18 May

Circulation http://ahajournals.org/

• 11:00
  Indoleamine 2,3-Dioxygenase 1 Deletion–Mediated Kynurenine Insufficiency in Vascular Smooth Muscle Cells Exacerbates Arterial Calcification - Liu Ouyang Changjiang Yu Zhiyong Xie Xiaoyan Su Zengmei Xu Ping Song Jian Li Hui Huang Ye Ding Ming-Hui Zou Center for Molecular and Translational Medicine, Georgia State University, Atlanta (L.Q., C.J.Y., P.S., J.L., Y.D., M.H.Z.). School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, China (Z. Xie, Z. Xu). Department of Nephropathy, Tungwah Hospital of Sun Yat-sen University, Dongguan, China (X.S.). Department of Cardiology, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:IDO1 (indoleamine 2,3-dioxygenase 1) is the rate-limiting enzyme for tryptophan metabolism. IDO1 malfunction is involved in the pathogenesis of atherosclerosis. Vascular smooth muscle cells (VSMCs) with an osteogenic phenotype promote calcification and (...) (Circulation)

16 May

Circulation http://ahajournals.org/

• 08:00
  Correction to: Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications Circulation
  Circulation, Volume 145, Issue 20, Page e1053-e1053, May 17, 2022. (Circulation)
• 08:00
  A Role for the Vascular Endothelium in Post–Acute COVID-19? - Laura P.M.H. de Rooij Lisa M. Becker Peter Carmeliet Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, Vlaams Instituut voor Biotechnologie and Department of Oncology, Leuven Cancer Institute, Katholieke Universiteit Leuven, Belgium (L.P.M.H.d.R., L.M.B., P.C.). State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong, China (P.C.). Laboratory of Angiogenesis and Vascular Heterogeneity, Department of Biomedicine, Aarhus University, Denmark (P.C.). Center for Biotechnology, Khalifa University of Science (...) Circulation
  Circulation, Volume 145, Issue 20, Page 1503-1505, May 17, 2022. (Circulation)
• 08:00
  What Eggsactly Are We Asking Here? Unscrambling the Epidemiology of Eggs, Cholesterol, and Mortality - Deirdre K. Tobias Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA. Nutrition Department, Harvard TH Chan School of Public Health, Boston, MA. Circulation
  Circulation, Volume 145, Issue 20, Page 1521-1523, May 17, 2022. (Circulation)

12 May

Circulation http://ahajournals.org/

• 11:00
  Cardiovascular Outcomes in Collegiate Athletes Following SARS-CoV-2 Infection: 1-year Follow-up from the Outcomes Registry for Cardiac Conditions in Athletes - Bradley J. Petek Nathaniel Moulson Jonathan A. Drezner Kimberly G. Harmon Stephanie A. Kliethermes Timothy W. Churchill Manesh R. Patel Aaron L. Baggish Massachusetts General Hospital, Division of Cardiology, Boston, MA; Massachusetts General Hospital, Cardiovascular Performance Program, Boston, MA Division of Cardiology and Sports Cardiology BC, University of British Columbia, Vancouver, Canada Department of Family Medicine and Center for Sports Cardiology, University of Washington, Seattle, WA Department of Orthopedics and Rehabilitation, University of Wisconsin Madison, Madison, WI (...) Circulation
  Circulation, Ahead of Print. (Circulation)

10 May

Circulation http://ahajournals.org/

• 11:01
  Rapid Exclusion of Acute Myocardial Injury and Infarction with a Single High Sensitivity Cardiac Troponin T in the Emergency Department: a Multicenter United States Evaluation - Yader Sandoval Bradley R. Lewis Ramila A. Mehta Olatunde Ola Jonathan D. Knott Laura De Michieli Ashok Akula Ronstan Lobo Eric H. Yang S. Michael Gharacholou Marshall Dworak Erika Crockford Nicholas Rastas Eric Grube Swetha Karturi Scott Wohlrab David O. Hodge Tahir Tak Charles Cagin Rajiv Gulati Allan S. Jaffe Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN Department of Health Sciences Research, Mayo College of Medicine, Rochester, MN Division of Hospital Internal Medicine, Mayo Clinic Health (...) Circulation
  Circulation, Ahead of Print. Background: There are good data to support using a single high-sensitivity cardiac troponin T (hs-cTnT) below the limit of detection (LoD) of 5 ng/L to exclude acute myocardial infarction. Per the United States (US) Food and Drug Administration (FDA), hs-cTnT can (...) (Circulation)
• 11:00
  Strengthening US Food Policies and Programs to Promote Equity in Nutrition Security: A Policy Statement From the American Heart Association - Anne N. Thorndike Christopher D. Gardner Katherine Bishop Kendrick Hilary K. Seligman Amy L. Yaroch Aldrin V. Gomes Kendra N. Ivy Stephanie Scarmo Caree Jackson Cotwright Marlene B. Schwartz Circulation
  Circulation, Ahead of Print. Nutritionally inadequate dietary intake is a leading contributor to chronic cardiometabolic diseases. Differences in dietary quality contribute to socioeconomic and racial and ethnic health disparities. Food insecurity, a household-level social or economic condition (...) (Circulation)

9 May

Circulation http://ahajournals.org/

• 11:00
  Call to Action for Cardiovascular Disease in Women: Epidemiology, Awareness, Access, and Delivery of Equitable Health Care: A Presidential Advisory From the American Heart Association - Nanette K. Wenger Donald M. Lloyd-Jones Mitchell S.V. Elkind Gregg C. Fonarow John J. Warner Heather M. Alger Susan Cheng Claire Kinzy Jennifer L. Hall Véronique L. Roger Circulation
  Circulation, Ahead of Print. Addressing the pervasive gaps in knowledge and care delivery to reduce sex-based disparities and achieve equity is fundamental to the American Heart Association’s commitment to advancing cardiovascular health for all by 2024. This presidential advisory serves as a (...) (Circulation)
• 08:00
  From the Literature - Tracy Hampton Circulation
  Circulation, Volume 145, Issue 19, Page 1497-1498, May 10, 2022. (Circulation)
• 08:00
  Text Messages to Improve Medication Adherence and Secondary Prevention After Acute Coronary Syndrome: The TEXTMEDS Randomized Clinical Trial - Clara K. Chow Harry Klimis Aravinda Thiagalingam Julie Redfern Graham S. Hillis David Brieger John Atherton Ravinay Bhindi Derek P. Chew Nicholas Collins Michael Andrew Fitzpatrick Craig Juergens Nadarajah Kangaharan Andrew Maiorana Michele McGrady Rohan Poulter Pratap Shetty Jonathon Waites Christian Hamilton Craig Peter Thompson Sandrine Stepien Amy Von Huben Anthony Rodgers Westmead Applied Research Institute (C.K.C., H.K., A.T., A.V.H., A.R.), University of Sydney, Australia. Faculty of Medicine and Health (J.R., R.B., M.A.F., M.M.), University of Sydney, Australia. ANZAC Research (...) Circulation
  Circulation, Volume 145, Issue 19, Page 1443-1455, May 10, 2022. Background:TEXTMEDS (Text Messages to Improve Medication Adherence and Secondary Prevention After Acute Coronary Syndrome) examined the effects of text message–delivered cardiac education and support on medication adherence after (...) (Circulation)
• 08:00
  Letter by Ren and Yang Regarding Article, “Retention of the NLRP3 Inflammasome–Primed Neutrophils in the Bone Marrow Is Essential for Myocardial Infarction–Induced Granulopoiesis” - Chuanli Ren Zhangjun Yang Department of Laboratory Medicine, Clinical Medical College of Yangzhou University, China (C.R.). Department of Chemistry, Yangzhou University, China (Z.Y.). Circulation
  Circulation, Volume 145, Issue 19, Page e1034-e1034, May 10, 2022. (Circulation)
• 08:00
  Response by Nagareddy and Sreejit to Letter Regarding Article, “Retention of the NLRP3 Inflammasome-Primed Neutrophils in the Bone Marrow Is Essential for Myocardial Infarction–Induced Granulopoiesis” - Prabhakara R. Nagareddy Gopalkrishna Sreejit Division of Cardiac Surgery, Department of Surgery, Ohio State University Wexner Medical Center, Columbus. Circulation
  Circulation, Volume 145, Issue 19, Page e1035-e1036, May 10, 2022. (Circulation)
• 08:00
  Circulation Best Papers 2021 - Joseph A. Hill Darren K. McGuire James A. de Lemos Department of Medicine (Cardiology) (J.A.H., D.K.M., J.A.d.L.), UT Southwestern Medical Center, Dallas. Department of Molecular Biology (J.A.H.), UT Southwestern Medical Center, Dallas. Parkland Health and Hospital System, Dallas, TX (D.K.M.). Circulation
  Circulation, Volume 145, Issue 19, Page 1441-1442, May 10, 2022. (Circulation)
• 08:00
  Opportunities and Challenges of Mobile Health Tools to Promote Health Behaviors - Abhinav Sharma Robert Avram DREAM-CV Lab, McGill University Health Centre, Montreal, QC, Canada (A.S.). Division of Cardiology, Department of Medicine, McGill University, Montreal, QC, Canada (A.S.). Division of Cardiology, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (R.A.). Circulation
  Circulation, Volume 145, Issue 19, Page 1456-1459, May 10, 2022. (Circulation)
• 06:55
  rECHOmmend: An ECG-based Machine-learning Approach for Identifying Patients at High-risk of Undiagnosed Structural Heart Disease Detectable by Echocardiography - Alvaro E. Ulloa-Cerna Linyuan Jing John M. Pfeifer Sushravya Raghunath Jeffrey A. Ruhl Daniel B. Rocha Joseph B. Leader Noah Zimmerman Greg Lee Steven R. Steinhubl Christopher W. Good Christopher M. Haggerty Brandon K. Fornwalt RuiJun Chen Department of Translational Data Science and Informatics, Geisinger, Danville, PA Department of Translational Data Science and Informatics, Geisinger, Danville, PA; Heart and Vascular Center, Evangelical Hospital, Lewisburg, PA; Tempus Labs Inc, Chicago, IL Department of Translational Data Science and Informatics, Geisinger, Danville, PA; Tempus Labs (...) Circulation
  Circulation, Ahead of Print. Background:Timely diagnosis of structural heart disease improves patient outcomes, yet many remain underdiagnosed. While population screening with echocardiography is impractical, electrocardiogram (ECG)-based prediction models can help target high-risk patients. We (...) (Circulation)

6 May

Circulation http://ahajournals.org/

• 11:00
  E-Cigarette Use and Risk of Cardiovascular Disease: A Longitudinal Analysis of the PATH Study (2013–2019) - Jonathan B. Berlowitz Wubin Xie Alyssa F. Harlow Naomi M. Hamburg Michael J. Blaha Aruni Bhatnagar Emelia J. Benjamin Andrew C. Stokes Departments of Global Health (J.B.B., W.X., A.C.S.), Boston University School of Public Health, MA. Epidemiology (E.J.B.), Boston University School of Public Health, MA. University of Southern California Keck School of Medicine, Department of Population and Public Health Sciences, Los Angeles (A.F.H.). Department of Medicine, Boston University School of Medicine, MA (N.M.H., E.J.B.). Ciccarone Center for the Prevention of Cardiovascular Disease, Johns (...) Circulation
  Circulation, Volume 145, Issue 20, Page 1557-1559, May 17, 2022. (Circulation)

5 May

Circulation http://ahajournals.org/

• 11:00
  Efficacy and Safety of Dapagliflozin in Type 2 Diabetes According to Baseline Blood Pressure: Observations From DECLARE-TIMI 58 Trial - Remo H.M. Furtado Itamar Raz Erica L. Goodrich Sabina A. Murphy Deepak L. Bhatt Lawrence A. Leiter Darren K. McGuire John P.H. Wilding Philip Aylward Anthony J. Dalby Mikael Dellborg Doina Dimulescu José C. Nicolau Anthonius J.M. Oude Ophuis Avivit Cahn Ofri Mosenzon Ingrid Gause?Nilsson Anna Maria Langkilde Marc S. Sabatine Stephen D. Wiviott Academic Research Organization, Hospital Israelita Albert Einstein, Sao Paulo, Brazil; Instituto do Coracao (InCor), Hospital das Clinicas da Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil; TIMI Study Group, Division of (...) Circulation
  Circulation, Ahead of Print. Background:Dapagliflozin improved heart failure and kidney outcomes in patients with type 2 diabetes mellitus (T2DM) with or at high risk for cardiovascular disease in the DECLARE-TIMI 58 trial. Here, the aim was to analyze efficacy and safety of dapagliflozin (...) (Circulation)

4 May

Circulation http://ahajournals.org/

• 07:07
  First-Line Catheter Ablation of Monomorphic Ventricular Tachycardia in Cardiomyopathy Concurrent with Defibrillator Implantation: The PAUSE-SCD Randomized Trial - Roderick Tung Yumei Xue Minglong Chen Chenyang Jiang Dalise Y. Shatz Stephanie Besser Hongde Hu Fa-Po Chung Shiro Nakahara Young-Hoon Kim Kazuhiro Satomi Lishui Shen Erpeng Liang Hongtao Liao Kai Gu Ruhong Jiang Jian Jiang Yuichi Hori Jong-Il Choi Akiko Ueda Yuki Komatsu Shuichiro Kazawa Kyoko Soejima Shih-Ann Chen Akihiko Nogami Yan Yao The University of Chicago, Center for Arrhythmia Care, Pritzker School of Medicine, Chicago, IL; Guangdong Provincial People's Hospital, China; Department of Cardiology, Sir Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China (...) Circulation
  Circulation, Ahead of Print. Background:Catheter ablation as first-line therapy for ventricular tachycardia (VT) at the time of implantable cardioverter defibrillator (ICD) implantation has not been adopted into clinical guidelines. Also, there is an unmet clinical need to prospectively examine (...) (Circulation)

3 May

Circulation http://ahajournals.org/

• 11:00
  Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity - Raja Chakraborty Allison C. Ostriker Yi Xie Jui M. Dave Ana Gamez-Mendez Payel Chatterjee Yaw Abu Jake Valentine Kimberly Lezon-Geyda Daniel M. Greif Vincent P. Schulz Patrick G. Gallagher William C. Sessa John Hwa Kathleen A. Martin Department of Medicine (Cardiovascular Medicine), Yale University School of Medicine, New Haven, CT. (R.C., A.C.O., Y.X., J.M.D., P.C., Y.A., J.V., D.M.G., J.W., K.A.M) Department of Pharmacology, Yale University School of Medicine, New Haven, CT. (R.C., A.C.O., Y.X., A.G.-M., P.C., Y.A., J.V., W.C.S., K.A.M.) Department of Genetics, Yale University School of (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Vascular smooth muscle cell (VSMC) phenotypic switching contributes to cardiovascular diseases. Epigenetic regulation is emerging as a key regulatory mechanism, with the methylcytosine dioxygenase TET2 acting as a master regulator of smooth muscle cell (...) (Circulation)

2 May

Circulation http://ahajournals.org/

• 11:00
  Trends in Opioid Use After Cardiac Implantable Electronic Device Procedures in the United States Between 2004 and 2020 - Timothy M. Markman Emily Folse Lin Yang Peter W. Groeneveld David S. Frankel Cardiovascular Division (T.M.M., D.S.F.), University of Pennsylvania, Philadelphia. Division of General Internal Medicine (P.W.G.), Perelman School of Medicine; and Center for Cardiovascular Outcomes, Quality, Evaluative Research (T.M.M., L.Y., P.W.G., D.S.F.), University of Pennsylvania, Philadelphia. Thomas Jefferson University School of Medicine, Philadelphia, PA (E.F.). Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (...) Circulation
  Circulation, Volume 145, Issue 19, Page 1499-1501, May 10, 2022. (Circulation)
• 08:00
  ECG Challenge: Electric Extremis in a Critically Ill Patient - Royce Kim Jeffrey Kolominsky Kenneth A. Ellenbogen Division of Cardiology, Pauley Heart Center, Virginia Commonwealth University, Richmond. Circulation
  Circulation, Volume 145, Issue 18, Page 1431-1433, May 3, 2022. (Circulation)
• 08:00
  Border Disputes Between Heart Failure Phenotypes - Walter J. Paulus Amsterdam University Medical Centers, The Netherlands. Circulation
  Circulation, Volume 145, Issue 18, Page 1374-1376, May 3, 2022. (Circulation)
• 08:00
  Letter by Duan et al Regarding Article, “Therapeutic Exon Skipping Through a CRISPR-Guided Cytidine Deaminase Rescues Dystrophic Cardiomyopathy In Vivo” - Dongsheng Duan Kevin M. Flanigan Annemieke Aartsma-Rus Department of Molecular Microbiology and Immunology and Department of Neurology, School of Medicine; Department of Biomedical Sciences, College of Veterinary Medicine; and Department of Biomedical, Biological & Chemical Engineering, College of Engineering, University of Missouri, Columbia (D.D.). Center for Gene Therapy, Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH (K.M.F.). Department of Pediatrics, The Ohio State University College of Medicine, Columbus (K.M.F.). Department of Human Genetics, Leiden (...) Circulation
  Circulation, Volume 145, Issue 18, Page e872-e873, May 3, 2022. (Circulation)
• 08:00
  Response by Li and Chang Regarding Article, “Therapeutic Exon Skipping Through a CRISPR-Guided Cytidine Deaminase Rescues Dystrophic Cardiomyopathy In Vivo” - Jia Li Xing Chang Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou Zhejiang, China. Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China. Circulation
  Circulation, Volume 145, Issue 18, Page e874-e875, May 3, 2022. (Circulation)
• 08:00
  Single-Cell RNA Sequencing Reveals a Distinct Immune Landscape of Myeloid Cells in Coronary Culprit Plaques Causing Acute Coronary Syndrome - Takuo Emoto Hiroyuki Yamamoto Tomoya Yamashita Tomofumi Takaya Takahiro Sawada Shintaro Takeda Masayuki Taniguchi Naoto Sasaki Naofumi Yoshida Yoshihiro Saito Tharini Sivasubramaniyam Hiromasa Otake Tomoyuki Furuyashiki Clinton S. Robbins Hiroya Kawai Ken-ichi Hirata Division of Cardiovascular Medicine, Department of Internal Medicine (T.E., T.Y., S.T., N.Y., Y.S., H.O., K.H.), Kobe University Graduate School of Medicine, Japan. Division of Cardiovascular Medicine, Department of Exploratory and Advanced Search in Cardiology (T.T., H.K.), Kobe University Graduate School of Medicine, Japan. (...) Circulation
  Circulation, Volume 145, Issue 18, Page 1434-1436, May 3, 2022. (Circulation)
• 08:00
  Prevalence of Short-Coupled Ventricular Fibrillation in a Large Cohort of Dutch Patients With Idiopathic Ventricular Fibrillation - Sanne A. Groeneveld Martijn H. van der Ree Bart A. Mulder Jippe Balt Arthur A.M. Wilde Pieter G. Postema Rutger J. Hassink Department of Cardiology, University Medical Center Utrecht, The Netherlands (S.A.G., R.J.H.). Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Cardiovascular Sciences, The Netherlands (M.H.v.d.R., A.A.M.W., P.G.P.). Department of Cardiology, University Medical Center Groningen, The Netherlands (B.A.M.). Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands (...) Circulation
  Circulation, Volume 145, Issue 18, Page 1437-1439, May 3, 2022. (Circulation)
• 08:00
  Road to Equity in Brain Health - Mitchell S.V. Elkind Michelle A. Albert Donald M. Lloyd-Jones Department of Neurology, Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (M.S.V.E.). Department of Medicine, Division of Cardiology, Center for the Study of Adversity and Cardiovascular Disease (NURTURE Center), School of Medicine, University of California at San Francisco, San francisco, CA (M.A.A.). Departments of Preventive Medicine, Medicine, and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL (...) Circulation
  Circulation, Volume 145, Issue 18, Page e869-e871, May 3, 2022. (Circulation)
• 08:00
  Correction to: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines Circulation
  Circulation, Volume 145, Issue 18, Page e1033-e1033, May 3, 2022. (Circulation)
• 08:00
  Flexing Their Muscles: Maturation of Stem Cell–Derived Cardiomyocytes on Elastomeric Substrates to Enhance Cardiac Repair - Elaheh Karbassi Charles E. Murry Institute for Stem Cell and Regenerative Medicine, Center for Cardiovascular Biology, and Department of Laboratory Medicine & Pathology (E.K., C.E.M.), University of Washington, Seattle. Division of Cardiology, Department of Medicine (C.E.M.), University of Washington, Seattle. Department of Bioengineering (C.E.M.), University of Washington, Seattle. Sana Biotechnology, Seattle, WA (C.E.M.). Circulation
  Circulation, Volume 145, Issue 18, Page 1427-1430, May 3, 2022. (Circulation)

1 May

Circulation http://ahajournals.org/

• 11:00
  Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2–Deficient Hearts - Chantal J.M. van Opbergen Navratan Bagwan Svetlana R. Maurya Joon-Chul Kim Abigail N. Smith Daniel J. Blackwell Jeffrey N. Johnston Björn C. Knollmann Marina Cerrone, Alicia Lundby Mario Delmar The Leon Charney Division of Cardiology, New York University Grossmann School of Medicine (C.J.M.v.O., J.-C.K., M.C., M.D.). Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (N.B., S.R.M., A.L.). Department of Chemistry & Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN (A.N.S., J.N.J.). Vanderbilt Center for (...) Circulation
  Circulation, Volume 145, Issue 19, Page 1480-1496, May 10, 2022. Background:Exercise training, and catecholaminergic stimulation, increase the incidence of arrhythmic events in patients affected with arrhythmogenic right ventricular cardiomyopathy correlated with plakophilin-2 (PKP2) mutations. (...) (Circulation)

25 April

Circulation http://ahajournals.org/

• 11:00
  Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial - Axel C.P. Diederichsen Jes S. Lindholt Sören Möller Kristian A. Øvrehus Søren Auscher Jess Lambrechtsen Susanne E. Hosbond Dilek H. Alan Grazina Urbonaviciene Søren W. Becker Maise H. Fredgart Selma Hasific Lars Folkestad Oke Gerke Lars Melholt Rasmussen Jacob E. Møller Hans Mickley Jordi S. Dahl Department of Cardiology (A.C.P.D., K.A.Ø., M.H.F., S.H.‚ H.M., J.S.D.), Odense University Hospital, Denmark. Department of Cardiothoracic and Vascular Surgery (J.S.L.), Odense University Hospital, Denmark. Open Patient Data Explorative Network (S.M.), Odense University Hospital, Denmark. Department of (...) Circulation
  Circulation, Volume 145, Issue 18, Page 1387-1397, May 3, 2022. Background:Menaquinone-7 (MK-7), also known as vitamin K2, is a cofactor for the carboxylation of proteins involved in the inhibition of arterial calcification and has been suggested to reduce the progression rate of aortic valve (...) (Circulation)
• 08:00
  The Social Robots Are Coming: Preparing for a New Wave of Virtual Care in Cardiovascular Medicine - Karen Bouchard Peter P. Liu Heather Tulloch University of Ottawa Heart Institute, Canada (K.B., P.P.L., H.T.). University of Ottawa, Canada (K.B., P.P.L., H.T.). Circulation
  Circulation, Volume 145, Issue 17, Page 1291-1293, April 26, 2022. (Circulation)
• 08:00
  Letter by Dhruva and Redberg Regarding Article, “Amplatzer Amulet Left Atrial Appendage Occluder Versus Watchman Device for Stroke Prophylaxis (Amulet IDE): A Randomized, Controlled Trial” - Sanket S. Dhruva Rita F. Redberg Philip R. Lee Institute for Health Policy Studies (S.S.D., R.F.R.) University of California, San Francisco. Section of Cardiology, Department of Medicine, San Francisco Veterans Affairs Medical Center, CA (S.S.D.). Department of Medicine, Division of Cardiology (R.F.R.), University of California, San Francisco School of Medicine, San Francisco. Circulation
  Circulation, Volume 145, Issue 17, Page e845-e846, April 26, 2022. (Circulation)
• 08:00
  Fast and Furious: A Case of Group Beating and Cardiomyopathy - Salwa Rahman Angelo Biviano Hirad Yarmohammadi Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York. Circulation
  Circulation, Volume 145, Issue 17, Page 1364-1366, April 26, 2022. (Circulation)
• 08:00
  Letter by Natale et al Regarding Article, “Amplatzer Amulet Left Atrial Appendage Occluder Versus Watchman Device for Stroke Prophylaxis (Amulet IDE): A Randomized, Controlled Trial” - Andrea Natale Saibal Kar David Holmes Texas Cardiac Arrythmia Institute, Austin, TX (A.N.). Los Robles Regional Medical Center, Thousand Oaks, CA (S.K.). Mayo Clinic, Rochester, MN (D.H.). Circulation
  Circulation, Volume 145, Issue 17, Page e847-e848, April 26, 2022. (Circulation)
• 08:00
  Letter by Price et al Regarding the Article, “Amplatzer Amulet Left Atrial Appendage Occluder Versus Watchman Device for Stroke Prophylaxis (Amulet IDE): A Randomized, Controlled Trial” - Matthew J. Price Doug N. Gibson Saibal Kar Division of Cardiovascular Diseases, Scripps Clinic, La Jolla, CA (M.J.P., D.NG.). Los Robles Regional Medical Center, Thousand Oaks, CA (S.K.). Circulation
  Circulation, Volume 145, Issue 17, Page e849-e849, April 26, 2022. (Circulation)
• 08:00
  Response by Lakireddy et al to Letters Regarding Article, “Amplatzer Amulet Left Atrial Appendage Occluder Versus Watchman Device for Stroke Prophylaxis (Amulet IDE): A Randomized, Controlled Trial” - Dhanunjaya Lakkireddy David Thaler Stephan Windecker Kansas City Heart Rhythm Institute and Research Foundation, Overland Park, KS (D.L.). Tufts Medical Center, Boston, MA (D.T.). Inselspital, University of Bern, Switzerland (S.W). Circulation
  Circulation, Volume 145, Issue 17, Page e850-e851, April 26, 2022. (Circulation)
• 08:00
  Modeling Effects of Immunosuppressive Drugs on Human Hearts Using Induced Pluripotent Stem Cell–Derived Cardiac Organoids and Single-Cell RNA Sequencing - Karim Sallam Dilip Thomas Sadhana Gaddam Nicole Lopez Aimee Beck Leila Beach Albert J. Rogers Hao Zhang Ian Y. Chen Mohamed Ameen William Hiesinger Jeffrey J. Teuteberg June-Wha Rhee Kevin C. Wang Nazish Sayed Joseph C. Wu Stanford Cardiovascular Institute (K.S., D.T., N.L., A.B., A.J.R., H.Z., I.Y.C., M.A., J.-W.R., N.S., J.C.W.), Stanford University School of Medicine, CA. Division of Cardiovascular Medicine, Department of Medicine (K.S., L.B., A.J.R., I.Y.C., J.J.T., J.-W.R., J.C.W.), Stanford University School of Medicine, CA. Department of Cardiothoracic Surgery (W.H.), Stanford (...) Circulation
  Circulation, Volume 145, Issue 17, Page 1367-1369, April 26, 2022. (Circulation)
• 08:00
  Correction to: Prevention of Viridans Group Streptococcal Infective Endocarditis: A Scientific Statement From the American Heart Association Circulation
  Circulation, Volume 145, Issue 17, Page e868-e868, April 26, 2022. (Circulation)
• 08:00
  Improving Symptoms and Quality of Life in Stable Coronary Artery Disease: An Evolving Paradigm - Krishna K. Patel Icahn School of Medicine at Mount Sinai, New York. Circulation
  Circulation, Volume 145, Issue 17, Page 1308-1311, April 26, 2022. (Circulation)
• 08:00
  At the Brink of Human Therapy to Generate New Myocytes in the Adult Injured Heart - Vikram Prasad Jeffery D. Molkentin Cincinnati Children’s Hospital Medical Center, University of Cincinnati, OH. Circulation
  Circulation, Volume 145, Issue 17, Page 1356-1358, April 26, 2022. (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 145, Issue 17, Page 1359-1363, April 26, 2022. (Circulation)

22 April

Circulation http://ahajournals.org/

• 11:00
  Hourly Air Pollutants and Acute Coronary Syndrome Onset In 1.29 Million Patients - Renjie Chen Yixuan Jiang Jialu Hu Honglei Chen Huichu Li Xia Meng John S. Ji Ya Gao Weidong Wang Cong Liu Weiyi Fang Hongbing Yan Jiyan Chen Weiman Wang Dingcheng Xiang Xi Su Bo Yu Yan Wang Yawei Xu Lefeng Wang Chunjie Li Yundai Chen Michelle L. Bell Aaron J. Cohen Junbo Ge Yong Huo Haidong Kan School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China Department of Epidemiology and Biostatistics, (...) Circulation
  Circulation, Ahead of Print. Background:Short-term exposure to ambient air pollution has been linked with daily hospitalization and mortality of acute coronary syndrome (ACS); however, the associations of sub-daily (hourly) levels of criteria air pollutants with the onset of ACS and its (...) (Circulation)

20 April

Circulation http://ahajournals.org/

• 05:56
  Initial Decline ("dip") in Estimated Glomerular Filtration Rate Following Initiation of Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction: Insights from DAPA-HF. - Carly Adamson Kieran F. Docherty Hiddo J.L. Heerspink Rudolf A. de Boer Kevin Damman Silvio E Inzucchi Lars Køber Mikhail N. Kosiborod Felipe A. Martinez Mark C. Petrie Piotr Ponikowski Marc S. Sabatine Morten Schou Scott D. Solomon Subodh Verma Olof Bengtsson Anna Maria Langkilde Mikaela Sjöstrand Muthiah Vaduganathan Pardeep S. Jhund John J.V. McMurray BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands University of (...) Circulation
  Circulation, Ahead of Print. Background:In a post hoc analysis, the frequency of occurrence of an early decline ("dip") in estimated glomerular filtration rate (eGFR) after initiation of dapagliflozin, and its association with outcomes, was evaluated in patients with heart failure and reduced (...) (Circulation)

19 April

Circulation http://ahajournals.org/

• 11:00
  Progressive Reduction in Right Ventricular Contractile Function Due to Altered Actin Expression in an Aging Mouse Model of Arrhythmogenic Cardiomyopathy - Emmanuel M. Camors Alyson H. Roth Joseph R. Alef Ryan D. Sullivan Jason N Johnson Enkhsaikhan Purevjav Jeffrey A. Towbin Heart Institute, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN Department of Internal Medicine, University of Arizona College of Medicine, Phoenix, AR Heart Institute, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN; (...) Circulation
  Circulation, Ahead of Print. Background: Arrhythmogenic cardiomyopathy (ACM) is an inherited genetic disorder of desmosomal dysfunction, and plakophilin-2 (PKP2) has been reported to be the most common disease-causing gene when mutation-positive. In the early “concealed” phase, the ACM heart is (...) (Circulation)

18 April

Circulation http://ahajournals.org/

• 11:00
  Cardiac Resident Macrophage-Derived Legumain Improves Cardiac Repair by Promoting Clearance and Degradation of Apoptotic Cardiomyocytes After Myocardial Infarction - Daile Jia Siqin Chen Peiyuan Bai Chentao Luo Jin Liu Aijun Sun Junbo Ge Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, China (D.J., P.B., J.L., A.S., J.G.). Key Laboratory of Viral Heart Diseases, National Health Commission, Shanghai, China (D.J., S.C., P.B., J.L., A.S., J.G.). Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China (D.J., S.C., P.B., J.L., A.S., J.G.). Institutes of Biomedical Sciences, Fudan University, Shanghai, China (S.C., A.S., J.G.). Department of Cardiovascular (...) Circulation
  Circulation, Volume 145, Issue 20, Page 1542-1556, May 17, 2022. Background:Cardiac resident macrophages are self-maintaining and originate from embryonic hematopoiesis. After myocardial infarction, cardiac resident macrophages are responsible for the efficient clearance and degradation of (...) (Circulation)
• 11:01
  Temporal Trends in the Remaining Lifetime Risk of Cardiovascular Disease Among Middle-Aged Adults Across 6 Decades: The Framingham Study - Ramachandran S. Vasan Danielle M. Enserro Vanessa Xanthakis Alexa S. Beiser Sudha Seshadri Boston University and the National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, MA (R.S.V., V.X., A.S.B., S.S.). Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, MA (R.S.V., V.X.). Department of Epidemiology (R.S.V.), Boston University School of Public Health, MA. Department of Biostatistics (V.X., A.S.B.), Boston University School of Public Health, MA. NRG Oncology and Clinical Trials Development Division, (...) Circulation
  Circulation, Volume 145, Issue 17, Page 1324-1338, April 26, 2022. Background:The remaining lifetime risk (RLR) is the probability of developing an outcome over the remainder of one’s lifespan at any given age. The RLR for atherosclerotic cardiovascular disease (ASCVD) in three 20-year periods (...) (Circulation)
• 08:00
  Letter by Gronda et al Regarding Article, “Effect of Empagliflozin on Worsening Heart Failure Events in Patients With Heart Failure and Preserved Ejection Fraction: EMPEROR-Preserved Trial” - Edoardo Gronda Furio Colivicchi Giuseppe Zuccalà UOC di Nefrolo- gia, Dialisi e Trapianto Renale dell’Adulto, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico. Milan, Italy (E.G.). Azienda Complesso Ospedaliero San Filippo Neri, Rome, Italy (F.C.). Cardiologia Clinica e Riabilitativa, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy (G.Z.). Circulation
  Circulation, Volume 145, Issue 16, Page e839-e840, April 19, 2022. (Circulation)
• 08:00
  Sinus Node Dysfunction With a Nice Twist - Aviram Hochstadt Raphael Rosso Sami Viskin Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, Israel. Circulation
  Circulation, Volume 145, Issue 16, Page 1285-1287, April 19, 2022. (Circulation)
• 08:00
  Percutaneous Transvalvular Microaxial Flow Pump Support in Cardiology - Enzo Lüsebrink Antonia Kellnar Kathrin Krieg Leonhard Binzenhöfer Clemens Scherer Sebastian Zimmer Benedikt Schrage Stephanie Fichtner Tobias Petzold Daniel Braun Sven Peterss Stefan Brunner Christian Hagl Dirk Westermann Jörg Hausleiter Steffen Massberg Holger Thiele Andreas Schäfer Martin Orban Cardiac Intensive Care Unit, Medizinische Klinik und Poliklinik I (E.L., A.K., K.K., L.B., C.S., S.F., T.P., D.B., S.B., J.H., S.M., M.O.), Klinikum der Universität München, and German Center for Cardiovascular Research, partner site Munich Heart Alliance. Herzchirurgische Klinik und Poliklinik (S.P., (...) Circulation
  Circulation, Volume 145, Issue 16, Page 1254-1284, April 19, 2022. The Impella device (Impella, Abiomed, Danvers, MA) is a percutaneous transvalvular microaxial flow pump that is currently used for (1) cardiogenic shock, (2) left ventricular unloading (combination of venoarterial extracorporeal (...) (Circulation)
• 08:00
  Price and Quality in the Generic Pharmaceutical Market - Ben Teasdale David Light Kevin A. Schulman Clinical Excellence Research Center, School of Medicine (B.T., K.A.S.), Stanford University, Palo Alto, CA. Graduate School of Business (K.A.S.), Stanford University, Palo Alto, CA. Valisure, LLC, New Haven, CT (D.L.). Circulation
  Circulation, Volume 145, Issue 16, Page 1185-1187, April 19, 2022. (Circulation)
• 08:00
  Correction to: Coronary Artery and Cardiac Disease in Patients With Type 2 Myocardial Infarction: A Prospective Cohort Study Circulation
  Circulation, Volume 145, Issue 16, Page e841-e841, April 19, 2022. (Circulation)
• 08:00
  Correction to: Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration Circulation
  Circulation, Volume 145, Issue 16, Page e842-e842, April 19, 2022. (Circulation)
• 08:00
  Correction to: Protein Kinase C? Via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6Chi Cells Contributes to Atherosclerosis Circulation
  Circulation, Volume 145, Issue 16, Page e843-e843, April 19, 2022. (Circulation)
• 08:00
  Correction to: Impact of S-Adenosylmethionine Decarboxylase 1 on Pulmonary Vascular Remodeling Circulation
  Circulation, Volume 145, Issue 16, Page e844-e844, April 19, 2022. (Circulation)
• 08:00
  Zooming in on the Enigmas of Type 2 Myocardial Infarction - Harvey D. White Green Lane Cardiovascular Department, Auckland City Hospital and Auckland University, New Zealand. Circulation
  Circulation, Volume 145, Issue 16, Page 1201-1204, April 19, 2022. (Circulation)
• 08:00
  Exercise-Induced Long Noncoding RNAs As New Players in Cardiac Hypertrophy - Catherine A. Makarewich Thomas Thum The Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children’s Hospital Medical Center, OH (C.A.M.). Department of Pediatrics, University of Cincinnati College of Medicine, OH (C.A.M.). Institute of Molecular and Translational Therapeutic Strategies; REBIRTH Center for Translational Regenerative Medicine, Hannover Medical School; and Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany (...) Circulation
  Circulation, Volume 145, Issue 16, Page 1234-1237, April 19, 2022. (Circulation)

15 April

Circulation http://ahajournals.org/

• 11:00
  Deep Lipidomics in Human Plasma - Cardiometabolic Disease Risk and Effect of Dietary Fat Modulation - Fabian Eichelmann Laury Sellem Clemens Wittenbecher Susanne Jäger Olga Kuxhaus Marcela Prada Rafael Cuadrat Kim G. Jackson Julie A. Lovegrove Matthias B. Schulze Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany Hugh Sinclair Unit of Human Nutrition, and Institute for Cardiovascular and Metabolic Research, Department of Food and Nutritional Science, University of Reading, Whiteknights, Pepper Lane, Harry Nursten Building, Reading, UK Department of Molecular (...) Circulation
  Circulation, Ahead of Print. Background:In blood and tissues, dietary and endogenously generated fatty acids (FAs) occur in free form or as part of complex lipid molecules that collectively represent the lipidome of the respective tissue. We assessed associations of plasma lipids derived from (...) (Circulation)

11 April

Circulation http://ahajournals.org/

• 11:01
  SARS-CoV-2 Infection and Associated Cardiovascular Manifestations and Complications in Children and Young Adults: A Scientific Statement From the American Heart Association - Pei-Ni Jone Anitha John Matthew E. Oster Kiona Allen Adrianna H. Tremoulet Elizabeth V. Saarel Linda M. Lambert Shelley D. Miyamoto Sarah D. de Ferranti Circulation
  Circulation, Volume 145, Issue 19, Page e1037-e1052, May 10, 2022. Coronavirus disease 2019 (COVID-19) resulted in a global pandemic and has overwhelmed health care systems worldwide. In this scientific statement, we describe the epidemiology, pathophysiology, clinical presentations, treatment, (...) (Circulation)
• 11:37
  Computational Analysis of Routine Biopsies Improves Diagnosis and Prediction of Cardiac Allograft Vasculopathy - Eliot G. Peyster Andrew Janowczyk Abigail Swamidoss Samhith Kethireddy Michael D. Feldman Kenneth B. Margulies Cardiovascular Research Institute, University of Pennsylvania, Philadelphia, PA Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH; Department of Oncology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, (...) Circulation
  Circulation, Ahead of Print. Background:Cardiac allograft vasculopathy (CAV) is a leading cause of morbidity and mortality for heart transplant recipients. While clinical risk factors for CAV have been established, no personalized prognostic test exists to confidently identify patients at high (...) (Circulation)
• 11:00
  Rewiring of 3D Chromatin Topology Orchestrates Transcriptional Reprogramming and the Development of Human Dilated Cardiomyopathy - Yuliang Feng Liuyang Cai Wanzi Hong Chunxiang Zhang Ning Tan Mingyang Wang Cheng Wang Feng Liu Xiaohong Wang Jianyong Ma Chen Gao Mohit Kumar Yuanxi Mo Qingshan Geng Changjun Luo Yan Lin Haiyang Chen Shuang-Yin Wang Michael J. Watson Anil G. Jegga Roger A. Pedersen Ji-dong Fu Zhao V. Wang Guo-Chang Fan Sakthivel Sadayappan Yigang Wang Siim Pauklin Feng Huang Wei Huang Lei Jiang Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford Old Road, Headington, Oxford, UK Department of Microbiology, Faculty of Medicine, The (...) Circulation
  Circulation, Ahead of Print. Background:Transcriptional reconfiguration is central to heart failure, the common cause of which is dilated cardiomyopathy (DCM). However, the impact of three-dimensional (3D) chromatin topology on transcriptional dysregulation and pathogenesis in human DCM remains (...) (Circulation)
• 08:00
  Prevalence, Characteristics, and Outcomes of COVID-19–Associated Acute Myocarditis - Enrico Ammirati Laura Lupi Matteo Palazzini Nicholas S. Hendren Justin L. Grodin Carlo V. Cannistraci Matthieu Schmidt Guillaume Hekimian Giovanni Peretto Thomas Bochaton Ahmad Hayek Nicolas Piriou Sergio Leonardi Stefania Guida Annalisa Turco Simone Sala Aitor Uribarri Caroline M. Van de Heyning Massimo Mapelli Jeness Campodonico Patrizia Pedrotti Maria Isabel Barrionuevo Sánchez Albert Ariza Sole Marco Marini Maria Vittoria Matassini Mickael Vourc’h Antonio Cannatà Daniel I. Bromage Daniele Briguglia Jorge Salamanca Pablo Diez-Villanueva Jukka Lehtonen Florent Huang Stéphanie Russel (...) Circulation
  Circulation, Volume 145, Issue 15, Page 1123-1139, April 12, 2022. Background:Acute myocarditis (AM) is thought to be a rare cardiovascular complication of COVID-19, although minimal data are available beyond case reports. We aim to report the prevalence, baseline characteristics, in-hospital (...) (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 145, Issue 15, Page 1169-1174, April 12, 2022. (Circulation)
• 08:00
  Unrepairable Infant Mitral Valve: An Unexpected Case of Decompensated Heart Failure - Alexander K. Reed Peter Chiu Chrystalle Katte Carreon Stephen P. Sanders Pedro J. del Nido Christopher W. Baird Harvard Medical School, Boston, MA (A.K.R.). Department of Cardiac Surgery (P.C., P.J.d.N., C.W.B.), Boston Children’s Hospital/Harvard Medical School, MA. Department of Pathology (C.K.C., S.P.S.), Boston Children’s Hospital/Harvard Medical School, MA. Cardiac Registry, Departments of Cardiology, Pathology, and Cardiac Surgery, Boston Children’s Hospital, MA (C.K.C., (...) Circulation
  Circulation, Volume 145, Issue 15, Page 1175-1178, April 12, 2022. (Circulation)
• 08:00
  Prioritizing Quad Therapy and the Path Forward in Guideline-Directed Medical Therapy for Patients With Heart Failure With Reduced Ejection Fraction - Josephine Harrington Robert J. Mentz Duke University School of Medicine (J.H., R.J.M.), Durham, NC. Duke Clinical Research Institute (J.H., R.J.M.), Durham, NC. Circulation
  Circulation, Volume 145, Issue 15, Page 1105-1107, April 12, 2022. (Circulation)
• 08:00
  Letter by Trimaille et al Regarding Article, “Native Aortic Valve Disease Progression and Bioprosthetic Valve Degeneration in Patients With Transcatheter Aortic Valve Implantation” - Antonin Trimaille Sandy Hmadeh Olivier Morel Department of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, France (A.T., O.M.). Institut National de la Santé Et de la Recherche Médicale (French National Institute of Health and Medical Research), Unité Mixte de Recherche 1260, Regenerative Nanomedicine, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France (A.T., S.H., O.M.). Circulation
  Circulation, Volume 145, Issue 15, Page e807-e808, April 12, 2022. (Circulation)
• 08:00
  Response by Kwiecinski et al to Letter Regarding Article, “Native Aortic Valve Disease Progression and Bioprosthetic Valve Degeneration in Patients With Transcatheter Aortic Valve Implantation” - Jacek Kwiecinski Evangelos Tzolos Rong Bing Marc R. Dweck Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.). Centre for Cardiovascular Science, University of Edinburgh, UK (E.T., R.B., M.R.D.). Circulation
  Circulation, Volume 145, Issue 15, Page e809-e810, April 12, 2022. (Circulation)
• 08:00
  Dual Genetic Lineage Tracing Reveals Capillary to Artery Formation in the Adult Heart - Maoying Han Zixin Liu Lingjuan He Xufeng Li Lei Liu Xiuzhen Huang Mingjun Zhang Yan Yan Kathy O. Lui Bin Zhou The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (M.H., Z.L., X.H., M.Z., B.Z.), University of Chinese Academy of Sciences, Shanghai, China. School of Life Science, Hangzhou Institute for Advanced Study (X.L., B.Z.), University of Chinese Academy of Sciences, Shanghai, China. Science and Technology, ShanghaiTech University, China (M.H., L.L., B.Z.). School (...) Circulation
  Circulation, Volume 145, Issue 15, Page 1179-1181, April 12, 2022. (Circulation)
• 08:00
  In Utero Brain Growth Matters for Fetuses With Congenital Heart Disease - Mike Seed Catherine Limperopoulos Department of Paediatrics, Hospital for Sick Children, University of Toronto, Canada (M.S.). Department of Pediatrics, George Washington University School of Medicine, Washington, DC (C.L.). Circulation
  Circulation, Volume 145, Issue 15, Page 1120-1122, April 12, 2022. (Circulation)

8 April

Circulation http://ahajournals.org/

• 08:08
  Sodium-Glucose Cotransporter 2 Inhibitors and Risk of Hyperkalemia in People With Type 2 Diabetes: A Meta-Analysis of Individual Participant Data From Randomized, Controlled Trials - Brendon L. Neuen Megumi Oshima Rajiv Agarwal Clare Arnott David Z. Cherney Robert Edwards Anna Maria Langkilde Kenneth W. Mahaffey Darren K. McGuire Bruce Neal Vlado Perkovic Annpey Pong Marc S. Sabatine Itamar Raz Tadashi Toyama Christoph Wanner David C. Wheeler Stephen D. Wiviott Bernard Zinman Hiddo J.L. Heerspink The George Institute for Global Health, University of New South Wales, Sydney, Australia (B.L.N., C.A.). Department of Nephrology and Laboratory Medicine, Kanazawa University, Japan (M.O., T.T.). Indiana University School of Medicine and VA Medical Center, Indianapolis (...) Circulation
  Circulation, Volume 145, Issue 19, Page 1460-1470, May 10, 2022. Background:Hyperkalemia increases risk of cardiac arrhythmias and death and limits the use of renin-angiotensin-aldosterone system inhibitors and mineralocorticoid receptor antagonists, which improve clinical outcomes in people (...) (Circulation)

7 April

Circulation http://ahajournals.org/

• 07:00
  Monogenic and Polygenic Contributions to QTc Prolongation in the Population - Victor Nauffal Valerie N. Morrill Sean J. Jurgens Seung Hoan Choi Amelia W. Hall Lu-Chen Weng Jennifer L. Halford Christina Austin-Tse Christopher M. Haggerty Stephanie L. Harris Eugene K. Wong Alvaro Alonso Dan E. Arking Emelia J. Benjamin Eric Boerwinkle Yuan-I Min Adolfo Correa Brandon K. Fornwalt Susan R. Heckbert Charles Kooperberg Henry J. Lin Ruth J.F. Loos Kenneth M. Rice Namrata Gupta Thomas W. Blackwell Braxton D. Mitchell Alanna C. Morrison Bruce M. Psaty Wendy S. Post Susan Redline Heidi L. Rehm Stephen S. Rich Jerome I. Rotter Elsayed Z. Soliman Nona Sotoodehnia Kathryn L. (...) Circulation
  Circulation, Volume 145, Issue 20, Page 1524-1533, May 17, 2022. Background:Rare sequence variation in genes underlying cardiac repolarization and common polygenic variation influence QT interval duration. However, current clinical genetic testing of individuals with unexplained QT prolongation (...) (Circulation)
• 05:46
  Association of Bleeding Severity With Mortality in Extended Thromboprophylaxis of Medically Ill Patients in the MAGELLAN and MARINER Trials - Alex C. Spyropoulos Gary E. Raskob Alexander T. Cohen Walter Ageno Jeffrey I. Weitz Theodore E. Spiro Wentao Lu Concetta Lipardi Gregory W. Albers C. Gregory Elliott Jonathan L. Halperin William R. Hiatt Gregory Maynard P. Gabriel Steg Chiara Sugarmann Elliot S. Barnathan Feinstein Institute for Medical Research, Department of Medicine, Anticoagulation and Clinical Thrombosis Services Northwell Health at Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York (A.C.S.). Hudson College of Public Health, University of Oklahoma Health Sciences Center, (...) Circulation
  Circulation, Volume 145, Issue 19, Page 1471-1479, May 10, 2022. Background:Extended thromboprophylaxis has not been widely implemented in acutely ill medical patients because of bleeding concerns. The MAGELLAN (Multicenter, Randomized, Parallel Group Efficacy and Safety Study for the (...) (Circulation)
• 11:00
  Genetic Landscape of the ACE2 Coronavirus Receptor - Zhijian Yang Erin Macdonald-Dunlop Jiantao Chen Ranran Zhai Ting Li Anne Richmond Lucija Klari? Nicola Pirastu Zheng Ning Chenqing Zheng Yipeng Wang Tingting Huang Yazhou He Huiming Guo Kejun Ying Stefan Gustafsson Bram Prins Anna Ramisch Emmanouil T. Dermitzakis Grace Png Niclas Eriksson Jeffrey Haessler Xiaowei Hu Daniela Zanetti Thibaud Boutin Shih-Jen Hwang Eleanor Wheeler Maik Pietzner Laura M. Raffield Anette Kalnapenkis James E. Peters Ana Viñuela Arthur Gilly Sölve Elmståhl George Dedoussis John R. Petrie Ozren Polašek Lasse Folkersen Yan Chen Chen Yao Urmo Võsa Erola Pairo-Castineira (...) Circulation
  Circulation, Volume 145, Issue 18, Page 1398-1411, May 3, 2022. Background:SARS-CoV-2, the causal agent of COVID-19, enters human cells using the ACE2 (angiotensin-converting enzyme 2) protein as a receptor. ACE2 is thus key to the infection and treatment of the coronavirus. ACE2 is highly (...) (Circulation)
• 10:10
  Skeletal Muscle Disorders: A Non-cardiac Source of Cardiac Troponin T - Jeanne du Fay de Lavallaz Alexandra Prepoudis Maria Janina Wendebourg Eva Kesenheimer Diego Kyburz Thomas Daikeler Philip Haaf Julia Wanschitz Wolfgang N. Löscher Bettina Schreiner Mira Katan Hans H. Jung Britta Maurer Angelika Hammerer-Lercher Agnes Mayr Danielle M. Gualandro Annemarie Acket Christian Puelacher Jasper Boeddinghaus Thomas Nestelberger Pedro Lopez-Ayala Noemi Glarner Samyut Shrestha Robert Manka Joanna Gawinecka Salvatore Piscuoglio John Gallon Sophia Wiedemann Michael Sinnreich Christian Mueller Cardiovascular Research Institute Basel and Department of Cardiology, (...) Circulation
  Circulation, Ahead of Print. Background:Cardiac troponin T (cTnT) and cTnI are considered cardiac-specific and equivalent in the diagnosis of acute myocardial infarction. Previous studies suggested rare skeletal myopathies as a non-cardiac source of cTnT. We aimed to confirm the (...) (Circulation)

6 April

Circulation http://ahajournals.org/

• 04:05
  Muscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy - Muhammad Riaz Jinkyu Park Lorenzo R. Sewanan Yongming Ren Jonas Schwan Subhash K. Das Pawel T. Pomianowski Yan Huang Matthew W. Ellis Jiesi Luo Juli Liu Loujin Song I-Ping Chen Caihong Qiu Masayuki Yazawa George Tellides John Hwa Lawrence H. Young Lei Yang Charles C. Marboe Daniel L. Jacoby Stuart G. Campbell Yibing Qyang Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine (M.R., J.P., Y.R., S.K.D., Y.H., M.W.E., J. Luo, J.H., L.H.Y., D.L.J., Y.Q.), Yale University School of Medicine, New Haven, CT. Department of Pathology (M.R., J.P., (...) Circulation
  Circulation, Volume 145, Issue 16, Page 1238-1253, April 19, 2022. Background:Familial hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease and is typically caused by mutations in genes encoding sarcomeric proteins that regulate cardiac contractility. HCM (...) (Circulation)

4 April

Circulation http://ahajournals.org/

• 14:30
  Edoxaban versus Dual Antiplatelet Therapy for Leaflet Thrombosis and Cerebral Thromboembolism after TAVR: The ADAPT-TAVR Randomized Clinical Trial - Duk-Woo Park Jung-Min Ahn Do-Yoon Kang Kyung Won Kim Hyun Jung Koo Dong Hyun Yang Seung Chai Jung Byungjun Kim Yiu Tung Anthony Wong Cheung Chi Simon Lam Wei-Hsian Yin Jeng Wei Yung-Tsai Lee Hsien-Li Kao Mao-Shin Lin Tsung-Yu Ko Won-Jang Kim Se Hun Kang Sung-Cheol Yun Seung-Ah Lee Euihong Ko Hanbit Park Dae-Hee Kim Joon-Won Kang Jae-Hong Lee Seung-Jung Park Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Asan Image Metrics, Clinical Trial Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea Department of Radiology (...) Circulation
  Circulation, Ahead of Print. Background:It is unknown whether direct oral anticoagulant edoxaban can reduce leaflet thrombosis and the accompanying cerebral thromboembolic risk after transcatheter aortic-valve replacement (TAVR). Also, the causal relationship of subclinical leaflet thrombosis (...) (Circulation)
• 08:00
  Fishing for Links Between Omega-3 Fatty Acids and Atrial Fibrillation - Diane Fatkin Charles D. Cox Boris Martinac Victor Chang Cardiac Research Institute, Darlinghurst, Australia (D.F., C.D.C., B.M.). St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Sydney, Kensington, Australia (D.F., C.D.C., B.M.). Cardiology Department, St Vincent’s Hospital, Darlinghurst, Australia (D.F.). Circulation
  Circulation, Volume 145, Issue 14, Page 1037-1039, April 5, 2022. (Circulation)
• 08:00
  Letter by Belmadani and Matrougui Regarding Article, “Integrated Stress Response Couples Mitochondrial Protein Translation With Oxidative Stress Control” - Souad Belmadani Khalid Matrougui Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk. Circulation
  Circulation, Volume 145, Issue 14, Page e802-e803, April 5, 2022. (Circulation)
• 08:00
  Response by Zhang and Wang to Letter Regarding Article, “Integrated Stress Response Couples Mitochondrial Protein Translation With Oxidative Stress Control” - Guangyu Zhang Zhao V. Wang Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA. Circulation
  Circulation, Volume 145, Issue 14, Page e804-e805, April 5, 2022. (Circulation)
• 08:00
  Identification of DNA Damage Repair Enzyme Ascc2 as Causal for Heart Failure With Preserved Ejection Fraction - Yang Cao Calvin Pan Yu-Chen Wang Zhiqiang Zhou Vida Jedian Yonghong Meng Gillian Campbell Kristina Guardino Christopher Li Jessica Wang Aldons J. Lusis Department of Medicine, Division of Cardiology (Y.C., C.P., Y.-C.W., Z.Z., V.J., Y.M., J.W., A.J.L.), University of California, Los Angeles Human Genetics (A.J.L.), University of California, Los Angeles Microbiology, Immunology, and Molecular Genetics (G.C., K.G., C.L., A.J.L.), University of California, Los (...) Circulation
  Circulation, Volume 145, Issue 14, Page 1102-1104, April 5, 2022. (Circulation)
• 08:00
  Correction to: Shaping Value-Based Payment Policy: Improving Heart Health Through Value-Based Payment Circulation
  Circulation, Volume 145, Issue 14, Page e806-e806, April 5, 2022. (Circulation)
• 08:00
  What Turns the White Matter White? Metabolomic Clues to the Origin of Age-Related Cerebral White Matter Hyperintensities - Eric E. Smith Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. Circulation
  Circulation, Volume 145, Issue 14, Page 1053-1055, April 5, 2022. (Circulation)
• 06:45
  Effects of Empagliflozin on Symptoms, Physical Limitations and Quality of Life in Patients Hospitalized for Acute Heart Failure - Results From the EMPULSE Trial - Mikhail N. Kosiborod Christiane E Angermann Sean P. Collins John R. Teerlink Piotr Ponikowski Jan Biegus Josep Comin-Colet João Pedro Ferreira Robert J. Mentz Michael E. Nassif Mitchell A. Psotka Jasper Tromp Martina Brueckmann Jonathan P. Blatchford Afshin Salsali Adriaan A. Voors Saint Luke's Mid America Heart Institute, Kansas City, MO; School of Medicine, University of Missouri-Kansas City, Kansas City, MO; The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia Comprehensive Heart Failure Centre, University and University Hospital of (...) Circulation
  Circulation, Ahead of Print. Background:Patients hospitalized for acute heart failure (AHF) experience poor health status, including high burden of symptoms and physical limitations, and poor quality of life. Sodium-glucose cotransporter 2 (SGLT2) inhibitors improve health status in chronic HF, (...) (Circulation)
• 05:00
  A Randomized Trial of Chocolate Touch Compared with Lutonix Drug-Coated Balloon in Femoropopliteal Lesions (The CHOCOLATE TOUCH Study) - Mehdi H. Shishehbor Thomas Zeller Martin Werner Marianne Brodmann Helen Parise Andrew Holden Michael Lichtenberg Sahil A. Parikh Vikram S. Kashyap Cody Pietras Daniela Tirziu Shiva Ardakani Ulrich Beschorner Prakash Krishnan Khusrow A. Niazi Andreas U. Wali Alexandra J. Lansky University Hospitals Harrington Heart and Vascular Institute, Cleveland, OH University Heart Center Freiburg, Bad Krozingen, Germany Department of Angiology, Hanusch Hospital, Vienna, Austria Medical University of Graz, Graz, Austria Yale University School of Medicine, New Haven, CT Auckland City Hospital, Auckland, (...) Circulation
  Circulation, Ahead of Print. Background: First-generation drug-coated balloons (DCBs) have significantly reduced the rate of restenosis compared with balloon angioplasty alone; however, high rates of bailout stenting and dissections persist. The Chocolate Touch DCB is a nitinol constrained (...) (Circulation)

3 April

Circulation http://ahajournals.org/

• 14:00
  Effect of Vupanorsen on Non–High-Density Lipoprotein Cholesterol Levels in Statin-Treated Patients With Elevated Cholesterol: TRANSLATE-TIMI 70 - Brian A. Bergmark Nicholas A. Marston Candace R. Bramson Madelyn Curto Vesper Ramos Alexandra Jevne Julia F. Kuder Jeong-Gun Park Sabina A. Murphy Subodh Verma Wojtek Wojakowski Steven G. Terra Marc S. Sabatine Stephen D. Wiviott TIMI Study Group, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (B.A.B., N.A.M., A.J., J.F.K., J.-G.P., S.A.M., M.S.S., S.D.W.). Pfizer, Inc, New York, NY (C.R.B., M.C., V.R., S.G.T.). Department of Surgery, University of Toronto, Canada (S.V.). Medical University of Silesia, Katowice, Poland (W.W.)., on behalf of the TRANSLATE-TIMI 70 (...) Circulation
  Circulation, Volume 145, Issue 18, Page 1377-1386, May 3, 2022. Background:Genetic loss-of-function variants inANGPTL3are associated with lower levels of plasma lipids. Vupanorsen is a hepatically targeted antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein (...) (Circulation)
• 06:15
  Does Timing of Ventricular Tachycardia Ablation Affect Prognosis in Patients With an Implantable Cardioverter Defibrillator? Results From the Multicenter Randomized PARTITA Trial - Paolo Della Bella Francesca Baratto Pasquale Vergara Patrizia Bertocchi Matteo Santamaria Pasquale Notarstefano Leonardo Calò Daniela Orsida Luca Tomasi Marcello Piacenti Stefano Sangiorgio Francesco Pentimalli Etienne Pruvot João de Sousa Frederic Sacher Massimo Tritto Luca Rebellato Thomas Deneke Salvo Andrea Romano Martina Nesti Alessio Gargaro Daniele Giacopelli Giovanni Peretto Andrea Radinovic Department of Cardiac Electrophysiology and Arrhythmology, San Raffaele University-Hospital, Milan, Italy Cardiology Department, Ospedale di Desio, Desio (MB), Italy ardiology Department, (...) Circulation
  Circulation, Ahead of Print. Background:Optimal timing for catheter ablation of ventricular tachycardia is an important unresolved issue. There are no randomized trials evaluating the benefit of ablation after the first implantable cardioverter defibrillator (ICD) shock.Methods:We conducted a (...) (Circulation)

2 April

Circulation http://ahajournals.org/

• 06:00
  Quality of Life After Fractional Flow Reserve-Guided PCI Compared with Coronary Bypass Surgery - William F. Fearon Frederik M. Zimmermann Victoria Y. Ding Jo M. Zelis Zsolt Piroth Giedrius Davidavicius Samer Mansour Rajesh Kharbanda Nikolaos Östlund-Papadogeorgos Keith G. Oldroyd Olaf Wendler Michael J. Reardon Y. Joseph Woo Alan C. Yeung Nico H.J. Pijls Bernard De Bruyne Manisha Desai Mark A. Hlatky Division of Cardiovascular Medicine and Stanford Cardiovascular Institute, Stanford University, Stanford, CA; VA Palo Alto Health Care System, Palo Alto CA Catharina Hospital, Eindhoven, the Netherlands Quantitative Sciences Unit, Stanford University, Stanford, CA Gottsegen National (...) Circulation
  Circulation, Ahead of Print. Background:Previous studies have shown quality of life improves after coronary revascularization, more so after coronary artery bypass grafting (CABG) than after percutaneous coronary intervention (PCI). This study aimed to evaluate the impact of fractional flow (...) (Circulation)

1 April

Circulation http://ahajournals.org/

• 11:00
  Associations of Dietary Cholesterol, Serum Cholesterol, and Egg Consumption With Overall and Cause-Specific Mortality: Systematic Review and Updated Meta-Analysis - Bin Zhao Lu Gan Barry I. Graubard Satu Männistö Demetrius Albanes Jiaqi Huang National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (B.Z., L.G., J.H.). Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (B.I.G., D.A., J.H.). Department of Public Health Solutions, Finnish Institute for Health and (...) Circulation
  Circulation, Volume 145, Issue 20, Page 1506-1520, May 17, 2022. Background:Despite substantial research highlighting the importance of exogenous dietary cholesterol intake and endogenous serum cholesterol level in human health, a thorough evaluation of the associations is lacking. Our study (...) (Circulation)
• 08:00
  2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines - Paul A. Heidenreich Biykem Bozkurt David Aguilar Larry A. Allen Joni J. Byun Monica M. Colvin Anita Deswal Mark H. Drazner Shannon M. Dunlay Linda R. Evers James C. Fang Savitri E. Fedson Gregg C. Fonarow Salim S. Hayek Adrian F. Hernandez Prateeti Khazanie Michelle M. Kittleson Christopher S. Lee Mark S. Link Carmelo A. Milano Lorraine C. Nnacheta Alexander T. Sandhu Lynne Warner Stevenson Orly Vardeny Amanda R. Vest Clyde W. Yancy *Writing committee members are required to recuse themselves from voting on sections to which their specific relationships with industry may apply; see (...) Circulation
  Circulation, Volume 145, Issue 18, Page e876-e894, May 3, 2022. Aim:The “2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure” replaces the “2013 ACCF/AHA Guideline for the Management of Heart Failure” and the “2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the (...) (Circulation)
• 08:00
  2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines - Paul A. Heidenreich Biykem Bozkurt David Aguilar Larry A. Allen Joni J. Byun Monica M. Colvin Anita Deswal Mark H. Drazner Shannon M. Dunlay Linda R. Evers James C. Fang Savitri E. Fedson Gregg C. Fonarow Salim S. Hayek Adrian F. Hernandez Prateeti Khazanie Michelle M. Kittleson Christopher S. Lee Mark S. Link Carmelo A. Milano Lorraine C. Nnacheta Alexander T. Sandhu Lynne Warner Stevenson Orly Vardeny Amanda R. Vest Clyde W. Yancy *Writing committee members are required to recuse themselves from voting on sections to which their specific relationships with industry may apply; see (...) Circulation
  Circulation, Volume 145, Issue 18, Page e895-e1032, May 3, 2022. Aim:The “2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure” replaces the “2013 ACCF/AHA Guideline for the Management of Heart Failure” and the “2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the (...) (Circulation)
• 08:00
  Updated Heart Failure Guidelines: Time for a Refresh - Alanna A. Morris Javed Butler Division of Cardiology, Emory University, Atlanta, GA (A.A.M.). Baylor Scott and White Research Institute, Baylor Scott and White Health, Dallas, TX (J.B.). Circulation
  Circulation, Volume 145, Issue 18, Page 1371-1373, May 3, 2022. (Circulation)

31 March

Circulation http://ahajournals.org/

• 11:00
  Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure - Barry A. Borlaug John Blair Martin W. Bergmann Heiko Bugger Dan Burkhoff Leonhard Bruch David S. Celermajer Brian Claggett John G.F. Cleland Donald E. Cutlip Ira Dauber Jean-Christophe Eicher Qi Gao Thomas M. Gorter Finn Gustafsson Chris Hayward Jan Van der Heyden Gerd Hasenfuss Scott L. Hummel David M. Kaye Jan Komtebedde Joseph M. Massaro Jeremy A. Mazurek Scott McKenzie Shamir R. Mehta Mark C. Petrie Marco C. Post Ajith Nair Andreas Rieth Frank E. Silvestry Scott D. Solomon Jean-Noel Trochu Dirk J. van Veldhuisen Ralf Westenfeld Martin B. Leon Sanjiv J. Shah Department of (...) Circulation
  Circulation, Ahead of Print. Background:In the REDUCE LAP-HF II trial, implantation of an atrial shunt device did not provide, overall, clinical benefit for patients with heart failure and preserved or mildly reduced ejection fraction (HFpEF/HFmrEF). However, pre-specified analyses identified (...) (Circulation)

28 March

Circulation http://ahajournals.org/

• 11:00
  Coronary Artery and Cardiac Disease in Patients With Type 2 Myocardial Infarction: A Prospective Cohort Study - Anda Bularga John Hung Marwa Daghem Stacey Stewart Caelan Taggart Ryan Wereski Trisha Singh Mohammed N. Meah Takeshi Fujisawa Amy V. Ferry Justin Chiong William S. Jenkins Fiona E. Strachan Scott Semple Edwin J.R. van Beek Michelle Williams Damini Dey Chris Tuck Andrew H. Baker David E. Newby Marc R. Dweck Nicholas L. Mills Andrew R. Chapman BHF Centre for Cardiovascular Science (A.B., J.H., M.D., S.S., C.T., R.W., T.S., M.N.M., T.F., A.V.F., J.C., W.S.J., F.E.S., M.W., C.T., A.H.B., D.E.N., M.R.D., N.L.M., A.R.C.), University of Edinburgh, United Kingdom. Edinburgh Imaging (S.S., (...) Circulation
  Circulation, Volume 145, Issue 16, Page 1188-1200, April 19, 2022. Background:Type 2 myocardial infarction is caused by myocardial oxygen supply-demand imbalance, and its diagnosis is increasingly common with the advent of high-sensitivity cardiac troponin assays. Although this diagnosis is (...) (Circulation)
• 08:00
  A Tachycardia in Disguise - Giacomo Mugnai Alessia Gambaro Flavio Luciano Ribichini Division of Cardiology, Department of Medicine, School of Medicine, University of Verona, Verona, Italy. Circulation
  Circulation, Volume 145, Issue 13, Page 1024-1028, March 29, 2022. (Circulation)
• 08:00
  Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications - Trisha Singh Hilal Khan David T. Gamble Caroline Scally David E. Newby Dana Dawson British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (T.S., C.S., D.E.N.). Aberdeen Cardiovascular and Diabetes Centre, University of Aberdeen, United Kingdom (H.K., D.T.G., D.D.). Circulation
  Circulation, Volume 145, Issue 13, Page 1002-1019, March 29, 2022. Takotsubo syndrome is a condition characterized by acute transient left ventricular systolic dysfunction, which at presentation can be challenging to distinguish from acute myocardial infarction. Although previously thought to (...) (Circulation)
• 08:00
  Equipoise in Clinical Trials: Enough Uncertainty in Whose Opinion? - John H. Alexander Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC. Circulation
  Circulation, Volume 145, Issue 13, Page 943-945, March 29, 2022. (Circulation)
• 08:00
  Empagliflozin Reverses Late Na+ Current Enhancement and Cardiomyocyte Proarrhythmia in a Translational Murine Model of Heart Failure With Preserved Ejection Fraction - Bence Hegyi Juliana Mira Hernandez Erin Y. Shen Nima R. Habibi Julie Bossuyt Donald M. Bers Department of Pharmacology, University of California, Davis (B.H., J.M.H., E.Y.S., N.R.H., J.B., D.M.B.). Research Group in Veterinary Medicine (GIVET), School of Veterinary Medicine, University Corporation Lasallista (Unilasallista), Caldas, Antioquia, Colombia (J.M.H.). Circulation
  Circulation, Volume 145, Issue 13, Page 1029-1031, March 29, 2022. (Circulation)
• 08:00
  Activation of iNKT Cells at the Maternal–Fetal Interface Predisposes Offspring to Cardiac Injury - Dayan Cao Ying Liu Xin Chen Jie Liu Jie Liu Wenjing Lai Shuhui Li Wenjia Wang Wenjun Zhang Deyong Xiao Kai Yang Baiyan Li Zhongjun Zhou Chen-Leng Cai Xiaohui Li Weinian Shou Institute of Materia Medica and Center of Translational Medicine (D.C., J.L., J.L., X.C., W.W., X.L.), Army Medical University, Chongqing, China. Department of Pharmacy, Xinqiao Hospital (W.L.), Army Medical University, Chongqing, China. Department of Clinical Biochemistry, College of Pharmacy (S.L.), Army Medical University, Chongqing, China. Herman B Wells Center for Pediatric Research, Department of Pediatrics, (...) Circulation
  Circulation, Volume 145, Issue 13, Page 1032-1035, March 29, 2022. (Circulation)
• 08:00
  Higher Risk of Heart Disease Among South Asians Calls for Targeted Interventions - Bridget M. Kuehn Circulation
  Circulation, Volume 145, Issue 13, Page 1020-1021, March 29, 2022. (Circulation)
• 08:00
  From the Literature - Tracy Hampton Circulation
  Circulation, Volume 145, Issue 13, Page 1022-1023, March 29, 2022. (Circulation)
• 08:00
  Atrial Fibrillation Screening: The Tools Are Ready, But Should We Do It? - Fabrice Extramiana Philippe Gabriel Steg Université de Paris, INSERM-1148, France (P.G.S.). Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, France (F.E., P.G.S.). French Alliance for Cardiovascular Trials, Paris, France (P.G.S.). Imperial College, Royal Brompton Hospital, London, UK (P.G.S.). Circulation
  Circulation, Volume 145, Issue 13, Page 955-958, March 29, 2022. (Circulation)
• 08:00
  Insulin and Bile Acids in Cholesterol Homeostasis: New Players in Diabetes-Associated Atherosclerosis - Víctor Cortés Robert H. Eckel Department of Nutrition, Diabetes and Metabolism, Pontificia Universidad Católica de Chile, Santiago (V.C.). Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, (R.H.E.). Circulation
  Circulation, Volume 145, Issue 13, Page 983-986, March 29, 2022. (Circulation)

23 March

Circulation http://ahajournals.org/

• 10:00
  Novel CaMKII-? Inhibitor Hesperadin Exerts Dual Functions to Ameliorate Cardiac Ischemia/Reperfusion Injury and Inhibit Tumor Growth - Junxia Zhang Ruqi Liang Kai Wang Wenjia Zhang Mao Zhang Li Jin Peng Xie Wen Zheng Haibao Shang Qingmei Hu Jiayi Li Gengjia Chen Fujian Wu Feng Lan Lipeng Wang Shi-Qiang Wang Yongfeng Li Yong Zhang Jinghao Liu Fengxiang Lv Xinli Hu Rui-Ping Xiao Xiaoguang Lei Yan Zhang State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, College of Future Technology (J.Z., M.Z., L.J., P.X., W. Zheng, H.S., Q.H., J. Li, G.C., J. Liu, F.L., X.H., R.-P.X., Yan Zhang), Peking University, Beijing, China. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic (...) Circulation
  Circulation, Volume 145, Issue 15, Page 1154-1168, April 12, 2022. Background:Cardiac ischemia/reperfusion (I/R) injury has emerged as an important therapeutic target for ischemic heart disease, the leading cause of morbidity and mortality worldwide. At present, there is no effective therapy (...) (Circulation)

22 March

Circulation http://ahajournals.org/

• 10:00
  Randomized Ablation-Based Rhythm-Control Versus Rate-Control Trial in Patients with Heart Failure and Atrial Fibrillation: Results from the RAFT-AF trial - Ratika Parkash George A. Wells Jean Rouleau Mario Talajic Vidal Essebag Allan Skanes Stephen B. Wilton Atul Verma Jeffrey S. Healey Laurence Sterns Matthew Bennett Jean-Francois Roux Lena Rivard Peter Leong-Sit Mats Jensen-Urstad Umjeet Jolly François Philippon John L. Sapp Anthony S.L. Tang Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada University of Ottawa Cardiovascular Research Methods Centre, Ottawa, ON, Canada Montreal Heart Institute, Université de Montréal, Montreal, QC, Canada McGill University Health Centre, Montreal, QC, Canada Schulich School of Medicine (...) Circulation
  Circulation, Ahead of Print. Background:Atrial fibrillation (AF) and heart failure (HF) frequently coexist and can be challenging to treat. Pharmacologic based rhythm-control of AF has not proven to be superior to rate-control. Ablation-based rhythm-control was compared to rate-control to (...) (Circulation)

21 March

Circulation http://ahajournals.org/

• 13:00
  Cost-Effectiveness of a Household Salt Substitution Intervention: Findings From 20 995 Participants of the Salt Substitute and Stroke Study - Ka-Chun Li Liping Huang Maoyi Tian Gian Luca Di Tanna Jie Yu Xinyi Zhang Xuejun Yin Yishu Liu Zhixin Hao Bo Zhou Xiangxian Feng Zhifang Li Jianxin Zhang Jixin Sun Yuhong Zhang Yi Zhao Ruijuan Zhang Yan Yu Nicole Li Lijing L. Yan Darwin R. Labarthe Paul Elliott Yangfeng Wu Bruce Neal Thomas Lung Lei Si The George Institute for Global Health, University of New South Wales, Sydney, Australia (K.-C.L., L.H., M.T., G.L.D.T., J.Y., X.Y., Y.L., N.L., B.N., T.L., L.S.). School of Public Health, Harbin Medical University, China (M.T.). Department of Cardiology, Peking University Third Hospital, (...) Circulation
  Circulation, Volume 145, Issue 20, Page 1534-1541, May 17, 2022. Background:SSaSS (Salt Substitute and Stroke Study), a 5-year cluster randomized controlled trial, demonstrated that replacing regular salt with a reduced-sodium, added-potassium salt substitute reduced the risks of stroke, major (...) (Circulation)
• 08:00
  Understanding the Importance of the Lay Responder Experience in Out-of-Hospital Cardiac Arrest: A Scientific Statement From the American Heart Association - Katie N. Dainty Brianna Colquitt Farhan Bhanji Elizabeth A. Hunt Tiffany Jefkins Marion Leary Joseph P. Ornato Robert A. Swor Ashish Panchal Circulation
  Circulation, Volume 145, Issue 17, Page e852-e867, April 26, 2022. Bystander cardiopulmonary resuscitation (CPR) is critical to increasing survival from out-of-hospital cardiac arrest. However, the percentage of cases in which an individual receives bystander CPR is actually low, at only 35% to (...) (Circulation)
• 07:00
  Hemophagocytic Lymphohistiocytosis Associated With Endocarditis: A Case Years in the Making - Vanessa Blumer Joshua B. Parsons D. Ryan Anderson Gerald S. Bloomfield Cary Ward Division of Cardiology, Department of Medicine (V.B., G.S.B., C.W.), Duke University Medical Center, Durham, NC. Division of Infectious Diseases, Department of Medicine (J.B.P.), Duke University Medical Center, Durham, NC. Division of Rheumatology, Department of Medicine (D.R.A.), Duke University Medical Center, Durham, NC. Duke Clinical Research Institute, Durham, NC (V.B., (...) Circulation
  Circulation, Volume 145, Issue 12, Page 934-939, March 22, 2022. (Circulation)
• 07:00
  Is Asymptomatic Severe Aortic Stenosis Still a Waiting Game? - Graham S. Hillis Gerry P. McCann David E. Newby Department of Cardiology, Royal Perth Hospital and Medical School, University of Western Australia, Perth (G.S.H.). Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (G.P.M.). British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (D.E.N.). Circulation
  Circulation, Volume 145, Issue 12, Page 874-876, March 22, 2022. (Circulation)
• 07:00
  Letter by Ng et al Regarding Article, “Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial” - Chi Fai Ng Jeremy Y.C. Teoh Peter K.F. Chiu The Chinese University of Hong Kong, China. Circulation
  Circulation, Volume 145, Issue 12, Page e773-e774, March 22, 2022. (Circulation)
• 07:00
  Inherited Thrombophilias Are Associated With a Higher Risk of COVID-19–Associated Venous Thromboembolism: A Prospective Population-Based Cohort Study - Hannah Stevens Rodrigo Canovas Huyen Tran Karlheinz Peter James D. McFadyen Department of Haematology (H.S., H.T., J.M.), Alfred Hospital, Melbourne, Victoria, Australia. Department of Cardiology (K.P.), Alfred Hospital, Melbourne, Victoria, Australia. Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia (H.S., H.T., J.M.). Atherothrombosis and Vascular Biology Program (H.S., K.P., J.M.), Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia. Cambridge Baker Systems Genomics Initiative (R.C.), Baker Heart and Diabetes Institute, Melbourne, (...) Circulation
  Circulation, Volume 145, Issue 12, Page 940-942, March 22, 2022. (Circulation)
• 07:00
  Correction to: Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association Circulation
  Circulation, Volume 145, Issue 12, Page e775-e775, March 22, 2022. (Circulation)
• 07:00
  First Steps of Population Genomic Medicine in the Arrhythmia World: Pros and Cons - Roddy Walsh Connie Bezzina Arthur A.M. Wilde Amsterdam University Medical Centres, University of Amsterdam, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands (R.W., C.B., A.A.M.W.). European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (C.B., A.A.M.W.). Circulation
  Circulation, Volume 145, Issue 12, Page 892-895, March 22, 2022. (Circulation)

18 March

Circulation http://ahajournals.org/

• 10:00
  Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization - Albert Henry María Gordillo-Marañón Chris Finan Amand F. Schmidt João Pedro Ferreira Ravi Karra Johan Sundström Lars Lind Johan Ärnlöv Faiez Zannad Anders Mälarstig Aroon D. Hingorani R. Thomas Lumbers Institute of Cardiovascular Science (A.H., M.G.-M., C.F., A.F.S., A.D.H.), University College London, United Kingdom. British Heart Foundation Research Accelerator (A.H., M.G.-M., C.F., A.F.S., A.D.H., R.T.L.), University College London, United Kingdom. Institute of Health Informatics (A.H., R.T.L.), University College London, United Kingdom. Health Data Research UK London (R.T.L.), University (...) Circulation
  Circulation, Volume 145, Issue 16, Page 1205-1217, April 19, 2022. Background:Heart failure (HF) is a highly prevalent disorder for which disease mechanisms are incompletely understood. The discovery of disease-associated proteins with causal genetic evidence provides an opportunity to identify (...) (Circulation)

17 March

Circulation http://ahajournals.org/

• 10:00
  MicroRNA-210 Controls Mitochondrial Metabolism and Protects Heart Function in Myocardial Infarction - Rui Song Chiranjib Dasgupta Cassidy Mulder Lubo Zhang Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, CA. Circulation
  Circulation, Volume 145, Issue 15, Page 1140-1153, April 12, 2022. Background:Ischemic heart disease remains a leading cause of death worldwide. In this study, we test the hypothesis that microRNA-210 protects the heart from myocardial ischemia-reperfusion (IR) injury by controlling (...) (Circulation)

14 March

Circulation http://ahajournals.org/

• 11:00
  Age and Racial/Ethnic Disparities in Pediatric Out-of-Hospital Cardiac Arrest - Aditya C. Shekhar Teri Campbell N. Clay Mann Ira J. Blumen Manu Madhok Center for Bioethics, Harvard Medical School, Boston, MA (A.C.S.). University of Minnesota-Twin Cities (A.C.S., M.M.), Minneapolis. Department of Emergency Medicine, Children’s Minnesota (M.M.), Minneapolis. University of Chicago Aeromedical Network (T.C., I.J.B.), University of Chicago, IL. Department of Emergency Medicine (I.J.B.)., University of Chicago, IL. Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (...) Circulation
  Circulation, Volume 145, Issue 16, Page 1288-1289, April 19, 2022. (Circulation)
• 07:00
  Curious ECG Morphology of a Cardiac Device: A New Normal? - Caroline E. Murphy Kyle D. Bartol John G. Symons Department of Cardiology, Walter Reed National Military Medical Center, Bethesda, MD. Circulation
  Circulation, Volume 145, Issue 11, Page 864-867, March 15, 2022. (Circulation)
• 07:00
  Clinical Trial Design Principles and Outcomes Definitions for Device-Based Therapies for Hypertension: A Consensus Document From the Hypertension Academic Research Consortium - David E. Kandzari Felix Mahfoud Michael A. Weber Raymond Townsend Gianfranco Parati Naomi D.L. Fisher Melvin D. Lobo Michael Bloch Michael Böhm Andrew S.P. Sharp Roland E. Schmieder Michel Azizi Markus P. Schlaich Vasilios Papademetriou Ajay J. Kirtane Joost Daemen Atul Pathak Christian Ukena Philipp Lurz Guido Grassi Martin Myers Aloke V. Finn Marie-Claude Morice Roxana Mehran Peter Jüni Gregg W. Stone Mitchell W. Krucoff Paul K. Whelton Konstantinos Tsioufis Donald E. Cutlip Ernest Spitzer Piedmont Heart Institute, Atlanta, GA (D.E.K.). Klinik für Innere Medizin III, Kardiologie, (...) Circulation
  Circulation, Volume 145, Issue 11, Page 847-863, March 15, 2022. The clinical implications of hypertension in addition to a high prevalence of both uncontrolled blood pressure and medication nonadherence promote interest in developing device-based approaches to hypertension treatment. The (...) (Circulation)
• 07:00
  Sublingual Nitrates for Patients as a Default in the Post-ACS Discharge Pack: Is It Time for a Rethink? - Avedis A. Ekmejian Ravinay Bhindi Gemma A. Figtree Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (A.A.E., R.B., G.A.F.). Cardiovascular Discovery Group, Kolling Institute of Medical Research (R.B., G.A.F.), University of Sydney, Australia. Charles Perkins Centre (G.A.F.), University of Sydney, Australia. Circulation
  Circulation, Volume 145, Issue 11, Page 791-792, March 15, 2022. (Circulation)
• 07:00
  Myocardial Edema Provides a Link Between Pulmonary Arterial Hypertension and Pericardial Effusion - Randolph H. Stewart Charles S. Cox Steven J. Allen Glen A. Laine Michael E. DeBakey Institute (R.H.S., C.S.C., S.J.A., G.A.L), Texas A&M University, College Station. Department of Veterinary Physiology and Pharmacology (R.H.S.), Texas A&M University, College Station. McGovern Medical School at UTHealth, University of Texas Health Science Center at Houston (C.S.C.). Circulation
  Circulation, Volume 145, Issue 11, Page 793-795, March 15, 2022. (Circulation)
• 07:00
  Letter by Feng and Nie Regarding Article, “Myeloid-Derived Growth Factor Protects Against Pressure Overload-Induced Heart Failure” - Jie Feng Yu Nie State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing. Circulation
  Circulation, Volume 145, Issue 11, Page e768-e769, March 15, 2022. (Circulation)
• 07:00
  Response by Wollert to Letter Regarding Article, “Myeloid-Derived Growth Factor Protects Against Pressure Overload-Induced Heart Failure” - Kai C. Wollert Division of Molecular and Tanslational Cardiology, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany. Circulation
  Circulation, Volume 145, Issue 11, Page e770-e770, March 15, 2022. (Circulation)
• 07:00
  Shaping Value-Based Payment Policy: Improving Heart Health Through Value-Based Payment - Keith Churchwell Donald M. Lloyd-Jones Melanie Phelps Yale New Haven Hospital, New Haven, CT (K.C.). Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (D.M.L.-J.). American Heart Association, Dallas, TX (M.P.). Circulation
  Circulation, Volume 145, Issue 11, Page e765-e767, March 15, 2022. (Circulation)
• 07:00
  Correction to: 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines Circulation
  Circulation, Volume 145, Issue 11, Page e771-e771, March 15, 2022. (Circulation)
• 07:00
  Correction to: 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines Circulation
  Circulation, Volume 145, Issue 11, Page e772-e772, March 15, 2022. (Circulation)
• 07:00
  Atrial Fibrillation Ablation: Aiming to Improve Quantity and Quality of Life - Jason G. Andrade Laurent Macle University of British Columbia, Vancouver, Canada (J.G.A.). Center for Cardiovascular Innovation, Vancouver, Canada (J.G.A.). Montreal Heart Institute, Université de Montréal, Canada (J.G.A., L.M.). Circulation
  Circulation, Volume 145, Issue 11, Page 805-807, March 15, 2022. (Circulation)

9 March

Circulation http://ahajournals.org/

• 11:00
  Comprehensive Quality-of-Life Outcomes With Invasive Versus Conservative Management of Chronic Coronary Disease in ISCHEMIA - Daniel B. Mark John A. Spertus Robert Bigelow Sophia Anderson Melanie R. Daniels Kevin J. Anstrom Khaula N. Baloch David J. Cohen Claes Held Shaun G. Goodman Sripal Bangalore Derek Cyr Harmony R. Reynolds Karen P. Alexander Yves Rosenberg Gregg W. Stone David J. Maron Judith S. Hochman Duke Clinical Research Institute, Duke University, Durham, NC (D.B.M., R.B., S.A., M.R.D., K.J.A., K.N.B., D.C., K.P.A.). Saint Luke’s Mid America Heart Institute/University of Missouri, Kansas City (J.A.S.). Cardiovascular Research Foundation, New York (D.J.C.). St. Francis Hospital and Heart Center, (...) Circulation
  Circulation, Volume 145, Issue 17, Page 1294-1307, April 26, 2022. Background:ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) compared an initial invasive treatment strategy (INV) with an initial conservative strategy in 5179 participants (...) (Circulation)

7 March

Circulation http://ahajournals.org/

• 11:00
  Beyond 10-Year Risk: A Cost-Effectiveness Analysis of Statins for the Primary Prevention of Cardiovascular Disease - Ciaran N. Kohli-Lynch James Lewsey Kathleen A. Boyd Dustin D. French Neil Jordan Andrew E. Moran Naveed Sattar David Preiss Andrew H. Briggs Center for Health Services and Outcomes Research (C.N.K.-L., D.D.F., N.J.), Feinberg School of Medicine, Northwestern University, Chicago, IL. Departments of Ophthalmology and Medical Social Science (D.D.F.), Feinberg School of Medicine, Northwestern University, Chicago, IL. Psychiatry & Behavioral Sciences and Preventive Medicine (N.J.), Feinberg School of Medicine, Northwestern University, Chicago, IL. Health Economics and Health Technology (...) Circulation
  Circulation, Volume 145, Issue 17, Page 1312-1323, April 26, 2022. Background:Cholesterol guidelines typically prioritize primary prevention statin therapy on the basis of 10-year risk of cardiovascular disease. The advent of generic pricing may justify expansion of statin eligibility. (...) (Circulation)
• 11:01
  Critical Illness Among Patients Hospitalized With Acute COVID-19 With and Without Congenital Heart Defects - Karrie F. Downing Regina M. Simeone Matthew E. Oster Sherry L. Farr Centers for Disease Control and Prevention COVID-19 Response Team, Atlanta, GA (K.F.D., R.M.S.). National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA (K.F.D., M.E.O., S.L.F.). Children’s Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA (M.E.O.). Circulation
  Circulation, Volume 145, Issue 15, Page 1182-1184, April 12, 2022. (Circulation)
• 11:00
  Cardio-Oncology Drug Interactions: A Scientific Statement From the American Heart Association - Craig J. Beavers Jo E. Rodgers Aaron J. Bagnola Theresa M. Beckie Umberto Campia Katherine E. Di Palo Tochi M. Okwuosa Eugene R. Przespolewski Susan Dent Circulation
  Circulation, Volume 145, Issue 15, Page e811-e838, April 12, 2022. In the cardio-oncology population, drug interactions are of particular importance given the complex pharmacological profile, narrow therapeutic index, and inherent risk of therapies used to manage cardiovascular disease and (...) (Circulation)
• 08:00
  Rare Case of Wide QRS Tachycardia After Sintilimab Treatment for Lung Cancer - Yi Tang Yi Zhang Xiao-Yan Yang Department of Cardiology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, Changsha, China. Circulation
  Circulation, Volume 145, Issue 10, Page 783-786, March 8, 2022. (Circulation)
• 08:00
  CYP2C19 Genotyping in Anticoagulated Patients After Percutaneous Coronary Intervention: Should It Be Routine? - Dimitri J. Maamari Farouc A. Jaffer Amit V. Khera Akl C. Fahed Center for Genomic Medicine (D.J.M., A.V.K., A.C.F.), Massachusetts General Hospital Division of Cardiology (F.A.J., A.V.K., A.C.F.), Department of Medicine, Massachusetts General Hospital Cardiovascular Research Center, Cardiology Division (F.A.J., A.C.F.), Massachusetts General Hospital Department of Medicine, Harvard Medical School (F.A.J., A.V.K., A.C.F.) Boston. Cardiovascular Disease Initiative, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge (D.J.M., A.V.K., (...) Circulation
  Circulation, Volume 145, Issue 10, Page 721-723, March 8, 2022. (Circulation)
• 08:00
  Letter by Nagareddy and Sreejit Regarding Article, “Interleukin-1? Is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease” - Prabhakara R. Nagareddy Gopalkrishna Sreejit Division of Cardiac Surgery, Department of Surgery, Ohio State University Wexner Medical Center, Columbus. Circulation
  Circulation, Volume 145, Issue 10, Page e762-e763, March 8, 2022. (Circulation)
• 08:00
  Response by Schunk and Speer to the Letter Regarding Article, “Interleukin-1? Is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease” - Stefan J. Schunk Thimoteus Speer Department of Internal Medicine IV, Nephrology and Hypertension (S.J.S., T.S.), Saarland University, Homburg/Saar, Germany. Translational Cardio-Renal Medicine (T.S.), Saarland University, Homburg/Saar, Germany. Circulation
  Circulation, Volume 145, Issue 10, Page e764-e764, March 8, 2022. (Circulation)
• 08:00
  Efficient In Vivo Homology-Directed Repair Within Cardiomyocytes - Yanjiang Zheng Nathan J. VanDusen Catalina E. Butler Qing Ma Justin S. King William T. Pu Department of Biochemistry, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China (Y.Z.). Department of Cardiology, Boston Children’s Hospital, MA (Y.Z., N.J.V., C.E.B., Q.M., J.S.K., W.T.P.). Harvard Stem Cell Institute, Cambridge, MA (W.T.P.). Circulation
  Circulation, Volume 145, Issue 10, Page 787-789, March 8, 2022. (Circulation)
• 08:00
  Are 2 Left Atrial Appendage Guards Better Than 1? The Amulet IDE Randomized Trial - Christopher Kowalewski Nikolaos Dagres Gerhard Hindricks Heart Center Leipzig at University Leipzig, Department of Cardiology and Electrophysiology, HELIOS Kliniken GmbH, Leipzig, Germany. Circulation
  Circulation, Volume 145, Issue 10, Page 739-741, March 8, 2022. (Circulation)

3 March

Circulation http://ahajournals.org/

• 11:00
  Heteroplasmy of Wild-Type Mitochondrial DNA Variants in Mice Causes Metabolic Heart Disease With Pulmonary Hypertension and Frailty - Ana Victoria Lechuga-Vieco Ana Latorre-Pellicer Enrique Calvo Carlos Torroja Juan Pellico Rebeca Acín-Pérez María Luisa García-Gil Arnoldo Santos Navratan Bagwan Elena Bonzon-Kulichenko Ricardo Magni Marina Benito Raquel Justo-Méndez Anna Katharina Simon Fátima Sánchez-Cabo Jesús Vázquez Jesús Ruíz-Cabello José Antonio Enríquez Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain (A.V.L.-V., R.M., M.B., R.J.-M., J.R.-C.). The Kennedy Institute of Rheumatology, NDORMS, University of Oxford, UK (A.V.L.-V., A.K.S.). Ciber de Enfermedades Respiratorias (CIBERES), Madrid, Spain (...) Circulation
  Circulation, Volume 145, Issue 14, Page 1084-1101, April 5, 2022. Background:In most eukaryotic cells, the mitochondrial DNA (mtDNA) is transmitted uniparentally and present in multiple copies derived from the clonal expansion of maternally inherited mtDNA. All copies are therefore (...) (Circulation)

2 March

Circulation http://ahajournals.org/

• 11:00
  Screening for Atrial Fibrillation in Older Adults at Primary Care Visits: VITAL-AF Randomized Controlled Trial - Steven A. Lubitz Steven J. Atlas Jeffrey M. Ashburner Ana T. Trisini Lipsanopoulos Leila H. Borowsky Wyliena Guan Shaan Khurshid Patrick T. Ellinor Yuchiao Chang David D. McManus Daniel E. Singer Demoulas Center for Cardiac Arrhythmias and Cardiovascular Research Center (S.A.L., S.K., P.T.E.), Massachusetts General Hospital, Boston. Division of General Internal Medicine (S.J.A., J.M.A., L.H.B., Y.C., D.E.S.), Massachusetts General Hospital, Boston. Division of Cardiology (A.T.T.L.), Massachusetts General Hospital, Boston. Harvard Medical School, Boston, MA (S.A.L., J.M.A., S.K., P.T.E., (...) Circulation
  Circulation, Volume 145, Issue 13, Page 946-954, March 29, 2022. Background:Undiagnosed atrial fibrillation (AF) may cause preventable strokes. Guidelines differ regarding AF screening recommendations. We tested whether point-of-care screening with a handheld single-lead ECG at primary care (...) (Circulation)
• 06:17
  DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics - Lingfang Zhuang Kangni Jia Chen Chen Zhigang Li Jiaxin Zhao Jian Hu Hang Zhang Qin Fan Chunkai Huang Hongyang Xie Lin Lu Weifeng Shen Guang Ning Jiqiu Wang Ruiyan Zhang Kang Chen Xiaoxiang Yan Department of Cardiovascular Medicine (L.Z., K..J., Z.L., J.Z., J.H., H.Z., Q.F., C.H., H.X., L.L., W.S., R.Z., K.C., X.Y.), Shanghai Jiao Tong University School of Medicine, Shanghai, PR China. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases (G.N., J.W.), Shanghai Jiao Tong University School of Medicine, Shanghai, PR China. Ruijin Hospital, (...) Circulation
  Circulation, Volume 145, Issue 11, Page 829-846, March 15, 2022. Background:Heart failure is a global public health issue that is associated with increasing morbidity and mortality. Previous studies have suggested that mitochondrial dysfunction plays critical roles in the progression of heart (...) (Circulation)

28 February

Circulation http://ahajournals.org/

• 08:00
  Heart of Gold: A Scintillating Pericardial Effusion - Lee Bockus Kenta Nakamura Michael Chen University of Washington Medical Center (L.B., K.N.), University of Washington Division of Cardiology, Seattle. Harborview Medical Center (K.N., M.C.), University of Washington Division of Cardiology, Seattle. Circulation
  Circulation, Volume 145, Issue 9, Page 713-717, March 1, 2022. (Circulation)
• 08:00
  Evidence-Based Medical Therapy in Patients With Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease - Iris E. Beldhuis Carolyn S.P. Lam Jeffrey M. Testani Adriaan A. Voors Harriette G.C. Van Spall Jozine M. ter Maaten Kevin Damman University of Groningen, Department of Cardiology, University Medical Center Groningen, The Netherlands (I.E.B., C.S.P.L., A.A.V., J.M.t.M., K.D.). National Heart Centre Singapore and Duke-National University of Singapore (C.S.P.L.). Department of Internal Medicine, Section of Cardiology, Yale University School of Medicine, New Haven, CT (J.M.T.). Department of Medicine (H.G.C.V.S.), McMaster University, Hamilton, Canada. Department of Health Research Methods, (...) Circulation
  Circulation, Volume 145, Issue 9, Page 693-712, March 1, 2022. Chronic kidney disease (CKD) as identified by a reduced estimated glomerular filtration rate (eGFR) is a common comorbidity in patients with heart failure with reduced ejection fraction (HFrEF). The presence of CKD is associated (...) (Circulation)
• 08:00
  What Are Adaptive Platform Clinical Trials and What Role May They Have in Cardiovascular Medicine? - Patrick R. Lawler Judith S. Hochman Ryan Zarychanski Peter Munk Cardiac Centre, Toronto General Hospital, Canada (P.R.L.). Division of Cardiology and Interdepartmental Division of Critical Care Medicine, University of Toronto, Canada (P.R.L.). Cardiovascular Clinical Research Center and Division of Cardiology, New York University Langone Health, New York University Grossman School of Medicine (J.S.H.). University of Manitoba, Max Rady College of Medicine, Department of Internal Medicine, Sections of Hematology/Medical Oncology and Critical Care, Winnipeg, Canada (R.Z). CancerCare (...) Circulation
  Circulation, Volume 145, Issue 9, Page 629-632, March 1, 2022. (Circulation)
• 08:00
  Letter by Lucas and Taegtmeyer Regarding Article, “One-Year Committed Exercise Training Reverses Abnormal Left Ventricular Myocardial Stiffness in Patients With Stage B Heart Failure With Preserved Ejection Fraction” - Claire Huang Lucas Heinrich Taegtmeyer Division of Cardiology, Department of Internal Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston. Circulation
  Circulation, Volume 145, Issue 9, Page e642-e643, March 1, 2022. (Circulation)
• 08:00
  Response by Hieda and Levine to Letter Regarding Article, “One-Year Committed Exercise Training Reverses Abnormal Left Ventricular Myocardial Stiffness in Patients With Stage B Heart Failure With Preserved Ejection Fraction” - Michinari Hieda Benjamin D. Levine Department of Medicine and Biosystemic Science, Hematology, Oncology, and Cardiovascular Medicine, School of Medicine, Kyushu University, Fukuoka, Japan (M.H.). Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (B.D.L.). University of Texas Southwestern Medical Center, Dallas (B.D.L.). Circulation
  Circulation, Volume 145, Issue 9, Page e644-e644, March 1, 2022. (Circulation)
• 08:00
  Efficacy and Safety of Edoxaban 15 mg According to Renal Function in Very Elderly Patients With Atrial Fibrillation: A Subanalysis of the ELDERCARE-AF Trial - Tetsuro Yoshida Akihiro Nakamura Junichi Funada Mari Amino Wataru Shimizu Masayuki Fukuzawa Saori Watanabe Takuya Hayashi Takeshi Yamashita Ken Okumura Masaharu Akao Department of Cardiovascular Medicine, Onga Nakama Medical Association Onga Hospital, Japan (T. Yoshida). Department of Cardiology, Iwate Prefectural Central Hospital, Morioka, Japan (A.N.). Department of Cardiology, National Hospital Organization Ehime Medical Center, Toon, Japan (J.F.). Department of Cardiology, Tokai University, Isehara, Japan (M.A.). Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, (...) Circulation
  Circulation, Volume 145, Issue 9, Page 718-720, March 1, 2022. (Circulation)
• 08:00
  Correction to: 2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Neonatal Life Support; Education, Implementation, and Teams; First Aid Task Forces; and the COVID-19 Working Group Circulation
  Circulation, Volume 145, Issue 9, Page e760-e760, March 1, 2022. (Circulation)
• 08:00
  Correction to: Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis: The AVATAR Trial Circulation
  Circulation, Volume 145, Issue 9, Page e761-e761, March 1, 2022. (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 145, Issue 9, Page 688-692, March 1, 2022. (Circulation)
• 08:00
  Taming Hypertension to Prevent Aortic Dissection: Universal Recognition of a “New Normal” Blood Pressure? - Christoph A. Nienaber Xun Yuan Cardiology and Aortic Centre, Royal Brompton and Harefield Hospitals, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK (C.A.N., X.Y.). National Heart and Lung Institute, Faculty of Medicine, Imperial College London, UK. (C.A.N., X.Y.). Circulation
  Circulation, Volume 145, Issue 9, Page 645-647, March 1, 2022. (Circulation)

25 February

Circulation http://ahajournals.org/

• 11:00
  Nationwide Analysis of Persistent Type II Endoleak and Late Outcomes of Endovascular Abdominal Aortic Aneurysm Repair in Japan: A Propensity-Matched Analysis - Yoshimasa Seike Hitoshi Matsuda Hideyuki Shimizu Shin Ishimaru Katsuyuki Hoshina Nobuaki Michihata Hideo Yasunaga Kimihiro Komori Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan (Y.S., H.M.). Department of Cardiovascular Surgery, Keio University, Tokyo, Japan (H.S.). Department of Cardiovascular Surgery, Toda Chuo General Hospital, Saitama, Japan (S.I.). Department of Vascular Surgery (K.H.), University of Tokyo, Japan. Department of Clinical Epidemiology and Health Economics, School of Public Health (N.M., H.Y.), University of Tokyo, (...) Circulation
  Circulation, Volume 145, Issue 14, Page 1056-1066, April 5, 2022. Background:We reviewed the results of endovascular aneurysm repair in patients from the Japanese Committee for Stentgraft Management registry to determine the significance of persistent type II endoleak (p-T2EL) and the risk of (...) (Circulation)
• 10:15
  Cytokine Hemoadsorption During Cardiac Surgery Versus Standard Surgical Care for Infective Endocarditis (REMOVE): Results From a Multicenter Randomized Controlled Trial - Mahmoud Diab Thomas Lehmann Wolfgang Bothe Payam Akhyari Stephanie Platzer Daniel Wendt Antje-Christin Deppe Justus Strauch Stefan Hagel Albrecht Günther Gloria Faerber Christoph Sponholz Marcus Franz André Scherag Ilia Velichkov Miriam Silaschi Jens Fassl Britt Hofmann Sven Lehmann Rene Schramm Georg Fritz Gabor Szabo Thorsten Wahlers Klaus Matschke Artur Lichtenberg Mathias W. Pletz Jan F. Gummert Friedhelm Beyersdorf Christian Hagl Michael A. Borger Michael Bauer Frank M. Brunkhorst Torsten Doenst Department of Cardiothoracic Surgery (M.D., G. Faerber, I.V., T.D.), Jena University (...) Circulation
  Circulation, Volume 145, Issue 13, Page 959-968, March 29, 2022. Background:Cardiac surgery often represents the only treatment option in patients with infective endocarditis (IE). However, IE surgery may lead to a sudden release of inflammatory mediators, which is associated with postoperative (...) (Circulation)

23 February

Circulation http://ahajournals.org/

• 11:00
  Insulin Prevents Hypercholesterolemia by Suppressing 12?-Hydroxylated Bile Acids - Ivana Semova Amy E. Levenson Joanna Krawczyk Kevin Bullock Mary E. Gearing Alisha V. Ling Kathryn A. Williams Ji Miao Stuart S. Adamson Dong-Ju Shin Satyapal Chahar Mark J. Graham Rosanne M. Crooke Lee R. Hagey David Vicent Sarah D. de Ferranti Srividya Kidambi Clary B. Clish Sudha B. Biddinger Division of Endocrinology (I.S., A.E.L., J.K., M.E.G., A.V.L., J.M., S.S.A., D.-J.S., S.C., S.B.B.), Boston Children’s Hospital, Harvard Medical School, MA. Department of Cardiology (S.D.d.F.), Boston Children’s Hospital, Harvard Medical School, MA. Broad Institute of MIT and Harvard, Cambridge, MA (...) Circulation
  Circulation, Volume 145, Issue 13, Page 969-982, March 29, 2022. Background:The risk of cardiovascular disease in type 1 diabetes remains extremely high, despite marked advances in blood glucose control and even the widespread use of cholesterol synthesis inhibitors. Thus, a deeper (...) (Circulation)

22 February

Circulation http://ahajournals.org/

• 11:00
  Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis - Jin-Kai Wang Yang Li Xiao-Lu Zhao Yuan-Bin Liu Jing Tan Yu-Ying Xing Dilare Adi Yong-Tao Wang Zhen-Yan Fu Yi-Tong Ma Song-Mei Liu Yong Liu Yan Wang Xiong-Jie Shi Xiao-Yi Lu Bao-Liang Song Jie Luo Institute for Advanced Studies, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, China (J.-K.W., X.-L.Z., Y.-B.L., J.T., Y.-Y.X., Y. Liu, Y.W., X.-J.S., X.-Y.L., B.-L.S., J.L.). Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China (Y. Li, D.A., (...) Circulation
  Circulation, Volume 145, Issue 9, Page 675-687, March 1, 2022. Background:High blood cholesterol accelerates the progression of atherosclerosis, which is an asymptomatic process lasting for decades. Rupture of atherosclerotic plaques induces thrombosis, which results in myocardial infarction or (...) (Circulation)

21 February

Circulation http://ahajournals.org/

• 11:00
  e-Cigarette Aerosol Reduces Left Ventricular Function in Adolescent Mice - Evan W. Neczypor Ty A. Saldaña Matthew J. Mears David M. Aslaner Yael-Natalie H. Escobar Matthew W. Gorr Loren E. Wold Dorothy M. Davis Heart and Lung Research Institute and Department of Physiology and Cell Biology, College of Medicine and Wexner Medical Center, and College of Nursing, Ohio State University, Columbus. Circulation
  Circulation, Volume 145, Issue 11, Page 868-870, March 15, 2022. (Circulation)
• 08:00
  A Pacemaker Red Herring and a Hypertrophic Cardiomyopathy Copycat - Inbar Raber Nicholas O. Palmeri Usman A. Tahir Peter J. Zimetbaum Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Circulation
  Circulation, Volume 145, Issue 8, Page 622-625, February 22, 2022. (Circulation)
• 08:00
  Universal Health Care System and Cardiovascular Disease Burden in Italy - Ciro Indolfi Giovanni Esposito Division of Cardiology, Research Center for Cardiovascular Diseases, University Magna Graecia, Viale Europa, Catanzaro, Italy (C.I.). Mediterranea Cardiocentro, Naples, Italy (C.I.). Division of Cardiology Department of Advanced Biomedical Sciences, University of Naples Federico II, Italy (G.E.). Circulation
  Circulation, Volume 145, Issue 8, Page 559-561, February 22, 2022. (Circulation)
• 08:00
  A Mechanical Bridge to Recovery as a Bridge to Discovery: Learning From Few and Applying to Many - Iosif Taleb Eleni Tseliou James C. Fang Stavros G. Drakos Division of Cardiovascular Medicine (I.T., E.T., J.C.F., S.G.D.), University of Utah Health, Salt Lake City. Nora Eccles Harrison Cardiovascular Research and Training Institute (I.T., E.T., S.G.D.), University of Utah Health, Salt Lake City. Circulation
  Circulation, Volume 145, Issue 8, Page 562-564, February 22, 2022. (Circulation)
• 08:00
  Letter by Wang et al Regarding Article, “HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression” - Fudi Wang Junxia Min Chaodong Ge The Fourth Affiliated Hospital, The First Affiliated Hospital, Institute of Translational Medicine, Cancer Center, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China (F.W.,J.M.,C.G.). The First Affiliated Hospital, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China (F.W.). Circulation
  Circulation, Volume 145, Issue 8, Page e149-e150, February 22, 2022. (Circulation)
• 08:00
  Response by Zhang and Ji to Letter Regarding Article, “HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression” - Yan Zhang Yong Ji Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Key Laboratory of Cardiovascular and Cerebrovascular Medicine (Y.Z., Y.J.), Nanjing Medical University, China. State Key Laboratory of Reproductive Medicine (Y.J.), Nanjing Medical University, China. The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School (Y.J.), Nanjing Medical University, (...) Circulation
  Circulation, Volume 145, Issue 8, Page e151-e152, February 22, 2022. (Circulation)
• 08:00
  Long-Term Efficacy of Colchicine in Patients With Chronic Coronary Disease: Insights From LoDoCo2 - Tjerk S.J. Opstal Amber van Broekhoven Aernoud T.L. Fiolet Arend Mosterd John W. Eikelboom Stefan M. Nidorf Peter L. Thompson Charley A. Budgeon Louis Bartels Ron de Nooijer Willem A. Bax Jan G.P. Tijssen Saloua El Messaoudi Jan H. Cornel Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (T.S.J.O., A.v.B., S.E.M., J.H.C.). Department of Cardiology, Northwest Clinics, Alkmaar, The Netherlands (T.S.J.O., J.H.C.). Department of Cardiology, University Medical Center Utrecht, The Netherlands (A.T.L.F.). Dutch Network for Cardiovascular Research (Werkgroep (...) Circulation
  Circulation, Volume 145, Issue 8, Page 626-628, February 22, 2022. (Circulation)
• 08:00
  Correction to: Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex Circulation
  Circulation, Volume 145, Issue 8, Page e640-e640, February 22, 2022. (Circulation)
• 08:00
  Correction to: Kidney Function After Initiation and Discontinuation of Empagliflozin in Patients With Heart Failure With and Without Type 2 Diabetes: Insights From the EMPERIAL Trials Circulation
  Circulation, Volume 145, Issue 8, Page e641-e641, February 22, 2022. (Circulation)
• 08:00
  From the Literature - Tracy Hampton Circulation
  Circulation, Volume 145, Issue 8, Page 620-621, February 22, 2022. (Circulation)
• 08:00
  New Insights Into the Molecular Underpinnings of LVNC - John D. Mably Joseph C. Wu Da-Zhi Wang University of South Florida Health Heart Institute, Center for Regenerative Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL (J.D.M., D.-Z.W.). Stanford Cardiovascular Institute, Stanford University, Stanford, CA (J.C.W.). Circulation
  Circulation, Volume 145, Issue 8, Page 603-605, February 22, 2022. (Circulation)

17 February

Circulation http://ahajournals.org/

• 08:06
  SPARC, a Novel Regulator of Vascular Cell Function in Pulmonary Hypertension - Christine Veith Ipek Vartürk-Özcan Magdalena Wujak Stefan Hadzic Cheng-Yu Wu Fenja Knoepp Simone Kraut Aleksandar Petrovic Marija Gredic Oleg Pak Monika Brosien Marie Heimbrodt Jochen Wilhelm Friederike C. Weisel Kathrin Malkmus Katharina Schäfer Henning Gall Khodr Tello Djuro Kosanovic Akylbek Sydykov Akpay Sarybaev Andreas Günther Ralf P. Brandes Werner Seeger Friedrich Grimminger Hossein A. Ghofrani Ralph T. Schermuly Grazyna Kwapiszewska Natascha Sommer Norbert Weissmann Excellence Cluster Cardio-Pulmonary Institute, University of Giessen and Marburg Lung Center, Member of the German (...) Circulation
  Circulation, Volume 145, Issue 12, Page 916-933, March 22, 2022. Background:Pulmonary hypertension (PH) is a life-threatening disease, characterized by excessive pulmonary vascular remodeling, leading to elevated pulmonary arterial pressure and right heart hypertrophy. PH can be caused by (...) (Circulation)

15 February

Circulation http://ahajournals.org/

• 08:05
  Elevated MCU Expression by CaMKII?B Limits Pathological Cardiac Remodeling - Pei Wang Shangcheng Xu Jiqian Xu Yanguo Xin Yan Lu Huiliang Zhang Bo Zhou Haodong Xu Shey-Shing Sheu Rong Tian Wang Wang Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine (P.W., S.X., J.X., Y.X., H.Z., B.Z., R.T., W.W.), University of Washington, Seattle. Department of Laboratory Medicine and Pathology (Y.L., H.Z., H.X., W.W.), University of Washington, Seattle. Center for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA (...) Circulation
  Circulation, Volume 145, Issue 14, Page 1067-1083, April 5, 2022. Background:Calcium (Ca2+) is a key regulator of energy metabolism. Impaired Ca2+homeostasis damages mitochondria, causing cardiomyocyte death, pathological hypertrophy, and heart failure. This study investigates the regulation (...) (Circulation)
• 11:00
  Optimizing Outcomes After Out-of-Hospital Cardiac Arrest With Innovative Approaches to Public-Access Defibrillation: A Scientific Statement From the International Liaison Committee on Resuscitation - Steven C. Brooks Gareth R. Clegg Janet Bray Charles D. Deakin Gavin D. Perkins Mattias Ringh Christopher M. Smith Mark S. Link Raina M. Merchant Jaime Pezo-Morales Michael Parr Laurie J. Morrison Tzong-Luen Wang Rudolph W. Koster Marcus E.H. Ong Circulation
  Circulation, Volume 145, Issue 13, Page e776-e801, March 29, 2022. Out-of-hospital cardiac arrest is a global public health issue experienced by ?3.8 million people annually. Only 8% to 12% survive to hospital discharge. Early defibrillation of shockable rhythms is associated with improved (...) (Circulation)

14 February

Circulation http://ahajournals.org/

• 08:00
  Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha–Mediated CD8+ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease - Livia S.A. Passos Prabhash K. Jha Dakota Becker-Greene Mark C. Blaser Dayanna Romero Adrien Lupieri Galina K. Sukhova Peter Libby Sasha A. Singh Walderez O. Dutra Masanori Aikawa Robert A. Levine Maria C.P. Nunes Elena Aikawa Center for Excellence in Vascular Biology (L.S.A.P., P.K.J., D.B.-G., D.R., A.L., G.K.S., P.L., M.A., E.A.), Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. Center for Interdisciplinary Cardiovascular Sciences (M.C.B., S.A.S., M.A., E.A.), Division of Cardiovascular Medicine, Department of (...) Circulation
  Circulation, Volume 145, Issue 7, Page 531-548, February 15, 2022. Background:Rheumatic heart valve disease (RHVD) is a leading cause of cardiovascular death in low- and middle-income countries and affects predominantly women. The underlying mechanisms of chronic valvular damage remain (...) (Circulation)
• 08:00
  Sex Differences in Use and Response to Cardiac Rhythm Management Devices - Anne B. Curtis Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, NY. Circulation
  Circulation, Volume 145, Issue 7, Page 505-506, February 15, 2022. (Circulation)
• 08:00
  Statin Use in Pregnancy: Is It Time For a Paradigm Shift? - Rina Mauricio Amit Khera Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas. Circulation
  Circulation, Volume 145, Issue 7, Page 496-498, February 15, 2022. (Circulation)
• 08:00
  How to Incorporate Sex and Gender Into the Design of Cardiovascular Clinical Trials - Carolyn S.P. Lam National Heart Centre Singapore and Duke–National University of Singapore; and University Medical Centre Groningen, The Netherlands. Circulation
  Circulation, Volume 145, Issue 7, Page 499-501, February 15, 2022. (Circulation)
• 08:00
  Call for Action to Address Increasing Maternal Cardiovascular Mortality in the United States: Strategies for Improving Maternal Cardiovascular Care - Kathryn J. Lindley Cardiovascular Division, Washington University School of Medicine, St. Louis, MO. Circulation
  Circulation, Volume 145, Issue 7, Page 502-504, February 15, 2022. (Circulation)
• 08:00
  Sex Differences in Cardio-Oncology: Considerations for the Practicing Clinician and Researcher - Tochukwu M. Okwuosa Vlad G. Zaha Department of Internal Medicine, Division of Cardiovascular Medicine, Rush University Medical Center, Chicago, IL (T.M.). Department of Internal Medicine, Cardiology Division, Cardio-Oncology Program, Harold C. Simmons Comprehensive Cancer Center, and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas (V.G.Z). Parkland Health and Hospital System, Dallas, TX (V.G.Z). Circulation
  Circulation, Volume 145, Issue 7, Page 510-512, February 15, 2022. (Circulation)
• 08:00
  Shining a Light on the Superwoman Schema and Maternal Health - Rachel M. Bond Annette Ansong Michelle A. Albert Dignity Health, Arizona, Chandler (R.M.B.). Division of Cardiology, Department of Internal Medicine, Creighton University School of Medicine, Omaha, NE (R.M.B.). Division of Cardiology, Children’s National Hospital, Washington, DC (A.A.). Center for the Study of Adversity and Cardiovascular Disease (NURTURE Center), Division of Cardiology, Department of Medicine, University of California, San Francisco School of Medicine (...) Circulation
  Circulation, Volume 145, Issue 7, Page 507-509, February 15, 2022. (Circulation)
• 08:00
  Microvascular Outcomes in Women With a History of Hypertension in Pregnancy - Michael C. Honigberg Seyedeh M. Zekavat Vineet K. Raghu Pradeep Natarajan Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston (M.C.H., P.N.). Cardiovascular Research Center (M.C.H., V.K.R., P.N.), Massachusetts General Hospital, Harvard Medical School, Boston. Cardiovascular Imaging Research Center (V.K.R.), Massachusetts General Hospital, Harvard Medical School, Boston. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA (M.C.H., S.M.Z., V.K.R., P.N.). Computational Biology and Bioinformatics Program, Yale (...) Circulation
  Circulation, Volume 145, Issue 7, Page 552-554, February 15, 2022. (Circulation)
• 08:00
  Spontaneous Coronary Artery Dissection: Insights From Cardiac Magnetic Resonance and Extracoronary Arterial Screening - Emmanuel Androulakis Alessia Azzu Panagiotis Papagkikas Alexios Antonopoulos Abtehale Al-Hussaini Dudley Pennell Raad Mohiaddin Royal Brompton Hospital and Harefield Hospitals, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK (E.A., A.A., P.P., A.A., D.P., R.M.). Department of Cardiology, Chelsea and Westminster Hospital, London, UK (A.A.-H.). National Heart and Lung Institute, Imperial College, London, UK (D.P., R.M.). Circulation
  Circulation, Volume 145, Issue 7, Page 555-557, February 15, 2022. (Circulation)
• 08:00
  Geographic Differences in Prepregnancy Cardiometabolic Health in the United States, 2016 Through 2019 - Natalie A. Cameron Priya M. Freaney Michael C. Wang Amanda M. Perak Brigid M. Dolan Matthew J. O’Brien S. Darius Tandon Matthew M. Davis William A. Grobman Norrina B. Allen Philip Greenland Donald M. Lloyd-Jones Sadiya S. Khan Department of Medicine, Division of Internal Medicine and Geriatrics (N.A.C., M.C.W., B.M.D., M.J.O.), Northwestern University Feinberg School of Medicine, Chicago, IL. Division of Cardiology (P.M.F., P.G., D.M.L.-J., S.S.K.), Northwestern University Feinberg School of Medicine, Chicago, IL. Department of Preventive Medicine (A.M.P., N.B.A., P.G., D.M.L.-J., S.S.K.), (...) Circulation
  Circulation, Volume 145, Issue 7, Page 549-551, February 15, 2022. (Circulation)
• 08:00
  Sixth Annual Go Red for Women Issue - Biykem Bozkurt Joseph A. Hill Sana M. Al-Khatib Winters Center for Heart Failure Research, Cardiovascular Research Institute, Baylor College of Medicine, Michael E. DeBakey VA Medical Center, Houston, TX (B.B.). Departments of Internal Medicine, Cardiology Division, and Molecular Biology, University of Texas Southwestern Medical Center, Dallas (J.A.H.). Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (...) Circulation
  Circulation, Volume 145, Issue 7, Page 489-490, February 15, 2022. (Circulation)
• 08:00
  On the Shoulders of Witnesses: A Conversation With Biykem Bozkurt, MD, PhD - Biykem Bozkurt Maryjane Farr Circulation
  Circulation, Volume 145, Issue 7, Page 491-495, February 15, 2022. (Circulation)

10 February

Circulation http://ahajournals.org/

• 07:15
  Fetal Brain Volume Predicts Neurodevelopment in Congenital Heart Disease - Anjali Sadhwani David Wypij Valerie Rofeberg Ali Gholipour Maggie Mittleman Julia Rohde Clemente Velasco-Annis Johanna Calderon Kevin G. Friedman Wayne Tworetzky P. Ellen Grant Janet S. Soul Simon K. Warfield Jane W. Newburger Cynthia M. Ortinau Caitlin K. Rollins Department of Psychiatry and Behavioral Sciences (A.S., J.C.), Boston Children’s Hospital, MA. Department of Cardiology (D.W., V.R., K.G.F., W.T., J.W.N.), Boston Children’s Hospital, MA. Department of Radiology (A.G., C.V.-A., P.E.G., S.K.W.), Boston Children’s Hospital, MA. Department of Neurology (M.M., J.R., J.S.S., C.K.R.), (...) Circulation
  Circulation, Volume 145, Issue 15, Page 1108-1119, April 12, 2022. Background:Neurodevelopmental impairment is common in children with congenital heart disease (CHD), but postnatal variables explain only 30% of the variance in outcomes. To explore whether the antecedents for neurodevelopmental (...) (Circulation)
• 08:55
  Second Heart Field–Derived Cells Contribute to Angiotensin II–Mediated Ascending Aortopathies - Hisashi Sawada Yuriko Katsumata Hideyuki Higashi Chen Zhang Yanming Li Stephanie Morgan Lang H. Lee Sasha A. Singh Jeff Z. Chen Michael K. Franklin Jessica J. Moorleghen Deborah A. Howatt Debra L. Rateri Ying H. Shen Scott A. LeMaire Masanori Aikawa Mark W. Majesky Hong S. Lu Alan Daugherty Saha Cardiovascular Research Center (H.S., J.Z.C., M.K.F., J.J.M., D.A.H., D.L.R., H.S.L., A.D.), University of Kentucky, Lexington. Saha Aortic Center (H.S., H.S.L., A.D.), University of Kentucky, Lexington. Department of Physiology (H.S., J.Z.C., H.S.L., A.D.), University of Kentucky, Lexington. (...) Circulation
  Circulation, Volume 145, Issue 13, Page 987-1001, March 29, 2022. Background:The ascending aorta is a common location for aneurysm and dissection. This aortic region is populated by a mosaic of medial and adventitial cells that are embryonically derived from either the second heart field (SHF) (...) (Circulation)

9 February

Circulation http://ahajournals.org/

• 11:00
  MRI-Detected Brain Lesions and Cognitive Function in Patients With Atrial Fibrillation Undergoing Left Atrial Catheter Ablation in the Randomized AXAFA-AFNET 5 Trial - Karl Georg Haeusler Felizitas A. Eichner Peter U. Heuschmann Jochen B. Fiebach Tobias Engelhorn Benjamin Blank David Callans Arif Elvan Massimo Grimaldi Jim Hansen Gerhard Hindricks Hussein R. Al-Khalidi Lluis Mont Jens Cosedis Nielsen Jonathan P. Piccini Ulrich Schotten Sakis Themistoclakis Johan Vijgen Luigi Di Biase Paulus Kirchhof Atrial Fibrillation Network (AFNET), Münster, Germany (K.G.H., B.B., U.S., P.K.). Department of Neurology, Universitätsklinikum Würzburg, Germany (K.G.H.). Institute of Clinical Epidemiology and Biometry, University Würzburg, Germany (F.A.E., P.U.H.). Clinical (...) Circulation
  Circulation, Volume 145, Issue 12, Page 906-915, March 22, 2022. Background:We aimed to assess the prevalence of ischemic brain lesions detected by magnetic resonance imaging and their association with cognitive function 3 months after first-time ablation using continuous oral anticoagulation (...) (Circulation)

7 February

Circulation http://ahajournals.org/

• 08:00
  Why Are We Still Prescribing Angiotensin-Converting Enzyme Inhibitors? - Franz H. Messerli Chirag Bavishi Sripal Bangalore Swiss Cardiovascular Center, University of Bern, Switzerland (F.H.M.). Department of Cardiology, Lifespan Cardiovascular Institute, Warren Alpert Medical School at Brown University, Providence, RI (C.B.). NYU Langone Hospitals, New York University School of Medicine (S.B.). Circulation
  Circulation, Volume 145, Issue 6, Page 413-415, February 8, 2022. (Circulation)
• 08:00
  Regular Acetaminophen Use and Blood Pressure in People With Hypertension: The PATH-BP Trial - Iain M. MacIntyre Emma J. Turtle Tariq E. Farrah Catriona Graham James W. Dear David J. Webb Department of Renal Medicine, Royal Infirmary of Edinburgh, National Health Service Lothian, UK (I.M.M., T.E.F.). University/British Heart Foundation Center of Research Excellence, Center for Cardiovascular Science, Queen’s Medical Research Institute (I.M.M., E.J.T., T.E.F., J.W.D., D.J.W.), University of Edinburgh, UK. Edinburgh Clinical Research Facility (C.G.), University of Edinburgh, UK., for the PATH-BP (Paracetamol in Hypertension–Blood Pressure) Investigators* Morag McCallum Vanessa Melville (...) Circulation
  Circulation, Volume 145, Issue 6, Page 416-423, February 8, 2022. Background:Acetaminophen is widely used as first-line therapy for chronic pain because of its perceived safety and the assumption that, unlike nonsteroidal anti-inflammatory drugs, it has little or no effect on blood pressure (...) (Circulation)
• 08:00
  One-Year Major Cardiovascular Events After Restrictive Versus Liberal Blood Transfusion Strategy in Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Trial - Jose R. Gonzalez-Juanatey Gilles Lemesle Etienne Puymirat Gregory Ducrocq Marine Cachanado Joan Albert Arnaiz Manuel Martínez-Sellés Johanne Silvain Albert Ariza-Solé Emile Ferrari Gonzalo Calvo Nicolas Danchin Cristina Avendano-Solá Alexandra Rousseau Eric Vicaut Teba Gonzalez-Ferrero Philippe Gabriel Steg Tabassome Simon Cardiology Department, University Hospital, Health Research Institute of Santiago de Compostela, Centro de Investigación en Red de Enfermedades Cardiovasculares, University of Santiago de Compostela, Spain (J.R.G.-J., T.G.-F.). Institut Cœur Poumon, Centre Hospitalier (...) Circulation
  Circulation, Volume 145, Issue 6, Page 486-488, February 8, 2022. (Circulation)
• 08:00
  Rev-erb–Mediated Regulation of Cardiac Metabolism in the Obesity Paradox - Inna Rabinovich-Nikitin Lorrie A. Kirshenbaum Department of Physiology and Pathophysiology, The Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada (I.R-N., L.A.K.). Department of Pharmacology and Therapeutics, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada (L.A.K.). Circulation
  Circulation, Volume 145, Issue 6, Page 465-468, February 8, 2022. (Circulation)
• 08:00
  Acetaminophen-Induced Hypertension: Where Have All the “Safe” Analgesics Gone? - Steven M. Smith Rhonda M. Cooper-DeHoff Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL. Circulation
  Circulation, Volume 145, Issue 6, Page 424-426, February 8, 2022. (Circulation)

4 February

Circulation http://ahajournals.org/

• 11:00
  lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth - Haobo Li Lena E. Trager Xiaojun Liu Margaret H. Hastings Chunyang Xiao Justin Guerra Samantha To Guoping Li Ashish Yeri Rodosthenis Rodosthenous Michael G. Silverman Saumya Das Amrut V. Ambardekar Michael R. Bristow Juan Manuel González-Rosa Anthony Rosenzweig Corrigan-Minehan Heart Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston (H.L., L.E.T., X.L., M.H.H., C.X., J.G., S.T., G.L., A.Y., R.R., M.G.S., S.D., J.M.G.-R., A.R.). Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora (A.V.A., (...) Circulation
  Circulation, Volume 145, Issue 16, Page 1218-1233, April 19, 2022. Background:The heart grows in response to pathological and physiological stimuli. The former often precedes cardiomyocyte loss and heart failure; the latter paradoxically protects the heart and enhances cardiomyogenesis. The (...) (Circulation)

3 February

Circulation http://ahajournals.org/

• 07:09
  CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells - Guoshuai Feng Geetika Bajpai Pan Ma Andrew Koenig Andrea Bredemeyer Inessa Lokshina Lulu Lai Irmgard Förster Florian Leuschner Daniel Kreisel Kory J. Lavine Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, MO (G.F., G.B., P.M., A.K., A.B., I.L., L.L., K.J.L.). LIMES Institute, University of Bonn, Germany (I.F.). Department of Internal Medicine III, University Hospital Heidelberg, University of Heidelberg, Germany (F.L.). Departments of Surgery (D.K.), Washington University, St Louis, MO. Pathology and Immunology (D.K., K.J.L.), Washington (...) Circulation
  Circulation, Volume 145, Issue 10, Page 765-782, March 8, 2022. Background:Recent studies have established that CCR2 (C-C chemokine receptor type 2) marks proinflammatory subsets of monocytes, macrophages, and dendritic cells that contribute to adverse left ventricle (LV) remodeling and heart (...) (Circulation)
• 07:21
  Patient-Specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunction - Antoinette F. van Ouwerkerk Fernanda M. Bosada Karel van Duijvenboden Arjan C. Houweling Koen T. Scholman Vincent Wakker Cornelis P. Allaart Jae-Sun Uhm Inge B. Mathijssen Ton Baartscheer Alex V. Postma Phil Barnett Arie O. Verkerk Bastiaan J. Boukens Vincent M. Christoffels Department of Medical Biology (A.F.vO., F.M.B., K.vD., K.T.S., V.W., J-S.U., A.V.P., P.B., A.O.V., B.J.B., V.M.C.), University of Amsterdam, The Netherlands. Experimental Cardiology (T.B., A.O.V.), University of Amsterdam, The Netherlands. Department of Cardiology, Vrije Universiteit Amsterdam (C.P.A.), Amsterdam (...) Circulation
  Circulation, Volume 145, Issue 8, Page 606-619, February 22, 2022. Background:The pathogenic missense variant p.G125R in TBX5 (T-box transcription factor 5) causes Holt–Oram syndrome (also known as hand–heart syndrome) and early onset of atrial fibrillation. Revealing how an altered key (...) (Circulation)

31 January

Circulation http://ahajournals.org/

• 11:00
  American Heart Association’s Life’s Simple 7: Lifestyle Recommendations, Polygenic Risk, and Lifetime Risk of Coronary Heart Disease - Natalie R. Hasbani Symen Ligthart Michael R. Brown Adam S. Heath Allison Bebo Kellan E. Ashley Eric Boerwinkle Alanna C. Morrison Aaron R. Folsom David Aguilar Paul S. de Vries Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston (N.R.H., M.R.B., A.S.H., A.B., E.B., A.C.M., P.S.d.V). Department of Epidemiology and Adult Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands (S.L.). Departments of Interventional Cardiovascular Disease and (...) Circulation
  Circulation, Volume 145, Issue 11, Page 808-818, March 15, 2022. Background:Understanding the effect of lifestyle and genetic risk on the lifetime risk of coronary heart disease (CHD) is important to improving public health initiatives. Our objective was to quantify remaining lifetime risk and (...) (Circulation)
• 12:51
  Legumain Is an Endogenous Modulator of Integrin ?v?3 Triggering Vascular Degeneration, Dissection, and Rupture - Lihong Pan Peiyuan Bai Xinyu Weng Jin Liu Yingjie Chen Siqin Chen Xiurui Ma Kai Hu Aijun Sun Junbo Ge Institutes of Biomedical Sciences, Fudan University, Shanghai, China (L.P., S.C., A.S., J.G.). Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, China (P.B., X.W., J.L., X.M., K.H., A.S., J.G.). Key Laboratory of Viral Heart Diseases, National Health Commission, Shanghai, China (L.P., P.B., X.W., J.L., S.C., X.M., A.S., J.G.). Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China (L.P., (...) Circulation
  Circulation, Volume 145, Issue 9, Page 659-674, March 1, 2022. Background:The development of thoracic aortic dissection (TAD) is closely related to extracellular matrix degradation and vascular smooth muscle cell (VSMC) transformation from contractile to synthetic type. LGMN (legumain) degrades (...) (Circulation)
• 08:00
  Salt-Induced Hepatic Inflammatory Memory Contributes to Cardiovascular Damage Through Epigenetic Modulation of SIRT3 - Peng Gao Mei You Li Li Qin Zhang Xia Fang Xiao Wei Qing Zhou Hexuan Zhang Miao Wang Zongshi Lu Lijuan Wang Fang Sun Daoyan Liu Hongting Zheng Zhencheng Yan Gangyi Yang Zhiming Zhu Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Daping Hospital, Chongqing Institute of Hypertension (P.G., M.Y., L.L., X.W., Q. Zhou, H.Z., Z.L., L.W., F.S., D.L., Z.Y., Z.Z.), Army Medical University, Chongqing China. Department of Endocrinology, Translational Research Key Laboratory for Diabetes, Xinqiao Hospital (H.Z.), Army Medical University, Chongqing China. (...) Circulation
  Circulation, Volume 145, Issue 5, Page 375-391, February 1, 2022. Background:High salt intake is the leading dietary risk factor for cardiovascular diseases. Although clinical evidence suggests that high salt intake is associated with nonalcoholic fatty liver disease, which is an independent (...) (Circulation)
• 08:00
  Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration - Léna Rivard Leif Friberg David Conen Jeffrey S. Healey Trygve Berge Giuseppe Boriani Axel Brandes Hugh Calkins A. John Camm Lin Yee Chen Josep Lluis Clua Espuny Ronan Collins Stuart Connolly Nikolaos Dagres Mitchell S.V. Elkind Johan Engdahl Thalia S. Field Bernard J. Gersh Taya V. Glotzer Graeme J. Hankey Joseph A. Harbison Karl Georg Haeusler Mellanie T. Hills Linda S.B. Johnson Boyoung Joung Paul Khairy Paulus Kirchhof Derk Krieger Gregory Y.H. Lip Maja-Lisa Løchen Malini Madhavan Georges H. Mairesse Joan Montaner George Ntaios Terence J. Quinn Michiel Rienstra Mårten Rosenqvist Roopinder (...) Circulation
  Circulation, Volume 145, Issue 5, Page 392-409, February 1, 2022. Growing evidence suggests a consistent association between atrial fibrillation (AF) and cognitive impairment and dementia that is independent of clinical stroke. This report from the AF-SCREEN International Collaboration (...) (Circulation)
• 08:00
  Thirty Years of No-Touch Saphenous Vein Harvesting: A Timely Jubilee Gift - Michael R. Dashwood Bruno Botelho Pinheiro Domingos S.R. Souza Surgical and Interventional Sciences, Royal Free Hospital Campus, University College London Medical School, United Kingdom (M.R.D.). Department of Cardiovascular Surgery, Hospital do Coração Anis Rassi, Goiânia, Goiás, Brazil (B.B.P.). Department of Cardiothoracic and Vascular Surgery, Faculty of Medicine and Health, Örebro University, Sweden (D.S.R.S.). Circulation
  Circulation, Volume 145, Issue 5, Page 319-320, February 1, 2022. (Circulation)
• 08:00
  Letter by Enas and Varkey Regarding Article, “Quantifying and Understanding the Higher Risk of Atherosclerotic Cardiovascular Disease Among South Asian Individuals: Results From the UK Biobank Prospective Cohort Study” - Enas A. Enas Basil Varkey Coronary Artery Disease Among Asian Indians (CADI) Research Foundation, Lisle, IL. Circulation
  Circulation, Volume 145, Issue 5, Page e146-e146, February 1, 2022. (Circulation)
• 08:00
  Response by Patel and Khera to Letter Regarding Article, “Quantifying and Understanding the Higher Risk of Atherosclerotic Cardiovascular Disease Among South Asian Individuals: Results From the UK Biobank Prospective Cohort Study” - Aniruddh P. Patel Amit V. Khera Center for Genomic Medicine and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge. Harvard Medical School, Boston, MA. Circulation
  Circulation, Volume 145, Issue 5, Page e147-e148, February 1, 2022. (Circulation)
• 08:00
  Genetic Proliferation Tracing Reveals a Rapid Cell Cycle Withdrawal in Preadolescent Cardiomyocytes - Wenjuan Pu Mingjun Zhang Xiuxiu Liu Lingjuan He Jie Li Ximeng Han Kathy O. Lui Ben He Bin Zhou State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China (W.P., M.Z., X.L., L.H., J.L., X.H., B.Z.). School of Life Sciences, Westlake University, Hangzhou, China (L.H.). Department of Chemical Pathology; and Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, China (K.O.L.). (...) Circulation
  Circulation, Volume 145, Issue 5, Page 410-412, February 1, 2022. (Circulation)
• 08:00
  The Power of Patient Stories to Inspire Us to Prevent Cardiovascular Disease and Death: Personal Reflections on the AHA’s Scientific Sessions 2021 - Donald M. Lloyd-Jones Departments of Preventive Medicine, Medicine, and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL. Circulation
  Circulation, Volume 145, Issue 5, Page e143-e145, February 1, 2022. (Circulation)
• 08:00
  Linking Genetics and Proteomics: Gene-Protein Associations Built on Diversity - Heribert Schunkert Manuel Mayr Department of Cardiology, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany (H.S.). Deutsches Zentrum für Herz- und Kreislauferkrankungen, Partner Site Munich Heart Alliance, Munich, Germany (H.S.). King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences, United Kingdom (M.M.). Circulation
  Circulation, Volume 145, Issue 5, Page 371-374, February 1, 2022. (Circulation)
• 08:00
  Perplexing Results From the PRAETORIAN Trial: Revisiting the Debate About the Value of Antitachycardia Pacing - Sana M. Al-Khatib Mark S. Link Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (S.M.A.-K.). Cardiac Electrophysiology, University of Texas Southwestern Medical Center, Dallas (M.S.L.). Circulation
  Circulation, Volume 145, Issue 5, Page 330-332, February 1, 2022. (Circulation)

28 January

Circulation http://ahajournals.org/

• 08:24
  In Vitro Matured Human Pluripotent Stem Cell–Derived Cardiomyocytes Form Grafts With Enhanced Structure and Function in Injured Hearts - Wahiba Dhahri Tamilla Sadikov Valdman Dan Wilkinson Elizabeth Pereira Eylül Ceylan Naaz Andharia Beiping Qiang Hassan Masoudpour Fanny Wulkan Elya Quesnel Wenlei Jiang Shunsuke Funakoshi Amine Mazine M. Juliana Gomez-Garcia Neda Latifi Yidi Jiang Ella Huszti Craig A. Simmons Gordon Keller Michael A. Laflamme McEwen Stem Cell Institute (W.D., T.S.V., E.C., N.A., B.Q., H.M., F.W., E.Q., W.J., S.F., A.M., M.J.G.-G., G.K., M.A.L.), University Health Network, Toronto, ON, Canada. Biostatistics Research Unit (Y.J., E.H.), University Health Network, Toronto, ON, Canada. Peter Munk Cardiac Centre (...) Circulation
  Circulation, Volume 145, Issue 18, Page 1412-1426, May 3, 2022. Background:Human pluripotent stem cell (hPSC)–derived cardiomyocytes (hPSC-CMs) have tremendous promise for application in cardiac regeneration, but their translational potential is limited by an immature phenotype. We hypothesized (...) (Circulation)

26 January

Circulation http://ahajournals.org/

• 06:44
  Heart Xenotransplant: A Door That Is Finally Opening - Maryjane Farr Josef Stehlik Division of Cardiovascular Medicine, University of Texas Southwestern Medical Center, Dallas (M.F.). Division of Cardiovascular Medicine, University of Utah, Salt Lake City (J.S.). Circulation
  Circulation, Volume 145, Issue 12, Page 871-873, March 22, 2022. (Circulation)
• 11:00
  Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association - Connie W. Tsao Aaron W. Aday Zaid I. Almarzooq Alvaro Alonso Andrea Z. Beaton Marcio S. Bittencourt Amelia K. Boehme Alfred E. Buxton April P. Carson Yvonne Commodore-Mensah Mitchell S.V. Elkind Kelly R. Evenson Chete Eze-Nliam Jane F. Ferguson Giuliano Generoso Jennifer E. Ho Rizwan Kalani Sadiya S. Khan Brett M. Kissela Kristen L. Knutson Deborah A. Levine Tené T. Lewis Junxiu Liu Matthew Shane Loop Jun Ma Michael E. Mussolino Sankar D. Navaneethan Amanda Marma Perak Remy Poudel Mary Rezk-Hanna Gregory A. Roth Emily B. Schroeder Svati H. Shah Evan L. Thacker Lisa B. VanWagner Salim S. (...) Circulation
  Circulation, Volume 145, Issue 8, Page e153-e639, February 22, 2022. Background:The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including (...) (Circulation)

24 January

Circulation http://ahajournals.org/

• 08:00
  Letter by Costantine et al Regarding Article, “Pravastatin Versus Placebo in Pregnancies at High Risk of Term Preeclampsia” - Maged M. Costantine Kirsten Lawrence-Cleary Georges Saade Ronald J. Wapner Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus (M.M.C.). Department of Obstetrics and Gynecology, Yale University, New Haven, CT (K.L.-C.). Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston (G.S.). Department of Obstetrics and Gynecology, Columbia University, New York, NY (R.J.W.). Circulation
  Circulation, Volume 145, Issue 4, Page e115-e116, January 25, 2022. (Circulation)
• 08:00
  Multifaceted Spatial and Functional Zonation of Cardiac Cells in Adult Human Heart - Liang Chen Kui Hua Ningning Zhang Jingyu Wang Jian Meng Zhenliang Hu Haoxiang Gao Fanhong Li Yang Chen Jie Ren Liyang Liu Qiming Zhou Jin Gu Jiangping Song Xuegong Zhang Shengshou Hu State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.C., N.Z., J.M., Z.H., J.R., J.S., S.H.). MOE Key Laboratory of Bioinformatics, Bioinformatics Division, Beijing National Research Center for Information Science and Technology and Department of Automation (K.H., (...) Circulation
  Circulation, Volume 145, Issue 4, Page 315-318, January 25, 2022. (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 145, Issue 4, Page 309-314, January 25, 2022. (Circulation)
• 08:00
  A Patient-Level Meta-Analysis: The End of the Era of Direct Oral Anticoagulant Developmental Trials in Patients With Atrial Fibrillation? - Shinya Goto Shinichi Goto Department of Medicine (Cardiology), Tokai University School of Medicine, Isehara, Japan. Circulation
  Circulation, Volume 145, Issue 4, Page 256-258, January 25, 2022. (Circulation)
• 08:00
  Preventing Anthracycline-Induced Cardiotoxicity Using Functional Genomics and Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes - Valentina Lo Sardo Timothy J. Kamp Department of Cell and Regenerative Biology (V.LS., T.J.K.), University of Wisconsin-Madison. Stem Cell and Regenerative Medicine Center (V.LS., T.J.K.), University of Wisconsin-Madison. Department of Medicine (T.J.K.), University of Wisconsin-Madison. Circulation
  Circulation, Volume 145, Issue 4, Page 295-298, January 25, 2022. (Circulation)
• 08:00
  The Clinical Impact of Device Lead–Associated Tricuspid Regurgitation: Need for a Multidisciplinary Approach - Aviral Vij Clifford J. Kavinsky Division of Cardiology, Cook County Health, Chicago, IL (A.V.). Division of Cardiology, Rush Medical College, Chicago, IL (A.V., C.J.K.). Circulation
  Circulation, Volume 145, Issue 4, Page 239-241, January 25, 2022. (Circulation)

21 January

Circulation http://ahajournals.org/

• 07:21
  Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure - Riham R.E. Abouleisa Abou Bakr M. Salama Qinghui Ou Xian-Liang Tang Mitesh Solanki Yiru Guo Yibing Nong Lindsey McNally Pawel K. Lorkiewicz Kamal M. Kassem Brooke M. Ahern Krishna Choudhary Reuben Thomas Yu Huang Hamzah R. Juhardeen Aisha Siddique Zainab Ifthikar Sally K. Hammad Ayman S. Elbaz Kathryn N. Ivey Daniel J. Conklin Jonathan Satin Bradford G. Hill Deepak Srivastava Roberto Bolli Tamer M.A. Mohamed From the Institute of Molecular Cardiology (R.R.E.A., A.B.M.S., Q.O., X.-L.T., M.S., Y.G., Y.N., K.M.K., S.K.H., R.B., T.M.A.M.), University of Louisville, KY. Envirome Institute, (...) Circulation
  Circulation, Volume 145, Issue 17, Page 1339-1355, April 26, 2022. Background:The regenerative capacity of the heart after myocardial infarction is limited. Our previous study showed that ectopic introduction of 4 cell cycle factors (4F; CDK1 [cyclin-dependent kinase 1], CDK4 [cyclin-dependent (...) (Circulation)

20 January

Circulation http://ahajournals.org/

• 09:52
  Circulating Metabolome and White Matter Hyperintensities in Women and Men - Eeva Sliz Jean Shin Shahzad Ahmad Dylan M. Williams Stefan Frenzel Friederike Gauß Sarah E. Harris Ann-Kristin Henning Maria Valdes Hernandez Yi-Han Hu Beatriz Jiménez Muralidharan Sargurupremraj Carole Sudre Ruiqi Wang Katharina Wittfeld Qiong Yang Joanna M. Wardlaw Henry Völzke Meike W. Vernooij Jonathan M. Schott Marcus Richards Petroula Proitsi Matthias Nauck Matthew R. Lewis Lenore Launer Norbert Hosten Hans J. Grabe Mohsen Ghanbari Ian J. Deary Simon R. Cox Nishi Chaturvedi Josephine Barnes Jerome I. Rotter Stephanie Debette M. Arfan Ikram Myriam Fornage Tomas Paus Sudha Seshadri (...) Circulation
  Circulation, Volume 145, Issue 14, Page 1040-1052, April 5, 2022. Background:White matter hyperintensities (WMH), identified on T2-weighted magnetic resonance images of the human brain as areas of enhanced brightness, are a major risk factor of stroke, dementia, and death. There are no (...) (Circulation)
• 08:16
  Association Between Endovascular Therapy Time to Treatment and Outcomes in Patients With Basilar Artery Occlusion - Raed A. Joundi Jie-Lena Sun Ying Xian Brooke Alhanti Raul G. Nogueira Deepak L. Bhatt Gregg C. Fonarow Jeffrey Saver Lee H. Schwamm Eric E. Smith Department of Clinical Neurosciences (R.A.J., E.E.S.), University of Calgary, Canada. Hotchkiss Brain Institute (E.E.S.), University of Calgary, Canada. Division of Neurology, Hamilton Health Sciences, McMaster University & Population Health Research Institute, Canada (R.A.J.). Duke Clinical Research Center, Durham, NC (J.-L.S., B.A.). Marcus Stroke & Neuroscience Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, GA (...) Circulation
  Circulation, Volume 145, Issue 12, Page 896-905, March 22, 2022. Background:Basilar artery occlusion (BAO) is a devastating condition without definitive evidence to guide treatment. Whereas the association between faster treatment times with endovascular therapy (EVT) and better outcomes in (...) (Circulation)

19 January

Circulation http://ahajournals.org/

• 07:23
  Cost-Effectiveness of Coronary Artery Bypass Surgery Versus Medicine in Ischemic Cardiomyopathy: The STICH Randomized Clinical Trial - Derek S. Chew Patricia A. Cowper Hussein Al-Khalidi Kevin J. Anstrom Melanie R. Daniels Linda Davidson-Ray Yanhong Li Robert E. Michler Julio A. Panza Ileana L. Piña Jean L. Rouleau Eric J. Velazquez Daniel B. Mark Duke Clinical Research Institute (D.S.C., P.A.C., H.A., K.J.A., M.R.D., L.D.-R., Y.L., D.B.M.), Duke University, Durham, NC. Department of Biostatistics and Bioinformatics (H.A., K.J.A.), Duke University, Durham, NC. Department of Cardiac Sciences, Libin Cardiovascular Institute (D.S.C.), University of Calgary, Alberta, Canada. O’Brien Institute for Public Health (D.S.C.), (...) Circulation
  Circulation, Volume 145, Issue 11, Page 819-828, March 15, 2022. Background:The STICH Randomized Clinical Trial (Surgical Treatment for Ischemic Heart Failure) demonstrated that coronary artery bypass grafting (CABG) reduced all-cause mortality rates out to 10 years compared with medical (...) (Circulation)

18 January

Circulation http://ahajournals.org/

• 08:00
  E-Cigarettes and Cardiopulmonary Health: Review for Clinicians - Evan W. Neczypor Matthew J. Mears Arunava Ghosh M. Flori Sassano Richard J. Gumina Loren E. Wold Robert Tarran Colleges of Nursing and Medicine (E.W.N., M.J.M., L.E.W.), The Ohio State University, Columbus. Dorothy M. Davis Heart and Lung Research Institute, Department of Physiology and Cell Biology, College of Medicine (E.W.N., M.J.M., L.E.W.), The Ohio State University, Columbus. Department of Cell Biology and Physiology, The University of North Carolina, Chapel Hill (A.G., M.F.S., R.T.). Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University (...) Circulation
  Circulation, Volume 145, Issue 3, Page 219-232, January 18, 2022. Electronic cigarettes (e-cigarettes) are battery powered electronic nicotine delivery systems that use a propylene glycol/vegetable glycerin base to deliver vaporized nicotine and flavorings to the body. E-cigarettes became (...) (Circulation)
• 08:00
  From the Literature - Tracy Hampton Circulation
  Circulation, Volume 145, Issue 3, Page 233-234, January 18, 2022. (Circulation)

17 January

Circulation http://ahajournals.org/

• 11:00
  Myocardial Rev-erb–Mediated Diurnal Metabolic Rhythm and Obesity Paradox - Shiyang Song Chih-Liang Tien Hao Cui Paul Basil Ningxia Zhu Yingyun Gong Wenbo Li Hui Li Qiying Fan Jong Min Choi Weijia Luo Yanfeng Xue Rui Cao Wenjun Zhou Andrea R. Ortiz Brittany Stork Vatsala Mundra Nagireddy Putluri Brian York Maoping Chu Jiang Chang Sung Yun Jung Liang Xie Jiangping Song Lilei Zhang Zheng Sun Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism (S.S., P.B., N.Z., Y.G., W. Li, Y.X., R.C., W.Z., V.M., Z.S.), Baylor College of Medicine, Houston, TX. Department of Molecular and Human Genetics (C.-L.T., H.L., L.Z.), Baylor College of Medicine, (...) Circulation
  Circulation, Volume 145, Issue 6, Page 448-464, February 8, 2022. Background:The nuclear receptor Rev-erb?/?, a key component of the circadian clock, emerges as a drug target for heart diseases, but the function of cardiac Rev-erb has not been studied in vivo. Circadian disruption is implicated (...) (Circulation)

10 January

Circulation http://ahajournals.org/

• 11:00
  Comprehensive Management of Cardiovascular Risk Factors for Adults With Type 2 Diabetes: A Scientific Statement From the American Heart Association - Joshua J. Joseph Prakash Deedwania Tushar Acharya David Aguilar Deepak L. Bhatt Deborah A. Chyun Katherine E. Di Palo Sherita H. Golden Laurence S. Sperling Circulation
  Circulation, Volume 145, Issue 9, Page e722-e759, March 1, 2022. Cardiovascular disease remains the leading cause of death in patients with diabetes. Cardiovascular disease in diabetes is multifactorial, and control of the cardiovascular risk factors leads to substantial reductions in (...) (Circulation)
• 11:00
  Genes That Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts - Brian A. Aguado Cierra J. Walker Joseph C. Grim Megan E. Schroeder Dilara Batan Brandon J. Vogt Andrea Gonzalez Rodriguez Jessica A. Schwisow Karen S. Moulton Robert M. Weiss Donald D. Heistad Leslie A. Leinwand Kristi S. Anseth Department of Chemical and Biological Engineering (B.A.A., J.C.G., B.J.V., A.G.R., K.S.A.), University of Colorado, Boulder. BioFrontiers Institute (B.A.A., J.C.G., M.E.S., D.B., A.G.R., L.A.L., K.S.A.), University of Colorado, Boulder. Materials Science and Engineering Program (C.J.W., M.E.S., K.S.A.), University of Colorado, Boulder. Department of Biochemistry (...) Circulation
  Circulation, Volume 145, Issue 7, Page 513-530, February 15, 2022. Background:Aortic valve stenosis is a sexually dimorphic disease, with women often presenting with sustained fibrosis and men with more extensive calcification. However, the intracellular molecular mechanisms that drive these (...) (Circulation)
• 08:00
  Bidirectional Changes in Myocardial 18F-Fluorodeoxyglucose Uptake After Human Ventricular Unloading - Tiberiu A. Pana Jainy Savla Ingrid Kepinski Adam Fairbourn Aneela Afzal Pradeep Mammen Mark Drazner Rathan M. Subramaniam Chao Xing Kathryn A. Morton Stavros G. Drakos Vlad G. Zaha Hesham A. Sadek Aberdeen Cardiovascular and Diabetes Centre, University of Aberdeen, United Kingdom (T.A.P.). Department of Internal Medicine/Cardiology, University of Washington, Seattle (J.S.). Cardiology Division, Department of Internal Medicine (T.A.P., I.K., A.A., P.M., M.D., V.G.Z., H.A.S.); Department of Radiology (A.F., R.M.S.); Eugene McDermott Center for Human Growth and Development (C.X.); Department (...) Circulation
  Circulation, Volume 145, Issue 2, Page 151-154, January 11, 2022. (Circulation)
• 08:00
  Validation of Blood Pressure Device Accuracy: When the Bottom Line Is Not Enough - Jordana B. Cohen Tammy M. Brady Renal-Electrolyte and Hypertension Division (J.B.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. Department of Biostatistics, Epidemiology, and Informatics (J.B.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. Division of Pediatric Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD (T.M.B.). Circulation
  Circulation, Volume 145, Issue 2, Page 94-96, January 11, 2022. (Circulation)
• 08:00
  Celebrating The Next Generation of Cardiovascular Investigators - James A. de Lemos Darren K. McGuire Joseph A. Hill University of Texas Southwestern Medical Center, Dallas (J.A.d.L., D.K.M., J.A.H.). Parkland Health and Hospital System, Dallas, TX (D.K.M.). Circulation
  Circulation, Volume 145, Issue 2, Page 91-93, January 11, 2022. (Circulation)
• 08:00
  The Evolution of Evidence-Based Medicine: When the Magic of the Randomized Clinical Trial Meets Real-World Data - Seng Chan You Harlan M. Krumholz Department of Preventive Medicine, Yonsei University, College of Medicine, Seoul, Korea (S.C.Y.). Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT (H.M.K.). Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT (H.M.K.). Department of Health Policy and Management, Yale School of Public Health, New Haven, CT (H.M.K.). Circulation
  Circulation, Volume 145, Issue 2, Page 107-109, January 11, 2022. (Circulation)

7 January

Circulation http://ahajournals.org/

• 05:06
  Common Ancestry-Specific Ion Channel Variants Predispose to Drug-Induced Arrhythmias - Yuko Wada Tao Yang Christian M. Shaffer Laura L. Daniel Andrew M. Glazer Giovanni E. Davogustto Brandon D. Lowery Eric H. Farber-Eger Quinn S. Wells Dan M. Roden Department of Medicine (Y.W., T.Y., C.M.S., L.L.D., A.M.G., G.E.D.), Vanderbilt University Medical Center, Nashville, TN. Vanderbilt Institute for Clinical and Translational Research (B.D.L., E.H.F.-E.), Vanderbilt University Medical Center, Nashville, TN. Departments of Medicine, Pharmacology, and Biomedical Informatics (Q.S.W., D.M.R.), Vanderbilt University Medical Center, Nashville, (...) Circulation
  Circulation, Volume 145, Issue 4, Page 299-308, January 25, 2022. Background:Multiple reports associate the cardiac sodium channel gene (SCN5A) variants S1103Y and R1193Q with type 3 congenital long QT syndrome and drug-induced long QT syndrome. These variants are too common in ancestral (...) (Circulation)

6 January

Circulation http://ahajournals.org/

• 10:27
  ZEB2 Shapes the Epigenetic Landscape of Atherosclerosis - Paul Cheng Robert C. Wirka Lee Shoa Clarke Quanyi Zhao Ramendra Kundu Trieu Nguyen Surag Nair Disha Sharma Hyun-jung Kim Huitong Shi Themistocles Assimes Juyong Brian Kim Anshul Kundaje Thomas Quertermous Division of Cardiovascular Medicine and the Cardiovascular Institute, Stanford, CA (P.C., L.S.C., Q.Z., R.K., T.N., D.S., H.-j.K., H.S., T.A., J.B.K., T.Q.). Division of Cardiology, Departments of Medicine and Cell Biology and Physiology, McAllister Heart Institute, University of North Carolina, Chapel Hill (R.C.W.). Department of Genetics, Stanford University School of Medicine, CA (...) Circulation
  Circulation, Volume 145, Issue 6, Page 469-485, February 8, 2022. Background:Smooth muscle cells (SMCs) transition into a number of different phenotypes during atherosclerosis, including those that resemble fibroblasts and chondrocytes, and make up the majority of cells in the atherosclerotic (...) (Circulation)

5 January

Circulation http://ahajournals.org/

• 03:25
  Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex - Anthony P. Carnicelli Hwanhee Hong Stuart J. Connolly John Eikelboom Robert P. Giugliano David A. Morrow Manesh R. Patel Lars Wallentin John H. Alexander M. Cecilia Bahit Alexander P. Benz Erin A. Bohula Tze-Fan Chao Leanne Dyal Michael Ezekowitz Keith A.A. Fox Baris Gencer Jonathan L. Halperin Ziad Hijazi Stefan H. Hohnloser Kaiyuan Hua Elaine Hylek Eri Toda Kato Julia Kuder Renato D. Lopes Kenneth W. Mahaffey Jonas Oldgren Jonathan P. Piccini Christian T. Ruff Jan Steffel Daniel Wojdyla Christopher B. Granger Division of Cardiology (A.P.C., M.R.P., J.H.A., R.D.L., J.P.P., C.B.G.), Duke (...) Circulation
  Circulation, Volume 145, Issue 4, Page 242-255, January 25, 2022. Background:Direct oral anticoagulants (DOACs) are preferred over warfarin for stroke prevention in atrial fibrillation. Meta-analyses using individual patient data offer substantial advantages over study-level data.Methods:We (...) (Circulation)

29 December

Circulation http://ahajournals.org/

• 08:00
  Colchicine in Cardiovascular Disease: In-Depth Review - Spyridon G. Deftereos Frans J. Beerkens Binita Shah George Giannopoulos Dimitrios A. Vrachatis Sotiria G. Giotaki Gerasimos Siasos Johny Nicolas Clare Arnott Sanjay Patel Mark Parsons Jean-Claude Tardif Jason C. Kovacic George D. Dangas Medical School, National Kapodistrian University of Athens, Greece (S.G.D., D.A.V., S.G.G., G.S., G.D.D.). Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, New York (F.J.B., J.N., J.C.K., G.D.D.). VA New York Harbor Healthcare System, New York University School of Medicine, New York (B.S.). Medical School, Aristotelian University, (...) Circulation
  Circulation, Volume 145, Issue 1, Page 61-78, January 4, 2022. Inflammation plays a prominent role in the development of atherosclerosis and other cardiovascular diseases, and anti-inflammatory agents may improve cardiovascular outcomes. For years, colchicine has been used as a safe and (...) (Circulation)
• 08:00
  Dancing Bundles With Stable Sinus Rhythm - Jaya Batra Angelo Biviano Hirad Yarmohammadi Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY. Circulation
  Circulation, Volume 145, Issue 1, Page 84-86, January 4, 2022. (Circulation)
• 08:00
  Expanding the Role of Coronary Computed Tomography Angiography in Interventional Cardiology - Luiz F. Ybarra Nicolo Piazza London Health Sciences Centre, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada (L.F.Y.). Department of Medicine, Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (N.P.). Circulation
  Circulation, Volume 145, Issue 1, Page 5-7, January 4, 2022. (Circulation)
• 08:00
  Policy Change Needed to Improve Maternal Cardiovascular Health - Keith Churchwell Donald M. Lloyd-Jones Suzette Rochat Harris Laxmi S. Mehta Yale New Haven Hospital New Haven, CT (K.C.). Department of Preventive Medicine, Northwestern University, Chicago, IL (D.M.L-J.). American Heart Association, Dallas, TX (S.R.H.). Division of Cardiology, The Ohio State University Wexner Medical Center, Columbus, OH (L.S.M.). Circulation
  Circulation, Volume 145, Issue 1, Page e1-e3, January 4, 2022. (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 145, Issue 1, Page 79-83, January 4, 2022. (Circulation)
• 08:00
  Circulation Editors and Editorial Board Circulation
  Circulation, Volume 145, Issue 1, Page 1-3, January 4, 2022. (Circulation)
• 08:00
  Continued Refinement of the Treatment for Light-Chain Cardiac Amyloidosis - Justin L. Grodin Larry D. Anderson Ankit Kansagra Divisions of Cardiology (J.L.G.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas. Hematology and Oncology (L.D.A., A.K.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas. Circulation
  Circulation, Volume 145, Issue 1, Page 18-20, January 4, 2022. (Circulation)

22 December

Circulation http://ahajournals.org/

• 11:00
  Association Between Age and Outcomes of Catheter Ablation Versus Medical Therapy for Atrial Fibrillation: Results From the CABANA Trial - Tristram D. Bahnson Anna Giczewska Daniel B. Mark Andrea M. Russo Kristi H. Monahan Hussein R. Al-Khalidi Adam P. Silverstein Jeanne E. Poole Kerry L. Lee Douglas L. Packer Duke Clinical Research Institute, Duke University, Durham, NC (T.D.B., A.G., D.B.M., H.R.A.-K., A.P.S., K.L.L.). Duke Center for Atrial Fibrillation, Duke Health System, Durham, NC (T.D.B.). Cooper University Health System, Camden, NJ (A.M.R.). Mayo Clinic, Rochester, MN (K.H.M., D.L.P.). University of Washington Medical Center, Seattle (...) Circulation
  Circulation, Volume 145, Issue 11, Page 796-804, March 15, 2022. Background:Observational data suggest that catheter ablation may be safe and effective to treat younger and older patients with atrial fibrillation. No large, randomized trial has examined this issue. This report describes (...) (Circulation)

21 December

Circulation http://ahajournals.org/

• 11:00
  Arrhythmia Variant Associations and Reclassifications in the eMERGE-III Sequencing Study - Andrew M. Glazer Giovanni Davogustto Christian M. Shaffer Carlos G. Vanoye Reshma R. Desai Eric H. Farber-Eger Ozan Dikilitas Ning Shang Jennifer A. Pacheco Tao Yang Ayesha Muhammad Jonathan D. Mosley Sara L. Van Driest Quinn S. Wells Lauren Lee Shaffer Olivia R. Kalash Yuko Wada Sarah Bland Zachary T. Yoneda Devyn W. Mitchell Brett M. Kroncke Iftikhar J. Kullo Gail P. Jarvik Adam S. Gordon Eric B. Larson Teri A. Manolio Tooraj Mirshahi Jonathan Z. Luo Daniel Schaid Bahram Namjou Tarek Alsaied Rajbir Singh Ashutosh Singhal Cong Liu Chunhua Weng George Hripcsak James D. Ralston Elizabeth (...) Circulation
  Circulation, Volume 145, Issue 12, Page 877-891, March 22, 2022. Background:Sequencing Mendelian arrhythmia genes in individuals without an indication for arrhythmia genetic testing can identify carriers of pathogenic or likely pathogenic (P/LP) variants. However, the extent to which these (...) (Circulation)
• 06:48
  Correction to: Abstract 10712: Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning Circulation
  Circulation, Ahead of Print. (Circulation)

20 December

Circulation http://ahajournals.org/

• 08:32
  Recognized Outstanding Reviewers for Circulation in 2021 - Darren K. McGuire James A. de Lemos Joseph A. Hill University of Texas Southwestern Medical Center, Dallas (D.K.M., J.A.d.L., J.A.H.). Parkland Health and Hospital System, Dallas, TX (D.K.M.)., Eloisa Arbustini Emelia Benjamin Michael Blaha Barry Borlaug Khadijah Breathett Robert Byrne Alida Caforio Edina Cenko Richard Cheng David Cohen Nancy Cook Leslie Cooper Kieran Docherty John Eikelboom Assam El-Osta Eva Gerdts Bruna Gigante Robert Giugliano Shinichi Goto Christopher Granger Ziad Hijaz Mark Hlatky Michael Holmes Priscilla Hsue Sadiya Khan Susan Kwon Gregory Lewis Douglas Mann Erin (...) Circulation
  Circulation, Volume 145, Issue 1, Page 4-4, January 4, 2022. (Circulation)
• 08:00
  Wide Complex Tachycardia and Syncope in the Emergency Department - Andrés F. Miranda-Arboleda Shireen Mohammad Adrian Baranchuk Division of Cardiology, Kingston Health Science Centre, Queen’s University, Kingston, ON, Canada (A.F.M.-A., S.M., A.B.). Cardiology Department, Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia (A.F.M.-A.). Circulation
  Circulation, Volume 144, Issue 25, Page 2040-2042, December 21, 2021. (Circulation)
• 08:00
  Late-Breaking Science Abstracts and Featured Science Abstracts From the American Heart Association's Scientific Sessions 2021 and Late-Breaking Abstracts in Resuscitation Science From the Resuscitation Science Symposium 2021 Circulation
  Circulation, Volume 144, Issue 25, Page e564-e593, December 21, 2021. (Circulation)
• 08:00
  Liver Cirrhosis and Hepatocellular Carcinoma After the Fontan Operation: Reaching Clarity in the Face of Uncertainty - Christopher Z. Lam Aliya Gulamhusein Rachel M. Wald Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON, Canada (C.Z.L.). Toronto Centre for Liver Disease (A.G.), Toronto General Hospital, ON, Canada. Peter Munk Cardiac Centre (R.M.W.), Toronto General Hospital, ON, Canada. Circulation
  Circulation, Volume 144, Issue 25, Page 1977-1980, December 21, 2021. (Circulation)
• 08:00
  Incidence and Expected Probability of Liver Cirrhosis and Hepatocellular Carcinoma After Fontan Operation - Masaki Nii Ryo Inuzuka Kei Inai Eriko Shimada Tokuko Shinohara Tomomi Kogiso Hiroshi Ono Shinichi Ootsuki Yoshihiko Kurita Atsuhito Takeda Keiichi Hirono Kota Takei Satoshi Yasukochi Tadahiro Yoshikawa Yoshiyuki Furutani Tomohiro Shinozaki Yutaka Matsuyama Hideaki Senzaki Katsutoshi Tokushige Toshio Nakanishi Department of Pediatric Cardiology, Shizuoka Children’s Hospital, Japan (M.N.). Departments of Pediatrics (R.I.), University of Tokyo, Japan. Biostatistics, School of Public Health (Y.M.), University of Tokyo, Japan. Departments of Pediatric Cardiology and Adult Congenital Cardiology (...) Circulation
  Circulation, Volume 144, Issue 25, Page 2043-2045, December 21, 2021. (Circulation)
• 08:00
  From the Literature - Tracy Hampton Circulation
  Circulation, Volume 144, Issue 25, Page 2038-2039, December 21, 2021. (Circulation)
• 08:00
  Centering Equity in Cardiovascular Care - Bridget M. Kuehn Circulation
  Circulation, Volume 144, Issue 25, Page 2035-2037, December 21, 2021. (Circulation)
• 08:00
  Fish Oil Supplements May Increase the Risk for Atrial Fibrillation: What Does This Mean? - Michelle Samuel Stanley Nattel Research Center and Department of Medicine, Montreal Heart Institute, Université de Montréal, Canada (M.S., S.N.). Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen (S.N.). Institut Hospitalo-Universitaire - l’Institut de Rythmologie et Modélisation Cardiaque (IHU LIRYC) and Fondation Bordeaux Université, France (S.N.). Circulation
  Circulation, Volume 144, Issue 25, Page 1991-1994, December 21, 2021. (Circulation)

17 December

Circulation http://ahajournals.org/

• 11:00
  PRDM16 Is a Compact Myocardium-Enriched Transcription Factor Required to Maintain Compact Myocardial Cardiomyocyte Identity in Left Ventricle - Tongbin Wu Zhengyu Liang Zengming Zhang Canzhao Liu Lunfeng Zhang Yusu Gu Kirk L. Peterson Sylvia M. Evans Xiang-Dong Fu Ju Chen Department of Medicine (T.W., Z.Z., C.L., Y.G., K.L.P., S.M.E., J.C.), University of California San Diego, La Jolla. Department of Cellular and Molecular Medicine (Z.L., X.-D.F.), University of California San Diego, La Jolla. Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences (L.Z., S.M.E.), University of California San Diego, La Jolla. Institute of Genomic Medicine (X.-D.F.), University of California San Diego, La (...) Circulation
  Circulation, Volume 145, Issue 8, Page 586-602, February 22, 2022. Background:Left ventricular noncompaction cardiomyopathy (LVNC) was discovered half a century ago as a cardiomyopathy with excessive trabeculation and a thin ventricular wall. In the decades since, numerous studies have (...) (Circulation)

16 December

Circulation http://ahajournals.org/

• 02:13
  DREAM-ICD-II Study - Christian Steinberg Nicolas Dognin Amit Sodhi Catherine Champagne John A. Staples Jean Champagne Zachary W. Laksman Jean-François Sarrazin Matthew T. Bennett Benoit Plourde Marc W. Deyell Jason G. Andrade Karine Roy John A. Yeung-Lai-Wah Nathaniel M. Hawkins Blandine Mondésert Louis Blier Isabelle Nault Gilles O’Hara Andrew D. Krahn François Philippon Santabhanu Chakrabarti Institut universitaire de cardiologie et pneumologie de Québec, Quebec, Canada (C.S., N.D., C.C., J.C., J.-F.S., B.P., K.R., L.B., I.N., G.O., F.P.). Centre for Cardiovascular Innovation, Division of Cardiology (A.S., Z.L., (...) Circulation
  Circulation, Volume 145, Issue 10, Page 742-753, March 8, 2022. Background:Regulatory authorities of most industrialized countries recommend 6 months of private driving restriction after implantation of a secondary prevention implantable cardioverter-defibrillator (ICD). These driving (...) (Circulation)
• 04:53
  AtheroSpectrum Reveals Novel Macrophage Foam Cell Gene Signatures Associated With Atherosclerotic Cardiovascular Disease Risk - Chuan Li Lili Qu Alyssa J. Matz Patrick A. Murphy Yongmei Liu Ani W. Manichaikul Derek Aguiar Stephen S. Rich David M. Herrington David Vu W. Craig Johnson Jerome I. Rotter Wendy S. Post Anthony T. Vella Annabelle Rodriguez-Oquendo Beiyan Zhou Department of Immunology (C.L., L.Q., A.J.M., A.T.V., B.Z.), University of Connecticut, Farmington. Center for Vascular Biology (P.A.M., A.R.-O.), University of Connecticut, Farmington. School of Medicine, and Institute for Systems Genomics (A.T.V., B.Z.), University of Connecticut, Farmington. Department of Medicine, Divisions of Cardiology and (...) Circulation
  Circulation, Volume 145, Issue 3, Page 206-218, January 18, 2022. Background:Whereas several interventions can effectively lower lipid levels in people at risk for atherosclerotic cardiovascular disease (ASCVD), cardiovascular event risks remain, suggesting an unmet medical need to identify (...) (Circulation)

14 December

Circulation http://ahajournals.org/

• 11:00
  Effect of the Glucagon-Like Peptide-1 Receptor Agonists Semaglutide and Liraglutide on Kidney Outcomes in Patients With Type 2 Diabetes: Pooled Analysis of SUSTAIN 6 and LEADER - Ahmed M. Shaman Stephen C. Bain George L. Bakris John B. Buse Thomas Idorn Kenneth W. Mahaffey Johannes F.E. Mann Michael A. Nauck Søren Rasmussen Peter Rossing Benjamin Wolthers Bernard Zinman Vlado Perkovic Sydney School of Public Health, University of Sydney, Australia (A.M.S.). The George Institute for Global Health, The University of New South Wales, Sydney, Australia (A.M.S., V.P.). College of Pharmacy, King Saud University, Riyadh, Saudi Arabia (A.M.S.). Institute of Life Science, Swansea University Medical School, Singleton Hospital, Swansea, United Kingdom (S.C.B.). University of (...) Circulation
  Circulation, Volume 145, Issue 8, Page 575-585, February 22, 2022. Background:We assessed the effect of once-weekly semaglutide and once-daily liraglutide on kidney outcomes in type 2 diabetes.Methods:Pooled (n=12 637) and by-trial data from SUSTAIN 6 (Trial to Evaluate Cardiovascular and Other (...) (Circulation)
• 11:53
  Reading Frame Repair of TTN Truncation Variants Restores Titin Quantity and Functions - Robert Romano Shahnaz Ghahremani Talia Zimmerman Nicholas Legere Ketan Thakar Feria A. Ladha Anthony M. Pettinato J. Travis Hinson University of Connecticut Health Center, Farmington (R.R., F.A.L., A.M.P., J.T.H.). The Jackson Laboratory for Genomic Medicine, Farmington, CT (S.G., T.Z., N.L., K.T., J.T.H.). Circulation
  Circulation, Volume 145, Issue 3, Page 194-205, January 18, 2022. Background:Titin truncation variants (TTNtvs) are the most common inheritable risk factor for dilated cardiomyopathy (DCM), a disease with high morbidity and mortality. The pathogenicity of TTNtvs has been associated with (...) (Circulation)
• 11:43
  Mechanisms of Sinoatrial Node Dysfunction in Heart Failure With Preserved Ejection Fraction - Thassio Mesquita Rui Zhang Jae Hyung Cho Rui Zhang Yen-Nien Lin Lizbeth Sanchez Joshua I. Goldhaber Joseph K. Yu Jialiu A. Liang Weixin Liu Natalia A. Trayanova Eugenio Cingolani Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (T.M., R.Z., J.H.C., R.Z., Y-N.L., L.S., J.I.G., W.L., E.C.). Department of Biomedical Engineering (J.K.Y., J.A.L., N.A.T.), Johns Hopkins University, Baltimore, MD. Alliance for Cardiovascular and Diagnostic and Treatment Innovation (N.A.T.), Johns Hopkins University, Baltimore, (...) Circulation
  Circulation, Volume 145, Issue 1, Page 45-60, January 4, 2022. Background:The ability to increase heart rate during exercise and other stressors is a key homeostatic feature of the sinoatrial node (SAN). When the physiological heart rate response is blunted, chronotropic incompetence limits (...) (Circulation)

13 December

Circulation http://ahajournals.org/

• 08:00
  Response by Trifan et al to Letter Regarding Article, “Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials” - Gabriela Trifan Philip B. Gorelick Fernando D. Testai University of Illinois Chicago (G.T., P.B.G., F.T.D.). Northwestern University, Chicago, IL (P.B.G.). Circulation
  Circulation, Volume 144, Issue 24, Page e493-e494, December 14, 2021. (Circulation)
• 08:00
  Exercise-Induced Cardiac Troponin Elevations: From Underlying Mechanisms to Clinical Relevance - Vincent L. Aengevaeren Aaron L. Baggish Eugene H. Chung Keith George Øyunn Kleiven Alma M.A. Mingels Stein Ørn Rob E. Shave Paul D. Thompson Thijs M.H. Eijsvogels Radboud Institute for Health Sciences, Departments of Physiology (V.L.A., T.M.H.E.), Radboud University Medical Center, Nijmegen, The Netherlands. Cardiology (V.L.A.), Radboud University Medical Center, Nijmegen, The Netherlands. Cardiovascular Performance Program, Massachusetts General Hospital, Boston (A.L.B.). Michigan Medicine, University of Michigan, Ann Arbor (E.H.C.). Research Institute for Sport and Exercise Sciences, (...) Circulation
  Circulation, Volume 144, Issue 24, Page 1955-1972, December 14, 2021. Serological assessment of cardiac troponins (cTn) is the gold standard to assess myocardial injury in clinical practice. A greater magnitude of acutely or chronically elevated cTn concentrations is associated with lower (...) (Circulation)
• 08:00
  Letter by Zheng et al Regarding Article, “Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials” - Feng Zheng Niklas von Spreckelsen Weipeng Hu Department of Neurosurgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China (F.Z., W.H.). Department of Neurosurgery, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Germany (N.v.S.). Circulation
  Circulation, Volume 144, Issue 24, Page e491-e492, December 14, 2021. (Circulation)
• 08:00
  Nano-miR-133a Replacement Therapy Blunts Pressure Overload–Induced Heart Failure - Jessica Modica Vittoria Di Mauro Maria Barandalla-Sobrados Samuel Elias Pineda Chavez Pierluigi Carullo Simona Nemska Achille Anselmo Gianluigi Condorelli Michele Iafisco Michele Miragoli Daniele Catalucci National Research Council–Institute of Genetics and Biomedical Research, Milan Unit, Italy (J.M., V.D.M., M.B.-S., P.C., G.C., M.M., D.C.). IRCCS Humanitas Research Hospital, Rozzano (Milan), Italy (V.D.M., M.B.-S., S.E.P.C., P.C., S.N., A.A., M.M., D.C.). Department of Medicine and Surgery, University of Parma, Italy (S.E.P.C., M.M.). Humanitas University, Pieve Emanuele (Milan), Italy (...) Circulation
  Circulation, Volume 144, Issue 24, Page 1973-1976, December 14, 2021. (Circulation)
• 08:00
  Correction to: Heating Tobacco Sticks Instead of Combusting Conventional Cigarettes and Future Heart Attacks: Still Smoke, and Risk Circulation
  Circulation, Volume 144, Issue 24, Page e550-e550, December 14, 2021. (Circulation)
• 08:00
  Accelerated Epigenetic Aging and Incident Atrial Fibrillation: New Outlook on an Immutable Risk Factor? - Cavin K. Ward-Caviness Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC Circulation
  Circulation, Volume 144, Issue 24, Page 1912-1914, December 14, 2021. (Circulation)

10 December

Circulation http://ahajournals.org/

• 04:12
  Periodic Repolarization Dynamics Identifies ICD Responders in Nonischemic Cardiomyopathy: A DANISH Substudy - Rune Boas Nikolay Sappler Lukas von Stülpnagel Mathias Klemm Ulrik Dixen Jens Jakob Thune Steen Pehrson Lars Køber Jens C. Nielsen Lars Videbæk Jens Haarbo Eva Korup Niels Eske Bruun Axel Brandes Hans Eiskjær Anna M. Thøgersen Berit T. Philbert Jesper Hastrup Svendsen Jacob Tfelt-Hansen Axel Bauer Konstantinos D. Rizas Department of Cardiology, Amager Hvidovre University Hospital, University of Copenhagen, Denmark (R.B., U.D.). Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (R.B., U.D., J.J.T., S.P., L.K., N.E.B., J.H.S.). Department (...) Circulation
  Circulation, Volume 145, Issue 10, Page 754-764, March 8, 2022. Background:Identification of patients with nonischemic cardiomyopathy who may benefit from prophylactic implantation of a cardioverter-defibrillator. We hypothesized that periodic repolarization dynamics (PRD), a marker of (...) (Circulation)

9 December

Circulation http://ahajournals.org/

• 07:40
  Long-Term Follow-Up of DANISH (The Danish Study to Assess the Efficacy of ICDs in Patients With Nonischemic Systolic Heart Failure on Mortality) - Adelina Yafasova Jawad H. Butt Marie B. Elming Jens C. Nielsen Jens Haarbo Lars Videbæk Line L. Olesen Flemming H. Steffensen Niels E. Bruun Hans Eiskjær Axel Brandes Anna M. Thøgersen Kenneth Egstrup Finn Gustafsson Christian Hassager Jesper H. Svendsen Dan E. Høfsten Christian Torp-Pedersen Steen Pehrson Jens J. Thune Lars Køber Department of Cardiology, Copenhagen University Hospital–Rigshospitalet, Denmark (A.Y., J.H.B., M.B.E., F.G., C.H., J.H.S., D.E.H., S.P., L.K.). Department of Internal Medicine (M.B.E.), Zealand University Hospital, Roskilde, Denmark. Department of Cardiology (L.L.O., (...) Circulation
  Circulation, Volume 145, Issue 6, Page 427-436, February 8, 2022. Background:DANISH (The Danish Study to Assess the Efficacy of Implantable Cardioverter Defibrillators [ICDs] in Patients With Nonischemic Systolic Heart Failure on Mortality) found that primary-prevention ICD implantation was not (...) (Circulation)
• 08:00
  The Long-Awaited Revascularization Guidelines Are Out: What’s In Them? - Kendra J. Grubb Ajay J. Kirtane Division of Cardiothoracic Surgery, Emory University, Atlanta, GA (K.J.G.). Division of Cardiology, New York-Presbyterian Hospital/Columbia University Irving Medical Center (A.J.K.). Cardiovascular Research Foundation, NY (A.J.K.). Circulation
  Circulation, Volume 145, Issue 3, Page 155-157, January 18, 2022. (Circulation)
• 08:00
  2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines - Jennifer S. Lawton Jacqueline E. Tamis-Holland Sripal Bangalore Eric R. Bates Theresa M. Beckie James M. Bischoff John A. Bittl Mauricio G. Cohen J. Michael DiMaio Creighton W. Don Stephen E. Fremes Mario F. Gaudino Zachary D. Goldberger Michael C. Grant Jang B. Jaswal Paul A. Kurlansky Roxana Mehran Thomas S. Metkus Lorraine C. Nnacheta Sunil V. Rao Frank W. Sellke Garima Sharma Celina M. Yong Brittany A. Zwischenberger *Writing committee members are required to recuse themselves from voting on sections to which their specific relationships with industry may apply; see Appendix 1 for (...) Circulation
  Circulation, Volume 145, Issue 3, Page e18-e114, January 18, 2022. (Circulation)
• 08:00
  2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines - Jennifer S. Lawton Jacqueline E. Tamis-Holland Sripal Bangalore Eric R. Bates Theresa M. Beckie James M. Bischoff John A. Bittl Mauricio G. Cohen J. Michael DiMaio Creighton W. Don Stephen E. Fremes Mario F. Gaudino Zachary D. Goldberger Michael C. Grant Jang B. Jaswal Paul A. Kurlansky Roxana Mehran Thomas S. Metkus Lorraine C. Nnacheta Sunil V. Rao Frank W. Sellke Garima Sharma Celina M. Yong Brittany A. Zwischenberger *Writing committee members are required to recuse themselves from voting on sections to which their specific relationships with industry may apply; see Appendix 1 of the (...) Circulation
  Circulation, Volume 145, Issue 3, Page e4-e17, January 18, 2022. Aim:The executive summary of the American College of Cardiology/American Heart Association/Society for Cardiovascular Angiography and Interventions coronary artery revascularization guideline provides the top 10 items readers (...) (Circulation)

8 December

Circulation http://ahajournals.org/

• 12:30
  Determinants of Incident Atherosclerotic Cardiovascular Disease Events Among Those With Absent Coronary Artery Calcium: Multi-Ethnic Study of Atherosclerosis - Mahmoud Al Rifai Michael J. Blaha Vijay Nambi Steven J.C. Shea Erin D. Michos Roger S. Blumenthal Christie M. Ballantyne Moyses Szklo Philip Greenland Michael D. Miedema Khurram Nasir Jerome I. Rotter Xiuqing Guo Jie Yao Wendy S. Post Salim S. Virani Section of Cardiology, Baylor College of Medicine, Houston, TX (M.A.R., V.N., C.M.B., S.S.V.). The Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University, Baltimore, MD (M.J.B., E.D.M., R.S.B., W.S.P.). Section of Cardiology, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (V.N., S.S.V.). (...) Circulation
  Circulation, Volume 145, Issue 4, Page 259-267, January 25, 2022. Background:The 2018 American Heart Association/American College of Cardiology/Multisociety cholesterol guideline states that statin therapy may be withheld or delayed among intermediate-risk individuals in the absence of coronary (...) (Circulation)

7 December

Circulation http://ahajournals.org/

• 10:18
  An International Multicenter Cohort Study on ?-Blockers for the Treatment of Symptomatic Children With Catecholaminergic Polymorphic Ventricular Tachycardia - Puck J. Peltenburg Dania Kallas Johan M. Bos Krystien V.V. Lieve Sonia Franciosi Thomas M. Roston Isabelle Denjoy Katrina B. Sorensen Seiko Ohno Ferran Roses-Noguer Takeshi Aiba Alice Maltret Martin J. LaPage Joseph Atallah John R. Giudicessi Sally-Ann B. Clur Nico A. Blom Michael Tanck Fabrice Extramiana Koichi Kato Julien Barc Martin Borggrefe Elijah R. Behr Georgia Sarquella-Brugada Jacob Tfelt-Hansen Esther Zorio Heikki Swan Janneke A.E. Kammeraad Andrew D. Krahn Andrew Davis Frederic Sacher Peter J. Schwartz Jason D. Roberts Jonathan R. Skinner Maarten P. van den Berg Prince J. (...) Circulation
  Circulation, Volume 145, Issue 5, Page 333-344, February 1, 2022. Background:Symptomatic children with catecholaminergic polymorphic ventricular tachycardia (CPVT) are at risk for recurrent arrhythmic events. ?-Blockers decrease this risk, but studies comparing individual ?-blockers in sizeable (...) (Circulation)
• 10:58
  Identification of Drug Transporter Genomic Variants and Inhibitors That Protect Against Doxorubicin-Induced Cardiotoxicity - Tarek Magdy Mariam Jouni Hui-Hsuan Kuo Carly J. Weddle Davi Lyra-Leite Hananeh Fonoudi Marisol Romero-Tejeda Mennat Gharib Hoor Javed Giovanni Fajardo Colin J.D. Ross Bruce C. Carleton Daniel Bernstein Paul W. Burridge Department of Pharmacology, and the Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL (T.M., M.J., H-H.K., C.J.W., D.L-L., H.F., M.R-T., M.G., H.J., P.W.B.). Division of Cardiology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA (G.F., D.B.). British Columbia Children’s Hospital Research Institute (...) Circulation
  Circulation, Volume 145, Issue 4, Page 279-294, January 25, 2022. Background:Multiple pharmacogenomic studies have identified the synonymous genomic variant rs7853758 (G > A, L461L) and the intronic variant rs885004 inSLC28A3(solute carrier family 28 member 3) as statistically associated with a (...) (Circulation)

6 December

Circulation http://ahajournals.org/

• 11:00
  Clinically Suspected Myocarditis Temporally Related to COVID-19 Vaccination in Adolescents and Young Adults: Suspected Myocarditis After COVID-19 Vaccination - Dongngan T. Truong Audrey Dionne Juan Carlos Muniz Kimberly E. McHugh Michael A. Portman Linda M. Lambert Deepika Thacker Matthew D. Elias Jennifer S. Li Olga H. Toro-Salazar Brett R. Anderson Andrew M. Atz C. Monique Bohun M. Jay Campbell Maryanne Chrisant Laura D’Addese Kirsten B. Dummer Daniel Forsha Lowell H. Frank Olivia H. Frosch Sarah K. Gelehrter Therese M. Giglia Camden Hebson Supriya S. Jain Pace Johnston Anita Krishnan Kristin C. Lombardi Brian W. McCrindle Elizabeth C. Mitchell Koichi Miyata Trent Mizzi Robert M. Parker Jyoti K. Patel Christina Ronai Arash A. Sabati Jenna (...) Circulation
  Circulation, Volume 145, Issue 5, Page 345-356, February 1, 2022. Background:Understanding the clinical course and short-term outcomes of suspected myocarditis after the coronavirus disease 2019 (COVID-19) vaccination has important public health implications in the decision to vaccinate (...) (Circulation)
• 11:00
  Methodological Standards for the Design, Implementation, and Analysis of Randomized Trials in Cardiac Surgery: A Scientific Statement From the American Heart Association - Mario Gaudino Joanna Chikwe Emilia Bagiella Deepak L. Bhatt Torsten Doenst Stephen E. Fremes Jennifer Lawton Ruth M. Masterson Creber Robert M. Sade Brittany A. Zwischenberger Circulation
  Circulation, Volume 145, Issue 4, Page e129-e142, January 25, 2022. Cardiac surgery presents specific methodological challenges in the design, implementation, and analysis of randomized controlled trials. The purposes of this scientific statement are to review key standards in cardiac surgery (...) (Circulation)
• 11:00
  Rise in Blood Pressure Observed Among US Adults During the COVID-19 Pandemic - Luke J. Laffin Harvey W. Kaufman Zhen Chen Justin K. Niles Andre R. Arellano Lance A. Bare Stanley L. Hazen Heart Vascular and Thoracic Institute, Cleveland Clinic, OH (L.J.L., S.L.H.). Quest Diagnostics, Secaucus, NJ (H.W.K., Z.C., J.K.N., A.R.A., L.A.B.). Circulation
  Circulation, Volume 145, Issue 3, Page 235-237, January 18, 2022. (Circulation)
• 08:00
  Acute Inferior Wall Myocardial Infarction: What Is the Culprit Artery? - Qinghua Chang Zhaolong Xu Renguang Liu Cardiovascular Institute of the First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning Province, China. Circulation
  Circulation, Volume 144, Issue 23, Page 1893-1895, December 7, 2021. (Circulation)
• 08:00
  Letter by Chiang et al Regarding Article, “Late Outcomes of the RAPID-TnT Randomized Controlled Trial: 0/1-Hour High-Sensitivity Troponin T Protocol in Suspected ACS” - Cho-Han Chiang Cho-Hung Chiang Chien-Chang Lee School of Medicine, National Taiwan University College of Medicine, Taipei (Cho-Han Chiang). Division of General Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Foundation, New Taipei City, Taiwan (Cho-Hung Chiang). Health Data Science Research Group; Department of Emergency Medicine; The Centre for Intelligent Healthcare, National Taiwan University Hospital, Taipei, Taiwan (C.C.L.). Harvard Medical School, Boston, MA (Cho-Han (...) Circulation
  Circulation, Volume 144, Issue 23, Page e457-e458, December 7, 2021. (Circulation)
• 08:00
  Response by Lambrakis and Chew to Letter Regarding Article, “Late Outcomes of the RAPID-TnT Randomized Controlled Trial: 0/1-Hour High-Sensitivity Troponin T Protocol in Suspected ACS” - Kristina Lambrakis Derek P. Chew College of Medicine & Public Health, Flinders University of South Australia, Adelaide (K.L., D.P.C.). South Australian Department of Health, Adelaide (K.L., D.P.C.). Circulation
  Circulation, Volume 144, Issue 23, Page e459-e460, December 7, 2021. (Circulation)
• 08:00
  High Prevalence of Unrecognized Congenital Heart Disease in School-Age Children in Rural China: A Population-Based Echocardiographic Screening Study - Quming Zhao Hongyan Chen Guowen Zhang Weicheng Chen Bing Jia Fang Liu Xiaojing Ma Weili Yan Conway Niu Guoying Huang Pediatric Heart Center (Q.Z., W.C., B.J., F.L., X.M., G.H.), Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, China. Department of Clinical Epidemiology and Clinical Trial Unit (H.C., W.Y.), Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, China. Shanghai Key Laboratory of Birth Defects, China (Q.Z., W.C., B.J., F.L., X.M., G.H.). Pediatric Department, Luchun County People’s Hospital, Yunnan Province, (...) Circulation
  Circulation, Volume 144, Issue 23, Page 1896-1898, December 7, 2021. (Circulation)
• 08:00
  Correction to: Novel Criteria for the Observe-Zone of the ESC 0/1h-hs-cTnT Algorithm Circulation
  Circulation, Volume 144, Issue 23, Page e488-e488, December 7, 2021. (Circulation)
• 08:00
  Correction to: Reduced Mitochondrial Oxidactive Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity Circulation
  Circulation, Volume 144, Issue 23, Page e489-e489, December 7, 2021. (Circulation)
• 08:00
  Correction to: Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis Circulation
  Circulation, Volume 144, Issue 23, Page e490-e490, December 7, 2021. (Circulation)
• 08:00
  Persistent Heart Effects of COVID-19 Emphasize the Need for Prevention - Bridget M. Kuehn Circulation
  Circulation, Volume 144, Issue 23, Page 1891-1892, December 7, 2021. (Circulation)
• 08:00
  Navigating the Passage for Better Understanding and Prognosis for Acute Limb Ischemia After Lower-Extremity Revascularization - Mette Søgaard Nikolaj Eldrup Peter Brønnum Nielsen Department of Cardiology, Aalborg University Hospital, Denmark (M.S., P.B.N.). Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Denmark (M.S., P.B.N.). Department of Vascular Surgery, Rigshospitalet, Copenhagen University, Denmark (N.E.). Circulation
  Circulation, Volume 144, Issue 23, Page 1842-1844, December 7, 2021. (Circulation)

3 December

Circulation http://ahajournals.org/

• 08:53
  Diabetes Status Modifies the Association Between Different Measures of Obesity and Heart Failure Risk Among Older Adults: A Pooled Analysis of Community-Based NHLBI Cohorts - Kershaw V. Patel Matthew W. Segar Carl J. Lavie Nitin Kondamudi Ian J. Neeland Jaime P. Almandoz Corby K. Martin Salvatore Carbone Javed Butler Tiffany M. Powell-Wiley Ambarish Pandey Department of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, TX (K.V.P.). Department of Cardiology, Texas Heart Institute, Houston (M.W.S.). Department of Internal Medicine, Ochsner Clinical School–University of Queensland School of Medicine, New Orleans, LA (C.J.L.). Division of Cardiology (N.K., A.P.), Department of Internal Medicine, University of Texas Southwestern Medical Center, (...) Circulation
  Circulation, Volume 145, Issue 4, Page 268-278, January 25, 2022. Background:Obesity and diabetes are associated with a higher risk of heart failure (HF). The interrelationships between different measures of adiposity—overall obesity, central obesity, fat mass (FM)—and diabetes status for HF risk (...) (Circulation)

1 December

Circulation http://ahajournals.org/

• 11:00
  Supporting Physical Activity in Patients and Populations During Life Events and Transitions: A Scientific Statement From the American Heart Association - Abbi D. Lane-Cordova Gerald J. Jerome Amanda E. Paluch Eduardo Esteban Bustamante Michael J. LaMonte Russell R. Pate R. Glenn Weaver Kashica J. Webber-Ritchey Bethany Barone Gibbs Circulation
  Circulation, Volume 145, Issue 4, Page e117-e128, January 25, 2022. Achieving recommended levels of physical activity is important for optimal cardiovascular health and can help reduce cardiovascular disease risk. Emerging evidence suggests that physical activity fluctuates throughout the life (...) (Circulation)

30 November

Circulation http://ahajournals.org/

• 06:16
  Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency - Huijuan Dou Andriana Kotini Wenli Liu Trevor Fidler Kaori Endo-Umeda Xiaoli Sun Malgorzata Olszewska Tong Xiao Sandra Abramowicz Mustafa Yalcinkaya Brian Hardaway Sotirios Tsimikas Xuchu Que Alexander Bick Conor Emdin Pradeep Natarajan Eirini P. Papapetrou Joseph L. Witztum Nan Wang Alan R. Tall Molecular Medicine, Columbia University Medical Center, New York (H.D., W.L., T.F., K.E.-U., T.X., S.A., M.Y., B.H., N.W., A.R.T.). Department of Medicine, University of California, San Diego (X.S., S.T., X.Q., J.L.W.). Division of Biochemistry, Department of Biomedical Sciences, Nihon University (...) Circulation
  Circulation, Volume 144, Issue 24, Page 1940-1954, December 14, 2021. Background:LNK/SH2B3 inhibits Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling by hematopoietic cytokine receptors. Genome-wide association studies have shown association of a common single (...) (Circulation)

29 November

Circulation http://ahajournals.org/

• 08:00
  Wide and Narrow QRS Complex Tachycardia With Cycle Length Alternans: What Is the Mechanism? - Bryan Richard Sasmita Suxin Luo Bi Huang Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, China. Circulation
  Circulation, Volume 144, Issue 22, Page 1824-1826, November 30, 2021. (Circulation)
• 08:00
  NAD+ Metabolism in Cardiac Health, Aging, and Disease - Mahmoud Abdellatif Simon Sedej Guido Kroemer Department of Cardiology, Medical University of Graz, Austria (M.A., S.S.). Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France (M.A., G.K.). Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Institut national de la santé et de la recherche médicale (INSERM) U1138, Institut Universitaire de France (M.A., G.K.). BioTechMed Graz, Austria (S.S.). Institute of Physiology, Faculty of Medicine, University of Maribor, Slovenia (S.S.). Pôle de (...) Circulation
  Circulation, Volume 144, Issue 22, Page 1795-1817, November 30, 2021. Nicotinamide adenine dinucleotide (NAD+) is a central metabolite involved in energy and redox homeostasis as well as in DNA repair and protein deacetylation reactions. Pharmacological or genetic inhibition of NAD+-degrading (...) (Circulation)
• 08:00
  Sudden Death in Female Athletes: Insights From a Large Regional Registry in the United Kingdom - Gherardo Finocchiaro Joe Westaby Raghav Bhatia Aneil Malhotra Elijah R. Behr Michael Papadakis Sanjay Sharma Mary N. Sheppard Cardiology Clinical Academic Group, St George’s, University of London, United Kingdom (G.F., J.W., R.B., E.B., M.P., S.S., M.N.S.). Cardiothoracic Centre, Guy’s and St Thomas’ Hospital, London, United Kingdom (G.F.). King’s College London, United Kingdom (G.F.). Cardiovascular Research Centre, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom (G.F.). Division of Cardiovascular Science, University of Manchester, Manchester University NHS (...) Circulation
  Circulation, Volume 144, Issue 22, Page 1827-1829, November 30, 2021. (Circulation)
• 08:00
  Letter by Spiering et al Regarding Article, “Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis: A Double-Blind Randomized Controlled Trial” - Wilko Spiering Willem P. Mali Pim A. de Jong Departments of Vascular Medicine (W.S.), University Medical Center Utrecht, The Netherlands. Radiology (W.P.M., P.A.d.J.), University Medical Center Utrecht, The Netherlands. Circulation
  Circulation, Volume 144, Issue 22, Page e334-e334, November 30, 2021. (Circulation)
• 08:00
  Response by Bing et al to Letter Regarding Article, “Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis: A Double-Blind Randomized Controlled Trial” - Rong Bing David E. Newby Stuart H. Ralston Marc R. Dweck BHF Centre for Cardiovascular Science (R.B., D.E.N., M.R.D.), University of Edinburgh, UK. Institute of Genetics and Molecular Medicine (S.H.R.), University of Edinburgh, UK. Circulation
  Circulation, Volume 144, Issue 22, Page e335-e335, November 30, 2021. (Circulation)
• 08:00
  Correction to: 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines Circulation
  Circulation, Volume 144, Issue 22, Page e455-e455, November 30, 2021. (Circulation)
• 08:00
  Correction to: Chest Pain Redux: Updated and Patient Centered Circulation
  Circulation, Volume 144, Issue 22, Page e456-e456, November 30, 2021. (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 144, Issue 22, Page 1818-1823, November 30, 2021. (Circulation)
• 08:00
  Embolic Stroke of Undetermined Source: Can We Identify Subgroups With High Risk for Atrial Fibrillation Who May Benefit From Oral Anticoagulation? - Graeme J. Hankey Medical School, Faculty of Health and Medical Sciences, The University of Western Australia, Perth. Department of Neurology, Sir Charles Gairdner Hospital, Perth, Australia. Circulation
  Circulation, Volume 144, Issue 22, Page 1747-1749, November 30, 2021. (Circulation)

24 November

Circulation http://ahajournals.org/

• 11:01
  Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease - Daniel H. Katz Usman A. Tahir Alexander G. Bick Akhil Pampana Debby Ngo Mark D. Benson Zhi Yu Jeremy M. Robbins Zsu-Zsu Chen Daniel E. Cruz Shuliang Deng Laurie Farrell Sumita Sinha Alec A. Schmaier Dongxiao Shen Yan Gao Michael E. Hall Adolfo Correa Russell P. Tracy Peter Durda Kent D. Taylor Yongmei Liu W. Craig Johnson Xiuqing Guo Jie Yao Yii-Der Ida Chen Ani W. Manichaikul Deepti Jain Claude Bouchard Mark A. Sarzynski Stephen S. Rich Jerome I. Rotter Thomas J. Wang James G. Wilson Pradeep Natarajan Robert E. Gerszten Division of Cardiovascular Medicine, Beth Israel Deaconess Medical (...) Circulation
  Circulation, Volume 145, Issue 5, Page 357-370, February 1, 2022. Background:Plasma proteins are critical mediators of cardiovascular processes and are the targets of many drugs. Previous efforts to characterize the genetic architecture of the plasma proteome have been limited by a focus on (...) (Circulation)
• 11:01
  Influence of Monitoring Strategy on Assessment of Ablation Success and Postablation Atrial Fibrillation Burden Assessment: Implications for Practice and Clinical Trial Design - Martin Aguilar Laurent Macle Marc W. Deyell Robert Yao Nathaniel M. Hawkins Paul Khairy Jason G. Andrade Montreal Heart Institute, Department of Medicine, Université de Montréal, Montréal, Canada (M.A., L.M., P.K., J.G.A.). Department of Medicine, University of British Columbia, Vancouver, Canada (M.W.D., R.Y., N.H., J.G.A.). Center for Cardiovascular Innovation, Vancouver, Canada (M.W.D., N.H., J.G.A.). Circulation
  Circulation, Volume 145, Issue 1, Page 21-30, January 4, 2022. Background:Various noninvasive intermittent rhythm monitoring strategies have been used to assess arrhythmia recurrences in trials evaluating pharmacological and invasive therapeutic interventions for atrial fibrillation (AF). We (...) (Circulation)
• 11:00
  Anterior–Lateral Versus Anterior–Posterior Electrode Position for Cardioverting Atrial Fibrillation - Anders Sjørslev Schmidt Kasper Glerup Lauridsen Dorthe Svenstrup Møller Per Dahl Christensen Karen Kaae Dodt Hans Rickers Bo Løfgren Andi Eie Albertsen Department of Internal Medicine, Randers Regional Hospital, Denmark (A.S.S., K.G.L., H.R., B.L.). Research Center for Emergency Medicine, Aarhus University Hospital, Denmark (A.S.S., K.G.L., B.L.). Department of Cardiology, Viborg Regional Hospital, Denmark (D.S.M., P.D.C., A.E.A.). Department of Internal Medicine, Horsens Regional Hospital, Denmark (K.K.D.). Department of Clinical Medicine, Aarhus University (...) Circulation
  Circulation, Volume 144, Issue 25, Page 1995-2003, December 21, 2021. Background:Smaller randomized studies have reported conflicting results regarding the optimal electrode position for cardioverting atrial fibrillation. However, anterior–posterior electrode positioning is widely used as a (...) (Circulation)
• 04:19
  Expression of Concern: Abstract 10712: Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning Circulation
  Circulation, Ahead of Print. (Circulation)

22 November

Circulation http://ahajournals.org/

• 02:47
  Extracellular Matrix in Heart Failure: Role of ADAMTS5 in Proteoglycan Remodeling - Javier Barallobre-Barreiro Tamás Radovits Marika Fava Ursula Mayr Wen-Yu Lin Elizaveta Ermolaeva Diego Martínez-López Eric L. Lindberg Elisa Duregotti László Daróczi Maria Hasman Lukas E. Schmidt Bhawana Singh Ruifang Lu Ferheen Baig Aleksandra Malgorzata Siedlar Friederike Cuello Norman Catibog Konstantinos Theofilatos Ajay M. Shah Maria G. Crespo-Leiro Nieves Doménech Norbert Hübner Béla Merkely Manuel Mayr King’s BHF Centre of Research Excellence, London, UK (J.B.-B., M.F., U.M., W.-Y.L., E.E., E.D., M.H., L.E.S., B.S., R.L., F.B., A.M.S., N.C., K.T., A.M.S., M.M.). Heart and Vascular Center, (...) Circulation
  Circulation, Volume 144, Issue 25, Page 2021-2034, December 21, 2021. Background:Remodeling of the extracellular matrix (ECM) is a hallmark of heart failure (HF). Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a disintegrin and metalloproteinase with (...) (Circulation)
• 08:00
  A Foot Soldier in Cardiac Metabolism: A Conversation With Heinrich Taegtmeyer, MD, DPhil - Maryjane Farr Circulation
  Circulation, Volume 144, Issue 21, Page 1659-1663, November 23, 2021. (Circulation)
• 08:00
  Letter by Naeije Regarding Article, “Oxygen Pathway Limitations in Patients With Chronic Thromboembolic Pulmonary Hypertension” - Robert Naeije Free University of Brussels, Faculty of Medicine, Laboratory of Physiology, Belgium. Circulation
  Circulation, Volume 144, Issue 21, Page e328-e329, November 23, 2021. (Circulation)
• 08:00
  Response by Howden et al to Letter Regarding Article, “Oxygen Pathway Limitations in Patients With Chronic Thromboembolic Pulmonary Hypertension” - Erin J. Howden Sergio Ruiz-Carmona André La Gerche Marion Delcroix Guido Claessen Baker Heart and Diabetes Institute, Melbourne, Australia (E.J.H., S.R.-H., A.L.G.). KU Leuven, Belgium (M.D., G.C.). University Hospitals Leuven, Belgium (M.D., G.C.). Circulation
  Circulation, Volume 144, Issue 21, Page e330-e331, November 23, 2021. (Circulation)
• 08:00
  Correction to: National Trends and Disparities in Hospitalization for Acute Hypertension Among Medicare Beneficiaries (1999–2019) Circulation
  Circulation, Volume 144, Issue 21, Page e333-e333, November 23, 2021. (Circulation)
• 08:00
  Retraction of: Abstract 03: High-Dose Intranasal Insulin During CPR Improves Neurological Outcomes in a Rat Model of Cardiac Arrest Circulation
  Circulation, Volume 144, Issue 21, Page e332-e332, November 23, 2021. (Circulation)

19 November

Circulation http://ahajournals.org/

• 08:49
  Impact of Sacubitril/Valsartan Versus Ramipril on Total Heart Failure Events in the PARADISE-MI Trial - Marc A. Pfeffer Brian Claggett Eldrin F. Lewis Christopher B. Granger Lars Køber Aldo P. Maggioni Douglas L. Mann John J.V. McMurray Jean-Lucien Rouleau Scott D. Solomon Philippe Gabriel Steg Otavio Berwanger Maja Cikes Carmine G. De Pasquale Alberto Fernandez Gerasimos Filippatos Karola Jering Ulf Landmesser Venugopal Menon Béla Merkely Mark C. Petrie Ivo Petrov Morten Schou Michele Senni David Sim Peter van der Meer Martin Lefkowitz Yinong Zhou Yi Wang Eugene Braunwald Cardiovascular Division, Brigham and Women’s Hospital, and Harvard Medical School Boston, MA (M.A.P., B.C., S.D.S., K.J.). (...) Circulation
  Circulation, Volume 145, Issue 1, Page 87-89, January 4, 2022. (Circulation)
• 07:46
  Seamless Genetic Recording of Transiently Activated Mesenchymal Gene Expression in Endothelial Cells During Cardiac Fibrosis - Shaohua Zhang Yan Li Xiuzhen Huang Kuo Liu Qing-Dong Wang Alex F. Chen Kun Sun Kathy O. Lui Bin Zhou State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (S.Z., Y.L., X.H., K.L., B.Z.), University of Chinese Academy of Sciences. School of Life Science, Hangzhou Institute for Advanced Study (K.L., B.Z.), University of Chinese Academy of Sciences. School of Life Science and Technology, Shanghai Tech University, China (K.L., B.Z.). Bioscience Cardiovascular, Research and Early (...) Circulation
  Circulation, Volume 144, Issue 25, Page 2004-2020, December 21, 2021. Background:Cardiac fibrosis is a lethal outcome of excessive formation of myofibroblasts that are scar-forming cells accumulated after heart injury. It has been reported that cardiac endothelial cells (ECs) contribute to a (...) (Circulation)

17 November

Circulation http://ahajournals.org/

• 10:07
  Retention of the NLRP3 Inflammasome–Primed Neutrophils in the Bone Marrow Is Essential for Myocardial Infarction–Induced Granulopoiesis - Gopalkrishna Sreejit Sunil K. Nooti Robert M. Jaggers Baskaran Athmanathan Ki Ho Park Annas Al-Sharea Jillian Johnson Albert Dahdah Man K.S. Lee Jianjie Ma Andrew J. Murphy Prabhakara R. Nagareddy Department of Surgery, The Ohio State University Wexner Medical Center, Columbus (G.S., R.M.J., B.A., K.H.P., J.J., A.D., J.M., P.R.N.). Department of Pathology, University of Alabama at Birmingham (G.S., S.K.N., B.A., P.R.N.). Division of Immunometabolism, Baker Heart and Diabetes Institute, Melbourne, Australia (A.A., M.K.S.L., A.J.M.). Department of Immunology, Monash University, Melbourne, (...) Circulation
  Circulation, Volume 145, Issue 1, Page 31-44, January 4, 2022. Background:Acute myocardial infarction (MI) results in overzealous production and infiltration of neutrophils to the ischemic heart. This is mediated in part by granulopoiesis induced by the S100A8/A9-NLRP3-IL-1? signaling axis in (...) (Circulation)

15 November

Circulation http://ahajournals.org/

• 03:39
  Empagliflozin, Health Status, and Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The EMPEROR-Preserved Trial - Javed Butler Gerasimos Filippatos Tariq Jamal Siddiqi Martina Brueckmann Michael Böhm Vijay K. Chopra João Pedro Ferreira James L. Januzzi Sanjay Kaul Ileana L. Piña Piotr Ponikowski Sanjiv J. Shah Michele Senni Ola Vedin Subodh Verma Barbara Peil Stuart J. Pocock Faiez Zannad Milton Packer Stefan D. Anker Department of Medicine, University of Mississippi School of Medicine, Jackson (J.B., T.J.S.). National and Kapodistrian University of Athens School of Medicine, Athens University Hospital Attikon, Greece (G.F.). Boehringer Ingelheim International GmbH, Ingelheim, Germany (M. Brueckmann). (...) Circulation
  Circulation, Volume 145, Issue 3, Page 184-193, January 18, 2022. Background:Patients with heart failure with preserved ejection fraction have significant impairment in health-related quality of life. In the EMPEROR-Preserved trial (Empagliflozin Outcome Trial in Patients With Chronic Heart (...) (Circulation)

14 November

Circulation http://ahajournals.org/

• 02:12
  Efpeglenatide and Clinical Outcomes With and Without Concomitant Sodium-Glucose Cotransporter-2 Inhibition Use in Type 2 Diabetes: Exploratory Analysis of the AMPLITUDE-O Trial - Carolyn S.P. Lam Chinthanie Ramasundarahettige Kelley R.H. Branch Naveed Sattar Julio Rosenstock Richard Pratley Stefano Del Prato Renato D. Lopes Elisabeth Niemoeller Nardev S. Khurmi Seungjae Baek Hertzel C. Gerstein National Heart Centre Singapore and Duke–National University of Singapore, Singapore (C.S.P.L.). Division of Cardiology, University of Washington, Seattle (K.R.H.B.). Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK (N.S.). Dallas Diabetes Research Center at Medical City, TX (J.R.). AdventHealth Translational Research Institute, Orlando, FL (R.P.). (...) Circulation
  Circulation, Volume 145, Issue 8, Page 565-574, February 22, 2022. Background:Both sodium-glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists reduce cardiovascular events among patients with type 2 diabetes. However, no cardiovascular outcome trial has (...) (Circulation)
• 11:27
  Efficacy and Safety of Appropriate Shocks and Antitachycardia Pacing in Transvenous and Subcutaneous Implantable Defibrillators: Analysis of All Appropriate Therapy in the PRAETORIAN Trial - Reinoud E. Knops Willeke van der Stuijt Peter Paul H.M. Delnoy Lucas V.A. Boersma Juergen Kuschyk Mikhael F. El-Chami Hendrik Bonnemeier Elijah R. Behr Tom F. Brouwer Stefan Kääb Suneet Mittal Anne-Floor B.E. Quast Lonneke Smeding Jan G.P. Tijssen Nick R. Bijsterveld Sergio Richter Marc A. Brouwer Joris R. de Groot Kirsten M. Kooiman Pier D. Lambiase Petr Neuzil Kevin Vernooy Marco Alings Timothy R. Betts Frank A.L.E. Bracke Martin C. Burke Jonas S.S.G. de Jong David J. Wright Ward P.J. Jansen Zachary I. Whinnet Peter Nordbeck Michael Knaut Berit T. Philbert Jurren M. van Opstal Alexandru (...) Circulation
  Circulation, Volume 145, Issue 5, Page 321-329, February 1, 2022. Background:The PRAETORIAN trial (A Prospective, Randomized Comparison of Subcutaneous and Transvenous Implantable Cardioverter Defibrillator Therapy) showed noninferiority of subcutaneous implantable cardioverter defibrillator (...) (Circulation)

13 November

Circulation http://ahajournals.org/

• 03:30
  Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis: The AVATAR Trial - Marko Banovic Svetozar Putnik Martin Penicka Gheorghe Doros Marek A. Deja Radka Kockova Martin Kotrc Sigita Glaveckaite Hrvoje Gasparovic Nikola Pavlovic Lazar Velicki Stefano Salizzoni Wojtek Wojakowski Guy Van Camp Serge D. Nikolic Bernard Iung Jozef Bartunek Belgrade Medical School, University of Belgrade, Serbia (M.B., S.P.). Cardiology Department (M.B.), University Clinical Center of Serbia, Belgrade. Cardiac-Surgery Department (S.P.), University Clinical Center of Serbia, Belgrade. Cardiovascular Center, OLV Hospital, Aalst, Belgium (M.P., G.V.C., J.B.). Boston University School of (...) Circulation
  Circulation, Volume 145, Issue 9, Page 648-658, March 1, 2022. Background:Surgical aortic valve replacement (SAVR) represents a class I indication in symptomatic patients with severe aortic stenosis (AS). However, indications for early SAVR in asymptomatic patients with severe AS and normal (...) (Circulation)
• 05:20
  Finerenone Reduces Risk of Incident Heart Failure in Patients With Chronic Kidney Disease and Type 2 Diabetes: Analyses From the FIGARO-DKD Trial - Gerasimos Filippatos Stefan D. Anker Rajiv Agarwal Luis M. Ruilope Peter Rossing George L. Bakris Christoph Tasto Amer Joseph Peter Kolkhof Andrea Lage Bertram Pitt National and Kapodistrian University of Athens, School of Medicine, Department of Cardiology, Attikon University Hospital, Greece (G.F.). Department of Cardiology (Charité Campus Virchow-Klinikum) and Berlin Institute of Health Center for Regenerative Therapies, German Centre for Cardiovascular Research Partner Site Berlin, Charité Universitätsmedizin (S.D.A.). Richard L. Roudebush VA Medical Center and Indiana University, (...) Circulation
  Circulation, Volume 145, Issue 6, Page 437-447, February 8, 2022. Background:Chronic kidney disease and type 2 diabetes are independently associated with heart failure (HF), a leading cause of morbidity and mortality. In the FIDELIO-DKD (Finerenone in Reducing Kidney Failure and Disease (...) (Circulation)

12 November

Circulation http://ahajournals.org/

• 08:09
  Inequalities in Income and Education Are Associated With Survival Differences After Out-of-Hospital Cardiac Arrest: Nationwide Observational Study - Martin Jonsson Juho Härkönen Petter Ljungman Per Nordberg Mattias Ringh Geir Hirlekar Araz Rawshani Johan Herlitz Rickard Ljung Jacob Hollenberg Center for Resuscitation Science, Department of Clinical Science and Education, Södersjukhuset (M.J., P.N., M.R., J. Hollenberg), Karolinska Institutet, Stockholm, Sweden. Institute of Environmental Medicine (P.L., R.L.), Karolinska Institutet, Stockholm, Sweden. Department of Political and Social Sciences, European University Institute, Florence, Italy (J. Härkönen). Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden (...) Circulation
  Circulation, Volume 144, Issue 24, Page 1915-1925, December 14, 2021. Background:Despite the acknowledged importance of socioeconomic factors as regards cardiovascular disease onset and survival, the relationship between individual-level socioeconomic factors and survival after out-of-hospital (...) (Circulation)

11 November

Circulation http://ahajournals.org/

• 11:00
  2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Neonatal Life Support; Education, Implementation, and Teams; First Aid Task Forces; and the COVID-19 Working Group - Myra H. Wyckoff Eunice M. Singletary Jasmeet Soar Theresa M. Olasveengen Robert Greif Helen G. Liley David Zideman Farhan Bhanji Lars W. Andersen Suzanne R. Avis Khalid Aziz Jason C. Bendall David C. Berry Vere Borra Bernd W. Böttiger Richard Bradley Janet E. Bray Jan Breckwoldt Jestin N. Carlson Pascal Cassan Maaret Castrén Wei-Tien Chang Nathan P. Charlton Adam Cheng Sung Phil Chung Julie Considine Daniela T. Costa-Nobre Keith Couper Katie N. Dainty Peter G. Davis Maria Fernanda de Almeida Allan R. de Caen Edison F. de Paiva Charles D. Deakin Therese Djärv Matthew J. Douma Ian R. Drennan (...) Circulation
  Circulation, Volume 145, Issue 9, Page e645-e721, March 1, 2022. The International Liaison Committee on Resuscitation initiated a continuous review of new, peer-reviewed published cardiopulmonary resuscitation science. This is the fifth annual summary of the International Liaison Committee on (...) (Circulation)
• 09:07
  CARDIOKIN1: Computational Assessment of Myocardial Metabolic Capability in Healthy Controls and Patients With Valve Diseases - Nikolaus Berndt Johannes Eckstein Iwona Wallach Sarah Nordmeyer Marcus Kelm Marieluise Kirchner Leonid Goubergrits Marie Schafstedde Anja Hennemuth Milena Kraus Tilman Grune Philipp Mertins Titus Kuehne Hermann-Georg Holzhütter Institute of Computer-Assisted Cardiovascular Medicine (N.B., J.E., I.W., S.N., M. Kelm, L.G., M.S., A.H., T.K.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, and Humboldt-Universität zu Berlin, Germany. Institute of Biochemistry (J.E., I.W., H.-G.H.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, (...) Circulation
  Circulation, Volume 144, Issue 24, Page 1926-1939, December 14, 2021. Background:Many heart diseases can result in reduced pumping capacity of the heart muscle. A mismatch between ATP demand and ATP production of cardiomyocytes is one of the possible causes. Assessment of the relation between (...) (Circulation)

10 November

Circulation http://ahajournals.org/

• 11:00
  Future Perspectives of Cardiovascular Biomarker Utilization in Cancer Survivors: A Scientific Statement From the American Heart Association - Vlad G. Zaha Salim S. Hayek Kevin M. Alexander Theresa M. Beckie W. Gregory Hundley Lavanya Kondapalli Bonnie Ky Kasey J. Leger Wouter C. Meijers Javid J. Moslehi Svati H. Shah Circulation
  Circulation, Volume 144, Issue 25, Page e551-e563, December 21, 2021. Improving cancer survival represents the most significant effect of precision medicine and personalized molecular and immunologic therapeutics. Cardiovascular health becomes henceforth a key determinant for the direction of (...) (Circulation)

8 November

Circulation http://ahajournals.org/

• 10:01
  Blood Pressure, Hypertension, and the Risk of Aortic Dissection Incidence and Mortality: Results From the J-SCH Study, the UK Biobank Study, and a Meta-Analysis of Cohort Studies - Makoto Hibino Yoichiro Otaki Elsa Kobeissi Han Pan Hiromi Hibino Henock Taddese Azeem Majeed Subodh Verma Tsuneo Konta Kunihiro Yamagata Shouichi Fujimoto Kazuhiko Tsuruya Ichiei Narita Masato Kasahara Yugo Shibagaki Kunitoshi Iseki Toshiki Moriyama Masahide Kondo Koichi Asahi Tsuyoshi Watanabe Tetsu Watanabe Masafumi Watanabe Dagfinn Aune Division of Cardiac Surgery, St. Michael’s Hospital (M.H., S.V.), University of Toronto, ON, Canada. Department of Surgery (M.H., S.V.), University of Toronto, ON, Canada. Department of Epidemiology and Biostatistics, School of Public Health, Imperial (...) Circulation
  Circulation, Volume 145, Issue 9, Page 633-644, March 1, 2022. Background:Hypertension or elevated blood pressure (BP) is an important risk factor for aortic dissection (AD); however, few prospective studies on this topic have been published. We investigated the association between (...) (Circulation)
• 10:02
  Serial Assessment of High-Sensitivity Cardiac Troponin and the Effect of Dapagliflozin in Patients With Heart Failure With Reduced Ejection Fraction: An Analysis of the DAPA-HF Trial - David D. Berg Kieran F. Docherty Naveed Sattar Petr Jarolim Paul Welsh Pardeep S. Jhund Inder S. Anand Vijay Chopra Rudolf A. de Boer Mikhail N. Kosiborod Jose C. Nicolau Eileen O’Meara Morten Schou Ann Hammarstedt Anna-Maria Langkilde Daniel Lindholm Mikaela Sjöstrand John J.V. McMurray Marc S. Sabatine David A. Morrow TIMI Study Group, Division of Cardiovascular Medicine (D.D.B., M.S.S., D.A.M.), Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. Department of Pathology (P.J.), Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. British Heart Foundation Glasgow (...) Circulation
  Circulation, Volume 145, Issue 3, Page 158-169, January 18, 2022. Background:Circulating high-sensitivity cardiac troponin T (hsTnT) predominantly reflects myocardial injury, and higher levels are associated with a higher risk of worsening heart failure and death in patients with heart failure (...) (Circulation)
• 11:00
  Deep Learning of the Retina Enables Phenome- and Genome-Wide Analyses of the Microvasculature - Seyedeh Maryam Zekavat Vineet K. Raghu Mark Trinder Yixuan Ye Satoshi Koyama Michael C. Honigberg Zhi Yu Akhil Pampana Sarah Urbut Sara Haidermota Declan P. O’Regan Hongyu Zhao Patrick T. Ellinor Ayellet V. Segrè Tobias Elze Janey L. Wiggs James Martone Ron A. Adelman Nazlee Zebardast Lucian Del Priore Jay C. Wang Pradeep Natarajan Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT (S.M.Z., J.M., R.A.A., L.D.P., J.C.W.). Computational Biology & Bioinformatics Program (S.M.Z., Y.Y., H.Z.), Yale University, New Haven, CT. School of Public Health (H.Z.), (...) Circulation
  Circulation, Volume 145, Issue 2, Page 134-150, January 11, 2022. Background:The microvasculature, the smallest blood vessels in the body, has key roles in maintenance of organ health and tumorigenesis. The retinal fundus is a window for human in vivo noninvasive assessment of the (...) (Circulation)
• 10:01
  Estimation of DAPT Study Treatment Effects in Contemporary Clinical Practice: Findings From the EXTEND-DAPT Study - Neel M. Butala Kamil F. Faridi Hector Tamez Jordan B. Strom Yang Song Changyu Shen Eric A. Secemsky Laura Mauri Dean J. Kereiakes Jeptha P. Curtis C. Michael Gibson Robert W. Yeh Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston MA (N.M,B., H.T., J.B.S., Y.S., C.S., E.A.S., C.M.G., R.W.Y.). Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (N.M.B.). Section of Cardiovascular Medicine, Department of Medicine, Yale School of (...) Circulation
  Circulation, Volume 145, Issue 2, Page 97-106, January 11, 2022. Background:Differences in patient characteristics, changes in treatment algorithms, and advances in medical technology could each influence the applicability of older randomized trial results to contemporary clinical practice. The (...) (Circulation)
• 10:00
  ECG-Based Deep Learning and Clinical Risk Factors to Predict Atrial Fibrillation - Shaan Khurshid Samuel Friedman Christopher Reeder Paolo Di Achille Nathaniel Diamant Pulkit Singh Lia X. Harrington Xin Wang Mostafa A. Al-Alusi Gopal Sarma Andrea S. Foulkes Patrick T. Ellinor Christopher D. Anderson Jennifer E. Ho Anthony A. Philippakis Puneet Batra Steven A. Lubitz Division of Cardiology (S.K., M.A.A., J.E.H.), Massachusetts General Hospital, Boston. Cardiovascular Research Center (S.K., L.X.H., X.W., M.A.A., P.T.E., J.E.H., S.A.L.), Massachusetts General Hospital, Boston. Biostatistics Center (A.S.F.), Massachusetts General Hospital, Boston. Cardiac Arrhythmia Service (...) Circulation
  Circulation, Volume 145, Issue 2, Page 122-133, January 11, 2022. Background:Artificial intelligence (AI)–enabled analysis of 12-lead ECGs may facilitate efficient estimation of incident atrial fibrillation (AF) risk. However, it remains unclear whether AI provides meaningful and generalizable (...) (Circulation)
• 10:00
  Community-Level Economic Distress, Race, and Risk of Adverse Outcomes After Heart Failure Hospitalization Among Medicare Beneficiaries - Amgad Mentias Milind Y. Desai Mary S. Vaughan-Sarrazin Shreya Rao Alanna A. Morris Jennifer L. Hall Venu Menon Jason Hockenberry Mario Sims Gregg C. Fonarow Saket Girotra Ambarish Pandey Heart, Thoracic, and Vascular Institute, Cleveland Clinic Foundation, OH (A.M., M.Y.D., V.M.). Center for Access and Delivery Research and Evaluation, Iowa City Veterans Affairs Medical Center (M.S.V.-S., S.G.). Department of Internal Medicine (M.S.V.-S., S.G.), Carver College of Medicine, The University of Iowa, Iowa City. Division of Cardiovascular Diseases, Department of Internal Medicine (S.G.), (...) Circulation
  Circulation, Volume 145, Issue 2, Page 110-121, January 11, 2022. Background:Socioeconomic disadvantage is a strong determinant of adverse outcomes in patients with heart failure. However, the contribution of community-level economic distress to adverse outcomes in heart failure may differ (...) (Circulation)
• 10:02
  Energetic Basis for Exercise-Induced Pulmonary Congestion in Heart Failure With Preserved Ejection Fraction - Matthew K. Burrage Moritz Hundertmark Ladislav Valkovi? William D. Watson Jennifer Rayner Nikant Sabharwal Vanessa M. Ferreira Stefan Neubauer Jack J. Miller Oliver J. Rider Andrew J.M. Lewis University of Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine (M.K.B., M.H., L.V., W.D.W., J.R., V.M.F., S.N., O.J.R., A.J.M.L.), University of Oxford, UK. Department of Physics, Clarendon Laboratory (J.J.M.), University of Oxford, UK. Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia (L.V.). (...) Circulation
  Circulation, Volume 144, Issue 21, Page 1664-1678, November 23, 2021. Background:Transient pulmonary congestion during exercise is emerging as an important determinant of reduced exercise capacity in heart failure with preserved ejection fraction (HFpEF). We sought to determine whether an (...) (Circulation)
• 10:00
  National Trends and Disparities in Hospitalization for Acute Hypertension Among Medicare Beneficiaries (1999–2019) - Yuan Lu Yun Wang Erica S. Spatz Oyere Onuma Khurram Nasir Fatima Rodriguez Karol E. Watson Harlan M. Krumholz Center for Outcomes Research and Evaluation, Yale New Haven Hospital, CT (Y.L., Y.W., E.S.S., O.O. H.M.K.). Section of Cardiovascular Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT (Y.L., E.S.S., O.O. H.M.K.). Richard and Susan Smith Center for Outcomes Research in Cardiology, Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (Y.W.). Division of Cardiovascular Prevention and Wellness, Houston Methodist (...) Circulation
  Circulation, Volume 144, Issue 21, Page 1683-1693, November 23, 2021. Background:In the past 2 decades, hypertension control in the US population has not improved and there are widening disparities. Little is known about progress in reducing hospitalizations for acute hypertension.Methods:We (...) (Circulation)
• 10:00
  Unmasking Nonpreserved Heart Structure, Function, and Energetics in Heart Failure With Preserved Ejection Fraction With Magnetic Resonance Imaging Coupled With Exercise - Jennifer E. Ho Christopher Nguyen Gregory D. Lewis Division of Cardiology, Massachusetts General Hospital, Boston (J.E.H., G.D.L). Cardiovascular Research Center (J.E.H., C.N), Massachusetts General Hospital, Harvard Medical School, Charlestown. Martinos Center of Biomedical Imaging (C.N.), Massachusetts General Hospital, Harvard Medical School, Charlestown. Health Science Technology, Massachusetts Institute of Technology, Cambridge (C.N.). Circulation
  Circulation, Volume 144, Issue 21, Page 1679-1682, November 23, 2021. (Circulation)
• 11:42
  Abstract 9458: Nutritional Status Determines Early versus Late Deaths in Patients With Heart Failure With Preserved Ejection Fraction -Insights from the PURSUIT-HFPEF Registry- - Masato Okada Nobuaki Tanaka Toshinari Onishi Katsuomi Iwakura Masahiro Seo Masamichi Yano Takaharu Hayashi Nakagawa Akito Yusuke Nakagawa Shunsuke Tamaki Takahisa Yamada Yoshio Yasumura Yohei Sotomi Shungo Hikoso Yasushi Sakata Sakurabashi Watanabe Hosp, Osaka, Japan Cardiovascular Cntr, Sakurabashi Watanabe Hosp, Osaka, Japan Sakurabashi Waturahe Hospi, Osaka, Japan Div of Cardiology, Osaka General Med Cntr, Osaka, Japan Div of Cardiology, Osaka Rosai Hosp, Osaka, Japan Cardiovascular Div, Osaka Police Hosp, Osaka, Japan Div of Cardiology, Amagasaki Chuo Hosp, Osaka, Japan Div of (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9458-A9458, November 16, 2021. Introduction:Understanding how patients with heart failure with preserved ejection fraction (HFpEF) die provides insight into the natural history and pathophysiology of this complex syndrome. Factors that influence (...) (Circulation)
• 11:42
  Abstract 9459: Cardiac Troponin I and the Risk of Cardiovascular or Non-Cardiovascular Death in Patients Visiting Emergency Department - Jong Eun Park Jin-Ho Choi Sung Yeon Hwang Minseok Song Samsung Med Cntr, Seoul, Korea, Republic of Samsung Med Cntr, Seoul Seoul SAMSUNG MEDICAL CENTER, Seoul Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9459-A9459, November 16, 2021. Background:To identify the magnitude and temporal relationship between cardiac troponin I (TnI) and the risk of cardiac or non-cardiac death.Methods:Consecutive patients were included with maximal TnI value within 24 (...) (Circulation)
• 11:42
  Abstract 9460: Effects of Milk Fat Globule Epidermal Growth Factor VIII on Adverse Aortic Remodeling in Mice With Advancing Age - Mingyi Wang richard telljohann Leng Ni Wanqu ZHU Soo hyuk Kim Lijuan Liu JING ZHANG Kimberly McGraw Robert Monticone Christopher Morrell Edward G Lakatta National Institute on Aging, Baltimore, MD Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9460-A9460, November 16, 2021. Background:Milk fat globule epidermal growth factor VIII (MFG-E8), a secreted membrane glycoprotein, is an inflammatory signaling molecule, promoting the proliferation and invasion of vascular smooth muscle cells in (...) (Circulation)
• 11:42
  Abstract 9462: Emergency versus Delayed Coronary Angiogram in Survivors of Out-of-Hospital Cardiac Arrest Without St Segment Elevation: Results of the EMERGE Trial - Christian Spaulding Caroline Hauw-Berlemont Lionel Lamhaut Jean-Luc Diehl Christophe Andreotti Olivier Varenne Pierre Leroux Jean Baptiste Lascarrou Patrice GUERIN Thomas Loeb Eric Roupie Cedric Daubin Farzin Beygui Aurélie Vilfaillot Sophie Glippa Juliette Djadi-Prat Gilles Chatellier Alain Cariou European Hosp Georges Pompidou, Paris, France Intensive Care Medicine, European Hosp Georges Pompidou, Paris, France Hopital Necker, Paris, France Hôpital Cochin, Paris, France SAMU 44, CHU Nantes, Nantes, France CHU Nantes, Nantes, France CHU Nantes, Nantes, France Hôpital Ambroise Paré, Boulogne (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9462-A9462, November 16, 2021. Introduction:In adults, the most common cause of out-of-hospital cardiac arrests (OHCA) is coronary artery disease. If an immediate coronary angiogram (CAG) is recommended for survivors presenting a ST segment (...) (Circulation)
• 11:42
  Abstract 9463: Effects of Surgical and FFP2 Masks on Cardiopulmonary Exercise Capacity in Patients With Heart Failure - Alexander Kogel Pierre Hepp Tina Stegmann Adrienn Tuennemann-Tarr Roberto Falz Patrick Fischer Felix Mahfoud Ulrich Laufs Sven Fikenzer Klinik und Poliklinik für Kardiologie, UNIVERSITY HOSPITAL LEIPZIG, Leipzig Klinik und Poliklinik für Orthopädie, Unfallchirurgie und Plastische Chirurgie, UNIVERSITY HOSPITAL LEIPZIG, Leipzig UNIVERSITY HOSPITAL LEIPZIG, Leipzig Institute of Sport Medicine and Prevention, Univ Leipzig, Leipzig Klinik für Innere Medizin III, SAARLAND UNIVERSITY HOSPITAL, Homburg/Saar SAARLAND UNIVERSITY HOSPITAL, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9463-A9463, November 16, 2021. Introduction:Surgical and FFP2 masks are recommended to reduce transmission of SARS-CoV-2. The cardiopulmonary effects of facemasks in patients with chronic heart failure are unknown. This prospective, cross-over study (...) (Circulation)
• 11:42
  Abstract 9464: Left Ventricular Ejection Fraction Trajectory Predicts Outcomes in Patients With Heart Failure and Mildly Reduced Ejection Fraction - Robert J Miller Majid Nabipoor Erik Youngson Gynter Kotrri Nowell Fine Jonathan G Howlett Ian Paterson Justin Ezekowitz McAlister Finlay Cardiac Sciences, Univ of Calgary, Calgary, Canada Data and Rsch Services, Alberta Health Services, Calgary, Canada Dept of Cardiac Sciences, Univ of Calgary, Canada UNIVERSITY OF CALGARY, Calgary, Canada Foothills Hosp, Univ of Calgary, Edmonton, Canada Univ of Alberta UNIVERSITY OF ALBERTA, Edmonton, Canada Faculty of Medicine and Dentistry, Univ of Alberta, Edmonton, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9464-A9464, November 16, 2021. Introduction:Heart failure and mildly reduced ejection fraction (HFmrEF) is associated with a favourable prognosis compared heart failure with reduced EF. However, HFmrEF may be a transitory state and serial imaging (...) (Circulation)
• 11:42
  Abstract 9465: Does Connectedness Matter: The Association Between Mutuality and Job Satisfaction Among Home Health Aides Caring for Adults with Heart Failure - Ariel Shalev joanna Ringel Monika M Safford Barbara Riegel Emily Franzosa Ercole Vellone Emma Tsui Parag Goyal Michael Stawnychy Jennifer Reckrey Madeline R Sterling Weill Cornell Med College, New York, NY Weill Cornell Medicine, New York, NY Univ of Pennsylvania, Philadelphia, PA Icahn Sch of Medicine at Mount Sinai, New York, NY Univ of Rome Tor Vergata, Rome, Italy CUNY Graduate Sch of Public Health & Health Policy, New York, NY Weill Cornell Medicine, Pelham, NY The Mount Sinai Hosp, New York, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9465-A9465, November 16, 2021. Introduction:Adults with heart failure (HF) are increasingly aging in place and requiring help at home. However, due to poor compensation and the challenging nature of the work, home health aide (HHA) turnover rates (...) (Circulation)
• 11:42
  Abstract 9467: Prevalence of Chest Pain in Diabetics with Inflammatory Heart Disease - Deni Drenic Sathwika Thodeti Rohith Raghavendran Michael Yim J Ronald Mikolich Northeast Ohio Med Univ, Rootstown, OH Cardiology, Sharon Regional Med Cntr, Sharon, PA Northeast Ohio Med Univ Sharon Regional Med Cntr Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9467-A9467, November 16, 2021. Introduction:The deleterious effects of chronic or poorly controlled diabetes mellitus (DM) on the cardiovascular system are well documented, but the prevalence of chest pain associated with inflammatory heart disease (...) (Circulation)
• 11:42
  Abstract 9470: The Relative Risk of Cerebrovascular Accident in Patients With Von-Willebrand Disease - Abdulbaril Olagunju Nawfal Mihyawi Ayman R Fath Beani Forst Bikash Bhattarai Beeletsega T Yeneneh Internal medicine, Creighton Univ, Phoenix, AZ Cardiology, Creighton Univ, Phoenix, AZ Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9470-A9470, November 16, 2021. Introduction:Von Willebrand factor (vWF) is essential in platelet adhesion and aggregation. High concentration of vWF is associated with cerebrovascular accidents (CVA); however, it is yet unclear if its deficiency (...) (Circulation)
• 11:42
  Abstract 9472: Multicenter Comparison of Staged vs. Complete Repair in Young Infants With Tetralogy of Fallot with Pulmonary Atresia and Confluent Branch Pulmonary Arteries - Katerina Boucek Christopher Mastropietro Jonathan Beall Everette Keller Asaad Beshish Saul Flores Meghan Chlebowski Andrew R Yates Tarif Choudhury Dana Mueller David M Kwiatkowski Karl Migally Karan Karki Renee Willett Monique R Radman Chetana Reddy Kurt Piggott Christine Capone Yamini Kapileshwarkar Niranjan Vijayakumar Elizabeth Prentice Sukumar Suguna Narasimhulu Renee H Martin John M Costello Med Univ of South Carolina, Charleston, SC Indiana Univ SOM, Indianapolis, IN Children's Healthcare of Atlanta, GA Texas Children's Hosp, Houston, TX Cincinnati Children's Hosp, Cincinnati, OH (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9472-A9472, November 16, 2021. Introduction:Optimal management of neonates with tetralogy of Fallot and pulmonary atresia (TOF/PA) with confluent pulmonary arteries is unknown. We sought to compare outcomes for patients who underwent primary (...) (Circulation)
• 11:42
  Abstract 9473: Implications of Removal of the Race Coefficient from Estimated Glomerular Filtration Rate Calculation on Sodium Glucose Co-transporter-2 Inhibitors Eligibility in Heart Failure and/or Chronic Kidney Disease - Ramy Sedhom Eduardo Antonio Peter Abdelmaseeh Anantha Laxmi L vangapalli Hamza Akhtar Lucas Barreira Angelim Ardel J Romero Kevin Bryan Lo Roy O Mathew Muthiah Vaduganathan Janani Rangaswami Internal Medicine, Einstein Med Cntr, Philadelphia, PA Div of nephrology, Columbia VA Health Care System, Columbia, SC Cardiology, Brigham and Women’s Hosp, Harvard Med Sch, Boston, MA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9473-A9473, November 16, 2021. Introduction:The implications of race coefficient removal from the eGFR estimation equations on the pool of eligible Black patients with HFrEF and/or CKD for initiation of the Sodium Glucose Co-Transporter-2 inhibitors (...) (Circulation)
• 11:42
  Abstract 9474: Clinical and Epidemiologic Characterization of Infective Endocarditis in a Predominant Hispanic Community of the United States - Mexico Border - Ezhil Panneerselvam Jose Cruz Rodriguez Ruben Montanez Shristi Nepal ROHAN DESAI Kazue Okajima Internal Medicine, Texas Tech Univ Health Sciences Cntr El Paso, El Paso, TX El Paso, TX Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9474-A9474, November 16, 2021. Introduction:We aimed to characterize the clinical, epidemiological and echocardiographic features of infective endocarditis (IE) in the United States (US)-Mexico border population.Methods:A retrospective cohort design (...) (Circulation)
• 11:42
  Abstract 9476: Global Representation of Leaders, Collaborators, and Enrolled Participants in Heart Failure Clinical Trials: A Systematic Bibliometric Review - Jie Wei Zhu NhatChinh Le Sunny Wei Liesl Zuhlke Renato D Lopes Faiez Zannad Harriette G Van Spall Medicine, McMaster Univ, Hamilton, Canada Duke Clinical Rsch Institute, Durham, NC INSERM-CIC, Vandoeuvre Les Nancy, France McMaster Univ, Hamilton, Canada Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9476-A9476, November 16, 2021. Introduction:The geographic representation of investigators and participants in heart failure (HF) randomized clinical trials (RCTs) may not reflect the global burden of disease.Objectives:We assessed the geographic (...) (Circulation)
• 11:42
  Abstract 9477: Relation Between Coronary Artery Calcium Score and Clinical Outcomes After Percutaneous Coronary Intervention in Stable Coronary Artery Disease - Soichi Komaki Masanobu Ishii sou ikebe Ryota Kaichi Masafumi Takae Takayuki Mori Reiko Toida Kazumasa Kurogi Nobuyasu Yamamoto Kenichi Tsujita Koichi Kaikita Miyazaki Prefectural NOBEOKA Hosp, Nobeoka, Miyazaki, Japan Kumamoto Univ, Kumamoto, Japan Univ of Miyazaki, Miyazaki, Japan Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9477-A9477, November 16, 2021. Introduction:Recently, some consensus on high bleeding and thrombotic risk has been reported in the management of patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). (...) (Circulation)
• 11:42
  Abstract 9479: Novel Predictors of Left Ventricular Reverse Remodeling in Patients With Recent-onset Dilated Cardiomyopathy Using T1 and T2 Mapping on Cardiac Magnetic Resonance - Ryo Yokoyama Yumiko Kanzaki Tomohiko Watanabe Masaaki Hoshiga Hirakata City Hosp, Hirakata, Japan Dept of Cardiology, Osaka Med and Pharmaceutical Univ, Takatsuki, Japan Osaka Med and Pharmaceutical Univ, Takatuski, Japan Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9479-A9479, November 16, 2021. Introduction:The prognosis of patients with idiopathic dilated cardiomyopathy (DCM) has improved in recent decades with guideline-directed medical therapy. There is an essential need for better biomarkers to predict (...) (Circulation)
• 11:42
  Abstract 9480: Vagus Nerve Stimulation Exerts Cardioprotection Against Doxorubicin-Induced Cardiotoxicity Through Improving Cardiac Mitochondrial Function and Autonomic Tone - Nanthip Prathumsap Benjamin Ongnok Thawatchai Khuanjing Apiwan Arinno Chayodom Maneechote Nattayaporn Apaijai Titikorn Chunchai Busarin Arunsak Sasiwan Kerdphoo Krekwit Shinlapawittayatorn Siriporn Chattipakorn Nipon Chattipakorn Chiang Mai Univ, Mueng ChiangMai, Thailand CERT center, Chiang Mai Univ, Chiangmai, Thailand CERT center, Chiang Mai, Thailand CERT Cntr, Chiang Mai, Thailand Chiang Mai, Thailand Chiang Mai Med Sch, Chiang Mai, Thailand Chiang Mai Univ, Chiang Mai, Thailand CHIANG MAI UNIVERSITY, Chiang Mai, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9480-A9480, November 16, 2021. Introduction:Cardiac sympathovagal imbalance is a common pathologic finding in patients receiving doxorubicin (DOX), and is considered as a cardiovascular risk factor. Growing evidence demonstrates that cardiac (...) (Circulation)
• 11:42
  Abstract 9481: Inhibition of Apoptosis and Ferroptosis Signaling Pathways Alleviates Myocardial Ischemia-Reperfusion Injury in Rats Through Modulation of Mitochondrial Function - Ying Luo Suchan Liao Jun Wu Chayodom Maneechote Busarin Arunsak Nattayaporn Apaijai Juthipong Benjanuwattra Siriporn Chattipakorn Nipon Chattipakorn Chiang Mai Univ, Chiang Mia, Thailand CHIANG MAI UNIVERSITY, Chiang Mai, Thailand CERT Cntr, Chiang Mai, Thailand Chiang Mai, Thailand Chiang Mai Univ, Chiang Mai, Thailand Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9481-A9481, November 16, 2021. Introduction:Apoptosis and ferroptosis have been implicated in cardiac ischemia/reperfusion (I/R) injury. Inhibitors of apoptosis (Z-VAD) and ferroptosis (FER-1) have been shown to protect the heart in several (...) (Circulation)
• 11:42
  Abstract 9483: Detection of Lipids by Near-infrared Spectroscopy in Calcified Coronary Plaques Containing Nodular Calcification: Insights from Multimodality Imaging and Histopathologic Assessment - Kota Murai Fumiyuki Otsuka Yu Kataoka Satoshi Kitahara Takamasa Iwai Kenichiro Sawada Hideo Matama Satoshi Honda Masashi FUJINO Shuichi Yoneda Kensuke Takagi Yasuhide Asaumi Kenichi Tsujita Teruo Noguchi Dept of Cardiovascular Medicine, National Cerebral and Cardiovascular Cntr, Suita, Osaka, Japan KUMAMOTO UNIV, Kumamoto Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9483-A9483, November 16, 2021. Introduction:Detection of lipids in coronary plaques by near-infrared spectroscopy (NIRS) is based on the absorbance of NIR light and can predict future coronary events. It remains unclear whether the ability of NIRS (...) (Circulation)
• 11:42
  Abstract 9484: Ferroptosis Inhibitors Reduce Brain Inflammation Due to Cardiac Ischemia/Reperfusion Injury in Rats - Suchan Liao Ying Luo Jun Wu Titikorn Chunchai Benjamin Ongnok Thawatchai Khuanjing Juthipong Benjanuwattra Nattayaporn Apaijai Nipon Chattipakorn Siriporn Chattipakorn Chiang Mai Univ, Thailand Chiang Mia, Thailand Chiang Mai, Thailand CERT center, Chiang Mai Univ, Chiangmai, Thailand CERT center, Chiang Mai, Thailand CERT Cntr, Chiang Mai, Thailand CHIANG MAI UNIVERSITY, Chiang Mai, Thailand Chiang Mai Univ, Chiang Mai, Thailand Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9484-A9484, November 16, 2021. Introduction:Brain inflammation and microglial hyperactivation are involved in the process of neuronal death including apoptosis, necroptosis, and ferroptosis, following cardiac and cerebral ischemia/reperfusion (I/R) (...) (Circulation)
• 11:42
  Abstract 9485: Hypertension Risk Differs by Ethnicity in Young Asian Women Independent of Cardiometabolic Conditions - Jerry Liu Kristine Gu Malini Chandra Lynn Guo Nancy P Gordon Joan C Lo Internal Medicine, Kaiser Permanente Oakland Med Cntr, Oakland, CA Kaiser Permanente Oakland Med Cntr, Oakland, CA Div of Rsch, KP Northern California, Oakland, CA Albany Med Sch, Albany, NY Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9485-A9485, November 16, 2021. Introduction:Prevalence of polycystic ovary syndrome (PCOS) and diabetes (DM), two cardiometabolic conditions (CMCs), vary by ethnicity in Asian women. Hypertension (HTN) also varies by ethnicity, but this has not been (...) (Circulation)
• 11:42
  Abstract 9486: Effect of Statin Therapy on Cognitive Decline and Incident Dementia in Older Adults - Zhen Zhou Joanne Ryan Michael E Ernst Sophia Zoungas Andrew M Tonkin Robyn L Woods John J McNeil Christopher Reid Andrea J Curtis Rory Wolfe Jo Wrigglesworth Raj C Shah Elsdon Storey Anne Murray Suzanne G Orchard Mark R Nelson Menzies Institute for Med Rsch, Univ of Tasmania, Hobart, Australia Sch of Public Health and Preventive Medicine, Monash Univ, Melbourne, Australia Dept of Pharmacy Practice and Science, College of Pharmacy, Univ of Iowa, Iowa City, IA Sch of Public Health, Curtin Univ, Australia Dept of Family Medicine and Rush Alzheimer's Disease Cntr, Rush Univ Med Cntr, Chicago, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9486-A9486, November 16, 2021. Background:The neurocognitive effect of statins in older adults remains uncertain.Objectives:To investigate the associations of statin use with cognitive decline and incident dementia among older adults.Methods:This (...) (Circulation)
• 11:42
  Abstract 9487: Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm - Chongyang Zhang Amy Mohan Hangchuan Shi Chen Yan Univ of Rochester, Rochester, NY Dept of Clinical & Translational Rsch, Univ of Rochester, Rochester, NY Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9487-A9487, November 16, 2021. Introduction:PDE5 plays a critical role in vascular smooth muscle cell (SMC) contraction by hydrolyzing 3’,5’ cyclic monophosphate (cGMP) and antagonizing cGMP-dependent protein kinase I (PKGI)-mediated vascular (...) (Circulation)
• 11:42
  Abstract 9489: Echocardiographic Characteristics, Cardiovascular Factors, and Disease-Directed Therapy Do Not Explain Differences in Covid-19 Related Hispanic Outcomes - Joseph Isaac S Wong Ramy Sadek Armeen Mehrabani Anthony Koppula Jonathan Soverow Cardiology, Olive View-UCLA Med Cntr, Sylmar, CA Olive View-UCLA Med Cntr, Sylmar, CA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9489-A9489, November 16, 2021. Introduction:Severe coronavirus disease 2019 (COVID-19) is associated with cardiovascular injury and disparate outcomes in different ethnic groups. However, the reason for this difference has not been (...) (Circulation)
• 11:42
  Abstract 9490: Home-Based Cardiac Rehabilitation During COVID-19 - Smitha Ganeshan Crystal Tse Alexis Beatty UCSF, San Francisco, CA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9490-A9490, November 16, 2021. Introduction:Cardiac rehabilitation (CR) reduces morbidity, hospitalizations, and mortality. Increasingly, digital tools have augmented the ease of delivering programs outside of the traditional rehabilitation center (...) (Circulation)
• 11:42
  Abstract 9492: Ventricular Tachycardia During Cardiopulmonary Exercise Testing in Hypertrophic Cardiomyopathy - Ibolya Csecs Darrell B Newman Marieke Nederend Kyle W Klarich Thomas G Allison Mayo Clinic, Rochester, MN CAHAL, Cntr for Congenital Heart Disease Amsterdam Leiden, Leiden, Netherlands MAYO CLINIC, Rochester, MN Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9492-A9492, November 16, 2021. Introduction and Hypothesis:In patients with hypertrophic cardiomyopathy (HCM), ventricular tachycardia (VT) is associated with adverse prognosis. Cardiopulmonary exercise testing (CPET) is part of the standard (...) (Circulation)
• 11:42
  Abstract 9493: Differences in Prognostic Implications of Changes in Echocardiography in Asymptomatic Severe Aortic Stenosis Managed Conservatively - Eri Muta Takao Kato Tomohiko Taniguchi Takeshi Kimura Kyoto, Japan KYOTO UNIVERSITY, Kyoto, Jordan Mitsubishi Kyoto Hosp, Kyoto, Japan Kyoto Univeristy, Kyoto Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9493-A9493, November 16, 2021. Background:No previous study has explored the association between the changes in echocardiographic parameters during follow-up and clinical outcomes in patients with asymptomatic severe aortic stenosis (AS) and who (...) (Circulation)
• 11:42
  Abstract 9495: Prognostic Value of Machine Learning on Clinical Parameters for Cardiac Prognosis in Patinets with Acute Congestive Heart Failure - Masato Shimizu Hiroko Miyazaki shummo cho Yoshiki Misu Ryo Tateishi Masao Yamaguchi Yosuke Yamakami Hiroshi Shimada Tomoko Manno Ami Isshiki Shigeki Kimura Hiroyuki Fujii Makoto Suzuki Mitsuhiro Nishizaki Tetsuo Sasano YOKOHAMA MINAMI KYOSAI HOSPITAL, Yokohama, Japan Dept of Cardiology, YOKOHAMA MINAMI KYOSAI HOSPITAL, Yokohama, Japan Yokohama Minami Kyosai Hosp, Yakohama, Japan Yokohama Minami Kyosai, Yokohama, Kanagawa, Japan Yokohama Minami Kyosai Hosp, Yokohama Yokohama Minamikyosai Hosp, Yokohama-City, Japan Kanto Gakuin Univ, Yokohama, Japan TOKYO MEDICAL AND DENTAL UNIVERSITY, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9495-A9495, November 16, 2021. Introduction:Congestive heart failure (CHF) in acute phase, many clinical fundamental parameters including vital sign, laboratory data, or initial treatment were investigated, and we can roughly estimate the prognosis (...) (Circulation)
• 11:42
  Abstract 9496: 30-days Mortality Risk in the Patients Following Atrial Fibrillation Ablation in the Entire Nation of Poland: An 8-Year Analysis from National Health Fund of Poland - Michal Orczykowski Marcin Kowalski Valay K. Parikh Piotr Urbanek Bodalski Robert Pawel Derejko Grzegorz Warminski Andrzej Hasiec Krzysztof Dubowski Andrzej Glowniak Radoslaw Sierpinski Filip Urbanski Maria Bilinska Lukasz Szumowski National Institute of Cardiology, Warsaw, Poland Staten Island Univ Hosp, New York, NY Medicover Hosp, Warsaw, Poland Med Univeristy of Lublin, Lublin, Poland Med Rsch Agency, Warsaw, Poland National Health Fund, Warsaw, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9496-A9496, November 16, 2021. Introduction:Atrial fibrillation (AF) is the most common sustained arrhythmia. Catheter Ablation (CA) is considered as a first-line therapy for AF. The risk of 30-days all-cause mortality associated with CA for AF may (...) (Circulation)
• 11:42
  Abstract 9497: Dose Reduction of Ticagrelor in Ticagrelor Hyper-responders: A Pharmacokinetics and Pharmacodynamics (pkpd) Study - Ying ying Lin Doreen Tan CLIFF WONG Alan Fong LEE LEN TIONG Teck Kee Ang Patrick Zhan-Yun Lim Michael Liang Wan Xin Aw Syed Imran Khoo Teck Puat Hosp, Singapore Singapore Sarawak General Hosp, Malaysia Cardiology, Khoo Teck Puat Hosp, Singapore Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9497-A9497, November 16, 2021. Introduction:Ticagrelor has demonstrated superiority to Clopidogrel in reducing major adverse cardiovascular events, but at the cost of higher bleeding risk. However, the benefits were not replicated in the Asian (...) (Circulation)
• 11:42
  Abstract 9500: One-Year Safety and Effectiveness of Bivalirudin in Patients Undergoing Elective Percutaneous Coronary Intervention - Jiawen Li Yuejin Yang Jinqing Yuan Xueyan Zhao Beijing Beijing, China Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9500-A9500, November 16, 2021. Introduction:A lot of large studies (HORIZONS-AMI, BRIGHT, EUROMAX, etc.) have shown that bivalirudin in acute myocardial infarction patients undergoing primary percutaneous coronary intervention (PCI) could reduce the (...) (Circulation)
• 11:42
  Abstract 9501: Duration of Ideal Cardiovascular Health With Risk of Chronic Kidney Disease and Cardiovascular Disease - So Mi J Cho Justin Y Jeon Tae-Hyun Yoo Hae-young Lee Yong-ho Lee Hyeon Chang Kim Dept of Preventive Medicine, Yonsei Univ College of Medicine, Seoul Dept of Sports Industry Studies, Yonsei Univ, Seoul, Korea, Republic of Dept of Internal Medicine, Yonsei Univ College of Medicine, Seoul, Korea, Republic of SEOUL NATIONAL UNIV HOSP, Seoul Yonsei Univ College of Medici, Seoul Seoul Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9501-A9501, November 16, 2021. Introduction:Increasing number of clinical guidelines are adopting comprehensive cardiovascular risk assessment tools for treatment decision and disease management in the context of primary and secondary prevention. (...) (Circulation)
• 11:42
  Abstract 9505: Myocardial Energetic Impairment is the Basis for Reduced Cardiac Reserve and Exercise-Induced Pulmonary Congestion in Heart Failure With Preserved Ejection Fraction: Insights From Novel Cardiopulmonary Magnetic Resonance Imaging - Matthew K Burrage Moritz Hundertmark Ladislav Valkovic William D Watson Jennifer Rayner Nikant Sabharwal Vanessa Ferreira Stefan Neubauer Jack J Miller Andrew J Lewis Oliver J Rider Univ of Oxford Cntr for Clinical Magnetic Resonance Rsch, Univ of Oxford, Oxford, United Kingdom OCMR, Oxford Univ of Oxford, Oxford Dept of Cardiology, John Radcliffe Hosp, Oxford, United Kingdom UNIVERSITY OXFORD, Oxford Div of Cardiovascular Medicine, Oxford Dept of Physics, Univ of Oxford, Oxford, United Kingdom UNIVERSITY OF OXFORD, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9505-A9505, November 16, 2021. Introduction:Abnormal cardiac mitochondrial function and energetics may be a unifying feature in the pathogenesis of heart failure with preserved ejection fraction (HFpEF), while transient pulmonary congestion during (...) (Circulation)
• 11:42
  Abstract 9507: Evening Dosing of Antihypertensive Treatment is Not Associated With a Better Prognosis - Alejandro De La Sierra Luis M Ruilope Pablo Martinez-Camblor Ernest Vinyoles Manuel Gorostidi Julian Segura Bryan Williams HOSPITAL MUTUA TERRASSA, Terrassa, Spain Hosp 12 de Octubre, Madrid Univ of Darmouth, Hanover, NH CAP La Mina, Barcelona, Spain HOSPITAL General de Asturias, Oviedo, Spain HOSPITAL 12 de Octubre, Madrid, Spain Univ College London, London Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9507-A9507, November 16, 2021. Introduction:Night BP is the most powerful estimate of cardiovascular prognosis. It has been suggested that bedtime administration of antihypertensive therapy may favour night BP reduction and prognosis.Hypothesis:We (...) (Circulation)
• 11:42
  Abstract 9508: The Natural Product Zerumbone Suppresses Pressure Overload-Induced Cardiac Dysfunction by Inhibiting Cardiac Hypertrophy and Fibrosis - Mikuto Tojima Yasufumi Katanasaka Satoshi Shimizu Masafumi Funamoto Kana Shimizu Yoichi Sunagawa Koji Hasegawa Tatsuya Morimoto UNIVERSITY OF SHIZUOKA, Shizuoka, Japan Univ of shizuoka, shizuoka, Japan Univ of Shizuoka, Shizuoka, Japan KYOTO MEDICAL CENTER NHO, Kyoto Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9508-A9508, November 16, 2021. Introduction:Cardiac hypertrophy and fibrosis are hallmarks of cardiac remodeling and are involved functionally in the development of heart failure (HF). Various food components effectively prevent cardiovascular (...) (Circulation)
• 11:42
  Abstract 9509: Is Left Ventricular Lead Placement at Site of Latest Mechanical Activation Associated with Cardiac Resynchronization Therapy Outcomes? Results of a Meta-Analysis - Nancy M Allen Lapointe Fatima Ali-ahmed Frederik Dalgaard Andrzej S Kosinski Gillian D Sanders Sana M Al-Khatib Medicine, Duke Univ, Durham, NC Cardiology, Mayo Clinic, Rochester, MN Cardiology, GENTOFTE HOSPITAL, Hellerup, Denmark Duke Univ, NC Population Health Sciences, Duke Univ, Durham, NC DUKE UNIVERSITY MEDICAL CENTER, Durham, NC Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9509-A9509, November 16, 2021. Introduction:CRT outcomes with image-guided left ventricular (LV) lead placement within the LV segment of latest mechanical activation have been assessed in several randomized controlled trials (RCTs) with equivocal (...) (Circulation)
• 11:42
  Abstract 9510: How Dose Body Water Composition Change Around Cardiopulmonary Bypass Surgery of Children with Congenital Heart Disease? -Assessing by Bioelectrical Impedance Analysis - Haruka Obinata Satoshi Yasukochi Ryusuke Numata Kohsuke Yonehara Takeshi Konuma Yohei Akazawa Kohta Takei Kiyohiro Takigiku Dept of Pediatric cardiology, Nagano Children’s Hosp, Azumino, Japan Dept of cardiovascular surgery, Nagano Children’s Hosp, Azumino, Japan Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9510-A9510, November 16, 2021. Introduction:Although the management of body water balance on cardiac surgery with cardiopulmonary bypass (CPB), especially in children, is essential, little is known how body water composition changes around CPB. We (...) (Circulation)
• 11:42
  Abstract 9511: Implication of the KATP SUR2B/kir6.1 in the Physiopathology of Pulmonary Arterial Hypertension - Helene Le Ribeuz Mary Dutheil veronique capuano Olaf M Mercier Marc Humbert David Montani Fabrice Antigny U999, INSERM U999, Le Plessis Robinson, France U999, INSERM U999, Le plessis robinson, France MARIE LANNELONGUE HOSPITAL, Le Plessis Robinson, France Univ Paris Sud, Le Kremlin-Bicetre, France APHP HOPITAL BICETRE INSERM, Le Kremlin-bicetre, France INSERM U999, Le Plessis Robinson, France Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9511-A9511, November 16, 2021. Introduction:PAH is a severe and rare cardiopulmonary disease which is defined by an elevation of the mean pulmonary artery pressure >25mmHg. ABCC9 mutations are responsible of Cantu syndrome, a disease characterised (...) (Circulation)
• 11:42
  Abstract 9512: Involvement of Orai1 Ca2+Channel in the Pathogenesis of Pulmonary Arterial Hypertension. Orai1 as a New Potential Therapeutic Target? - Bastien Masson Helene Le Ribeuz Jessica Sabourin Emily Woodhouse Richard Foster Yann Ruchon Mary Dutheil Angele Boet Maria-Rosa Ghigna Olaf Mercier David J Beech Jean-Pierre Benitah marc bailey Marc Humbert David Montani veronique capuano Fabrice Antigny Hôpital Marie Lannelongue, INSERM U999, Le Plessis-Robinson, France Hôpital Marie Lannelongue, INSERM U999, Le Plessis Robinson, France Inserm UMR-S 1180, Châtenay-Malabry, France Institute of Cardiovascular and Metabolic Medicine, Leeds, United Kingdom Leeds, United Kingdom MARIE LANNELONGUE HOSPITAL, Le Plessis Robinson, France Univ of (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9512-A9512, November 16, 2021. Introduction:Pulmonary arterial hypertension (PAH) is a devastating disease, characterized by a progressive obstruction of distal pulmonary artery (PA) leading to right ventricular hypertrophy and failure. Exacerbated (...) (Circulation)
• 11:42
  Abstract 9515: Heterogeneity of Benefit on Quality of Life With an Invasive versus Conservative Strategy for Chronic Coronary Disease. Results From the ISCHEMIA Trial - Suzanne Arnold Philip Jones David J Maron Daniel B Mark Harmony R Reynolds Sripal Bangalore Jonathan D Newman Jiyan Chen Robert A Harrington David J Cohen Gregg W Stone Judith S Hochman John Spertus Saint Luke's Mid America Heart Institute/Univ of Missouri - Kansas City (UMKC), Kansas City, MO SAINT LUKES MID AMERICA HEART INST, Kansas City, MO STANFORD UNIVERSITY, Stanford, CA DUKE UNIV MEDICAL CTR, Durham, NC NYU Grossman Sch of Medicine, New York, NY NEW YORK UNIVERSITY MEDICAL CENTER, New York, NY Guangdong Provincial People's Hosp, Guangzhou Cardiovascular Rsch Foundation, New York, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9515-A9515, November 16, 2021. Background:The ISCHEMIA trial recently showed that, on average, patients with chronic coronary disease (CCD) and at least moderate ischemia randomized to an invasive strategy (INV) reported less angina and better (...) (Circulation)
• 11:42
  Abstract 9516: Comparison of Mortality Rates Among Rate Control Agents in Patients With Atrial Fibrillation: A Systematic Review and Meta-Analysis - Angkawipa Trongtorsak Jakrin Kewcharoen Sakditad Saowapa Natchaya Polpichai Sittinun Thangjui Leenhapong Navaravong Internal Medicine, AMITA health Saint Francis Hosp, Evanston, IL Univ of Hawaii Internal Medic, Honolulu, HI Ramathibodi hospital, bangkok, Thailand Prince of Songkla Univ, Faculty of Medicine Songklanagarin Hosp, Thailand Bassett Healthcare Network, NY Univ of Utah Health, Salt lake City, UT Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9516-A9516, November 16, 2021. Introduction:Rate control strategy is an effective treatment strategy for patients with atrial fibrillation (AF). However, data supporting the selection of rate-control medications is still lacking. We conducted a (...) (Circulation)
• 11:42
  Abstract 9517: Under-Utilization of Conventional Guideline-Directed Medical Therapy Among Patients Eligible for the Recent Large-Scale Clinical Trials of Heart Failure With Reduced Ejection Fraction - Satoshi Shoji Shun Kohsaka Yasuyuki Shiraishi Mitsuaki Sawano Nobuhiro Ikemura Nozomi Niimi Takashi Kohno Ayumi Goda Yuji Nagatomo Mike Saji Makoto Takei Shintaro Nakano Keiichi Fukuda Tsutomu Yoshikawa KEIO UNIVERSITY, Shinjyuku Tokyo KEIO UNIVERSITY, Tokyo Keio Univ Sch of Medicine, Tokyo, Japan Keio Univ, Tokyo, Japan KEIO UNIVERSITY SCHOOL OF MEDICINE, Tokyo, Japan Keio Univ, Tokyo KYORIN UNIVERSITY, Tokyo, Japan Kyorin Univ Hosipital, Tokyo, Japan National Defense Med College, Tokorozawa Univ of Virginia, charlottesville, VA Tokyo, Japan Hidaka, Japan SAKAKIBARA HEART INSTITUTE, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9517-A9517, November 16, 2021. Introduction:Recent large-scale clinical trials of novel heart failure (HF) agents (angiotensin receptor-neprilysin inhibitor, sodium-glucose cotransporter 2 inhibitor, and ivabradine) emphasize the use of baseline (...) (Circulation)
• 11:42
  Abstract 9521: Improvement of Left Ventricular Ejection Fraction After Surgical Revascularization in Patients Eligible for Implantable Cardioverter Defibrillator - Niyada Naksuk Selma Carlson Amy Gravely Melissa Buelt-Gebhardt Mohammad Madjid Selcuk Adabag Internal Medicine, Div of Cardiovascular Medicine, Univ of Nebraska Med Cntr, Omaha, NE Minneapolis, MN Minneapolis VA Med Cntr, Minneapolis, MN Minneapolis VA Health Care System, Minneapolis, MN UTHealth, Houston, TX MINNEAPOLIS VA MEDICAL CENTER, Minneapolis, MN Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9521-A9521, November 16, 2021. Introduction:Left ventricular ejection fraction (LVEF) ?35% is the cornerstone criterion for implantable cardioverter-defibrillator (ICD) eligibility. But improvement in LVEF may occur in ICD-eligible patients after (...) (Circulation)
• 11:42
  Abstract 9523: Substituting Deep Learning Chest X-Ray Age for Chronological Age in the Pooled Cohort Equations - Vineet K Raghu jakob weiss Kaavya Paruchuri Pradeep Natarajan Hugo Aerts Udo Hoffmann Michael T Lu Radiology, Massachusetts General Hosp, Boston, MA DFCI, Boston, MA Massachusetts General Hosp, Boston, MA MASSACHUSETTS GENERAL HOSPITAL, Boston, MA Harvard-DFCI, Boston, MA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9523-A9523, November 16, 2021. Introduction:Statin eligibility for primary prevention is based on the Pooled Cohort Equations (PCE) 10-year atherosclerotic cardiovascular disease risk calculator. A critical risk factor in the PCE is chronological (...) (Circulation)
• 11:42
  Abstract 9524: The Challenge of Treating a Previously Surgical Revascularized Patient With Acute ST-Elevation Myocardial Infarction (STEMI) and Coronary-Subclavian Steal Syndrome - Henrique Trombini Pinesi Pedro H Marins Hadrien F Balzan Fabio Cetinic Habrum Bruna R Matuck Marina A de Medeiros Fabio G Pitta Eduardo G Lima Cibele L Garzillo Carlos V Serrano Atherosclerosis, Instituto do Coracao HCFMUSP, Sao Paulo, Brazil Instituto do Coracao HCFMUSP, Sao Paulo, Brazil Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9524-A9524, November 16, 2021. Introduction:Coronary-subclavian steal syndrome (CSSS) is a rare cause of myocardial ischemia after coronary artery bypass grafting (CABG), due to significant stenosis of the proximal portion of the left subclavian (...) (Circulation)
• 11:42
  Abstract 9526: Fto Demethylase Mediates Altered N6-methyladenosine (m6a)-rna Modification in Human Failing Heart and Stressed-Induced Rat Cardiomyocytes - Praveen K Dubey Shubham Dubey Mallikarjun Patil Sarojini Singh Paras Ahuja Steven pogwizd Prasanna Krishnamurthy Biomedical Engineering, Univ of Alabama at Birmingham, Birmingham, AL Dept of BiomedicalEngineering, Univ of Alabama at Birmingham, Birmingham, AL Univ of Alabama at Birmingham, Birmingham, AL Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9526-A9526, November 16, 2021. Background:N6-methyladenosine (m6A) methylation is one of the important posttranscriptional modification of RNA, which affects RNA splicing, translation and stability. These modifications are dynamically regulated by (...) (Circulation)
• 11:42
  Abstract 9528: Apical Resection in Newborn Pig Hearts Extends the Regenerative Window of Cardiomyocyte - Yuji Nakada Yang Zhou Wuming Gong Erik Skie Eric Y Zhang Thanh Nguyen Yuhua Wei Meng Zhao Wangping Chen Jiacheng Sun Jake Y Chen Greg P Walcott Daniel J Garry Jianyi Zhang Univ of Alabama at Birmingham, Birmingham, AL Univ of Univ of Minnesota, Minneapolis, MN Lillehei Heart Institute, Minneapolis, MN LILLEHEI HEART INSTITUTE - U OF MN, Minneapolis, MN UNIVERSITY OF ALABAMA AT BIRMINGHAM, Birmingham, AL Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9528-A9528, November 16, 2021. Background:The neonatal porcine heart possesses proliferative cardiomyocyte capacity to recover heart function and structure after an acute myocardial injury during two days of birth. In this study, we have extended (...) (Circulation)
• 11:42
  Abstract 9530: Plaque Rupture, Compared to Plaque Erosion, is Associated With Higher Level of Pan-Coronary Inflammation, Measured by Peri-Coronary Adipose Tissue Attenuation on Coronary Computed Tomography Angiography - Akihiro Nakajima Tomoyo Sugiyama Makoto Araki Lena M Seegers Damini Dey Iris McNulty Hang Lee Taishi Yonetsu Yumi Yasui Yun Teng Tatsuhiro Nagamine Sunao Nakamura Stephan Achenbach Tsunekazu Kakuta Ik-kyung Jang Massachusetts General Hosp, Boston, MA Dept of Cardiology, Tsuchiura Kyodo General Hosp, Tsuchiura, Japan 8700 Beverly Blvd, Los Angeles, CA Tokyo Med and Dental Univ, Tokyo Tsuchiura Kyodo General Hosp, Tsuchiura, Japan NEW TOKYO HOSPITAL, Chiba, Japan Univ of Erlangen, Erlangen TSUCHIURA KYODO GENERAL HOSPITAL, Tsuchiura, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9530-A9530, November 16, 2021. Introduction:Vascular inflammation plays a key role in plaque rupture, while the role of inflammation in plaque erosion remains less well defined. Peri-coronary adipose tissue attenuation (PCATA) has emerged as a (...) (Circulation)
• 11:42
  Abstract 9531: Septin4 Deletion Prevents Hypertrophy to Heart Failure Transition After Transverse Aortic Constriction - Dogacan Yucel Preethy Parthiban An Xie Jop H Van Berlo Univ of Minnesota, Minneapolis, MN UNIV OF MN DIV CARDIOLOGY, Minneapolis, MN Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9531-A9531, November 16, 2021. Introduction:In response to cardiac injury or increased workload, the mammalian heart undergoes ventricular remodeling to maintain cardiac function. Initially, these changes are compensatory, although ultimately, they (...) (Circulation)
• 11:42
  Abstract 9533: ‘Youthful’ Phenotype of C-kit+ Cardiac Fibroblasts - Fareheh Firouzi Oscar H Echeagaray Carolina Y Esquer Natalie A Gude Mark A Sussman San Diego State Univ, San Diego, CA San Diego State Univ, CA SDSU RESEARCH FOUNDATION, San Diego, CA SAN DIEGO STATE UNIVERSITY, San Diego, CA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9533-A9533, November 16, 2021. Introduction:Fibroblasts are critical contributors to myocardial development, tissue homeostasis and remodeling. Cardiac fibroblast population heterogeneity and plasticity present a challenge for categorization of (...) (Circulation)
• 11:42
  Abstract 9534: Proteomic Signature of Right Ventricular Failure in Pulmonary Arterial Hypertension - Tetsuro Yokokawa Tsukasa Shimauchi Sandra B Bonnet francois Potus Roxane Paulin Steeve Provencher Sebastien Bonnet Olivier BOUCHERAT Groupe de recherche en hypertension artérielle pulmonaire, Université Laval, Québec (Qc), Canada Laval Univ, Quebec, Canada Québec, Canada Heart and Lung Institute, Quebec, Canada Laval Univ Quebec Heart and Lung institute, Quebec, Canada IUCPQ RESEARCH CENTRE, Quebec, Canada Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9534-A9534, November 16, 2021. Background:Pulmonary arterial hypertension (PAH) is a vascular remodeling disease leading to pulmonary artery pressure elevation and right ventricular (RV) failure. RV failure is the principal determinant of adverse (...) (Circulation)
• 11:42
  Abstract 9536: Prediction of Drug-Induced QTc Prolongation With an ECG Based Machine Learning Model - Thomas Morland Sushravya Raghunath Christopher R Kelsey Jeffrey Ruhl Steven R Steinhubl Mariya P Monfette John Pfeifer Ruijun Chen Noah Zimmerman Brian P Delisle Randle Storm Christopher M Haggerty Brandon Fornwalt Geisinger Health System, Danville, PA Scripps Rsch Translational Scie, La Jolla, CA Lewisburg, PA Geisinger, Fort Lee, NJ Redwood City, CA UNIVERSITY OF KENTUCKY, Lexington, KY Geisinger, Danville, PA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9536-A9536, November 16, 2021. Introduction:Initiation of QTc-prolonging medications may lead to the rare but potentially catastrophic event, torsades de pointes (TDP). At present, no adequate, generalizable tools exist to predict drug-induced long (...) (Circulation)
• 11:42
  Abstract 9538: Comparison of Central Aortic Pressures Obtained Using an Invasive Pressure Catheter and the Noninvasive Sphygmocor Device - Cara Esposito Priscilla Machado Ira Cohen Praveen Mehrotra Michael P Savage David L Fischman Marguerite Davis Nicholas J Ruggiero Paul Walinsky Maureen McDonald Kristopher Dickie Flemming Forsberg Jaydev K Dave Thomas Jefferson Univ, Philadelphia, PA Thomas Jefferson Univ, philadelphia, PA Clarius Mobile Health, Vancouver, Canada Radiology, Thomas Jefferson Univ, Philadelphia, PA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9538-A9538, November 16, 2021. Introduction:The SphygmoCor (ATCOR, Naperville, IL) device utilizes a generalized transfer function based on patient’s age and gender to derive the aortic pressure pulse from the brachial-cuff based pressure (...) (Circulation)
• 11:42
  Abstract 9539: Treatment of Hyperlipidemia: Assessment of Providers’ Competency With Edocate® Virtual Patient Simulation Application - Igal Iancu Boris DRAZNIN Edocate Ltd., Tel Aviv, Israel Univ of Colorado Anschutz Med Campus, Aurora, CO Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9539-A9539, November 16, 2021. Management of hyperlipidemia (HL) in patients with Type 2 diabetes (T2DM) has been taught extensively but the real-life competency is difficult to evaluate. Edocate’s proprietary virtual patient simulation smartphone (...) (Circulation)
• 11:42
  Abstract 9541: Sex Disparities in In-Hospital Outcomes of Left Ventricular Aneurysm Complicating Acute Myocardial Infarction: A United States Nationwide Analysis - Venkata Siva Kumar Pajjuru Abhishek Thandra Ryan Walters Bhavani Nagendra N Papudesi Saraschandra Vallabhajosyula Venkata M Alla Andrew M Goldsweig Internal Medicine, Creighton Univ Sch of Medicine, Omaha, NE Creighton Univ, Omaha, NE East Norriton, PA Emory Univ Sch of Medicine, Decatur, GA Cardiovascular diseases, Creighton Univ Sch of Medicine, Omaha, NE Univ of Nebraska Med Cntr, Omaha, NE Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9541-A9541, November 16, 2021. Background:Previous studies have reported sex-specific differences in the presentation, mechanisms, and outcomes of acute myocardial infarction (AMI).Objective:To assess differences in the incidence and in-hospital (...) (Circulation)
• 11:42
  Abstract 9544: Physical Activity in Individuals With Hypertrophic Cardiomyopathy: Baseline Data From the Prospective "Lifestyle and Exercise in Hcm" (live-hcm) Study - Rachel Lampert Michael J Ackerman Bradley S Marino Matthew Burg Barbara Ainsworth Lisa Salberg Maite Tome Seshadri Balaji Carolyn Ho Richard J Czosek Cynthia James Michael Emery Robert Cooper Martijn Bos Jeffrey B Geske Lubna Choudhury Susan P Etheridge Ashwin K Lal James S Ware Anne M Dubin Belinda Gray Silvana M Molossi Martin S Maron Sara Saberi Daniel L Jacoby Benjamin W Eidem Kimberly Harmon Kevin Hall Brian Olshansky Mark S Link Ian Law Elizabeth V Saarel N A Estes Barry Maron David S Cannom Fangyong Li Kaylie Briske Laura Simone Cheryl Barth Maryann Concannon Sharlene Day YALE SCH (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9544-A9544, November 16, 2021. Introduction:Safety of vigorous exercise for individuals with appropriately-treated HCM remains debated. Physical activity practices in this population have not been described. The objective of this report is to (...) (Circulation)
• 11:42
  Abstract 9545: Indexing Mitral Regurgitant Volume to Left Ventricular Cavity Size Improves Prognostication of Mortality - Jordan B Strom Marwa Sabe A. Reshad Garan Jason D Matos Kamal R Khabbaz Lawrence Markson Warren J Manning Richard A. and Susan F. Smith Cntr for Outcomes Rsch in Cardiology, Boston, MA Cardiovascular Medicine, Beth Israel Deaconss Med Cntr, Boston, MA Beth Israel Deaconess Med Cntr, Boston, MA Beth Israel Deaconsess Med Cntr, Boston, MA Beth Israel Deaconess Med Cente, Boston, MA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9545-A9545, November 16, 2021. Background:Indexing mitral regurgitation (MR) regurgitation volume (RVol) for left ventricular (LV) cavity size accounts for concomitant LV remodeling, but whether it improves prognostication of mortality is (...) (Circulation)
• 11:42
  Abstract 9546: Cancer Therapeutics-Related Cardiac Dysfunction is Associated With High Risk of Cancer-Related Mortality in Patients Treated With Anthracycline-Containing Chemotherapy - Masayoshi Oikawa Daiki Yaegashi Sayoko Yokokawa Tetsuro Yokokawa Tomofumi Misaka Takamasa Sato Takashi Kaneshiro ATSUSHI KOBAYASHI Akiomi Yoshihisa Kazuhiko Nakazato Takafumi Ishida Yasuchika Takeishi Dept of Cardiovascular Medicine, FUKUSHIMA MEDICAL UNIVERSITY, Fukushima, Japan FUKUSHIMA MEDICAL UNIV, Fukushima FUKUSHIMA MEDICAL UNIVERSITY, Fukushima, Japan FUKUSHIMA MEDICAL UNIV, Fukushima, Japan Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9546-A9546, November 16, 2021. Background:Cancer therapeutics-related cardiac dysfunction (CTRCD) is a concerning problem in anthracycline-containing chemotherapy. However, the impact of CTRCD on cancer-related mortality is remained to be (...) (Circulation)
• 11:42
  Abstract 9547: Prevalence and Characteristics of Registered Diabetes Clinical Trials With Cardiovascular Outcomes: An Analysis of Clinicaltrials.gov - Alexander R Zheutlin David Caldwell Alexander Chaitoff Joshua Niforatos Univ of Utah, Salt Lake Cty, UT Boston, MA Johns Hopkins Dept of Emergency Med, Baltimore, MD Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9547-A9547, November 16, 2021. Introduction:Cardiovascular disease (CVD) is a well-known sequela of diabetes. Interventions to address diabetes often fail to assess clinically-relevant cardiovascular event reduction. Recently, emphasis has shifted (...) (Circulation)
• 11:42
  Abstract 9548: De Novo Atypical Atrial Flutters: Locations, Mechanisms, and Long Term Outcomes Post Ablation - Alyssa Zaidi Jared Kirzner Christopher F Liu Jim W Cheung George Thomas James E Ip Bruce B Lerman Steven Markowitz Cardiology, Weill Cornell Med Cntr, New York, NY Weill Cornell Med College, New York, NY WEILL CORNELL MEDICAL COLLEGE, New York, NY CORNELL UNIVERSITY MEDICAL COLLEGE, New York, NY Weill Cornell Med Cntr, New York, NY WEILL MED CORNELL UNIV, New York, NY Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9548-A9548, November 16, 2021. Introduction:Atypical atrial flutter (aAFL) has been described in the absence of prior atrial interventions, but prognosis for these patients after catheter ablation is poorly defined. This study was designed to define (...) (Circulation)
• 11:42
  Abstract 9549: Role of Troponin Levels, Grace Score, and Timi Score in Predicting Mortality in Covid-19 Related Myocardial Injury - Kavin raj pranav mahajan Monarch Shah Jemin Jose Abi Watts Surya Kiran Aedma Swati Dhobale Riddhi Upadhyay Adam Rizkalla Suyansh Sharma rukhsaar khanam Talha Bin Farooq Patel Keval Randolph Martin Hasitha Manohar Saint Peter Univ Hosp, New brunswick, NJ Carle Foundation Hosp, Urbana, Illinois Saint Peter Univ Hosp Carle Foundation Hosp, Urbana, Illinois, IL Champaign, IL Cardiology, Saint Peter Univ Hosp, New brunswick, NJ Cardiology, Carle Foundation Hosp, Urbana, Illinois, IL Saint Peter Univ Hosp, New Brunswick, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9549-A9549, November 16, 2021. Introduction:COVID-19 infection is associated with troponin elevation, which is associated with increased mortality. We wanted to evaluate whether troponin levels, GRACE scores, and TIMI scores were independently (...) (Circulation)
• 11:42
  Abstract 9550: Sex and Ethnicity Specific Burden of Coronary Artery Calcium Among Middle-Aged and Older Adults: Multi-Ethnic Study of Atherosclerosis - Seamus P Whelton Omar Dzaye Alexander C Razavi Zeina Dardari Todd Villines Matthew J Budoff Roger S Blumenthal Robyn McClelland Michael J Blaha Khurram Nasir JOHNS HOPKINS UNIVERSITY, Baltimore, MD Emory Univ, Atlanta, GA Johns Hopkins Univ, carmel, IN Univ of Virginia Health System, Charlottesville, VA LOS ANGELES BIOMEDICAL RESEARC, Torrance, CA JOHNS HOPKINS HOSPITAL, Baltimore, MD Univ of Washington, Seattle, WA Houston Methodist, Houston, TX Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9550-A9550, November 16, 2021. Introduction:Detection of coronary artery calcium (CAC) at a low score is the ideal phase of the atherosclerotic process to start primary prevention therapies. A better understanding of how the proportion of (...) (Circulation)
• 11:42
  Abstract 9551: Presence of Disabilities is Associated With Reproductive Health Counseling, Concerns, and Experiences and Marital History Among Women With Congenital Heart Defects, 2016-2019 - Sherry L Farr Scott E Klewer Wendy N Nembhard Karrie F Downing Maureen Galindo Elijah H Bolin Argelia Benavides Ashley Judge Matthew Oster CDC, Atlanta, GA UINIVERSITY ARIZONA, Tucson, AZ UNIVERSITY OF ARKANSAS FOR MED SCI, Little Rock, AR Univ of Arizona, Tucson, AZ Univ of Arkansas, Little Rock, AR CDC, GA Children s Healthcare of Atlanta, Atlanta, GA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9551-A9551, November 16, 2021. Most females with congenital heart defects (CHD) will reach reproductive age. Our objective was to examine whether presence of disabilities is associated with reproductive health counseling, concerns, and experiences (...) (Circulation)
• 11:42
  Abstract 9552: RNA Sequencing of Cardiac and Renal Tissue in a Rat Model of Chronic Kidney Disease Reveals Chronodisruption as Common Pathway - Jef Van Den Eynde Xander Jacquemin Hilde Gillijns Willy Gsell Uwe Himmelreich Aernout Luttun Keir McCutcheon Stefan P Janssens Wouter Oosterlinck Dept of Cardiovascular Sciences, KU Leuven, Leuven, Belgium 3. MoSAIC, Biomedical MRI, Dept of Imaging and Pathology, KU Leuven, Leuven, Belgium Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9552-A9552, November 16, 2021. Introduction:Chronic kidney disease (CKD) is often accompanied by cardiovascular disease, which is referred to as type 4 cardiorenal syndrome. Management is challenging due to the multifactorial nature of the (...) (Circulation)
• 11:42
  Abstract 9555: A Mean Hemoglobin A1c Level of 7,5% is a Cliff Value for the Development of Cardiovascular Events in Diabetic Patients - Hirofumi Soejima Takeshi Morimoto Sadanori Okada Chisa Matsumoto Masafumi Nakayama Hideaki Jinnouchi Izuru Masuda Masako Waki Yoshihiko Saito Hisao Ogawa Kumamoto Univ, Kumamoto Hyogo College of Medicine, Nishinomiya Nara Med Univ, Kashihara, Japan Tokyo Med Univ Hosp, Tokyo, Japan Nakayama Cardiovascular Clinic, Amakusa, Japan Jinnouchi Hosp Diabetes Care Cntr, Kumamoto, Japan Takeda Hosp Med Examination Cntr, Kyoto, Japan Shizuoka City Shizuoka Hosp, Shizuoka, Japan Kumamoto Univ, Kumamoto, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9555-A9555, November 16, 2021. Background:We sought to evaluate whether there was a difference in the incidence rate of cardiovascular event (CVD) among different hemoglobin (Hb) A1c levels in diabetic patients without a history of atherosclerotic (...) (Circulation)
• 11:42
  Abstract 9556: Dipeptidyl Peptidase-4 Inhibitors Significantly Reduce the Incidence of First Cardiovascular Events in Diabetic Patients - Hirofumi Soejima Takeshi Morimoto Sadanori Okada Chisa Matsumoto Masafumi Nakayama Hideaki Jinnouchi Izuru Masuda Masako Waki Yoshihiko Saito Hisao Ogawa Kumamoto Univ, Kumamoto, Japan Hyogo College of Medicin, Nishinomiya, Japan Nara Med Univ, Kashihara, Japan Tokyo Med Univ Hosp, Tokyo, Japan Nakayama Cardiovascular Clinic, Amakusa, Japan Jinnouchi Hosp Daibetes Care Cntr, Kumamoto, Japan Takeda Hosp Med Examination Cntr, Kyoto, Japan Shizuoka City Shizuoka Hosp, Shizuoka, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9556-A9556, November 16, 2021. Background:Many studies have reported that dipeptidyl peptidase (DPP)-4 inhibitors do not significantly reduce cardiovascular events (CVE). We sought to evaluate whether DPP-4 inhibitors effected the incidence of CVE (...) (Circulation)
• 11:42
  Abstract 9557: Prognostic Significance of Serum Chloride Level in Patients With Acute Decompensated Heart Failure with Preserved Ejection Fraction: Insights from Pursuit-hfpef Registry - Masahiro Seo Takahisa Yamada Yoshio Yasumura Shungo Hikoso Yohei Sotomi Shunsuke Tamaki Masamichi Yano Takaharu Hayashi Akito Nakagawa Yusuke Nakagawa Yasushi Sakata Osaka General Med Cntr, Osaka City, Japan OSAKA GENERAL MEDICAL CENTER, Osaka Div of Cardiology, Amagasaki Chuo Hosp, Osaka City, Japan OSAKA UNIV GRAD SCHOOL OF MEDICINE, Suita, Japan Dept of Cardiovascular Medicine, Osaka Univ Graduate Sch of Medicine, Osaka City, Japan Rinku General Med Cntr, Izumisano 3-1179, Sakai, Japan Osaka Police Hosp, Osaka, Japan Amagasaki Chuo Hosp, Amagasaki, Japan Kawanishi, Japan OSAKA UNIV (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9557-A9557, November 16, 2021. Backgrounds:Prognostic value of serum chloride level has been reported mainly in patients with heart failure with reduced ejection fraction. Therefore, the evidence regarding the prognostic value of serum chloride (...) (Circulation)
• 11:42
  Abstract 9559: Clinical Outcomes and Predictors of All-Cause Mortality After Complex High-risk and Indicated Revascularization Using Percutaneous Coronary Intervention - Akinori Satake Yasuhiro Uchida Toyohashi, Japan YOKKAICHI MUNICIPAL HOSPITAL, Yokkaichi Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9559-A9559, November 16, 2021. Introduction:The concept of complex and high-risk indicated procedures using percutaneous coronary intervention (CHIP-PCI) has recently been defined. However, few studies have investigated the prognosis of patients (...) (Circulation)
• 11:42
  Abstract 9560: Identifying Best Practices for Education and Training of Resuscitation Teams for In-Hospital Cardiac Arrest - Theresa Anderson Sarah Krein Kayla Secrest Brad Trumpower Timothy Guetterman Molly Harrod Steven Kronick Richard J Schildhouse James Pribble Paul S Chan Brahmajee K Nallamothu Univ of Michigan, Ann Arbor, MI Ann Arbor, MI Veteran Affairs Hosp, Ann Arbor, MI Michigan Medicine, Ann Arbor, MI VA Ann Arbor Healthcare System, Ann Arbor, MI UNIV MICHIGAN INJURY RESEARCH CTR, Ann Arbor, MI MID AMERICA HEART INSTITUTE, Kansas City, MO UNIVERSITY MICHIGAN HEALTH SYSTEM, Ann Arbor, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9560-A9560, November 16, 2021. Background:In-hospital cardiac arrest (IHCA) leads to poor survival. Research suggests provider skills may play a role, but little is known on how education and training differ across hospitals.Methods:We conducted a (...) (Circulation)
• 11:42
  Abstract 9561: Loss of Full Length Pumilio 1 Abrogates Gene P27 Silencing-Mediated Cell Proliferation and Secures Mirna-221 Mimics Therapeutics in the Heart - Peipei Wang Yue Zhou Yu En Ng A Mark Richards NATIONAL UNIVERSITY OF SINGAPORE, Singapore National Univ of Singapore, Singapore NATIONAL UNIVERSITY OF SINGAPORE, Singapore, Singapore Medicine, National Univ of Singapore, Singapore Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9561-A9561, November 16, 2021. Introduction:MiR-221 mimics have been demonstrated to be cardioprotective and anti-fibrotic in the treatment of myocardium infarction and heart failure. However, miR-221 is a known oncomiR as the upregulation of (...) (Circulation)
• 11:42
  Abstract 9562: Prediction of Post-TAVR Pacemaker Implantation Using Machine Learning on Pre-TAVR ECG - Jamal Hajjari Takahiro Tsushima Scott Janus Heather Wheat Cristian R Baeza Sergio Thal Guilherme Attizzani Sadeer Al-Kindi Cardiology, Univ Hosps Cleveland Med Cntr, Cleveland, OH Univ Hosps CMC, Cleveland, OH Internal Medicine, Univ Hosps Cleveland Med Cntr, Cleveland, OH Cardiothoracic Surgery, Univ Hosps Cleveland Med Cntr, Cleveland, OH Univ Hosps Cleveland Med Cntr, Cleveland, OH Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9562-A9562, November 16, 2021. Introduction:Transcatheter Aortic Valve Replacement (TAVR) is increasingly performed with a decreasing overall complication rate. The risk of complete heart block requiring pacemaker implant (PPI) remains an important (...) (Circulation)
• 11:42
  Abstract 9563: Preventive Therapy Changes Following Coronary Computed Tomography Angiography versus Invasive Coronary Angiography in Patients With Nonobstructive Coronary Artery Disease - Nare Torosyan Brandon Schwartz Billy Chen Joseph Ebinger Heidi Gransar Alan Rozanski C N Bairey Merz Daniel Berman Cedars-Sinai Med Cntr, Los Angeles, CA Mount Sinai Morningside, New York, NY Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9563-A9563, November 16, 2021. Introduction:Coronary computed tomography angiography (CCTA) in SCOT-HEART led to increased preventive therapy for coronary artery disease (CAD). We hypothesized that atherosclerosis on CCTA would lead to greater (...) (Circulation)
• 11:42
  Abstract 9564: Zeb2 Shapes the Epigenetic Landscape of Atherosclerosis and Modulates the Risk of Myocardial Infarction - Paul Cheng Robert Wirka Quanyi Zhao Juyong B Kim Trieu Nguyen Shoa L CLARKE Ramendra K Kundu Disha Sharma Hyun-jung Kim Huitong Shi Themistocles L Assimes Thomas Quertermous STANFORD UNIVERSITY, Stanford, CA Stanford, CA Stanford Univ, palo alto, CA Stanford Univ, Stanford, CA Palo Alto, CA STANFORD UNIVERSITY, Palo Alto, CA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9564-A9564, November 16, 2021. Smooth muscle cells (SMC) transition into a number of different phenotypes during atherosclerosis, including those that resemble fibroblasts and chondrocytes, and make up the majority of cells in atherosclerotic (...) (Circulation)
• 11:42
  Abstract 9457: Safety and Feasibility of a Mixed Reality Head Mounted Display in the Cardiac Catheterization Laboratory - Johnny Chahine Stephen George Jason Bartos Ganesh Raveendran Sergey Gurevich Univ of Minnesota, Minneapolis, MN Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9457-A9457, November 16, 2021. Introduction:Mixed reality (MR) head-mounted displays (HMDs) have been used in a variety of industrial applications. The safety and feasibility of HMDs in cardiac catheterization laboratories (CCLs) for image and (...) (Circulation)
• 11:42
  Abstract 9400: Mitral Valve Prolapse Induces Regionalized Left Ventricular Fibrosis - Jordan E Morningstar Cortney Gensemer Reece Moore Diana B Fulmer Tyler Beck Christina Wang Kelsey Moore Lilong Guo Ayesha Vohra Franz Sieg Yasufumi Nagata Philippe Bertrand Ricardo Spampinato Janiece Glover Stephen Poelzing Robert G Gourdie William Richardson Robert A Levine Michael Borger Russell A Norris Dept of Regenerative Medicine and Cell Biology, Med Univ of South Carolina, Charleston, SC Dept of Regenerative Medicine and Cell Biology, Med Univ of South Carolina, SC Med Univ of SC, Charleston, SC Med Univ of South Carolin, Charleston, SC Dep, Med Univ of South Carolina, SC College (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9400-A9400, November 16, 2021. Introduction:Imaging studies patients with mitral valve prolapse (MVP) have previously shown cross sectional evidence of left ventricular (LV) fibrosis as well as increased risk for sudden cardiac death. This, along (...) (Circulation)
• 11:42
  Abstract 9401: Relationship Between Circulating Levels of Angiotensinogen and Hypertension—The Multi-Ethnic Study of Atherosclerosis - Patrick J Trainor Michela Brambatti Samantha M Carlisle Adam E Mullick Tanvir Kahlon Diana Otero Hossein Mousavi Erin Michos Pamela Ouyang Erin Morgan Yvonne Tami Sotirios Tsimikas Andrew P Defilippis New Mexico State Univ, Las Cruces, NM Ionis Pharmaceuticals Inc., Carlsbad, CA Ionis Pharmaceuticals, Inc., Carlsbad, CA Univ of Louisville, KY Johns Hopkins Univ, Baltimore, MD Univ of California, San Diego, La Jolla, CA Vanderbilt Univ Med Cente, Nashville, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9401-A9401, November 16, 2021. Introduction:Angiotensinogen (AGT) is a critical component of the renin-angiotensin-aldosterone system (RAAS) that regulates blood pressure (BP), volume, and electrolyte levels. While physiological effects of AGT are (...) (Circulation)
• 11:42
  Abstract 9402: Venous Thromboembolism During Pregnancy is Associated with Elevated Tricuspid Regurgitation Velocity in Sickle Cell Disease - William H Marshall Erin M Cleary Sherraine Della-Moretta Philip Samuels Payal Desai Saurabh Rajpal Wexner Med Cntr at the Ohio State Univ, Dept of Internal Medicine, Div of Cardiovascular Medicine, Columbus, OH Wexner Med Cntr at the Ohio State Univ, Dept of Obstetrics and Gynecology, Div of Maternal Fetal Medicine Wexner Med Cntr at the Ohio State Univ, Dept of Internal Medicine, Div of Hematology, Columbus, OH Wexner Med Cntr at the Ohio State Univ, Dept of Obstetrics and Gynecology, Div of Maternal Fetal Medicine, Columbus, OH Wexner Med Cntr at the Ohio State Univ, Dept of Internal (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9402-A9402, November 16, 2021. Introduction:In patients with sickle cell disease (SCD), a tricuspid regurgitation velocity (TRV) > 2.5 m/s by echocardiogram is a non-invasive marker for underlying pulmonary hypertension (PH), and associated with (...) (Circulation)
• 11:42
  Abstract 9404: Detecting Sars-cov-2 Orf3a and E Ion Channel Activity in Covid-19 Blood Samples - Hangang Yu Gina Sizemore Katy Smoot Peter Perrotta WEST VIRGINIA UNIVERSITY, Morgantown, WV Pathology, WEST VIRGINIA UNIVERSITY, Morgantown, WV Pathology, West Virginia Univ, WV Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9404-A9404, November 16, 2021. Introduction:SARS-CoV-2 has been found in the heart of COVID-19 patients. It is unclear how the virus passes from the upper respiratory tract to the myocardium.Hypothesis:SARS-CoV-2 is present in the blood of COVID-19 (...) (Circulation)
• 11:42
  Abstract 9407: Health Related Quality of Life in the Spironolactone to Reduce Icd Therapy (SPIRIT) Trial - Ana Carolina Sauer Liberato Merritt Raitt Ignatius G Zarraga Karen MacMurdy Cynthia M Dougherty Evidera PPD, Luxembourg, Luxembourg Portland VA Med Cntr, Portland, OR Cardiology, Portland VA Med Cntr, Portland, OR UNIV WASHINGTON SCHOOL NURSING, Seattle, WA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9407-A9407, November 16, 2021. Introduction:TheSpironolactone toReduceICDTherapy (SPIRIT) trial was designed to determine if once daily spironolactone would: 1) reduce the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF), (...) (Circulation)
• 11:42
  Abstract 9408: Serum and Urine Osmolality as Predictors of Adequate Diuresis in Acute Decompensated Heart Failure: A Prospective Cohort Study - Grace Salacup Kevin Lo Jerald Pelayo Prapaipan Putthapiban Ricardo Torres Mario Naranjo Janani Rangaswami Albert Einstein Med Cntr Philadelphia, Philadelphia, PA Loma Linda Univ, CA pulmonary critical care, Johns Hopkins Univ, MD Einstein Med Cntr ,, Jenkintown, PA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9408-A9408, November 16, 2021. Introduction:The utility of serum and urine osmolality in evaluating decongestion and outcomes in heart failure (HF) remain understudied.Methods:This is a prospective cohort single center study of patients with acute (...) (Circulation)
• 11:42
  Abstract 9412: Establishing a Coronary Calcium Scoring Threshold as a Gateway to Invasive Testing for Firefighters Undergoing Fitness for Duty Exams - Shiela C Beroukhim Afrahimi Shiela Beroukhim Afrahimi April Kinninger Matthew Budoff Harbor UCLA Med Cntr, Torrance, CA Harbor UCLA Med Cntr, Los Angeles, CA The Lundquist Ins., Torrance, CA Torrance, CA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9412-A9412, November 16, 2021. Introduction:Heart disease is the leading cause of death amongst active firefighters. Firefighters undergo exercise treadmill test as a part of fitness for duty examinations screening for heart disease. It has been (...) (Circulation)
• 11:42
  Abstract 9413: Quality Improvement for Improving Awareness of Cardiac Amyloidosis Among Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement (TAVR) - Dae Hyun Lee Arjun Khadilkar Rosalind Wheeler jennifer Bishop Bibhu D Mohanty FADI MATAR Hiram Bezerra Guilherme H Oliveira Joel Fernandez Univ of South Florida, Tampa, FL Cardiology, Tampa General Hosp, Tampa, FL Cardiology, Univ of South Florida, Tampa, FL Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9413-A9413, November 16, 2021. Introduction:Transthyretin cardiac amyloidosis (ATTR-CM) is an important comorbidity associated with aortic stenosis. Multiple studies have shown that the prevalence of ATTR-CM in severe AS is 15-20%. Concomitant AS (...) (Circulation)
• 11:42
  Abstract 9414: Utilization of Antithrombotic Therapies in Patients With Atrial Fibrillation Across the Spectrum of Stroke Risk - Xiaoxi Yao Ken Cohen Omar Latif Konstantinos Siontis Holly Van Houten Bernard J Gersh Neena Abraham Paul A FRIEDMAN Peter A Noseworthy Mayo Clinic, Rochester, MN OptumCare, Golden, CO Wilson, WY MAYO CLINIC, Rochester, MN Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9414-A9414, November 16, 2021. Introduction:OAC are recommended for AF patients with CHA2DS2-VASc ?2 in men or ?3 in women (high-risk group), may be considered in patients with CHA2DS2-VASc 1 in men or 2 in women (medium-risk group), and are (...) (Circulation)
• 11:42
  Abstract 9415: Body Mass Index, Waist Circumference and Waist-Hip Ratio in South Asians With Acute Coronary Syndrome - Parackrama Karunathilake Prabhashini Kumarihamy Sujeewa Gunaratne Dammika Ranasinghe Charith Bandara Udaya Ralapanawa Dept of Medicine, Faculty of Medicine, Univ of Peradeniya, Peradeniya, Sri Lanka Teaching Hosp, Peradeniya, Peradeniya, Sri Lanka Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9415-A9415, November 16, 2021. Introduction:Acute coronary syndrome (ACS) is the leading cause of death worldwide, even higher in South Asian countries. South Asia shows a higher incidence of ACS and an increasing trend of overweight and (...) (Circulation)
• 11:42
  Abstract 9416: Monocyte Subsets and Exercise Capacity in Patients With Atrial Fibrillation With Preserved Left Ventricular Function - farhan Shahid Gregory Lip Eduard Shantsila Cardiovascular Sciences, Univ of Birmingham, Birmingham Univ of Liverpool, Liverpool Univ of Birmingham Cntr for Cardiovascular Sciences, Birmingham Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9416-A9416, November 16, 2021. Introduction:Monocytes play important roles in inflammation, angiogenesis and tissue repair in cardiovascular disease. This study examined differences in monocyte subset numbers, subsequent markers of inflammation and (...) (Circulation)
• 11:42
  Abstract 9417: Prognostic Value and Predictors of Right Ventricular Dysfunction by Magnetic Resonance Imaging in Non-Ischemic Cardiomyopathy - Tom Wang Duygu Kocyigit Nicholas Chan Chris Anthony Jennifer Bullen Zoran B Popovic Wai Hong W Tang Brian P Griffin Scott D Flamm Deborah H Kwon Cleveland Clinic, Cleveland, OH Cleveland Clinic, Cleveland, Ankara, Turkey Cleveland CLinic, Cleveland, OH Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9417-A9417, November 16, 2021. Background:Challenges remain in our understanding of implications of right ventricle (RV) dysfunction in heart failure. Cardiac magnetic resonance imaging (CMR) is the reference standard for RV quantification, but has (...) (Circulation)
• 11:42
  Abstract 9418: Contrast Volume to Estimated Glomerular Filtration Rate Ratio as a Predictor for 30-Day All-Cause Mortality After Transcatheter Aortic Valve Implantation - Omar Chehab Clarissa Ng Yin Ling Samuel Hale Samuel Malomo Juliet C Berner Nanci O'Reilly Anthony Mathur Andreas Baumbach Mick Ozkor Simon Kennon Michael Mullen Cardiology, St Thomas' Hosp, London, United Kingdom King's College London, London, United Kingdom Cardiology, Barts Heart Cntr, London, United Kingdom Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9418-A9418, November 16, 2021. Introduction:Contrast-induced acute kidney injury (AKI) has been proven to be associated with early mortality and adverse events. However, in the setting of transcatheter aortic valve implantation (TAVI), previous (...) (Circulation)
• 11:42
  Abstract 9419: Quantification and Novel Algorithm of Echocardiography Against Magnetic Resonance Imaging for Isolated Tricuspid Regurgitation - Tom Wang Kevser Akyuz Reza Reyaldeen Zoran B Popovic Gosta B Pettersson A Gillinov Scott D Flamm Brian P Griffin Bo Xu Milind Y Desai Cleveland Clinic, Cleveland, OH Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9419-A9419, November 16, 2021. Background:Transthoracic echocardiography (TTE) is the first-line imaging modality to evaluate isolated tricuspid regurgitation (TR), however comparisons with magnetic resonance imaging (MRI) measurements have seldomly (...) (Circulation)
• 11:42
  Abstract 9420: A Striking Contrast Between Lipid Therapy Prescribing Patterns versus Achieving Optimal Lipid Levels in Black and Hispanic Populations Following Acute Coronary Events - Maxwell Ambrosino Sydney Emerson Patricia Hernandez Douglas Jacoby Internal Medicine, Pennsylvania Hosp of the Univ of Pennsylvania Health System, Philadelphia, PA Philadelphia, PA Perleman Sch of Medicine, Philadelphia, PA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9420-A9420, November 16, 2021. Introduction:Guideline directed lipid therapy (GDLT) for patients following acute coronary syndrome (ACS) is well-established secondary prevention. Historically disparities in secondary prevention have been observed (...) (Circulation)
• 11:42
  Abstract 9422: Assessment of Cardiotoxicity Following Thoracic Radiotherapy and Systemic Stem-Cell Derived Extracellular Vesicle Treatments - Ramin Badiyan Pierre Montay-Gruel Anjan S Batra Charles Limoli Pediatrics, Univ of California, Irvine, CA Univ of California, Irvine, CA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9422-A9422, November 16, 2021. Introduction:Radiotherapeutic management of certain cancers provides distinct benefits, but also results in variable degrees of cardiac exposure. Resultant radiation-induced heart disease (RIHD) typically manifests at (...) (Circulation)
• 11:42
  Abstract 9423: Virtual Reality (VR) Guided Telerobotic Cardiac Catheter Ablation is Feasible Over Low Bandwidth Network Connection - Stephen P Seslar Ryan C James Blake Hannaford Basil Saour Wayne Monsky Cardiology, Univ of Washington, Seattle, WA R&D, DOPL Technologies, Mukilteo, WA Dept of Electrical Engineering, Univ of Washington, Seattle, WA Electrophysiology, Advocate Heart Institute, Elgin, IL Interventional Radiology, Univ of Washington, Seattle, WA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9423-A9423, November 16, 2021. Introduction:Telerobotic operation in which a remote surgeon performs an operation over distance has long held the promise of providing a more equitable distribution of healthcare in rural and underserved regions of (...) (Circulation)
• 11:42
  Abstract 9424: Single versus Dual Antiplatelet Therapy for Stroke Prevention Following Left Atrial Appendage Occlusion in Patients With High Bleeding Risk - Mohammed Mhanna Azizullah Beran Ahmad Al-Abdouh Hazem Ayesh mahmoud Barbarawi Omar Srour Ziad Abuhelwa Wasef Sayeh Mahmoud Alsaiqali Ehab A Eltahawy Internal Medicine, The Univ of Toledo, Toledo, OH Saint Agnes Hosp, Baltimore, MD Univ of Connecticut, CT The Univ of Toledo, Toledo, OH Internal Medicine, State Univ of New York Downstate Med Cntr, Brooklyn, NY Cardiovascular Medicine, The Univ of Toledo, Toledo, OH Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9424-A9424, November 16, 2021. Introduction:The optimal antiplatelet therapy following Left atrial appendage occlusion (LAAO) in atrial fibrillation patients who are not candidates for long-term oral anticoagulation therapy (OAC) is subject to (...) (Circulation)
• 11:42
  Abstract 9425: Coronary Artery Calcium Measurement and Prediction of Cardiovascular Disease by Different Ct Scanner Types: The Multi-Ethnic Study of Atherosclerosis - Harpreet S Bhatia Isac C Thomas Julie Denenberg Matthew A Allison Robyn McClelland Matthew J Budoff Elliot McVeigh Michael H Criqui Univ of California San Diego, San Diego, CA UNIVERSITY OF CALIFORNIA SAN DIEGO, La Jolla, CA UCSD, La Jolla, CA Univ of California San Diego, La Jolla, CA Univ of Washington, Seattle, WA LOS ANGELES BIOMEDICAL RESEARC, Torrance, CA Medicine, Univ of California San Diego, San Diego, CA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9425-A9425, November 16, 2021. Introduction:Coronary artery calcium (CAC) scoring is a powerful tool for cardiovascular disease (CVD) risk prediction. The Agatston score weighs lesion area upward for density, and is consistent across computed (...) (Circulation)
• 11:42
  Abstract 9427: The Use of Cardiac Device Remote Monitoring in the Covid-19 Era of Telehealth Outpatient Medicine - Edmond Wong John Z Xie Kevin Rajakariar Kevin Masman Joris Mekel Voltaire Nadurata Cardiology, Bendigo Health, Bendigo, Australia Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9427-A9427, November 16, 2021. Background and Aim:During the Covid-19 pandemic, outpatient care has utilised telemedicine reviews for cardiac follow-up. We assessed the safety of remote monitoring in context with telehealth medicine for such (...) (Circulation)
• 11:42
  Abstract 9429: The Impact of Hypo-Attenuated Leaflet Thickening on Valvular Haemodynamics and Structural Valve Deterioration Following Transcatheter Aortic Valve Replacement - Hashrul Rashid Monash Health, Mulgrave, Australia Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9429-A9429, November 16, 2021. Introduction:Hypo-attenuated leaflet thickening (HALT) has been described following transcatheter aortic valve replacement (TAVR). It is unclear if HALT impacts prosthetic haemodynamics or predicts structural valve (...) (Circulation)
• 11:42
  Abstract 9430: A Novel Soluble Epoxide Hydrolase Peptide Vaccine Attenuates Cardiac Remodeling After Myocardial Infarction Through Angiogenesis - Takahiro Kitsuka Aya Shiraki Jun-ichi Oyama Hironori Nakagami Atsushi Tanaka Koichi Node Saga Univ, Saga, Japan Osaka Univ, Osaka, Japan Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9430-A9430, November 16, 2021. Introduction:Vaccination therapy has long-lasting effects and solves medication non-adherence. However, vaccination therapy on myocardial infarction (MI) has not been developed. Epoxyeicosatrienoic acids (EETs) play an (...) (Circulation)
• 11:42
  Abstract 9431: Preoperative Serum Gdf-15, Endothelin-1 Levels, and Intraoperative Factors as Short-Term Operative Risks for Patients Undergoing Cardiovascular Surgery - Takashi Kato Toshiaki Nakajima Taira Fukuda IKUKO SHIBASAKI Toshiyuki Kuwata Shigeru Toyoda Teruo Inoue Hirotsugu Fukuda Dept of Cardiovascular Surgery, Dokkyo Med Univ, Tochigi, Japan Dept of Cardiovascular Medicine, Dokkyo Med Univ, Tochigi, Japan Dept of Liberal Arts and Human Development, Kanagawa Univ of Human Services, Kanagawa, Japan Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9431-A9431, November 16, 2021. Introduction:The Society of Thoracic Surgeons (STS) risk score is widely used for the risk assessment of cardiac surgery. Serum biomarkers such as growth differentiation factor-15 (GDF-15) and endothelin-1 (ET-1) are (...) (Circulation)
• 11:42
  Abstract 9433: The Combination of the Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as a Novel Predictor of Cardiac Death in Acute Decompensated Heart Failure Patients With Preserved Left Ventricular Ejection Fraction: A Multicenter Study - Shunsuke Tamaki Yoshiyuki Nagai Ryu Shutta Daisaku Masuda Ryosuke Murai Shohei Yoshima Makoto Abe Koji Sako Shizuya Yamashita Masahiro Seo Takahisa Yamada Akito Nakagawa Yoshio Yasumura Yusuke Nakagawa Masamichi Yano Takaharu Hayashi Shungo Hikoso Yohei Sotomi Yasushi Sakata Rinku General Med Cntr, Izumisano, Japan Osaka General Med Cntr, Osaka, Japan Amagasaki Chuo Hosp, Amagasaki, Japan Kawanishi City Hosp, Kawanishi, Japan Osaka Rosai Hosp, Sakai, Japan Osaka Police Hosp, Osaka, Japan Dept of Cardiovascular Medicine, Osaka Univ Graduate Sch of Medicine, Suita, Japan Osaka Univ Graduate (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9433-A9433, November 16, 2021. Background:Inflammation plays a central role in the pathophysiology of heart failure (HF) with preserved ejection fraction (HFpEF). The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are (...) (Circulation)
• 11:42
  Abstract 9434: Cigarette Smoking and Incident Heart Failure With Preserved Ejection Fraction in African Americans: The Jackson Heart Study - Daisuke Kamimura Robert J Mentz Amil M Shah Adebamike A Oshunbade Arsalan Hamid Takeki Suzuki Donald Clark Ervin R Fox Adolfo Correa Javed Butler Michael E Hall Yokohama City Univ Hosp, Yokohama, Japan Duke Clinical Rsch Institute, Durham, NC BRIGHAM AND WOMEN S HOSPITAL, Boston, MA Univ of Mississippi Med C, Jackson, MS Cardiology, Univ of Mississippi Med Cntr, Jackson, MS Carmel, IN UNIVERSITY MISSISSIPPI MEDICAL CTR, Jackson, MS U OF MISSISSIPPI MEDICAL CENTER, Jackson, MS Univ of Mississippi, Jackson, MS UNIV OF MISSISSIPPI MEDICAL CENTER, Jackson, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9434-A9434, November 16, 2021. Background:Cigarette smoking has been associated with incident heart failure (HF), however the relationships with HF phenotypes have not been adequately investigated, particularly in African Americans.Methods and (...) (Circulation)
• 11:42
  Abstract 9435: An Ultrasound Image of Spleen Shear Wave Elastography Predicts Adverse Outcomes in Heart Failure Patients - Tomofumi Misaka Akiomi Yoshihisa Yasuhiro Ichijo Yukiko Sugawara Himika Ohara Yu Hotsuki Koichiro Watanabe Yu Sato Masayoshi Oikawa ATSUSHI KOBAYASHI Yasuchika Takeishi Fukushima Med Univ, Fukushima, Japan FUKUSHIMA MEDICAL UNIV, Fukushima fukushima, Japan Fukushima, Japan Fukushima Med Univ, Fukushima FUKUSHIMA MEDICAL UNIVERSITY, Fukushima, Japan FUKUSHIMA MEDICAL UNIV, Fukushima, Japan Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9435-A9435, November 16, 2021. Introduction:Cardiac and multiple organ network is involved in the pathophysiology of heart failure (HF). Ultrasound shear wave elastography (SWE) is a novel non-invasive imaging that is capable of quantitatively and (...) (Circulation)
• 11:42
  Abstract 9436: Impact of Pulmonary Artery Catheter Use in Cardiogenic Shock: A Systematic Review - Harsh Doshi Mahek Shah Alec Vishnevsky Jalaj Garg Rene Alvarez Thomas Jefferson Univ, PA Med College of Wisconsin, Milwaukee, WI Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9436-A9436, November 16, 2021. Introduction:Randomized controlled trials and systematic reviews evaluating the use of pulmonary artery catheters in the critically ill population have not shown beneficial effects on survival. However, many of those (...) (Circulation)
• 11:42
  Abstract 9437: Impact of Telemedicine Use on Blood Pressure Control During the Covid-19 Pandemic - Siqin Ye David E Anstey Anne K Grauer Gil Metser Nathalie Moise Joseph E Schwartz Ian M Kronish Marwah Abdalla Columbia Univ Med Cntr, New York, NY Columbia Univ, New York, NY Dept of Medicine, Columbia Univ Iring Med Cntr Stony Brook Univ, EAST SETAUKET, NY COLUMBIA UNIVERSITY, New York, NY Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9437-A9437, November 16, 2021. Background:Telemedicine use vastly expanded during the Covid-19 pandemic, with uncertain impact on cardiovascular care. quality.Objectives:To examine the association between telemedicine use and blood pressure (BP) (...) (Circulation)
• 11:42
  Abstract 9438: Unipolar Voltages Are Associated with Left Atrial Wall Thickness and Predict Atrial Fibrillation Recurrence After Pulmonary Vein Isolation - Masashi Kamioka Takafumi Okuyama Hiroaki Watanabe Ayako Yokota Tomonori Watanabe Takahiro Komori Tomoyuki Kabutoya Yasushi Imai Kazuomi Kario Jichi medical university, Shimotsuke-city, Japan Jichi Med Univ, Tochogi, Japan Tochigi, Japan Jichi Med Univ, Tochigi-ken Jichi Med Univ, Shimotsuke Tochigi JICHI MEDICAL UNIVERSITY, Tochigi-ken Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9438-A9438, November 16, 2021. Introduction:This study was conducted to investigate the relationship between left atrial (LA) wall thickness and the corresponding local unipolar/bipolar voltages, and its impact on the atrial fibrillation (AF) (...) (Circulation)
• 11:42
  Abstract 9440: Incidence, Charge, and Outcomes of Emergency Department Visits for Children with Single Ventricle Congenital Heart Disease from 2006-2018 - Jonathan B Edelson Monique Gardner Austin Kilaru Joseph Rossano Heather M Griffis Xuemei Zhang Jennifer Faerber Katie Dodds Matthew J O'Connor Chitra Ravishankar Jack Rychik David Goldberg Laura M Mercer-rosa Andrew C Glatz Kimberly Lin CHILDRENS HOSPITAL OF PHILADELPHIA, Philadelphia, PA Philadelphia, PA Children's Hosp of Philadelphia, Philadelphia, PA Univ of Pennsylvania, Philadelphia, PA Childrens Hosp of Philadelphia, Philadelphia, PA CHILDRENS HOSPITAL PHILADELPHIA, Philadelphia, PA Children's Hosp of Philadelphia, Swarthmore, PA CHOP, Philadelphia, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9440-A9440, November 16, 2021. Introduction:Children with single ventricle (SV) congenital heart disease have high morbidity, mortality and resource utilization when admitted to the hospital but few data exist on emergency department (ED) visits. (...) (Circulation)
• 11:42
  Abstract 9442: Acute Coronary Syndrome Treatment Delay in Low to Middle-Income Countries: A Systematic Review - Lemlem Demisse Sharon L. Leslie Bekele Alemayehu Gary Rebecca Addis Ababa Univ, Addis Ababa, Ethiopia Woodruff Health Sciences Cntr Library, Emory Univ, Atlanta, Georgia, Atlanta, GA Internal medicine, Addis Ababa Univ, Addis Ababa, Ethiopia Nell Hodgson Woodruff Sch of Nursing, Emory Univ, Atlanta, Georgia, Atlanta, GA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9442-A9442, November 16, 2021. Introduction:Although morbidity and mortality rates are declining for acute coronary syndrome (ACS) in most high-income countries, it is rising at an alarming pace for low to middle-income countries (LMICs), largely (...) (Circulation)
• 11:42
  Abstract 9443: Improving Time to Defibrillation Following Ventricular Fibrillation and Ventricular Tachycardia Cardiac Arrest at Thomas Jefferson University Hospital - Sairamya Bodempudi Lisa Wus Juergen Kloo Patrick Zeniecki Frances Mae West yair lev Thomas Jefferson Univ Hosp, Philadelphia, PA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9443-A9443, November 16, 2021. Problem Definition:Defibrillation within 2 minutes after ventricular fibrillation (VFib) and ventricular tachycardia (VTach) cardiac arrest has improved survival to discharge and five-year survival rates. The goal of (...) (Circulation)
• 11:42
  Abstract 9445: Gender Disparities in Statin Prescriptions Following Acute Coronary Syndrome - Sydney Emerson Maxwell Ambrosino Patricia Hernandez Douglas Jacoby Pennsylvania Hosp, Philadelphia, PA Philadelphia, PA Perleman Sch of Medicine, Philadelphia, PA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9445-A9445, November 16, 2021. Introduction:Initiation of high intensity statin therapy for patients following acute coronary syndrome (ACS) is well-established secondary prevention. Females with coronary artery disease have historically been (...) (Circulation)
• 11:42
  Abstract 9447: Hospital-level Disparities in Management and Outcomes of Cardiac Arrest Complicating Acute Myocardial Infarction - Venkata Siva Kumar S Pajjuru Sri Patlolla Pranathi R Sundaragiri Saraschandra Vallabhajosyula Internal Medicine, Creighton Univ Sch of Medicine, Omaha, NE MAYO CLINIC, Rochester, MN Mayo Clinic, Rochester, MN Emory Univ Sch of Medicine, Decatur, GA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9447-A9447, November 16, 2021. Background:There is limited contemporary data exploring the impact of hospital characteristics on the outcomes of AMI-CA patients.Methods:We used the National Inpatient Sample database (2000-2017), to identify adult (...) (Circulation)
• 11:42
  Abstract 9448: The Effect of Diabetes on Cardiovascular Events After Coronary Artery Bypass Grafting versus Drug-Eluting Stents for Left Main Coronary Artery Disease: A Meta-Analysis - Marc-Andre d'Entremont Ryuichiro Yagi Soziema J Salia Shuqi Zhang Lamyaa Shaban Yakubu Bene-Alhasan Stefania Papatheodorou Etienne L Couture Thao Huynh Michel Nguyen Rikuta Hamaya Div of Cardiology, Dept of Medicine, Sherbrooke Univ Hosp Cntr (CHUS), Sherbrooke, Canada Dept of Cardiology, Saiseikai Central Hosp, Tokyo, Japan Dept of Internal Medicine, Cape Coast Teaching Hosp, Cape Coast, Ghana Dept of Global Health and Population, Harvard T.H. Chan Sch of Public Health, Boston, MA Dept of Epidemiology, Harvard T.H. Chan Sch of Public Health, Boston, MA Dept of Cardiology, McGill Univ (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9448-A9448, November 16, 2021. Background:The optimal method of coronary revascularization for diabetes mellitus (DM) patients with left main coronary artery disease (LMCAD) is controversial in the drug-eluting stent (DES) era. We performed a (...) (Circulation)
• 11:42
  Abstract 9449: Extracorporeal Membrane Oxygenation versus Impella in Patients with Cardiogenic Shock from Inferior Wall Myocardial Infarction: Analysis from the National Inpatient Sample - Jashan Gill Ram Chandra Khatri Chhetri Rosalind Franklin Univ, McHenry, IL Rosalind Franklin Univ of Med Sciences, McHerny, IL Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9449-A9449, November 16, 2021. Introduction:Since the IABP-SHOCK II trial, extracorporeal membrane oxygenation (ECMO), and the percutaneous ventricular assist device, Impella have emerged as the preferred mechanical circulatory assist devices for (...) (Circulation)
• 11:42
  Abstract 9452: Artificial Intelligence for Predicting Human Age in ECG - ZHI-XUAN CHUO Ruey-Kang Chang QT Med, Inc., Taiwan Branch, Taipei, Taiwan QT Med, Inc., Diamond Bar, CA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9452-A9452, November 16, 2021. Background:Previous research has shown that age is highly correlated to ECG findings, and machine learning (ML) can be used to predict the age of a patient based on the findings on a 12-lead ECG. We structured a (...) (Circulation)
• 11:42
  Abstract 9454: Knowledge, Attitudes, Beliefs of Acute Coronary Syndrome Among Ethiopian Patients Diagnosed With Acute Coronary Syndrome - Lemlem Demisse Bekele Alemayehu Adamu Addissie Rebecca Gary Addis Ababa Univ, Addis Ababa, Ethiopia Internal medicine, Addis Ababa Univ Public Health, Addis Ababa Univ, Addis Ababa, Ethiopia EMORY UNIVERSITY, Commerce, GA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9454-A9454, November 16, 2021. Background:Acute coronary syndrome (ACS) morbidity and mortality is increasing in low to middle-income countries (LMICs) such as Ethiopia. The shift in resources from managing communicable diseases to chronic (...) (Circulation)
• 11:42
  Abstract 9456: Changes in Cardiovascular Health During Young Adulthood and Subclinical Atherosclerosis in Middle Age - xiaomin ye zhenyu xiong Xiaodong Zhuang Xinxue Liao SUN YAT-SEN UNIVERSITY, Guangzhou, China SUN YAT-SEN UNIVERSITY, China SUN YAT-SEN UNIVERSITY, Guangzhou Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9456-A9456, November 16, 2021. Introduction:The benefits of reaching ideal cardiovascular health (CVH) is well known, but it is unclear whether positive CVH changes form young adulthood to middle age reduces subclinical atherosclerosis (...) (Circulation)
• 10:31
  Abstract 9360: Increasing Mass Transfer Flux of Low-Density Lipoproteins-Cholesterol or Apolipoprotein B at the Endothelium of Atherogenic Sites as a Primary Target of Atherosclerotic Cardiovascular Disease - XING F WANG 3W Consulting comany, Worcester, MA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9360-A9360, November 16, 2021. Major pathological evidences indicate that subendothelial low-density lipoproteins-cholesterol (LDL-c) accumulations at atherogenic sites cause atheroscleroticcardiovascular disease (ACD). As such, current guidelines (...) (Circulation)
• 10:31
  Abstract 9361: The Effect of Immune Checkpoint Inhibitors on the Right Ventricle and Pulmonary Vasculature: Autopsy/Biopsy and Echocardiographic Data - Carolyn G Ahlers Olusola A Orimoloye Jeffrey Annis Kathryn Beckermann Douglas Johnson Javid Moslehi Evan Brittain Vanderbilt Univ Med Cntr, Nashville, TN Nashville, TN Dept of Cardiology, Vanderbilt Univ Med Cntr, Nashville, TN Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9361-A9361, November 16, 2021. Introduction:Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment but can lead to cardiovascular toxicities including myocarditis which can present as left ventricular dysfunction. Little is known (...) (Circulation)
• 10:31
  Abstract 9362: A Quality Improvement Project to Optimize TEE Orders and Reduce Hospitalization Cost at a Large Volume Academic Hospital - Malak Modi Ali Sultan Desiree Dawson Kendall Douglass Kalgi A Modi Louisiana State Univ Health Sciences Cntr Shreveport, Shreveport, LA Louisiana State Univ Shreveport, Shreveport, LA Shreveport, LA LSU HEALTH SCIENCES CENTER, Shreveport, LA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9362-A9362, November 16, 2021. Introduction:Appropriate use criteria (AUC) for indication of transesophageal echocardiography (TEE) were revised in 2011.Aim:To evaluate the appropriateness of TEEs ordered at Ochsner LSU Health Shreveport based on (...) (Circulation)
• 10:31
  Abstract 9363: Ascending Aorta Dilation is Less Frequent in Bicuspid Aortic Valve With Coarctation of Aorta Compared to Isolated Bicuspid Aortic Valve - Anuja Shikhare Moeez Hassan Mary Coffey Ismael Gonzalez Rangel Internal Medicine-Pediatrics, Beaumont Children's Hosp, Royal Oak, MI Pediatrics, Beaumont Children's Hosp, Royal Oak, MI Biostatistics, Beaumont Rsch Institute, Royal Oak, MI Pediatric Cardiology, Beaumont Children's Hosp, Royal Oak, MI Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9363-A9363, November 16, 2021. Introduction:Bicuspid aortic valve (BAV) is known to be associated with aortopathy and aortic valve dysfunction. There is paucity of data in the pediatric population comparing ascending aorta (AA) dilation related to (...) (Circulation)
• 10:31
  Abstract 9364: Caregiver Anxiety Significantly Reduced from Baseline to 24 Months After Surgery: Findings from the Sustaining Quality of Life of the Aged: Heart Transplant or Mechanical Circulatory Support (Sustain-it) Study - Michael Petty Tingqing Wu Adin-cristian Andrei Abigail S Baldridge Anna Warzecha Andrew Kao John Spertus Eileen M Hsich Mary Amanda Dew Duc Thinh Pham Justin Hartupee William Cotts Salpy Pamboukian Francis D Pagani Brent Lampert Maryl R Johnson Margaret A Murray Koji Takeda melana yuzefpolskaya Scott Silvestry James K Kirklin Clyde Yancy Kathleen L Grady M Health Fairview Univ of Minnesota Med Ctr, Richfield, MN Northwestern Univ, Richfield, MN NORTHWESTERN UNIVERSITY, Chicago, IL Chicago, IL Mid America Heart Institute, Kansas City, MO MID AMERICA HEART INST, Kansas City, MO CLEVELAND (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9364-A9364, November 16, 2021. Introduction:We previously reported higher health-related quality of life (HRQOL), lower depression scores, and decreased anxiety in caregivers (CGs) of older (60-80 years) heart failure (HF) patients (PTs) treated (...) (Circulation)
• 10:31
  Abstract 9365: Psip1a is Critical for Vascular Development in Zebrafish - Chang-Ying Chiang Chih-wen Ni Bioengineering, UC MERCED, Merced, CA UC MERCED, Merced, CA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9365-A9365, November 16, 2021. Transcription coactivators function in variety ways which effectively facilitate the process of transcription and play an essential role in gene regulation. Among them, Psip1, the gene codes LEDGF/p75, has been (...) (Circulation)
• 10:31
  Abstract 9367: Predictors of Renal Function Improvement After Left Ventricular Assist Device Implantation in Moderate to Severe Chronic Kidney Disease - Rayhan Saiani Ozan Unlu Hector Sepulveda Alemany Maria Pabon Parag Goyal Irina Sobol Udhay Krishnan Evelyn M Horn Vesh Srivatana Stuart Saal Frank Liu Maria G Karas Weill Cornell Med College, New York Presbyterian Hosp, New York, NY Brigham and Women’s Hosp, New York, NY Weill Cornell Med College, New York Presbyterian Hosp, Pelham, NY Weill Cornell Med College, New York Presbyterian Hosp, New York, TX Weill Cornell Med College, New York Presbyterian Hosp Weill Cornell Med College, New York Presbyterian Hosp, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9367-A9367, November 16, 2021. Introduction:Renal dysfunction remains a relative contraindication to left ventricular assist device (LVAD) implantation due to postoperative morbidity and mortality in advanced stages of chronic kidney disease (CKD). (...) (Circulation)
• 10:31
  Abstract 9368: Concordance of LDL-Cholesterol Levels Between the Friedewald, Martin/Hopkins, and Sampson Equations in Patients With Atherosclerotic Cardiovascular Disease - Aparna Sajja Hsin-Fang Li Kateri Spinelli Salim S Virani Seth S Martin Ty Gluckman JOHN`S HOPKINS, Baltimore, MD CARDS, Providence Heart Institute, Portland, OR MICHAEL E DEBAKEY VA-BAYLOR, Bellaire, TX JOHNS HOPKINS HOSPITAL, Baltimore, MD Providence Heart Institute, Portland, OR Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9368-A9368, November 16, 2021. Introduction:Accurate estimation of low-density lipoprotein cholesterol (LDL-C) is important for cardiovascular risk assessment and guiding cholesterol-lowering therapy. Different methods currently exist to estimate (...) (Circulation)
• 10:31
  Abstract 9369: Nanoparticle-mediated Delivery of TT-10 Promotes Cardiomyocyte Proliferation and Myocardial Repair - Wangping Chen Danielle Pretorius Yang Zhou Jianyi Zhang Dept of Biomedical Engineering, Univ of Alabama at Birmingham, Birmingham, AL Univ of Alabama at Birmingham, Birmingham, AL UNIVERSITY OF ALABAMA AT BIRMINGHAM, Birmingham, AL Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9369-A9369, November 16, 2021. The pharmaceutical product TT-10 increases cardiomyocyte proliferation and survival by upregulating nuclear levels of Yes-associated protein (Yap) and the expression of Yap-targeted genes. When evaluated in a mouse (...) (Circulation)
• 10:31
  Abstract 9370: Myocardial Tissue Characterization of Pediatric Patients With Duchenne Muscular Dystrophy - Sudeep Sunthankar Kristen George-Durrett Kim Crum Larry W Markham Jonathan H Soslow Pediatric Cardiology, Vanderbilt Univ Med Cntr, Nashville, TN Vanderbilt Univ Med Cntr, Nashville, TN Riley Hosp for Children, Indianapolis, IN Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9370-A9370, November 16, 2021. Introduction:Cardiomyopathy (CM) is the leading cause of death in Duchenne muscular dystrophy (DMD). Cardiac magnetic resonance (CMR) parametric mapping sequences, Native T1, T2, and extracellular volume (ECV), can (...) (Circulation)
• 10:31
  Abstract 9372: Association of Past Discrimination With Medication Adherence and Blood Pressure in the HYpertension and VALUEs (HYVALUE) Trial - Rajiv Patel Laura Helmkamp Rebecca Hanratty Suma Vupputuri Irene V Blair Julie Maertens John Steiner Edward P Havranek L. Miriam Dickinson Stacie Daugherty Univ of Colorado Sch of Medicine, Dept of Medicine, Denver, CO Adult and Child Consortium for Outcomes Rsch and Delivery Sciences, Aurora, CO Denver Health and Hosp Authority, Dept of Medicine, Denver, CO Kaiser Permanente Mid-Atlantic States, Mid-Atlantic Permanente Rsch Institute, Rockville, MD Univ of Colorado Boulder, Dept of Psychology and Neuroscience, Boulder, CO Kaiser Permanente Colorado, Institute for Health Rsch, Denver, CO (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9372-A9372, November 16, 2021. Introduction:Racial discrimination has been associated with worse health outcomes, including blood pressure (BP). Using data from the HYVALUE trial, we examined whether past racial discrimination was associated with (...) (Circulation)
• 10:31
  Abstract 9373: Cinnamamide Derivative Reduces Left Ventricular Dysfunction by Modulating Mitochondrial Dynamics in Prediabetic Rats - Natticha Sumneang Thura Tun T Oo Busarin Arunsak Wasana Pratchayasakul Nattayaporn Apaijai Guang Liang Siriporn Chattipakorn Nipon Chattipakorn CERT Cntr, Chiang Mai university, Chiang Mai, Thailand CHIANG MAI UNIVERSITY, Chiang Mai, Thailand Chiang Mai, Thailand CERT Cntr, Chiang Mai, Thailand Wenzhou Med Univ, Wenzhou, China Chiang Mai Univ, Chiang Mai, Thailand Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9373-A9373, November 16, 2021. Introduction:Chronic high-fat diet (HFD) consumption induces prediabetes via increased systemic inflammation by activating myeloid differentiation factor 2 (MD2)/toll-like receptor 4 pathway, resulting in left (...) (Circulation)
• 10:31
  Abstract 9374: The Attenuation of Blood Pressure Lability Assessed by Frequency Analysis of Very Short-Term Continuous Blood Pressure Recording Reflects the Hemodynamic Aggravation in Heart Failure Patients with Reduced Ejection Fraction - Yasunori Suematsu Keita Saku Midori Miyazaki Yuiko Yano Tadaaki Arimura Kanta Fujimi Shin-ichiro Miura Cardiology, Fukuoka Univ Hosp, Fukuoka, Japan Cardiovascular Dynamics, National Cerebral and Cardiovascular Cntr, Osaka, Japan Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9374-A9374, November 16, 2021. Introduction:The lower blood pressure variability (BPV) assessed by 24-hour ambulatory bloop pressure (BP) monitoring predicts cardiac events in heart failure with reduced ejection fraction (HFrEF) patients. However, (...) (Circulation)
• 10:31
  Abstract 9375: Melatonin and Metformin Exert Cardioprotection Against Trastuzumab-induced Cardiotoxicity Through Modulating Cardiac Mitochondrial Dynamics in Rats - Apiwan Arinno Chayodom Maneechote Thawatchai Khuanjing Titikorn Chunchai Nanthip Prathumsap Busarin Arunsak Sasiwan Kerdphoo Krekwit Shinlapawittayatorn Siriporn Chattipakorn Nipon Chattipakorn CHIANG MAI UNIVERSITY, Chiang Mai, Thailand CERT Cntr, Chiang Mai, Thailand Chiang Mai, Thailand Chiang Mai Med Sch, Chiang Mai, Thailand Chiang Mai Univ, Chiang Mai, Thailand Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9375-A9375, November 16, 2021. Introduction:The combination of doxorubicin (Dox) and trastuzumab (Trz) in patients with metastatic human epidermal growth factor receptor 2 (HER2) positive tumors is limited by cardiotoxicity, as manifested by cardiac (...) (Circulation)
• 10:31
  Abstract 9379: Ferroptosis Inhibitor Exerts Greater Efficacy Than Apoptosis and Necroptosis Inhibitors on Improving Cardiac Function via Restoring Cardiac Mitochondrial Function and Attenuating Cardiomyocyte Death in Rats With Iron-Overloaded Cardiomyopathy - Sirinart Kumfu Jirapas Sripetchwandee Natthaphat Siri-angkul Natticha Sumneang Chayodom Maneechote Busarin Arunsak Titikorn Chunchai Siriporn Chattipakorn Nipon Chattipakorn Cardiac Electrophysiology Rsch, Chiang Mai, Thailand CHIANG MAI UNIVERSITY, Chiang Mai, Thailand Chiang Mai Univ, Chiang Mai, Thailand Chiang Mai university, Chiang Mai, Thailand CERT Cntr, Chiang Mai, Thailand Chiang Mai, Thailand Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9379-A9379, November 16, 2021. Introduction:Iron overload cardiomyopathy (IOC) is a common cause of death in iron overload patients. Previous studies reported that iron overload led to cardiac mitochondrial dysfunction and cardiomyocyte death (...) (Circulation)
• 10:31
  Abstract 9380: Rescuing Mitochondrial Fusion/Fission Balance Mitigates Oxidative Stress, Myocardial Injury and Apoptosis in Rats with Doxorubicin-induced Cardiotoxicity - Chayodom Maneechote Thawatchai Khuanjing Benjamin Ongnok Apiwan Arinno Nanthip Prathumsap Titikorn Chunchai Busarin Arunsak Sasiwan Kerdphoo Siriporn Chattipakorn Nipon Chattipakorn CERT Cntr, Chiang Mai, Thailand CHIANG MAI UNIVERSITY, Chiang Mai, Thailand Chiang Mai Univ Chiang Mai, Thailand Chiang Mai Univ, Chiang Mai, Thailand Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9380-A9380, November 16, 2021. Introduction:Doxorubicin (DOX) has been an extensively used chemotherapeutic drug in handling a wide range of cancers. Cardiotoxicity induced by DOX is a serious adverse effect of oncologic therapy. Although (...) (Circulation)
• 10:31
  Abstract 9383: Dapagliflozin, an Sglt2 Inhibitor, Reduces Expression of Myd88, Nlrp3 and Nf-kb During Exposure to Doxorubicin and Trastuzumab in Cellular Models - Nicola Maurea Andrea Paccone Martina Iovine Simona Buccolo Francesca Cerrone Vincenzo Quagliariello National Cancer Institute Pascale, Naples, Italy IRCCS Fondazione G.Pascale, Naples, Italy Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9383-A9383, November 16, 2021. Introduction:The cumulative incidence of cardiac events in women treated with anthracycline and trastuzumab at 1 year after the diagnosis of breast cancer was 16.4%, at 2 years 23.8 %, and at 3 years 28.2%. Sodium (...) (Circulation)
• 10:31
  Abstract 9384: Evolocumab, a Proprotein Convertase Subtilisin-Kexin Type 9 Inhibitor, Reduces Doxorubicin, Trastuzumab and Nivolumab Induced Cardiotoxicity Through Mtorc1 and Myd88 Related Pathways - Nicola Maurea Martina Iovine Simona Buccolo Andrea Paccone Francesca Cerrone Vincenzo Quagliariello National Cancer Institute Pascale, Naples, Italy Pontecagnano, Italy IRCCS Fondazione G.Pascale, Naples, Italy Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9384-A9384, November 16, 2021. Introduction:The PCSK9 inhibitor evolocumab reduced low-density lipoprotein cholesterol and cardiovascular events in the FOURIER randomized clinical trial. Recent studies indicates the crucial involvement of PCSK9 in (...) (Circulation)
• 10:31
  Abstract 9385: Sacubitril-Valsartan (lcz-696) Improves Ejection Fraction and Longitudinal Strain in Mice Exposed to Doxorubicin Through Nlrp3 Inflammasome, Myd88 Myddosome and Chemokines - Nicola Maurea Andrea Paccone Simona Buccolo Martina Iovine Domenica Rea Antonio Barbieri Francesca Cerrone Vincenzo Quagliariello National Cancer Institute Pascale, Naples, Italy Pontecagnano, Italy IRCCS Fondazione G.Pascale, Naples, Italy Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9385-A9385, November 16, 2021. Introduction:Doxorubicin-mediated adverse cardiovascular events are among the leading causes of morbidity and mortality in breast cancer patients. Sacubitril-valsartan (LCZ 696) is a combination drug, made up of (...) (Circulation)
• 10:31
  Abstract 9386: Marfan Syndrome Mouse Model Mg?Lpn Presents Alterations in Glomerular Architecture and Increased Renal Vascular Resistance. Losartan Treatment Attenuates These Phenotypes - Rodrigo Barbosa Souza Dieter P. Reinhardt Ivan H Koh Lygia d Pereira Universidade de Sao Paulo, Sao Paulo, Brazil Dept of Anatomy and Cell Biology and Faculty of Dentistry, McGill Univ, Montreal, Canada Dept of Surgery, Federal Univ of São Paulo, Sao Paulo, Brazil Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9386-A9386, November 16, 2021. Introduction:Previously, we have shown that mg?lpnmurine Marfan syndrome (MFS) model with a fibrillin-1 disruption presents increased Metalloproteinase-9 (MMP-9) expression in the cilliary body in eye. MMP-9 has been (...) (Circulation)
• 10:31
  Abstract 9388: The ALPACA Study, an EHR Based Analysis of the Association of Elevated Alkaline Phosphatase With Cardiovascular Events - Philip Ambery Fe Van-den-Broek Irena Brookes-Smith Late-Stage Development CVRM, Astrazeneca, Molndal, Sweden Imperial College, Univ of London, London, United Kingdom Real World Strategy & Capabilities, AstraZeneca, Cambridge, United Kingdom Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9388-A9388, November 16, 2021. Alkaline phosphatase (ALP) has a key role in vascular calcification, a process implicated in cardiovascular (CV) diseases. Previous studies suggest elevated ALP is associated with increased risk of CV events, and that (...) (Circulation)
• 10:31
  Abstract 9389: Apache Clinical Text Analysis Knowledge Extraction System (ctakes) Identifies One Out of Five Suspicious Symptoms of Acute Coronary Syndrome from Emergency Department Nursing Triage Notes - Stephanie O Frisch Denis Newman-Griffis Zhendong Wang Jessica K Zegre-hemsey Clifton W CALLAWAY Harry Hochheiser Holli A Devon Suzanne Bakken Ervin Sejdic Univ of Pittsburgh, Pittsburgh, PA Biomedical Informatics, Univ of Pittsburgh, Pittsburgh, PA UNC CHAPEL HILL, Chapel Hill, NC UNIVERSITY PITTSBURGH, Pittsburgh, PA UCLA, Los Angeles, CA Columbia Univ, New York, NY Pittsburgh, PA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9389-A9389, November 16, 2021. Introduction:Acute coronary syndrome is a time sensitive condition requiring rapid identification, but nurses only identify 40%-50% of high-risk patients at emergency department (ED) triage. Symptoms are the driving (...) (Circulation)
• 10:31
  Abstract 9390: Mechanical Circulatory Support and Outcomes in Women versus Men - Nicole Pristera Zachary Il'Giovine Weili Zheng Beka Bakhtadze Leslie Cho Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH CLEVELAND CLINIC FOUNDATION, Cleveland, OH Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9390-A9390, November 16, 2021. Introduction:There has been a substantial increase in the use of temporary mechanical circulatory support (MCS) in cardiac intensive care, particularly driven by Impella and veno-arterial extracorporeal membrane (...) (Circulation)
• 10:31
  Abstract 9392: Cardiovascular, Metabolic and Safety Outcomes With Semaglutide by Age: A Post Hoc Analysis of SUSTAIN 6 and PIONEER 6 - Mark Petrie Stephen Bain Soren Tetens Hoff Nicklas Johansen Søren Rasmussen Tina Vilsboell Mansoor Husain Univ of Glasgow, Glasgow, United Kingdom Swansea Univ Med Sch, Swansea, United Kingdom Novo Nordisk A/S, Søborg, Denmark Steno Diabetes Cntr Copenhagen, Gentofte Hosp, Univ of Copenhagen, Hellerup, Denmark Ted Rogers Cntr for Heart Rsch, Toronto, Canada Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9392-A9392, November 16, 2021. Introduction:For older patients with type 2 diabetes, treatments that minimize the risk of hypoglycemia and provide benefits in terms of comorbidities, while optimizing glycemic control, are particularly important. (...) (Circulation)
• 10:31
  Abstract 9393: A Genetic Risk Score to Predict Peripheral Artery Disease and Acute Limb Ischemia in Patients With Cardiometabolic Disease - Siddharth M Patel Nicholas A Marston Giorgio E Melloni Frederick K Kamanu Carolina Roselli Elliott M Antman Deepak L Bhatt Eugene Braunwald Christopher P Cannon Michelle L Odonoghue Robert P Giugliano Ofri Mosenzon Benjamin M Scirica Steven A Lubitz Patrick T Ellinor Marc P Bonaca Marc S Sabatine Christian T Ruff Brigham and Women's Hosp, TIMI Study Group, Boston, MA Broad Institute, Boston, MA Brigham and Women's Hosp, Boston, MA Brigham and Womens Hosp, Boston, MA Hadassah Hebrew Univ Hosp, Jerusalem, Israel Massachusetts General Hosp, Boston, MA CPC Clinical Rsch, Aurora, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9393-A9393, November 16, 2021. Introduction:GWAS have identified SNPs associated with an increased risk of peripheral artery disease (PAD). We sought to compare the performance of a genetic risk score (GRS) comprised of these SNPs with established (...) (Circulation)
• 10:31
  Abstract 9394: Establishing Validity of a Midlife Black Women's Wellness Program - Holly J Jones Melinda Butsch Kovacic Tamilyn Bakas College of Nursing, Univ of Cincinnati, Cincinnati, OH College of Allied Health Sciences, Univ of Cincinnati, Cincinnati, OH Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9394-A9394, November 16, 2021. Introduction:Expert ratings and qualitative feedback are essential for establishing validity of materials developed for interventions. Validation of intervention content should be established prior to initiation of (...) (Circulation)
• 10:31
  Abstract 9396: Evaluation of the ABC Pathway for Comprehensive Management of Atrial Fibrillation in 20,933 Patients from the ENGAGE AF-TIMI 48 Trial - Siddharth M Patel Sabina A Murphy Elliott M Antman Eugene Braunwald Gregory Y Lip Robert P Giugliano Christian T Ruff Brigham and Women's Hosp, TIMI Study Group, Boston, MA Univ of Liverpool, Liverpool Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9396-A9396, November 16, 2021. Introduction:Pts with atrial fibrillation (AF) are at high risk of morbidity and mortality beyond ischemic stroke. The ABC (Atrial Fibrillation Better Care) comprehensive care approach was devised to improve overall (...) (Circulation)
• 10:31
  Abstract 9397: Sonothrombolysis Improves Cardiac Segmental Contractility, Myocardial Perfusion and Baroreflex Gain in Patients With ST-segment Elevation Myocardial Infarction (stemi) in Long-Term Follow-Up - Luciene F Azevedo Bruno Carter C Borges Edgar Toschi-Dias Larissa Ferreira-santos Raphaela V Groehs Jeane M Tsutsui Amisa Guimaraes marco C oliveira Paola E smanio Thomas R Porter Wilson Mathias Echocardiography Dept, Heart Institute, Clinical Hosp, Med Sch of Univ of Sao Paulo, Sao Paulo, Brazil Heart Institute, Clinical Hosp, Med Sch of Univ of Sao Paulo, Sao Paulo, Brazil Fleury Medicine and Health, São Paulo, Brazil Fleury Medicine and Health, Sao Paulo, Brazil Univ Nebraska Med Ctr, Omaha, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9397-A9397, November 16, 2021. Sonothrombolysis (Sono) has improved microvascular obstruction, global contractility and infarct area after STEMI.Objective:To evaluate the long-term effect of Sono and its physiologic mechanisms in a subgroup of 51 (...) (Circulation)
• 10:31
  Abstract 9398: Dantrolene Prevents Doxorubicin-Induced Cardiac Ryanodine Receptor Dyssynchrony - Arjun K Aggarwal Mohammed Ali Azam Praloy Chakraborty Stéphane Massé Ahmed Niri Patrick F Lai Sheila Riazi Filio Billia Keith Dadson Kumaraswamy Nanthakumar Cardiology, Univ Health Network, Toronto, Canada Univ Health Network, Toronto, Canada Div of Cardiology, Univ Health Network, Toronto, Canada Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9398-A9398, November 16, 2021. Background:Ryanodine receptor 2 (RyR2) is important for cardiac calcium release from the sarcoplasmic reticulum. RyR2 activation triggers a spatio-temporally regulated calcium spark. Synchronous activation of RyR2 (...) (Circulation)
• 10:31
  Abstract 9399: A Targeted Proteomic Approach Identifies Novel Biomarkers Associated With Risk of Myocardial Infarction in Post-Menopausal Women - Siddharth M Patel David A Morrow Minao Tang Frederick K Kamanu KyungAh Im Marc S Sabatine Michelle L Odonoghue Brigham and Women's Hosp, TIMI Study Group, Boston, MA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9399-A9399, November 16, 2021. Introduction:There may be unique pathways that contribute to heart disease in women. We used proteomics to evaluate the association between a panel of biomarkers and risk of incident MI in post-menopausal women and (...) (Circulation)
• 10:31
  Abstract 9137: Isolated Liver Perfusion and Electron Microscopy Reveal Defect in Vldl Lipidation Associated With Inactivation of Tm6sf2 - Fei Luo Justin A Fletcher Eriks Smagris Shawn C Burgess Jonathan C Cohen Helen H Hobbs Second Xiangya Hosp of Central South Univ and Univ of Texas Southwestern Med Cntr Cntr for Human Nutrition, Univ of Texas Southwestern Med Cntr, Dallas, TX Univ of Texas Southwestern Med Cntr, Dallas, TX Dept of Molecular Genetics, Univ of Texas Southwestern Med Cntr, Dallas, TX Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9137-A9137, November 16, 2021. Background:A missense variant (E167K) in Transmembrane 6 Superfamily Member 2 (TM6SF2) is associated with lower plasma lipid levels and protection from coronary artery disease. Inactivation ofTm6sf2in mice results in (...) (Circulation)
• 10:31
  Abstract 9138: Thioredoxin-Interacting Protein is a Regulator of Redox Homeostasis in Diabetic Cardiomyopathy - Jun Yoshioka Molecular Cellular & Biomedical Sciences, City Univ of New York Sch of Medicine, NEW YORK, NY Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9138-A9138, November 16, 2021. Introduction:Although the precise pathogenesis of diabetic cardiac damage remains unclear, potential mechanisms include increased oxidative stress. Thioredoxin-interacting protein (Txnip) is a binding partner and an (...) (Circulation)
• 10:31
  Abstract 9139: Two Decade Trends in Cardiovascular Health Among Adults With Cardiovascular Disease in the United States Using a Revised American Heart Association Life's Simple 7 Framework - Yumin Gao Nino Isakadze Eamon Duffy Qicong Sheng Jie Ding Zane MacFarlane Scott T McClure Yingying Sang Elizabeth Selvin Kuni Matsushita Seth S Martin JOHNS HOPKINS SCHOOL OF MEDICINE, Baltimore, MD SHENANDOAH UNIVERSITY, Winchester, VA JOHNS HOPKINS UNIVERSITY, Baltimore, MD JOHNS HOPKINS HOSPITAL, Baltimore, MD Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9139-A9139, November 16, 2021. Introduction:The American Heart Association Life’s Simple 7 (LS7) framework is used to promote cardiovascular health. Trends in cardiovascular health of US adults with a history of cardiovascular disease (CVD) are not (...) (Circulation)
• 10:31
  Abstract 9140: Validity of Coronary Angiography-Based Physiology in Clinical Practice - Luciano de Moura Santos wenderval B carvalho junior Marcelo H Ribeiro Maria Antonieta A Lopes Julia T Fukushima Alexandre A Abizaid Carlos M Campos Interventional Cardiology, Hosp Santa Lucia, Brasilia, Brazil Interventional Cardiology, Heart Institute, Univ of Sao Paulo Med Sch, Sao Paulo, Brazil Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9140-A9140, November 16, 2021. Introduction:The invasive physiological assessment of the severity of coronary obstruction is performed by hyperemic (FFR) and non-hyperemic (iFR) indices. However, the need to insert an intracoronary pressure (...) (Circulation)
• 10:31
  Abstract 9141: Cardiac Injury and Mortality Among Covid-19 Patients in a Predominantly Black Community of East Flatbush Brooklyn - Emmanuel C Adomfeh Jonathan Francois Harshith Priyan Anoop V Puskoor Clara Wilson Brandon DaSilva Jean Adomfeh Dept of Medicine, SUNY Downstate, Brooklyn, NY Havard Med Sch, Boston, MA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9141-A9141, November 16, 2021. Introduction:Black/African-American (AA) populations have been previously shown to have increased disease burden of COVID-19 and related deaths. However, not many studies have examined cardiovascular comorbidities and (...) (Circulation)
• 10:31
  Abstract 9142: Predictors of New-Onset Atrial Fibrillation in the Setting of Acute Coronary Syndromes: A Nationwide Multi-Center Study - Jia Yi Anna Ne Austin Chin Chwan Ng Karice HYUN Farzaneh Boroumand Clara K Chow Ben B Freedman David Brieger Cardiology, The Univ of Sydney, Concord Hosp, Westmead Hosp, Concord, Australia Cardiology, Concord Hosp, Australia Cardiology, Sch of Health Sciences, Faculty of Medicine and Health, Univ of Sydney, Concord, Australia ANZAC research Institute, Univ of Sydney, Australia UNIVERSITY OF SYDNEY, Westmead, Australia HEART RESEARCH INSTITUTE, THE UNIVERSITY OF SYDNEY, Sydney, Australia Cardiology, Concord Hosp, Sydney, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9142-A9142, November 16, 2021. Introduction:New-onset atrial fibrillation (AF) following acute myocardial infarction (AMI) is associated with adverse outcomes, though studies exploring the interaction between AF and the full spectrum of acute (...) (Circulation)
• 10:31
  Abstract 9146: Efficacy and Safety of Esaxerenone in Hypertensive Patients with Heart Failure with Reduced Ejection Fraction - Ryohei Ono Togo Iwahana Hirotoshi Kato Sho Okada Yoshio Kobayashi Dept of Cardiovascular Medicine, Chiba Univ Graduate Sch of Medicine, Chiba, Japan Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9146-A9146, November 16, 2021. Introduction:Esaxerenone, a mineralocorticoid receptor blocker (MRB), is a new antihypertensive agent. However, esaxerenone-related data with respect to hypertension with heart failure are (...) (Circulation)
• 10:31
  Abstract 9147: Reduced Delta-6-Desaturase Activity May Be Associated With Major Adverse Cardiac Events During 2 Years Follow Up in Elderly Patients With a Recent Myocardial Infarction - Dennis W Nilsen Peder L Myhre Are Annesoenn Kalstad Erik Berg Schmidt Harald Arnesen Ingebjorg Seljeflot STAVANGER UNIVERSITY HOSPITAL, Stavanger, Norway Oslo, Norway Oslo Univ Hosp, Ullevaal, Oslo, Norway OSLO UNIVERSITY HOSPITAL ULLEVAL, Oslo, Norway OSLO UNIVERSITY HOSPITAL ULLEVAAL, Oslo, Norway Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9147-A9147, November 16, 2021. Background:Low levels of dihomo-gamma linolenic acid (DGLA) have been related to a bad outcome in patients with acute coronary syndromes. Reduced levels of DGLA may result from reduced conversion of its precursor (...) (Circulation)
• 10:31
  Abstract 9149: The Novel Wnt-Pathway Inhibitor Podocan is Not Associated with All-Cause Mortality or Cardiovascular Outcome in Patients Admitted with Suspected Acute Coronary Syndrome - Thomas Andersen Dennis W Nilsen Heidi Grundt Harry Staines Thor Ueland Pal Aukrust Frederic P Kontny Dpt of Anaesthesiology, Stavanger Univ Hosp, Stavanger, Norway Stavanger Univ Hosp, Stavanger, Norway Sigma Statistical Services, York, United Kingdom Oslo Univ Hosp, Oslo, Norway Dpt of internal medicine, section for clinical immunology and infectious disease, Oslo Univ Hosp, Oslo, Norway Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9149-A9149, November 16, 2021. Introduction:Podocan, a novel extracellular matrix glycoprotein, is a smooth muscle cell regulator and abundantly expressed in human atheroma. The association of Podocan with cardiovascular outcome remains unclear. The (...) (Circulation)
• 10:31
  Abstract 9150: Actigraphy-Derived Sleep Health Metrics and Biomarkers of Cardiovascular Disease Risk in Black/African American Smokers - Elissa K Hoopes aditi satti Benjamin Brewer Rachel Blair Adam Davey Michael A Grandner William B Farquhar Freda Patterson Univ of Delaware, Newark, DE Thoracic Medicine and Surgery, Lewis Katz Sch of Medicine at Temple Univ Hosp, Philadelphia, PA Newark, DE UNIVERSITY OF ARIZONA, Tucson, AZ UNIVERSITY OF DELAWARE, Newark, DE Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9150-A9150, November 16, 2021. Introduction:Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in Black/African American (BAA) adults, and to a greater extent in BAAs who smoke cigarettes. Sleep is an emergent predictor (...) (Circulation)
• 10:31
  Abstract 9151: Impact of Adult Congenital Cardiologists on the Care of Adults With Congenital Heart Disease - Katherine B Salciccioli Hechuan Hou Mark D Norris Timothy B Cotts Peter Sassalos Ming-sing Si Michael P Thompson Internal Medicine, Univ of Michigan, Ann Arbor, MI Univ of Michigan, Ann Arbor, MI Cardiac Surgery, Univ of Michigan, Ann Arbor, MI Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9151-A9151, November 16, 2021. Introduction:The adult congenital heart disease (ACHD) population has unique medical needs requiring specialized care. We evaluated the association between ACHD physician visits and guideline-adherent care in a cohort (...) (Circulation)
• 10:31
  Abstract 9153: Predictive and Protective Factors of Early, Late, and Very Late Stent Thrombosis in Acute Coronary Syndrome Patients Undergoing Coronary Stent Implantation: Findings from the Atlas Acs 2-timi 51 Trial - Gerald Chi Fahad Alkhalfan Jane J Lee Sahar Memar Montazerin Clara Fitzgerald Serge Korjian Wally Omar Elliot Barnathan Alexei Plotnikov Eugene Braunwald C. Michael Gibson BETH ISRAEL DEACONESS MED CTR, Boston, MA Baim Institute for Clinical Rsch, Boston, MA Johnson & Johnson Pharmaceutical Rschand Development, Raritan, NJ Brigham and Women's Hosp, Boston, MA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9153-A9153, November 16, 2021. Introduction:Stent thrombosis (ST) is an uncommon but serious complication of stent implantation. The aim of this analysis was to explore predictive and protective factors of early, late, and very late ST.Methods:This (...) (Circulation)
• 10:31
  Abstract 9154: Sex Differences in Mortality from Covid-19 Pandemic: Are Men Vulnerable and Women Protected. Why? - Khalida Soomro Muhammad Ali Soomro Cardiology, Dow Univ of Health Sciences, Karachi, Pakistan Pathology, Bilawal Med College, Liaquat Univ of Med and Health Sciences, Jamshoro, Pakistan Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9154-A9154, November 16, 2021. The epidemiological studies shows that compared to women, men infected with the novel COVID-19 have more severe and threatening disease and have a higher mortality globally. The population which is under real panic (...) (Circulation)
• 10:31
  Abstract 9156: P-Wave Axis is an Independent Predictor of Mortality in Type II Diabetes Mellitus: The Diabetes Heart Study - Pooja D Patil Matthew J Singleton Georgia Saylor Donald Bowden Joseph Yeboah WAKE FOREST SCHOOL OF MEDICINE, Winston Salem, NC WAKE FOREST SCHOOL OF MEDICINE, Winston-Salem, NC Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9156-A9156, November 16, 2021. Introduction:Abnormal P-wave axis (PWA) has been associated with an increased risk of all-cause and cardiovascular mortality in various populations. However, the correlation of this prognostic indicator with mortality (...) (Circulation)
• 10:31
  Abstract 9159: Mindfulness Training, Cognitive Function and Interoceptive Awareness in Heart Failure Outpatients: Preliminary Findings - Elena Salmoirago-blotcher Kristen Walaska Dyuti Trivedi Shira Dunsiger Daniel Levine Christopher Breault Jia-Rong Wu Ronald Cohen MIRIAM HOSPITAL, BROWN MED SCHOOL, Providence, RI Brown Univ, Providence, RI Brown Univ, E Providence, RI Univ of Kentucky, KY Univ of Florida, FL Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9159-A9159, November 16, 2021. Introduction:Cognitive impairment affects up to 2/3 of patients with heart failure (HF) and is an important barrier to HF self-care. Adequate interoceptive awareness (the ability to sense and interpret signals from (...) (Circulation)
• 10:31
  Abstract 9161: Referral Patterns Do Not Contribute to Racial Differences in Catheter Ablation for Atrial Fibrillation - Jessica E Marot Lindsay R Pool Yoshihiro Tanaka Celeste Witting Sadiya S Khan Rod S Passman Dept of Medicine, Northwestern Univ Feinberg Sch of Medicine, Chicago, IL Dept of Preventive Medicine, Northwestern Univ Feinberg Sch of Medicine, Chicago, IL Cntr for Arrhythmia Rsch, Northwestern Univ Feinberg Sch of Medicine, Chicago, IL Northwestern Univ Feinberg Sch of Medicine, Chicago, IL Div of Cardiology, Northwestern Univ Feinberg Sch of Medicine, Chicago, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9161-A9161, November 16, 2021. Introduction:Non-Hispanic Black (NHB) adults with atrial fibrillation (AF) are less likely to undergo catheter ablation (AFCA) compared with non-Hispanic White (NHW) adults even among those with heart failure and even (...) (Circulation)
• 10:31
  Abstract 9162: Increased Ratio of B2/B1-like Lymphocytes in the Perivascular Adipose Tissue Could Contribute to Plaque Destabilization in Human Coronary Arteries: Preliminary Results - Daniela S Farias-itao Carlos Augusto Pasqualucci Renato A Andrade Luiz Fernando F da Silva Maristella Y Estevam Alexandre B Campo Claudia K Suemoto Pathology, Univ of Sao Paulo Med Sch, Sao Paulo, Brazil Univ of Sao Paulo Med Sch, São Paulo, Brazil Control and Automation Engineering, Federal Institute of Education, Science and Technology of Sao Paulo, São Paulo, Brazil Discipline of Geriatrics, Univ of Sao Paulo Med Sch, Sao Paulo, Brazil Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9162-A9162, November 16, 2021. Introduction:B-lymphocyte density in the pericoronary adipose tissue (PvAT) was correlated with plaque size in human coronary arteries. However, the subtypes of B cells in the PvAT and atherosclerotic plaque (...) (Circulation)
• 10:31
  Abstract 9163: Demographic Differences in Hypertension and Its Treatment in Malawi - Saate S Shakil Alison J Price Gregory A Roth Amelia Crampin Owen Nkoka Chifundo Kanjala Univ of Washington, Seattle, WA Oxford UNIVERSITY WASHINGTON, Seattle, WA Malawi and Epidemiology and Intervention Rsch Unit (MEIRU), London Sch of Hygiene and Tropical Medicine Institute of Health and Wellbeing, Univ of Glasgow, Glasgow, United Kingdom Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9163-A9163, November 16, 2021. Background:Hypertension (HTN), a strong risk factor for cardiovascular disease (CVD), is highly prevalent in Sub-Saharan Africa. Health system interventions targeting demographic determinants of diagnosis and treatment (...) (Circulation)
• 10:31
  Abstract 9165: Relationship Between the Cholesterol and Triglyceride Content of Lipoprotein Subclasses and Carotid Imtima-Media Thickness: Results from the Kyushu and Okinawa Population Study - Hiroaki Ikezaki Norihiro Furusyo Masumi Ai Mitsuyo Okazaki JUN HAYASHI Eliana J Polisecki General Internal Medicine, KYUSHU UNIVERSITY HOSPITAL, Fukuoka, Japan Kyushu Univ, Fukuoka, Japan TOKYO MEDICAL AND DENTAL UNIVERSITY, Tokyo Tokyo Med and Dental Univ, Tokyo, Japan TUFTS UNIVERSITY, Boston, MA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9165-A9165, November 16, 2021. Introduction:The association between 20 lipoprotein cholesterol and triglycerides subclasses and carotid intimal medial thickness (cIMT) progression has not been evaluated fully.Objective:Our goal was to assess which (...) (Circulation)
• 10:31
  Abstract 9166: Serum Level of Membrane Type 1-Matrix Metalloproteinase Inversely Corelates With Right Ventricular Systolic Pressure and Mean Pulmonary Artery Pressure in Pulmonary Hypertension - Koichi Sugimoto Tomofumi Misaka Akiomi Yoshihisa Kazuhiko Nakazato Takafumi Ishida Yasuchika Takeishi Dept of Cardiovascular Medicine, Fukushina Med Univ, Fukushima, Japan Dept of Cardiovascular Medicine, Fukushima Med Univ, Fukushima, Japan Fukushina Med Univ, Fukushima, Japan Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9166-A9166, November 16, 2021. Introduction:Pulmonary hypertension (PH) is defined as mean pulmonary arterial pressure (mean PAP) ? 25 mmHg and characterized by pulmonary vascular remodeling. Although right heart catheterization is essential for a (...) (Circulation)
• 10:31
  Abstract 9167: Relationship Between Dietary Vitamin D Intake, Obesity, and Twenty Lipoprotein Subclasses: Results from the Kyushu and Okinawa Population Study - Hiroaki Ikezaki Ryoko Nakashima Norihiro Furusyo Masumi Ai Mitsuyo Okazaki JUN HAYASHI Eliana J Polisecki General Internal Medicine, KYUSHU UNIVERSITY HOSPITAL, Fukuoka, Japan Kyushu Univ, Fukuoka, Japan TOKYO MEDICAL AND DENTAL UNIVERSITY, Tokyo Tokyo Med and Dental Univ, Tokyo, Japan TUFTS UNIVERSITY, Boston, MA Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9167-A9167, November 16, 2021. Introduction:The correlation between serum vitamin D deficiency, obesity, and various diseases has been reported, however, there were few investigations on the role of dietary vitamin D intake on obesity and (...) (Circulation)
• 10:31
  Abstract 9169: A Non-Invasive Virtual Heart Approach Predicts Reentrant Ventricular Arrythmia (VA) Circuits in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC): A Proof-of-Concept Study - Yingnan Zhang Adityo Prakosa Pallavi Pandey Stefan L Zimmerman Harikrishna Tandri Cynthia A James Crystal Tichnell Brittney Murray Hugh Calkins Natalia Trayanova Dept of Biomedical Engineering, Johns Hopkins Univ, Baltimore, MD Alliance for Cardiovascular Diagnostic and Treatment Innovation, Johns Hopkins Univ, Baltimore, MD Dept of Radiological Sciences, Johns Hopkins Hosp, Baltimore, MD Dept of Medicine, Johns Hopkins Hosp, Baltimore, MD Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9169-A9169, November 16, 2021. Introduction:ARVC is a leading inherited cause of VA in young adults. Progressive and extensive structural and electrical remodeling in the right ventricle (RV) serves as a complex substrate for reentrant VA circuits (...) (Circulation)
• 10:31
  Abstract 9170: Medication Reconciliation: Much Remains to Be Done - Anas Bizanti Ahmad Al-abdouh Sadam Haddadin Mohammed Mohammed Mina Michael Roshniben Patel Gina Patel Samir Ahmed Sapna Kuehl Saint Agnes hospital, Baltimore, MD Saint Agnes Hosp, Baltimore, MD Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9170-A9170, November 16, 2021. Introduction:Medication reconciliation had been a persistently national patient safety issue. Despite several efforts, the rate of error is still significantly high, and the measures that had been taken to improve this (...) (Circulation)
• 10:31
  Abstract 9172: Feasibility and Efficacy of Targeted Cardiac NF-kB Inhibition in Experimental Diastolic Dysfunction Using Drug-Delivery Technology: A Proof-of-Concept Study - Alejandro R Chade Alfonso Eirin Gene L Bidwell UNIV OF MISSISSIPPI MED CTR, Jackson, MS MAYO CLINIC, Rochester, MN Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9172-A9172, November 16, 2021. Introduction:Elastin-like polypeptides (ELP) are novel drug delivery vectors that can be fused to therapeutic agents and cell penetrating peptides (CPPs), slowing their plasma clearance and increasing uptake by target (...) (Circulation)
• 10:31
  Abstract 9173: Perioperative Change in Left Ventricular Systolic Function Predicts Long-Term Mortality After CABG - Michael Downey Matthew Hooks Amy Gravely Niyada Naksuk Melissa Buelt-Gebhardt Selma Carlson Venkatakrishna N Tholakanahalli Selcuk Adabag Internal Medicine and Pediatrics, Univ of Minnesota, Minneapolis, MN Univ of Minnesota, Minneapolis, MN Minneapolis VA Med Cntr, Minneapolis, MN Univ of Nebraska Med Cntr, Omaha, NE Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9173-A9173, November 16, 2021. Introduction:Nearly 1/3rdof patients undergoing CABG have concurrent left ventricular systolic dysfunction (LVEF5% increase), unchanged, and worsened (>5% decrease).Results:Of the 549 patients (mean age 61.4±9.6 years, (...) (Circulation)
• 10:31
  Abstract 9174: Integration of Nonlinear Analysis and Artificial Intelligence for Human Ipsc-based Drug Cardiotoxicity Classification - Zhen Ma Andrew Kowalczewski Biomedical & Chemical Engineering, SYRACUSE UNIVERSITY, Syracuse, NY Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9174-A9174, November 16, 2021. Introduction:Recent advances in human induced pluripotent stem cell (hiPSC) technology have granted novel tools to evaluate drug-induced cardiotoxicity on human cardiomyocytes. The contractile signals recorded from (...) (Circulation)
• 10:31
  Abstract 9175: Clinical Significance of Resting Heart Rate on Exercise Capacity and Prognosis: Comparison Among Heart Failure Patients with Reduced, Preserved and Mid-Range Ejection Fraction - Takamasa Sato Akiomi Yoshihisa Takafumi Ishida Yasuchika Takeishi FUKUSHIMA MEDICAL UNIVERSITY, Fukushima, Japan FUKUSHIMA MEDICAL UNIV, Fukushima FUKUSHIMA MEDICAL UNIVERSITY, Fukushima Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9175-A9175, November 16, 2021. Introduction:Resting heart rate (rHR) has a big influence on clinical outcomes and exercise capacity in patients with chronic heart failure (CHF). However, the association of rHR with exercise capacity and prognosis (...) (Circulation)
• 10:31
  Abstract 9176: Quarterly versus Annual ECG Screening for Atrial Fibrillation in Older Chinese (AF-CATCH): A Prospective, Randomised, Controlled Trial - Wei Zhang Yi Chen Jiguang Wang The Shanghai Institute of Hypertension, Shanghai, China The Shanghai Institute of Hypertension, Shanghai Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9176-A9176, November 16, 2021. Introduction:Screening for atrial fibrillation before symptoms manifested and subsequent initiation of oral anticoagulants (OACs), could prevent stroke and death. The most cost-effective strategy to screen atrial (...) (Circulation)
• 10:31
  Abstract 9177: Prognostic Value of Chronic Kidney Disease and Cardiac Sympathetic Dysfunction Assessed by 123I-metaiodobenzylguanidine Scintigraphy for Lethal Arrhythmic Events in Chronic Heart Failure - Kazuaki Amami Shinya Yamada Takashi Kaneshiro Akiomi Yoshihisa Naoko Hijioka Minoru Nodera Yasuchika Takeishi CARDIOVASCULAR MEDICINE, FUKUSHIMA MEDICAL UNIV, Fukushima, Japan FUKUSHIMA MEDICAL UNIV, Fukushima, Japan Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9177-A9177, November 16, 2021. Introduction:Clinical implication of chronic kidney disease (CKD) and cardiac sympathetic nerve activity (CSNA) for lethal arrhythmic events has not been fully elucidated in patients with chronic heart failure (...) (Circulation)
• 10:31
  Abstract 9185: Diagnostic Utility of R-R Interval Variations Under Deep Breathing Load in Patients With Cardiac Amyloidosis - Yasuhiro Nagayoshi Hiroaki Kawano Naritsugu Sakaino Taiki Nishihara Kei Morikawa Shinsuke Hanatani Hiroki Usuku Kenichi Tsujita Amakusa Med Cntr, Amakusa, Japan KUMAMOTO UNIVERSITY, Kumamoto, Japan Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9185-A9185, November 16, 2021. Introduction:Autonomic disorder is one of important characteristics of cardiac amyloidosis. However, the prevalence of autonomic disorder in wild-type transthyretin amyloidosis (ATTRwt) remains to be elucidated. (...) (Circulation)
• 10:31
  Abstract 9186: Maslinic Acid Alleviates Atherosclerosis by Suppressing Mitochondrial ROS-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1/Nrf2 Pathway - Li Zhuqing Lu Chengzhi Sch of medicine, Nankai Univ, Tianjin, China Dept of Cardiology, Tianjin First Central Hosp, Tianjin, China Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9186-A9186, November 16, 2021. Introduction:Maslinic acid (MA), a pentacyclic triterpenoid primarily found in food plants, has exhibited multiple inhibitory effects on proatherogenic factors, such as obesity, dyslipidemia, and inflammation. However, (...) (Circulation)
• 10:31
  Abstract 9187: Risk Factors for the Onset of Coronary Artery Calcium in Younger versus Older Persons - Alexander C Razavi Norrina B Allen Omar Dzaye Erin Michos Matthew J Budoff Joao A Lima James M Shikany Kiang Liu Wendy Post Roger S Blumenthal Michael J Blaha Jeffrey Carr Seamus P Whelton Medicine, Emory Sch of Medicine, Atlanta, GA NORTHWESTERN UNIVERSITY, Chicago, IL JOHNS HOPKINS UNIVERSITY, Baltimore, MD Johns Hopkins Sch of Medicine, Baltimore, MD LOS ANGELES BIOMEDICAL RESEARC, Torrance, CA Medicine, Cardiology, Johns Hopkins Univ Sch of Medicine, Baltimore, MD UNIVERSITY OF ALABAMA AT BIRMINGHAM, Birmingham, AL JOHNS HOPKINS HOSPITAL, Baltimore, MD Vanderbilt, Nashville, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9187-A9187, November 16, 2021. Introduction:Modifiable traditional atherosclerotic cardiovascular disease (ASCVD) risk factors (RFs) have a decreased predictive strength with higher ages. Whether the strength of relationship between these RFs and (...) (Circulation)
• 10:31
  Abstract 9188: Sex Differences in Cardiovascular Risk and Guideline-Based Preventive Medication Use Among Sudden Death Victims - Susan Keen Kaitlin Shartle Ross J Simpson Univ of North Carolina at Chapel Hill, Chapel Hill, NC Dept of Sociology, Univ of North Carolina at Chapel Hill, Chapel Hill, NC UNIVERSITY NC HEART, Chapel Hill, NC Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9188-A9188, November 16, 2021. Introduction:Atherosclerotic cardiovascular disease (ASCVD) is associated with an increased risk of sudden death. Preventive medications are recommended by clinical practice guidelines for those with elevated ASCVD (...) (Circulation)
• 10:31
  Abstract 9189: Diagnostic Validity of Genetic Testing for Hypertrophic Cardiomyopathy - A Systematic Review and Meta-Analysis - Melissa A Kelly Allison Cirino Brittany P Hansen Stephanie Harris Andrea M Murad Jaime Natoli Jennifer Malinowski Susan Christian Geisinger, Danville, PA Cardiovascular Div, Brigham and Women's Hosp, Boston, MA Cntr for Personalized Genetic Healthcare, Cleveland Clinic, OH Cardiovascular Genetics Program, Massachusetts General Hosp, Boston, MA Div of Genetic Medicine, Univ of Michigan, Ann Arbor, MI Southern California Permanente Med Group, Kaiser Permanente, Pasadena, CA Write Inscite, South Salem, NY Dept of Med Genetics, Univ of Alberta, Edmonton, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9189-A9189, November 16, 2021. Introduction:Hypertrophic cardiomyopathy (HCM) is a routine indication for genetic testing. However, our understanding of the impact of genetic testing on clinical outcomes is limited. This study systematically (...) (Circulation)
• 10:31
  Abstract 9191: Association of Cumulative Social Risk Score With Cardiovascular Outcomes in the Multi-Ethnic Study of Atherosclerosis - Aziz Hammoud Haiying Chen Alexander Ivanov Joseph Yeboah Miguel Cainzos-Achirica Khurram Nasir Alain G Bertoni Safi U Khan Michael J Blaha David M Herrington Michael D Shapiro Wake Forest Baptist Health, Winston-Salem, NC Wake Forest Sch of Medicine, Winston Salem, NC Wake Forest Baptist Health, Winston Salem, NC WAKE FOREST UNIVERSITY, Winston Salem, NC Cardiology, Houston Methodist DeBakey Heart & Vascular Cntr, Houston, TX Houston Methodist, Houston, TX WAKE FOREST UNIV SCHOOL MED, Winston Salem, NC West Virginia Univ, Morgantown, WV JOHNS HOPKINS HOSPITAL, Baltimore, MD WAKE FOREST (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9191-A9191, November 16, 2021. Introduction:Although the importance of social determinants of health is well-established in atherosclerotic cardiovascular disease (ASCVD), there is a need for a validated polysocial risk construct in the current (...) (Circulation)
• 10:31
  Abstract 9192: Efficacy and Safety of Dabigatran in the Treatment and Secondary Prophylaxis of Children With Congenital Heart Disease - Manuela Albisetti Igor Tartakovsky Jacqueline Halton Lisa Bomgaars Elizabeth Chalmers Lesley Mitchell Matteo Luciani Ildar Nurmeev Kirill Gorbatikov Eva Kleine Martina Brueckmann Leonardo Brandao Hematology Dept, Univ Children’s Hosp, Zürich, Switzerland Therapeutic Area Cardiovascular Medicine, Boehringer Ingelheim International GmbH, Ingelheim, Germany Univ of Ottawa, Children’s Hosp of Eastern Ontario, Ottawa, Canada Texas Children’s Cancer Cntr, Baylor College of Medicine, Houston, TX Royal Hosp for Children, Glasgow, Scotland, United Kingdom Univ of Alberta, Edmonton, Canada Pediatric (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9192-A9192, November 16, 2021. Introduction:Congenital heart disease (CHD) is associated with an increased frequency of thrombotic events in children, particularly in cyanotic conditions (i.e., single ventricles). Phase IIb/III clinical trials in (...) (Circulation)
• 10:31
  Abstract 9193: Peripheral Artery Disease and the Risk of Venous Thromboembolism - Daniel Sykora Shubhang K Bhatt Andrew S Tseng Marlene Girardo Christine Firth Alanna M Chamberlain Paul W Wennberg David Liedl Fadi E Shamoun Mayo Clinic Sch of Graduate Med Education, Rochester, MN Mayo Clinic Sch of Graduate Med Education, Scottsdale, AZ Rochester, MN Scottsdale, AZ PHOENIX, AZ MAYO CLINIC, Rochester, MN Mayo Clinic, Rochester, MN Dept of Cardiovascular Diseases, Mayo Clinic Arizona, Scottsdale, AZ Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9193-A9193, November 16, 2021. Introduction:Peripheral artery disease impacts 202 million patients worldwide and is commonly diagnosed via ankle-brachial index. PAD is associated with endothelial dysfunction, which is also common to venous (...) (Circulation)
• 10:31
  Abstract 9196: Innocuous Levels of Pulmonary Thrombosis Protect Against Inflammatory Lung Injury via Endothelial Arachidonate 15-Lipoxygenase and Hypoxia-Inducible Factor 1? - Colin E Evans Xianming Zhang Narsa Machireddy Youyang Zhao Northwestern Univ, Chicago, IL Northwestern Feinberg Sch of Med, Aurora, IL Northwestern U-Lurie Children's Hos, Chicago, IL Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9196-A9196, November 16, 2021. Introduction:Sepsis patients commonly suffer from lung thrombosis and sepsis-induced acute lung injury (ALI), but clinical trials of anti-coagulants in sepsis and ALI have failed, and the impact of varying severities (...) (Circulation)
• 10:31
  Abstract 9197: Lesion Size and Adverse Event Profile of the TactiFlex™ Ablation Catheter, Sensor Enabled™ in a Porcine Thigh Model - Jed Overmann Greg Ginn Nicholas Ambrosius Christopher Geurkink Zada Thamavong Jeffrey Fish Abbott, St. Paul, MN Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9197-A9197, November 16, 2021. Background:Advanced irrigated catheters, such as the FlexAbility™ Ablation Catheter, Sensor Enabled™ (FlexAbility SE), improve safety during RF ablation. Integration of contact force sensing technology with FlexAbility (...) (Circulation)
• 10:31
  Abstract 9199: A Novel Small Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics or Diastolic Function - Huamei He Tomas Baka James Balschi Alykhan Motani Khanh K Nguyen Qingxiang Liu Rebecca Slater brooke rock Chen Wang Christopher Hale Georgios Karamanlidis James J Hartman Fady I Malik jeff D reagan Ivan Luptak Brigham and Women's Hosp, Boston, MA BOSTON UNIV MEDICAL CTR, Boston, MA Amgen, South San Francisco, CA Dept of Cardiometabolic Disorders, Amgen, South San Francisco, CA Dept of Cardiometabolic Disorders, Amgen, Thousand Oaks, CA CYTOKINETICS, South San Francisco, (...) Circulation
  Circulation, Volume 144, Issue Suppl_1, Page A9199-A9199, November 16, 2021. Background:Current heart failure (HF) therapies improve cardiac energy balance and prolong survival by unloading the failing heart without targeting the underlying problem of reduced cardiac contractility. Traditional (...) (Circulation)