30 June

Hypertension https://www.ahajournals.org/

• 11:00
  Seasonal Variation in Day-by-Day Home Blood Pressure Variability and Effect on Cardiovascular Disease Incidence - Keisuke Narita Satoshi Hoshide Kazuomi Kario Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University School of Medicine, Tochigi, Japan. Hypertension
  Hypertension, Ahead of Print. Background:Although day-by-day home blood pressure (BP) variability (BPV) has been associated with cardiovascular disease (CVD) risk, it remains unclear whether this association differs from season to season. The present study aimed to assess seasonal variation in (...) (Hypertension)

29 June

Hypertension https://www.ahajournals.org/

• 11:02
  Influence of Obstructive Sleep Apnea Severity on Muscle Sympathetic Nerve Activity and Blood Pressure: a Systematic Review and Meta-Analysis - Lauren E. Maier Brittany A. Matenchuk Ana Vucenovic Allison Sivak Margie H. Davenport Craig D. Steinback Neurovascular Health Laboratory, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Canada. (L.E.M., A.V., C.D.S.) Program for Pregnancy and Postpartum Health, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Canada. (B.A.M., M.H.D.) H.T. Coutts Education and Physical Education Library, University of Alberta, Edmonton, Canada. (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:We conducted meta-analyses to identify relationships between obstructive sleep apnea (OSA) severity, muscle sympathetic nerve activity (MSNA), and blood pressure (BP). We quantified the effect of OSA treatment on MSNA.METHODS:Structured searches of (...) (Hypertension)
• 11:01
  Aldosterone as a Mediator of Cardiovascular Damage - Fabrizio Buffolo Martina Tetti Paolo Mulatero Silvia Monticone Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Torino, Italy. Hypertension
  Hypertension, Ahead of Print. Besides the physiological regulation of water, sodium, and potassium homeostasis, aldosterone modulates several physiological and pathological processes in the cardiovascular system. At the vascular level, aldosterone excess stimulates endothelial dysfunction and (...) (Hypertension)
• 11:01
  Age and Blood Pressure Contribute to Aortic Cell and Tissue Stiffness Through Distinct Mechanisms - Ben Ma Elaina Melton Robert Wiener Ning Zhou Wenqian Wu Lo Lai Charles Wang Kevin D. Costa Hongyu Qiu Center for Molecular and Translational Medicine, Institute of Biomedical Sciences, Georgia State University, Atlanta, GA (B.M., E.M., W.W., L.L., H.Q.). Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY (R.W., K.D.C.). Division of Physiology, Department of Basic Sciences, School of Medicine, Loma Linda University, CA (B.M., N.Z., H.Q.) Department of Basic Sciences & Center for Genomics, School of Medicine, Loma (...) Hypertension
  Hypertension, Ahead of Print. Background:Aortic stiffening is strongly associated with both aging and hypertension, but the underlying mechanisms remain unclear. We hypothesized that aging-induced aortic stiffness involves distinct pathways than stiffening from hypertension.Methods:We conducted (...) (Hypertension)
• 11:00
  Angiotensin Receptor Blockers Are Associated With a Lower Risk of Progression From Mild Cognitive Impairment to Dementia - Zhenhong Deng Jingru Jiang Jia Wang Dong Pan Yingying Zhu Honghong Li Xiaoni Zhang Xiaohuan Liu Yongteng Xu Yi Li Yamei Tang Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. (Z.D., J.J., J.W., D.P., Y.Z., H.L., X.Z.,X.L., Y.X., Y.L., Y.T.) Division of Clinical Research Design, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. (Y.Z., Y.T.) Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. (Y.T.) Guangdong (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Previous studies found that antihypertensive medications (AHMs) acting on the renin-angiotensin system had the potential to reduce the progression from mild cognitive impairment to dementia. However, it remains unclear whether this association differs (...) (Hypertension)
• 11:00
  Blood Pressure Intervention and Control in the SPRINT - William C. Cushman Robert J. Ringer Carlos J. Rodriguez Gregory W. Evans Jeffrey T. Bates Jeffrey A. Cutler Amret Hawfield Dalane W. Kitzman Ilya M. Nasrallah Suzanne Oparil John Nord Vasilios Papademetriou Karen Servilla Peter Van Buren Paul K. Whelton Jeff Whittle Jackson T. Wright Department of Preventive Medicine, University of Tennessee Health Science Center, and Medical Service, Veterans Affairs Medical Center, Memphis (W.C.C.). Department of Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (R.J.R.). Departments of (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:The SPRINT (Systolic Blood Pressure Intervention Trial) demonstrated reductions in major cardiovascular disease events and mortality with an intensive systolic blood pressure (SBP) goal intervention. However, a detailed description of the blood pressure (...) (Hypertension)

28 June

Hypertension https://www.ahajournals.org/

• 11:00
  Association of Blood Pressure–Related Increase in Vascular Stiffness on Other Measures of Target Organ Damage in Youth - Jessica E. Haley Shalayna A. Woodly Stephen R. Daniels Bonita Falkner Michael Ferguson Joseph T. Flynn Coral Hanevold Stephen R. Hooper Julie R. Ingelfinger Philip R. Khoury Marc B. Lande Lisa J. Martin Kevin E. Meyers Mark Mitsnefes Richard C. Becker Bernard Rosner Joshua Samuels Andrew Tran Elaine Urbina Rady Children’s Hospital San Diego, CA (J.E.H.). Cincinnati Children’s Hospital Medical Center, OH (S.A.W., P.R.K., L.J.M., M.M., R.C.B., A.T., E.U.). Children’s Hospital Colorado, Denver (S.R.D.). Thomas Jefferson University (B.F.). Boston Children’s Hospital (M.F.). Department of (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Hypertension-related increased arterial stiffness predicts development of target organ damage (TOD) and cardiovascular disease. We hypothesized that blood pressure (BP)–related increased arterial stiffness is present in youth with elevated BP and is (...) (Hypertension)
• 11:00
  Antenatal Dexamethasone Exposure Impairs Vascular Contractile Functions via Upregulating IP3 Receptor 1 and Cav1.2 in Adult Male Offspring - Ting Xu Bingyu Ji Lingjun Li Jiahui Lei Meng Zhao Miao Sun Zhice Xu Qinqin Gao Institute for Fetology, First Hospital of Soochow University, Suzhou, China (T.X., B.J., L.L., J.L., M.Z., M.S., Z.X., Q.G.). Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Administration of antenatal glucocorticoids remains common practice for treating preterm delivery. Antenatal glucocorticoid exposure increased the risk of developing vascular diseases in later life, but the precise mechanisms remain unclear. This study (...) (Hypertension)

22 June

Hypertension https://www.ahajournals.org/

• 11:00
  Voluntary Exercise Eliminates Maternal Gestational Hypertension–Induced Hypertensive Response Sensitization to Postweaning High-Fat Diet in Male Adult Offspring - Baojian Xue Yang Yu Terry G. Beltz Fang Guo Shun-Guang Wei Alan Kim Johnson Departments of Psychological and Brain Sciences, University of Iowa, Iowa City. (B.X., T.G.B., F.G., A.K.J.) Neuroscience and Pharmacology, University of Iowa, Iowa City. (A.K.J.) Health and Human Physiology, University of Iowa, Iowa City. (A.K.J.) Internal Medicine, University of Iowa, Iowa City. (Y.Y., S.-G.W.) the François M. Abboud Cardiovascular Research Center, University of Iowa, Iowa City. (S.-G.W., (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Exercise has profound effects on cardiovascular function and metabolism in both physiological and pathophysiological states. The present study tested whether voluntary exercise would protect male offspring against maternal gestational (...) (Hypertension)

21 June

Hypertension https://www.ahajournals.org/

• 11:00
  Cathepsin K Deficiency Prevented Kidney Damage and Dysfunction in Response to 5/6 Nephrectomy Injury in Mice With or Without Chronic Stress - Xueling Yue Limei Piao Hailong Wang Zhe Huang Xiangkun Meng Takeshi Sasaki Aiko Inoue Kae Nakamura Ying Wan Shengnan Xu Guo-Ping Shi Weon Kim Toyoaki Murohara Masafumi Kuzuya Xian Wu Cheng Department of Cardiology and Hypertension, Yanbian University Hospital, Yanji, Jilin, People's Republic of China (X.Y., L.P., H.W., Z.H., X.M., Y.W., S.X., X.W.C.). Department of Community Health Care and Geriatrics, Nagoya University Graduate School of Medicine, Japan. (X.Y., Z.H., X.M., M.K.) Institute of Innovation for Future Society, Nagoya University Graduate School of Medicine, Japan. (A.I., M.K.) (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Chronic psychological stress is a risk factor for kidney disease, including kidney dysfunction and hypertension. Lysosomal CatK (cathepsin K) participates in various human pathobiologies. We investigated the role of CatK in kidney remodeling and (...) (Hypertension)
• 11:00
  Digital Therapeutics in Hypertension: Evidence and Perspectives - Kazuomi Kario Noriko Harada Ayako Okura Division of Cardiovascular Medicine, School of Medicine, Jichi Medical University, Tochigi, Japan. Hypertension
  Hypertension, Ahead of Print. Digital therapeutics refers to the use of evidence-based therapeutic interventions driven by high-quality software programs to treat, manage, or prevent a medical condition. This approach is being increasingly investigated for the management of hypertension, a (...) (Hypertension)

20 June

Hypertension https://www.ahajournals.org/

• 11:00
  Variation in Mean Arterial Pressure Increases Falls Risk in Elderly Physically Frail and Prefrail Individuals Treated With Antihypertensive Medication - Sultana Monira Hussain Michael E. Ernst Anna L. Barker Karen L. Margolis Christopher M. Reid Johannes T. Neumann Andrew M. Tonkin Thao Le Thi Phuong Lawrence J Beilin Thao Pham Enayet K. Chowdhury Flavia M. Cicuttini Julia Gilmartin-Thomas Prudence R. Carr John J McNeil School of Public Health and Preventive Medicine, Monash University, Victoria, Australia (S.M.H., A.L.B., C.M.R., J.T.N., A.M.T., T.L.T.P., T.P., E.K.C., F.M.C., J.G.-T., P.R.C., J.J.M.). Department of Medical Education, Melbourne Medical School, The University of Melbourne, Victoria, Australia. (S.M.H.) Department of (...) Hypertension
  Hypertension, Ahead of Print. Background:Impaired cerebral blood flow has been associated with an increased risk of falls. Mean arterial pressure (MAP) and variability in MAP have been reported to affect cerebral blood flow but their relationships to the risk of falls have not previously been (...) (Hypertension)

16 June

Hypertension https://www.ahajournals.org/

• 11:00
  Effects of a Liquefied Petroleum Gas Stove Intervention on Gestational Blood Pressure: Intention-to-Treat and Exposure-Response Findings From the HAPIN Trial - Wenlu Ye Kyle Steenland Ashlinn Quinn Jiawen Liao Kalpana Balakrishnan Ghislaine Rosa Florien Ndagijimana Jean de Dieu Ntivuguruzwa Lisa M. Thompson John P. McCracken Anaité Díaz-Artiga Joshua P. Rosenthal Aris Papageorghiou Victor G. Davila-Roman Ajay Pillarisetti Michael Johnson Jiantong Wang Laura Nicolaou William Checkley Jennifer L. Peel Thomas F. Clasen Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA. (W.Y., K.S., A. Pillarisetti, T.F.C.) Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA. (L.M.T.) (...) Hypertension
  Hypertension, Ahead of Print. Background:Approximately 3 to 4 billion people worldwide are exposed to household air pollution, which has been associated with increased blood pressure (BP) in pregnant women in some studies.Methods:We recruited 3195 pregnant women in Guatemala, India, Peru, and (...) (Hypertension)
• 11:00
  Revascularization for Renovascular Disease: A Scientific Statement From the American Heart Association - Vivek Bhalla Stephen C. Textor Joshua A. Beckman Ana I. Casanegra Christopher J. Cooper Esther S.H. Kim James M. Luther Sanjay Misra Gustavo S. Oderich Hypertension
  Hypertension, Ahead of Print. Renovascular disease is a major causal factor for secondary hypertension and renal ischemic disease. However, several prospective, randomized trials for atherosclerotic disease failed to demonstrate that renal revascularization is more effective than medical (...) (Hypertension)
• 06:00
  Control of Blood Pressure and Risk of Cardiovascular Disease and Mortality in Elderly Chinese: A Real-World Prospective Cohort Study - Anxin Wang Xue Tian Yingting Zuo Shuohua Chen Yijun Zhang Xiaoli Zhang Xuan Deng Qin Xu Penglian Wang Shouling Wu Yong Zhou Department of Neurology, Beijing Tiantan Hospital (A.W., X.T., Y. Zuo, Y. Zhang, X.Z., Q.X., P.W.) China National Clinical Research Center for Neurological Diseases (A.W., X.T., Y. Zuo, Y. Zhang, X.Z., Q.X., P.W.) Department of Epidemiology and Health Statistics, School of Public Health (X.T., Y. Zuo) Capital Medical University. Beijing Municipal Key Laboratory of Clinical Epidemiology, China (X.T., Y. Zuo). Department of Cardiology, Kailuan Hospital, North China (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:The STEP trial (Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients) showed that older hypertensive patients might benefit from a target systolic blood pressure (SBP) of 110 (...) (Hypertension)

15 June

Hypertension https://www.ahajournals.org/

• 11:00
  SGLT2 Inhibition via Empagliflozin Improves Endothelial Function and Reduces Mitochondrial Oxidative Stress: Insights From Frail Hypertensive and Diabetic Patients - Pasquale Mone Fahimeh Varzideh Stanislovas S. Jankauskas Antonella Pansini Angela Lombardi Salvatore Frullone Gaetano Santulli Asl Avellino, Albert Einstein College of Medicine, New York, NY. (P.M., A.P., S.F.). Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, New York, NY. (P.M., F.V., S.S.J., A.L., G.S.) Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY. (G.S.) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Frailty is a multidimensional condition often diagnosed in older adults with hypertension and diabetes, and both these conditions are associated with endothelial dysfunction and oxidative stress. We investigated the role of the SGLT2 (sodium glucose (...) (Hypertension)

13 June

Hypertension https://www.ahajournals.org/

• 11:00
  Per- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women's Health Across the Nation - Ning Ding Carrie A. Karvonen-Gutierrez Bhramar Mukherjee Antonia M. Calafat Siobán D. Harlow Sung Kyun Park Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor. (N.D., C.A.K.-G., S.D.H., S.K.P.) Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor. (B.M.) Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor. (S.K.P.) Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA (...) Hypertension
  Hypertension, Ahead of Print. Background:Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are ubiquitous synthetic chemicals that may disrupt blood pressure controls; however, human evidence to support this hypothesis is scant. We examined the association between serum concentrations of (...) (Hypertension)

10 June

Hypertension https://www.ahajournals.org/

• 11:00
  Management and Outcomes of Primary Aldosteronism in Pregnancy: A Systematic Review - Viola Sanga Giacomo Rossitto Teresa Maria Seccia Gian Paolo Rossi Hypertension and Emergency Unit, Department of Medicine - DIMED, University of Padua, Italy. (V.S., T.M.S., G.P.R.) PhD Arterial Hypertension and Vascular Biology, Department of Medicine - DIMED, University of Padua, Italy. (V.S.) Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (G.R.). Hypertension
  Hypertension, Ahead of Print. Primary aldosteronism (PA) in pregnancy (PAP) can be a serious condition and is challenging to diagnose. This study was conceived to help in the diagnosis of PAP and provide suggestions on management of PAP based on evidence retrieved using a Population, (...) (Hypertension)
• 11:00
  IsoLGs (Isolevuglandins) Drive Neutrophil Migration in Hypertension and Are Essential for the Formation of Neutrophil Extracellular Traps - Jaya Krishnan Néstor de la Visitación Elizabeth M. Hennen Venkataraman Amarnath David G. Harrison David M. Patrick Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center. (J.K., N.d.l.V., V.A., D.G.H., D.M.P.) Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center. (D.G.H., D.M.P.) Department of Biomedical Engineering, Vanderbilt University (E.M.H.). Department of Veterans Affairs, Nashville, TN (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:IsoLGs (isolevuglandins) are electrophilic products of lipid peroxidation formed in the presence of reactive oxygen species. IsoLGs contribute to hypertension by an unknown mechanism. Studies have shown that reactive oxygen species production drives the (...) (Hypertension)
• 11:00
  Effects of Ramipril on Biomarkers of Endothelial Dysfunction and Inflammation in Hypertensive Children on Maintenance Hemodialysis: the SEARCH Randomized Placebo-Controlled Trial - Areej Mohamed Ateya Ihab El Hakim Sara Mahmoud Shahin Radwa El Borolossy Reinhold Kreutz Nagwa Ali Sabri Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.M.A., S.M.S., R.E.B., N.A.S.). Charité – Universitätsmedizin Berlin, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany (A.M.A., R.K.). Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt (I.E.H.). Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Hypertension, endothelial dysfunction, and inflammation are associated with increased cardiovascular mortality in end-stage kidney disease. We evaluated the effects of ACE (angiotensin-converting enzyme) inhibition on biomarkers of endothelial (...) (Hypertension)

8 June

Hypertension https://www.ahajournals.org/

• 11:00
  Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na+/H+ Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway - Xiaoliang Jiang Yunpeng Liu Xin-Yang Zhang Xue Liu Xing Liu Xianxian Wu Pedro A. Jose Shun Duan Fu-Jian Xu Zhiwei Yang NHC Key Laboratory of Human Disease Comparative Medicine (The Institute of Laboratory Animal Sciences, CAMS&PUMC), National Human Diseases Animal Model Resource Center, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, P.R. China (X.J., Y.L., Xue Liu, Xing Liu, X.W., Z.Y.). Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education, Beijing Laboratory of (...) Hypertension
  Hypertension, Ahead of Print. Background:The present study directly tested the crucial role of intestinal gastrin/CCKBR (cholecystokinin B receptor) in the treatment of salt-sensitive hypertension.Methods:Adult intestine-specificCckbr-knockout mice (Cckbrfl/flvillin-Cre) and Dahl salt-sensitive (...) (Hypertension)
• 11:00
  Association Between the Gut Microbiome and Their Metabolites With Human Blood Pressure Variability - Evany Dinakis Michael Nakai Paul Gill Rosilene Ribeiro Stephanie Yiallourou Yusuke Sata Jane Muir Melinda Carrington Geoffrey A. Head David M. Kaye Francine Z. Marques Hypertension Research Laboratory, School of Biological Sciences, Monash University, Melbourne, Australia. (E.D., M.N.) Department of Gastroenterology, Monash University, Melbourne, Australia. (P.G., J.M.) Central Clinical School, Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, Australia. (Y.S., D.M.K.) Department of Pharmacology, Faculty of Medicine Nursing and Health Sciences, Monash (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Blood pressure (BP) variability is an independent risk factor for cardiovascular events. Recent evidence supports a role for the gut microbiota in BP regulation. However, whether the gut microbiome is associated with BP variability is yet to be (...) (Hypertension)
• 08:00
  Correction to: Prospective Evaluation of International Prediction of Pregnancy Complications Collaborative Network Models for Prediction of Preeclampsia: Role of Serum sFlt-1 at 11–13 Weeks’ Gestation Hypertension
  Hypertension, Volume 79, Issue 7, Page e113-e113, July 1, 2022. (Hypertension)
• 11:00
  MANP (Mutant Atrial Natriuretic Peptide) Activation of the cGMP (3’,5’, Cyclic Guanosine Monophosphate) Inhibits Aldosterone via PDE2 (Phosphodiesterase 2) and Cytochrome p450 Family 11 Subfamily b Member 2 in H295R Cells and in Mice - Yang Chen Seethalakshmi R. Iyer Viacheslav O. Nikolaev Fabio Naro Manuela Pellegrini Silvia Cardarelli Xiao Ma Hon-Chi Lee John C. Burnett Cardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester MN. (Y.C., S.R.I., X.M., J.C.B.) Department of Cardiovascular Medicine, Mayo Clinic, Rochester MN. (H.-C.L.) Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia (Y.C.). Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Germany (V.O.N.). Department of Anatomical, Histological, (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Aldosterone is a critical pathological driver for cardiac and renal diseases. We recently discovered that MANP (mutant atrial natriuretic peptide), a novel ANP (atrial natriuretic peptide) analog, possessed more potent aldosterone inhibitory action than (...) (Hypertension)

6 June

Hypertension https://www.ahajournals.org/

• 11:00
  Uric Acid and Hypertension: a Review of Evidence and Future Perspectives for the Management of Cardiovascular Risk - Claudio Borghi Davide Agnoletti Arrigo Francesco Giuseppe Cicero Empar Lurbe Agostino Virdis Department of Medical and Surgical Science-IRCCS S.Orsola, University of Bologna, Italy (C.B., D.A., A.F.G.C.). Department of Pediatrics, University of Valencia, Spain (E.L.). Department of Clinical and Experimental Medicine, University of Pisa, Italy (A.V.). Hypertension
  Hypertension, Ahead of Print. Uric acid is the final product of purine metabolism, and its increased serum levels have been directly involved in the pathogenesis and natural history of hypertension. The relationship between elevated uric acid and hypertension has been proven in both animals and (...) (Hypertension)

3 June

Hypertension https://www.ahajournals.org/

• 11:00
  Effect of Renin-Angiotensin-Aldosterone System Inhibitors on the Rupture Risk Among Hypertensive Patients With Intracranial Aneurysms - Ping Zhong Zhiwen Lu Zhangyu Li Tianxiao Li Qing Lan Jianmin Liu Zhanxiang Wang Sifang Chen Qinghai Huang Department of Neurosurgery (P.Z., Z. Li, S.C.), School of Medicine, Xiamen University, China. BE and Phase I Clinical Trial Center (P.Z.), School of Medicine, Xiamen University, China. Department of Neurosurgery, Xiamen Key Laboratory of Brain Center (Z.W.), School of Medicine, Xiamen University, China. The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University and Department of Neuroscience, Institute of Neurosurgery (Z.W.), School of Medicine, Xiamen (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1475-1486, July 1, 2022. Background:Mounting experimental evidence supports the concept that the RAAS (renin-angiotensin-aldosterone system) is involved in the pathogenesis of intracranial aneurysm rupture. However, whether RAAS inhibitors could reduce the (...) (Hypertension)
• 11:00
  Uric Acid Expression in Carotid Atherosclerotic Plaque and Serum Uric Acid Are Associated With Cerebrovascular Events - Valentina Nardi Federico Franchi Megha Prasad Erica M. Fatica Mariam P. Alexander Melanie C. Bois Josephine Lam Ravinder J. Singh Fredric B. Meyer Giuseppe Lanzino Yuning Xiong Esther Lutgens Lilach O. Lerman Amir Lerman Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. (V.N., F.F., M.P., J.L., Y.X., E.L., A.L.) Department of Laboratory of Medicine and Pathology, Mayo Clinic, Rochester, MN. (E.M.F., M.P.A., M.C.B., R.J.S.) Department of Neurosurgery, Mayo Clinic, Rochester, MN. (F.B.M., G.L.) Department of Nephrology and Hypertension, Mayo Clinic, Rochester, MN. (...) Hypertension
  Hypertension, Ahead of Print. Background:Uric acid (UA) concentration within carotid plaque and its association with cerebrovascular events have not been detected or quantified. Systemically, serum UA is a marker of inflammation and risk factor for atherosclerosis. However, its association with (...) (Hypertension)

2 June

Hypertension https://www.ahajournals.org/

• 11:01
  Novel Drug Delivery Technologies and Targets for Renal Disease - Alejandro R. Chade Gene L. Bidwell The Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson. (A.R.C.) the Department of Medicine, University of Mississippi Medical Center, Jackson. (A.R.C.) the Department of Radiology, University of Mississippi Medical Center, Jackson. (A.R.C.) the Department of Neurology, University of Mississippi Medical Center, Jackson. (G.L.B.) the Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson. (G.L.B.) the Department of Pharmacology, University of Mississippi Medical Center, Jackson. (...) Hypertension
  Hypertension, Ahead of Print. The burden of acute and chronic kidney diseases to the health care system is exacerbated by the high mortality that this disease carries paired with the still limited availability of comprehensive therapies. A reason partially resides in the complexity of the (...) (Hypertension)
• 11:01
  Performance of Confirmatory Tests for Diagnosing Primary Aldosteronism: a Systematic Review and Meta-Analysis - Alexander A. Leung Christopher J. Symonds Gregory L. Hundemer Paul E. Ronksley Diane L. Lorenzetti Janice L. Pasieka Adrian Harvey Gregory A. Kline Division of Endocrinology and Metabolism, Department of Medicine (A.A.L., C.J.S., G.A.K.), University of Calgary, AB. Department of Community Health Sciences (A.A.L., P.E.R., D.L.L.), University of Calgary, AB. Department of Surgery (J.L.P., A.H.), University of Calgary, AB. Department of Oncology (J.L.P., A.H.), University of Calgary, AB. Division of Nephrology, Department of Medicine and the Ottawa Hospital Research Institute, University of (...) Hypertension
  Hypertension, Ahead of Print. Background:Confirmatory tests are recommended for diagnosing primary aldosteronism, but the supporting evidence is unclear.Methods:We searched Medline, EMBASE, and the Cochrane Central Register of Controlled Trials. Studies evaluating any guideline-recommended (...) (Hypertension)
• 11:00
  Dapagliflozin Attenuates Sympathetic and Pressor Responses to Stress in Young Prehypertensive Spontaneously Hypertensive Rats - Han-Kyul Kim Rie Ishizawa Ayumi Fukazawa Zhongyun Wang Ursa Bezan Petric Ming Chang Hu Scott A. Smith Masaki Mizuno Wanpen Vongpatanasin Departments of Internal Medicine-Hypertension Section, University of Texas Southwestern Medical Center, Dallas. (H.-K.K., Z.W., U.B.P., W.V.) Applied Clinical Research, University of Texas Southwestern Medical Center, Dallas. (H.-K.K., R.I., A.F., S.A.S., M.M.) Internal Medicine-Renal Division, University of Texas Southwestern Medical Center, Dallas. (M.C.H.) Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical (...) Hypertension
  Hypertension, Ahead of Print. Background:SGLT2i (sodium-glucose cotransporter 2 inhibitor), a class of anti-diabetic medications, is shown to reduce blood pressure (BP) in hypertensive patients with type 2 diabetes. Mechanisms underlying this action are unknown but SGLT2i-induced (...) (Hypertension)
• 11:00
  Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension - Tanika N. Kelly Xiao Sun Karen Y. He Michael R. Brown Sarah A. Gagliano Taliun Jacklyn N. Hellwege Marguerite R. Irvin Xuenan Mi Jennifer A. Brody Nora Franceschini Xiuqing Guo Shih-Jen Hwang Paul S. de Vries Yan Gao Arden Moscati Girish N. Nadkarni Lisa R. Yanek Tali Elfassy Jennifer A. Smith Ren-Hua Chung Amber L. Beitelshees Amit Patki Stella Aslibekyan Brandon M. Blobner Juan M. Peralta Themistocles L. Assimes Walter R. Palmas Chunyu Liu Adam P. Bress Zhijie Huang Lewis C. Becker Chii-Min Hwa Jeffrey R. O’Connell Jenna C. Carlson Helen R. Warren Sayantan Das Ayush Giri Lisa W. Martin (...) Hypertension
  Hypertension, Ahead of Print. Background:The availability of whole-genome sequencing data in large studies has enabled the assessment of coding and noncoding variants across the allele frequency spectrum for their associations with blood pressure.Methods:We conducted a multiancestry (...) (Hypertension)
• 11:00
  Longitudinal Changes in Cardiac Structure and Function in Pediatric Kidney Transplant Recipients - Isabel de Verteuil Jessica Fitzpatrick Ana Catalina Alvarez Elias Tonny Banh Jovanka Vasilevska-Ristovska Jordan Browne Bianca C. Bondi Wei Hui Cameron Slorach Chia Wei Teoh Valerie Langlois Luc Mertens Rulan S. Parekh Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children. (I.d.V., J.F., A.C.A.E., T.B., J.V.-R., J.B., B.C.B., C.W.T., R.S.P.) Labatt Family Heart Center, The Hospital for Sick Children. (W.H., C.S., L.M.) Division of Nephrology, The Hospital for Sick Children and University Health Network (A.C.A.E., C.W.T., V.L., R.S.P.). Institute of Health (...) Hypertension
  Hypertension, Ahead of Print. Background:Cardiovascular disease results in increased morbidity and mortality in pediatric kidney transplant recipients. Longitudinal changes in cardiac structure and function and the association with blood pressure control over time in pediatric kidney transplant (...) (Hypertension)

31 May

Hypertension https://www.ahajournals.org/

• 11:00
  How to Improve Awareness, Treatment, and Control of Hypertension in Africa, and How to Reduce Its Consequences. A Call to Action From the World Hypertension League - Gianfranco Parati Daniel T. Lackland Norman R.C. Campbell Mayowa Ojo Owolabi Charlotte Bavuma Hind Mamoun Beheiry Anastase Dzudie Moshen Ibrahim Wafaa El Aroussy Sandhya Singh Cherian V. Varghese Paul K. Whelton Xin-Hua Zhang Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular Neural and Metabolic Sciences; and Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy (G.P.). Division of Translational Neurosciences and Population Studies, Medical University of South Carolina, Charleston (D.T.L.). Department of Medicine, Physiology and Pharmacology and (...) Hypertension
  Hypertension, Ahead of Print. Hypertension is the leading preventable risk factor for cardiovascular diseases and disability globally. In low- and middle-income countries hypertension has a major social impact, increasing the disease burden and costs for national health systems. The present (...) (Hypertension)

26 May

Hypertension https://www.ahajournals.org/

• 11:00
  Blood Pressure Control Among US Adults, 2009 to 2012 Through 2017 to 2020 - Paul Muntner Miriam A. Miles Byron C. Jaeger Lonnie Hannon Shakia T. Hardy Yechiam Ostchega Gregory Wozniak Joseph E. Schwartz Department of Epidemiology, University of Alabama at Birmingham. (P.M., S.T.H.) Department of Health Behavior, University of Alabama at Birmingham. (M.A.M., L.H.) Department of Biostatistics, Wake Forest University, Winston Salem, NC (B.C.J.). School of Nursing, Johns Hopkins University, Baltimore, MD (Y.O.). American Medical Association, Chicago, IL (G.W.). Department of Medicine, Columbia University Irving Medical Center, New York, NY (J.E.S.). Department of (...) Hypertension
  Hypertension, Ahead of Print. Background:The National Health and Nutrition Examination Survey data indicate that the proportion of US adults with hypertension that had controlled blood pressure (BP) declined from 2013 to 2014 through 2017 to 2018. We analyzed data from National Health and (...) (Hypertension)

24 May

Hypertension https://www.ahajournals.org/

• 11:00
  Effects of Blood Pressure According to Age on End-Stage Renal Disease Development in Patients With Patients With Diabetes: A Nationwide Population-Based Cohort Study - Eun Hui Bae Sang Yeob Lim Bongseong Kim Tae Ryom Oh Su Hyun Song Sang Heon Suh Hong Sang Choi Eun Mi Yang Chang Seong Kim Seong Kwon Ma Kyung-Do Han Soo Wan Kim From the Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. (E.H.B., T.R.O., S. Hyun Song, S. Heon Suh, H.S.C., C.S.K., S.K.M., S.W.K.) Department of Pediatrics, Chonnam National University Medical School, Gwangju, Korea. (E.M.Y.) Department of Internal Medicine, Korea University Ansan Hospital (S.Y.L.). Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea (...) Hypertension
  Hypertension, Ahead of Print. Background:Recent hypertension guidelines have recommended lower blood pressure (BP) targets in high-risk patients. However, there are no specific guidelines based on age or systolic and diastolic blood pressure (SBP and DBP, respectively). We aimed to assess the (...) (Hypertension)
• 11:00
  Evidence From Human Placenta, Endoplasmic Reticulum–Stressed Trophoblasts, and Transgenic Mice Links Transthyretin Proteinopathy to Preeclampsia - Shibin Cheng Zheping Huang Sayani Banerjee Sukanta Jash Joel N. Buxbaum Surendra Sharma Department of Pediatrics, Women & Infants Hospital, Warren Alpert Medical School of Brown University, Providence, RI (S.C., Z.H., S.B., S.J., S.S.). Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA (J.N.B.). Protego Biopharma, Inc, San Diego, CA (J.N.B.). Hypertension
  Hypertension, Ahead of Print. Background:We have demonstrated that protein aggregation plays a pivotal role in the pathophysiology of preeclampsia and identified several aggregated proteins in the circulation of preeclampsia patients, the most prominent of which is the serum protein TTR (...) (Hypertension)

23 May

Hypertension https://www.ahajournals.org/

• 11:00
  Ambulatory Blood Pressure Monitoring in Children and Adolescents: 2022 Update: A Scientific Statement From the American Heart Association - Joseph T. Flynn Elaine M. Urbina Tammy M. Brady Carissa Baker-Smith Stephen R. Daniels Laura L. Hayman Mark Mitsnefes Andrew Tran Justin P. Zachariah Hypertension
  Hypertension, Volume 79, Issue 7, Page e114-e124, July 1, 2022. Use of ambulatory blood pressure monitoring in children and adolescents has markedly increased since publication of the last American Heart Association scientific statement on pediatric ambulatory blood pressure monitoring in 2014. (...) (Hypertension)
• 11:00
  Markers of Focal and Diffuse Nonischemic Myocardial Fibrosis Are Associated With Adverse Cardiac Remodeling and Prognosis in Patients With Hypertension: The REMODEL Study - Nithin R. Iyer Thu-Thao Le Michelle S.L. Kui Hak-Chiaw Tang Chee-Tang Chin Soon-Kieng Phua Jennifer A. Bryant Chee-Jian Pua Briana Ang Desiree-Faye Toh Tar-Choon Aw Chi-Hang Lee Stuart A. Cook Martin Ugander Calvin W.L. Chin Department of Cardiology, National Heart Centre Singapore (N.R.I., T.-T.L., M.S.L.K., H.-C.T., C.-T.C., J.A.B., S.A.C., C.W.L.C.). National Heart Research Institute Singapore (T.-T.L., J.A.B., C.-J.P., B.A., D.-F.T., S.A.C., C.W.L.C.). Cardiovascular ACP, Duke-NUS Medical School, Singapore (T.-T.L., C.W.L.C.). Department of Laboratory Medicine, Changi General (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:The prognostic significance of focal and diffuse myocardial fibrosis in patients with cardiovascular risk factors is unclear.METHODS:REMODEL (Response of the Myocardium to Hypertrophic Conditions in the Adult Population) is an observational cohort of (...) (Hypertension)
• 11:00
  Is It Time to Drop Unclassified Category in Pediatric Ambulatory Blood Pressure Monitoring? - Fallon Campbell Shweta Shah Poyyapakkam Srivaths Katharine Sigler Alisa A. Acosta Pediatrics, Renal Section, Baylor College of Medicine, Texas Children’s Hospital, Houston. Hypertension
  Hypertension, Ahead of Print. (Hypertension)

19 May

Hypertension https://www.ahajournals.org/

• 11:01
  Reshaping the Preterm Heart: Shifting Cardiac Renin-Angiotensin System Towards Cardioprotection in Rats Exposed to Neonatal High-Oxygen Stress - Mariane Bertagnolli Daniela R. Dartora Pablo Lamata Ernesto Zacur Thuy-An Mai Vo Ying He Léonie Beauchamp Adam J. Lewandowski Anik Cloutier Megan R. Sutherland Robson A.S. Santos Anne Monique Nuyt Sainte-Justine University Hospital Research Center, Université de Montréal, Canada (M.B., D.R.D., T.-A.M.V., Y.H., L.B., A.C., M.R.S., A.M.N.). Research Center of the Hospital Sacré-Coeur, CIUSSS Nord-de-l’Île-de-Montréal, Canada (M.B.). School of Physical and Occupational Therapy, Faculty of Medicine, McGill University, Montréal, Canada (M.B.). Instituto de Cardiologia de Porto Alegre, Fundação (...) Hypertension
  Hypertension, Ahead of Print. Background:Approximately 10% of infants are born preterm. Preterm birth leads to short and long-term changes in cardiac shape and function. By using a rat model of neonatal high-oxygen (80%O2) exposure, mimicking the premature hyperoxic transition to the (...) (Hypertension)
• 11:00
  Puberty Timing and Sex-Specific Trajectories of Systolic Blood Pressure: a Prospective Cohort Study - Kate N. O’Neill Joshua A. Bell George Davey Smith Kate Tilling Patricia M. Kearney Linda M. O’Keeffe School of Public Health, University College Cork, Ireland (K.N.O., P.M.K., L.M.O.). MRC Integrative Epidemiology Unit at the University of Bristol, United Kingdom (J.A.B., G.D.S., K.T., L.M.O.). Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom (J.A.B., G.D.S., K.T., L.M.O.). Hypertension
  Hypertension, Ahead of Print. Background:Sex differences in systolic blood pressure (SBP) emerge during adolescence but the role of puberty is not well understood. We examined sex-specific changes in SBP preceding and following puberty and examined the impact of puberty timing on SBP (...) (Hypertension)

18 May

Hypertension https://www.ahajournals.org/

• 11:01
  Twenty-Four-Hour Pulsatile Hemodynamics Predict Brachial Blood Pressure Response to Renal Denervation in the SPYRAL HTN-OFF MED Trial - Thomas Weber Siegfried Wassertheurer Christopher C. Mayer Bernhard Hametner Kathrin Danninger Raymond R. Townsend Felix Mahfoud Kazuomi Kario Martin Fahy Vanessa DeBruin Nicole Peterson Manuela Negoita Michael A. Weber David E. Kandzari Roland E. Schmieder Konstantinos P. Tsioufis Ronald K. Binder Michael Böhm Cardiology Department, Klinikum Wels-Grieskirchen, Austria (T.W., K.D., R.K.B.). AIT - Austrian Institute of Technology, Vienna, Austria (S.W., C.C.M., B.H.). Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.R.T.). Klinik für Innere Medizin III, (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1506-1514, July 1, 2022. Background:Renal denervation (RDN) lowers blood pressure (BP), but BP response is variable in individual patients. We investigated whether measures of pulsatile hemodynamics, obtained during 24-hour ambulatory BP monitoring, (...) (Hypertension)
• 11:00
  Cardiac Structure and Function Across the Spectrum of Aldosteronism: the Atherosclerosis Risk in Communities Study - Jenifer M. Brown Magnus O. Wijkman Brian L. Claggett Amil M. Shah Christie M. Ballantyne Josef Coresh Morgan E. Grams Zhiying Wang Bing Yu Eric Boerwinkle Anand Vaidya Scott D. Solomon Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA. (J.M.B., M.O.W., B.L.C., A.M.S., S.D.S.) Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension (A.V.) Departments of Internal Medicine and Health, Medicine and Caring Sciences, Linköping University, Norrköping, Sweden (M.O.W.). Center for Cardiometabolic Disease Prevention, Baylor College of Medicine, (...) Hypertension
  Hypertension, Ahead of Print. Background:Aldosterone production and mineralocorticoid receptor activation are implicated in myocardial fibrosis and cardiovascular events.Methods:Cardiac structure and function were assessed in 4547 participants without prevalent heart failure (HF) in the ARIC (...) (Hypertension)
• 11:00
  Evolving Concepts in Endothelial Pathobiology of Pulmonary Arterial Hypertension - Nicholas D. Cober M. Martin VandenBroek Mark L. Ormiston Duncan J. Stewart Ottawa Hospital Research Institute, ON, Canada (N.D.C., D.J.S.). Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, ON, Canada (N.D.C., D.J.S.). Department of Medicine, Queen’s University, Kingston, ON, Canada (M.M.V., M.L.O.). Departments of Surgery, and Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada (M.L.O.). Hypertension
  Hypertension, Ahead of Print. Pulmonary arterial hypertension (PAH) is a deadly disease, characterized by increased vascular resistance, pulmonary arteriolar loss, and occlusive arterial remodeling, leading to eventual right heart failure. Evidence increasingly points to the pulmonary (...) (Hypertension)

17 May

Hypertension https://www.ahajournals.org/

• 11:00
  Global Impact of Different Blood Pressure Thresholds in 4 021 690 Participants of the May Measurement Month Initiative - Janis M. Nolde Thomas Beaney Revathy Carnagarin Aletta E. Schutte Neil R. Poulter Markus P. Schlaich Dobney Hypertension Centre, Medical School–Royal Perth Hospital Unit/RPH Research Foundation, University of Western Australia, Australia (J.M.N., R.C., M.P.S.). Imperial Clinical Trials Unit, Imperial College London, United Kingdom (T.B., N.R.P.). School of Population Health, University of New South Wales, Sydney, Australia (A.E.S.). George Institute for Global Health, Sydney, NSW, Australia (A.E.S.). Hypertension in Africa Research Team, Medical Research Council Unit for Hypertension and (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1497-1505, July 1, 2022. Background:Influential guidelines currently define hypertension at different thresholds of blood pressure (BP). The global May Measurement Month initiative provides a unique opportunity to estimate the potential consequences of (...) (Hypertension)

16 May

Hypertension https://www.ahajournals.org/

• 11:00
  Hypertension, Arterial Stiffness, and Diabetes: a Prospective Cohort Study - Xue Tian Yingting Zuo Shuohua Chen Yijun Zhang Xiaoli Zhang Qin Xu Shouling Wu Anxin Wang Department of Neurology (X.T., Y.Z., Y.Z., X.Z., Q.X., A.W.), Beijing Tiantan Hospital, Capital Medical University, China. China National Clinical Research Center for Neurological Diseases (X.T., Y.Z., Y.Z., X.Z., Q.X., A.W.), Beijing Tiantan Hospital, Capital Medical University, China. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China (X.T., Y.Z.). Beijing Municipal Key Laboratory of Clinical Epidemiology, China (X.T., Y.Z.). (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1487-1496, July 1, 2022. Background:Whether the combination of different blood pressure and arterial stiffness (AS) status is independently associated with diabetes has not been fully investigated so far. This study aimed at investigating the status of (...) (Hypertension)
• 11:00
  Inverse Association of Skin Temperature With Ambulatory Blood Pressure and the Mediation of Skin Temperature in Blood Pressure Responses to Ambient Temperature - Yoshiaki Tai Kenji Obayashi Yuki Yamagami Keigo Saeki Department of Epidemiology, Nara Medical University School of Medicine, Japan. Hypertension
  Hypertension, Ahead of Print. BACKGROUND:The inverse association between ambient temperature and blood pressure (BP) has been investigated in the context of excess cardiovascular mortality in winter. However, the role of skin temperature (ST), which reflects our external and internal thermal (...) (Hypertension)

13 May

Hypertension https://www.ahajournals.org/

• 06:00
  Sex-Related Signaling of Aldosterone/Mineralocorticoid Receptor Pathway in Calcific Aortic Stenosis - Lara Matilla Eva Jover Mattie Garaikoetxea Ernesto Martín-Nuñez Vanessa Arrieta Amaia García-Peña Adela Navarro Amaya Fernández-Celis Alicia Gainza Virginia Álvarez Diego Álvarez de la Rosa Rafael Sádaba Frederic Jaisser Natalia López-Andrés Cardiovascular Translational Research, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain (L.M., E.J., M.G., E.M.-N., V.A., A.G.-P., A.N., A.F.-C., A.G., V.A., R.S., N.L.-A.). Department of Physiology, Institute of Biomedical Technology, University of Laguna, La Laguna, Spain (D.A.d.l.R.). (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:There are sex differences in the pathophysiology of aortic valve (AV) calcification in patients with aortic stenosis, although the molecular and cellular mechanisms have not been elucidated. Aldosterone (Aldo) promotes proteoglycan synthesis in valve (...) (Hypertension)

12 May

Hypertension https://www.ahajournals.org/

• 11:00
  Performance of a Multianalyte ‘Rule-Out’ Assay in Pregnant Individuals With Suspected Preeclampsia - Maged M. Costantine Baha Sibai Allan T. Bombard Mark Sarno Holly West David M. Haas Alan T. Tita Michael J. Paidas Erin A.S. Clark Kim Boggess Chad Grotegut William Grobman Emily J Su Irina Burd George Saade Martin R. Chavez Michael J. Paglia Audrey Merriam Carlos Torres Mounira Habli Georges Macones Tony Wen James Bofill Anna Palatnik Rodney K. Edwards Sina Haeri Pankaj Oberoi Amin Mazloom Matthew Cooper Steven Lockton Gary D. Hankins Departments of Obstetrics and Gynecology of The Ohio State University, Columbus (M.M.C). The University of Texas Health Sciences Houston (B.S). NVB (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1515-1524, July 1, 2022. Background:The ability to diagnose preeclampsia clinically is suboptimal. Our objective was to validate a novel multianalyte assay and characterize its performance, when intended for use as an aid to rule-out (...) (Hypertension)
• 11:00
  Sex Differences in Diurnal Sodium Handling During Diet-Induced Obesity in Rats - Reham H. Soliman Chunhua Jin Crystal M. Taylor Emile Moura Coelho da Silva David M. Pollock Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham. Hypertension
  Hypertension, Volume 79, Issue 7, Page 1395-1408, July 1, 2022. Background:Emerging evidence over the past several years suggests that diurnal control of sodium excretion is sex dependent and involves the renal endothelin system. Given recent awareness of disruptions of circadian function in (...) (Hypertension)
• 11:00
  The Immune System in Hypertension: a Lost Shaker of Salt 2021 Lewis K. Dahl Memorial Lecture - Xiaohan Lu Steven D. Crowley Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, NC. Hypertension
  Hypertension, Volume 79, Issue 7, Page 1339-1347, July 1, 2022. The seminal observations of Dr Lewis Dahl regarding renal mechanisms of hypertension remain highly relevant in light of more recent experiments showing that immune system dysfunction contributes to hypertension pathogenesis. Dr (...) (Hypertension)

11 May

Hypertension https://www.ahajournals.org/

• 11:00
  Disintegrin and Metalloproteinases (ADAMs [A Disintegrin and Metalloproteinase] and ADAMTSs [ADAMs With a Thrombospondin Motif]) in Aortic Aneurysm - Tolga Kilic Keisuke Okuno Satoru Eguchi Zamaneh Kassiri Department of Physiology, Cardiovascular Research Center, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada (T.K., Z.K.). Cardiovascular Research Center and Department of Cardiovascular Science, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (K.O., S.E.). Hypertension
  Hypertension, Volume 79, Issue 7, Page 1327-1338, July 1, 2022. Aortic aneurysm is a complex pathology that can be lethal if not detected in time. Although several molecular mechanisms and pathways have been identified to be involved in aortic aneurysm development and growth, the current lack (...) (Hypertension)
• 08:00
  Carotid Intima-Media Thickness Is Associated With Obesity and Hypertension in Young People - Angela K. Lucas-Herald Christian Delles Developmental Endocrinology Research Group, School of Medicine, Dentistry and Nursing, University of Glasgow (A.K.L.-H.), University of Glasgow, United Kingdom. Institute of Cardiovascular and Medical Sciences, British Heart Foundation Centre for Research Excellence (A.K.L.-H., C.D.), University of Glasgow, United Kingdom. Hypertension
  Hypertension, Volume 79, Issue 6, Page 1177-1179, June 1, 2022. (Hypertension)
• 08:00
  Correction to: Inverse Association Between Riboflavin Intake and New-Onset Hypertension: A Nationwide Cohort Study in China Hypertension
  Hypertension, Volume 79, Issue 6, Page e110-e110, June 1, 2022. (Hypertension)
• 08:00
  Correction to: Occupational Physical Activity and New-Onset Hypertension: A Nationwide Cohort Study in China Hypertension
  Hypertension, Volume 79, Issue 6, Page e109-e109, June 1, 2022. (Hypertension)
• 06:00
  Identification of a Gut Commensal That Compromises the Blood Pressure-Lowering Effect of Ester Angiotensin-Converting Enzyme Inhibitors - Tao Yang Xue Mei Ethel Tackie-Yarboi Millicent Tambari Akere Jun Kyoung Blair Mell Ji-Youn Yeo Xi Cheng Jasenka Zubcevic Elaine M. Richards Carl J. Pepine Mohan K. Raizada Isaac T. Schiefer Bina Joe Department of Physiology and Pharmacology, College of Medicine and Life Sciences, University of Toledo, OH. (T.Y., X.M., J.K., B.M., J.-Y.Y., X.C., J.Z., B.J.) UT Microbiome Consortium, Center for Hypertension and Precision Medicine, University of Toledo, OH. (T.Y., X.M., B.M., J.-Y.Y., X.C., J.Z., B.J.) Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical (...) Hypertension
  Hypertension, Ahead of Print. Background:Despite the availability of various classes of antihypertensive medications, a large proportion of hypertensive individuals remain resistant to treatments. The reason for what contributes to low efficacy of antihypertensive medications in these (...) (Hypertension)

10 May

Hypertension https://www.ahajournals.org/

• 11:00
  Separate and Joint Associations of Cardiorespiratory Fitness and Healthy Vascular Aging With Subclinical Atherosclerosis in Men - Sae Young Jae Kyung Hyun Lee Hyun Jeong Kim Setor K. Kunutsor Kevin S. Heffernan Rachel E. Climie Kanokwan Bunsawat Mira Kang Department of Sport Science (S.Y.J., H.J.K.), University of Seoul, Republic of Korea. Division of Urban Social Health, Graduate School of Urban Public Health (S.Y.J.), University of Seoul, Republic of Korea. Department of Digital Health, SAIHST, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (K.H.L., M.K.). National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1445-1454, July 1, 2022. Background:Achieving healthy vascular aging (HVA) is important for decelerating age-related cardiovascular disease risk. We evaluated the interplay between HVA, cardiorespiratory fitness (CRF), and subclinical (...) (Hypertension)
• 11:00
  Differences in Regulation of Cortisol Secretion Contribute to Left Ventricular Abnormalities in Patients With Essential Hypertension - Gabriele Brosolo Cristiana Catena Andrea Da Porto Luca Bulfone Antonio Vacca Nicolas D. Verheyen Leonardo A. Sechi Hypertension Unit, Division of Internal Medicine, Department of Medicine, University of Udine, Udine, Italy (G.B., C.C., A.D.P., L.B., A.V., L.A.S.). Department of Cardiology, Medical University of Graz, Austria (N.D.V.). Hypertension
  Hypertension, Volume 79, Issue 7, Page 1435-1444, July 1, 2022. Background:Left ventricular (LV) abnormalities were reported in patients with overt and subclinical Cushing syndrome. The aim of this study was to investigate the relationships of daily plasma cortisol profile and cortisol response (...) (Hypertension)
• 06:00
  Chronic Hypoxia in Ovine Pregnancy Recapitulates Physiological and Molecular Markers of Preeclampsia in the Mother, Placenta, and Offspring - Wen Tong Beth J. Allison Kirsty L. Brain Olga V. Patey Youguo Niu Kimberley J. Botting Sage G. Ford Tessa A. Garrud Peter F.B. Wooding Caroline J. Shaw Qiang Lyu Lin Zhang Jin Ma Tereza Cindrova-Davies Hong Wa Yung Graham J. Burton Dino A. Giussani Department of Physiology Development & Neuroscience, University of Cambridge, United Kingdom (W.T., B.J.A., K.L.B., O.V.P., Y.N., K.J.B., S.G.F., T.A.G., P.F.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.). Centre for Trophoblast Research, University of Cambridge, United Kingdom (W.T., Y.N., K.J.B., T.A.G., P.G.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.). (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1525-1535, July 1, 2022. Background:Preeclampsia continues to be a prevalent pregnancy complication and underlying mechanisms remain controversial. A common feature of preeclampsia is utero-placenta hypoxia. In contrast to the impact of hypoxia on the (...) (Hypertension)
• 06:00
  Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic Peptide - Takeshi Tokudome Kentaro Otani Yuanjie Mao Lars Jørn Jensen Yuji Arai Takahiro Miyazaki Takashi Sonobe James T. Pearson Tsukasa Osaki Naoto Minamino Junji Ishida Akiyoshi Fukamizu Hayato Kawakami Daisuke Onozuka Kunihiro Nishimura Mikiya Miyazato Hirohito Nishimura Department of Biochemistry (T.T., Y.M., N.M., M.M., H.N.), National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan. Department of Regenerative Medicine and Tissue Engineering (K.O.), National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan. Department of Research Promotion and Management (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1409-1422, July 1, 2022. Background:ANP (atrial natriuretic peptide), acting through NPR1 (natriuretic peptide receptor 1), provokes hypotension. Such hypotension is thought to be due to ANP inducing vasodilation via NPR1 in the vasculature; however, the (...) (Hypertension)

5 May

Hypertension https://www.ahajournals.org/

• 11:00
  Epithelial Sodium Channel ? Subunit Is Expressed in Human Arteries and Has Potential Association With Hypertension - Puja Paudel Isabelle van Hout Richard W. Bunton Dominic J. Parry Sean Coffey Fiona J. McDonald Martin Fronius Department of Physiology, School of Biomedical Sciences (P.P., I.v.H., F.J.M., M.F.), University of Otago, Dunedin, New Zealand. HeartOtago (P.P., I.v.H., S.C., M.F.), University of Otago, Dunedin, New Zealand. Department of Medicine, Otago Medical School (S.C.), University of Otago, Dunedin, New Zealand. Department of Cardiothoracic Surgery, Otago Medical School, Dunedin Hospital, New Zealand (R.W.B., (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1385-1394, July 1, 2022. Background:Elevated expression and increased activity of vascular epithelial sodium channel (ENaC) can result in vascular dysfunction in small animal models. However, there is limited or no knowledge on expression and function of (...) (Hypertension)
• 11:00
  Midgestation Leptin Infusion Induces Characteristics of Clinical Preeclampsia in Mice, Which Is Ablated by Endothelial Mineralocorticoid Receptor Deletion - Jessica L. Faulkner Derrian Wright Galina Antonova Iris Z. Jaffe Simone Kennard Eric J. Belin de Chantemèle Department of Physiology (J.L.F.), Medical College of Georgia at Augusta University. Vascular Biology Center (D.W., G.A., S.K., E.J.B.d.C.), Medical College of Georgia at Augusta University. Department of Cardiology (E.J.B.d.C.), Medical College of Georgia at Augusta University. Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1536-1547, July 1, 2022. Background:Patients with preeclampsia demonstrate increases in placental leptin production in midgestation, and an associated increase in late gestation plasma leptin levels. The consequences of mid-late gestation increases in (...) (Hypertension)

4 May

Hypertension https://www.ahajournals.org/

• 11:00
  Mineralocorticoid Receptor Antagonists Cause Natriuresis in the Absence of Aldosterone - Yujiro Maeoka Xiao-Tong Su Wen-Hui Wang Xin-Peng Duan Avika Sharma Na Li Olivier Staub James A. McCormick David H. Ellison Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland (Y.M., X.-T.S., A.S., J.A.M., D.H.E.). Department of Pharmacology, New York Medical College, Valhalla (W.-H.W., X.-P.D.). Department of Pharmacology and Toxicology, University of Lausanne, Switzerland (N.L., O.S.). LeDucq Transatlantic Network of Excellence (O.S., D.H.E.). Veterans Affairs Portland Healthcare System, Portland, OR (D.H.E.). Oregon Clinical (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1423-1434, July 1, 2022. Background:MR (mineralocorticoid receptor) antagonists are recommended for patients with resistant hypertension even when circulating aldosterone levels are not high. Although aldosterone activates MR to increase epithelial sodium (...) (Hypertension)
• 11:00
  Abnormal Cyclic Nucleotide Signaling at the Outer Mitochondrial Membrane In Sympathetic Neurons During the Early Stages of Hypertension - Dan Li Kun Liu Harvey Davis Calum Robertson Oliver C. Neely Adib Tarafdar Ni Li Konstantinos Lefkimmiatis Manuela Zaccolo David J. Paterson Burdon Sanderson Cardiac Science Centre and BHF Centre of Research Excellence, Department of Physiology, Anatomy and Genetics (D.L., K.L., H.D., C.R., O.C.N., A.T., N.L., M.Z., D.J.P.), University of Oxford, United Kingdom. Chinese Academy of Medical Sciences Oxford Institute (COI), Nuffield Department of Medicine Research Building (N.L.), University of Oxford, United Kingdom. Department of Neuroscience, Physiology and Pharmacology, University College (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1374-1384, July 1, 2022. Background:Disruption of cyclic nucleotide signaling in sympathetic postganglionic neurons contributes to impaired intracellular calcium handling (Ca2+) and the development of dysautonomia during the early stages of hypertension, (...) (Hypertension)

3 May

Hypertension https://www.ahajournals.org/

• 11:01
  Day to Day Blood Pressure Variability Associated With Cerebral Arterial Dilation and White Matter Hyperintensity - Boyu Zhang Yajing Huo Zidong Yang Huihui Lv Yilin Wang Jianfeng Feng Yan Han He Wang Institute of Science and Technology for Brain-Inspired Intelligence (B.Z., Z.Y., J.F., H.W.), Fudan University, Shanghai, China. Department of Neurology, Zhongshan Hospital (H.W.), Fudan University, Shanghai, China. Human Phenome Institute (H.W.), Fudan University, Shanghai, China. Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, China (B.Z., Z.Y., J.F., H.W.). Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1455-1465, July 1, 2022. Background:Previous studies suggested blood pressure variability (BPV) might help reveal interactions between blood pressure fluctuation and white matter lesions, and the impact of elevated BPV on white matter hyperintensity (WMH) (...) (Hypertension)
• 11:00
  Role of Antihypertensive Treatment and Blood Pressure Control in the Occurrence of Adverse Pregnancy Outcomes: a Population-Based Study of Linked Electronic Health Records - Sukainah Al Khalaf Ali S. Khashan Lucy C. Chappell Éilis J. O’Reilly Fergus P. McCarthy School of Public Health (S.A.K., A.S.K., E.J.O.), University College Cork, Ireland. INFANT Research Centre (S.A.K., A.S.K., F.P.M.), University College Cork, Ireland. Department of Women and Children’s Health, King’s College London (L.C.C.). Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA (E.J.O.). Environmental Research Institute, University College Cork, Ireland (E.J.O.). Environmental Research Institute, University College Cork, Ireland (E.J.O.). Department of Obstetrics (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1548-1558, July 1, 2022. Background:Chronic hypertension (CH) adversely impacts pregnancy. It remains unclear whether antihypertensive treatment alters these risks. We examined the role of antihypertensive treatment in the association between CH and (...) (Hypertension)
• 11:00
  Association Between Hypertension and Incident Infective Endocarditis - Gyu Bae Lee Koh Eun Shin Kyungdo Han Ho-Sung Son Jae-Seung Jung Yang-Hyun Kim Hee-Jung Kim Department of Family Medicine, Korea University Anam Hospital, Korea University, Seoul (G.B.L., K.E.S., Y.-H.K.). Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea (K.H.). Department of Thoracic and Cardiovascular Surgery, Korea University Anam Hospital, Korea University (H.-S.S., J.-S.J., H.-J.K.). Hypertension
  Hypertension, Volume 79, Issue 7, Page 1466-1474, July 1, 2022. Background:This study aimed to evaluate the association of hypertension with incident infective endocarditis (IE) by investigating the incidence of IE according to blood pressure levels using the National Health Insurance Service (...) (Hypertension)

28 April

Hypertension https://www.ahajournals.org/

• 11:00
  Calcium Sensing Receptor Variants Increase Pulmonary Hypertension Susceptibility - Bingxun Liu Yun-Peng Wei Xiaohang Fan Xiaoyi Hu Zeshuai Chen Xiaoyuan Liu Yan Xu Lu Wang Tao Wang Matthieu Ruiz Jocelyn Dupuis Ping Yuan Jinming Liu Songling Huang Liping Zhu Zhi-Cheng Jing Qinghua Hu Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China (B.L., X.F., Z.C., X.L.,Y.X., L.Z., Q.H.). Key Laboratory of Pulmonary Diseases of Ministry of Health, Tongji Medical College, HUST, Wuhan, China (B.X., X.F., X.H., Z.C., X.L., Y.X., L.W., T.W., L.Z., Q.H.). Department of Cardiology, State Key (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1348-1360, July 1, 2022. Background:Pulmonary arterial hypertension is an incurable disease, in which the extracellular CaSR (calcium sensing receptor) is mechanistically important. This study was aimed to genetically link theCaSRgene and function to the (...) (Hypertension)
• 11:00
  DPP4 Promotes Human Endothelial Cell Senescence and Dysfunction via the PAR2–COX-2–TP Axis and NLRP3 Inflammasome Activation - Inés Valencia Susana Vallejo Pilar Dongil Alejandra Romero Álvaro San Hipólito-Luengo Licia Shamoon María Posada Damián García-Olmo Raffaelle Carraro Jorge D. Erusalimsky Tania Romacho Concepción Peiró Carlos F. Sánchez-Ferrer Department of Pharmacology and Therapeutics, School of Medicine (I.V., S.V., P.D., A.R., Á.S.H.-L., L.S., T.R., C.P., C.F.S.-F.), Universidad Autónoma de Madrid, Spain. PhD Programme in Pharmacology and Physiology, Doctoral School (I.V., L.S.), Universidad Autónoma de Madrid, Spain. Department of Medicine, School of Medicine (R.C.), Universidad Autónoma de Madrid, Spain. (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1361-1373, July 1, 2022. Background:Abnormal accumulation of senescent cells in the vessel wall leads to a compromised vascular function contributing to vascular aging. Soluble DPP4 (dipeptidyl peptidase 4; sDPP4) secretion from visceral adipose tissue is (...) (Hypertension)

26 April

Hypertension https://www.ahajournals.org/

• 11:00
  Lipidomic Signatures of Dairy Consumption and Associated Changes in Blood Pressure and Other Cardiovascular Risk Factors Among Chinese Adults - Huan Yun Liang Sun Qingqing Wu Yaogan Luo Qibin Qi Huaixing Li Weiqiong Gu Jiqiu Wang Guang Ning Rong Zeng Geng Zong Xu Lin Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. (H.Y., L.S., Y.L., H.L., G.Z., X.L.) Key Laboratory of Systems Biology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. (R.Z., X.L.) Key Laboratory of Systems Health Science of Zhejiang Province, Hangzhou Institute for Advanced Study, University of Chinese (...) Hypertension
  Hypertension, Ahead of Print. Background:Omics data may provide a unique opportunity to discover dairy-related biomarkers and their linked cardiovascular health.Methods:Dairy-related lipidomic signatures were discovered in baseline data from a Chinese cohort study (n=2140) and replicated in (...) (Hypertension)

25 April

Hypertension https://www.ahajournals.org/

• 11:01
  Jeremiah Stamler, MD (1919–2022) - Philip Greenland Linda V. Van Horn Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL. Hypertension
  Hypertension, Volume 79, Issue 7, Page e111-e112, July 1, 2022. (Hypertension)
• 11:00
  Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: a Review of Shared Cardiometabolic Risk Factors - Emir Muzurovi? Carol Chiung-Hui Peng Matthew J. Belanger Despina Sanoudou Dimitri P. Mikhailidis Christos S. Mantzoros Department of Internal Medicine, Endocrinology Section, Clinical Centre of Montenegro, Podgorica (E.M.). Faculty of Medicine, University of Montenegro, Podgorica, Montenegro (E.M.). Section of Endocrinology, Diabetes, Nutrition & Weight Management, Boston University School of Medicine, Boston, MA (C.C.-H.P.). Northeast Medical Group, Yale New Haven Health, New Haven, CT (M.J.B.). Clinical Genomics and Pharmacogenomics Unit, 4th Department of Internal Medicine, Attikon (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1319-1326, July 1, 2022. The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising. NAFLD/nonalcoholic steatohepatitis (NASH) is associated not only with hepatic morbidity and mortality but also with an increased cardiovascular risk. NAFLD and (...) (Hypertension)

19 April

Hypertension https://www.ahajournals.org/

• 11:00
  Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal Pulmonary Hypertension in High-Altitude Populations - Alexandra Heath-Freudenthal Lilian Toledo-Jaldin Inge von Alvensleben Litzi Lazo-Vega Rodrigo Mizutani Margaret Stalker Hussna Yasini Fanny Mendizabal Jesus Dorado Madera William Mundo Melany Castro-Monrroy Julie A. Houck Any Moreno-Aramayo Valquiria Miranda-Garrido Emily J. Su Dino A. Giussani Steven H. Abman Lorna G. Moore Colleen G. Julian Kardiozentrum, La Paz, Bolivia (A.H.-F., I.v.A., F.M.). Hospital Materno-Infantil, La Paz, Bolivia (L.T.J., L.L.V., R.M., A.M.-A., V.M.-G.). University of Colorado School of Medicine, Aurora, Colorado (M.S., W.M.). College of Liberal Arts and (...) Hypertension
  Hypertension, Volume 79, Issue 6, Page 1286-1296, June 1, 2022. Background:Preeclampsia and fetal growth restriction increase cardiopulmonary disease risk for affected offspring and occur more frequently at high-altitude (?2500 m). Retrospective studies indicate that birth to a preeclampsia (...) (Hypertension)

18 April

Hypertension https://www.ahajournals.org/

• 11:00
  Type 1 Angiotensin Receptors on CD11c-Expressing Cells Protect Against Hypertension by Regulating Dendritic Cell–Mediated T Cell Activation - Xiaohan Lu Jiandong Zhang Yi Wen Jiafa Ren Robert Griffiths Nathan P. Rudemiller Shintaro Ide Tomokazu Souma Steven D. Crowley Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, NC (X.L., Y.W., J.R., R.G., N.P.R., S.I., T.S., S,D.C.). Division of Cardiology, Department of Medicine, University of North Carolina at Chapel Hill (J.Z.). Hypertension
  Hypertension, Volume 79, Issue 6, Page 1227-1236, June 1, 2022. Background:Type 1 angiotensin (AT1) receptors are expressed on immune cells, and we previously found that bone marrow–derived AT1receptors protect against Ang (angiotensin) II-induced hypertension. CD11c is expressed on myeloid (...) (Hypertension)

13 April

Hypertension https://www.ahajournals.org/

• 08:00
  PKG, CXL, and HNO. Relax! - Katrin Schröder Institute of Cardiovascular Physiology, Vascular Research Center, Faculty of Medicine, Goethe-University, Germany. Hypertension
  Hypertension, Volume 79, Issue 5, Page 957-959, May 1, 2022. (Hypertension)

6 April

Hypertension https://www.ahajournals.org/

• 11:00
  Aortic Body Chemoreceptors Regulate Coronary Blood Flow in Conscious Control and Hypertensive Sheep - Dylan Pen Julia Shanks Carolyn Barrett Yonis Abukar Julian F.R. Paton Rohit Ramchandra Manaaki Manawa – The Centre for Heart Research and the Department of Physiology, University of Auckland, New Zealand. Hypertension
  Hypertension, Volume 79, Issue 6, Page 1275-1285, June 1, 2022. Background:Peripheral arterial chemoreceptors monitor the chemical composition of arterial blood and include both the carotid and aortic bodies (ABs). While the role of the carotid bodies has been extensively studied, the (...) (Hypertension)

5 April

Hypertension https://www.ahajournals.org/

• 11:00
  Improved Diagnostic Accuracy of Clonidine Suppression Testing Using an Age-Related Cutoff for Plasma Normetanephrine - Hanna Remde Christina Pamporaki Marcus Quinkler Svenja Nölting Aleksander Prejbisz Henri J.L.M. Timmers Jimmy Masjkur Carmina T. Fuss Martin Fassnacht Graeme Eisenhofer Timo Deutschbein Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, Germany (H.R., C.T.F., M.F., T.D.). Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany (C.P., J.M., G.E.). Endocrinology in Charlottenburg, Berlin, Germany (M.Q.). Department of Endocrinology, Diabetology and Clinical Nutrition, (...) Hypertension
  Hypertension, Volume 79, Issue 6, Page 1257-1264, June 1, 2022. Background:Moderately elevated plasma normetanephrine (NMN) levels are frequent among patients with suspected pheochromocytoma and paraganglioma (PPGL). Clonidine suppression testing (CST) is recommended to distinguish patients (...) (Hypertension)
• 11:00
  Individualized Beta-Blocker Treatment for High Blood Pressure Dictated by Medical Comorbidities: Indications Beyond the 2018 European Society of Cardiology/European Society of Hypertension Guidelines - Giuseppe Mancia Sverre E. Kjeldsen Reinhold Kreutz Atul Pathak Guido Grassi Murray Esler University of Milano-Bicocca, Milan, Italy (G.M., G.G.). Department of Cardiology, University of Oslo, Ullevaal Hospital, Norway (S.E.K.). Charité – Universitätsmedizin Berlin, Institute of Clinical Pharmacology and Toxicology, Germany (R.K.). Department of Cardiology, Centre Hospitalier Princesse Grace, Monte Carlo, Monaco (A.P.). Human Neurotransmitters Laboratory, Baker Heart and Diabetes Institute, and Monash University, Melbourne, Australia (...) Hypertension
  Hypertension, Volume 79, Issue 6, Page 1153-1166, June 1, 2022. Several hypertension guidelines have removed beta-blockers from their previous position as first-choice drugs for the treatment of hypertension. However, this downgrading may not be justified by available evidence because (...) (Hypertension)

4 April

Hypertension https://www.ahajournals.org/

• 11:00
  Association of Polygenic Risk Score With Blood Pressure and Adverse Cardiovascular Outcomes in Individuals With Type II Diabetes: Insights From the ACCORD Trial - Vibhu Parcha Akhil Pampana Adam P. Bress Marguerite R. Irvin Garima Arora Pankaj Arora Division of Cardiovascular Disease (V.P., A.P., G.A., P.A.) Department of Epidemiology, School of Public Health (M.R.I.), University of Alabama at Birmingham. Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City (A.B.). Section of Cardiology, Birmingham Veterans Affairs Medical Center, AL (P.A.). Hypertension
  Hypertension, Volume 79, Issue 5, Page e100-e102, May 1, 2022. (Hypertension)

1 April

Hypertension https://www.ahajournals.org/

• 11:00
  Associations of Long-Term Visit-to-Visit Blood Pressure Variability With Subclinical Kidney Damage and Albuminuria in Adulthood: a 30-Year Prospective Cohort Study - Yang Wang Peng Zhao Chao Chu Ming-Fei Du Xiao-Yu Zhang Ting Zou Gui-Lin Hu Hao-Wei Zhou Hao Jia Yue-Yuan Liao Chen Chen Qiong Ma Dan Wang Yu Yan Yue Sun Ke-Ke Wang Ze-Jiaxin Niu Xi Zhang Zi-Yue Man Yong-Xing Wu Lan Wang Hui-Xian Li Jie Zhang Chun-Hua Li Wei-Hua Gao Ke Gao Wan-Hong Lu Gary V. Desir Christian Delles Fang-Yao Chen Jian-Jun Mu Department of Cardiovascular Medicine (Y.W., C. Chu, M.-F.D., T.Z., G.-L.H., H.-W.Z., H.J., Y.-Y.L., C. Chen, Q.M., D.W., Y.Y., Y.S., K.-K.W., Z.-J.N., X.Z., Z.-Y.M., K.G., J.-J.M.), Department of Critical Care Medicine (Y.-X.W.), First Affiliated (...) Hypertension
  Hypertension, Volume 79, Issue 6, Page 1247-1256, June 1, 2022. Background:Recent evidence indicates that long-term visit-to-visit blood pressure variability (BPV) may be associated with risk of cardiovascular disease. We, therefore, aimed to determine the potential associations of long-term (...) (Hypertension)

31 March

Hypertension https://www.ahajournals.org/

• 11:00
  DP1 (Prostaglandin D2 Receptor 1) Activation Protects Against Vascular Remodeling and Vascular Smooth Muscle Cell Transition to Myofibroblasts in Angiotensin II–Induced Hypertension in Mice - Fangdi Zou Yong Li Shijie Zhang Jian Zhang Department of Pharmacology, School of Basic Medical Sciences (F.Z., Y.L., S.Z., J.Z.), Tianjin Medical University, China. School of Pharmacy (F.Z.), Tianjin Medical University, China. School of Pharmacy, East China University of Science and Technology, Shanghai, China (J.Z.). Hypertension
  Hypertension, Volume 79, Issue 6, Page 1203-1215, June 1, 2022. Background:Vascular smooth muscle cell (VSMC) phenotype transition plays an essential role in vascular remodeling. PGD2(Prostaglandin D2) is involved in cardiovascular inflammation. In this study, we aimed to investigates the role (...) (Hypertension)
• 11:00
  Loss of Endothelial Cytochrome P450 Reductase Induces Vascular Dysfunction in Mice - Pedro Felipe Malacarne Corina Ratiu Anna Gajos-Draus Niklas Müller Melina Lopez Beatrice Pflüger-Müller Xinxin Ding Timothy Warwick James Oo Mauro Siragusa Carlo Angioni Stefan Günther Andreas Weigert Gerd Geißlinger Dieter Lütjohann Wolf-Hagen Schunck Ingrid Fleming Ralf P. Brandes Flávia Rezende Institute for Cardiovascular Physiology (P.F.M., C.R., A.G.-D., N.M., M.L., B.P.-M., T.W., J.O., R.P.B., F.R.), Goethe-University, Frankfurt, Germany. Institute for Vascular Signalling (M.S., I.F.), Goethe-University, Frankfurt, Germany. Institute for Clinical Pharmacology (C.A., G.G.), (...) Hypertension
  Hypertension, Volume 79, Issue 6, Page 1216-1226, June 1, 2022. Background:POR (cytochrome P450 reductase) provides electrons for the catalytic activity of the CYP (cytochrome P450) monooxygenases. CYPs are dual-function enzymes as they generate protective vasoactive mediators derived from (...) (Hypertension)

29 March

Hypertension https://www.ahajournals.org/

• 11:00
  Insights From Matched Office and Ambulatory Blood Pressure in Youth: Clinical Relevance - Empar Lurbe Josep Redon Julio Alvarez Maria Grau-Pérez Fernando Martinez Giuseppe Mancia Pediatric Department, Consorcio Hospital General (E.L., J.A.), University of Valencia, Spain. Cardiovascular and Renal Research Group, INCLIVA Research Institute (J.R., M.G.-P., F.M.), University of Valencia, Spain. Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain (E.L., J.R., J.A.). Internal Medicine Hospital Clínico of Valencia, Spain (F.M.). University of Milano-Bicocca, Italy (...) Hypertension
  Hypertension, Volume 79, Issue 6, Page 1237-1246, June 1, 2022. Background:Information on the relationship between ambulatory blood pressure (ABP) and concurrently office blood pressure (BP) values in youth still suffers from limitations. We provide information on the differences between office (...) (Hypertension)

28 March

Hypertension https://www.ahajournals.org/

• 11:00
  Omeprazole Administration in Preterm Preeclampsia: a Randomized Controlled Trial to Study Its Effect on sFlt-1 (Soluble Fms-Like Tyrosine Kinase-1), PlGF (Placental Growth Factor), and ET-1 (Endothelin-1) - Rugina I. Neuman Milan D. Baars Langeza Saleh Michelle Broekhuizen Daan Nieboer Jérôme Cornette Sam Schoenmakers Michel Verhoeven Birgit C.P. Koch Henk Russcher Sjoerd A.A. van den Berg Anton H. van den Meiracker Willy Visser A.H. Jan Danser Department of Internal Medicine, Division of Pharmacology and Vascular Medicine (R.I.N., L.S., M.B., A.H.v.d.M., W.V., A.H.J.D.), Erasmus MC University Medical Center, Rotterdam, The Netherlands. Department of Obstetrics and Gynecology, Division of Obstetrics and Fetal Medicine (R.I.N., M.D.B., L.S., J.C., S.S., W.V.), Erasmus MC University Medical (...) Hypertension
  Hypertension, Volume 79, Issue 6, Page 1297-1307, June 1, 2022. Background:Low sFlt-1 (soluble Fms-like tyrosine kinase-1) and ET-1 (endothelin-1) levels have been reported in preeclamptic women using proton pump inhibitors.Methods:Here, we examined whether the proton pump inhibitor omeprazole (...) (Hypertension)

23 March

Hypertension https://www.ahajournals.org/

• 10:00
  Ten-Second Heart Rate Variability, Its Changes Over Time, and the Development of Hypertension - Jeonggyu Kang Yoosoo Chang Yejin Kim Hocheol Shin Seungho Ryu Total Healthcare Center (J.K.), Sungkyunkwan University, Seoul, South Korea. Center for Cohort Studies, Total Healthcare Center (J.K., Y.C., Y.K., H.S., S.R.), Sungkyunkwan University, Seoul, South Korea. Department of Occupational and Environmental Medicine (Y.C., S.R.), Sungkyunkwan University, Seoul, South Korea. Department of Family Medicine (H.S.), Sungkyunkwan University, Seoul, South Korea. Kangbuk Samsung Hospital, School of Medicine and Department of Clinical Research Design and Evaluation, SAIHST (Y.C., S.R.), (...) Hypertension
  Hypertension, Volume 79, Issue 6, Page 1308-1318, June 1, 2022. Background:The role of ultrashort-term heart rate variability (HRV) and its temporal changes in incident hypertension are unknown. We aimed to investigate the association between 10-second HRV, its changes, and incident (...) (Hypertension)

18 March

Hypertension https://www.ahajournals.org/

• 10:00
  A Rare Disease Leading to Hypertension - Jing Chen Xin Chen Anna F. Dominiczak Robert M. Carey Cheryl L. Laffer Fernando Elijovich Sandra J. Taler Tanja Dudenbostel Rhian M. Touyz Ji-Guang Wang Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China (J.C., X.C.). BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland, United Kingdom (A.F.D.). Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville (R.M.C.). Division of Clinical Pharmacology, (...) Hypertension
  Hypertension, Volume 79, Issue 6, Page 1147-1152, June 1, 2022. (Hypertension)

17 March

Hypertension https://www.ahajournals.org/

• 09:16
  A Message to the Hypertension Community Regarding the Ukraine Crisis - Rhian M. Touyz David G. Harrison Research Institute of the McGill University Health Centre, Department of Medicine, McGill University, Montreal, Canada (R.M.T.). Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (D.G.H.). Hypertension
  Hypertension, Volume 79, Issue 6, Page 1145-1146, June 1, 2022. (Hypertension)
• 10:00
  Na+-Retaining Action of COX-2 (Cyclooxygenase-2)/EP1 Pathway in the Collecting Duct via Activation of Intrarenal Renin-Angiotensin-Aldosterone System and Epithelial Sodium Channel - Chuanming Xu Guangrui Yang Ziwei Fu Yanting Chen Shiying Xie Fei Wang Tianxin Yang Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City. Hypertension
  Hypertension, Volume 79, Issue 6, Page 1190-1202, June 1, 2022. Background:The collecting duct (CD) is a major site of both biosynthesis and action of prostaglandin E2as highlighted by the predominant expression of COX-2 (cyclooxygenase-2) and some E-prostanoid (EP) subtypes at this nephron (...) (Hypertension)
• 10:00
  Blood Pressure Hyperreactivity to Standing: a Predictor of Adverse Outcome in Young Hypertensive Patients - Paolo Palatini Lucio Mos Francesca Saladini Marcello Rattazzi Department of Medicine, University of Padova, Italy (P.P., F.S., M.R.). San Antonio Hospital, San Daniele del Friuli, Italy (L.M.). Hypertension
  Hypertension, Volume 79, Issue 5, Page 984-992, May 1, 2022. The prognostic significance and the mechanisms of blood pressure (BP) hyperreactivity to standing remain controversial. This study aims to evaluate the association of orthostatic hyperreactivity with major adverse cardiovascular and (...) (Hypertension)

16 March

Hypertension https://www.ahajournals.org/

• 10:01
  Cerebrovascular Variants and the Role of the Selfish Brain in Young-Onset Hypertension - Nathan E. Manghat Elizabeth Robinson Konstantina Mitrousi Jonathan C.L. Rodrigues Thomas Hinton Julian F.R. Paton Richard G. Wise Angus K. Nightingale Emma C. Hart Department of Radiology, Bristol Royal Infirmary, University Hospitals Bristol and Weston NHS Foundation Trust, United Kingdom (N.E.M., E.R., K.M.). Cardionomics Research Group, School of Physiology, Pharmacology and Neurosciences, University of Bristol, United Kingdom (N.E.M., K.M., T.H., A.K.N., E.C.H.). Department of Radiology, Royal United Hospitals Bath NHS Foundation Trust (J.C.L.R.). Department of Health, University of (...) Hypertension
  Hypertension, Volume 79, Issue 6, Page 1265-1274, June 1, 2022. Background:Variants in the posterior anatomy of the cerebral circulation are associated with hypertension and lower cerebral blood flow in midlife (age ?55 years); however, whether these variants are a result of aging or long-term (...) (Hypertension)
• 10:01
  Acute Increase of Renal Perfusion Pressure Causes Rapid Activation of mTORC1 (Mechanistic Target Of Rapamycin Complex 1) and Leukocyte Infiltration - Satoshi Shimada Chun Yang Vikash Kumar David L. Mattson Allen W. Cowley Department of Physiology, Medical College of Wisconsin, Milwaukee (S.S., C.Y., V.K., D.L.M., A.W.C.). Now with: Department of Physiology, Medical College of Georgia at Augusta University (D.L.M.). Hypertension
  Hypertension, Volume 79, Issue 6, Page 1180-1189, June 1, 2022. Background:The present study in Sprague-Dawley rats determined the effects of a rapid rise of renal perfusion pressure (RPP) upon the activation of mTOR (mechanistic target of rapamycin), and the effects upon the infiltration of (...) (Hypertension)
• 10:00
  Utilizing Mobile Health Units for Mass Hypertension Screening in Socially Vulnerable Communities Across Detroit - Robert D. Brook Katee Dawood Bethany Foster Randi M. Foust Catherine Gaughan Paul Kurian Brian Reed Andrea L. Jones Barbara Vernon Phillip D. Levy Division of Cardiovascular Diseases (R.D.B.), Wayne State University. Integrative Biosciences Center (R.D.B., K.D., B.F., B.R., A.L.J., P.D.L.), Wayne State University. Wayne Health (R.D.B., R.M.F., C.G., P.K., B.V., P.D.L.), Wayne State University. Department of Emergency Medicine (B.F., A.L.J., P.D.L.), Wayne State (...) Hypertension
  Hypertension, Volume 79, Issue 6, Page e106-e108, June 1, 2022. (Hypertension)
• 10:00
  Is the Pannexin-1 Channel a Mechanism Underlying Hypertension in Humans? a Translational Study of Human Hypertension - Lasse Gliemann Andrea Tamariz-Ellemann Camilla Collin Hansen Thomas Svare Ehlers Sophie Møller Ylva Hellsten Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark. Hypertension
  Hypertension, Volume 79, Issue 5, Page 1132-1143, May 1, 2022. Background:In preclinical models, the pannexin-1 channel has been shown to be involved in blood pressure regulation through an effect on peripheral vascular resistance. Pannexin-1 releases ATP, which can activate constrictive (...) (Hypertension)

11 March

Hypertension https://www.ahajournals.org/

• 11:00
  Emerging Viral Infections, Hypertension, and Cardiovascular Disease in Sub-Saharan Africa: A Narrative Review - Lily D. Yan Sarah S. Matuja Kevin J. Pain Margaret L. McNairy Anthony O. Etyang Robert N. Peck Center for Global Health and Division of General Internal Medicine (L.D.Y., M.L.M., R.N.P.), Weill Cornell Medicine, New York, NY. Samuel J. Wood Library and C.V. Starr Biomedical Information Center (K.J.P.), Weill Cornell Medicine, New York, NY. Department of Medicine, Weill Bugando School of Medicine, Mwanza, Tanzania (S.S.M., R.N.P.). KEMRI-Wellcome Trust Research Program, Kilifi, Kenya (A.O.E.). Mwanza Interventions Trial Unit, Mwanza, Tanzania (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 898-905, May 1, 2022. Background:Sub-Saharan Africa (SSA) has the highest age-adjusted burden of hypertension and cardiovascular disease (CVD). SSA also experiences many viral infections due to unique environmental and societal factors. The purpose of this (...) (Hypertension)

10 March

Hypertension https://www.ahajournals.org/

• 11:00
  Inverse Association Between Variety of Proteins With Appropriate Quantity From Different Food Sources and New-Onset Hypertension - Chun Zhou Qimeng Wu Ziliang Ye Mengyi Liu Zhuxian Zhang Yuanyuan Zhang Huan Li Panpan He Qinqin Li Chengzhang Liu Xianhui Qin National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Division of Nephrology, Nanfang Hospital, Southern Medical University, China (C.Z., Q.W., Z.Y., M.L., Z.Z., Y.Z., H.L., P.H., Q.L., C.L., X.Q.). Department of Epidemiology and Biostatistics, School of Public Health (Q.L., C.L., X.Q.), (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 1017-1027, May 1, 2022. The relationships of the variety and quantity of different sources of dietary proteins with hypertension remain uncertain. We aimed to investigate associations between the variety and quantity of proteins intake from 8 major food (...) (Hypertension)
• 11:00
  Cost-Effectiveness of Antihypertensive Deprescribing in Primary Care: a Markov Modelling Study Using Data From the OPTiMISE Trial - Sue Jowett Shahela Kodabuckus Gary A. Ford F.D. Richard Hobbs Mark Lown Jonathan Mant Rupert Payne Richard J. McManus James P. Sheppard Institute of Applied Health Research, University of Birmingham, United Kingdom (S.J., S.K.). Oxford University Hospitals NHS Foundation Trust and University of Oxford, United Kingdom (G.A.F.). Nuffield Department of Primary Care Health Sciences, University of Oxford, United Kingdom (F.D.R.H., R.J.M., J.P.S.). Primary Care Research Centre, University of Southampton, Southampton, United Kingdom (M.L.). Primary Care Unit, Department of Public Health & (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 1122-1131, May 1, 2022. Background:Deprescribing of antihypertensive medications for older patients with normal blood pressure is recommended by some clinical guidelines, where the potential harms of treatment may outweigh the benefits. This study aimed to (...) (Hypertension)
• 11:00
  Diagnosis and Monitoring of White Coat Hypertension in Pregnancy: an ISSHP Consensus Delphi Procedure - Sonia Johnson Sanne Gordijn Stefanie Damhuis Wessel Ganzevoort Mark Brown Peter von Dadelszen Laura A. Magee Asma Khalil Barts and the London Medical School, Queen Mary University of London, United Kingdom (S.J.). Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, the Netherlands (S.G., S.D.). Department of Obstetrics and Gynaecology, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands (W.G.). Department of Renal Medicine, St. George Hospital and University of New South Wales, Sydney, Australia (M.B.). (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 993-1005, May 1, 2022. Background:There is no accepted definition or standardized monitoring for white coat hypertension in pregnancy. This Delphi procedure aimed to reach consensus on out-of-office blood pressure (BP) monitoring, and white coat (...) (Hypertension)

9 March

Hypertension https://www.ahajournals.org/

• 11:00
  Impact of Antihypertensive Drug Class on Outcomes in SPRINT - Douglas D. DeCarolis Amy Gravely Christine M. Olney Areef Ishani Minneapolis VA Health Care System, MN (D.D.D.). Research Service, Minneapolis VA Health Care System, MN (A.G., C.M.O.). University of Minnesota, School of Nursing and University of Minnesota, Rehabilitation Medicine, Minneapolis, MN (C.M.O.). Minneapolis VA Health Care System and University of Minnesota‚ MN (A.I.). Hypertension
  Hypertension, Volume 79, Issue 5, Page 1112-1121, May 1, 2022. Background:The primary objective of this analysis is to assess if greater exposure to any major antihypertensive drug class was associated with reduced primary composite outcome events in SPRINT (Systolic Blood Pressure Intervention (...) (Hypertension)
• 08:00
  White-Coat Free Genome-Wide Epigenetics of Human Blood Pressure - Daniel Vaiman Institut Cochin, U1016 INSERM-UMR8104 CNRS, Université de Paris, France. Hypertension
  Hypertension, Volume 79, Issue 4, Page 773-774, April 1, 2022. (Hypertension)
• 08:00
  Aldosterone and Aortic Aneurysms: the Dissection of a Potential New Mechanism to Prevent Rupture - Suman Srinivasa Yan E. Yuan Gail K. Adler Metabolism Unit, Massachusetts General Hospital (S.S.), Harvard Medical School, Boston, MA. Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital (Y.E.Y., G.K.A.), Harvard Medical School, Boston, MA. Hypertension
  Hypertension, Volume 79, Issue 4, Page 747-749, April 1, 2022. (Hypertension)
• 08:00
  Another Nail in the Coffin of Causality for the Diastolic Blood Pressure J Curve - John P. Birrane Matteo Foschi Simona Sacco John W. McEvoy National Institute for Prevention and Cardiovascular Health, National University of Ireland Galway School of Medicine, Galway, Ireland (J.P.B., J.W.M.). Department of Neuroscience, Neurology Unit, S. Maria delle Croci Hospital of Ravenna, AUSL Romagna, Italy (M.F.). Department of Medical and Surgical Sciences, University of Bologna, Italy (M.F.). Neuroscience Section, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy (S.S.). Division of Cardiology, Department of Medicine, Ciccarone Center (...) Hypertension
  Hypertension, Volume 79, Issue 4, Page 794-797, April 1, 2022. (Hypertension)
• 08:00
  Will Food and Drug Administration Guidance to Reduce the Salt Content of Processed Foods Reduce Salt Intake and Save Lives? - Theodore W. Kurtz Michal Pravenec Stephen E. DiCarlo Department of Laboratory Medicine, University of California, San Francisco (T.W.K.). Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic (M.P.). Department of Physiology, College of Osteopathic Medicine, Michigan State University, East Lansing (S.E.D.). Hypertension
  Hypertension, Volume 79, Issue 4, Page 809-812, April 1, 2022. (Hypertension)

8 March

Hypertension https://www.ahajournals.org/

• 11:00
  Carotid Intima-Media Thickness Percentiles in Adolescence and Young Adulthood and Their Association With Obesity and Hypertensive Blood Pressure in a Population Cohort - Hannelore K. Neuhauser Julia Büschges Angelika Schaffrath Rosario Anja Schienkiewitz Giselle Sarganas Karsten Königstein Dieter Schweizer Arno Schmidt-Trucksäss Robert Koch Institute, Department of Epidemiology and Health Monitoring, Berlin, Germany (H.K.N., J.B., A.S.R., A.S., G.S.). DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany (H.K.N., J.B., A.S., G.S., K.K.). Department of Sport, Exercise and Health, Division Sports and Exercise Medicine, University of Basel, Switzerland (K.K., A.S.-T.). Fukuda Denshi Switzerland AG, Basel, Switzerland (...) Hypertension
  Hypertension, Volume 79, Issue 6, Page 1167-1176, June 1, 2022. Background:This study aimed to derive carotid intima media thickness (CIMT) percentiles from a population-based sample of adolescents and young adults using improved technology, standardization and quality control, and to (...) (Hypertension)

7 March

Hypertension https://www.ahajournals.org/

• 11:00
  Adolescent Blood Pressure and the Risk for Early Kidney Damage in Young Adulthood - Avishai M. Tsur Inbal Akavian Estela Derazne Dorit Tzur Asaf Vivante Ehud Grossman Ran S. Rotem Boris Fishman Arnon Afek Josef Coresh Gabriel Chodick Gilad Twig Israel Defense Forces, Medical Corps, Tel Hashomer, Ramat Gan, Israel (A.M.T., I.A., E.D., D.T., G.T.). Department of Military Medicine, Hebrew University of Jerusalem Faculty of Medicine, Jerusalem, Israel (A.M.T., I.A., G.T.). Department of Medicine (A.M.T., E.G., B.F.), Sheba Medical Center, Tel-Hashomer, Israel. Department of Pediatrics B and Pediatric Nephrology Unit, Edmond and Lily Safra Children’s Hospital (A.V.), Sheba (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 974-983, May 1, 2022. Background:Recent guidelines classified blood pressure above 130/80 mm Hg as hypertension. However, outcome data were lacking.Objective:To determine the association between blood pressure in adolescence and the risk for early kidney (...) (Hypertension)
• 11:00
  Upregulation of Endothelial DKK1 (Dickkopf 1) Promotes the Development of Pulmonary Hypertension Through the Sp1 (Specificity Protein 1)/SHMT2 (Serine Hydroxymethyltransferase 2) Pathway - Qianqian Wang Jingjing Tian Xuan Li Xiaolin Liu Tengfei Zheng Yachao Zhao Xiao Li Hongyu Zhong Dongdong Liu Wencheng Zhang Meng Zhang Mengmeng Li Mei Zhang The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 960-973, May 1, 2022. Background:Pulmonary hypertension (PH) is a cancer-like proliferative disease, which has no curative treatment options. The dysfunction of pulmonary artery endothelial cells plays a key role in PH. DKK1 (Dickkopf 1) is a secretory (...) (Hypertension)

4 March

Hypertension https://www.ahajournals.org/

• 11:00
  Risk Stratification by Cross-Classification of Central and Brachial Systolic Blood Pressure - Yi-Bang Cheng Lutgarde Thijs Lucas S. Aparicio Qi-Fang Huang Fang-Fei Wei Yu-Ling Yu Jessica Barochiner Chang-Sheng Sheng Wen-Yi Yang Teemu J. Niiranen José Boggia Zhen-Yu Zhang Katarzyna Stolarz-Skrzypek Natasza Gilis-Malinowska Valérie Tikhonoff Wiktoria Wojciechowska Edoardo Casiglia Krzysztof Narkiewicz Jan Filipovský Kalina Kawecka-Jaszcz Ji-Guang Wang Yan Li Jan A. Staessen Department of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 1101-1111, May 1, 2022. Background:Whether cardiovascular risk is more tightly associated with central (cSBP) than brachial (bSBP) systolic pressure remains debated, because of their close correlation and uncertain thresholds to differentiate cSBP into (...) (Hypertension)

2 March

Hypertension https://www.ahajournals.org/

• 11:02
  Capsaicin Attenuates Arterial Calcification Through Promoting SIRT6-Mediated Deacetylation and Degradation of Hif1? (Hypoxic-Inducible Factor-1 Alpha) - Dongling Luo Wenxin Li Changming Xie Li Yin Xiaoyan Su Jie Chen Hui Huang Department of Cardiology, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China (D.L., W.L., C.X., L.Y., H.H.). Department of Radiation Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China (J.C.). Department of Nephropathy, Tungwah Hospital of Sun Yat-sen University, Dongguan, China (X.S.). Hypertension
  Hypertension, Volume 79, Issue 5, Page 906-917, May 1, 2022. Background:Sustained Hif1? (hypoxic-inducible factor-1 alpha) accumulation plays a central role in osteogenic transdifferentiation and subsequent calcification. Capsaicin, the potent agonist of TRPV1 (transient receptor potential (...) (Hypertension)
• 11:00
  Platelet-Derived TGF (Transforming Growth Factor)-?1 Enhances the Aerobic Glycolysis of Pulmonary Arterial Smooth Muscle Cells by PKM2 (Pyruvate Kinase Muscle Isoform 2) Upregulation - Ying Zhu Dan Shu Xue Gong Meng Lu Qinyu Feng Xiang-Bin Zeng Han Zhang Jiahui Gao Ya-Wei Guo Luman Liu Rong Ma Liping Zhu Qinghua Hu Zhang-Yin Ming Department of Pharmacology, School of Basic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China (Y.Z., D.S., X.G., M.L., X.-B.Z., J.G., Y.W.G., L.L., R.M., Z.-Y.M.). The Key Laboratory for Drug Target Research and Pharmacodynamic Evaluation of Hubei Province, Wuhan, China (Y.Z., D.S., X.G., M.L., X.-B.Z., J.G., Y.W.G., L.L., R.M., Z.-Y.M.). Department of Pharmacy, School of Medicine, Wuhan University (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 932-945, May 1, 2022. Background:Metabolic reprogramming is a hallmark of pulmonary arterial hypertension. Platelet activation has been implicated in pulmonary arterial hypertension (PAH), whereas the role of platelet in the pathogenesis of PAH remains (...) (Hypertension)
• 11:00
  Myeloid Piezo1 Deletion Protects Renal Fibrosis by Restraining Macrophage Infiltration and Activation - Yu He Bo Deng Silin Liu Shangfei Luo Yile Ning Xianmei Pan Rentao Wan Yuan Chen Ziyan Zhang Jintao Jiang Honglin Xu Mingfeng Xia Jing Li Lingnan Medical Research Center (Y.H., B.D., S. Liu, S. Luo, Y.N., X.P., R.W., Y.C., Z.Z., J.J., H.X., J.L.) The First Affiliated Hospital (Y.H., B.D., S. Liu, S. Luo, Y.N., X.P., R.W., Y.C., Z.Z., J.J., H.X., J.L.), Guangzhou University of Chinese Medicine. Medical Research Center, Shandong University of Chinese Medicine, Jinan, China (M.X.). Faculty of Biological Sciences, University of Leeds, United Kingdom (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 918-931, May 1, 2022. Background:Macrophages play important roles in renal fibrosis, partially by sensing mechanical forces, including shear stress and increased stiffness. The mechanically activated cationic channel Piezo1 drives vascular formation and (...) (Hypertension)
• 11:00
  Microvascular ?-Adrenergic Receptor-Mediated Vasodilation Is Attenuated in Adults With Major Depressive Disorder - Jody L. Greaney Ashley M. Darling Jacqueline Mogle Erika F.H. Saunders Department of Kinesiology, The University of Texas at Arlington (J.L.G., A.M.D.). Edna Bennett Pierce Prevention Research Center, The Pennsylvania State University, University Park, PA (J.M.). Department of Psychiatry and Behavioral Health, Penn State College of Medicine, Hershey, PA (E.F.H.S.). Hypertension
  Hypertension, Volume 79, Issue 5, Page 1091-1100, May 1, 2022. Background:Major depressive disorder (MDD) is associated with sympathetic overactivity and alterations in peripheral adrenergic receptor function; however, no studies have directly assessed vasoconstrictor responsiveness in adults (...) (Hypertension)
• 11:00
  Worsening Postural Tachycardia Syndrome Is Associated With Increased Glucose-Dependent Insulinotropic Polypeptide Secretion - Nicholas C. Breier Sachin Y. Paranjape Shea Scudder Shahram E. Mehr Andre’ Diedrich Charles R. Flynn Luis E. Okamoto Bolette Hartmann Lærke Smidt Gasbjerg Cyndya A. Shibao Department of Medicine, Division of Clinical Pharmacology (N.C.B., S.Y.P., S.S., S.E.M., A.D., L.E.O., C.A.S.), Vanderbilt University Medical Center, Nashville, TN. Department of Surgery (C.R.F.), Vanderbilt University Medical Center, Nashville, TN. Department of Biomedical Science (B.H., L.S.G.), University of Copenhagen, Denmark. Novo Nordisk Foundation Center for Basic Metabolic Research (B.H.), University of (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page e89-e99, May 1, 2022. Background:Postural tachycardia syndrome (POTS) is characterized by excessive upright tachycardia and disabling presyncopal symptoms, which are exacerbated after consuming a high-carbohydrate meal; it is unknown, however, what is the (...) (Hypertension)

25 February

Hypertension https://www.ahajournals.org/

• 11:00
  Hypertensive Disorders of Pregnancy With and Without Prepregnancy Hypertension Are Associated With Incident Maternal Kidney Disease Subsequent to Delivery - Angela M. Malek Kelly J. Hunt Tanya N. Turan Julio Mateus Daniel T. Lackland Anika Lucas Dulaney A. Wilson Department of Public Health Sciences (A.M.M., K.J.H., D.A.W.), Medical University of South Carolina, Charleston. Department of Neurology (T.N.T., D.T.L.), Medical University of South Carolina, Charleston. Department of Obstetrics & Gynecology, Maternal-Fetal Medicine Division, Atrium Health, Charlotte, NC (J.M.). Department of Medicine, Division of Nephrology, Duke University, Durham, NC (...) Hypertension
  Hypertension, Volume 79, Issue 4, Page 844-854, April 1, 2022. Background:Maternal morbidity and mortality are related to prepregnancy hypertensive disease and hypertensive disorders of pregnancy (HDP) including preeclampsia (41.1% of HDP), eclampsia (1.3% of HDP), and gestational hypertension (...) (Hypertension)

23 February

Hypertension https://www.ahajournals.org/

• 11:00
  Effect of Antihypertensive Treatment on Cerebral Blood Flow in Older Adults: a Systematic Review and Meta-Analysis - Anniek E. van Rijssel Bram C. Stins Lucy C. Beishon Marit L. Sanders Terence J. Quinn Jurgen A.H.R. Claassen Rianne A.A. de Heus Radboud university medical center, Donders Institute for Brain Cognition and Behaviour, Department of Geriatric Medicine, Radboudumc Alzheimer Center, Nijmegen, the Netherlands (A.E.v.R., B.C.S., M.L.S., J.A.H.R.C., R.A.A.d.H.). Department of Cardiovascular Sciences, University of Leicester, United Kingdom (L.C.B.). Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 1067-1078, May 1, 2022. Background:In older age, the benefits of antihypertensive treatment (AHT) become less evident, with greater associated risk. Of particular concern is compromising cerebral blood flow (CBF), especially in those with cognitive (...) (Hypertension)
• 11:00
  Glucose Metabolic Disorders Enhance Vascular Dysfunction Triggered by Particulate Air Pollution: a Panel Study - Wu Chen Yiqun Han Yanwen Wang Xi Chen Xinghua Qiu Weiju Li Yifan Xu Tong Zhu BIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Center for Environment and Health (W.C., Y.H., Y.W., X.C., X.Q., Y.X., T.Z.), Peking University, Beijing, China. Peking University Hospital (W.L.), Peking University, Beijing, China. Environmental Research Group, MRC Centre for Environment and Health, Imperial College London, United Kingdom (Y.H.). National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China (Y.W.). Hebei Technology (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 1079-1090, May 1, 2022. Background:Vascular dysfunction is a biological pathway whereby particulate matter (PM) exerts deleterious cardiovascular effects. The effects of ambient PM on vascular function in prediabetic individuals are unclear.Methods:A panel (...) (Hypertension)

22 February

Hypertension https://www.ahajournals.org/

• 11:00
  White-Coat Hypertension Without Organ Damage: Impact on Long-Term Mortality, New Hypertension, and New Organ Damage - Giuseppe Mancia Rita Facchetti Jennifer Vanoli Raffaella Dell’Oro Gino Seravalle Guido Grassi University Milano-Bicocca, Milan (G.M.). Clinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy (R.F., J.V., R.D., G.S., G.G.). Hypertension
  Hypertension, Volume 79, Issue 5, Page 1057-1066, May 1, 2022. Background:According to some guidelines, white-coat hypertension (WCH) carries little or no increase of cardiovascular risk in the absence of organ damage (OD), but no data are available on this issue.Methods:Using the population (...) (Hypertension)
• 11:00
  Expression of LHCGR in Pheochromocytomas Unveils an Endocrine Mechanism Connecting Pregnancy and Epinephrine Overproduction - Antoine-Guy Lopez Céline Duparc Sylvie Renouf Elise Machevin Vincent Le Guillou Jean-Christophe Sabourin Guillaume Defortescu Alexandre Buffet Anne-Paule Gimenez-Roqueplo Christophe Dubessy Estelle Louiset Hervé Lefebvre Normandie University, UNIROUEN, INSERM U1239, NorDiC, Rouen, France (A.-G.L., C. Duparc, S.R., C. Dubessy, E.L., H.L.). Department of Endocrinology, Diabetes and Metabolic Diseases (A.-G.L., H.L.), Rouen University Hospital, Rouen‚ France. Department of Thoracic and Cardiovascular Surgery (V.L.G.), Rouen University Hospital, Rouen‚ France. Department of Pathology and INSERM (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 1006-1016, May 1, 2022. Background:The mechanisms by which pregnancy may unmask pheochromocytomas and paragangliomas are not totally understood. We hypothesized that gestational hormones may participate in the pathophysiology of catecholamine excess during (...) (Hypertension)
• 11:00
  Effect of Sunitinib Treatment on Skin Sodium Accumulation in Patients With Renal Cancer: a Pilot Study - Lajos Markó Anne Dörr Peter Linz Anton H. van den Meiracker Ingrid M. Garrelds Titus Kuehne Ralf Dechend A. H. Jan Danser Anne Flörcken Dominik N. Müller Experimental and Clinical Research Center, a cooperation of Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany (L.M., R.D., D.N.M.). DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany (L.M., D.M.N.). Berlin Institute of Health (BIH), Germany (L.M., R.D., D.N.M.). Charité - Universitätsmedizin Berlin, Germany (L.M., R.D., D.N.M.). Charité–Universitätsmedizin Berlin, (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page e103-e105, May 1, 2022. (Hypertension)

21 February

Hypertension https://www.ahajournals.org/

• 11:00
  Delayed Finalization of Sodium Targets in the United States May Cost Over 250 000 Lives by 2031 - Jing Song Mhairi K. Brown Laura K. Cobb Michael F. Jacobson Nicole Ide Graham A. MacGregor Feng J. He Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (J.S., M.K.B., G.A.M., F.J.H.). Resolve to Save Lives, An Initiative of Vital Strategies, New York City (L.K.C., N.I.). Consultant, Washington, DC (M.F.J.). Hypertension
  Hypertension, Volume 79, Issue 4, Page 798-808, April 1, 2022. Background:The US Food and Drug Administration (FDA) proposed 2- and 10-year voluntary sodium-reduction targets for >150 packaged- and prepared-food categories in 2016 and finalized the short-term targets in 2021.Methods:We modeled (...) (Hypertension)

18 February

Hypertension https://www.ahajournals.org/

• 11:00
  Diastolic Blood Pressure Variability in Later Life May Be a Key Risk Marker for Cognitive Decline - Ruth Peters Ying Xu Ranmalee Eramudugolla Perminder S. Sachdev Nicolas Cherbuin Phillip J. Tully Moyra E. Mortby Kaarin J. Anstey Neuroscience Research Australia, NSW (R.P., Y.X., R.E., M.E.M., K.J.A.). School of Psychology (R.P., Y.X., R.E., M.E.M., K.J.A.), University of New South Wales, Australia. Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry (P.S.S.), University of New South Wales, Australia. Neuropsychiatric Institute, the Prince of Wales Hospital, Sydney, Australia (P.S.S.). Australian National University (N.C.). Adelaide University, Australia (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 1037-1044, May 1, 2022. Background:There is an increasing awareness of the need to understand the interaction between long-term blood pressure patterns and their impact on the brain and cognition.Methods:Our aim was to investigate the relationship between (...) (Hypertension)

16 February

Hypertension https://www.ahajournals.org/

• 11:01
  Nitroxyl Donor CXL-1020 Lowers Blood Pressure by Targeting C195 in Cyclic Guanosine-3’,5’-Monophosphate-Dependent Protein Kinase I - Alisa Kamynina Sebastian Guttzeit Philip Eaton Friederike Cuello William Harvey Research Institute, Queen Mary University of London, United Kingdom (A.K., S.G., P.E.). Institute of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Germany (F.C.). DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, University Medical Center Hamburg-Eppendorf, Germany (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 946-956, May 1, 2022. Background:We previously demonstrated that nitroxyl causes vasodilation, at least in part, by inducing the formation of an intradisulfide bond between C117 and C195 in the high affinity cyclic guanosine monophosphate-binding site of (...) (Hypertension)
• 11:00
  Arterial Stiffness and Long-Term Risk of Health Outcomes: The Framingham Heart Study - Ramachandran S. Vasan Stephanie Pan Vanessa Xanthakis Alexa Beiser Martin G. Larson Sudha Seshadri Gary F. Mitchell Section of Preventive Medicine and Epidemiology (R.S.V., V.X.), Boston University School of Medicine, Boston, MA. Department of Neurology (A.B., S.S.), Boston University School of Medicine, Boston, MA. Framingham Heart Study, MA (R.S.V., V.X., A.B., M.G.L., S.S.). Department of Epidemiology (R.S.V.), Boston University School of Public Health, MA. Department of Biostatistics (S.P., V.X., A.B., M.G.L.), Boston University School of Public Health, MA. Biggs Institute for (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 1045-1056, May 1, 2022. Background:Arterial stiffness increases with age and is associated with an increased risk of adverse outcomes on short-term follow-up (typically (Hypertension)

15 February

Hypertension https://www.ahajournals.org/

• 11:00
  Chronic Kidney Disease and Left Ventricular Hypertrophy. Potent Modifiers of the Prognostic Impact of Circadian Blood Pressure Changes - Paolo Verdecchia Fabio Angeli Gianpaolo Reboldi Fondazione Umbra Cuore e Ipertensione-ONLUS and Division of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy (P.V.). Department of Medicine and Surgery, University of Insubria, Varese (F.A.). Department of Medicine and Cardiopulmonary Rehabilitation, Maugeri Care and Research Institute, IRCCS Tradate, Italy (F.A.). Department of Medicine, Centro di Ricerca Clinica e Traslazionale (CERICLET), University of Perugia, Italy (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 1028-1036, May 1, 2022. Background:It is unclear whether the prognostic value of blood pressure (BP) changes from day to night is modified by concomitant risk factors and organ damage.Methods:We studied 3247 clinically hypertensive patients who underwent (...) (Hypertension)
• 11:00
  Association of Different Definitions of Intradialytic Hypertension With Long-Term Mortality in Hemodialysis - Anika T. Singh Sushrut S. Waikar Finnian R. Mc Causland Renal Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (A.T.S., F.R.M.C.). Harvard Medical School, Boston, MA (A.T.S., F.R.M.C.). Renal Section, Boston Medical Center, MA (S.S.W.). Boston University School of Medicine (S.S.W.). Hypertension
  Hypertension, Volume 79, Issue 4, Page 855-862, April 1, 2022. Background:Hypertension is common in hemodialysis patients. A subset of patients experience systolic blood pressure increases from prehemodialysis to posthemodialysis (intradialytic hypertension), which are associated with adverse (...) (Hypertension)
• 11:00
  Racial Differences in XO (Xanthine Oxidase) and Mitochondrial DNA Damage-Associated Molecular Patterns in Resistant Hypertension - Brittany Butts Jamelle A. Brown Thomas S. Denney Scott Ballinger Steven G. Lloyd Suzanne Oparil Paul Sanders Tony R. Merriman Angelo Gaffo Jasvinder Singh Eric E. Kelley David A. Calhoun Louis J. Dell’Italia Division of Cardiovascular Disease, University of Alabama at Birmingham (UAB) School of Medicine (SOM) (B.B., S.G.L., S.O., P.S., D.A.C., L.J.D.). Center for Free Radical Biology and Department of Pathology, UAB SOM (J.A.B., S.B.). Department of Electrical and Computer Engineering, Auburn University (T.S.D.). Nephrology Research and Training Center and Division of Nephrology UAB SOM (...) Hypertension
  Hypertension, Volume 79, Issue 4, Page 775-784, April 1, 2022. Background:We previously reported increased plasma XO (xanthine oxidase) activity in patients with resistant hypertension. Increased XO can cause mitochondrial DNA damage and promote release of fragments called mitochondrial DNA (...) (Hypertension)

11 February

Hypertension https://www.ahajournals.org/

• 11:00
  Role of Extracellular Vesicles in the Pathogenesis of Vascular Damage - Fabrizio Buffolo Silvia Monticone Giovanni Camussi Elena Aikawa Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences (F.B., S.M.), University of Torino, Italy. Department of Medical Sciences, Molecular Biotechnology Center (G.C.), University of Torino, Italy. Center for Interdisciplinary Cardiovascular Sciences, Department of Cardiovascular Medicine (F.B, E.A.), Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. Center for Excellence in Vascular Biology, Department of Cardiovascular Medicine (E.A.), Brigham and Women’s Hospital, Harvard Medical (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 863-873, May 1, 2022. Extracellular vesicles (EVs) are nanosized membrane-bound structures released by cells that are able to transfer nucleic acids, protein cargos, and metabolites to specific recipient cells, allowing cell-to-cell communications in an (...) (Hypertension)
• 11:00
  Low Chloride–Regulated ClC-5 Contributes to Arterial Smooth Muscle Cell Proliferation and Cerebrovascular Remodeling - Min Gao Ming-Ming Ma Feng-Ting Lu Cheng-Cui Huang Lu Sun Xiao-Fei Lv Bin Zhang Guan-Lei Wang Yong-Yuan Guan Department of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine (M.G., M.-M.M., F.-T.L., C.-C.H., L.S., X.-F.L., G.-L.W., Y.-Y.G.), Sun Yat-Sen University, Guangzhou, China. Department of Pharmacy, The Sixth Affiliated Hospital (M.G., C.-C.H.), Sun Yat-Sen University, Guangzhou, China. Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, (...) Hypertension
  Hypertension, Volume 79, Issue 4, Page e73-e85, April 1, 2022. Background:Low serum chloride (Cl?) level is considered an independent predictor of cardiovascular mortality associated with chronic hypertension. However, the underlying mechanisms are unknown. ClC-5, a member of the Cl?channel (...) (Hypertension)

10 February

Hypertension https://www.ahajournals.org/

• 11:00
  Genetics of Primary Aldosteronism - Ute I. Scholl Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Center of Functional Genomics, Germany. Hypertension
  Hypertension, Volume 79, Issue 5, Page 887-897, May 1, 2022. Primary aldosteronism is considered the commonest cause of secondary hypertension. In affected individuals, aldosterone is produced in an at least partially autonomous fashion in adrenal lesions (adenomas, [micro]nodules or diffuse (...) (Hypertension)
• 11:00
  Aortic Pulse Wave Velocity as Adjunct Risk Marker for Assessing Cardiovascular Disease Risk: Prospective Study - Carlos A. Valencia-Hernández Joni V. Lindbohm Martin J. Shipley Ian B. Wilkinson Carmel M. McEniery Sara Ahmadi-Abhari Archana Singh-Manoux Mika Kivimäki Eric J. Brunner Research Department of Epidemiology and Public Health, University College London, London, United Kingdom (C.A.V.-H., J.V. L., M.J.S., A.S.-M., M.K., E.J.B.). Clinicum, Department of Public Health, University of Helsinki (J.V.L.). Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom (I.B.W., C.M.M.). Ageing Epidemiology Research Unit, Imperial College London, United Kingdom (S.A.-A.). Université de (...) Hypertension
  Hypertension, Volume 79, Issue 4, Page 836-843, April 1, 2022. Background:Aortic pulse wave velocity is a noninvasive measure of aortic stiffness and arterial aging. Its current value in cardiovascular risk estimation practice is unknown. We aimed to establish whether aortic pulse wave velocity (...) (Hypertension)

9 February

Hypertension https://www.ahajournals.org/

• 11:00
  With a Little Help From My Friends: the Role of the Renal Collateral Circulation in Atherosclerotic Renovascular Disease - Jakob Nyvad Amir Lerman Lilach O. Lerman Division of Nephrology and Hypertension (J.N., L.O.L.), Mayo Clinic, Rochester, MN. Department of Cardiovascular Medicine (A.L.), Mayo Clinic, Rochester, MN. Department of Nephrology and Hypertension, Aarhus University Hospital, Aarhus, Denmark (J.N.). Hypertension
  Hypertension, Volume 79, Issue 4, Page 717-725, April 1, 2022. The collateral circulation can adapt to bypass major arteries with limited flow and serves a crucial protective role in coronary, cerebral, and peripheral arterial disease. Emerging evidence indicates that the renal collateral (...) (Hypertension)
• 08:00
  Correction to: Do ?-Blockers Cause Depression? Systematic Review and Meta-Analysis of Psychiatric Adverse Events During ?-Blocker Therapy Hypertension
  Hypertension, Volume 79, Issue 3, Page e72-e72, March 1, 2022. (Hypertension)
• 08:00
  Interrelations Between High Blood Pressure, Organ Damage, and Cardiovascular Disease: No More Room for Doubt - Karri Suvila Teemu J. Niiranen Department of Medicine, Turku University Hospital and University of Turku, Finland (K.S., T.J.N.). Department of Public Health Solutions, Finnish Institute for Health and Welfare, Turku, Finland (T.J.N.). Hypertension
  Hypertension, Volume 79, Issue 3, Page 516-517, March 1, 2022. (Hypertension)
• 08:00
  Great Chinese Famine and the Effects on Cardiometabolic Health for Future Generations - Korbua Srichaikul Robert A. Hegele David J.A. Jenkins Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Ontario, Canada (K.S., D.J.A.J.). Clinical Nutrition Risk Factor Modification Centre, St. Michael’s Hospital, Toronto, Ontario, Canada (K.S., D.J.A.J.). Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada (K.S., D.J.A.J.). Department of Medicine, Western University, London, Ontario, Canada (R.A.H.). Toronto 3D Knowledge Synthesis and Clinical Trials Unit, Ontario, Canada (D.J.A.J.). Li Ka Shing Knowledge Institute (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page 532-535, March 1, 2022. (Hypertension)
• 08:00
  Correction to: Hypertension in Pregnancy: Diagnosis, Blood Pressure Goals, and Pharmacotherapy: A Scientific Statement From the American Heart Association Hypertension
  Hypertension, Volume 79, Issue 3, Page e70-e70, March 1, 2022. (Hypertension)
• 08:00
  Correction to: Calcitonin Gene-Related Peptide Protects Against Cardiovascular Dysfunction Independently of Nitric Oxide In Vivo Hypertension
  Hypertension, Volume 79, Issue 3, Page e71-e71, March 1, 2022. (Hypertension)

7 February

Hypertension https://www.ahajournals.org/

• 11:00
  Acute Induced Pressure Overload Rapidly Incites Thoracic Aortic Aneurysmal Smooth Muscle Cell Phenotype - Albert J. Pedroza Rohan Shad Alex R. Dalal Nobu Yokoyama Ken Nakamura William Hiesinger Michael P. Fischbein Department of Cardiothoracic Surgery, Stanford University School of Medicine, CA. Hypertension
  Hypertension, Volume 79, Issue 4, Page e86-e89, April 1, 2022. (Hypertension)

4 February

Hypertension https://www.ahajournals.org/

• 11:00
  New Noninvasive Methods to Evaluate Microvascular Structure and Function - Damiano Rizzoni Alessandro Mengozzi Stefano Masi Claudia Agabiti Rosei Carolina De Ciuceis Agostino Virdis Clinica Medica, Department of Clinical and Experimental Sciences, University of Brescia, Italy (D.R., C.A., C.D.C.). Division of Medicine, Spedali Civili di Brescia, Montichiari (Brescia), Italy (D.R.). Department of Clinical and Experimental Medicine, University of Pisa, Italy (A.M., S.M., A.V.). Institute of Life Science, Sant’Anna School of Advanced Studies, Pisa, Italy (A.M.). Institute of Cardiovascular Science, University College London, United Kingdom (...) Hypertension
  Hypertension, Volume 79, Issue 5, Page 874-886, May 1, 2022. The structural and functional alterations of microvessels are detected because of physiological aging and in several cardiometabolic diseases, including hypertension, diabetes, and obesity. The small resistance arteries of these (...) (Hypertension)
• 11:01
  Influence of Baseline Diastolic Blood Pressure on the Effects of Intensive Systolic Blood Pressure Lowering on the Risk of Stroke - Saeed Shihab Robert E. Boucher Nikita Abraham Guo Wei Srinivasan Beddhu Division of Nephrology & Hypertension, University of Utah School of Medicine, Salt Lake City (S.S., R.E.B., N.A., G.W., S.B.). Medical Service, Veterans Affairs Salt Lake City Health Care System (S.B.). Hypertension
  Hypertension, Volume 79, Issue 4, Page 785-793, April 1, 2022. Background:Guidelines recommend lowering systolic blood pressure below 130 mm Hg, irrespective of previous strokes. However, there is a concern that lowering systolic blood pressure in people with low baseline diastolic blood (...) (Hypertension)

3 February

Hypertension https://www.ahajournals.org/

• 11:00
  Regulation of Blood Pressure and Salt Balance By Pendrin-Positive Intercalated Cells: Donald Seldin Lecture 2020 - Susan M. Wall Department of Medicine, Emory University School of Medicine, Atlanta, GA. Hypertension
  Hypertension, Volume 79, Issue 4, Page 706-716, April 1, 2022. Intercalated cells make up about a third of all cells within the connecting tubule and the collecting duct and are subclassified as type A, type B and non-A, non-B based on the subcellular distribution of the H+-ATPase, which (...) (Hypertension)

31 January

Hypertension https://www.ahajournals.org/

• 11:00
  Immune System and Microvascular Remodeling in Humans - Damiano Rizzoni Carolina De Ciuceis Piotr Szczepaniak Pierre Paradis Ernesto L. Schiffrin Tomasz J. Guzik Clinica Medica, Department of Clinical and Experimental Sciences, University of Brescia, Italy (D.R., C.D.C.). Division of Medicine, Spedali Civili di Brescia, Montichiari, Italy (D.R.). Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (P.S., T.J.G.). Department of Medicine, Jagiellonian University Medical College, Krakow, Poland (P.S., T.J.G.). Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, Montreal, Québec, (...) Hypertension
  Hypertension, Volume 79, Issue 4, Page 691-705, April 1, 2022. Low-grade inflammatory processes and related oxidative stress may have a key role in the pathogenesis of hypertension and hypertension-mediated organ damage. Innate immune cells, such as neutrophils, dendritic cells, (...) (Hypertension)
• 11:00
  Exploring Overweight Risk Trajectories During Childhood and Their Associations With Elevated Blood Pressure at Late Adolescence: a Retrospective Cohort Study - Xijie Wang Jie Hu Sizhe Huang Zhaogeng Yang Yanhui Dong Bin Dong Jun Ma Wannian Liang Vanke School of Public Health, Tsinghua University, Beijing, China. (X.W., W.L.) Institute for Healthy China, Tsinghua University, Beijing, China. (X.W., W.L.) Institute of Child and Adolescent Health, School of Public Health, Peking University Health Science Center, Beijing, China (X.W., Z.Y., Y.D., B.D., J.M.). Menzies Health Institute Queensland, Griffith University, Australia (J.H.). Zhongshan Health Care Centers for Primary and Secondary School, Guangdong, China (...) Hypertension
  Hypertension, Ahead of Print. Background:Overweight during childhood is significantly associated with higher risk of high blood pressure (HBP) in later life. However, recognition of critical intervention period is limited. We aimed to analyze the changes in overweight risk during school-age and (...) (Hypertension)

24 January

Hypertension https://www.ahajournals.org/

• 11:00
  Primary Aldosteronism: Where Are We Now? Where to From Here? - John W. Funder Robert M. Carey Hudson Institute of Medical Research, Monash University, Clayton, Victoria, Australia. Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville. Hypertension
  Hypertension, Volume 79, Issue 4, Page 726-735, April 1, 2022. Primary aldosteronism, the most common secondary form of hypertension, is thought to be present in ?5% to 10% of hypertensive adults. However, recent studies indicate that its prevalence may be at least 3-fold higher based on the (...) (Hypertension)

20 January

Hypertension https://www.ahajournals.org/

• 11:00
  MANP (M-Atrial Natriuretic Peptide) Reduces Blood Pressure and Furosemide-Induced Increase in Aldosterone in Hypertension - Nina A. Dzhoyashvili Seethalakshmi R. Iyer Horng H. Chen John C. Burnett Cardiorenal Research Laboratory, Department of Cardiovascular Medicine (N.A.D., S.R.I., H.H.C., J.C.B.), Mayo Clinic, Rochester, MN. Department of Physiology and Biomedical Engineering (J.C.B.), Mayo Clinic, Rochester, MN. Hypertension
  Hypertension, Volume 79, Issue 4, Page 750-760, April 1, 2022. Background:cGMP MANP (M-atrial natriuretic peptide) is a best-in-class activator of the pGC-A (particulate guanylyl cyclase A) receptor. Furosemide increases the effectiveness of antihypertensive agents, but activates (...) (Hypertension)
• 11:00
  Characterization of Potassium-Induced Natriuresis in Hypertensive Postmenopausal Women During Both Low and High Sodium Intake - Richard A. Preston David Afshartous Evelyn V. Caizapanta Barry J. Materson Rolando Rodco Eileen Alonso Alberto B. Alonso Clinical Pharmacology Research Unit, Division of Clinical Pharmacology, Department of Medicine (R.A.P., D.A., E.V.C., B.J.M., R.R., E.A., A.B.A.), Miller School of Medicine, University of Miami, FL. University of Miami Clinical and Translational Science Institutes (CTSI) (R.A.P.), Miller School of Medicine, University of Miami, FL. The Peggy and Harold Katz Family Drug Discovery center (R.A.P.), Miller School of Medicine, University of Miami, (...) Hypertension
  Hypertension, Volume 79, Issue 4, Page 813-826, April 1, 2022. Background:Potassium-induced natriuresis may contribute to the beneficial effects of potassium on blood pressure but has not been well-characterized in human postmenopausal hypertension. We determined the time course and magnitude (...) (Hypertension)
• 11:00
  DPP4 (Dipeptidyl Peptidase-4) Inhibition Increases Catecholamines Without Increasing Blood Pressure During Sustained ACE (Angiotensin-Converting Enzyme) Inhibitor Treatment - Jessica R. Wilson Erica M. Garner Mona Mashayekhi Scott A. Hubers Claudia E. Ramirez Bustamante Scott Jafarian Kerman Hui Nian Cyndya A. Shibao Nancy J. Brown Division of Clinical Pharmacology (J.R.W., S.A.H., C.E.R.B., S.J.K., N.J.B.), Vanderbilt Department of Medicine. Division of Endocrinology, Diabetes, and Metabolism (J.R.W., E.M.G., M.M.), Vanderbilt Department of Medicine. Division of Clinical Pharmacology (C.A.S.), Vanderbilt Department of Medicine. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Mayo Clinic Florida (J.R.W.). Division of Cardiology, (...) Hypertension
  Hypertension, Volume 79, Issue 4, Page 827-835, April 1, 2022. Background:DPP4 (dipeptidyl peptidase-4) inhibitors comprise a class of oral diabetes medication that have the potential for off-target cardiovascular effects. We previously showed that DPP4 inhibition attenuates the hypotensive (...) (Hypertension)

18 January

Hypertension https://www.ahajournals.org/

• 11:00
  Effect of Arterial Stiffness and Carotid Intima-Media Thickness Progression on the Risk of Dysglycemia, Insulin Resistance, and Dyslipidemia: a Temporal Causal Longitudinal Study - Andrew O. Agbaje Alan R. Barker Gary F. Mitchell Tomi-Pekka Tuomainen Institute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (A.O.A., T.-P.T). Children’s Health and Exercise Research Centre, Sport and Health Sciences, University of Exeter, United Kingdom (A.R.B.). Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.). Hypertension
  Hypertension, Volume 79, Issue 3, Page 667-678, March 1, 2022. Background:We investigated the temporal causal longitudinal associations of carotid-femoral pulse wave velocity (cfPWV), a measure of arterial stiffness, and carotid intima-media thickness (cIMT) progression with the risk of (...) (Hypertension)

14 January

Hypertension https://www.ahajournals.org/

• 11:00
  Mineralocorticoid Receptor Antagonist Use and Hard Renal Outcomes in Real-World Patients With Chronic Kidney Disease - Tatsufumi Oka Yusuke Sakaguchi Koki Hattori Yuta Asahina Sachio Kajimoto Yohei Doi Jun-Ya Kaimori Yoshitaka Isaka Department of Nephrology (T.O., K.H., Y.A., S.K., Y.D., Y.I.), Osaka University Graduate School of Medicine, Osaka, Japan. Department of Inter-Organ Communication Research in Kidney Disease (Y.S., J.-Y.K.), Osaka University Graduate School of Medicine, Osaka, Japan. Hypertension
  Hypertension, Volume 79, Issue 3, Page 679-689, March 1, 2022. Background:Real-world evidence about mineralocorticoid receptor antagonist (MRA) use has been limited in chronic kidney disease, particularly regarding its association with hard renal outcomes.Methods:In this retrospective cohort (...) (Hypertension)

13 January

Hypertension https://www.ahajournals.org/

• 11:00
  Carotid Artery Stiffness Mechanisms Associated With Cardiovascular Disease Events and Incident Hypertension: the Multi-Ethnic Study of Atherosclerosis (MESA) - Ryan J. Pewowaruk Claudia Korcarz Yacob Tedla Gregory Burke Philip Greenland Colin Wu Adam D. Gepner University of Wisconsin School of Medicine and Public Health, Madison (R.J.P., C.K., A.D.G.). William S. Middleton Memorial Veteran’s Hospital, Madison, WI (R.J.P., A.D.G.). Vanderbilt University School of Medicine, Nashville, TN (Y.T.). Wake Forest School of Medicine, Winston-Salem, NC (G.B.). Northwestern University Feinberg School of Medicine, Chicago, IL (P.G.). National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page 659-666, March 1, 2022. Background:Elastic arteries stiffen via 2 main mechanisms: (1) load-dependent stiffening from higher blood pressure and (2) structural stiffening due to changes in the vessel wall. It is unknown how these different mechanisms (...) (Hypertension)

12 January

Hypertension https://www.ahajournals.org/

• 11:00
  Higher Plasma Aldosterone Concentrations Are Associated With Elevated Risk of Aortic Dissection and Aneurysm: a Case-Control Study - Qing Zhu Mulalibieke Heizhati Mengyue Lin Menghui Wang Xiaoguang Yao Lin Gan Qin Luo Weiwei Zhang Jing Hong Na Yue Nanfang Li Hypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Key Laboratory of Xinjiang Uygur Autonomous Region “Hypertension Research Laboratory, Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) (...) Hypertension
  Hypertension, Volume 79, Issue 4, Page 736-746, April 1, 2022. Background:Animal models demonstrate circulating aldosterone leads to aortic dissection and aneurysm, whereas data from humans are lacking. Therefore, we aimed to examine the associations of plasma aldosterone concentrations (PAC) (...) (Hypertension)
• 08:16
  Optimal Screening for Preeclampsia in the First Trimester of Pregnancy - Emmanuel Bujold Research Center of CHU de Québec-Université Laval, Canada. Department of Obstetrics and Gynecology, Faculty of Medicine, Université Laval, Québec, Canada. Hypertension
  Hypertension, Volume 79, Issue 2, Page 323-324, February 1, 2022. (Hypertension)
• 08:16
  Race and Antihypertensive Drug Therapy: Edging Closer to a New Paradigm - John Mark Flack Michael Gregory Buhnerkempe Department of Medicine, Division of General Internal Medicine, Hypertension Section (J.M.F.), Southern Illinois University. Department of Medicine and the Center for Clinical Research (M.G.B.), Southern Illinois University. Hypertension
  Hypertension, Volume 79, Issue 2, Page 349-351, February 1, 2022. (Hypertension)

11 January

Hypertension https://www.ahajournals.org/

• 11:00
  RNA Modification Signature of Peripheral Blood as a Potential Diagnostic Marker for Pulmonary Hypertension - Liwen Zhang Yuzhu Li Jian Wang Cheng Hong Wenju Lu Yongcun Qu Stephen M. Black Qi Chen Tong Zhou Wanzhu Jin Enkui Duan Haiyang Tang Ying Zhang Institute of Zoology, Chinese Academy of Sciences, Beijing, China (L.Z., Y.Q., W.J., E.D.). The Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Sciences, Beijing Normal University, China (Y.Z.). University of Chinese Academy of Sciences, Beijing, China (L.Z., Y.Q.). State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page e67-e69, March 1, 2022. (Hypertension)

10 January

Hypertension https://www.ahajournals.org/

• 11:00
  Comparative Studies of Renin-Null Zebrafish and Mice Provide New Functional Insights - Scott Hoffmann Linda Mullins Sebastien Rider Cara Brown Charlotte B. Buckley Adrienne Assmus Ziwen Li Mariana Sierra Beltran Neil Henderson Jorge del Pozo Alexandre De Goes Martini Maria Luisa S. Sequeira-Lopez R. Ariel Gomez John Mullins Centre for Cardiovascular Science (S.H., L.M., S.R., C.B., C.B.B., A.A., Z.L., J.M.), The Queen’s Medical Research Institute, The University of Edinburgh, United Kingdom. Centre for Inflammation Research (M.S.B., N.H.), The Queen’s Medical Research Institute, The University of Edinburgh, United Kingdom. Now with DSM Nutritional Products Ltd, Switzerland (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page e56-e66, March 1, 2022. Background:The renin-angiotensin system is highly conserved across vertebrates, including zebrafish, which possess orthologous genes coding for renin-angiotensin system proteins, and specialized mural cells of the kidney arterioles, (...) (Hypertension)

7 January

Hypertension https://www.ahajournals.org/

• 11:00
  Unique Associations of DNA Methylation Regions With 24-Hour Blood Pressure Phenotypes in Black Participants - Michelle L. Roberts Theodore A. Kotchen Xiaoqing Pan Yingchuan Li Chun Yang Pengyuan Liu Tao Wang Purushottam W. Laud Thomas H. Chelius Yannick Munyura David L. Mattson Yong Liu Allen W. Cowley Srividya Kidambi Mingyu Liang Center of Systems Molecular Medicine, Department of Physiology (M.L.R., X.P., Y.L., C.Y., P.L., F.L.M., A.W.C., M.L.), Medical College of Wisconsin, Milwaukee. Department of Medicine (T.A.K., Y.M., S.K.), Medical College of Wisconsin, Milwaukee. Division of Biostatistics, Institute for Health and Equity (P.W.L.), Medical College of Wisconsin, Milwaukee. Division of (...) Hypertension
  Hypertension, Volume 79, Issue 4, Page 761-772, April 1, 2022. Background:Epigenetic marks (eg, DNA methylation) may capture the effect of gene-environment interactions. DNA methylation is involved in blood pressure (BP) regulation and hypertension development; however, no studies have (...) (Hypertension)
• 11:00
  Superiority of 24-Hour Aortic Over 24-Hour Brachial Pressure to Associate With Carotid Arterial Damage on the Basis of Pressure Amplification Variability: the SAFAR Study - Antonios A. Argyris Dimitrios Mouziouras Stamatia Samara Yi Zhang Marios K. Georgakis Jacques Blacher Michel Safar Petros P. Sfikakis Athanase D. Protogerou Cardiovascular Prevention and Research Unit, Clinic/Laboratory of Pathophysiology, Laiko Hospital, Medical School, National and Kapodistrian University of Athens, Greece (A.A.A., D.M., S.S., A.D.P.). Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China (Y.Z.). Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Germany (M.K.G.). Université de Paris; (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page 648-658, March 1, 2022. Background:Evidence suggests marginal superiority of static aortic systolic blood pressure (aSBP) compared with brachial SBP (bSBP) regarding the association with organ damage and prognosis of cardiovascular disease (CVD). The (...) (Hypertension)

6 January

Hypertension https://www.ahajournals.org/

• 08:06
  Mitigating Initial Orthostatic Hypotension: Mechanistic Roles of Muscle Contraction Versus Sympathetic Activation - Nasia A. Sheikh Aaron A. Phillips Shaun Ranada Matthew Lloyd Karolina Kogut Kate M. Bourne Juliana G. Jorge Lucy Y. Lei Robert S. Sheldon Derek V. Exner Mary Runte Satish R. Raj Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine (N.A.S., A.A.P., S.R., M.L., K.K., K.M.B., J.G.J., L.Y.L., R.S.S., D.V.E., S.R.R.), University of Calgary, AB, Canada. Departments of Physiology and Pharmacology and Clinical Neuroscience (A.A.P.), University of Calgary, AB, Canada. Department of Management, University of Lethbridge, Alberta, Canada (M.R.). Division of (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page 638-647, March 1, 2022. Background:Initial orthostatic hypotension (IOH) is defined by a large drop in blood pressure (BP) within 15 s of standing. IOH often presents during an active stand, but not with a passive tilt, suggesting that a muscle activation (...) (Hypertension)

5 January

Hypertension https://www.ahajournals.org/

• 11:00
  Caspase-4/11–Mediated Pulmonary Artery Endothelial Cell Pyroptosis Contributes to Pulmonary Arterial Hypertension - Yusi Wu Bingjie Pan Zhen Zhang Xiaohui Li Yiping Leng Yong Ji Kun Sun Alex F. Chen Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China (Y.W., X.L.). Center for Vascular Disease and Translational Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China (Y.W., Z.Z., Y.L., A.F.C.). Liuzhou Maternal and Child Healthcare Hospital, Liuzhou, Guangxi, China (B.P.). The Affiliated Changsha Central Hospital, Research Center for Phase I Clinical Trials, Hengyang Medical School, University of South China, Changsha, Hunan, China (Y.L.). (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page 536-548, March 1, 2022. Background:Endothelial dysfunction enhances vascular inflammation, which initiates pulmonary arterial hypertension (PAH) pathogenesis, further induces vascular remodeling and right ventricular failure. Activation of inflammatory (...) (Hypertension)
• 11:00
  Microcirculation and Macrocirculation in Hypertension: A Dangerous Cross-Link? - Stephane Laurent Claudia Agabiti-Rosei Rosa Maria Bruno Damiano Rizzoni Université de Paris, France (S.L., R.M.B.). Department of Pharmacology, Georges Pompidou European Hospital, Assistance-Publique Hopitaux de Paris, France (S.L., R.M.B.). INSERM U970, Cardiovascular Research Center-PARCC, Paris, France (S.L., R.M.B.). Department of Clinical and Experimental Sciences, Clinica Medica, University of Brescia, Italy (C.A.-R., D.R.). Division of Medicine, Spedali Civili di Brescia, Montichiari, Italy (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page 479-490, March 1, 2022. Microcirculation and macrocirculation are tightly interconnected into a dangerous cross-link in hypertension. Small artery damage includes functional (vasoconstriction, impaired vasodilatation) and structural abnormalities (mostly (...) (Hypertension)
• 11:00
  COMP (Cartilage Oligomeric Matrix Protein), a Novel PIEZO1 Regulator That Controls Blood Pressure - Hui Wang Ze Yuan Bianbian Wang Bochuan Li Huizhen Lv Jinlong He Yaqian Huang Zhen Cui Qiannan Ma Ting Li Yi Fu Xiaoli Tan Yangping Liu Shengpeng Wang Changhe Wang Wei Kong Yi Zhu Tianjin Key Laboratory of Metabolic Diseases; Collaborative Innovation Center of Tianjin for Medical Epigenetics and Department of Physiology and Pathophysiology, Tianjin Medical University, China (H.W., Z.Y., B.L., H.L., J.H., Z.C., Q.M., Y.Z.). Neuroscience Research Center, Institute of Mitochondrial Biology and Medicine, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page 549-561, March 1, 2022. Background:Vascular endothelial cells are critical for maintaining blood pressure (BP) by releasing biologically active molecules, such as nitric oxide. A non-endothelial cell resident matricellular protein, COMP (cartilage (...) (Hypertension)

4 January

Hypertension https://www.ahajournals.org/

• 11:00
  Maternal Hypertension Increases Risk of Preeclampsia and Low Fetal Birthweight: Genetic Evidence From a Mendelian Randomization Study - Maddalena Ardissino Eric A.W. Slob Ophelia Millar Rohin K. Reddy Laura Lazzari Kiran Haresh Kumar Patel David Ryan Mark R. Johnson Dipender Gill Fu Siong Ng National Heart and Lung Institute (M.A., O.M., R.K.R., L.L., K.H.K.P., F.S.N.), Imperial College London, United Kingdom. Division of Reproductive and Developmental Biology, Department of Metabolism, Digestion and Reproduction (M.R.J.), Imperial College London, United Kingdom. Department of Biostatistics and Epidemiology, School of Public Health (D.G.), Imperial College London, United Kingdom. Nuffield Department of Population Health, (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page 588-598, March 1, 2022. Background:Maternal cardiovascular risk factors have been associated with adverse maternal and fetal outcomes. Given the difficulty in establishing causal relationships using epidemiological data, we applied Mendelian randomization (...) (Hypertension)
• 11:00
  Oral Antihypertensives for Nonsevere Pregnancy Hypertension: Systematic Review, Network Meta- and Trial Sequential Analyses - Jeffrey N. Bone Akshdeep Sandhu Edgardo D. Abalos Asma Khalil Joel Singer Sarina Prasad Shazmeen Omar Marianne Vidler Peter von Dadelszen Laura A. Magee Department of Obstetrics and Gynaecology, University of British Columbia (UBC), Canada (J.N.B., A.S., S.P., S.O., M.V.). Centro Rosarino de Estudios Perinatales, Rosario, Argentina (E.D.A.). Fetal Medicine Unit, Department of Obstetrics and Gynaecology, St George’s University Hospitals, NHS Foundation Trust, United Kingdom (A.K.). Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George’s University of (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page 614-628, March 1, 2022. Background:We aimed to address which antihypertensives are superior to placebo/no therapy or another antihypertensive for controlling nonsevere pregnancy hypertension and provide future sample size estimates for definitive (...) (Hypertension)

30 December

Hypertension https://www.ahajournals.org/

• 11:00
  CCN2 (Cellular Communication Network Factor 2) Deletion Alters Vascular Integrity and Function Predisposing to Aneurysm Formation - Raúl R. Rodrigues-Díez Antonio Tejera-Muñoz Vanesa Esteban Lasse B. Steffensen Raquel Rodrigues-Díez Macarena Orejudo Sandra Rayego-Mateos Lucas L. Falke Pablo Cannata-Ortiz Alberto Ortiz Jesus Egido Ziad Mallat Ana M. Briones M. Auxiliadora Bajo Roel Goldschmeding Marta Ruiz-Ortega Molecular and Cellular Biology in Renal and Vascular Pathology, IIS-Fundación Jiménez Díaz-Universidad Autónoma Madrid, Spain (R.R.R.-D., A.T.-M., M.O., S.R.-M., M.R.-O.). Red de Investigación Renal, Instituto de Salud Carlos III, Madrid, Spain (R.R.R.-D., M.O., S.R.-M., P.C.-O., A.O., M.A.B., M.R.-O.). Department of (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page e42-e55, March 1, 2022. Background:CCN2 (cellular communication network factor 2) is a matricellular protein involved in cell communication and microenvironmental signaling responses. CCN2 is known to be overexpressed in several cardiovascular diseases, (...) (Hypertension)
• 11:02
  Visit-to-Visit Blood Pressure Variability and Longitudinal Tau Accumulation in Older Adults - Isabel J. Sible Daniel A. Nation Department of Psychology, University of Southern California, Los Angeles (I.J.S.). Institute for Memory Impairments and Neurological Disorders (D.A.N.), University of California Irvine. Department of Psychological Science (D.A.N.), University of California Irvine., for the Alzheimer’s Disease Neuroimaging Initiative* Michael Weiner Paul Aisen Ronald Petersen Clifford R. Jack William Jagust John Q. Trojanowki Arthur W. Toga Laura Beckett Robert C. Green Andrew J. Saykin John Morris Leslie M. (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page 629-637, March 1, 2022. Background:Elevated blood pressure variability (BPV) is predictive of dementia, independent of average blood pressure levels, but neuropathological mechanisms remain unclear. We examined whether BPV in older adults is related to tau (...) (Hypertension)
• 11:00
  Methodological Aspects of Meta-Analyses Assessing the Effect of Blood Pressure–Lowering Treatment on Clinical Outcomes - Mattias Brunström Costas Thomopoulos Bo Carlberg Reinhold Kreutz Giuseppe Mancia Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden (M.B., B.C.). Department of Cardiology, Helena Venizelou Hospital, Athens, Greece (C.T.). Charité – Universitätsmedizin Berlin, Institute of Clinical Pharmacology and Toxicology, Charitéplatz 1, Berlin, Germany (R.K.). University of Milano-Bicocca, Milan, Italy (G.M.). Hypertension
  Hypertension, Volume 79, Issue 3, Page 491-504, March 1, 2022. Systematic reviews and meta-analyses are often considered the highest level of evidence, with high impact on clinical practice guidelines. The methodological literature on systematic reviews and meta-analyses is extensive and covers (...) (Hypertension)
• 11:00
  Examining the Development of Chronic Thromboembolic Pulmonary Hypertension at the Single-Cell Level - Ran Miao Xingbei Dong Juanni Gong Yidan Li Xiaojuan Guo Jianfeng Wang Qiang Huang Ying Wang Jifeng Li Suqiao Yang Tuguang Kuang Min Liu Jun Wan Zhenguo Zhai Jiuchang Zhong Yuanhua Yang Medical Research Center (R.M.), Beijing Chao-Yang Hospital, Capital Medical University, China. Department of Respiratory and Critical Care Medicine (R.M., J.G., J.L., S.Y., T.K., Y.Y.), Beijing Chao-Yang Hospital, Capital Medical University, China. Department of Echocardiography (Y.L.), Beijing Chao-Yang Hospital, Capital Medical University, China. Department of Radiology (X.G.), Beijing Chao-Yang Hospital, (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page 562-574, March 1, 2022. Background:The mechanism of chronic thromboembolic pulmonary hypertension (CTEPH) is known to be multifactorial but remains incompletely understood.Methods:In this study, single-cell RNA sequencing, which facilitates the (...) (Hypertension)

29 December

Hypertension https://www.ahajournals.org/

• 11:00
  Early Pregnancy Blood Pressure Patterns Identify Risk of Hypertensive Disorders of Pregnancy Among Racial and Ethnic Groups - Erica P. Gunderson Mara Greenberg Mai N. Nguyen-Huynh Cassidy Tierney James M. Roberts Alan S. Go Wei Tao Stacey E. Alexeeff Division of Research, Kaiser Permanente Northern California, Oakland, CA (E.P.G., M.N.N.-H., A.S.G., W.T., S.E.A.) the Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA (E.P.G., A.S.G.). Department of Obstetrics and Gynecology, Kaiser Permanente, Oakland Medical Center, CA (M.G., C.T.). Department of Neurology, Kaiser Permanente Walnut Creek Medical Center, Walnut Creek, CA (M.N.N.-H.). Magee-Womens Research (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page 599-613, March 1, 2022. Background:Hypertensive disorders of pregnancy are a leading cause of severe maternal morbidity and mortality and confer 4-fold higher perinatal mortality in Black women. Early pregnancy blood pressure patterns may differentiate (...) (Hypertension)

28 December

Hypertension https://www.ahajournals.org/

• 11:00
  Cardiac Left Ventricle Mitochondrial Dysfunction After Neonatal Exposure to Hyperoxia: Relevance for Cardiomyopathy After Preterm Birth - Daniela Ravizzoni Dartora Adrien Flahault Carolina N.R. Pontes Ying He Alyson Deprez Anik Cloutier Gaël Cagnone Perrine Gaub Gabriel Altit Jean-Luc Bigras Jean-Sébastien Joyal Thuy Mai Luu Yan Burelle Anne Monique Nuyt Department of Pediatrics, Sainte-Justine University Hospital (Centre Hospitalier Universitaire Sainte-Justine) and Research Centre (D.R.D., A.F., C.N.R.P., Y.H., A.D., A.C., G.C., P.G., J.-L.B., J.-S.J., T.M.L., A.M.N.), Faculty of Medicine, University of Montreal, Quebec, Canada. Department of Physiology and Pharmacology (G.C., P.G., J.-S.J.), Faculty of Medicine, University (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page 575-587, March 1, 2022. Background:Individuals born preterm present left ventricle changes and increased risk of cardiac diseases and heart failure. The pathophysiology of heart disease after preterm birth is incompletely understood. Mitochondria (...) (Hypertension)

27 December

Hypertension https://www.ahajournals.org/

• 11:00
  Borderline and Hypertension - Scott Leopold Rhian Touyz Anna F. Dominiczak Joseph T. Flynn Anna Szyndler Justin P. Zachariah Section of Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX (S.L., J.P.Z.). BHF Glasgow Cardiovascular Research Centre (R.T.), Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom. College of Medical, Veterinary and Life Sciences (A.F.D.), Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom. Department of Pediatrics, University of Washington School of Medicine, (...) Hypertension
  Hypertension, Volume 79, Issue 2, Page 468-473, February 1, 2022. (Hypertension)

15 December

Hypertension https://www.ahajournals.org/

• 11:00
  Hypertension in Pregnancy: Diagnosis, Blood Pressure Goals, and Pharmacotherapy: A Scientific Statement From the American Heart Association - Vesna D. Garovic Ralf Dechend Thomas Easterling S. Ananth Karumanchi Suzanne McMurtry Baird Laura A. Magee Sarosh Rana Jane V. Vermunt Phyllis August Hypertension
  Hypertension, Volume 79, Issue 2, Page e21-e41, February 1, 2022. Hypertensive disorders of pregnancy (HDP) remain one of the major causes of pregnancy-related maternal and fetal morbidity and mortality worldwide. Affected women are also at increased risk for cardiovascular disease later in (...) (Hypertension)

10 December

Hypertension https://www.ahajournals.org/

• 13:55
  Nighttime Home Blood Pressure Is Associated With the Cardiovascular Disease Events Risk in Treatment-Resistant Hypertension - Keisuke Narita Satoshi Hoshide Kazuomi Kario Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan. Hypertension
  Hypertension, Volume 79, Issue 2, Page e18-e20, February 1, 2022. (Hypertension)

9 December

Hypertension https://www.ahajournals.org/

• 11:01
  Hypertension With Negative Metaiodobenzylguanidine Scintigraphy - Antoine-Guy Lopez Anna F. Dominiczak Rhian Touyz Markus Schlaich Jean-Baptiste de Freminville Laurence Amar Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Unité Hypertension Artérielle, Paris, France (A.-G.L., J.-B.d.F., L.A.). Normandie Univ, UNIROUEN, INSERM U1239, Rouen University Hospital, Department of Endocrinology, Diabetology and Metabolic Diseases, Rouen, France (A.-G.L.). Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (A.F.D.), University of Glasgow, United Kingdom. Institute of Cardiovascular and Medical (...) Hypertension
  Hypertension, Volume 79, Issue 2, Page 474-478, February 1, 2022. (Hypertension)
• 11:00
  Maternal Vascular Lesions in the Placenta Predict Vascular Impairments a Decade After Delivery - Janet M. Catov Matthew F. Muldoon Robin E. Gandley Judith Brands Alisse Hauspurg Carl A. Hubel Marie Tuft Mandy Schmella Gong Tang W. Tony Parks Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, School of Medicine, University of Pittsburgh, Magee-Womens Research Institute, Pittsburgh PA (J.M.C., R.E.G., J.B., A.H., C.A.H.). Department of Epidemiology, Graduate School of Public Health (J.M.C.), University of Pittsburgh, PA. Graduate School of Public Health (M.T., G.T.), University of Pittsburgh, PA. School of Nursing (M.S.), University of Pittsburgh, PA. (...) Hypertension
  Hypertension, Volume 79, Issue 2, Page 424-434, February 1, 2022. Women with adverse pregnancy outcomes later experience excess hypertension and cardiovascular disease, but how the events are linked is unknown. Examination of the placenta may provide clues to vascular impairments after (...) (Hypertension)
• 11:00
  Transcriptomic Response in the Heart and Kidney to Different Types of Antihypertensive Drug Administration - Fumihiko Takeuchi Yi-Qiang Liang Masato Isono Mia Yang Ang Kotaro Mori Norihiro Kato Department of Gene Diagnostics and Therapeutics (F.T., Y.-Q.L., M.I., M.Y.A., N.K.), Research Institute, National Center for Global Health and Medicine, Japan. Medical Genomics Center (F.T., K.M., N.K.), Research Institute, National Center for Global Health and Medicine, Japan. Department of Clinical Genome Informatics, Graduate School of Medicine, The University of Tokyo, Japan (M.Y.A., (...) Hypertension
  Hypertension, Volume 79, Issue 2, Page 413-423, February 1, 2022. Certain classes of antihypertensive drug may exert specific, blood pressure (BP)-independent protective effects on end-organ damages such as left ventricular hypertrophy, although the overall evidence has not been definitive in (...) (Hypertension)

8 December

Hypertension https://www.ahajournals.org/

• 08:00
  Effectiveness of a Workplace-Based, Multicomponent Hypertension Management Program in Real-World Practice: A Propensity-Matched Analysis - Yan-Feng Zhou Simiao Chen Guodong Wang Shuohua Chen Yan-Bo Zhang Jun-Xiang Chen Zhou-Zheng Tu Gang Liu Shouling Wu An Pan Department of Epidemiology and Biostatistics, and Ministry of Education Key Lab of Environment and Health (Y.-F.Z., Y.-B.Z., J.-X.C., Z.-Z.T., A.P.), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Department of Nutrition and Food Hygiene, and Hubei Key Laboratory of Food Nutrition and Safety (G.L.), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 230-240, January 1, 2022. Limited studies had investigated the potential benefits of workplace-based hypertension management programs on long-term blood pressure (BP) control and health outcomes. This study used the propensity score matching to examine the (...) (Hypertension)
• 08:00
  Editors and Editorial Board Hypertension
  Hypertension, Volume 79, Issue 1, Page 1-2, January 1, 2022. (Hypertension)
• 08:00
  How Low Should You Go in the Presence of Frailty? - Michelle C. Odden Timothy S. Anderson Department of Epidemiology and Population Health, Stanford University, CA (M.C.O). Geriatric Research and Education Clinical Center, VA Palo Alto Health Care System, CA (M.C.O.). Division of General Medicine, Beth Israel Deaconess Medical Center, Boston, MA (T.S.A.). Hypertension
  Hypertension, Volume 79, Issue 1, Page 33-35, January 1, 2022. (Hypertension)
• 08:00
  Sex Differences in Hypertension: Related to Genes, Jean Sizes, and Salt Sensitivity? - Michael E. Hall John E. Hall From the Department of Medicine (M.E.H.), University of Mississippi Medical Center. Department of Physiology and Biophysics (M.E.H., J.E.H.), University of Mississippi Medical Center. Hypertension
  Hypertension, Volume 79, Issue 1, Page 47-49, January 1, 2022. (Hypertension)
• 08:00
  Evaluation and Diagnosis of Afferent Baroreflex Failure - Italo Biaggioni Cyndya A. Shibao Jens Jordan Autonomic Dysfunction Center and Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (I.B., C.A.S.). Institute of Aerospace Medicine, German Aerospace Center (German Aerospace Center) and University of Cologne, Germany (J.J.). Hypertension
  Hypertension, Volume 79, Issue 1, Page 57-59, January 1, 2022. (Hypertension)
• 08:00
  Comorbidities Caused by a Corrupt Cullin 3: Lessons Learned From Bedside to Bench - Jing Wu Curt D. Sigmund Department of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee. Hypertension
  Hypertension, Volume 79, Issue 1, Page 76-78, January 1, 2022. (Hypertension)

7 December

Hypertension https://www.ahajournals.org/

• 11:00
  Famine and Trajectories of Body Mass Index, Waist Circumference, and Blood Pressure in Two Generations: Results From the CHNS From 1993–2015 - Jie Li Qingling Yang Ran An Howard D. Sesso Victor W. Zhong Kei Hang Katie Chan Tracy E. Madsen George D. Papandonatos Tongzhang Zheng Wen-Chih Wu Yan Song Xueqing Yu Simin Liu From the Global Health Research Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China (J.L., Q.Y., X.Y.) Department of Epidemiology and Center for Global Cardiometabolic Health (J.L., K.H.K.C., T.E.M., T.Z., W.-C.W., Y.S., S.L.), School of Public Health, Brown University, Providence, RI Department of Biostatistics (G.D.P.), School of Public Health, Brown University, (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page 518-531, March 1, 2022. Background:Early-life exposures play key roles in the development of metabolic diseases. Whether such effects exist beyond one generation remains unclear. This study aimed to determine the transgenerational association of early-life (...) (Hypertension)

6 December

Hypertension https://www.ahajournals.org/

• 11:00
  Hypertension-Mediated Organ Damage: Prevalence, Correlates, and Prognosis in the Community - Ramachandran S. Vasan Rebecca J. Song Vanessa Xanthakis Alexa Beiser Charles DeCarli Gary F. Mitchell Sudha Seshadri Boston University’s and National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, MA (R.S.V., V.X., A.B.). Section of Preventive Medicine and Epidemiology, Department of Medicine (R.S.V., V.X.), Boston University School of Medicine, MA. Department of Neurology (A.B.), Boston University School of Medicine, MA. Department of Epidemiology (R.S.V., R.J.S.), Boston University School of Public Health, Boston, MA. Department of Biostatistics (V.X., A.B.), (...) Hypertension
  Hypertension, Volume 79, Issue 3, Page 505-515, March 1, 2022. Background:Guidelines emphasize screening people with elevated BP for the presence of end-organ damage.Methods:We characterized the prevalence, correlates, and prognosis of hypertension-mediated organ damage (HMOD) in the (...) (Hypertension)
• 11:01
  BBSome: a New Player in Hypertension and Other Cardiovascular Risks - Yuying Zhao Kamal Rahmouni Department of Neuroscience and Pharmacology (Y.Z., K.R.), University of Iowa Carver College of Medicine, Iowa City. Department of Internal Medicine (K.R.), University of Iowa Carver College of Medicine, Iowa City. Fraternal Order of Eagles Diabetes Research Center (K.R.), University of Iowa Carver College of Medicine, Iowa City. and Obesity Research and Educational Initiative (K.R.), University of Iowa Carver College of Medicine, Iowa City. Human Toxicology Graduate Program, University of Iowa Graduate College, Iowa City, IA (Y.Z.). Iowa City VA Health Care (...) Hypertension
  Hypertension, Volume 79, Issue 2, Page 303-313, February 1, 2022. The BBSome is an octameric protein complex involved in Bardet-Biedl syndrome (BBS), a human pleiotropic, autosomal recessive condition. Patients with BBS display various clinical features including obesity, hypertension, and (...) (Hypertension)
• 11:00
  Impaired Sphingosine-1-Phosphate Synthesis Induces Preeclampsia by Deactivating Trophoblastic YAP (Yes-Associated Protein) Through S1PR2 (Sphingosine-1-Phosphate Receptor-2)-Induced Actin Polymerizations - Jiujiang Liao Yangxi Zheng Mingyu Hu Ping Xu Li Lin Xiyao Liu Yue Wu Biao Huang Xuan Ye Sisi Li Ran Duan Huijia Fu Jiayu Huang Li Wen Yong Fu Mark D. Kilby Louise C. Kenny Philip N. Baker Hongbo Qi Chao Tong State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, The First Affiliated Hospital of Chongqing Medical University, China (J.L., Y.Z., M.H., P.X., L.L., X.L., Y.W., B.H., X.Y., S.L., R.D., H.F., J.H., L.W., Y.F., H.Q., C.T.). State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, China (J.L., M.H., P.X., L.L., X.L., Y.W., B.H., X.Y., (...) Hypertension
  Hypertension, Volume 79, Issue 2, Page 399-412, February 1, 2022. Incomplete spiral artery remodeling, caused by impaired extravillous trophoblast invasion, is a fundamental pathogenic process associated with malplacentation and the development of preeclampsia. Nevertheless, the mechanisms (...) (Hypertension)
• 11:00
  Prognostic Value of Changes in Aortic Stiffness for Cardiovascular Outcomes and Mortality in Resistant Hypertension: a Cohort Study - Claudia R.L. Cardoso Gil F. Salles Department of Internal Medicine, University Hospital Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro, Brazil. Hypertension
  Hypertension, Volume 79, Issue 2, Page 447-456, February 1, 2022. The prognostic importance of changes in aortic stiffness for the occurrence of adverse cardiovascular outcomes and mortality has never been investigated in patients with resistant hypertension. We aimed to evaluate it in a (...) (Hypertension)
• 11:00
  Reduced Aircraft Noise Pollution During COVID-19 Lockdown Is Beneficial to Public Cardiovascular Health: a Perspective on the Reduction of Transportation-Associated Pollution - Omar Hahad Andreas Daiber Thomas Münzel Department of Cardiology, Cardiology I, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (O.H., A.D., T.M.). German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany (O.H., A.D., T.M.). Leibniz Institute for Resilience Research (LIR), Mainz, Germany (O.H.). Hypertension
  Hypertension, Volume 79, Issue 2, Page 335-337, February 1, 2022. (Hypertension)

3 December

Hypertension https://www.ahajournals.org/

• 11:00
  Mechanisms of Flow-Mediated Dilation of Pial Collaterals and the Effect of Hypertension - Zhaojin Li Marilyn J. Cipolla Department of Neurological Sciences (Z.L., M.J.C.), University of Vermont Robert Larner College of Medicine, Burlington. Department of Obstetrics, Gynecology, and Reproductive Sciences (M.J.C.), University of Vermont Robert Larner College of Medicine, Burlington. Department of Pharmacology (M.J.C.), University of Vermont Robert Larner College of Medicine, Burlington. Hypertension
  Hypertension, Volume 79, Issue 2, Page 457-467, February 1, 2022. Leptomeningeal anastomoses are small distal anastomotic vessels also known as pial collaterals in the brain. These vessels redirect blood flow during an occlusion and are important for stroke treatment and outcome. Pial (...) (Hypertension)

2 December

Hypertension https://www.ahajournals.org/

• 11:01
  Increased Backward Wave Pressures Rather than Flow Explain Age-Dependent Heart Rate Effects on Central, But not Peripheral Arterial Pressure - Nonhlanhla Mthembu Gavin R. Norton Vernice R. Peterson Ravi Naran Suraj M. Yusuf Grace Tade Hamza Bello Adamu Bamaiyi Carlos D. Libhaber Patrick Dessein Ferande Peters Pinhas Sareli Angela J. Woodiwiss Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Hypertension
  Hypertension, Volume 79, Issue 2, Page 435-446, February 1, 2022. Through both backward (Pb) and forward (Pf) wave effects, a lower heart rate (HR) associates with increased central (PPc), beyond brachial pulse pressure (PP). However, the relative contribution to Pf of aortic flow (Q) versus (...) (Hypertension)
• 11:00
  Nalfurafine, a G-Protein–Biased KOR (Kappa Opioid Receptor) Agonist, Enhances the Diuretic Response and Limits Electrolyte Losses to Standard-of-Care Diuretics - Jacob K. Meariman Jane C. Sutphen Juan Gao Daniel R. Kapusta Department of Pharmacology and Experimental Therapeutics (J.K.M., J.C.S., J.G., D.R.K.), Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA. Cardiovascular Center of Excellence (D.R.K.), Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA. Hypertension
  Hypertension, Volume 79, Issue 2, Page 379-390, February 1, 2022. Nalfurafine is a G-protein–biased KOR (kappa opioid receptor) agonist that produces analgesia and lacks central nervous system adverse effects. Here, we examined the cardiovascular and renal responses to intravenous and oral (...) (Hypertension)
• 11:00
  Home Blood Pressure Monitoring for Hypertension Diagnosis by Current Recommendations: A Long Way to Go - Kelsey B. Bryant Matthew B. Green Daichi Shimbo Joseph E. Schwartz Ian M. Kronish Yiyi Zhang James P. Sheppard Richard J. McManus Andrew E. Moran Brandon K. Bellows Division of General Medicine, Icahn School of Medicine at Mount Sinai, NY (K.B.B.). Division of General Medicine, Columbia Irving Medical Center, NY (M.B.G., D.S., J.E.S., I.M.K., Y.Z., A.E.M., B.K.B.). Stony Brook University, NY (J.E.S.). University of Oxford, United Kingdom (J.P.S., (...) Hypertension
  Hypertension, Volume 79, Issue 2, Page e15-e17, February 1, 2022. (Hypertension)
• 11:00
  Novel CUL3 Variant Causing Familial Hyperkalemic Hypertension Impairs Regulation and Function of Ubiquitin Ligase Activity - Harish E. Chatrathi Jason C. Collins Lynne A. Wolfe Thomas C. Markello David R. Adams William A. Gahl Achim Werner Prashant Sharma NIH Undiagnosed Diseases Program, Common Fund, Office of the Director (H.E.C., L.A.W., T.C.M., D.R.A., W.A.G., P.S.), National Institutes of Health, Bethesda, MD Stem Cell Biochemistry Unit, National Institute of Dental and Craniofacial Research (J.C.C., A.W.), National Institutes of Health, Bethesda, MD Medical Genetics Branch, National Human Genome Research Institute (T.C.M., D.R.A., W.A.G.), National Institutes of Health, Bethesda, (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 60-75, January 1, 2022. Familial hyperkalemic hypertension is caused by pathogenic variants in genes of the CUL3 (cullin-3)-KLHL3 (kelch-like-family-member-3)-WNK (with no-lysine [K] kinase) pathway, manifesting clinically as hyperkalemia, metabolic (...) (Hypertension)

30 November

Hypertension https://www.ahajournals.org/

• 11:00
  Dysregulation of ACE (Angiotensin-Converting Enzyme)-2 and Renin-Angiotensin Peptides in SARS-CoV-2 Mediated Mortality and End-Organ Injuries - Kaiming Wang Mahmoud Gheblawi Anish Nikhanj Matt Munan Erika MacIntyre Conar O’Neil Marko Poglitsch Daniele Colombo Franca Del Nonno Zamaneh Kassiri Wendy Sligl Gavin Y. Oudit Division of Cardiology, Department of Medicine (K.W., A.N., G.Y.O.), University of Alberta, Edmonton, Canada. Mazankowski Alberta Heart Institute (K.W., M.G., A.N., G.Y.O.), University of Alberta, Edmonton, Canada. Department of Physiology (M.G., Z.K., G.Y.O.), University of Alberta, Edmonton, Canada. Department of Critical Care Medicine (M.M., E.M., W.S.), University of Alberta, Edmonton, Canada. Division of (...) Hypertension
  Hypertension, Volume 79, Issue 2, Page 365-378, February 1, 2022. ACE (angiotensin-converting enzyme)-2 as the target for SARS-CoV-2 also negatively regulates the renin-angiotensin system. Pathological activation of ADAM17 (A disintegrin and metalloproteinase-17) may potentiate inflammation and (...) (Hypertension)

24 November

Hypertension https://www.ahajournals.org/

• 11:00
  Clinical Implications Hypertension
  Hypertension, Volume 79, Issue 1, Page 3-3, January 1, 2022. (Hypertension)

23 November

Hypertension https://www.ahajournals.org/

• 11:00
  Activation of the Organum Vasculosum of the Lamina Terminalis Produces a Sympathetically Mediated Hypertension - Sean D. Stocker Megan M. Wenner William B. Farquhar Kirsteen N. Browning Department of Neurobiology, University of Pittsburgh School of Medicine (S.D.S.). Department of Neural and Behavioral Sciences, Penn State College of Medicine (K.N.B.). Department of Kinesiology and Applied Physiology, University of Delaware (M.M.W., W.B.F.). Hypertension
  Hypertension, Volume 79, Issue 1, Page 139-149, January 1, 2022. Neurons in the organum vasculosum of the lamina terminalis (OVLT) sense extracellular NaCl and angiotensin II concentrations to regulate body fluid homeostasis and arterial blood pressure. Lesion of the anteroventral third (...) (Hypertension)

19 November

Hypertension https://www.ahajournals.org/

• 11:00
  Neutrophil Gelatinase-Associated Lipocalin From Macrophages Plays a Critical Role in Renal Fibrosis Via the CCL5 (Chemokine Ligand 5)-Th2 Cells-IL4 (Interleukin 4) Pathway - Benjamin Bonnard Jaime Ibarrola Ixchel Lima-Posada Amaya Fernández-Celis Manon Durand Marie Genty Natalia Lopez-Andrés Frédéric Jaisser Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, France (B.B., I.L.-P., M.D., M.G., F.J.). Cardiovascular Translational Research, Navarrabiomed (Miguel Servet Foundation), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain (J.I., A.F.-C., N.L.-A.). INSERM, Clinical Investigation Centre 1433, French-Clinical Research Infrastructure Network (F-CRIN) INI-CRCT, Nancy, France (...) Hypertension
  Hypertension, Volume 79, Issue 2, Page 352-364, February 1, 2022. NGAL (neutrophil gelatinase-associated lipocalin; or lipocalin 2, Lcn2) is a novel mineralocorticoid target in the cardiovascular system. We showed that Lcn2 gene invalidation protects against proteinuria and renal injury upon (...) (Hypertension)

17 November

Hypertension https://www.ahajournals.org/

• 11:01
  Self-Reported Antihypertensive Medication Class and Temporal Relationship to Treatment Guidelines - Brent M. Egan Jianing Yang Michael K. Rakotz Susan E. Sutherland Kenneth A. Jamerson Jackson T. Wright Keith C. Ferdinand Gregory D. Wozniak Improving Health Outcomes, American Medical Association, Greenville, SC (B.M.E., S.E.S.). Improving Health Outcomes, American Medical Association, Chicago, IL (J.Y., M.K.R., G.D.W.). Department of Medicine, University of Michigan Medical Center, Ann Arbor (K.A.J.). Department of Medicine, Case Western Reserve, Cleveland, OH (J.T.W.). Department of Medicine, Tulane University School of Medicine, New Orleans, LA (...) Hypertension
  Hypertension, Volume 79, Issue 2, Page 338-348, February 1, 2022. The greater antihypertensive responses to initial therapy with calcium channel blockers (CCBs) or thiazide-type diuretics than renin-angiotensin system blockers as initial therapy in non-Hispanic Black (NHB) adults was recognized (...) (Hypertension)
• 11:00
  Myocardial Mechanics in Hypertensive Disorders of Pregnancy: a Systematic Review and Meta-Analysis - Jamie M. O’Driscoll Veronica Giorgione Jamie J. Edwards Jonathan D. Wiles Rajan Sharma Baskaran Thilaganathan School of Psychology and Life Sciences, Canterbury Christ Church University, Kent (J.M.O., J.J.E., J.D.W.). Department of Cardiology, St George’s Healthcare NHS Trust, London (J.M.O., R.S.). Fetal Medicine Unit, St George’s University Hospitals NHS Foundation Trust, University of London, United Kingdom (V.G., B.T.). Molecular and Clinical Sciences Research Institute, St George’s University of London, United Kingdom (V.G., (...) Hypertension
  Hypertension, Volume 79, Issue 2, Page 391-398, February 1, 2022. Global longitudinal strain (GLS) is becoming routinely used to direct the medical management of various cardiac diseases, but its application in pregnancy is unclear. Our objective was to perform a meta-analysis and pool multiple (...) (Hypertension)
• 11:01
  Cholesterol-Induced Suppression of Endothelial Kir Channels Is a Driver of Impairment of Arteriolar Flow-Induced Vasodilation in Humans - Sang Joon Ahn Ibra S. Fancher Sara T. Granados Natalia F. Do Couto Chueh-Lung Hwang Shane A. Phillips Irena Levitan Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep, College of Medicine (S.J.A., I.S.F., S.T.G., N.F.D.C., I.L.), University of Illinois at Chicago. Department of Physical Therapy, College of Applied Health Science (N.F.D.C., C.-L.H., S.A.P.), University of Illinois at Chicago. Department of Kinesiology and Applied Physiology, College of Health Sciences, University of Delaware (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 126-138, January 1, 2022. Dyslipidemia-induced endothelial dysfunction is an important factor in the progression of cardiovascular disease; however, the underlying mechanisms are unclear. Our recent studies demonstrated that flow-induced vasodilation (FIV) (...) (Hypertension)
• 11:01
  Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health - Geng Wang Laxmi Bhatta Gunn-Helen Moen Liang-Dar Hwang John P. Kemp Tom A. Bond Bjørn Olav Åsvold Ben Brumpton David M. Evans Nicole M. Warrington The University of Queensland Diamantina Institute (G.W., G.-H.M., L.-D.H., J.P.K., T.A.B., D.M.E., N.M.W.), The University of Queensland, Brisbane, Australia. Institute of Molecular Bioscience (L.-D.H., J.P.K., D.M.E., N.M.W.), The University of Queensland, Brisbane, Australia. K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway (L.B., (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 170-177, January 1, 2022. Observational epidemiological studies have reported that higher maternal blood pressure (BP) during pregnancy is associated with increased future risk of offspring cardiometabolic disease. However, it is unclear whether this (...) (Hypertension)
• 11:01
  Is the KDIGO Systolic Blood Pressure Target - Indranil Dasgupta Carmine Zoccali Department of Renal Medicine, University Hospitals Birmingham NHS Foundation Trust and University of Warwick, United Kingdom (I.D.). Renal Research Institute, New York, NY (C.Z.). IPNET c/o Nefrologia e CNR, Grande Ospedale Metropolitano, Reggio Cal, Italy (C.Z.). Hypertension
  Hypertension, Volume 79, Issue 1, Page 4-11, January 1, 2022. Meticulous management of hypertension is important in chronic kidney disease (CKD) to reduce the risk of cardiovascular disease, mortality, and progression of CKD. The recently published Kidney Disease Improving Global Outcomes (...) (Hypertension)
• 11:00
  Feasibility of Imaging-Guided Adrenalectomy in Young Patients With Primary Aldosteronism - Gian Paolo Rossi Filippo Crimì Giacomo Rossitto Laurence Amar Michel Azizi Anna Riester Martin Reincke Christoph Degenhart Jiri Widimsky Mitsuhide Naruse Jaap Deinum Leo Schultze Kool Tomaz Kocjan Aurelio Negro Ermanno Rossi Gregory Kline Akiyo Tanabe Fumitoshi Satoh Lars Christian Rump Oliver Vonend Holger S. Willenberg Peter J. Fuller Jun Yang Nicholas Yong Nian Chee Steven B. Magill Zulfiya Shafigullina Marcus Quinkler Anna Oliveras Vin Cent Wu Zuzana Kratka Giulio Barbiero Michele Battistel Teresa Maria Seccia Department of Medicine-DIMED, International PhD Program in Arterial (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 187-195, January 1, 2022. Many of the patients with primary aldosteronism (PA) are denied curative adrenalectomy because of limited availability or failure of adrenal vein sampling. It has been suggested that adrenal vein sampling can be omitted in young (...) (Hypertension)
• 11:00
  Effects of Arterial Stiffness and Carotid Intima-Media Thickness Progression on the Risk of Overweight/Obesity and Elevated Blood Pressure/Hypertension: a Cross-Lagged Cohort Study - Andrew O. Agbaje Alan R. Barker Tomi-Pekka Tuomainen Institute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (A.O.A., T.-P.T.). Children’s Health and Exercise Research Centre, Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, United Kingdom (A.R.B.). Hypertension
  Hypertension, Volume 79, Issue 1, Page 159-169, January 1, 2022. We examined the temporal longitudinal associations of carotid-femoral pulse wave velocity (cfPWV), a measure of arterial stiffness, and carotid intima-media thickness (cIMT) with the risk of overweight/obesity and elevated blood (...) (Hypertension)
• 11:00
  Carotid Plaques From Symptomatic Patients With Mild Stenosis Is Associated With Intraplaque Hemorrhage - Valentina Nardi John Benson Melanie C. Bois Luca Saba Anthony S. Larson Ilke Özcan Ali Ahmad David W. Morse Fredric B. Meyer Waleed Brinjikji Giuseppe Lanzino Lilach O. Lerman Luis E. Savastano Amir Lerman Department of Cardiovascular Medicine (V.N., I.Ö., A.A., D.W.M., A.L.), Mayo Clinic, Rochester, MN. Department of Radiology (J.C.B., A.S.L., W.B.), Mayo Clinic, Rochester, MN. Department of Laboratory Medicine and Pathology (M.C.B.), Mayo Clinic, Rochester, MN. Department of Neurologic Surgery (F.B.M., G.L., L.E.S.), Mayo Clinic, Rochester, MN. Department of Nephrology and Hypertension (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 271-282, January 1, 2022. Carotid plaque vulnerability features beyond the degree of stenosis may play a key role in the pathogenesis and recurrence of ischemic cerebrovascular events.This study sought to compare intraplaque hemorrhage (IPH) as a marker of (...) (Hypertension)
• 11:00
  High Lead Exposure Associated With Higher Blood Pressure in Haiti: a Warning Sign for Low-Income Countries - Lily D. Yan Vanessa Rouzier Jean Lookens Pierre Myung Hee Lee Paul Muntner Patrick J. Parsons Alexandra Apollon Stephano St-Preux Rodolphe Malebranche Gerard Pierre Evens Emmanuel Denis Nash Justin Kingery Kathleen F. Walsh Caleigh E. Smith Miranda Metz Olga Tymejczyk Marie Deschamps Jean W. Pape Daniel W. Fitzgerald Margaret L. McNairy Division of General Internal Medicine, Department of Medicine (L.D.Y., J.K., K.F.W., M.L.M.), Weill Cornell Medicine, New York, New York. Center for Global Health, Department of Medicine (L.D.Y., V.R., M.H.L., J.K., K.F.W., C.E.S., M.M., J.W.P., D.W.F., (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 283-290, January 1, 2022. Cardiovascular disease is the leading cause of death in lower-income countries including Haiti. Environmental lead exposure is associated with high blood pressure and cardiovascular mortality in high-income countries but has not (...) (Hypertension)
• 11:00
  Macrophage 12(S)-HETE Enhances Angiotensin II–Induced Contraction by a BLT2 (Leukotriene B4 Type-2 Receptor) and TP (Thromboxane Receptor)-Mediated Mechanism in Murine Arteries - Tamas Kriska Anja Herrnreiter Sandra L. Pfister Adeniyi Adebesin John R. Falck William B. Campbell Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee (T.K., A.H., S.L.P., W.B.C.). Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas (A.A., J.R.F.). Hypertension
  Hypertension, Volume 79, Issue 1, Page 104-114, January 1, 2022. 12/15-LO (12/15-lipoxygenase), encoded byAlox15gene, metabolizes arachidonic acid to 12(S)-HETE (12-hydroxyeicosatetraenoic acid). Macrophages are the major source of 12/15-LO among immune cells, and 12/15-LO plays a crucial role (...) (Hypertension)
• 11:00
  Multiple Social Vulnerabilities to Health Disparities and Hypertension and Death in the REGARDS Study - Jordan B. King Laura C. Pinheiro Joanna Bryan Ringel Adam P. Bress Daichi Shimbo Paul Muntner Kristi Reynolds Mary Cushman George Howard Jennifer J. Manly Monika M. Safford Department of Population Health Sciences, School of Medicine, University of Utah (J.B.K., A.P.B.). Institute for Health Research, Kaiser Permanente Colorado (J.B.K.). Department of Medicine, Weill Medical College of Cornell University (L.C.P., J.B.R., M.M.S.). Department of Medicine (D.S.), Columbia University Vagelos College of Physicians and Surgeons. Department of Neurology (J.J.M.), Columbia University Vagelos (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 196-206, January 1, 2022. Social vulnerabilities increase the risk of developing hypertension and lower life expectancy, but the effect of an individual’s overall vulnerability burden is unknown. Our objective was to determine the association of social (...) (Hypertension)
• 11:00
  Increased Collagen Turnover Is a Feature of Fibromuscular Dysplasia and Associated With Hypertrophic Radial Remodeling: A Pilot, Urine Proteomic Study - Agnieszka Latosinska Rosa Maria Bruno Marco Pappaccogli Alessandra Bacca Christophe Beauloye Pierre Boutouyrie Hakim Khettab Jan A Staessen Stefano Taddei Laurent Toubiana Miikka Vikkula Harald Mischak Alexandre Persu Mosaiques Diagnostics GmbH, Hannover, Germany (A.L., H.M.). INSERM U970 Team 7, Paris Cardiovascular Research Centre – PARCC and Université de Paris, France (R.M.B., P.B.). Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Turin, Italy (M.P.). Division of Cardiology, Cliniques Universitaires Saint-Luc, Université catholique de (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 93-103, January 1, 2022. Fibromuscular dysplasia (FMD), a nonatherosclerotic, noninflammatory disease of medium-sized arteries, is an underdiagnosed disease. We investigated the urinary proteome and developed a classifier for discrimination of FMD from (...) (Hypertension)

15 November

Hypertension https://www.ahajournals.org/

• 11:00
  Blood Pressure Levels and Risks of Dementia: a Nationwide Study of 4.5 Million People - Chan Joo Lee Ji-Yeon Lee Kyungdo Han Da Hye Kim Hanna Cho Kwang Joon Kim Eun Seok Kang Bong-Soo Cha Yong-ho Lee Sungha Park Cardiology Division, Severance Cardiovascular Hospital and Cardiovascular Research Institute (C.J.L., S.P.), Yonsei University College of Medicine, Seoul, Republic of Korea. Division of Endocrinology and Metabolism (J.-Y.L., E.S.K., B.-S.C., Y.-h.L.), Yonsei University College of Medicine, Seoul, Republic of Korea. Division of Geriatrics (K.J.K.), Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. Department of (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 218-229, January 1, 2022. There are inconsistent results on the impacts of controlling blood pressure (BP) on the risk of dementia. We investigated the association between BP and risk of dementia subtypes by antihypertensive treatment and comorbidities. (...) (Hypertension)
• 11:00
  National Trends in Racial and Ethnic Disparities in Antihypertensive Medication Use and Blood Pressure Control Among Adults With Hypertension, 2011–2018 - Yuan Lu Yuntian Liu Lovedeep Singh Dhingra Daisy Massey César Caraballo Shiwani Mahajan Erica S. Spatz Oyere Onuma Jeph Herrin Harlan M. Krumholz Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT (Y. Lu, Y. Liu, L.S.D., D.M., C.C., S.M., E.S.S., O.O., H.M.K.). Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT (Y. Lu, Y. Liu, L.S.D., D.M., C.C., S.M., E.S.S., O.O., J.H., H.M.K.). Department of Health Policy and Management, Yale School of Public Health, New Haven, CT (H.M.K.). Department of (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 207-217, January 1, 2022. Poor hypertension awareness and underuse of guideline-recommended medications are critical factors contributing to poor hypertension control. Using data from 8095 hypertensive people aged ?18 years from the National Health and (...) (Hypertension)
• 11:00
  Twenty-Four–Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals - Thomas Weber Athanase D. Protogerou Mohsen Agharazii Antonis Argyris Sola Aoun Bahous Jose R. Banegas Ronald K. Binder Jacques Blacher Andréa Araujo Brandao Juan J. Cruz Kathrin Danninger Cristina Giannatasio Auxiliadora Graciani Bernhard Hametner Piotr Jankowski Yan Li Alessandro Maloberti Christopher C. Mayer Barry J. McDonnell Carmel M. McEniery Marco Antonio Mota Gomes Annelise Machado Gomes Maria Lorenza Muiesan Janos Nemcsik Anna Paini Enrique Rodilla Aletta E. Schutte Petros P. Sfikakis Dimitrios Terentes-Printzios Alexandre Vallée Charalambos Vlachopoulos Lisa Ware Ian Wilkinson (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 251-260, January 1, 2022. Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with (...) (Hypertension)
• 11:00
  Carotid Artery Stiffening With Aging: Structural Versus Load-Dependent Mechanisms in MESA (the Multi-Ethnic Study of Atherosclerosis) - Ryan J. Pewowaruk Yacob Tedla Claudia E. Korcarz Matthew C. Tattersall James H. Stein Naomi C. Chesler Adam D. Gepner Department of Medicine, Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI (R.J.P., C.E.K., M.C.T., J.H.S., A.D.G.). Department of Medicine, Division of Epidemiology, Vanderbilt University, Nashville, TN (Y.T.). University of California Irvine, Edwards Lifesciences Center for Advance Cardiovascular Technology, Department of Biomedical Engineering, Irvine, CA (N.C.C.). Department of Medicine, Division of (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 150-158, January 1, 2022. Elastic arteries stiffen via 2 main mechanisms: (1) load-dependent stiffening from higher blood pressure and (2) structural stiffening due to changes in the vessel wall. Differentiating these closely coupled mechanisms is (...) (Hypertension)
• 11:00
  Hypertension Pharmacological Treatment in Adults: A World Health Organization Guideline Executive Summary - Akram Al-Makki Donald DiPette Paul K. Whelton M. Hassan Murad Reem A. Mustafa Shrish Acharya Hind Mamoun Beheiry Beatriz Champagne Kenneth Connell Marie Therese Cooney Nnenna Ezeigwe Thomas Andrew Gaziano Agaba Gidio Patricio Lopez-Jaramillo Unab I. Khan Vindya Kumarapeli Andrew E. Moran Margaret Mswema Silwimba Brian Rayner Apichard Sukonthasan Jing Yu Nizal Saraffzadegan K. Srinath Reddy Taskeen Khan Indiana University Health Arnett, Lafayette (A.A.-M.). Indiana University School of Medicine – West Lafayette (A.A.-M.). College of Pharmacy, Purdue University, West Lafayette, IN (A.A.-M.). (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 293-301, January 1, 2022. Hypertension is a major cause of cardiovascular disease and deaths worldwide especially in low- and middle-income countries. Despite the availability of safe, well-tolerated, and cost-effective blood pressure (BP)-lowering (...) (Hypertension)

10 November

Hypertension https://www.ahajournals.org/

• 08:00
  Common Carotid Artery Flow Parameters Predict the Incidence of Hypertension - Nobuo Sasaki Ryo Maeda Ryoji Ozono Yukiko Nakano Yukihito Higashi Health Management and Promotion Center, Hiroshima Atomic Bomb Casualty Council, Japan (N.S., R.M.). Department of General Medicine (R.O.), Hiroshima University Graduate School of Biomedical and Health Sciences, Japan. Department of Cardiovascular Medicine (Y.N.), Hiroshima University Graduate School of Biomedical and Health Sciences, Japan. Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine (Y.H.), Hiroshima University Graduate School of Biomedical and Health (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1711-1718, December 1, 2021. (Hypertension)
• 08:00
  Genetic Predictors of Salt Sensitivity of Blood Pressure: The Additive Impact of 2 Hits in the Same Biological Pathway - Andrea V. Haas Li En Yee Yan E. Yuan Yin H. Wong Paul N. Hopkins Xavier Jeunemaitre Jessica Lasky-Su Jonathan S. Williams Gail K. Adler Gordon H. Williams Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (A.V.H., Y.E.Y., J.S.W., G.K.A., G.H.W.). Cell and Molecular Biology Laboratory, Department of Cellular Biology and Pharmacology, Faculty of Medicine and Health Sciences, UCSI University, Cheras, Kuala Lumpur, Malaysia (L.E.Y., Y.H.W.). Professor Emeritus, Department of Internal Medicine, University of Utah School of (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1809-1817, December 1, 2021. (Hypertension)
• 08:00
  White-Coat Hypertension: Pathophysiological and Clinical Aspects: Excellence Award for Hypertension Research 2020 - Giuseppe Mancia Rita Facchetti Michele Bombelli Cesare Cuspidi Guido Grassi University of Milano-Bicocca (G.M.), University of Milano-Bicocca, Milan, Italy. Clinica Medica, Department of Medicine and Surgery (R.F., M.B., C.C., G.G.), University of Milano-Bicocca, Milan, Italy. Hypertension
  Hypertension, Volume 78, Issue 6, Page 1677-1688, December 1, 2021. Few issues of modern cardiovascular medicine have been as controversial as the relationship between white-coat hypertension (WCH), that is, a common condition in which office blood pressure is elevated while out-of-office blood (...) (Hypertension)
• 08:00
  Emerging Insights Into Chronic Renal Disease Pathogenesis in Hypertension From Human and Animal Genomic Studies - Isha S. Dhande Michael C. Braun Peter A. Doris Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas HSC, Houston (I.S.D., P.A.D.) Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston (M.C.B.). Hypertension
  Hypertension, Volume 78, Issue 6, Page 1689-1700, December 1, 2021. The pathogenic links between elevated blood pressure and chronic kidney disease remain obscure. This article examines progress in population genetics and in animal models of hypertension and chronic kidney disease. It also (...) (Hypertension)
• 08:00
  SPRINT Revisited: Updated Results and Implications - Jackson T. Wright Paul K. Whelton Karen C. Johnson Joni K. Snyder David M. Reboussin William C. Cushman Jeff D. Williamson Nicholas M. Pajewski Alfred K. Cheung Cora E. Lewis Suzanne Oparil Michael V. Rocco Srinivasan Beddhu Lawrence J. Fine Jeffrey A. Cutler Walter T. Ambrosius Mahboob Rahman Carolyn H. Still Zhengyi Chen Curtis Tatsuoka From the Division of Nephrology and Hypertension, University Hospitals Cleveland Medical Center (J.T.W., M.R.), Case Western Reserve University, Cleveland, OH Frances Payne Bolton School of Nursing (C.H.S.), Case Western Reserve University, Cleveland, OH (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1701-1710, December 1, 2021. The SPRINT (Systolic Blood Pressure Intervention Trial) results have influenced clinical practice but have also generated discussion regarding the validity, generalizability, and importance of the findings. Following the SPRINT (...) (Hypertension)
• 08:00
  Home Blood Pressure Telemonitoring With Remote Hypertension Management in a Rural and Low-Income Population - Donald Clark Julia Woods Yunxi Zhang Saurabh Chandra Richard L. Summers Daniel W. Jones University of Mississippi Medical Center, Jackson. Hypertension
  Hypertension, Volume 78, Issue 6, Page 1927-1929, December 1, 2021. (Hypertension)
• 08:00
  Correction to: Reduction in Regulatory T Cells in Early Pregnancy Causes Uterine Artery Dysfunction in Mice Hypertension
  Hypertension, Volume 78, Issue 6, Page e52-e52, December 1, 2021. (Hypertension)
• 08:00
  Hypertension Update: A Reflection of the Past Decade - Anna F. Dominiczak Trudie J. Meyer University of Glasgow. Hypertension
  Hypertension, Volume 78, Issue 6, Page 1670-1673, December 1, 2021. (Hypertension)
• 08:00
  Editorial commentary: Racial and Ethnic Disparities in Hypertension Prevalence, Awareness, Treatment, and Control in the United States, 2013 to 2018 - Brent M. Egan Department of Medicine, University of South Carolina School of Medicine, Greenville, SC. American Medical Association, Improving Health Outcomes, Greenville, SC. Hypertension
  Hypertension, Volume 78, Issue 6, Page 1727-1729, December 1, 2021. (Hypertension)
• 08:00
  Sleepless in Seattle: Sleep Deprivation and Fragmentation Impair Endothelial Function and Fibrinolysis in Hypertension - Thomas Münzel Omar Hahad Andreas Daiber Department for Cardiology 1, University Medical Center Mainz, Germany. German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany. Hypertension
  Hypertension, Volume 78, Issue 6, Page 1841-1843, December 1, 2021. (Hypertension)
• 08:00
  Novel ANP (Atrial Natriuretic Peptide)-Based Therapy for Hypertension: The Promising Role of a Disease Mechanism Targeted Approach - Massimo Volpe Giovanna Gallo Speranza Rubattu Cardiology Unit, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Sant’Andrea Hospital, Rome, Italy (M.V., G.G., S.R.). IRCCS Neuromed, Pozzilli (IS), Italy (S.R.). Hypertension
  Hypertension, Volume 78, Issue 6, Page 1868-1870, December 1, 2021. (Hypertension)
• 08:00
  Insights Into the Role of Tetrahydrobiopterin Deficiency in the Pathogenesis of Gestational Hypertension - Vincent Dupont S. Ananth Karumanchi Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA. Hypertension
  Hypertension, Volume 78, Issue 6, Page 1885-1887, December 1, 2021. (Hypertension)
• 08:00
  Clinical Implications Hypertension
  Hypertension, Volume 78, Issue 6, Page 1669-1669, December 1, 2021. (Hypertension)

5 November

Hypertension https://www.ahajournals.org/

• 11:28
  Renal Denervation in Combination With Angiotensin Receptor Blockade Prolongs Blood Pressure Trough During Hemorrhage - Reetu R. Singh Zoe McArdle Lindsea C. Booth Clive N. May Geoff A. Head Karen M. Moritz Markus P. Schlaich Kate M. Denton Cardiovascular Program, Monash Biomedicine Discovery Institute and Department of Physiology, Monash University, Melbourne, Australia (R.R.S., Z.M., K.M.D.). The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia (L.C.B., C.N.M.). Baker IDI Heart and Diabetes Institute, Melbourne, Australia (G.A.H., M.P.S.). School of Biomedical Sciences, The University of Queensland, Brisbane, Australia (K.M.M.). School of Medicine and (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 261-270, January 1, 2022. Majority of patients with hypertension and chronic kidney disease (CKD) undergoing renal denervation (RDN) are maintained on antihypertensive medication. However, RDN may impair compensatory responses to hypotension induced by (...) (Hypertension)
• 11:28
  Clinical Significance of Mean and Pulse Pressure in Patients With Heart Failure With Preserved Ejection Fraction - Fang-Fei Wei Yuzhong Wu Ruicong Xue Xiao Liu Xin He Bin Dong Zhe Zhen Xuwei Chen Weihao Liang Jingjing Zhao Jiangui He Yugang Dong Jan A. Staessen Chen Liu Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China (F.-F.W., Y.W., R.X., X.H., B.D., Z.Z., X.C., W.L., J.Z., J.H., Y.D., C.L.). NHC Key Laboratory of Assisted Circulation, Sun Yat-Sen University, Guangzhou, China (F.-F.W., Y.W., R.X., X.H., B.D., Z.Z., X.C., W.L., J.Z., J.H., Y.D., C.L.). Department of Cardiology, the Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 241-250, January 1, 2022. It remains debated whether pulse pressure is associated with left ventricular traits and adverse outcomes over and beyond mean arterial pressure (MAP) in patients with heart failure (HF) with preserved ejection fraction. We (...) (Hypertension)
• 11:28
  Angiotensin II Type 1 Receptor Tachyphylaxis Is Defined by Agonist Residence Time - Diego A. Duarte Lucas T. Parreiras-e-Silva Eduardo B. Oliveira Michel Bouvier Claudio M. Costa-Neto Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil (D.A.D., L.T.P.-e.-S., E.B.O., C.M.C.-N.). Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, QC, Canada (M.B.). Hypertension
  Hypertension, Volume 79, Issue 1, Page 115-125, January 1, 2022. Several GPCRs (G-protein–coupled receptors) have been reported to exhibit tachyphylaxis, which is an acute loss of functional receptor response after repeated stimuli with an agonist. GPCRs are important clinical targets for a wide (...) (Hypertension)
• 11:28
  Nonadherence in Hypertension: How to Develop and Implement Chemical Adherence Testing - Dan Lane Alexander Lawson Angela Burns Michel Azizi Michel Burnier Donald J.L. Jones Benjamin Kably Kamlesh Khunti Reinhold Kreutz Prashanth Patel Alexandre Persu Wilko Spiering Stefan W. Toennes Maciej Tomaszewski Bryan Williams Pankaj Gupta Indranil Dasgupta The Department of Chemical Pathology and Metabolic Diseases, Level 4, Sandringham Building, Leicester Royal Infirmary, United Kingdom (D.L., P.P., P.G.). Leicester Diabetes Centre, University of Leicester, Leicester General Hospital, Leicester, United Kingdom (D.L., K.K.). Department of Clinical Chemistry, Immunology and Toxicology, (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 12-23, January 1, 2022. Nonadherence to antihypertensive medication is common, especially in those with apparent treatment-resistant hypertension (true treatment-resistant hypertension requires exclusion of nonadherence), and its routine detection is (...) (Hypertension)
• 11:28
  Standardized Autonomic Testing in Patients With Probable Radiation-Induced Afferent Baroreflex Failure - Guillaume Lamotte Elizabeth A. Coon Mariana D. Suarez Paola Sandroni Eduardo Benarroch Jeremy K. Cutsforth-Gregory Michelle L. Mauermann Sarah E. Berini Kamal Shouman David Sletten Brent P. Goodman Phillip A. Low Wolfgang Singer Department of Neurology, Mayo Clinic, Rochester, MN (G.L., E.A.C., M.D.S., P.S., E.B., J.K.C.-G., M.L.M., S.E.B., K.S., D.S., P.A.L., W.S.). Department of Neurology, Mayo Clinic, Scottsdale, AZ (B.P.G.). Hypertension
  Hypertension, Volume 79, Issue 1, Page 50-56, January 1, 2022. Injury of the afferent limb of the baroreflex from neck radiation causes radiation-induced afferent baroreflex failure (R-ABF). Identification and management of R-ABF is challenging. We aimed to investigate the pattern of autonomic (...) (Hypertension)
• 11:28
  Reduced Notch1 Cleavage Promotes the Development of Pulmonary Hypertension - Shumin Wang Guofu Zhu Dongyang Jiang Jordan Rhen Xiankai Li Hao Liu Yuyan Lyu Patrick Tsai Yara Rose Tiffany Nguyen R. James White Gloria S. Pryhuber Thomas J. Mariani Chen Li Amy Mohan Yawei Xu Jinjiang Pang Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, NY (S.W., J.R., Y.R., T.N., R.J.W., A.M., J.P.). Department of Cardiology, Pan-Vascular Research Institute, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, China (G.Z., D.J., X.L., H.L., Y.L., Y.X.). Department of Neurobiology, Physiology (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 79-92, January 1, 2022. Clinical trials of Dll4 (Delta-like 4) neutralizing antibodies (Dll4nAbs) in cancer patients are ongoing. Surprisingly, pulmonary hypertension (PH) occurs in 14% to 18% of patients treated with Dll4nAbs, but the mechanisms have not (...) (Hypertension)

1 November

Hypertension https://www.ahajournals.org/

• 10:00
  Tribute to Lewis Landsberg: A Giant of Academic Medicine - Daniel Batlle Division of Nephrology/Hypertension, Department of Medicine Northwestern University, Feinberg School of Medicine Chicago, IL. Hypertension
  Hypertension, Volume 79, Issue 1, Page 291-292, January 1, 2022. (Hypertension)
• 10:01
  Racial and Ethnic Differences in Blood Pressure Among US Adults, 1999–2018 - Shakia T. Hardy Ligong Chen Andrea L. Cherrington Nathalie Moise Byron C. Jaeger Kathryn Foti Swati Sakhuja Gregory Wozniak Marwah Abdalla Paul Muntner Department of Epidemiology (S.T.H., L.C., S.S., P.M.), University of Alabama at Birmingham. Department of Medicine (A.L.C.), University of Alabama at Birmingham. Department of Biostatistics (B.C.J.), University of Alabama at Birmingham. Department of Medicine, Columbia University, New York, NY (N.M., M.A.). Department of Epidemiology, Johns Hopkins University, Baltimore, MD (K.F.). American Medical Association, Chicago, IL (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1730-1741, December 1, 2021. (Hypertension)
• 10:01
  Theodore Allen Kotchen, MD: June 27, 1938–July 6, 2021 - Allen W. Cowley Srividya Kidambi Mingyu Liang Clarence Grim Pavel Hamet Hypertension
  Hypertension, Volume 78, Issue 6, Page 1674-1676, December 1, 2021. (Hypertension)
• 10:01
  Cardiovascular Prognosis in Drug-Resistant Hypertension Stratified by 24-Hour Ambulatory Blood Pressure: The JAMP Study - Kazuomi Kario Satoshi Hoshide Keisuke Narita Yukie Okawara Hiroshi Kanegae Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan (K.K., S.H., K.N., Y.O., H.K.). Genki Plaza Medical Center for Health Care, Tokyo, Japan (H.K.)., Investigators’ network Kenji Aoki Hajime Kihara Toshiro Koga Tomoaki Nakata Kenji Oku Yasufumi Matsuoka Hiroaki Omori Masafumi Nishizawa Yasuo Tanno Yoko Fukase Koki Omi Jun Takahashi Hiroyuki Mizuno Michiya Saito Junichi Yatabe Kazuo Eguchi Kiyoshi Iwashita Maki Kumada Gaku Oki Gaku Oki Tomoyuki (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1781-1790, December 1, 2021. (Hypertension)
• 10:01
  Locomotor Muscle Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction - Michael A. Francisco Joshua F. Lee Zachary Barrett-O’Keefe H. Jonathan Groot Stephen M. Ratchford Kanokwan Bunsawat Jeremy K. Alpenglow John J. Ryan Jose N. Nativi Russell S. Richardson D. Walter Wray Department of Internal Medicine (M.A.F., J.F.L., K.B., J.J.R., J.N.N., R.S.R., D.W.W.), University of Utah, Salt Lake City. Department of Nutrition and Integrative Physiology (Z.B.-O., H.J.G., R.S.R., D.W.W.), University of Utah, Salt Lake City. Geriatric Research, Education, and Clinical Center, VA Medical Center, Salt Lake City, UT (M.A.F., J.F.L., Z.B.-O., H.J.G., S.M.R., J.K.A., R.S.R., (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1750-1759, December 1, 2021. (Hypertension)
• 10:00
  Noninvasive Biomarkers for Cardiovascular Dysfunction Programmed in Male Offspring of Adverse Pregnancy - Rama Lakshman Ana-Mishel Spiroski Lauren B. McIver Michael P. Murphy Dino A. Giussani Department of Physiology, Development and Neuroscience (R.L., A.-M.S., L.B.M., D.A.G.), University of Cambridge, United Kingdom. MRC Mitochondria Biology Unit (M.P.M.), University of Cambridge, United Kingdom. Cambridge BHF Centre of Research Excellence (A.-M.S., M.P.M., D.A.G.), University of Cambridge, United Kingdom. Department of Medicine (M.P.M., D.A.G.), University of Cambridge, United Kingdom. Cambridge Strategic Research Initiative in Reproduction, United Kingdom (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1818-1828, December 1, 2021. (Hypertension)
• 10:00
  Elastin-Like Polypeptide: VEGF-B Fusion Protein for Treatment of Preeclampsia - Jamarius P. Waller John Aaron Howell Hali Peterson Eric M. George Gene L. Bidwell From the Department of Pharmacology and Toxicology (J.P.W., G.L.B.), University of Mississippi Medical Center, Jackson, MS. Department of Neurology (J.A.H., G.L.B.), University of Mississippi Medical Center, Jackson, MS. Department of Medicine (H.P.), University of Mississippi Medical Center, Jackson, MS. Department of Physiology (E.M.G.), University of Mississippi Medical Center, Jackson, MS. Department of Cell and Molecular Biology (E.M.G., G.L.B.), University of Mississippi Medical Center, Jackson, (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1888-1901, December 1, 2021. (Hypertension)
• 10:00
  Risk-Based Intensive Blood Pressure Lowering and Prevention of Heart Failure: A SPRINT Post Hoc Analysis - Rebecca J. Molsberry Leah Rethy Michael C. Wang Rupal C. Mehta Donald M. Lloyd-Jones Hongyan Ning Cora E. Lewis Clyde W. Yancy Sanjiv J. Shah Sadiya S. Khan Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center, School of Public Health, Houston, TX (R.J.M.). Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (L.R.). Department of Preventive Medicine (D.L.J., H.N., S.S.K.), Northwestern University Feinberg School of Medicine, Chicago, IL. Division of Cardiology, Department of (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1742-1749, December 1, 2021. (Hypertension)
• 10:00
  Serum Magnesium, Blood Pressure, and Risk of Hypertension and Chronic Kidney Disease Progression in the CRIC Study - Simon Correa Xavier E. Guerra-Torres Sushrut S. Waikar Finnian R. Mc Causland Department of Internal Medicine, Yale School of Medicine, New Haven, CT (S.C.). Yale New Haven Hospital, CT (S.C.). Division of Renal Medicine, Brigham and Women’s Hospital. Boston, MA (S.C., F.R.M.C.). Harvard Medical School, Boston, MA (S.C., F.R.M.C.). Nephrology Section, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain (X.E.G.-T.). Section of Nephrology, Department of Medicine, Boston University School of Medicine and Boston Medical Center, MA (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1771-1780, December 1, 2021. (Hypertension)
• 10:00
  Acute Aerobic Exercise Induces Short-Term Reductions in Ambulatory Blood Pressure in Patients With Hypertension: A Systematic Review and Meta-Analysis - Gonzalo Saco-Ledo Pedro L. Valenzuela Miguel Ramírez-Jiménez Javier S. Morales Adrián Castillo-García James A. Blumenthal Luis M. Ruilope Alejandro Lucia Bioenergy and Motion Analysis Laboratory, National Research Center on Human Evolution (CENIEH), Burgos, Spain (G.S.-L.). Faculty of Sport Sciences, European University of Madrid, Spain (P.L.V., L.M.R., A.L.). Exercise Physiology Laboratory, University of Castilla-La Mancha, Toledo, Spain (M.R.-J.). Faculty of Social Sciences and Law, Catholic University of Avila, Avila, Spain (M.R.-J.). MOVE-IT Research Group, Department of Physical (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1844-1858, December 1, 2021. (Hypertension)

25 October

Hypertension https://www.ahajournals.org/

• 11:00
  Prospective Evaluation of International Prediction of Pregnancy Complications Collaborative Network Models for Prediction of Preeclampsia: Role of Serum sFlt-1 at 11–13 Weeks’ Gestation - Noppadol Chaiyasit Daljit S. Sahota Runmei Ma Mahesh Choolani Tuangsit Wataganara Wen Shan Sim Piya Chaemsaithong Yi Man Isabella Wah Shuk Yi Annie Hui Liona C. Poon From King Chulalongkorn Memorial Hospital, Bangkok, Thailand (Noppadol Chaiyasit) The Chinese University of Hong Kong, Hong Kong SAR (D.S.S., Y.M.I.W., S.Y.A.H., L.C.P.) First Affiliated Hospital of Kunming Medical University, Kunming, China (R.M.) National University Hospital, Singapore (M.C.) Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand (T.W.) KK Women’s and Children’s Hospital, Singapore (...) Hypertension
  Hypertension, Volume 79, Issue 2, Page 314-322, February 1, 2022. The study aimed to investigate whether serum sFlt-1 (soluble fms-like tyrosine kinase-1) at 11-13 weeks’ gestation in pregnancies that subsequently developed preeclampsia was different from those without preeclampsia and compare (...) (Hypertension)
• 11:00
  Systolic Blood Pressure and Mortality in Community-Dwelling Older Adults: Frailty as an Effect Modifier - Kaj-Marko Kremer Ulrike Braisch Dietrich Rothenbacher Michael Denkinger Dhayana Dallmeier Research Unit on Ageing, Agaplesion Bethesda Clinic Ulm, Germany (K.-M.K., U.B., M.D., D.D.). Geriatrisches Zentrum Ulm/Alb-Donau, Ulm, Germany (K.-M.K., U.B., M.D., D.D.). Institute of Geriatric Research (K.-M.K., M.D.), Boston University School of Public Health, Boston, MA Institute of Epidemiology and Medical Biometry (U.B., D.R.), Boston University School of Public Health, Boston, MA Ulm University, Germany. Department of Epidemiology, Boston University School of Public Health, Boston, MA (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 24-32, January 1, 2022. Current evidence is insufficient to support different hypertension treatment targets in older adults. We evaluated whether frailty modifies the association between systolic blood pressure (SBP) and 8-year all-cause mortality in (...) (Hypertension)
• 11:00
  Female Sex and Angiotensin-Converting Enzyme (ACE) Insertion/Deletion Polymorphism Amplify the Effects of Adiposity on Blood Pressure - Martina Chiriacò Domenico Tricò Simone Leonetti John R. Petrie Beverley Balkau Kurt Højlund Zoltan Pataky Peter M Nilsson Andrea Natali Metabolism, Nutrition, and Atherosclerosis Laboratory, Department of Clinical and Experimental Medicine (M.C., D.T., S.L., A.N.), University of Pisa, Italy. Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine (D.T.), University of Pisa, Italy. BHF Glasgow Cardiovascular Research Centre, University of Glasgow, United Kingdom (J.R.P.). Clinical Epidemiology, CESP, University Paris-Saclay, UVSQ, University Paris-Sud, Inserm U1018, (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 36-46, January 1, 2022. The pathophysiological link between adiposity and blood pressure is not completely understood, and evidence suggests an influence of sex and genetic determinants. We aimed to identify the relationship between adiposity and blood (...) (Hypertension)
• 11:00
  Long-Term Exposures to Urban Noise and Blood Pressure Levels and Control Among Older Adults - Jennifer D’Souza Jennifer Weuve Robert D. Brook Denis A. Evans Joel D. Kaufman Sara D. Adar School of Public Health, University of Michigan, Ann Arbor (J.D., S.D.A.). School of Public Health, Boston University, MA (J.W.). Division of Cardiovascular Diseases, Wayne State University, Detroit, MI (R.D.B.). Rush University School of Medicine, Chicago, IL (D.A.E.). School of Public Health, University of Washington, Seattle (J.D.K.). University of Washington School of Medicine, Seattle (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1801-1808, December 1, 2021. (Hypertension)
• 11:00
  Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth - Surawee Chuaiphichai Grace Z. Yu Cheryl M.J. Tan Christopher Whiteman Gillian Douglas Yasmin Dickinson Edward N. Drydale Mahesh Appari Wei Zhang Mark J. Crabtree Eileen McNeill Ashley B. Hale Adam J. Lewandowski Nicholas J. Alp Manu Vatish Paul Leeson Keith M. Channon Division of Cardiovascular Medicine, British Heart Foundation Centre of Research Excellence, Radcliffe Department of Medicine, University of Oxford, United Kingdom (S.C., C.W., G.D., Y.D., E.N.D., M.A., M.J.C., E.M., A.B.H., N.J.A., K.M.C.). Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1871-1884, December 1, 2021. (Hypertension)
• 11:00
  Resolvin E1 Attenuates Pulmonary Hypertension by Suppressing Wnt7a/?-Catenin Signaling - Guizhu Liu Naifu Wan Qian Liu Yuqin Chen Hui Cui Yuanyang Wang Jiaoqi Ren Xia Shen Wenju Lu Ying Yu Yujun Shen Jian Wang From the State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China (G.L., Y.C., W.L., Y.Y., J.W.) Department of Medicine, University of California, San Diego, La Jolla (J.W.) Department of Cardiology, Ruijin Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, China (N.W.) School of Life Science and Technology, Shanghai Tech (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1914-1926, December 1, 2021. (Hypertension)

18 October

Hypertension https://www.ahajournals.org/

• 11:00
  Blood Pressure and Arterial Stiffness in Association With Aircraft Noise Exposure:Long-Term Observation and Potential Effect of COVID-19 Lockdown - Wiktoria Wojciechowska Andrzej Januszewicz Tomasz Dro?d? Marta Rojek Justyna B?czalska Micha? Terlecki Karol Kurasz Agnieszka Olszanecka Miko?aj Smólski Aleksander Prejbisz Piotr Dobrowolski Tomasz Grodzicki Tomasz Hryniewiecki Reinhold Kreutz Marek Rajzer From the Jagiellonian University Medical College, 1st Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Kraków, Poland (W.W., T.D., M. Rojek, J.B., M.T., A.O., M.R.); Department of Hypertension, National Institute of Cardiology, Warsaw, Poland (A.J., M.S., A.P., P.D.); Medical Faculty, Dresden (...) Hypertension
  Hypertension, Volume 79, Issue 2, Page 325-334, February 1, 2022. In a cross-sectional analysis of a case-control study in 2015, we revealed the association between increased arterial stiffness (pulse wave velocity) and aircraft noise exposure. In June 2020, we evaluated the long-term effects, (...) (Hypertension)
• 11:00
  Screening Rates for Primary Aldosteronism Among Individuals With Hypertension Plus Hypokalemia: A Population-Based Retrospective Cohort Study - Gregory L. Hundemer Haris Imsirovic Anand Vaidya Nicholas Yozamp Rémi Goupil François Madore Mohsen Agharazii Greg Knoll Manish M. Sood Department of Medicine (Division of Nephrology) and the Ottawa Hospital Research Institute, University of Ottawa, ON, Canada (G.L.H., G.K., M.M.S.). Institute for Clinical Evaluative Sciences, Ottawa, Canada (H.I., M.M.S.). Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (A.V., N.Y.). Department of Medicine (Division of Nephrology), Hôpital du Sacré-Coeur de (...) Hypertension
  Hypertension, Volume 79, Issue 1, Page 178-186, January 1, 2022. Primary aldosteronism is a common, yet highly underdiagnosed, cause of hypertension that leads to disproportionately high rates of cardiovascular disease. Hypertension plus hypokalemia is a guideline-recommended indication to (...) (Hypertension)
• 11:00
  Knockout of Macula Densa Neuronal Nitric Oxide Synthase Increases Blood Pressure in db/db Mice - Jie Zhang Ximing Wang Yu Cui Shan Jiang Jin Wei Jenna Chan Anish Thalakola Thanh Le Lan Xu Liang Zhao Lei Wang Kun Jiang Feng Cheng Trushar Patel Jacentha Buggs Volker Vallon Ruisheng Liu Department of Molecular Pharmacology and Physiology (J.Z., X.W., S.J., J.W., J.C., A.T., T.L., L.W., R.L.), University of South Florida, Tampa. Department of Urology (T.P.), University of South Florida, Tampa. College of Medicine, College of Public Health (L.X.), University of South Florida, Tampa. Department of Pharmaceutical Science, College of Pharmacy (F.C.), University of South Florida, Tampa. (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1760-1770, December 1, 2021. (Hypertension)
• 11:00
  Subtypes of Histopathologically Classical Aldosterone-Producing Adenomas Yield Various Transcriptomic Signaling and Outcomes - Vin-Cent Wu Kang-Yung Peng Yu-Ping Kuo Hsuan Liu Bertrand Chin-Ming Tan Yen-Hung Lin Tai-Shuan Lai Yung-Ming Chen Jeff S Chueh Division of Nephrology (V.-C.W., T.-S.L., Y.-M.C.), National Taiwan University Hospital, Taipei. Division of Cardiology, Department of Internal Medicine (Y.-H.L.), National Taiwan University Hospital, Taipei. Department of Urology, College of Medicine (J.S.C.), National Taiwan University Hospital, Taipei. Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan (H.L., K.-Y.P.). Graduate Institute of Biomedical Sciences (H.L., B.C.-M.T.), Chang (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1791-1800, December 1, 2021. (Hypertension)
• 11:00
  First-in-Human Study of MANP: A Novel ANP (Atrial Natriuretic Peptide) Analog in Human Hypertension - Horng H. Chen Siu-Hin Wan Seethalakshmi R. Iyer Valentina Cannone S. Jeson Sangaralingham Joel Nuetel John C. Burnett Cardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester MN (H.H.C., S.R.I., J.S., J.C.B.). Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (S.-H.W.). Department of Internal Medicine, University of Parma, Parma, Italy (V.C.). Integrium, Tustin, CA (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1859-1867, December 1, 2021. (Hypertension)
• 11:00
  Enhanced Sp1/YY1 Expression Directs CBS Transcription to Mediate VEGF-Stimulated Pregnancy-Dependent H2S Production in Human Uterine Artery Endothelial Cells - Jin Bai Dong-bao Chen Department of Obstetrics and Gynecology, University of California, Irvine. Hypertension
  Hypertension, Volume 78, Issue 6, Page 1902-1913, December 1, 2021. (Hypertension)

7 October

Hypertension https://www.ahajournals.org/

• 11:00
  Medication Adherence and Blood Pressure Control: A Scientific Statement From the American Heart Association - Niteesh K. Choudhry Ian M. Kronish Wanpen Vongpatanasin Keith C. Ferdinand Valory N. Pavlik Brent M. Egan Antoinette Schoenthaler Nancy Houston Miller David J. Hyman Hypertension
  Hypertension, Volume 79, Issue 1, Page e1-e14, January 1, 2022. The widespread treatment of hypertension and resultant improvement in blood pressure have been major contributors to the dramatic age-specific decline in heart disease and stroke. Despite this progress, a persistent gap remains (...) (Hypertension)

7 September

Hypertension https://www.ahajournals.org/

• 11:00
  Negative Influence of Insufficient Sleep on Endothelial Vasodilator and Fibrinolytic Function in Hypertensive Adults - Kelly A. Stockelman Anthony R. Bain Anabel Goulding Noah M. DeSouza Clay Rahaman Lukas Maly Jared J. Greiner Brian L. Stauffer Christopher A. DeSouza Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado Boulder (K.A.S., A.G., N.M.D., C.R., L.M., J.J.G., C.A.D.). Department of Kinesiology, University of Windsor, ON, Canada (A.R.B.). Department of Medicine, Anschutz Medical Center, University of Colorado Denver (B.L.S., C.A.D.). Department of Medicine, Division of Cardiology, Denver Health Medical Center, CO (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1829-1840, December 1, 2021. (Hypertension)

9 August

Hypertension https://www.ahajournals.org/

• 11:00
  Racial/Ethnic Disparities in Hypertension Prevalence, Awareness, Treatment, and Control in the United States, 2013 to 2018 - Rahul Aggarwal Nicholas Chiu Rishi K. Wadhera Andrew E. Moran Inbar Raber Changyu Shen Robert W. Yeh Dhruv S. Kazi Department of Medicine (R.A., N.C., R.K.W., I.R.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Division of Cardiology (R.A., N.C., R.K.W., I.R., C.S., R.W.Y., D.S.K.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Division of General Medicine, Columbia University, New York, NY (...) Hypertension
  Hypertension, Volume 78, Issue 6, Page 1719-1726, December 1, 2021. (Hypertension)