30 June

Hypertension https://www.ahajournals.org/

• 11:00
  Seasonal Variation in Day-by-Day Home Blood Pressure Variability and Effect on Cardiovascular Disease Incidence - Keisuke Narita Satoshi Hoshide Kazuomi Kario Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University School of Medicine, Tochigi, Japan. Hypertension
  Hypertension, Ahead of Print. Background:Although day-by-day home blood pressure (BP) variability (BPV) has been associated with cardiovascular disease (CVD) risk, it remains unclear whether this association differs from season to season. The present study aimed to assess seasonal variation in (...) (Hypertension)

29 June

Hypertension https://www.ahajournals.org/

• 11:02
  Influence of Obstructive Sleep Apnea Severity on Muscle Sympathetic Nerve Activity and Blood Pressure: a Systematic Review and Meta-Analysis - Lauren E. Maier Brittany A. Matenchuk Ana Vucenovic Allison Sivak Margie H. Davenport Craig D. Steinback Neurovascular Health Laboratory, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Canada. (L.E.M., A.V., C.D.S.) Program for Pregnancy and Postpartum Health, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Canada. (B.A.M., M.H.D.) H.T. Coutts Education and Physical Education Library, University of Alberta, Edmonton, Canada. (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:We conducted meta-analyses to identify relationships between obstructive sleep apnea (OSA) severity, muscle sympathetic nerve activity (MSNA), and blood pressure (BP). We quantified the effect of OSA treatment on MSNA.METHODS:Structured searches of (...) (Hypertension)
• 11:01
  Aldosterone as a Mediator of Cardiovascular Damage - Fabrizio Buffolo Martina Tetti Paolo Mulatero Silvia Monticone Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Torino, Italy. Hypertension
  Hypertension, Ahead of Print. Besides the physiological regulation of water, sodium, and potassium homeostasis, aldosterone modulates several physiological and pathological processes in the cardiovascular system. At the vascular level, aldosterone excess stimulates endothelial dysfunction and (...) (Hypertension)
• 11:01
  Age and Blood Pressure Contribute to Aortic Cell and Tissue Stiffness Through Distinct Mechanisms - Ben Ma Elaina Melton Robert Wiener Ning Zhou Wenqian Wu Lo Lai Charles Wang Kevin D. Costa Hongyu Qiu Center for Molecular and Translational Medicine, Institute of Biomedical Sciences, Georgia State University, Atlanta, GA (B.M., E.M., W.W., L.L., H.Q.). Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY (R.W., K.D.C.). Division of Physiology, Department of Basic Sciences, School of Medicine, Loma Linda University, CA (B.M., N.Z., H.Q.) Department of Basic Sciences & Center for Genomics, School of Medicine, Loma (...) Hypertension
  Hypertension, Ahead of Print. Background:Aortic stiffening is strongly associated with both aging and hypertension, but the underlying mechanisms remain unclear. We hypothesized that aging-induced aortic stiffness involves distinct pathways than stiffening from hypertension.Methods:We conducted (...) (Hypertension)
• 11:00
  Angiotensin Receptor Blockers Are Associated With a Lower Risk of Progression From Mild Cognitive Impairment to Dementia - Zhenhong Deng Jingru Jiang Jia Wang Dong Pan Yingying Zhu Honghong Li Xiaoni Zhang Xiaohuan Liu Yongteng Xu Yi Li Yamei Tang Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. (Z.D., J.J., J.W., D.P., Y.Z., H.L., X.Z.,X.L., Y.X., Y.L., Y.T.) Division of Clinical Research Design, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. (Y.Z., Y.T.) Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. (Y.T.) Guangdong (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Previous studies found that antihypertensive medications (AHMs) acting on the renin-angiotensin system had the potential to reduce the progression from mild cognitive impairment to dementia. However, it remains unclear whether this association differs (...) (Hypertension)
• 11:00
  Blood Pressure Intervention and Control in the SPRINT - William C. Cushman Robert J. Ringer Carlos J. Rodriguez Gregory W. Evans Jeffrey T. Bates Jeffrey A. Cutler Amret Hawfield Dalane W. Kitzman Ilya M. Nasrallah Suzanne Oparil John Nord Vasilios Papademetriou Karen Servilla Peter Van Buren Paul K. Whelton Jeff Whittle Jackson T. Wright Department of Preventive Medicine, University of Tennessee Health Science Center, and Medical Service, Veterans Affairs Medical Center, Memphis (W.C.C.). Department of Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (R.J.R.). Departments of (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:The SPRINT (Systolic Blood Pressure Intervention Trial) demonstrated reductions in major cardiovascular disease events and mortality with an intensive systolic blood pressure (SBP) goal intervention. However, a detailed description of the blood pressure (...) (Hypertension)

28 June

Hypertension https://www.ahajournals.org/

• 11:00
  Association of Blood Pressure–Related Increase in Vascular Stiffness on Other Measures of Target Organ Damage in Youth - Jessica E. Haley Shalayna A. Woodly Stephen R. Daniels Bonita Falkner Michael Ferguson Joseph T. Flynn Coral Hanevold Stephen R. Hooper Julie R. Ingelfinger Philip R. Khoury Marc B. Lande Lisa J. Martin Kevin E. Meyers Mark Mitsnefes Richard C. Becker Bernard Rosner Joshua Samuels Andrew Tran Elaine Urbina Rady Children’s Hospital San Diego, CA (J.E.H.). Cincinnati Children’s Hospital Medical Center, OH (S.A.W., P.R.K., L.J.M., M.M., R.C.B., A.T., E.U.). Children’s Hospital Colorado, Denver (S.R.D.). Thomas Jefferson University (B.F.). Boston Children’s Hospital (M.F.). Department of (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Hypertension-related increased arterial stiffness predicts development of target organ damage (TOD) and cardiovascular disease. We hypothesized that blood pressure (BP)–related increased arterial stiffness is present in youth with elevated BP and is (...) (Hypertension)
• 11:00
  Antenatal Dexamethasone Exposure Impairs Vascular Contractile Functions via Upregulating IP3 Receptor 1 and Cav1.2 in Adult Male Offspring - Ting Xu Bingyu Ji Lingjun Li Jiahui Lei Meng Zhao Miao Sun Zhice Xu Qinqin Gao Institute for Fetology, First Hospital of Soochow University, Suzhou, China (T.X., B.J., L.L., J.L., M.Z., M.S., Z.X., Q.G.). Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Administration of antenatal glucocorticoids remains common practice for treating preterm delivery. Antenatal glucocorticoid exposure increased the risk of developing vascular diseases in later life, but the precise mechanisms remain unclear. This study (...) (Hypertension)

22 June

Hypertension https://www.ahajournals.org/

• 11:00
  Voluntary Exercise Eliminates Maternal Gestational Hypertension–Induced Hypertensive Response Sensitization to Postweaning High-Fat Diet in Male Adult Offspring - Baojian Xue Yang Yu Terry G. Beltz Fang Guo Shun-Guang Wei Alan Kim Johnson Departments of Psychological and Brain Sciences, University of Iowa, Iowa City. (B.X., T.G.B., F.G., A.K.J.) Neuroscience and Pharmacology, University of Iowa, Iowa City. (A.K.J.) Health and Human Physiology, University of Iowa, Iowa City. (A.K.J.) Internal Medicine, University of Iowa, Iowa City. (Y.Y., S.-G.W.) the François M. Abboud Cardiovascular Research Center, University of Iowa, Iowa City. (S.-G.W., (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Exercise has profound effects on cardiovascular function and metabolism in both physiological and pathophysiological states. The present study tested whether voluntary exercise would protect male offspring against maternal gestational (...) (Hypertension)

21 June

Hypertension https://www.ahajournals.org/

• 11:00
  Cathepsin K Deficiency Prevented Kidney Damage and Dysfunction in Response to 5/6 Nephrectomy Injury in Mice With or Without Chronic Stress - Xueling Yue Limei Piao Hailong Wang Zhe Huang Xiangkun Meng Takeshi Sasaki Aiko Inoue Kae Nakamura Ying Wan Shengnan Xu Guo-Ping Shi Weon Kim Toyoaki Murohara Masafumi Kuzuya Xian Wu Cheng Department of Cardiology and Hypertension, Yanbian University Hospital, Yanji, Jilin, People's Republic of China (X.Y., L.P., H.W., Z.H., X.M., Y.W., S.X., X.W.C.). Department of Community Health Care and Geriatrics, Nagoya University Graduate School of Medicine, Japan. (X.Y., Z.H., X.M., M.K.) Institute of Innovation for Future Society, Nagoya University Graduate School of Medicine, Japan. (A.I., M.K.) (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Chronic psychological stress is a risk factor for kidney disease, including kidney dysfunction and hypertension. Lysosomal CatK (cathepsin K) participates in various human pathobiologies. We investigated the role of CatK in kidney remodeling and (...) (Hypertension)
• 11:00
  Digital Therapeutics in Hypertension: Evidence and Perspectives - Kazuomi Kario Noriko Harada Ayako Okura Division of Cardiovascular Medicine, School of Medicine, Jichi Medical University, Tochigi, Japan. Hypertension
  Hypertension, Ahead of Print. Digital therapeutics refers to the use of evidence-based therapeutic interventions driven by high-quality software programs to treat, manage, or prevent a medical condition. This approach is being increasingly investigated for the management of hypertension, a (...) (Hypertension)

20 June

Hypertension https://www.ahajournals.org/

• 11:00
  Variation in Mean Arterial Pressure Increases Falls Risk in Elderly Physically Frail and Prefrail Individuals Treated With Antihypertensive Medication - Sultana Monira Hussain Michael E. Ernst Anna L. Barker Karen L. Margolis Christopher M. Reid Johannes T. Neumann Andrew M. Tonkin Thao Le Thi Phuong Lawrence J Beilin Thao Pham Enayet K. Chowdhury Flavia M. Cicuttini Julia Gilmartin-Thomas Prudence R. Carr John J McNeil School of Public Health and Preventive Medicine, Monash University, Victoria, Australia (S.M.H., A.L.B., C.M.R., J.T.N., A.M.T., T.L.T.P., T.P., E.K.C., F.M.C., J.G.-T., P.R.C., J.J.M.). Department of Medical Education, Melbourne Medical School, The University of Melbourne, Victoria, Australia. (S.M.H.) Department of (...) Hypertension
  Hypertension, Ahead of Print. Background:Impaired cerebral blood flow has been associated with an increased risk of falls. Mean arterial pressure (MAP) and variability in MAP have been reported to affect cerebral blood flow but their relationships to the risk of falls have not previously been (...) (Hypertension)

16 June

Hypertension https://www.ahajournals.org/

• 11:00
  Effects of a Liquefied Petroleum Gas Stove Intervention on Gestational Blood Pressure: Intention-to-Treat and Exposure-Response Findings From the HAPIN Trial - Wenlu Ye Kyle Steenland Ashlinn Quinn Jiawen Liao Kalpana Balakrishnan Ghislaine Rosa Florien Ndagijimana Jean de Dieu Ntivuguruzwa Lisa M. Thompson John P. McCracken Anaité Díaz-Artiga Joshua P. Rosenthal Aris Papageorghiou Victor G. Davila-Roman Ajay Pillarisetti Michael Johnson Jiantong Wang Laura Nicolaou William Checkley Jennifer L. Peel Thomas F. Clasen Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA. (W.Y., K.S., A. Pillarisetti, T.F.C.) Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA. (L.M.T.) (...) Hypertension
  Hypertension, Ahead of Print. Background:Approximately 3 to 4 billion people worldwide are exposed to household air pollution, which has been associated with increased blood pressure (BP) in pregnant women in some studies.Methods:We recruited 3195 pregnant women in Guatemala, India, Peru, and (...) (Hypertension)
• 11:00
  Revascularization for Renovascular Disease: A Scientific Statement From the American Heart Association - Vivek Bhalla Stephen C. Textor Joshua A. Beckman Ana I. Casanegra Christopher J. Cooper Esther S.H. Kim James M. Luther Sanjay Misra Gustavo S. Oderich Hypertension
  Hypertension, Ahead of Print. Renovascular disease is a major causal factor for secondary hypertension and renal ischemic disease. However, several prospective, randomized trials for atherosclerotic disease failed to demonstrate that renal revascularization is more effective than medical (...) (Hypertension)
• 06:00
  Control of Blood Pressure and Risk of Cardiovascular Disease and Mortality in Elderly Chinese: A Real-World Prospective Cohort Study - Anxin Wang Xue Tian Yingting Zuo Shuohua Chen Yijun Zhang Xiaoli Zhang Xuan Deng Qin Xu Penglian Wang Shouling Wu Yong Zhou Department of Neurology, Beijing Tiantan Hospital (A.W., X.T., Y. Zuo, Y. Zhang, X.Z., Q.X., P.W.) China National Clinical Research Center for Neurological Diseases (A.W., X.T., Y. Zuo, Y. Zhang, X.Z., Q.X., P.W.) Department of Epidemiology and Health Statistics, School of Public Health (X.T., Y. Zuo) Capital Medical University. Beijing Municipal Key Laboratory of Clinical Epidemiology, China (X.T., Y. Zuo). Department of Cardiology, Kailuan Hospital, North China (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:The STEP trial (Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients) showed that older hypertensive patients might benefit from a target systolic blood pressure (SBP) of 110 (...) (Hypertension)

15 June

Hypertension https://www.ahajournals.org/

• 11:00
  SGLT2 Inhibition via Empagliflozin Improves Endothelial Function and Reduces Mitochondrial Oxidative Stress: Insights From Frail Hypertensive and Diabetic Patients - Pasquale Mone Fahimeh Varzideh Stanislovas S. Jankauskas Antonella Pansini Angela Lombardi Salvatore Frullone Gaetano Santulli Asl Avellino, Albert Einstein College of Medicine, New York, NY. (P.M., A.P., S.F.). Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, New York, NY. (P.M., F.V., S.S.J., A.L., G.S.) Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY. (G.S.) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Frailty is a multidimensional condition often diagnosed in older adults with hypertension and diabetes, and both these conditions are associated with endothelial dysfunction and oxidative stress. We investigated the role of the SGLT2 (sodium glucose (...) (Hypertension)

13 June

Hypertension https://www.ahajournals.org/

• 11:00
  Per- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women's Health Across the Nation - Ning Ding Carrie A. Karvonen-Gutierrez Bhramar Mukherjee Antonia M. Calafat Siobán D. Harlow Sung Kyun Park Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor. (N.D., C.A.K.-G., S.D.H., S.K.P.) Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor. (B.M.) Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor. (S.K.P.) Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA (...) Hypertension
  Hypertension, Ahead of Print. Background:Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are ubiquitous synthetic chemicals that may disrupt blood pressure controls; however, human evidence to support this hypothesis is scant. We examined the association between serum concentrations of (...) (Hypertension)

10 June

Hypertension https://www.ahajournals.org/

• 11:00
  Management and Outcomes of Primary Aldosteronism in Pregnancy: A Systematic Review - Viola Sanga Giacomo Rossitto Teresa Maria Seccia Gian Paolo Rossi Hypertension and Emergency Unit, Department of Medicine - DIMED, University of Padua, Italy. (V.S., T.M.S., G.P.R.) PhD Arterial Hypertension and Vascular Biology, Department of Medicine - DIMED, University of Padua, Italy. (V.S.) Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (G.R.). Hypertension
  Hypertension, Ahead of Print. Primary aldosteronism (PA) in pregnancy (PAP) can be a serious condition and is challenging to diagnose. This study was conceived to help in the diagnosis of PAP and provide suggestions on management of PAP based on evidence retrieved using a Population, (...) (Hypertension)
• 11:00
  IsoLGs (Isolevuglandins) Drive Neutrophil Migration in Hypertension and Are Essential for the Formation of Neutrophil Extracellular Traps - Jaya Krishnan Néstor de la Visitación Elizabeth M. Hennen Venkataraman Amarnath David G. Harrison David M. Patrick Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center. (J.K., N.d.l.V., V.A., D.G.H., D.M.P.) Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center. (D.G.H., D.M.P.) Department of Biomedical Engineering, Vanderbilt University (E.M.H.). Department of Veterans Affairs, Nashville, TN (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:IsoLGs (isolevuglandins) are electrophilic products of lipid peroxidation formed in the presence of reactive oxygen species. IsoLGs contribute to hypertension by an unknown mechanism. Studies have shown that reactive oxygen species production drives the (...) (Hypertension)
• 11:00
  Effects of Ramipril on Biomarkers of Endothelial Dysfunction and Inflammation in Hypertensive Children on Maintenance Hemodialysis: the SEARCH Randomized Placebo-Controlled Trial - Areej Mohamed Ateya Ihab El Hakim Sara Mahmoud Shahin Radwa El Borolossy Reinhold Kreutz Nagwa Ali Sabri Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.M.A., S.M.S., R.E.B., N.A.S.). Charité – Universitätsmedizin Berlin, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany (A.M.A., R.K.). Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt (I.E.H.). Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Hypertension, endothelial dysfunction, and inflammation are associated with increased cardiovascular mortality in end-stage kidney disease. We evaluated the effects of ACE (angiotensin-converting enzyme) inhibition on biomarkers of endothelial (...) (Hypertension)

8 June

Hypertension https://www.ahajournals.org/

• 11:00
  Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na+/H+ Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway - Xiaoliang Jiang Yunpeng Liu Xin-Yang Zhang Xue Liu Xing Liu Xianxian Wu Pedro A. Jose Shun Duan Fu-Jian Xu Zhiwei Yang NHC Key Laboratory of Human Disease Comparative Medicine (The Institute of Laboratory Animal Sciences, CAMS&PUMC), National Human Diseases Animal Model Resource Center, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, P.R. China (X.J., Y.L., Xue Liu, Xing Liu, X.W., Z.Y.). Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education, Beijing Laboratory of (...) Hypertension
  Hypertension, Ahead of Print. Background:The present study directly tested the crucial role of intestinal gastrin/CCKBR (cholecystokinin B receptor) in the treatment of salt-sensitive hypertension.Methods:Adult intestine-specificCckbr-knockout mice (Cckbrfl/flvillin-Cre) and Dahl salt-sensitive (...) (Hypertension)
• 11:00
  Association Between the Gut Microbiome and Their Metabolites With Human Blood Pressure Variability - Evany Dinakis Michael Nakai Paul Gill Rosilene Ribeiro Stephanie Yiallourou Yusuke Sata Jane Muir Melinda Carrington Geoffrey A. Head David M. Kaye Francine Z. Marques Hypertension Research Laboratory, School of Biological Sciences, Monash University, Melbourne, Australia. (E.D., M.N.) Department of Gastroenterology, Monash University, Melbourne, Australia. (P.G., J.M.) Central Clinical School, Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, Australia. (Y.S., D.M.K.) Department of Pharmacology, Faculty of Medicine Nursing and Health Sciences, Monash (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Blood pressure (BP) variability is an independent risk factor for cardiovascular events. Recent evidence supports a role for the gut microbiota in BP regulation. However, whether the gut microbiome is associated with BP variability is yet to be (...) (Hypertension)
• 08:00
  Correction to: Prospective Evaluation of International Prediction of Pregnancy Complications Collaborative Network Models for Prediction of Preeclampsia: Role of Serum sFlt-1 at 11–13 Weeks’ Gestation Hypertension
  Hypertension, Volume 79, Issue 7, Page e113-e113, July 1, 2022. (Hypertension)
• 11:00
  MANP (Mutant Atrial Natriuretic Peptide) Activation of the cGMP (3’,5’, Cyclic Guanosine Monophosphate) Inhibits Aldosterone via PDE2 (Phosphodiesterase 2) and Cytochrome p450 Family 11 Subfamily b Member 2 in H295R Cells and in Mice - Yang Chen Seethalakshmi R. Iyer Viacheslav O. Nikolaev Fabio Naro Manuela Pellegrini Silvia Cardarelli Xiao Ma Hon-Chi Lee John C. Burnett Cardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester MN. (Y.C., S.R.I., X.M., J.C.B.) Department of Cardiovascular Medicine, Mayo Clinic, Rochester MN. (H.-C.L.) Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia (Y.C.). Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Germany (V.O.N.). Department of Anatomical, Histological, (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Aldosterone is a critical pathological driver for cardiac and renal diseases. We recently discovered that MANP (mutant atrial natriuretic peptide), a novel ANP (atrial natriuretic peptide) analog, possessed more potent aldosterone inhibitory action than (...) (Hypertension)

6 June

Hypertension https://www.ahajournals.org/

• 11:00
  Uric Acid and Hypertension: a Review of Evidence and Future Perspectives for the Management of Cardiovascular Risk - Claudio Borghi Davide Agnoletti Arrigo Francesco Giuseppe Cicero Empar Lurbe Agostino Virdis Department of Medical and Surgical Science-IRCCS S.Orsola, University of Bologna, Italy (C.B., D.A., A.F.G.C.). Department of Pediatrics, University of Valencia, Spain (E.L.). Department of Clinical and Experimental Medicine, University of Pisa, Italy (A.V.). Hypertension
  Hypertension, Ahead of Print. Uric acid is the final product of purine metabolism, and its increased serum levels have been directly involved in the pathogenesis and natural history of hypertension. The relationship between elevated uric acid and hypertension has been proven in both animals and (...) (Hypertension)