID-19 Illness Despite Booster Vaccination - Joseph Ebinger Matthew Driver Sandy Joung Teresa Tran Denisse Barajas Min Wu Patrick Botting Jesse Navarrette Nancy Sun Susan Cheng Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA. Hypertension

Hypertension, Ahead of Print. (Hypertension)

18 July

Hypertension https://www.ahajournals.org/

11:00
Telomere Shortening in Hypertensive Heart Disease Depends on Oxidative DNA Damage and Predicts Impaired Recovery of Cardiac Function in Heart Failure - Moritz Brandt Hendrik Dörschmann Sana’a Khraisat Tanja Knopp Julia Ringen Sanela Kalinovic Venkata Garlapati Svenja Siemer Michael Molitor Sebastian Göbel Roland Stauber Susanne Helena Karbach Thomas Münzel Andreas Daiber Philip Wenzel Department of Cardiology (M.B., H.D., S.K., T.K., J.R., S.K., V.G., M.M., S.G., S.H.K., T.M., A.D., P.W.). Center for Thrombosis and Hemostasis (M.B., H.D., T.K., J.R., V.G., M.M., S.H.K., T.M., A.D., P.W.). Department of Otolaryngology, Head and Neck Surgery, 1-3 University Medical Center Mainz (UMC) (S.S., R.S.). German Center for Cardiovascular Research (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Heart failure (HF) coincides with cardiomyocyte telomere shortening. Arterial hypertension is the most prominent risk factor for HF. Both HF and arterial hypertension are associated with dysregulation of the neurohormonal axis. How neurohormonal (...) (Hypertension)
11:00
Effect of Financial Incentives on Hypertension Control: A Multicenter Randomized Controlled Trial in China - Liqiang Zheng Sitong Liu Yundi Jiao Yani Wu Yali Wang Zhecong Yu Jiahui Xu Yingxian Sun Zhaoqing Sun School of Public Health, Shanghai Jiao Tong University School of Medicine, China (L.Z., Y. Wu, J.X.). Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang (L.Z., S.L., Y.J., Y. Wang, Z.Y., Z.S.). Department of Cardiology, First Hospital of China Medical University, Shenyang (Y.S.). Hypertension

Hypertension, Ahead of Print. BACKGROUND:Poorly controlled hypertension is a great challenge to global public health. Incentive approaches, based on behavioral and economic concepts, may improve patients’ adherence to treatment.METHODS:We conducted a 2-arm randomized controlled trial to test (...) (Hypertension)

13 July

Hypertension https://www.ahajournals.org/

08:00
Correction to: DP1 (Prostaglandin D2 Receptor 1) Activation Protects Against Vascular Remodeling and Vascular Smooth Muscle Cell Transition to Myofibroblasts in Angiotensin II–Induced Hypertension in Mice Hypertension

Hypertension, Volume 79, Issue 8, Page e127-e127, August 1, 2022. (Hypertension)
08:00
Hypertension 2022 Update: Focusing on the Future - Rhian M. Touyz Research Institute of the McGill University Health Centre, Phil Gold Chair in Medicine, McGill University, Montreal, Québec, Canada. Hypertension

Hypertension, Volume 79, Issue 8, Page 1559-1562, August 1, 2022. (Hypertension)
08:00
Gut Microbiota: Friends or Foes for Blood Pressure-Lowering Drugs - Tenghao Zheng Francine Z. Marques Hypertension Research Laboratory, School of Biological Sciences, Monash University, Melbourne, Australia (T.Z., F.Z.M.). Heart Failure Research Group, Baker Heart and Diabetes Institute, Melbourne, Australia (F.Z.M.). Hypertension

Hypertension, Volume 79, Issue 8, Page 1602-1604, August 1, 2022. (Hypertension)
08:00
Distinct Trajectories of Overweight During Childhood and Elevated Blood Pressure at Late Adolescence - Zdenka Pausova Departments of Physiology and Nutritional Sciences, The Hospital for Sick Children, University of Toronto, Canada. Hypertension

Hypertension, Volume 79, Issue 8, Page 1614-1616, August 1, 2022. (Hypertension)
08:00
Plasma Lipidomic Profiles of Dairy Consumption: a New Window on Their Cardiometabolic Effects - Jean-Philippe Drouin-Chartier Nutrition, health and society (NUTRISS) Research Center, Institute of Nutrition and Functional Foods (INAF), Laval University, Québec, CA. Faculty of pharmacy, Laval University, Québec, CA. Hypertension

Hypertension, Volume 79, Issue 8, Page 1629-1632, August 1, 2022. (Hypertension)
08:00
Response to Isolated Diastolic Hypertension and Risk of Cardiovascular Disease: Controversies in Hypertension - Con Side of the Argument - Alan P. Jacobsen Myles McKittrick Natalie Daya Mahmoud Al Rifai John W. McEvoy Hypertension

Hypertension, Volume 79, Issue 8, Page 1570-1570, August 1, 2022. (Hypertension)
08:00
Response to Isolated Diastolic Hypertension and Risk of Cardiovascular Disease: Controversies in Hypertension - Con Side of the Argument - Yuichiro Yano Hyeon Chang Kim Hokyou Lee Nazar Azahar Sabrina Ahmed Kaori Kitaoka Hidehiro Kaneko Fujimi Kawai Atsushi Mizuno Anthony J. Viera Hypertension

Hypertension, Volume 79, Issue 8, Page 1579-1579, August 1, 2022. (Hypertension)
08:00
Isolated Diastolic Hypertension and Risk of Cardiovascular Disease: Controversies in Hypertension—Con Side of the Argument - Alan P. Jacobsen Myles McKittrick Natalie Daya Mahmoud Al Rifai John W. McEvoy Ciccarone Center for the Prevention of Cardiovascular Disease, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (A.P.J., J.W.M.). National Institute for Prevention and Cardiovascular Health, National University of Ireland Galway, Galway (M.M., J.W.M.). Welch Center for Prevention, Epidemiology and Clinical Research, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (N.D.). Section of Cardiology, Baylor College of Medicine, Houston, TX (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1571-1578, August 1, 2022. (Hypertension)
08:00
Isolated Diastolic Hypertension and Risk of Cardiovascular Disease: Controversies in Hypertension - Pro Side of the Argument - Yuichiro Yano Hyeon Chang Kim Hokyou Lee Nazar Azahar Sabrina Ahmed Kaori Kitaoka Hidehiro Kaneko Fujimi Kawai Atsushi Mizuno Anthony J. Viera Department of Advanced Epidemiology Noncommunicable Disease (NCD) Epidemiology Research Center (Y.Y., N.A., S.A., K.K.), Shiga University of Medical Science, Otsu, Japan. Department of Public Health (N.A., S.A., K.K.), Shiga University of Medical Science, Otsu, Japan. Department of Family Medicine and Community Health, Duke University, NC (Y.Y., A.J.V.). Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1563-1570, August 1, 2022. Isolated diastolic hypertension (IDH), defined as diastolic blood pressure in the hypertensive range but systolic blood pressure not in the hypertensive range, is not uncommon (...) (Hypertension)

11 July

Hypertension https://www.ahajournals.org/

11:00
Ang II (Angiotensin II)–Induced FGFR1 (Fibroblast Growth Factor Receptor 1) Activation in Tubular Epithelial Cells Promotes Hypertensive Kidney Fibrosis and Injury - Zheng Xu Wu Luo Lingfeng Chen Zaishou Zhuang Daona Yang Jianchang Qian Zia A. Khan Xinfu Guan Yi Wang Xiaokun Li Guang Liang Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang, China (Z.X., W.L., J.Q., Y.W., X.L., G.L.). School of Pharmaceutical Sciences, Hangzhou Medical College, Zhejiang, China (Z.X., L.C., G.L.). Department of Cardiology and Medical Research Center, The First Affiliated Hospital, Wenzhou Medical University, Zhejiang, China (W.L.). The Affiliated Cangnan Hospital, Wenzhou Medical University, Zhejiang, China (Z.Z., (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Elevated Ang II (angiotensin II) level leads to a range of conditions, including hypertensive kidney disease. Recent evidences indicate that FGFR1 (fibroblast growth factor receptor 1) signaling may be involved in kidney injuries. In this study, we (...) (Hypertension)

8 July

Hypertension https://www.ahajournals.org/

11:00
Systolic Blood Pressure and Effects of Screening for Atrial Fibrillation With Long-Term Continuous Monitoring (a LOOP Substudy) - Lucas Yixi Xing Søren Zöga Diederichsen Søren Højberg Derk W. Krieger Claus Graff Morten Salling Olesen Axel Brandes Lars Køber Ketil Jørgen Haugan Jesper Hastrup Svendsen Department of Cardiology, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark (L.Y.X., S.Z.D., M.S.O., L.K., J.H.S.). Department of Cardiology, Bispebjerg Hospital, Copenhagen University Hospital, Denmark (S.Z.D., S.H.). Department of Neurology, Mediclinic City Hospital, Dubai,United Arabic Emirates (D.W.K.). Department of Neuroscience, Mohammed Bin Rashid University of Medicine and Health Science, Dubai, (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Hypertension is a well-known risk factor for atrial fibrillation (AF), but data on the interaction between systolic blood pressure (SBP) and effects of continuous AF screening are lacking.METHODS:The LOOP Study randomized AF-naive individuals aged 70 to (...) (Hypertension)

7 July

Hypertension https://www.ahajournals.org/

11:00
Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Hypertension - J. David Spence Tilo Grosser Garret A. FitzGerald Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Ontario, Canada (J.D.S.). Institute for Translational Medicine and Therapeutics, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia (T.G., G.A.F.). Department of Translational Pharmacology, Medical School EWL, Bielefeld University, Germany (...) Hypertension

Hypertension, Ahead of Print. Acetaminophen is widely regarded as a safe therapy for pain and fever in patients with cardiovascular disease and those taking anticoagulants. However, recent studies report that acetaminophen, like most other nonsteroidal anti-inflammatory drugs, increases blood (...) (Hypertension)
11:00
Machine Learning–Based Prediction of Masked Hypertension Among Children With Chronic Kidney Disease - Sunjae Bae Joshua A. Samuels Joseph T. Flynn Mark M. Mitsnefes Susan L. Furth Bradley A. Warady Derek K. Ng Department of Surgery, Johns Hopkins University, Baltimore, MD (S.B.). University of Texas Health Sciences Center, Houston (J.A.S.). Department of Pediatrics, University of Washington (J.T.F.). Division of Nephrology, Seattle Children’s Hospital, Washington (J.T.F.). Division of Nephrology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, OH (M.M.M.). Division of Nephrology, Department of Pediatrics, Children’s Hospital of Philadelphia, PA (S.L.F.). Department (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Ambulatory blood pressure monitoring (ABPM) is routinely performed in children with chronic kidney disease to identify masked hypertension, a risk factor for accelerated chronic kidney disease progression. However, ABPM is burdensome, and developing an (...) (Hypertension)
11:00
Increased Risk of Preeclampsia in Women With a Genetic Predisposition to Elevated Blood Pressure - Anna Kivioja Elli Toivonen Jaakko Tyrmi Sanni Ruotsalainen Samuli Ripatti Heini Huhtala Tiina Jääskeläinen Seppo Heinonen Eero Kajantie Juha Kere Katja Kivinen Anneli Pouta Tanja Saarela Hannele Laivuori Department of Obstetrics and Gynecology, Tampere University Hospital, Finland (A.K., E.T., H.L.). Center for Child, Adolescent, and Maternal Health, Faculty of Medicine and Health Technology, Tampere University, Finland. (A.K., E.T., J.T., H.L.) Faculty of Social Sciences, Tampere University, Finland. (H.H.) Computational Medicine, Faculty of Medicine, University of Oulu, Finland. (J.T.) (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Preeclampsia causes significant maternal and perinatal morbidity. Genetic factors seem to affect the onset of the disease. We aimed to investigate whether the polygenic risk score for blood pressure (BP; BP-PRS) is associated with preeclampsia, its (...) (Hypertension)

30 June

Hypertension https://www.ahajournals.org/

11:00
Seasonal Variation in Day-by-Day Home Blood Pressure Variability and Effect on Cardiovascular Disease Incidence - Keisuke Narita Satoshi Hoshide Kazuomi Kario Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University School of Medicine, Tochigi, Japan. Hypertension

Hypertension, Ahead of Print. Background:Although day-by-day home blood pressure (BP) variability (BPV) has been associated with cardiovascular disease (CVD) risk, it remains unclear whether this association differs from season to season. The present study aimed to assess seasonal variation in (...) (Hypertension)

29 June

Hypertension https://www.ahajournals.org/

11:02
Influence of Obstructive Sleep Apnea Severity on Muscle Sympathetic Nerve Activity and Blood Pressure: a Systematic Review and Meta-Analysis - Lauren E. Maier Brittany A. Matenchuk Ana Vucenovic Allison Sivak Margie H. Davenport Craig D. Steinback Neurovascular Health Laboratory, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Canada. (L.E.M., A.V., C.D.S.) Program for Pregnancy and Postpartum Health, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Canada. (B.A.M., M.H.D.) H.T. Coutts Education and Physical Education Library, University of Alberta, Edmonton, Canada. (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:We conducted meta-analyses to identify relationships between obstructive sleep apnea (OSA) severity, muscle sympathetic nerve activity (MSNA), and blood pressure (BP). We quantified the effect of OSA treatment on MSNA.METHODS:Structured searches of (...) (Hypertension)
11:01
Aldosterone as a Mediator of Cardiovascular Damage - Fabrizio Buffolo Martina Tetti Paolo Mulatero Silvia Monticone Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Torino, Italy. Hypertension

Hypertension, Ahead of Print. Besides the physiological regulation of water, sodium, and potassium homeostasis, aldosterone modulates several physiological and pathological processes in the cardiovascular system. At the vascular level, aldosterone excess stimulates endothelial dysfunction and (...) (Hypertension)
11:00
Angiotensin Receptor Blockers Are Associated With a Lower Risk of Progression From Mild Cognitive Impairment to Dementia - Zhenhong Deng Jingru Jiang Jia Wang Dong Pan Yingying Zhu Honghong Li Xiaoni Zhang Xiaohuan Liu Yongteng Xu Yi Li Yamei Tang Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. (Z.D., J.J., J.W., D.P., Y.Z., H.L., X.Z.,X.L., Y.X., Y.L., Y.T.) Division of Clinical Research Design, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. (Y.Z., Y.T.) Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. (Y.T.) Guangdong (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Previous studies found that antihypertensive medications (AHMs) acting on the renin-angiotensin system had the potential to reduce the progression from mild cognitive impairment to dementia. However, it remains unclear whether this association differs (...) (Hypertension)
11:00
Blood Pressure Intervention and Control in the SPRINT - William C. Cushman Robert J. Ringer Carlos J. Rodriguez Gregory W. Evans Jeffrey T. Bates Jeffrey A. Cutler Amret Hawfield Dalane W. Kitzman Ilya M. Nasrallah Suzanne Oparil John Nord Vasilios Papademetriou Karen Servilla Peter Van Buren Paul K. Whelton Jeff Whittle Jackson T. Wright Department of Preventive Medicine, University of Tennessee Health Science Center, and Medical Service, Veterans Affairs Medical Center, Memphis (W.C.C.). Department of Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (R.J.R.). Departments of (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:The SPRINT (Systolic Blood Pressure Intervention Trial) demonstrated reductions in major cardiovascular disease events and mortality with an intensive systolic blood pressure (SBP) goal intervention. However, a detailed description of the blood pressure (...) (Hypertension)
11:01
Age and Blood Pressure Contribute to Aortic Cell and Tissue Stiffness Through Distinct Mechanisms - Ben Ma Elaina Melton Robert Wiener Ning Zhou Wenqian Wu Lo Lai Charles Wang Kevin D. Costa Hongyu Qiu Center for Molecular and Translational Medicine, Institute of Biomedical Sciences, Georgia State University, Atlanta, GA (B.M., E.M., W.W., L.L., H.Q.). Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY (R.W., K.D.C.). Division of Physiology, Department of Basic Sciences (B.M., N.Z., H.Q.), School of Medicine, Loma Linda University, CA. Department of Basic Sciences & Center for Genomics (C.W.), School of Medicine, (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1777-1788, August 1, 2022. Background:Aortic stiffening is strongly associated with both aging and hypertension, but the underlying mechanisms remain unclear. We hypothesized that aging-induced aortic stiffness is mediated by a mechanism differing from (...) (Hypertension)

28 June

Hypertension https://www.ahajournals.org/

11:00
Association of Blood Pressure–Related Increase in Vascular Stiffness on Other Measures of Target Organ Damage in Youth - Jessica E. Haley Shalayna A. Woodly Stephen R. Daniels Bonita Falkner Michael Ferguson Joseph T. Flynn Coral Hanevold Stephen R. Hooper Julie R. Ingelfinger Philip R. Khoury Marc B. Lande Lisa J. Martin Kevin E. Meyers Mark Mitsnefes Richard C. Becker Bernard Rosner Joshua Samuels Andrew Tran Elaine Urbina Rady Children’s Hospital San Diego, CA (J.E.H.). Cincinnati Children’s Hospital Medical Center, OH (S.A.W., P.R.K., L.J.M., M.M., R.C.B., A.T., E.U.). Children’s Hospital Colorado, Denver (S.R.D.). Thomas Jefferson University (B.F.). Boston Children’s Hospital (M.F.). Department of (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Hypertension-related increased arterial stiffness predicts development of target organ damage (TOD) and cardiovascular disease. We hypothesized that blood pressure (BP)–related increased arterial stiffness is present in youth with elevated BP and is (...) (Hypertension)
11:00
Antenatal Dexamethasone Exposure Impairs Vascular Contractile Functions via Upregulating IP3 Receptor 1 and Cav1.2 in Adult Male Offspring - Ting Xu Bingyu Ji Lingjun Li Jiahui Lei Meng Zhao Miao Sun Zhice Xu Qinqin Gao Institute for Fetology, First Hospital of Soochow University, Suzhou, China (T.X., B.J., L.L., J.L., M.Z., M.S., Z.X., Q.G.). Hypertension

Hypertension, Ahead of Print. BACKGROUND:Administration of antenatal glucocorticoids remains common practice for treating preterm delivery. Antenatal glucocorticoid exposure increased the risk of developing vascular diseases in later life, but the precise mechanisms remain unclear. This study (...) (Hypertension)

22 June

Hypertension https://www.ahajournals.org/

11:00
Voluntary Exercise Eliminates Maternal Gestational Hypertension–Induced Hypertensive Response Sensitization to Postweaning High-Fat Diet in Male Adult Offspring - Baojian Xue Yang Yu Terry G. Beltz Fang Guo Shun-Guang Wei Alan Kim Johnson Departments of Psychological and Brain Sciences, University of Iowa, Iowa City. (B.X., T.G.B., F.G., A.K.J.) Neuroscience and Pharmacology, University of Iowa, Iowa City. (A.K.J.) Health and Human Physiology, University of Iowa, Iowa City. (A.K.J.) Internal Medicine, University of Iowa, Iowa City. (Y.Y., S.-G.W.) the François M. Abboud Cardiovascular Research Center, University of Iowa, Iowa City. (S.-G.W., (...) Hypertension

Hypertension, Ahead of Print. BACKGROUND:Exercise has profound effects on cardiovascular function and metabolism in both physiological and pathophysiological states. The present study tested whether voluntary exercise would protect male offspring against maternal gestational (...) (Hypertension)

21 June

Hypertension https://www.ahajournals.org/

11:00
Digital Therapeutics in Hypertension: Evidence and Perspectives - Kazuomi Kario Noriko Harada Ayako Okura Division of Cardiovascular Medicine, School of Medicine, Jichi Medical University, Tochigi, Japan. Hypertension

Hypertension, Ahead of Print. Digital therapeutics refers to the use of evidence-based therapeutic interventions driven by high-quality software programs to treat, manage, or prevent a medical condition. This approach is being increasingly investigated for the management of hypertension, a (...) (Hypertension)
11:00
Cathepsin K Deficiency Prevented Kidney Damage and Dysfunction in Response to 5/6 Nephrectomy Injury in Mice With or Without Chronic Stress - Xueling Yue Limei Piao Hailong Wang Zhe Huang Xiangkun Meng Takeshi Sasaki Aiko Inoue Kae Nakamura Ying Wan Shengnan Xu Guo-Ping Shi Weon Kim Toyoaki Murohara Masafumi Kuzuya Xian Wu Cheng Department of Cardiology and Hypertension, Yanbian University Hospital, Yanji, Jilin, People's Republic of China (X.Y., L.P., H.W., Z.H., X.M., Y.W., S.X., X.W.C.). Department of Community Health Care and Geriatrics (X.Y., Z.H., X.M., M.K.), Nagoya University Graduate School of Medicine, Japan. Institute of Innovation for Future Society (A.I., M.K.), Nagoya University Graduate School of Medicine, Japan. (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1713-1723, August 1, 2022. Background:Chronic psychological stress is a risk factor for kidney disease, including kidney dysfunction and hypertension. Lysosomal CatK (cathepsin K) participates in various human pathobiologies. We investigated the role of (...) (Hypertension)

20 June

Hypertension https://www.ahajournals.org/

11:00
Variation in Mean Arterial Pressure Increases Falls Risk in Elderly Physically Frail and Prefrail Individuals Treated With Antihypertensive Medication - Sultana Monira Hussain Michael E. Ernst Anna L. Barker Karen L. Margolis Christopher M. Reid Johannes T. Neumann Andrew M. Tonkin Thao Le Thi Phuong Lawrence J Beilin Thao Pham Enayet K. Chowdhury Flavia M. Cicuttini Julia Gilmartin-Thomas Prudence R. Carr John J McNeil School of Public Health and Preventive Medicine, Monash University, Victoria, Australia (S.M.H., A.L.B., C.M.R., J.T.N., A.M.T., T.L.T.P., T.P., E.K.C., F.M.C., J.G.-T., P.R.C., J.J.M.). Department of Medical Education, Melbourne Medical School, The University of Melbourne, Victoria, Australia. (S.M.H.) Department of (...) Hypertension

Hypertension, Ahead of Print. Background:Impaired cerebral blood flow has been associated with an increased risk of falls. Mean arterial pressure (MAP) and variability in MAP have been reported to affect cerebral blood flow but their relationships to the risk of falls have not previously been (...) (Hypertension)

16 June

Hypertension https://www.ahajournals.org/

11:00
Effects of a Liquefied Petroleum Gas Stove Intervention on Gestational Blood Pressure: Intention-to-Treat and Exposure-Response Findings From the HAPIN Trial - Wenlu Ye Kyle Steenland Ashlinn Quinn Jiawen Liao Kalpana Balakrishnan Ghislaine Rosa Florien Ndagijimana Jean de Dieu Ntivuguruzwa Lisa M. Thompson John P. McCracken Anaité Díaz-Artiga Joshua P. Rosenthal Aris Papageorghiou Victor G. Davila-Roman Ajay Pillarisetti Michael Johnson Jiantong Wang Laura Nicolaou William Checkley Jennifer L. Peel Thomas F. Clasen Gangarosa Department of Environmental Health, Rollins School of Public Health (W.Y., K.S., A. Pillarisetti, T.F.C.), Emory University, Atlanta, GA. Nell Hodgson Woodruff School of Nursing (L.M.T.), Emory University, Atlanta, GA. (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1887-1898, August 1, 2022. Background:Approximately 3 to 4 billion people worldwide are exposed to household air pollution, which has been associated with increased blood pressure (BP) in pregnant women in some studies.Methods:We recruited 3195 pregnant (...) (Hypertension)
11:00
Revascularization for Renovascular Disease: A Scientific Statement From the American Heart Association - Vivek Bhalla Stephen C. Textor Joshua A. Beckman Ana I. Casanegra Christopher J. Cooper Esther S.H. Kim James M. Luther Sanjay Misra Gustavo S. Oderich Hypertension

Hypertension, Volume 79, Issue 8, Page e128-e143, August 1, 2022. Renovascular disease is a major causal factor for secondary hypertension and renal ischemic disease. However, several prospective, randomized trials for atherosclerotic disease failed to demonstrate that renal revascularization (...) (Hypertension)
06:00
Control of Blood Pressure and Risk of Cardiovascular Disease and Mortality in Elderly Chinese: A Real-World Prospective Cohort Study - Anxin Wang Xue Tian Yingting Zuo Shuohua Chen Yijun Zhang Xiaoli Zhang Xuan Deng Qin Xu Penglian Wang Shouling Wu Yong Zhou Department of Neurology, Beijing Tiantan Hospital (A.W., X.T., Y. Zuo, Y. Zhang, X.Z., Q.X., P.W.), Capital Medical University. China National Clinical Research Center for Neurological Diseases (A.W., X.T., Y. Zuo, Y. Zhang, X.Z., Q.X., P.W.), Capital Medical University. Department of Epidemiology and Health Statistics, School of Public Health (X.T., Y. Zuo), Capital Medical University. Beijing Municipal Key Laboratory of Clinical Epidemiology, China (X.T., Y. Zuo). (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1866-1875, August 1, 2022. Background:The STEP trial (Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients) showed that older hypertensive patients might benefit from a target systolic blood pressure (SBP) of 110 (...) (Hypertension)

15 June

Hypertension https://www.ahajournals.org/

11:00
SGLT2 Inhibition via Empagliflozin Improves Endothelial Function and Reduces Mitochondrial Oxidative Stress: Insights From Frail Hypertensive and Diabetic Patients - Pasquale Mone Fahimeh Varzideh Stanislovas S. Jankauskas Antonella Pansini Angela Lombardi Salvatore Frullone Gaetano Santulli Department of Medicine, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, Einstein-Sinai Diabetes Research Center (ES-DRC), Albert Einstein College of Medicine, New York City, NY (P.M., F.V., S.S.J., A.L., G.S.). ASL Avellino, Italy (P.M., A.P., S.F.). Department of Molecular Pharmacology, Institute for Neuroimmunology and Inflammation (INI), Wilf Family Cardiovascular Research Institute, Albert Einstein College of (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1633-1643, August 1, 2022. Background:Frailty is a multidimensional condition often diagnosed in older adults with hypertension and diabetes, and both these conditions are associated with endothelial dysfunction and oxidative stress. We investigated the (...) (Hypertension)

13 June

Hypertension https://www.ahajournals.org/

11:00
Per- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women's Health Across the Nation - Ning Ding Carrie A. Karvonen-Gutierrez Bhramar Mukherjee Antonia M. Calafat Siobán D. Harlow Sung Kyun Park Department of Epidemiology (N.D., C.A.K.-G., S.D.H., S.K.P.), School of Public Health, University of Michigan, Ann Arbor. Department of Biostatistics (B.M.), School of Public Health, University of Michigan, Ann Arbor. Department of Environmental Health Sciences (S.K.P.), School of Public Health, University of Michigan, Ann Arbor. Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1876-1886, August 1, 2022. Background:Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are ubiquitous synthetic chemicals that may disrupt blood pressure controls; however, human evidence to support this hypothesis is scant. We examined the association (...) (Hypertension)

10 June

Hypertension https://www.ahajournals.org/

11:00
Management and Outcomes of Primary Aldosteronism in Pregnancy: A Systematic Review - Viola Sanga Giacomo Rossitto Teresa Maria Seccia Gian Paolo Rossi Hypertension and Emergency Unit, Department of Medicine - DIMED, University of Padua, Italy. (V.S., T.M.S., G.P.R.) PhD Arterial Hypertension and Vascular Biology, Department of Medicine - DIMED, University of Padua, Italy. (V.S.) Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (G.R.). Hypertension

Hypertension, Ahead of Print. Primary aldosteronism (PA) in pregnancy (PAP) can be a serious condition and is challenging to diagnose. This study was conceived to help in the diagnosis of PAP and provide suggestions on management of PAP based on evidence retrieved using a Population, (...) (Hypertension)
11:00
IsoLGs (Isolevuglandins) Drive Neutrophil Migration in Hypertension and Are Essential for the Formation of Neutrophil Extracellular Traps - Jaya Krishnan Néstor de la Visitación Elizabeth M. Hennen Venkataraman Amarnath David G. Harrison David M. Patrick Division of Clinical Pharmacology (J.K., N.d.l.V., V.A., D.G.H., D.M.P.), Department of Medicine, Vanderbilt University Medical Center. Division of Cardiovascular Medicine (D.G.H., D.M.P.), Department of Medicine, Vanderbilt University Medical Center. Department of Biomedical Engineering, Vanderbilt University (E.M.H.). Department of Veterans Affairs, Nashville, TN (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1644-1655, August 1, 2022. Background:IsoLGs (isolevuglandins) are electrophilic products of lipid peroxidation formed in the presence of reactive oxygen species. IsoLGs contribute to hypertension by an unknown mechanism. Studies have shown that reactive (...) (Hypertension)
11:00
Effects of Ramipril on Biomarkers of Endothelial Dysfunction and Inflammation in Hypertensive Children on Maintenance Hemodialysis: the SEARCH Randomized Placebo-Controlled Trial - Areej Mohamed Ateya Ihab El Hakim Sara Mahmoud Shahin Radwa El Borolossy Reinhold Kreutz Nagwa Ali Sabri Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.M.A., S.M.S., R.E.B., N.A.S.). Charité – Universitätsmedizin Berlin, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany (A.M.A., R.K.). Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt (I.E.H.). Hypertension

Hypertension, Volume 79, Issue 8, Page 1856-1865, August 1, 2022. Background:Hypertension, endothelial dysfunction, and inflammation are associated with increased cardiovascular mortality in end-stage kidney disease. We evaluated the effects of ACE (angiotensin-converting enzyme) inhibition on (...) (Hypertension)

8 June

Hypertension https://www.ahajournals.org/

11:00
Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na+/H+ Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway - Xiaoliang Jiang Yunpeng Liu Xin-Yang Zhang Xue Liu Xing Liu Xianxian Wu Pedro A. Jose Shun Duan Fu-Jian Xu Zhiwei Yang NHC Key Laboratory of Human Disease Comparative Medicine (The Institute of Laboratory Animal Sciences, CAMS&PUMC), National Human Diseases Animal Model Resource Center, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, P.R. China (X.J., Y.L., Xue Liu, Xing Liu, X.W., Z.Y.). Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education, Beijing Laboratory of (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1668-1679, August 1, 2022. Background:The present study directly tested the crucial role of intestinal gastrin/CCKBR (cholecystokinin B receptor) in the treatment of salt-sensitive hypertension.Methods:Adult intestine-specificCckbr-knockout mice (...) (Hypertension)
11:00
Association Between the Gut Microbiome and Their Metabolites With Human Blood Pressure Variability - Evany Dinakis Michael Nakai Paul Gill Rosilene Ribeiro Stephanie Yiallourou Yusuke Sata Jane Muir Melinda Carrington Geoffrey A. Head David M. Kaye Francine Z. Marques Hypertension Research Laboratory, School of Biological Sciences (E.D., M.N., F.Z.M), Monash University, Melbourne, Australia. Department of Gastroenterology (P.G., J.M.), Monash University, Melbourne, Australia. Central Clinical School, Faculty of Medicine Nursing and Health Sciences (Y.S., D.M.K.), Monash University, Melbourne, Australia. Department of Pharmacology, Faculty of Medicine Nursing and Health Sciences (G.A.H.), (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1690-1701, August 1, 2022. Background:Blood pressure (BP) variability is an independent risk factor for cardiovascular events. Recent evidence supports a role for the gut microbiota in BP regulation. However, whether the gut microbiome is associated with (...) (Hypertension)
11:00
MANP Activation Of The cGMP Inhibits Aldosterone Via PDE2 And CYP11B2 In H295R Cells And In Mice - Yang Chen Seethalakshmi R. Iyer Viacheslav O. Nikolaev Fabio Naro Manuela Pellegrini Silvia Cardarelli Xiao Ma Hon-Chi Lee John C. Burnett Cardiorenal Research Laboratory, Department of Cardiovascular Medicine (Y.C., S.R.I., X.M., J.C.B.), Mayo Clinic, Rochester MN. Department of Cardiovascular Medicine (H.-C.L.), Mayo Clinic, Rochester MN. The Institute for Diabetes‚ Obesity‚ and Metabolism, University of Pennsylvania, Philadelphia (Y.C.). Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Germany (V.O.N.). Department of Anatomical, (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1702-1712, August 1, 2022. Background:Aldosterone is a critical pathological driver for cardiac and renal diseases. We recently discovered that mutant atrial natriuretic peptide (MANP), a novel atrial natriuretic peptide (ANP) analog, possessed more potent (...) (Hypertension)
08:00
Correction to: Prospective Evaluation of International Prediction of Pregnancy Complications Collaborative Network Models for Prediction of Preeclampsia: Role of Serum sFlt-1 at 11–13 Weeks’ Gestation Hypertension

Hypertension, Volume 79, Issue 7, Page e113-e113, July 1, 2022. (Hypertension)

6 June

Hypertension https://www.ahajournals.org/

11:00
Uric Acid and Hypertension: a Review of Evidence and Future Perspectives for the Management of Cardiovascular Risk - Claudio Borghi Davide Agnoletti Arrigo Francesco Giuseppe Cicero Empar Lurbe Agostino Virdis Department of Medical and Surgical Science-IRCCS S.Orsola, University of Bologna, Italy (C.B., D.A., A.F.G.C.). Department of Pediatrics, University of Valencia, Spain (E.L.). Department of Clinical and Experimental Medicine, University of Pisa, Italy (A.V.). Hypertension

Hypertension, Ahead of Print. Uric acid is the final product of purine metabolism, and its increased serum levels have been directly involved in the pathogenesis and natural history of hypertension. The relationship between elevated uric acid and hypertension has been proven in both animals and (...) (Hypertension)

3 June

Hypertension https://www.ahajournals.org/

11:00
Uric Acid Expression in Carotid Atherosclerotic Plaque and Serum Uric Acid Are Associated With Cerebrovascular Events - Valentina Nardi Federico Franchi Megha Prasad Erica M. Fatica Mariam P. Alexander Melanie C. Bois Josephine Lam Ravinder J. Singh Fredric B. Meyer Giuseppe Lanzino Yuning Xiong Esther Lutgens Lilach O. Lerman Amir Lerman Department of Cardiovascular Medicine (V.N., F.F., M.P., J.L., Y.X., E.L., A.L.), Mayo Clinic, Rochester, MN. Department of Laboratory of Medicine and Pathology (E.M.F., M.P.A., M.C.B., R.J.S.), Mayo Clinic, Rochester, MN. Department of Neurosurgery (F.B.M., G.L.), Mayo Clinic, Rochester, MN. Department of Nephrology and Hypertension (L.O.L.), Mayo Clinic, Rochester, (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1814-1823, August 1, 2022. Background:Uric acid (UA) concentration within carotid plaque and its association with cerebrovascular events have not been detected or quantified. Systemically, serum UA is a marker of inflammation and risk factor for (...) (Hypertension)
11:00
Effect of Renin-Angiotensin-Aldosterone System Inhibitors on the Rupture Risk Among Hypertensive Patients With Intracranial Aneurysms - Ping Zhong Zhiwen Lu Zhangyu Li Tianxiao Li Qing Lan Jianmin Liu Zhanxiang Wang Sifang Chen Qinghai Huang Department of Neurosurgery (P.Z., Z. Li, S.C.), School of Medicine, Xiamen University, China. BE and Phase I Clinical Trial Center (P.Z.), School of Medicine, Xiamen University, China. Department of Neurosurgery, Xiamen Key Laboratory of Brain Center (Z.W.), School of Medicine, Xiamen University, China. The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University and Department of Neuroscience, Institute of Neurosurgery (Z.W.), School of Medicine, Xiamen (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1475-1486, July 1, 2022. Background:Mounting experimental evidence supports the concept that the RAAS (renin-angiotensin-aldosterone system) is involved in the pathogenesis of intracranial aneurysm rupture. However, whether RAAS inhibitors could reduce the (...) (Hypertension)

2 June

Hypertension https://www.ahajournals.org/

11:01
Novel Drug Delivery Technologies and Targets for Renal Disease - Alejandro R. Chade Gene L. Bidwell The Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson. (A.R.C.) the Department of Medicine, University of Mississippi Medical Center, Jackson. (A.R.C.) the Department of Radiology, University of Mississippi Medical Center, Jackson. (A.R.C.) the Department of Neurology, University of Mississippi Medical Center, Jackson. (G.L.B.) the Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson. (G.L.B.) the Department of Pharmacology, University of Mississippi Medical Center, Jackson. (...) Hypertension

Hypertension, Ahead of Print. The burden of acute and chronic kidney diseases to the health care system is exacerbated by the high mortality that this disease carries paired with the still limited availability of comprehensive therapies. A reason partially resides in the complexity of the (...) (Hypertension)
11:01
Performance of Confirmatory Tests for Diagnosing Primary Aldosteronism: a Systematic Review and Meta-Analysis - Alexander A. Leung Christopher J. Symonds Gregory L. Hundemer Paul E. Ronksley Diane L. Lorenzetti Janice L. Pasieka Adrian Harvey Gregory A. Kline Division of Endocrinology and Metabolism, Department of Medicine (A.A.L., C.J.S., G.A.K.), University of Calgary, AB. Department of Community Health Sciences (A.A.L., P.E.R., D.L.L.), University of Calgary, AB. Department of Surgery (J.L.P., A.H.), University of Calgary, AB. Department of Oncology (J.L.P., A.H.), University of Calgary, AB. Division of Nephrology, Department of Medicine and the Ottawa Hospital Research Institute, University of (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1835-1844, August 1, 2022. Background:Confirmatory tests are recommended for diagnosing primary aldosteronism, but the supporting evidence is unclear.Methods:We searched Medline, EMBASE, and the Cochrane Central Register of Controlled Trials. Studies (...) (Hypertension)
11:00
Dapagliflozin Attenuates Sympathetic and Pressor Responses to Stress in Young Prehypertensive Spontaneously Hypertensive Rats - Han-Kyul Kim Rie Ishizawa Ayumi Fukazawa Zhongyun Wang Ursa Bezan Petric Ming Chang Hu Scott A. Smith Masaki Mizuno Wanpen Vongpatanasin Departments of Internal Medicine-Hypertension Section (H.-K.K., Z.W., U.B.P., W.V.), University of Texas Southwestern Medical Center, Dallas, TX. Applied Clinical Research (H.-K.K., R.I., A.F., S.A.S., M.M.), University of Texas Southwestern Medical Center, Dallas, TX. Internal Medicine-Renal Division (M.C.H.), University of Texas Southwestern Medical Center, Dallas, TX. Pak Center of Mineral Metabolism and Clinical Research (M.C.H., W.V.), University of (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1824-1834, August 1, 2022. Background:SGLT2i (sodium-glucose cotransporter 2 inhibitor), a class of anti-diabetic medications, is shown to reduce blood pressure (BP) in hypertensive patients with type 2 diabetes. Mechanisms underlying this action are (...) (Hypertension)
11:00
Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension - Tanika N. Kelly Xiao Sun Karen Y. He Michael R. Brown Sarah A. Gagliano Taliun Jacklyn N. Hellwege Marguerite R. Irvin Xuenan Mi Jennifer A. Brody Nora Franceschini Xiuqing Guo Shih-Jen Hwang Paul S. de Vries Yan Gao Arden Moscati Girish N. Nadkarni Lisa R. Yanek Tali Elfassy Jennifer A. Smith Ren-Hua Chung Amber L. Beitelshees Amit Patki Stella Aslibekyan Brandon M. Blobner Juan M. Peralta Themistocles L. Assimes Walter R. Palmas Chunyu Liu Adam P. Bress Zhijie Huang Lewis C. Becker Chii-Min Hwa Jeffrey R. O’Connell Jenna C. Carlson Helen R. Warren Sayantan Das Ayush Giri Lisa W. Martin (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1656-1667, August 1, 2022. Background:The availability of whole-genome sequencing data in large studies has enabled the assessment of coding and noncoding variants across the allele frequency spectrum for their associations with blood pressure.Methods:We (...) (Hypertension)
11:00
Longitudinal Changes in Cardiac Structure and Function in Pediatric Kidney Transplant Recipients - Isabel de Verteuil Jessica Fitzpatrick Ana Catalina Alvarez Elias Tonny Banh Jovanka Vasilevska-Ristovska Jordan Browne Bianca C. Bondi Wei Hui Cameron Slorach Chia Wei Teoh Valerie Langlois Luc Mertens Rulan S. Parekh Child Health Evaluative Sciences, Research Institute (I.d.V., J.F., T.B., J.V.-R., J.B., B.C.B., R.S.P.), The Hospital for Sick Children, Toronto, Ontario, Canada. Labatt Family Heart Center (W.H., C.S., L.M.), The Hospital for Sick Children, Toronto, Ontario, Canada. Division of Nephrology, (A.C.A.E., C.W.T., V.L., R.S.P.), The Hospital for Sick Children, Toronto, Ontario, (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1680-1689, August 1, 2022. Background:Cardiovascular disease results in increased morbidity and mortality in pediatric kidney transplant recipients. Longitudinal changes in cardiac structure and function and the association with blood pressure control over (...) (Hypertension)

31 May

Hypertension https://www.ahajournals.org/

11:00
How to Improve Awareness, Treatment, and Control of Hypertension in Africa, and How to Reduce Its Consequences. A Call to Action From the World Hypertension League - Gianfranco Parati Daniel T. Lackland Norman R.C. Campbell Mayowa Ojo Owolabi Charlotte Bavuma Hind Mamoun Beheiry Anastase Dzudie Moshen Ibrahim Wafaa El Aroussy Sandhya Singh Cherian V. Varghese Paul K. Whelton Xin-Hua Zhang Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular Neural and Metabolic Sciences; and Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy (G.P.). Division of Translational Neurosciences and Population Studies, Medical University of South Carolina, Charleston (D.T.L.). Department of Medicine, Physiology and Pharmacology and (...) Hypertension

Hypertension, Ahead of Print. Hypertension is the leading preventable risk factor for cardiovascular diseases and disability globally. In low- and middle-income countries hypertension has a major social impact, increasing the disease burden and costs for national health systems. The present (...) (Hypertension)

26 May

Hypertension https://www.ahajournals.org/

11:00
Blood Pressure Control Among US Adults, 2009 to 2012 Through 2017 to 2020 - Paul Muntner Miriam A. Miles Byron C. Jaeger Lonnie Hannon Shakia T. Hardy Yechiam Ostchega Gregory Wozniak Joseph E. Schwartz Department of Epidemiology, University of Alabama at Birmingham. (P.M., S.T.H.) Department of Health Behavior, University of Alabama at Birmingham. (M.A.M., L.H.) Department of Biostatistics, Wake Forest University, Winston Salem, NC (B.C.J.). School of Nursing, Johns Hopkins University, Baltimore, MD (Y.O.). American Medical Association, Chicago, IL (G.W.). Department of Medicine, Columbia University Irving Medical Center, New York, NY (J.E.S.). Department of (...) Hypertension

Hypertension, Ahead of Print. Background:The National Health and Nutrition Examination Survey data indicate that the proportion of US adults with hypertension that had controlled blood pressure (BP) declined from 2013 to 2014 through 2017 to 2018. We analyzed data from National Health and (...) (Hypertension)

24 May

Hypertension https://www.ahajournals.org/

11:00
Effects of Blood Pressure According to Age on End-Stage Renal Disease Development in Patients With Diabetes: A Nationwide Population-Based Cohort Study - Eun Hui Bae Sang Yeob Lim Bongseong Kim Tae Ryom Oh Su Hyun Song Sang Heon Suh Hong Sang Choi Eun Mi Yang Chang Seong Kim Seong Kwon Ma Kyung-Do Han Soo Wan Kim From the Department of Internal Medicine (E.H.B., T.R.O., S. Hyun Song, S. Heon Suh, H.S.C., C.S.K., S.K.M., S.W.K.), Chonnam National University Medical School, Gwangju, Korea. Department of Pediatrics (E.M.Y.), Chonnam National University Medical School, Gwangju, Korea. Department of Internal Medicine, Korea University Ansan Hospital (S.Y.L.). Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1765-1776, August 1, 2022. Background:Recent hypertension guidelines have recommended lower blood pressure (BP) targets in high-risk patients. However, there are no specific guidelines based on age or systolic and diastolic blood pressure (SBP and DBP, (...) (Hypertension)
11:00
Evidence From Human Placenta, Endoplasmic Reticulum–Stressed Trophoblasts, and Transgenic Mice Links Transthyretin Proteinopathy to Preeclampsia - Shibin Cheng Zheping Huang Sayani Banerjee Sukanta Jash Joel N. Buxbaum Surendra Sharma Department of Pediatrics, Women & Infants Hospital, Warren Alpert Medical School of Brown University, Providence, RI (S.C., Z.H., S.B., S.J., S.S.). Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA (J.N.B.). Protego Biopharma, Inc, San Diego, CA (J.N.B.). Hypertension

Hypertension, Volume 79, Issue 8, Page 1738-1754, August 1, 2022. Background:We have demonstrated that protein aggregation plays a pivotal role in the pathophysiology of preeclampsia and identified several aggregated proteins in the circulation of preeclampsia patients, the most prominent of (...) (Hypertension)

23 May

Hypertension https://www.ahajournals.org/

11:00
Markers of Focal and Diffuse Nonischemic Myocardial Fibrosis Are Associated With Adverse Cardiac Remodeling and Prognosis in Patients With Hypertension: The REMODEL Study - Nithin R. Iyer Thu-Thao Le Michelle S.L. Kui Hak-Chiaw Tang Chee-Tang Chin Soon-Kieng Phua Jennifer A. Bryant Chee-Jian Pua Briana Ang Desiree-Faye Toh Tar-Choon Aw Chi-Hang Lee Stuart A. Cook Martin Ugander Calvin W.L. Chin Department of Cardiology, National Heart Centre Singapore (N.R.I., T.-T.L., M.S.L.K., H.-C.T., C.-T.C., J.A.B., S.A.C., C.W.L.C.). National Heart Research Institute Singapore (T.-T.L., J.A.B., C.-J.P., B.A., D.-F.T., S.A.C., C.W.L.C.). Cardiovascular ACP, Duke-NUS Medical School, Singapore (T.-T.L., C.W.L.C.). Department of Laboratory Medicine, Changi General (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1804-1813, August 1, 2022. Background:The prognostic significance of focal and diffuse myocardial fibrosis in patients with cardiovascular risk factors is unclear.Methods:REMODEL (Response of the Myocardium to Hypertrophic Conditions in the Adult (...) (Hypertension)
11:00
Is It Time to Drop Unclassified Category in Pediatric Ambulatory Blood Pressure Monitoring? - J. Fallon Campbell Shweta Shah Poyyapakkam Srivaths Katharine Sigler Alisa A. Acosta Department of Pediatrics, Baylor College of Medicine, Renal Section, Texas Children's Hospital, Houston. Hypertension

Hypertension, Volume 79, Issue 8, Page e125-e126, August 1, 2022. (Hypertension)
11:00
Ambulatory Blood Pressure Monitoring in Children and Adolescents: 2022 Update: A Scientific Statement From the American Heart Association - Joseph T. Flynn Elaine M. Urbina Tammy M. Brady Carissa Baker-Smith Stephen R. Daniels Laura L. Hayman Mark Mitsnefes Andrew Tran Justin P. Zachariah Hypertension

Hypertension, Volume 79, Issue 7, Page e114-e124, July 1, 2022. Use of ambulatory blood pressure monitoring in children and adolescents has markedly increased since publication of the last American Heart Association scientific statement on pediatric ambulatory blood pressure monitoring in 2014. (...) (Hypertension)

19 May

Hypertension https://www.ahajournals.org/

11:01
Reshaping the Preterm Heart: Shifting Cardiac Renin-Angiotensin System Towards Cardioprotection in Rats Exposed to Neonatal High-Oxygen Stress - Mariane Bertagnolli Daniela R. Dartora Pablo Lamata Ernesto Zacur Thuy-An Mai-Vo Ying He Léonie Beauchamp Adam J. Lewandowski Anik Cloutier Megan R. Sutherland Robson A.S. Santos Anne Monique Nuyt Sainte-Justine University Hospital Research Center, Université de Montréal, Canada (M.B., D.R.D., T.-A.M.-V., Y.H., L.B., A.C., M.R.S., A.M.N.). Research Center of the Hospital Sacré-Coeur, CIUSSS Nord-de-l’Île-de-Montréal, Canada (M.B.). School of Physical and Occupational Therapy, Faculty of Medicine, McGill University, Montréal, Canada (M.B.). Instituto de Cardiologia de Porto Alegre, Fundação (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1789-1803, August 1, 2022. Background:Approximately 10% of infants are born preterm. Preterm birth leads to short and long-term changes in cardiac shape and function. By using a rat model of neonatal high-oxygen (80%O2) exposure, mimicking the premature (...) (Hypertension)
11:00
Puberty Timing and Sex-Specific Trajectories of Systolic Blood Pressure: a Prospective Cohort Study - Kate N. O’Neill Joshua A. Bell George Davey Smith Kate Tilling Patricia M. Kearney Linda M. O’Keeffe School of Public Health, University College Cork, Ireland (K.N.O.N., P.M.K., L.M.O.K.). MRC Integrative Epidemiology Unit at the University of Bristol, United Kingdom (J.A.B., G.D.S., K.T., L.M.O.K.). Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom (J.A.B., G.D.S., K.T., L.M.O.K.). Hypertension

Hypertension, Volume 79, Issue 8, Page 1755-1764, August 1, 2022. Background:Sex differences in systolic blood pressure (SBP) emerge during adolescence but the role of puberty is not well understood. We examined sex-specific changes in SBP preceding and following puberty and examined the impact (...) (Hypertension)

18 May

Hypertension https://www.ahajournals.org/

11:00
Cardiac Structure and Function Across the Spectrum of Aldosteronism: the Atherosclerosis Risk in Communities Study - Jenifer M. Brown Magnus O. Wijkman Brian L. Claggett Amil M. Shah Christie M. Ballantyne Josef Coresh Morgan E. Grams Zhiying Wang Bing Yu Eric Boerwinkle Anand Vaidya Scott D. Solomon Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA. (J.M.B., M.O.W., B.L.C., A.M.S., S.D.S.) Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension (A.V.) Departments of Internal Medicine and Health, Medicine and Caring Sciences, Linköping University, Norrköping, Sweden (M.O.W.). Center for Cardiometabolic Disease Prevention, Baylor College of Medicine, (...) Hypertension

Hypertension, Ahead of Print. Background:Aldosterone production and mineralocorticoid receptor activation are implicated in myocardial fibrosis and cardiovascular events.Methods:Cardiac structure and function were assessed in 4547 participants without prevalent heart failure (HF) in the ARIC (...) (Hypertension)
11:00
Evolving Concepts in Endothelial Pathobiology of Pulmonary Arterial Hypertension - Nicholas D. Cober M. Martin VandenBroek Mark L. Ormiston Duncan J. Stewart Ottawa Hospital Research Institute, ON, Canada (N.D.C., D.J.S.). Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, ON, Canada (N.D.C., D.J.S.). Department of Medicine, Queen’s University, Kingston, ON, Canada (M.M.V., M.L.O.). Departments of Surgery, and Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada (M.L.O.). Hypertension

Hypertension, Volume 79, Issue 8, Page 1580-1590, August 1, 2022. Pulmonary arterial hypertension (PAH) is a deadly disease, characterized by increased vascular resistance, pulmonary arteriolar loss, and occlusive arterial remodeling, leading to eventual right heart failure. Evidence (...) (Hypertension)
11:01
Twenty-Four-Hour Pulsatile Hemodynamics Predict Brachial Blood Pressure Response to Renal Denervation in the SPYRAL HTN-OFF MED Trial - Thomas Weber Siegfried Wassertheurer Christopher C. Mayer Bernhard Hametner Kathrin Danninger Raymond R. Townsend Felix Mahfoud Kazuomi Kario Martin Fahy Vanessa DeBruin Nicole Peterson Manuela Negoita Michael A. Weber David E. Kandzari Roland E. Schmieder Konstantinos P. Tsioufis Ronald K. Binder Michael Böhm Cardiology Department, Klinikum Wels-Grieskirchen, Austria (T.W., K.D., R.K.B.). AIT - Austrian Institute of Technology, Vienna, Austria (S.W., C.C.M., B.H.). Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.R.T.). Klinik für Innere Medizin III, (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1506-1514, July 1, 2022. Background:Renal denervation (RDN) lowers blood pressure (BP), but BP response is variable in individual patients. We investigated whether measures of pulsatile hemodynamics, obtained during 24-hour ambulatory BP monitoring, (...) (Hypertension)

17 May

Hypertension https://www.ahajournals.org/

11:00
Global Impact of Different Blood Pressure Thresholds in 4 021 690 Participants of the May Measurement Month Initiative - Janis M. Nolde Thomas Beaney Revathy Carnagarin Aletta E. Schutte Neil R. Poulter Markus P. Schlaich Dobney Hypertension Centre, Medical School–Royal Perth Hospital Unit/RPH Research Foundation, University of Western Australia, Australia (J.M.N., R.C., M.P.S.). Imperial Clinical Trials Unit, Imperial College London, United Kingdom (T.B., N.R.P.). School of Population Health, University of New South Wales, Sydney, Australia (A.E.S.). George Institute for Global Health, Sydney, NSW, Australia (A.E.S.). Hypertension in Africa Research Team, Medical Research Council Unit for Hypertension and (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1497-1505, July 1, 2022. Background:Influential guidelines currently define hypertension at different thresholds of blood pressure (BP). The global May Measurement Month initiative provides a unique opportunity to estimate the potential consequences of (...) (Hypertension)

16 May

Hypertension https://www.ahajournals.org/

11:00
Inverse Association of Skin Temperature With Ambulatory Blood Pressure and the Mediation of Skin Temperature in Blood Pressure Responses to Ambient Temperature - Yoshiaki Tai Kenji Obayashi Yuki Yamagami Keigo Saeki Department of Epidemiology, Nara Medical University School of Medicine, Japan. Hypertension

Hypertension, Volume 79, Issue 8, Page 1845-1855, August 1, 2022. Background:The inverse association between ambient temperature and blood pressure (BP) has been investigated in the context of excess cardiovascular mortality in winter. However, the role of skin temperature (ST), which reflects (...) (Hypertension)
11:00
Hypertension, Arterial Stiffness, and Diabetes: a Prospective Cohort Study - Xue Tian Yingting Zuo Shuohua Chen Yijun Zhang Xiaoli Zhang Qin Xu Shouling Wu Anxin Wang Department of Neurology (X.T., Y.Z., Y.Z., X.Z., Q.X., A.W.), Beijing Tiantan Hospital, Capital Medical University, China. China National Clinical Research Center for Neurological Diseases (X.T., Y.Z., Y.Z., X.Z., Q.X., A.W.), Beijing Tiantan Hospital, Capital Medical University, China. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (X.T., Y.Z.). Beijing Municipal Key Laboratory of Clinical Epidemiology, China (X.T., Y.Z.). (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1487-1496, July 1, 2022. Background:Whether the combination of different blood pressure and arterial stiffness (AS) status is independently associated with diabetes has not been fully investigated so far. This study aimed at investigating the status of (...) (Hypertension)

13 May

Hypertension https://www.ahajournals.org/

06:00
Sex-Related Signaling of Aldosterone/Mineralocorticoid Receptor Pathway in Calcific Aortic Stenosis - Lara Matilla Eva Jover Mattie Garaikoetxea Ernesto Martín-Nuñez Vanessa Arrieta Amaia García-Peña Adela Navarro Amaya Fernández-Celis Alicia Gainza Virginia Álvarez Diego Álvarez de la Rosa Rafael Sádaba Frederic Jaisser Natalia López-Andrés Cardiovascular Translational Research, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain (L.M., E.J., M.G., E.M.-N., V.A., A.G.-P., A.N., A.F.-C., A.G., V.A., R.S., N.L.-A.). Department of Physiology, Institute of Biomedical Technology, University of Laguna, La Laguna, Spain (D.A.d.l.R.). (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1724-1737, August 1, 2022. Background:There are sex differences in the pathophysiology of aortic valve (AV) calcification in patients with aortic stenosis, although the molecular and cellular mechanisms have not been elucidated. Aldosterone (Aldo) promotes (...) (Hypertension)

12 May

Hypertension https://www.ahajournals.org/

11:00
Performance of a Multianalyte ‘Rule-Out’ Assay in Pregnant Individuals With Suspected Preeclampsia - Maged M. Costantine Baha Sibai Allan T. Bombard Mark Sarno Holly West David M. Haas Alan T. Tita Michael J. Paidas Erin A.S. Clark Kim Boggess Chad Grotegut William Grobman Emily J Su Irina Burd George Saade Martin R. Chavez Michael J. Paglia Audrey Merriam Carlos Torres Mounira Habli Georges Macones Tony Wen James Bofill Anna Palatnik Rodney K. Edwards Sina Haeri Pankaj Oberoi Amin Mazloom Matthew Cooper Steven Lockton Gary D. Hankins Departments of Obstetrics and Gynecology of The Ohio State University, Columbus (M.M.C). The University of Texas Health Sciences Houston (B.S). NVB (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1515-1524, July 1, 2022. Background:The ability to diagnose preeclampsia clinically is suboptimal. Our objective was to validate a novel multianalyte assay and characterize its performance, when intended for use as an aid to rule-out (...) (Hypertension)
11:00
Sex Differences in Diurnal Sodium Handling During Diet-Induced Obesity in Rats - Reham H. Soliman Chunhua Jin Crystal M. Taylor Emile Moura Coelho da Silva David M. Pollock Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham. Hypertension

Hypertension, Volume 79, Issue 7, Page 1395-1408, July 1, 2022. Background:Emerging evidence over the past several years suggests that diurnal control of sodium excretion is sex dependent and involves the renal endothelin system. Given recent awareness of disruptions of circadian function in (...) (Hypertension)
11:00
The Immune System in Hypertension: a Lost Shaker of Salt 2021 Lewis K. Dahl Memorial Lecture - Xiaohan Lu Steven D. Crowley Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, NC. Hypertension

Hypertension, Volume 79, Issue 7, Page 1339-1347, July 1, 2022. The seminal observations of Dr Lewis Dahl regarding renal mechanisms of hypertension remain highly relevant in light of more recent experiments showing that immune system dysfunction contributes to hypertension pathogenesis. Dr (...) (Hypertension)

11 May

Hypertension https://www.ahajournals.org/

06:00
Identification of a Gut Commensal That Compromises the Blood Pressure-Lowering Effect of Ester Angiotensin-Converting Enzyme Inhibitors - Tao Yang Xue Mei Ethel Tackie-Yarboi Millicent Tambari Akere Jun Kyoung Blair Mell Ji-Youn Yeo Xi Cheng Jasenka Zubcevic Elaine M. Richards Carl J. Pepine Mohan K. Raizada Isaac T. Schiefer Bina Joe Department of Physiology and Pharmacology, College of Medicine and Life Sciences (T.Y., X.M., J.K., B.M., J.-Y.Y., X.C., J.Z., B.J.), University of Toledo, OH. UT Microbiome Consortium, Center for Hypertension and Precision Medicine (T.Y., X.M., B.M., J.-Y.Y., X.C., J.Z., B.J.), University of Toledo, OH. Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1591-1601, August 1, 2022. Background:Despite the availability of various classes of antihypertensive medications, a large proportion of hypertensive individuals remain resistant to treatments. The reason for what contributes to low efficacy of (...) (Hypertension)
11:00
Disintegrin and Metalloproteinases (ADAMs [A Disintegrin and Metalloproteinase] and ADAMTSs [ADAMs With a Thrombospondin Motif]) in Aortic Aneurysm - Tolga Kilic Keisuke Okuno Satoru Eguchi Zamaneh Kassiri Department of Physiology, Cardiovascular Research Center, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada (T.K., Z.K.). Cardiovascular Research Center and Department of Cardiovascular Science, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (K.O., S.E.). Hypertension

Hypertension, Volume 79, Issue 7, Page 1327-1338, July 1, 2022. Aortic aneurysm is a complex pathology that can be lethal if not detected in time. Although several molecular mechanisms and pathways have been identified to be involved in aortic aneurysm development and growth, the current lack (...) (Hypertension)
08:00
Carotid Intima-Media Thickness Is Associated With Obesity and Hypertension in Young People - Angela K. Lucas-Herald Christian Delles Developmental Endocrinology Research Group, School of Medicine, Dentistry and Nursing, University of Glasgow (A.K.L.-H.), University of Glasgow, United Kingdom. Institute of Cardiovascular and Medical Sciences, British Heart Foundation Centre for Research Excellence (A.K.L.-H., C.D.), University of Glasgow, United Kingdom. Hypertension

Hypertension, Volume 79, Issue 6, Page 1177-1179, June 1, 2022. (Hypertension)
08:00
Correction to: Inverse Association Between Riboflavin Intake and New-Onset Hypertension: A Nationwide Cohort Study in China Hypertension

Hypertension, Volume 79, Issue 6, Page e110-e110, June 1, 2022. (Hypertension)
08:00
Correction to: Occupational Physical Activity and New-Onset Hypertension: A Nationwide Cohort Study in China Hypertension

Hypertension, Volume 79, Issue 6, Page e109-e109, June 1, 2022. (Hypertension)

10 May

Hypertension https://www.ahajournals.org/

11:00
Separate and Joint Associations of Cardiorespiratory Fitness and Healthy Vascular Aging With Subclinical Atherosclerosis in Men - Sae Young Jae Kyung Hyun Lee Hyun Jeong Kim Setor K. Kunutsor Kevin S. Heffernan Rachel E. Climie Kanokwan Bunsawat Mira Kang Department of Sport Science (S.Y.J., H.J.K.), University of Seoul, Republic of Korea. Division of Urban Social Health, Graduate School of Urban Public Health (S.Y.J.), University of Seoul, Republic of Korea. Department of Digital Health, SAIHST, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (K.H.L., M.K.). National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1445-1454, July 1, 2022. Background:Achieving healthy vascular aging (HVA) is important for decelerating age-related cardiovascular disease risk. We evaluated the interplay between HVA, cardiorespiratory fitness (CRF), and subclinical (...) (Hypertension)
11:00
Differences in Regulation of Cortisol Secretion Contribute to Left Ventricular Abnormalities in Patients With Essential Hypertension - Gabriele Brosolo Cristiana Catena Andrea Da Porto Luca Bulfone Antonio Vacca Nicolas D. Verheyen Leonardo A. Sechi Hypertension Unit, Division of Internal Medicine, Department of Medicine, University of Udine, Udine, Italy (G.B., C.C., A.D.P., L.B., A.V., L.A.S.). Department of Cardiology, Medical University of Graz, Austria (N.D.V.). Hypertension

Hypertension, Volume 79, Issue 7, Page 1435-1444, July 1, 2022. Background:Left ventricular (LV) abnormalities were reported in patients with overt and subclinical Cushing syndrome. The aim of this study was to investigate the relationships of daily plasma cortisol profile and cortisol response (...) (Hypertension)
06:00
Chronic Hypoxia in Ovine Pregnancy Recapitulates Physiological and Molecular Markers of Preeclampsia in the Mother, Placenta, and Offspring - Wen Tong Beth J. Allison Kirsty L. Brain Olga V. Patey Youguo Niu Kimberley J. Botting Sage G. Ford Tessa A. Garrud Peter F.B. Wooding Caroline J. Shaw Qiang Lyu Lin Zhang Jin Ma Tereza Cindrova-Davies Hong Wa Yung Graham J. Burton Dino A. Giussani Department of Physiology Development & Neuroscience, University of Cambridge, United Kingdom (W.T., B.J.A., K.L.B., O.V.P., Y.N., K.J.B., S.G.F., T.A.G., P.F.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.). Centre for Trophoblast Research, University of Cambridge, United Kingdom (W.T., Y.N., K.J.B., T.A.G., P.G.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.). (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1525-1535, July 1, 2022. Background:Preeclampsia continues to be a prevalent pregnancy complication and underlying mechanisms remain controversial. A common feature of preeclampsia is utero-placenta hypoxia. In contrast to the impact of hypoxia on the (...) (Hypertension)
06:00
Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic Peptide - Takeshi Tokudome Kentaro Otani Yuanjie Mao Lars Jørn Jensen Yuji Arai Takahiro Miyazaki Takashi Sonobe James T. Pearson Tsukasa Osaki Naoto Minamino Junji Ishida Akiyoshi Fukamizu Hayato Kawakami Daisuke Onozuka Kunihiro Nishimura Mikiya Miyazato Hirohito Nishimura Department of Biochemistry (T.T., Y.M., N.M., M.M., H.N.), National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan. Department of Regenerative Medicine and Tissue Engineering (K.O.), National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan. Department of Research Promotion and Management (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1409-1422, July 1, 2022. Background:ANP (atrial natriuretic peptide), acting through NPR1 (natriuretic peptide receptor 1), provokes hypotension. Such hypotension is thought to be due to ANP inducing vasodilation via NPR1 in the vasculature; however, the (...) (Hypertension)

5 May

Hypertension https://www.ahajournals.org/

11:00
Epithelial Sodium Channel ? Subunit Is Expressed in Human Arteries and Has Potential Association With Hypertension - Puja Paudel Isabelle van Hout Richard W. Bunton Dominic J. Parry Sean Coffey Fiona J. McDonald Martin Fronius Department of Physiology, School of Biomedical Sciences (P.P., I.v.H., F.J.M., M.F.), University of Otago, Dunedin, New Zealand. HeartOtago (P.P., I.v.H., S.C., M.F.), University of Otago, Dunedin, New Zealand. Department of Medicine, Otago Medical School (S.C.), University of Otago, Dunedin, New Zealand. Department of Cardiothoracic Surgery, Otago Medical School, Dunedin Hospital, New Zealand (R.W.B., (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1385-1394, July 1, 2022. Background:Elevated expression and increased activity of vascular epithelial sodium channel (ENaC) can result in vascular dysfunction in small animal models. However, there is limited or no knowledge on expression and function of (...) (Hypertension)
11:00
Midgestation Leptin Infusion Induces Characteristics of Clinical Preeclampsia in Mice, Which Is Ablated by Endothelial Mineralocorticoid Receptor Deletion - Jessica L. Faulkner Derrian Wright Galina Antonova Iris Z. Jaffe Simone Kennard Eric J. Belin de Chantemèle Department of Physiology (J.L.F.), Medical College of Georgia at Augusta University. Vascular Biology Center (D.W., G.A., S.K., E.J.B.d.C.), Medical College of Georgia at Augusta University. Department of Cardiology (E.J.B.d.C.), Medical College of Georgia at Augusta University. Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1536-1547, July 1, 2022. Background:Patients with preeclampsia demonstrate increases in placental leptin production in midgestation, and an associated increase in late gestation plasma leptin levels. The consequences of mid-late gestation increases in (...) (Hypertension)

4 May

Hypertension https://www.ahajournals.org/

11:00
Mineralocorticoid Receptor Antagonists Cause Natriuresis in the Absence of Aldosterone - Yujiro Maeoka Xiao-Tong Su Wen-Hui Wang Xin-Peng Duan Avika Sharma Na Li Olivier Staub James A. McCormick David H. Ellison Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland (Y.M., X.-T.S., A.S., J.A.M., D.H.E.). Department of Pharmacology, New York Medical College, Valhalla (W.-H.W., X.-P.D.). Department of Pharmacology and Toxicology, University of Lausanne, Switzerland (N.L., O.S.). LeDucq Transatlantic Network of Excellence (O.S., D.H.E.). Veterans Affairs Portland Healthcare System, Portland, OR (D.H.E.). Oregon Clinical (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1423-1434, July 1, 2022. Background:MR (mineralocorticoid receptor) antagonists are recommended for patients with resistant hypertension even when circulating aldosterone levels are not high. Although aldosterone activates MR to increase epithelial sodium (...) (Hypertension)
11:00
Abnormal Cyclic Nucleotide Signaling at the Outer Mitochondrial Membrane In Sympathetic Neurons During the Early Stages of Hypertension - Dan Li Kun Liu Harvey Davis Calum Robertson Oliver C. Neely Adib Tarafdar Ni Li Konstantinos Lefkimmiatis Manuela Zaccolo David J. Paterson Burdon Sanderson Cardiac Science Centre and BHF Centre of Research Excellence, Department of Physiology, Anatomy and Genetics (D.L., K.L., H.D., C.R., O.C.N., A.T., N.L., M.Z., D.J.P.), University of Oxford, United Kingdom. Chinese Academy of Medical Sciences Oxford Institute (COI), Nuffield Department of Medicine Research Building (N.L.), University of Oxford, United Kingdom. Department of Neuroscience, Physiology and Pharmacology, University College (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1374-1384, July 1, 2022. Background:Disruption of cyclic nucleotide signaling in sympathetic postganglionic neurons contributes to impaired intracellular calcium handling (Ca2+) and the development of dysautonomia during the early stages of hypertension, (...) (Hypertension)

3 May

Hypertension https://www.ahajournals.org/

11:01
Day to Day Blood Pressure Variability Associated With Cerebral Arterial Dilation and White Matter Hyperintensity - Boyu Zhang Yajing Huo Zidong Yang Huihui Lv Yilin Wang Jianfeng Feng Yan Han He Wang Institute of Science and Technology for Brain-Inspired Intelligence (B.Z., Z.Y., J.F., H.W.), Fudan University, Shanghai, China. Department of Neurology, Zhongshan Hospital (H.W.), Fudan University, Shanghai, China. Human Phenome Institute (H.W.), Fudan University, Shanghai, China. Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, China (B.Z., Z.Y., J.F., H.W.). Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1455-1465, July 1, 2022. Background:Previous studies suggested blood pressure variability (BPV) might help reveal interactions between blood pressure fluctuation and white matter lesions, and the impact of elevated BPV on white matter hyperintensity (WMH) (...) (Hypertension)
11:00
Role of Antihypertensive Treatment and Blood Pressure Control in the Occurrence of Adverse Pregnancy Outcomes: a Population-Based Study of Linked Electronic Health Records - Sukainah Al Khalaf Ali S. Khashan Lucy C. Chappell Éilis J. O’Reilly Fergus P. McCarthy School of Public Health (S.A.K., A.S.K., E.J.O.), University College Cork, Ireland. INFANT Research Centre (S.A.K., A.S.K., F.P.M.), University College Cork, Ireland. Department of Women and Children’s Health, King’s College London (L.C.C.). Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (E.J.O.). Environmental Research Institute, University College Cork, Ireland (E.J.O.). Environmental Research Institute, University College Cork, Ireland (E.J.O.). Department of Obstetrics (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1548-1558, July 1, 2022. Background:Chronic hypertension (CH) adversely impacts pregnancy. It remains unclear whether antihypertensive treatment alters these risks. We examined the role of antihypertensive treatment in the association between CH and (...) (Hypertension)
11:00
Association Between Hypertension and Incident Infective Endocarditis - Gyu Bae Lee Koh Eun Shin Kyungdo Han Ho-Sung Son Jae-Seung Jung Yang-Hyun Kim Hee-Jung Kim Department of Family Medicine, Korea University Anam Hospital, Korea University, Seoul (G.B.L., K.E.S., Y.-H.K.). Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea (K.H.). Department of Thoracic and Cardiovascular Surgery, Korea University Anam Hospital, Korea University (H.-S.S., J.-S.J., H.-J.K.). Hypertension

Hypertension, Volume 79, Issue 7, Page 1466-1474, July 1, 2022. Background:This study aimed to evaluate the association of hypertension with incident infective endocarditis (IE) by investigating the incidence of IE according to blood pressure levels using the National Health Insurance Service (...) (Hypertension)

28 April

Hypertension https://www.ahajournals.org/

11:00
Calcium Sensing Receptor Variants Increase Pulmonary Hypertension Susceptibility - Bingxun Liu Yun-Peng Wei Xiaohang Fan Xiaoyi Hu Zeshuai Chen Xiaoyuan Liu Yan Xu Lu Wang Tao Wang Matthieu Ruiz Jocelyn Dupuis Ping Yuan Jinming Liu Songling Huang Liping Zhu Zhi-Cheng Jing Qinghua Hu Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China (B.L., X.F., Z.C., X.L.,Y.X., L.Z., Q.H.). Key Laboratory of Pulmonary Diseases of Ministry of Health, Tongji Medical College, HUST, Wuhan, China (B.X., X.F., X.H., Z.C., X.L., Y.X., L.W., T.W., L.Z., Q.H.). Department of Cardiology, State Key (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1348-1360, July 1, 2022. Background:Pulmonary arterial hypertension is an incurable disease, in which the extracellular CaSR (calcium sensing receptor) is mechanistically important. This study was aimed to genetically link theCaSRgene and function to the (...) (Hypertension)
11:00
DPP4 Promotes Human Endothelial Cell Senescence and Dysfunction via the PAR2–COX-2–TP Axis and NLRP3 Inflammasome Activation - Inés Valencia Susana Vallejo Pilar Dongil Alejandra Romero Álvaro San Hipólito-Luengo Licia Shamoon María Posada Damián García-Olmo Raffaelle Carraro Jorge D. Erusalimsky Tania Romacho Concepción Peiró Carlos F. Sánchez-Ferrer Department of Pharmacology and Therapeutics, School of Medicine (I.V., S.V., P.D., A.R., Á.S.H.-L., L.S., T.R., C.P., C.F.S.-F.), Universidad Autónoma de Madrid, Spain. PhD Programme in Pharmacology and Physiology, Doctoral School (I.V., L.S.), Universidad Autónoma de Madrid, Spain. Department of Medicine, School of Medicine (R.C.), Universidad Autónoma de Madrid, Spain. (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1361-1373, July 1, 2022. Background:Abnormal accumulation of senescent cells in the vessel wall leads to a compromised vascular function contributing to vascular aging. Soluble DPP4 (dipeptidyl peptidase 4; sDPP4) secretion from visceral adipose tissue is (...) (Hypertension)

26 April

Hypertension https://www.ahajournals.org/

11:00
Lipidomic Signatures of Dairy Consumption and Associated Changes in Blood Pressure and Other Cardiovascular Risk Factors Among Chinese Adults - Huan Yun Liang Sun Qingqing Wu Yaogan Luo Qibin Qi Huaixing Li Weiqiong Gu Jiqiu Wang Guang Ning Rong Zeng Geng Zong Xu Lin Shanghai Institute of Nutrition and Health (H.Y., L.S., Y.L., H.L., G.Z., X.L.), University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. Key Laboratory of Systems Biology, Hangzhou Institute for Advanced Study (R.Z., X.L.), University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. Key Laboratory of Systems Health Science of Zhejiang Province, Hangzhou Institute for Advanced Study (R.Z., X.L.), University (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1617-1628, August 1, 2022. Background:Omics data may provide a unique opportunity to discover dairy-related biomarkers and their linked cardiovascular health.Methods:Dairy-related lipidomic signatures were discovered in baseline data from a Chinese cohort (...) (Hypertension)

25 April

Hypertension https://www.ahajournals.org/

11:01
Jeremiah Stamler, MD (1919–2022) - Philip Greenland Linda V. Van Horn Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL. Hypertension

Hypertension, Volume 79, Issue 7, Page e111-e112, July 1, 2022. (Hypertension)
11:00
Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: a Review of Shared Cardiometabolic Risk Factors - Emir Muzurovi? Carol Chiung-Hui Peng Matthew J. Belanger Despina Sanoudou Dimitri P. Mikhailidis Christos S. Mantzoros Department of Internal Medicine, Endocrinology Section, Clinical Centre of Montenegro, Podgorica (E.M.). Faculty of Medicine, University of Montenegro, Podgorica, Montenegro (E.M.). Section of Endocrinology, Diabetes, Nutrition & Weight Management, Boston University School of Medicine, Boston, MA (C.C.-H.P.). Northeast Medical Group, Yale New Haven Health, New Haven, CT (M.J.B.). Clinical Genomics and Pharmacogenomics Unit, 4th Department of Internal Medicine, Attikon (...) Hypertension

Hypertension, Volume 79, Issue 7, Page 1319-1326, July 1, 2022. The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising. NAFLD/nonalcoholic steatohepatitis (NASH) is associated not only with hepatic morbidity and mortality but also with an increased cardiovascular risk. NAFLD and (...) (Hypertension)

19 April

Hypertension https://www.ahajournals.org/

11:00
Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal Pulmonary Hypertension in High-Altitude Populations - Alexandra Heath-Freudenthal Lilian Toledo-Jaldin Inge von Alvensleben Litzi Lazo-Vega Rodrigo Mizutani Margaret Stalker Hussna Yasini Fanny Mendizabal Jesus Dorado Madera William Mundo Melany Castro-Monrroy Julie A. Houck Any Moreno-Aramayo Valquiria Miranda-Garrido Emily J. Su Dino A. Giussani Steven H. Abman Lorna G. Moore Colleen G. Julian Kardiozentrum, La Paz, Bolivia (A.H.-F., I.v.A., F.M.). Hospital Materno-Infantil, La Paz, Bolivia (L.T.J., L.L.V., R.M., A.M.-A., V.M.-G.). University of Colorado School of Medicine, Aurora, Colorado (M.S., W.M.). College of Liberal Arts and (...) Hypertension

Hypertension, Volume 79, Issue 6, Page 1286-1296, June 1, 2022. Background:Preeclampsia and fetal growth restriction increase cardiopulmonary disease risk for affected offspring and occur more frequently at high-altitude (?2500 m). Retrospective studies indicate that birth to a preeclampsia (...) (Hypertension)

18 April

Hypertension https://www.ahajournals.org/

11:00
Type 1 Angiotensin Receptors on CD11c-Expressing Cells Protect Against Hypertension by Regulating Dendritic Cell–Mediated T Cell Activation - Xiaohan Lu Jiandong Zhang Yi Wen Jiafa Ren Robert Griffiths Nathan P. Rudemiller Shintaro Ide Tomokazu Souma Steven D. Crowley Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, NC (X.L., Y.W., J.R., R.G., N.P.R., S.I., T.S., S,D.C.). Division of Cardiology, Department of Medicine, University of North Carolina at Chapel Hill (J.Z.). Hypertension

Hypertension, Volume 79, Issue 6, Page 1227-1236, June 1, 2022. Background:Type 1 angiotensin (AT1) receptors are expressed on immune cells, and we previously found that bone marrow–derived AT1receptors protect against Ang (angiotensin) II-induced hypertension. CD11c is expressed on myeloid (...) (Hypertension)

13 April

Hypertension https://www.ahajournals.org/

08:00
PKG, CXL, and HNO. Relax! - Katrin Schröder Institute of Cardiovascular Physiology, Vascular Research Center, Faculty of Medicine, Goethe-University, Germany. Hypertension

Hypertension, Volume 79, Issue 5, Page 957-959, May 1, 2022. (Hypertension)

6 April

Hypertension https://www.ahajournals.org/

11:00
Aortic Body Chemoreceptors Regulate Coronary Blood Flow in Conscious Control and Hypertensive Sheep - Dylan Pen Julia Shanks Carolyn Barrett Yonis Abukar Julian F.R. Paton Rohit Ramchandra Manaaki Manawa – The Centre for Heart Research and the Department of Physiology, University of Auckland, New Zealand. Hypertension

Hypertension, Volume 79, Issue 6, Page 1275-1285, June 1, 2022. Background:Peripheral arterial chemoreceptors monitor the chemical composition of arterial blood and include both the carotid and aortic bodies (ABs). While the role of the carotid bodies has been extensively studied, the (...) (Hypertension)

5 April

Hypertension https://www.ahajournals.org/

11:00
Improved Diagnostic Accuracy of Clonidine Suppression Testing Using an Age-Related Cutoff for Plasma Normetanephrine - Hanna Remde Christina Pamporaki Marcus Quinkler Svenja Nölting Aleksander Prejbisz Henri J.L.M. Timmers Jimmy Masjkur Carmina T. Fuss Martin Fassnacht Graeme Eisenhofer Timo Deutschbein Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, Germany (H.R., C.T.F., M.F., T.D.). Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany (C.P., J.M., G.E.). Endocrinology in Charlottenburg, Berlin, Germany (M.Q.). Department of Endocrinology, Diabetology and Clinical Nutrition, (...) Hypertension

Hypertension, Volume 79, Issue 6, Page 1257-1264, June 1, 2022. Background:Moderately elevated plasma normetanephrine (NMN) levels are frequent among patients with suspected pheochromocytoma and paraganglioma (PPGL). Clonidine suppression testing (CST) is recommended to distinguish patients (...) (Hypertension)
11:00
Individualized Beta-Blocker Treatment for High Blood Pressure Dictated by Medical Comorbidities: Indications Beyond the 2018 European Society of Cardiology/European Society of Hypertension Guidelines - Giuseppe Mancia Sverre E. Kjeldsen Reinhold Kreutz Atul Pathak Guido Grassi Murray Esler University of Milano-Bicocca, Milan, Italy (G.M., G.G.). Department of Cardiology, University of Oslo, Ullevaal Hospital, Norway (S.E.K.). Charité – Universitätsmedizin Berlin, Institute of Clinical Pharmacology and Toxicology, Germany (R.K.). Department of Cardiology, Centre Hospitalier Princesse Grace, Monte Carlo, Monaco (A.P.). Human Neurotransmitters Laboratory, Baker Heart and Diabetes Institute, and Monash University, Melbourne, Australia (...) Hypertension

Hypertension, Volume 79, Issue 6, Page 1153-1166, June 1, 2022. Several hypertension guidelines have removed beta-blockers from their previous position as first-choice drugs for the treatment of hypertension. However, this downgrading may not be justified by available evidence because (...) (Hypertension)

4 April

Hypertension https://www.ahajournals.org/

11:00
Association of Polygenic Risk Score With Blood Pressure and Adverse Cardiovascular Outcomes in Individuals With Type II Diabetes: Insights From the ACCORD Trial - Vibhu Parcha Akhil Pampana Adam P. Bress Marguerite R. Irvin Garima Arora Pankaj Arora Division of Cardiovascular Disease (V.P., A.P., G.A., P.A.) Department of Epidemiology, School of Public Health (M.R.I.), University of Alabama at Birmingham. Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City (A.B.). Section of Cardiology, Birmingham Veterans Affairs Medical Center, AL (P.A.). Hypertension

Hypertension, Volume 79, Issue 5, Page e100-e102, May 1, 2022. (Hypertension)

1 April

Hypertension https://www.ahajournals.org/

11:00
Associations of Long-Term Visit-to-Visit Blood Pressure Variability With Subclinical Kidney Damage and Albuminuria in Adulthood: a 30-Year Prospective Cohort Study - Yang Wang Peng Zhao Chao Chu Ming-Fei Du Xiao-Yu Zhang Ting Zou Gui-Lin Hu Hao-Wei Zhou Hao Jia Yue-Yuan Liao Chen Chen Qiong Ma Dan Wang Yu Yan Yue Sun Ke-Ke Wang Ze-Jiaxin Niu Xi Zhang Zi-Yue Man Yong-Xing Wu Lan Wang Hui-Xian Li Jie Zhang Chun-Hua Li Wei-Hua Gao Ke Gao Wan-Hong Lu Gary V. Desir Christian Delles Fang-Yao Chen Jian-Jun Mu Department of Cardiovascular Medicine (Y.W., C. Chu, M.-F.D., T.Z., G.-L.H., H.-W.Z., H.J., Y.-Y.L., C. Chen, Q.M., D.W., Y.Y., Y.S., K.-K.W., Z.-J.N., X.Z., Z.-Y.M., K.G., J.-J.M.), Department of Critical Care Medicine (Y.-X.W.), First Affiliated (...) Hypertension

Hypertension, Volume 79, Issue 6, Page 1247-1256, June 1, 2022. Background:Recent evidence indicates that long-term visit-to-visit blood pressure variability (BPV) may be associated with risk of cardiovascular disease. We, therefore, aimed to determine the potential associations of long-term (...) (Hypertension)

31 March

Hypertension https://www.ahajournals.org/

11:00
DP1 (Prostaglandin D2 Receptor 1) Activation Protects Against Vascular Remodeling and Vascular Smooth Muscle Cell Transition to Myofibroblasts in Angiotensin II–Induced Hypertension in Mice - Fangdi Zou Yong Li Shijie Zhang Jian Zhang Department of Pharmacology, School of Basic Medical Sciences (F.Z., Y.L., S.Z., J.Z.), Tianjin Medical University, China. School of Pharmacy (F.Z.), Tianjin Medical University, China. School of Pharmacy, East China University of Science and Technology, Shanghai, China (J.Z.). Hypertension

Hypertension, Volume 79, Issue 6, Page 1203-1215, June 1, 2022. Background:Vascular smooth muscle cell (VSMC) phenotype transition plays an essential role in vascular remodeling. PGD2(Prostaglandin D2) is involved in cardiovascular inflammation. In this study, we aimed to investigates the role (...) (Hypertension)
11:00
Loss of Endothelial Cytochrome P450 Reductase Induces Vascular Dysfunction in Mice - Pedro Felipe Malacarne Corina Ratiu Anna Gajos-Draus Niklas Müller Melina Lopez Beatrice Pflüger-Müller Xinxin Ding Timothy Warwick James Oo Mauro Siragusa Carlo Angioni Stefan Günther Andreas Weigert Gerd Geißlinger Dieter Lütjohann Wolf-Hagen Schunck Ingrid Fleming Ralf P. Brandes Flávia Rezende Institute for Cardiovascular Physiology (P.F.M., C.R., A.G.-D., N.M., M.L., B.P.-M., T.W., J.O., R.P.B., F.R.), Goethe-University, Frankfurt, Germany. Institute for Vascular Signalling (M.S., I.F.), Goethe-University, Frankfurt, Germany. Institute for Clinical Pharmacology (C.A., G.G.), (...) Hypertension

Hypertension, Volume 79, Issue 6, Page 1216-1226, June 1, 2022. Background:POR (cytochrome P450 reductase) provides electrons for the catalytic activity of the CYP (cytochrome P450) monooxygenases. CYPs are dual-function enzymes as they generate protective vasoactive mediators derived from (...) (Hypertension)

29 March

Hypertension https://www.ahajournals.org/

11:00
Insights From Matched Office and Ambulatory Blood Pressure in Youth: Clinical Relevance - Empar Lurbe Josep Redon Julio Alvarez Maria Grau-Pérez Fernando Martinez Giuseppe Mancia Pediatric Department, Consorcio Hospital General (E.L., J.A.), University of Valencia, Spain. Cardiovascular and Renal Research Group, INCLIVA Research Institute (J.R., M.G.-P., F.M.), University of Valencia, Spain. Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain (E.L., J.R., J.A.). Internal Medicine Hospital Clínico of Valencia, Spain (F.M.). University of Milano-Bicocca, Italy (...) Hypertension

Hypertension, Volume 79, Issue 6, Page 1237-1246, June 1, 2022. Background:Information on the relationship between ambulatory blood pressure (ABP) and concurrently office blood pressure (BP) values in youth still suffers from limitations. We provide information on the differences between office (...) (Hypertension)

28 March

Hypertension https://www.ahajournals.org/

11:00
Omeprazole Administration in Preterm Preeclampsia: a Randomized Controlled Trial to Study Its Effect on sFlt-1 (Soluble Fms-Like Tyrosine Kinase-1), PlGF (Placental Growth Factor), and ET-1 (Endothelin-1) - Rugina I. Neuman Milan D. Baars Langeza Saleh Michelle Broekhuizen Daan Nieboer Jérôme Cornette Sam Schoenmakers Michel Verhoeven Birgit C.P. Koch Henk Russcher Sjoerd A.A. van den Berg Anton H. van den Meiracker Willy Visser A.H. Jan Danser Department of Internal Medicine, Division of Pharmacology and Vascular Medicine (R.I.N., L.S., M.B., A.H.v.d.M., W.V., A.H.J.D.), Erasmus MC University Medical Center, Rotterdam, The Netherlands. Department of Obstetrics and Gynecology, Division of Obstetrics and Fetal Medicine (R.I.N., M.D.B., L.S., J.C., S.S., W.V.), Erasmus MC University Medical (...) Hypertension

Hypertension, Volume 79, Issue 6, Page 1297-1307, June 1, 2022. Background:Low sFlt-1 (soluble Fms-like tyrosine kinase-1) and ET-1 (endothelin-1) levels have been reported in preeclamptic women using proton pump inhibitors.Methods:Here, we examined whether the proton pump inhibitor omeprazole (...) (Hypertension)

23 March

Hypertension https://www.ahajournals.org/

10:00
Ten-Second Heart Rate Variability, Its Changes Over Time, and the Development of Hypertension - Jeonggyu Kang Yoosoo Chang Yejin Kim Hocheol Shin Seungho Ryu Total Healthcare Center (J.K.), Sungkyunkwan University, Seoul, South Korea. Center for Cohort Studies, Total Healthcare Center (J.K., Y.C., Y.K., H.S., S.R.), Sungkyunkwan University, Seoul, South Korea. Department of Occupational and Environmental Medicine (Y.C., S.R.), Sungkyunkwan University, Seoul, South Korea. Department of Family Medicine (H.S.), Sungkyunkwan University, Seoul, South Korea. Kangbuk Samsung Hospital, School of Medicine and Department of Clinical Research Design and Evaluation, SAIHST (Y.C., S.R.), (...) Hypertension

Hypertension, Volume 79, Issue 6, Page 1308-1318, June 1, 2022. Background:The role of ultrashort-term heart rate variability (HRV) and its temporal changes in incident hypertension are unknown. We aimed to investigate the association between 10-second HRV, its changes, and incident (...) (Hypertension)

18 March

Hypertension https://www.ahajournals.org/

10:00
A Rare Disease Leading to Hypertension - Jing Chen Xin Chen Anna F. Dominiczak Robert M. Carey Cheryl L. Laffer Fernando Elijovich Sandra J. Taler Tanja Dudenbostel Rhian M. Touyz Ji-Guang Wang Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China (J.C., X.C.). BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland, United Kingdom (A.F.D.). Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville (R.M.C.). Division of Clinical Pharmacology, (...) Hypertension

Hypertension, Volume 79, Issue 6, Page 1147-1152, June 1, 2022. (Hypertension)

17 March

Hypertension https://www.ahajournals.org/

09:16
A Message to the Hypertension Community Regarding the Ukraine Crisis - Rhian M. Touyz David G. Harrison Research Institute of the McGill University Health Centre, Department of Medicine, McGill University, Montreal, Canada (R.M.T.). Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (D.G.H.). Hypertension

Hypertension, Volume 79, Issue 6, Page 1145-1146, June 1, 2022. (Hypertension)
10:00
Na+-Retaining Action of COX-2 (Cyclooxygenase-2)/EP1 Pathway in the Collecting Duct via Activation of Intrarenal Renin-Angiotensin-Aldosterone System and Epithelial Sodium Channel - Chuanming Xu Guangrui Yang Ziwei Fu Yanting Chen Shiying Xie Fei Wang Tianxin Yang Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City. Hypertension

Hypertension, Volume 79, Issue 6, Page 1190-1202, June 1, 2022. Background:The collecting duct (CD) is a major site of both biosynthesis and action of prostaglandin E2as highlighted by the predominant expression of COX-2 (cyclooxygenase-2) and some E-prostanoid (EP) subtypes at this nephron (...) (Hypertension)
10:00
Blood Pressure Hyperreactivity to Standing: a Predictor of Adverse Outcome in Young Hypertensive Patients - Paolo Palatini Lucio Mos Francesca Saladini Marcello Rattazzi Department of Medicine, University of Padova, Italy (P.P., F.S., M.R.). San Antonio Hospital, San Daniele del Friuli, Italy (L.M.). Hypertension

Hypertension, Volume 79, Issue 5, Page 984-992, May 1, 2022. The prognostic significance and the mechanisms of blood pressure (BP) hyperreactivity to standing remain controversial. This study aims to evaluate the association of orthostatic hyperreactivity with major adverse cardiovascular and (...) (Hypertension)

16 March

Hypertension https://www.ahajournals.org/

10:01
Cerebrovascular Variants and the Role of the Selfish Brain in Young-Onset Hypertension - Nathan E. Manghat Elizabeth Robinson Konstantina Mitrousi Jonathan C.L. Rodrigues Thomas Hinton Julian F.R. Paton Richard G. Wise Angus K. Nightingale Emma C. Hart Department of Radiology, Bristol Royal Infirmary, University Hospitals Bristol and Weston NHS Foundation Trust, United Kingdom (N.E.M., E.R., K.M.). Cardionomics Research Group, School of Physiology, Pharmacology and Neurosciences, University of Bristol, United Kingdom (N.E.M., K.M., T.H., A.K.N., E.C.H.). Department of Radiology, Royal United Hospitals Bath NHS Foundation Trust (J.C.L.R.). Department of Health, University of (...) Hypertension

Hypertension, Volume 79, Issue 6, Page 1265-1274, June 1, 2022. Background:Variants in the posterior anatomy of the cerebral circulation are associated with hypertension and lower cerebral blood flow in midlife (age ?55 years); however, whether these variants are a result of aging or long-term (...) (Hypertension)
10:01
Acute Increase of Renal Perfusion Pressure Causes Rapid Activation of mTORC1 (Mechanistic Target Of Rapamycin Complex 1) and Leukocyte Infiltration - Satoshi Shimada Chun Yang Vikash Kumar David L. Mattson Allen W. Cowley Department of Physiology, Medical College of Wisconsin, Milwaukee (S.S., C.Y., V.K., D.L.M., A.W.C.). Now with: Department of Physiology, Medical College of Georgia at Augusta University (D.L.M.). Hypertension

Hypertension, Volume 79, Issue 6, Page 1180-1189, June 1, 2022. Background:The present study in Sprague-Dawley rats determined the effects of a rapid rise of renal perfusion pressure (RPP) upon the activation of mTOR (mechanistic target of rapamycin), and the effects upon the infiltration of (...) (Hypertension)
10:00
Utilizing Mobile Health Units for Mass Hypertension Screening in Socially Vulnerable Communities Across Detroit - Robert D. Brook Katee Dawood Bethany Foster Randi M. Foust Catherine Gaughan Paul Kurian Brian Reed Andrea L. Jones Barbara Vernon Phillip D. Levy Division of Cardiovascular Diseases (R.D.B.), Wayne State University. Integrative Biosciences Center (R.D.B., K.D., B.F., B.R., A.L.J., P.D.L.), Wayne State University. Wayne Health (R.D.B., R.M.F., C.G., P.K., B.V., P.D.L.), Wayne State University. Department of Emergency Medicine (B.F., A.L.J., P.D.L.), Wayne State (...) Hypertension

Hypertension, Volume 79, Issue 6, Page e106-e108, June 1, 2022. (Hypertension)
10:00
Is the Pannexin-1 Channel a Mechanism Underlying Hypertension in Humans? a Translational Study of Human Hypertension - Lasse Gliemann Andrea Tamariz-Ellemann Camilla Collin Hansen Thomas Svare Ehlers Sophie Møller Ylva Hellsten Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark. Hypertension

Hypertension, Volume 79, Issue 5, Page 1132-1143, May 1, 2022. Background:In preclinical models, the pannexin-1 channel has been shown to be involved in blood pressure regulation through an effect on peripheral vascular resistance. Pannexin-1 releases ATP, which can activate constrictive (...) (Hypertension)

11 March

Hypertension https://www.ahajournals.org/

11:00
Emerging Viral Infections, Hypertension, and Cardiovascular Disease in Sub-Saharan Africa: A Narrative Review - Lily D. Yan Sarah S. Matuja Kevin J. Pain Margaret L. McNairy Anthony O. Etyang Robert N. Peck Center for Global Health and Division of General Internal Medicine (L.D.Y., M.L.M., R.N.P.), Weill Cornell Medicine, New York, NY. Samuel J. Wood Library and C.V. Starr Biomedical Information Center (K.J.P.), Weill Cornell Medicine, New York, NY. Department of Medicine, Weill Bugando School of Medicine, Mwanza, Tanzania (S.S.M., R.N.P.). KEMRI-Wellcome Trust Research Program, Kilifi, Kenya (A.O.E.). Mwanza Interventions Trial Unit, Mwanza, Tanzania (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 898-905, May 1, 2022. Background:Sub-Saharan Africa (SSA) has the highest age-adjusted burden of hypertension and cardiovascular disease (CVD). SSA also experiences many viral infections due to unique environmental and societal factors. The purpose of this (...) (Hypertension)

10 March

Hypertension https://www.ahajournals.org/

11:00
Inverse Association Between Variety of Proteins With Appropriate Quantity From Different Food Sources and New-Onset Hypertension - Chun Zhou Qimeng Wu Ziliang Ye Mengyi Liu Zhuxian Zhang Yuanyuan Zhang Huan Li Panpan He Qinqin Li Chengzhang Liu Xianhui Qin National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Division of Nephrology, Nanfang Hospital, Southern Medical University, China (C.Z., Q.W., Z.Y., M.L., Z.Z., Y.Z., H.L., P.H., Q.L., C.L., X.Q.). Department of Epidemiology and Biostatistics, School of Public Health (Q.L., C.L., X.Q.), (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 1017-1027, May 1, 2022. The relationships of the variety and quantity of different sources of dietary proteins with hypertension remain uncertain. We aimed to investigate associations between the variety and quantity of proteins intake from 8 major food (...) (Hypertension)
11:00
Cost-Effectiveness of Antihypertensive Deprescribing in Primary Care: a Markov Modelling Study Using Data From the OPTiMISE Trial - Sue Jowett Shahela Kodabuckus Gary A. Ford F.D. Richard Hobbs Mark Lown Jonathan Mant Rupert Payne Richard J. McManus James P. Sheppard Institute of Applied Health Research, University of Birmingham, United Kingdom (S.J., S.K.). Oxford University Hospitals NHS Foundation Trust and University of Oxford, United Kingdom (G.A.F.). Nuffield Department of Primary Care Health Sciences, University of Oxford, United Kingdom (F.D.R.H., R.J.M., J.P.S.). Primary Care Research Centre, University of Southampton, Southampton, United Kingdom (M.L.). Primary Care Unit, Department of Public Health & (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 1122-1131, May 1, 2022. Background:Deprescribing of antihypertensive medications for older patients with normal blood pressure is recommended by some clinical guidelines, where the potential harms of treatment may outweigh the benefits. This study aimed to (...) (Hypertension)
11:00
Diagnosis and Monitoring of White Coat Hypertension in Pregnancy: an ISSHP Consensus Delphi Procedure - Sonia Johnson Sanne Gordijn Stefanie Damhuis Wessel Ganzevoort Mark Brown Peter von Dadelszen Laura A. Magee Asma Khalil Barts and the London Medical School, Queen Mary University of London, United Kingdom (S.J.). Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, the Netherlands (S.G., S.D.). Department of Obstetrics and Gynaecology, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands (W.G.). Department of Renal Medicine, St. George Hospital and University of New South Wales, Sydney, Australia (M.B.). (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 993-1005, May 1, 2022. Background:There is no accepted definition or standardized monitoring for white coat hypertension in pregnancy. This Delphi procedure aimed to reach consensus on out-of-office blood pressure (BP) monitoring, and white coat (...) (Hypertension)

9 March

Hypertension https://www.ahajournals.org/

11:00
Impact of Antihypertensive Drug Class on Outcomes in SPRINT - Douglas D. DeCarolis Amy Gravely Christine M. Olney Areef Ishani Minneapolis VA Health Care System, MN (D.D.D.). Research Service, Minneapolis VA Health Care System, MN (A.G., C.M.O.). University of Minnesota, School of Nursing and University of Minnesota, Rehabilitation Medicine, Minneapolis, MN (C.M.O.). Minneapolis VA Health Care System and University of Minnesota‚ MN (A.I.). Hypertension

Hypertension, Volume 79, Issue 5, Page 1112-1121, May 1, 2022. Background:The primary objective of this analysis is to assess if greater exposure to any major antihypertensive drug class was associated with reduced primary composite outcome events in SPRINT (Systolic Blood Pressure Intervention (...) (Hypertension)
08:00
White-Coat Free Genome-Wide Epigenetics of Human Blood Pressure - Daniel Vaiman Institut Cochin, U1016 INSERM-UMR8104 CNRS, Université de Paris, France. Hypertension

Hypertension, Volume 79, Issue 4, Page 773-774, April 1, 2022. (Hypertension)
08:00
Aldosterone and Aortic Aneurysms: the Dissection of a Potential New Mechanism to Prevent Rupture - Suman Srinivasa Yan E. Yuan Gail K. Adler Metabolism Unit, Massachusetts General Hospital (S.S.), Harvard Medical School, Boston, MA. Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital (Y.E.Y., G.K.A.), Harvard Medical School, Boston, MA. Hypertension

Hypertension, Volume 79, Issue 4, Page 747-749, April 1, 2022. (Hypertension)
08:00
Another Nail in the Coffin of Causality for the Diastolic Blood Pressure J Curve - John P. Birrane Matteo Foschi Simona Sacco John W. McEvoy National Institute for Prevention and Cardiovascular Health, National University of Ireland Galway School of Medicine, Galway, Ireland (J.P.B., J.W.M.). Department of Neuroscience, Neurology Unit, S. Maria delle Croci Hospital of Ravenna, AUSL Romagna, Italy (M.F.). Department of Medical and Surgical Sciences, University of Bologna, Italy (M.F.). Neuroscience Section, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy (S.S.). Division of Cardiology, Department of Medicine, Ciccarone Center (...) Hypertension

Hypertension, Volume 79, Issue 4, Page 794-797, April 1, 2022. (Hypertension)
08:00
Will Food and Drug Administration Guidance to Reduce the Salt Content of Processed Foods Reduce Salt Intake and Save Lives? - Theodore W. Kurtz Michal Pravenec Stephen E. DiCarlo Department of Laboratory Medicine, University of California, San Francisco (T.W.K.). Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic (M.P.). Department of Physiology, College of Osteopathic Medicine, Michigan State University, East Lansing (S.E.D.). Hypertension

Hypertension, Volume 79, Issue 4, Page 809-812, April 1, 2022. (Hypertension)

8 March

Hypertension https://www.ahajournals.org/

11:00
Carotid Intima-Media Thickness Percentiles in Adolescence and Young Adulthood and Their Association With Obesity and Hypertensive Blood Pressure in a Population Cohort - Hannelore K. Neuhauser Julia Büschges Angelika Schaffrath Rosario Anja Schienkiewitz Giselle Sarganas Karsten Königstein Dieter Schweizer Arno Schmidt-Trucksäss Robert Koch Institute, Department of Epidemiology and Health Monitoring, Berlin, Germany (H.K.N., J.B., A.S.R., A.S., G.S.). DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany (H.K.N., J.B., A.S., G.S., K.K.). Department of Sport, Exercise and Health, Division Sports and Exercise Medicine, University of Basel, Switzerland (K.K., A.S.-T.). Fukuda Denshi Switzerland AG, Basel, Switzerland (...) Hypertension

Hypertension, Volume 79, Issue 6, Page 1167-1176, June 1, 2022. Background:This study aimed to derive carotid intima media thickness (CIMT) percentiles from a population-based sample of adolescents and young adults using improved technology, standardization and quality control, and to (...) (Hypertension)

7 March

Hypertension https://www.ahajournals.org/

11:00
Adolescent Blood Pressure and the Risk for Early Kidney Damage in Young Adulthood - Avishai M. Tsur Inbal Akavian Estela Derazne Dorit Tzur Asaf Vivante Ehud Grossman Ran S. Rotem Boris Fishman Arnon Afek Josef Coresh Gabriel Chodick Gilad Twig Israel Defense Forces, Medical Corps, Tel Hashomer, Ramat Gan, Israel (A.M.T., I.A., E.D., D.T., G.T.). Department of Military Medicine, Hebrew University of Jerusalem Faculty of Medicine, Jerusalem, Israel (A.M.T., I.A., G.T.). Department of Medicine (A.M.T., E.G., B.F.), Sheba Medical Center, Tel-Hashomer, Israel. Department of Pediatrics B and Pediatric Nephrology Unit, Edmond and Lily Safra Children’s Hospital (A.V.), Sheba (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 974-983, May 1, 2022. Background:Recent guidelines classified blood pressure above 130/80 mm Hg as hypertension. However, outcome data were lacking.Objective:To determine the association between blood pressure in adolescence and the risk for early kidney (...) (Hypertension)
11:00
Upregulation of Endothelial DKK1 (Dickkopf 1) Promotes the Development of Pulmonary Hypertension Through the Sp1 (Specificity Protein 1)/SHMT2 (Serine Hydroxymethyltransferase 2) Pathway - Qianqian Wang Jingjing Tian Xuan Li Xiaolin Liu Tengfei Zheng Yachao Zhao Xiao Li Hongyu Zhong Dongdong Liu Wencheng Zhang Meng Zhang Mengmeng Li Mei Zhang The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 960-973, May 1, 2022. Background:Pulmonary hypertension (PH) is a cancer-like proliferative disease, which has no curative treatment options. The dysfunction of pulmonary artery endothelial cells plays a key role in PH. DKK1 (Dickkopf 1) is a secretory (...) (Hypertension)

4 March

Hypertension https://www.ahajournals.org/

11:00
Risk Stratification by Cross-Classification of Central and Brachial Systolic Blood Pressure - Yi-Bang Cheng Lutgarde Thijs Lucas S. Aparicio Qi-Fang Huang Fang-Fei Wei Yu-Ling Yu Jessica Barochiner Chang-Sheng Sheng Wen-Yi Yang Teemu J. Niiranen José Boggia Zhen-Yu Zhang Katarzyna Stolarz-Skrzypek Natasza Gilis-Malinowska Valérie Tikhonoff Wiktoria Wojciechowska Edoardo Casiglia Krzysztof Narkiewicz Jan Filipovský Kalina Kawecka-Jaszcz Ji-Guang Wang Yan Li Jan A. Staessen Department of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 1101-1111, May 1, 2022. Background:Whether cardiovascular risk is more tightly associated with central (cSBP) than brachial (bSBP) systolic pressure remains debated, because of their close correlation and uncertain thresholds to differentiate cSBP into (...) (Hypertension)

2 March

Hypertension https://www.ahajournals.org/

11:02
Capsaicin Attenuates Arterial Calcification Through Promoting SIRT6-Mediated Deacetylation and Degradation of Hif1? (Hypoxic-Inducible Factor-1 Alpha) - Dongling Luo Wenxin Li Changming Xie Li Yin Xiaoyan Su Jie Chen Hui Huang Department of Cardiology, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China (D.L., W.L., C.X., L.Y., H.H.). Department of Radiation Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China (J.C.). Department of Nephropathy, Tungwah Hospital of Sun Yat-sen University, Dongguan, China (X.S.). Hypertension

Hypertension, Volume 79, Issue 5, Page 906-917, May 1, 2022. Background:Sustained Hif1? (hypoxic-inducible factor-1 alpha) accumulation plays a central role in osteogenic transdifferentiation and subsequent calcification. Capsaicin, the potent agonist of TRPV1 (transient receptor potential (...) (Hypertension)
11:00
Platelet-Derived TGF (Transforming Growth Factor)-?1 Enhances the Aerobic Glycolysis of Pulmonary Arterial Smooth Muscle Cells by PKM2 (Pyruvate Kinase Muscle Isoform 2) Upregulation - Ying Zhu Dan Shu Xue Gong Meng Lu Qinyu Feng Xiang-Bin Zeng Han Zhang Jiahui Gao Ya-Wei Guo Luman Liu Rong Ma Liping Zhu Qinghua Hu Zhang-Yin Ming Department of Pharmacology, School of Basic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China (Y.Z., D.S., X.G., M.L., X.-B.Z., J.G., Y.W.G., L.L., R.M., Z.-Y.M.). The Key Laboratory for Drug Target Research and Pharmacodynamic Evaluation of Hubei Province, Wuhan, China (Y.Z., D.S., X.G., M.L., X.-B.Z., J.G., Y.W.G., L.L., R.M., Z.-Y.M.). Department of Pharmacy, School of Medicine, Wuhan University (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 932-945, May 1, 2022. Background:Metabolic reprogramming is a hallmark of pulmonary arterial hypertension. Platelet activation has been implicated in pulmonary arterial hypertension (PAH), whereas the role of platelet in the pathogenesis of PAH remains (...) (Hypertension)
11:00
Myeloid Piezo1 Deletion Protects Renal Fibrosis by Restraining Macrophage Infiltration and Activation - Yu He Bo Deng Silin Liu Shangfei Luo Yile Ning Xianmei Pan Rentao Wan Yuan Chen Ziyan Zhang Jintao Jiang Honglin Xu Mingfeng Xia Jing Li Lingnan Medical Research Center (Y.H., B.D., S. Liu, S. Luo, Y.N., X.P., R.W., Y.C., Z.Z., J.J., H.X., J.L.) The First Affiliated Hospital (Y.H., B.D., S. Liu, S. Luo, Y.N., X.P., R.W., Y.C., Z.Z., J.J., H.X., J.L.), Guangzhou University of Chinese Medicine. Medical Research Center, Shandong University of Chinese Medicine, Jinan, China (M.X.). Faculty of Biological Sciences, University of Leeds, United Kingdom (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 918-931, May 1, 2022. Background:Macrophages play important roles in renal fibrosis, partially by sensing mechanical forces, including shear stress and increased stiffness. The mechanically activated cationic channel Piezo1 drives vascular formation and (...) (Hypertension)
11:00
Microvascular ?-Adrenergic Receptor-Mediated Vasodilation Is Attenuated in Adults With Major Depressive Disorder - Jody L. Greaney Ashley M. Darling Jacqueline Mogle Erika F.H. Saunders Department of Kinesiology, The University of Texas at Arlington (J.L.G., A.M.D.). Edna Bennett Pierce Prevention Research Center, The Pennsylvania State University, University Park, PA (J.M.). Department of Psychiatry and Behavioral Health, Penn State College of Medicine, Hershey, PA (E.F.H.S.). Hypertension

Hypertension, Volume 79, Issue 5, Page 1091-1100, May 1, 2022. Background:Major depressive disorder (MDD) is associated with sympathetic overactivity and alterations in peripheral adrenergic receptor function; however, no studies have directly assessed vasoconstrictor responsiveness in adults (...) (Hypertension)
11:00
Worsening Postural Tachycardia Syndrome Is Associated With Increased Glucose-Dependent Insulinotropic Polypeptide Secretion - Nicholas C. Breier Sachin Y. Paranjape Shea Scudder Shahram E. Mehr Andre’ Diedrich Charles R. Flynn Luis E. Okamoto Bolette Hartmann Lærke Smidt Gasbjerg Cyndya A. Shibao Department of Medicine, Division of Clinical Pharmacology (N.C.B., S.Y.P., S.S., S.E.M., A.D., L.E.O., C.A.S.), Vanderbilt University Medical Center, Nashville, TN. Department of Surgery (C.R.F.), Vanderbilt University Medical Center, Nashville, TN. Department of Biomedical Science (B.H., L.S.G.), University of Copenhagen, Denmark. Novo Nordisk Foundation Center for Basic Metabolic Research (B.H.), University of (...) Hypertension

Hypertension, Volume 79, Issue 5, Page e89-e99, May 1, 2022. Background:Postural tachycardia syndrome (POTS) is characterized by excessive upright tachycardia and disabling presyncopal symptoms, which are exacerbated after consuming a high-carbohydrate meal; it is unknown, however, what is the (...) (Hypertension)

25 February

Hypertension https://www.ahajournals.org/

11:00
Hypertensive Disorders of Pregnancy With and Without Prepregnancy Hypertension Are Associated With Incident Maternal Kidney Disease Subsequent to Delivery - Angela M. Malek Kelly J. Hunt Tanya N. Turan Julio Mateus Daniel T. Lackland Anika Lucas Dulaney A. Wilson Department of Public Health Sciences (A.M.M., K.J.H., D.A.W.), Medical University of South Carolina, Charleston. Department of Neurology (T.N.T., D.T.L.), Medical University of South Carolina, Charleston. Department of Obstetrics & Gynecology, Maternal-Fetal Medicine Division, Atrium Health, Charlotte, NC (J.M.). Department of Medicine, Division of Nephrology, Duke University, Durham, NC (...) Hypertension

Hypertension, Volume 79, Issue 4, Page 844-854, April 1, 2022. Background:Maternal morbidity and mortality are related to prepregnancy hypertensive disease and hypertensive disorders of pregnancy (HDP) including preeclampsia (41.1% of HDP), eclampsia (1.3% of HDP), and gestational hypertension (...) (Hypertension)

23 February

Hypertension https://www.ahajournals.org/

11:00
Effect of Antihypertensive Treatment on Cerebral Blood Flow in Older Adults: a Systematic Review and Meta-Analysis - Anniek E. van Rijssel Bram C. Stins Lucy C. Beishon Marit L. Sanders Terence J. Quinn Jurgen A.H.R. Claassen Rianne A.A. de Heus Radboud university medical center, Donders Institute for Brain Cognition and Behaviour, Department of Geriatric Medicine, Radboudumc Alzheimer Center, Nijmegen, the Netherlands (A.E.v.R., B.C.S., M.L.S., J.A.H.R.C., R.A.A.d.H.). Department of Cardiovascular Sciences, University of Leicester, United Kingdom (L.C.B.). Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 1067-1078, May 1, 2022. Background:In older age, the benefits of antihypertensive treatment (AHT) become less evident, with greater associated risk. Of particular concern is compromising cerebral blood flow (CBF), especially in those with cognitive (...) (Hypertension)
11:00
Glucose Metabolic Disorders Enhance Vascular Dysfunction Triggered by Particulate Air Pollution: a Panel Study - Wu Chen Yiqun Han Yanwen Wang Xi Chen Xinghua Qiu Weiju Li Yifan Xu Tong Zhu BIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Center for Environment and Health (W.C., Y.H., Y.W., X.C., X.Q., Y.X., T.Z.), Peking University, Beijing, China. Peking University Hospital (W.L.), Peking University, Beijing, China. Environmental Research Group, MRC Centre for Environment and Health, Imperial College London, United Kingdom (Y.H.). National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China (Y.W.). Hebei Technology (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 1079-1090, May 1, 2022. Background:Vascular dysfunction is a biological pathway whereby particulate matter (PM) exerts deleterious cardiovascular effects. The effects of ambient PM on vascular function in prediabetic individuals are unclear.Methods:A panel (...) (Hypertension)

22 February

Hypertension https://www.ahajournals.org/

11:00
White-Coat Hypertension Without Organ Damage: Impact on Long-Term Mortality, New Hypertension, and New Organ Damage - Giuseppe Mancia Rita Facchetti Jennifer Vanoli Raffaella Dell’Oro Gino Seravalle Guido Grassi University Milano-Bicocca, Milan (G.M.). Clinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy (R.F., J.V., R.D., G.S., G.G.). Hypertension

Hypertension, Volume 79, Issue 5, Page 1057-1066, May 1, 2022. Background:According to some guidelines, white-coat hypertension (WCH) carries little or no increase of cardiovascular risk in the absence of organ damage (OD), but no data are available on this issue.Methods:Using the population (...) (Hypertension)
11:00
Expression of LHCGR in Pheochromocytomas Unveils an Endocrine Mechanism Connecting Pregnancy and Epinephrine Overproduction - Antoine-Guy Lopez Céline Duparc Sylvie Renouf Elise Machevin Vincent Le Guillou Jean-Christophe Sabourin Guillaume Defortescu Alexandre Buffet Anne-Paule Gimenez-Roqueplo Christophe Dubessy Estelle Louiset Hervé Lefebvre Normandie University, UNIROUEN, INSERM U1239, NorDiC, Rouen, France (A.-G.L., C. Duparc, S.R., C. Dubessy, E.L., H.L.). Department of Endocrinology, Diabetes and Metabolic Diseases (A.-G.L., H.L.), Rouen University Hospital, Rouen‚ France. Department of Thoracic and Cardiovascular Surgery (V.L.G.), Rouen University Hospital, Rouen‚ France. Department of Pathology and INSERM (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 1006-1016, May 1, 2022. Background:The mechanisms by which pregnancy may unmask pheochromocytomas and paragangliomas are not totally understood. We hypothesized that gestational hormones may participate in the pathophysiology of catecholamine excess during (...) (Hypertension)
11:00
Effect of Sunitinib Treatment on Skin Sodium Accumulation in Patients With Renal Cancer: a Pilot Study - Lajos Markó Anne Dörr Peter Linz Anton H. van den Meiracker Ingrid M. Garrelds Titus Kuehne Ralf Dechend A. H. Jan Danser Anne Flörcken Dominik N. Müller Experimental and Clinical Research Center, a cooperation of Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., R.D., D.N.M.). DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany (L.M., D.M.N.). Berlin Institute of Health (BIH), Germany (L.M., R.D., D.N.M.). Charité - Universitätsmedizin Berlin, Germany (L.M., R.D., D.N.M.). Charité–Universitätsmedizin Berlin, (...) Hypertension

Hypertension, Volume 79, Issue 5, Page e103-e105, May 1, 2022. (Hypertension)

21 February

Hypertension https://www.ahajournals.org/

11:00
Delayed Finalization of Sodium Targets in the United States May Cost Over 250 000 Lives by 2031 - Jing Song Mhairi K. Brown Laura K. Cobb Michael F. Jacobson Nicole Ide Graham A. MacGregor Feng J. He Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (J.S., M.K.B., G.A.M., F.J.H.). Resolve to Save Lives, An Initiative of Vital Strategies, New York City (L.K.C., N.I.). Consultant, Washington, DC (M.F.J.). Hypertension

Hypertension, Volume 79, Issue 4, Page 798-808, April 1, 2022. Background:The US Food and Drug Administration (FDA) proposed 2- and 10-year voluntary sodium-reduction targets for >150 packaged- and prepared-food categories in 2016 and finalized the short-term targets in 2021.Methods:We modeled (...) (Hypertension)

18 February

Hypertension https://www.ahajournals.org/

11:00
Diastolic Blood Pressure Variability in Later Life May Be a Key Risk Marker for Cognitive Decline - Ruth Peters Ying Xu Ranmalee Eramudugolla Perminder S. Sachdev Nicolas Cherbuin Phillip J. Tully Moyra E. Mortby Kaarin J. Anstey Neuroscience Research Australia, NSW (R.P., Y.X., R.E., M.E.M., K.J.A.). School of Psychology (R.P., Y.X., R.E., M.E.M., K.J.A.), University of New South Wales, Australia. Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry (P.S.S.), University of New South Wales, Australia. Neuropsychiatric Institute, the Prince of Wales Hospital, Sydney, Australia (P.S.S.). Australian National University (N.C.). Adelaide University, Australia (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 1037-1044, May 1, 2022. Background:There is an increasing awareness of the need to understand the interaction between long-term blood pressure patterns and their impact on the brain and cognition.Methods:Our aim was to investigate the relationship between (...) (Hypertension)

16 February

Hypertension https://www.ahajournals.org/

11:01
Nitroxyl Donor CXL-1020 Lowers Blood Pressure by Targeting C195 in Cyclic Guanosine-3’,5’-Monophosphate-Dependent Protein Kinase I - Alisa Kamynina Sebastian Guttzeit Philip Eaton Friederike Cuello William Harvey Research Institute, Queen Mary University of London, United Kingdom (A.K., S.G., P.E.). Institute of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Germany (F.C.). DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, University Medical Center Hamburg-Eppendorf, Germany (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 946-956, May 1, 2022. Background:We previously demonstrated that nitroxyl causes vasodilation, at least in part, by inducing the formation of an intradisulfide bond between C117 and C195 in the high affinity cyclic guanosine monophosphate-binding site of (...) (Hypertension)
11:00
Arterial Stiffness and Long-Term Risk of Health Outcomes: The Framingham Heart Study - Ramachandran S. Vasan Stephanie Pan Vanessa Xanthakis Alexa Beiser Martin G. Larson Sudha Seshadri Gary F. Mitchell Section of Preventive Medicine and Epidemiology (R.S.V., V.X.), Boston University School of Medicine, Boston, MA. Department of Neurology (A.B., S.S.), Boston University School of Medicine, Boston, MA. Framingham Heart Study, MA (R.S.V., V.X., A.B., M.G.L., S.S.). Department of Epidemiology (R.S.V.), Boston University School of Public Health, MA. Department of Biostatistics (S.P., V.X., A.B., M.G.L.), Boston University School of Public Health, MA. Biggs Institute for (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 1045-1056, May 1, 2022. Background:Arterial stiffness increases with age and is associated with an increased risk of adverse outcomes on short-term follow-up (typically (Hypertension)

15 February

Hypertension https://www.ahajournals.org/

11:00
Chronic Kidney Disease and Left Ventricular Hypertrophy. Potent Modifiers of the Prognostic Impact of Circadian Blood Pressure Changes - Paolo Verdecchia Fabio Angeli Gianpaolo Reboldi Fondazione Umbra Cuore e Ipertensione-ONLUS and Division of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy (P.V.). Department of Medicine and Surgery, University of Insubria, Varese (F.A.). Department of Medicine and Cardiopulmonary Rehabilitation, Maugeri Care and Research Institute, IRCCS Tradate, Italy (F.A.). Department of Medicine, Centro di Ricerca Clinica e Traslazionale (CERICLET), University of Perugia, Italy (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 1028-1036, May 1, 2022. Background:It is unclear whether the prognostic value of blood pressure (BP) changes from day to night is modified by concomitant risk factors and organ damage.Methods:We studied 3247 clinically hypertensive patients who underwent (...) (Hypertension)
11:00
Association of Different Definitions of Intradialytic Hypertension With Long-Term Mortality in Hemodialysis - Anika T. Singh Sushrut S. Waikar Finnian R. Mc Causland Renal Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (A.T.S., F.R.M.C.). Harvard Medical School, Boston, MA (A.T.S., F.R.M.C.). Renal Section, Boston Medical Center, MA (S.S.W.). Boston University School of Medicine (S.S.W.). Hypertension

Hypertension, Volume 79, Issue 4, Page 855-862, April 1, 2022. Background:Hypertension is common in hemodialysis patients. A subset of patients experience systolic blood pressure increases from prehemodialysis to posthemodialysis (intradialytic hypertension), which are associated with adverse (...) (Hypertension)
11:00
Racial Differences in XO (Xanthine Oxidase) and Mitochondrial DNA Damage-Associated Molecular Patterns in Resistant Hypertension - Brittany Butts Jamelle A. Brown Thomas S. Denney Scott Ballinger Steven G. Lloyd Suzanne Oparil Paul Sanders Tony R. Merriman Angelo Gaffo Jasvinder Singh Eric E. Kelley David A. Calhoun Louis J. Dell’Italia Division of Cardiovascular Disease, University of Alabama at Birmingham (UAB) School of Medicine (SOM) (B.B., S.G.L., S.O., P.S., D.A.C., L.J.D.). Center for Free Radical Biology and Department of Pathology, UAB SOM (J.A.B., S.B.). Department of Electrical and Computer Engineering, Auburn University (T.S.D.). Nephrology Research and Training Center and Division of Nephrology UAB SOM (...) Hypertension

Hypertension, Volume 79, Issue 4, Page 775-784, April 1, 2022. Background:We previously reported increased plasma XO (xanthine oxidase) activity in patients with resistant hypertension. Increased XO can cause mitochondrial DNA damage and promote release of fragments called mitochondrial DNA (...) (Hypertension)

11 February

Hypertension https://www.ahajournals.org/

11:00
Role of Extracellular Vesicles in the Pathogenesis of Vascular Damage - Fabrizio Buffolo Silvia Monticone Giovanni Camussi Elena Aikawa Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences (F.B., S.M.), University of Torino, Italy. Department of Medical Sciences, Molecular Biotechnology Center (G.C.), University of Torino, Italy. Center for Interdisciplinary Cardiovascular Sciences, Department of Cardiovascular Medicine (F.B, E.A.), Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. Center for Excellence in Vascular Biology, Department of Cardiovascular Medicine (E.A.), Brigham and Women’s Hospital, Harvard Medical (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 863-873, May 1, 2022. Extracellular vesicles (EVs) are nanosized membrane-bound structures released by cells that are able to transfer nucleic acids, protein cargos, and metabolites to specific recipient cells, allowing cell-to-cell communications in an (...) (Hypertension)
11:00
Low Chloride–Regulated ClC-5 Contributes to Arterial Smooth Muscle Cell Proliferation and Cerebrovascular Remodeling - Min Gao Ming-Ming Ma Feng-Ting Lu Cheng-Cui Huang Lu Sun Xiao-Fei Lv Bin Zhang Guan-Lei Wang Yong-Yuan Guan Department of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine (M.G., M.-M.M., F.-T.L., C.-C.H., L.S., X.-F.L., G.-L.W., Y.-Y.G.), Sun Yat-Sen University, Guangzhou, China. Department of Pharmacy, The Sixth Affiliated Hospital (M.G., C.-C.H.), Sun Yat-Sen University, Guangzhou, China. Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, (...) Hypertension

Hypertension, Volume 79, Issue 4, Page e73-e85, April 1, 2022. Background:Low serum chloride (Cl?) level is considered an independent predictor of cardiovascular mortality associated with chronic hypertension. However, the underlying mechanisms are unknown. ClC-5, a member of the Cl?channel (...) (Hypertension)

10 February

Hypertension https://www.ahajournals.org/

11:00
Genetics of Primary Aldosteronism - Ute I. Scholl Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Center of Functional Genomics, Germany. Hypertension

Hypertension, Volume 79, Issue 5, Page 887-897, May 1, 2022. Primary aldosteronism is considered the commonest cause of secondary hypertension. In affected individuals, aldosterone is produced in an at least partially autonomous fashion in adrenal lesions (adenomas, [micro]nodules or diffuse (...) (Hypertension)
11:00
Aortic Pulse Wave Velocity as Adjunct Risk Marker for Assessing Cardiovascular Disease Risk: Prospective Study - Carlos A. Valencia-Hernández Joni V. Lindbohm Martin J. Shipley Ian B. Wilkinson Carmel M. McEniery Sara Ahmadi-Abhari Archana Singh-Manoux Mika Kivimäki Eric J. Brunner Research Department of Epidemiology and Public Health, University College London, London, United Kingdom (C.A.V.-H., J.V. L., M.J.S., A.S.-M., M.K., E.J.B.). Clinicum, Department of Public Health, University of Helsinki (J.V.L.). Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom (I.B.W., C.M.M.). Ageing Epidemiology Research Unit, Imperial College London, United Kingdom (S.A.-A.). Université de (...) Hypertension

Hypertension, Volume 79, Issue 4, Page 836-843, April 1, 2022. Background:Aortic pulse wave velocity is a noninvasive measure of aortic stiffness and arterial aging. Its current value in cardiovascular risk estimation practice is unknown. We aimed to establish whether aortic pulse wave velocity (...) (Hypertension)

9 February

Hypertension https://www.ahajournals.org/

11:00
With a Little Help From My Friends: the Role of the Renal Collateral Circulation in Atherosclerotic Renovascular Disease - Jakob Nyvad Amir Lerman Lilach O. Lerman Division of Nephrology and Hypertension (J.N., L.O.L.), Mayo Clinic, Rochester, MN. Department of Cardiovascular Medicine (A.L.), Mayo Clinic, Rochester, MN. Department of Nephrology and Hypertension, Aarhus University Hospital, Aarhus, Denmark (J.N.). Hypertension

Hypertension, Volume 79, Issue 4, Page 717-725, April 1, 2022. The collateral circulation can adapt to bypass major arteries with limited flow and serves a crucial protective role in coronary, cerebral, and peripheral arterial disease. Emerging evidence indicates that the renal collateral (...) (Hypertension)
08:00
Correction to: Do ?-Blockers Cause Depression? Systematic Review and Meta-Analysis of Psychiatric Adverse Events During ?-Blocker Therapy Hypertension

Hypertension, Volume 79, Issue 3, Page e72-e72, March 1, 2022. (Hypertension)
08:00
Interrelations Between High Blood Pressure, Organ Damage, and Cardiovascular Disease: No More Room for Doubt - Karri Suvila Teemu J. Niiranen Department of Medicine, Turku University Hospital and University of Turku, Finland (K.S., T.J.N.). Department of Public Health Solutions, Finnish Institute for Health and Welfare, Turku, Finland (T.J.N.). Hypertension

Hypertension, Volume 79, Issue 3, Page 516-517, March 1, 2022. (Hypertension)
08:00
Great Chinese Famine and the Effects on Cardiometabolic Health for Future Generations - Korbua Srichaikul Robert A. Hegele David J.A. Jenkins Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Ontario, Canada (K.S., D.J.A.J.). Clinical Nutrition Risk Factor Modification Centre, St. Michael’s Hospital, Toronto, Ontario, Canada (K.S., D.J.A.J.). Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada (K.S., D.J.A.J.). Department of Medicine, Western University, London, Ontario, Canada (R.A.H.). Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Ontario, Canada (D.J.A.J.). Li Ka Shing Knowledge Institute (...) Hypertension

Hypertension, Volume 79, Issue 3, Page 532-535, March 1, 2022. (Hypertension)
08:00
Correction to: Hypertension in Pregnancy: Diagnosis, Blood Pressure Goals, and Pharmacotherapy: A Scientific Statement From the American Heart Association Hypertension

Hypertension, Volume 79, Issue 3, Page e70-e70, March 1, 2022. (Hypertension)
08:00
Correction to: Calcitonin Gene-Related Peptide Protects Against Cardiovascular Dysfunction Independently of Nitric Oxide In Vivo Hypertension

Hypertension, Volume 79, Issue 3, Page e71-e71, March 1, 2022. (Hypertension)

7 February

Hypertension https://www.ahajournals.org/

11:00
Acute Induced Pressure Overload Rapidly Incites Thoracic Aortic Aneurysmal Smooth Muscle Cell Phenotype - Albert J. Pedroza Rohan Shad Alex R. Dalal Nobu Yokoyama Ken Nakamura William Hiesinger Michael P. Fischbein Department of Cardiothoracic Surgery, Stanford University School of Medicine, CA. Hypertension

Hypertension, Volume 79, Issue 4, Page e86-e89, April 1, 2022. (Hypertension)

4 February

Hypertension https://www.ahajournals.org/

11:00
New Noninvasive Methods to Evaluate Microvascular Structure and Function - Damiano Rizzoni Alessandro Mengozzi Stefano Masi Claudia Agabiti Rosei Carolina De Ciuceis Agostino Virdis Clinica Medica, Department of Clinical and Experimental Sciences, University of Brescia, Italy (D.R., C.A., C.D.C.). Division of Medicine, Spedali Civili di Brescia, Montichiari (Brescia), Italy (D.R.). Department of Clinical and Experimental Medicine, University of Pisa, Italy (A.M., S.M., A.V.). Institute of Life Science, Sant’Anna School of Advanced Studies, Pisa, Italy (A.M.). Institute of Cardiovascular Science, University College London, United Kingdom (...) Hypertension

Hypertension, Volume 79, Issue 5, Page 874-886, May 1, 2022. The structural and functional alterations of microvessels are detected because of physiological aging and in several cardiometabolic diseases, including hypertension, diabetes, and obesity. The small resistance arteries of these (...) (Hypertension)
11:01
Influence of Baseline Diastolic Blood Pressure on the Effects of Intensive Systolic Blood Pressure Lowering on the Risk of Stroke - Saeed Shihab Robert E. Boucher Nikita Abraham Guo Wei Srinivasan Beddhu Division of Nephrology & Hypertension, University of Utah School of Medicine, Salt Lake City (S.S., R.E.B., N.A., G.W., S.B.). Medical Service, Veterans Affairs Salt Lake City Health Care System (S.B.). Hypertension

Hypertension, Volume 79, Issue 4, Page 785-793, April 1, 2022. Background:Guidelines recommend lowering systolic blood pressure below 130 mm Hg, irrespective of previous strokes. However, there is a concern that lowering systolic blood pressure in people with low baseline diastolic blood (...) (Hypertension)

3 February

Hypertension https://www.ahajournals.org/

11:00
Regulation of Blood Pressure and Salt Balance By Pendrin-Positive Intercalated Cells: Donald Seldin Lecture 2020 - Susan M. Wall Department of Medicine, Emory University School of Medicine, Atlanta, GA. Hypertension

Hypertension, Volume 79, Issue 4, Page 706-716, April 1, 2022. Intercalated cells make up about a third of all cells within the connecting tubule and the collecting duct and are subclassified as type A, type B and non-A, non-B based on the subcellular distribution of the H+-ATPase, which (...) (Hypertension)

31 January

Hypertension https://www.ahajournals.org/

11:00
Exploring Overweight Risk Trajectories During Childhood and Their Associations With Elevated Blood Pressure at Late Adolescence: a Retrospective Cohort Study - Xijie Wang Jie Hu Sizhe Huang Zhaogeng Yang Yanhui Dong Bin Dong Jun Ma Wannian Liang Vanke School of Public Health (X.W., W.L.), Tsinghua University, Beijing, China. Institute for Healthy China (X.W., W.L.), Tsinghua University, Beijing, China. Institute of Child and Adolescent Health & School of Public Health, Peking University Health Science Center, Beijing, China (X.W., Z.Y., Y.D., B.D., J.M.). Menzies Health Institute Queensland, Griffith University, Australia (J.H.). Zhongshan Health Care Centers for Primary and Secondary School, Guangdong, China (...) Hypertension

Hypertension, Volume 79, Issue 8, Page 1605-1613, August 1, 2022. Background:Overweight during childhood is significantly associated with higher risk of high blood pressure (HBP) in later life. However, recognition of critical intervention period is limited. We aimed to analyze the changes in (...) (Hypertension)
11:00
Immune System and Microvascular Remodeling in Humans - Damiano Rizzoni Carolina De Ciuceis Piotr Szczepaniak Pierre Paradis Ernesto L. Schiffrin Tomasz J. Guzik Clinica Medica, Department of Clinical and Experimental Sciences, University of Brescia, Italy (D.R., C.D.C.). Division of Medicine, Spedali Civili di Brescia, Montichiari, Italy (D.R.). Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (P.S., T.J.G.). Department of Medicine, Jagiellonian University Medical College, Krakow, Poland (P.S., T.J.G.). Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, Montreal, Québec, (...) Hypertension

Hypertension, Volume 79, Issue 4, Page 691-705, April 1, 2022. Low-grade inflammatory processes and related oxidative stress may have a key role in the pathogenesis of hypertension and hypertension-mediated organ damage. Innate immune cells, such as neutrophils, dendritic cells, (...) (Hypertension)

Articles récents

Préférences

Sources

Accueil du site

permalink

25 January

23 January

19 January

18 January

11 January

10 January

9 January

6 January

5 January

30 December

15 December

13 December

7 December

6 December

5 December

2 December

30 November

28 November

23 November

21 November

18 November

17 November

15 November

11 November

10 November

8 November

7 November

4 November

31 October

19 October

18 October

3 October

26 September

23 September

21 September

16 September

9 September

7 September

6 September

23 August

3 August

1 August

29 July

26 July

25 July

22 July

20 July

18 July

13 July

11 July

8 July

7 July

30 June

29 June

28 June

22 June

21 June

20 June

16 June

15 June

13 June

10 June

8 June

6 June

3 June

2 June

31 May

26 May

24 May

23 May

19 May

18 May