26 July

Circulation http://ahajournals.org/

• 11:00
  Donor Macrophages Modulate Rejection After Heart Transplantation - Benjamin J. Kopecky Hao Dun Junedh M. Amrute Chieh-Yu Lin Andrea L. Bredemeyer Yuriko Terada Peter O. Bayguinov Andrew L. Koenig Christian C. Frye James A.J. Fitzpatrick Daniel Kreisel Kory J. Lavine Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, MO. (B.J.K., J.M.A., A.L.B., A.L.K., K.J.L.) Department of Surgery, Washington University School of Medicine, St Louis, MO. (H.D., Y.T., C.C.F., D.K.) Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO. (C.-Y.L., D.K., K.J.L.) Washington University (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Cellular rejection after heart transplantation imparts significant morbidity and mortality. Current immunosuppressive strategies are imperfect, target recipient T cells, and have adverse effects. The innate immune response plays an essential role in the (...) (Circulation)
• 11:00
  Predictive Utility of a Validated Polygenic Risk Score for Long-Term Risk of Coronary Heart Disease in Young and Middle-Aged Adults - Sadiya S. Khan Courtney Page Daniel M. Wojdyla Yosef Y. Schwartz Philip Greenland Michael J. Pencina Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL. (S.S.K., P.G.) Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL. (S.S.K.) Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL. (Y.Y.S.) Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (C.P., D.M.W., (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Understanding the predictive utility of previously derived polygenic risk scores (PRSs) for long-term risk of coronary heart disease (CHD) and its additive value beyond traditional risk factors can inform prevention strategies.METHODS:Data from adults 20 (...) (Circulation)
• 11:00
  Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2 - Ling-Yue Sun Yu-Yan Lyu Heng-Yuan Zhang Zhi Shen Guan-Qiao Lin Na Geng Yu-Li Wang Lin Huang Ze-Hao Feng Xiao Guo Nan Lin Song Ding An-Cai Yuan Lan Zhang Kun Qian Jun Pu State Key Laboratory for Oncogenes and Related Genes, Department of Cardiology, Shanghai Jiao Tong University, Shanghai, China. (L.-Y.S., Y.-Y.L., H.-Y.Z., Z.S., G.-Q.L., N.G., Z.-H.F., X.G., N.L., S.D., A.-C.Y., J.P.) Department of Vascular Surgery, Shanghai Jiao Tong University, Shanghai, China. (Y.-L.W., L.Z.) Renji Hospital, School of Medicine, School of Biomedical Engineering and Med-X Research Institute, Shanghai (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Metabolic disorder increases the risk of abdominal aortic aneurysm (AAA). NRs (nuclear hormone receptors) have been increasingly recognized as important regulators of cell metabolism. However, the role of NRs in AAA development remains largely (...) (Circulation)

25 July

Circulation http://ahajournals.org/

• 08:00
  Collab, Virtualize, Democratize: A Conversation With the Founders of CardioNerds - Amit Goyal Daniel Ambinder Maryjane Farr Circulation
  Circulation, Volume 146, Issue 4, Page 269-275, July 26, 2022. (Circulation)
• 11:00
  Long-Term Leisure-Time Physical Activity Intensity and All-Cause and Cause-Specific Mortality: A Prospective Cohort of US Adults - Dong Hoon Lee Leandro F.M. Rezende Hee-Kyung Joh NaNa Keum Gerson Ferrari Juan Pablo Rey-Lopez Eric B. Rimm Fred K. Tabung Edward L. Giovannucci Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA Department of Preventive Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Sao Paulo, Brazil Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Family Medicine, Seoul National University Hospital, Seoul, (...) Circulation
  Circulation, Ahead of Print. Background:The 2018 physical activity guidelines for Americans recommend a minimum of 150 to 300 min/wk of moderate physical activity (MPA), 75 to 150 min/wk of vigorous physical activity (VPA), or an equivalent combination of both. However, it remains unclear (...) (Circulation)
• 08:00
  Management of Atrial Fibrillation Across the Spectrum of Heart Failure With Preserved and Reduced Ejection Fraction - Yogesh N.V. Reddy Barry A. Borlaug Bernard J. Gersh Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. Circulation
  Circulation, Volume 146, Issue 4, Page 339-357, July 26, 2022. Atrial fibrillation (AF) is the most common arrhythmia among patients with heart failure (HF), and HF is the most common cause of death for patients presenting with clinical AF. AF is frequently associated with pathological atrial (...) (Circulation)
• 08:00
  Should Polypills Be Used for Heart Failure With Reduced Ejection Fraction? - Ambarish Pandey Neil Keshvani Thomas J. Wang Division of Cardiology, Department of Medicine, UT Southwestern Medical Center, Dallas, TX. Circulation
  Circulation, Volume 146, Issue 4, Page 276-278, July 26, 2022. (Circulation)
• 08:00
  Letter by Madias and Madias Regarding Article, “Efficacy and Safety of Appropriate Shocks and Antitachycardia Pacing in Transvenous and Subcutaneous Implantable Defibrillators: Analysis of All Appropriate Therapy in the PRAETORIAN Trial” - Christopher Madias John E. Madias Cardiac Arrhythmia Center, Tufts Medical Center, Boston, MA (C.M.). Icahn School of Medicine at Mount Sinai, New York, NY (J.E.M.). Division of Cardiology, Elmhurst Hospital Center, NY (J.E.M.). Circulation
  Circulation, Volume 146, Issue 4, Page e8-e9, July 26, 2022. (Circulation)
• 08:00
  Response by van der Stuijt et al to Letter Regarding Article, “Efficacy and Safety of Appropriate Shocks and Antitachycardia Pacing in Transvenous and Subcutaneous Implantable Defibrillators: Analysis of All Appropriate Therapy in the PRAETORIAN Trial” - Willeke van der Stuijt Lonneke Smeding Louise R.A. Olde Nordkamp Reinoud E. Knops Amsterdam UMC, location University of Amsterdam, Amsterdam Cardiovascular Sciences, Department of Clinical and Experimental Cardiology, The Netherlands. Circulation
  Circulation, Volume 146, Issue 4, Page e10-e11, July 26, 2022. (Circulation)
• 08:00
  Effect of Empagliflozin on Kidney Biochemical and Imaging Outcomes in Patients With Type 2 Diabetes, or Prediabetes, and Heart Failure with Reduced Ejection Fraction (SUGAR-DM-HF) - Matthew M.Y. Lee Keith A. Gillis Katriona J.M. Brooksbank Sarah Allwood-Spiers Pauline Hall Barrientos Kirsty Wetherall Giles Roditi Bashair AlHummiany Colin Berry Ross T. Campbell Victor Chong Liz Coyle Kieran F. Docherty John G. Dreisbach Bernd Kuehn Catherine Labinjoh Ninian N. Lang Vera Lennie Kenneth Mangion Alex McConnachie Clare L. Murphy Colin J. Petrie John R. Petrie Kanishka Sharma Steven Sourbron Iain A. Speirits Joyce Thompson Paul Welsh Rosemary Woodward Ann Wright Aleksandra Radjenovic John J.V. McMurray Pardeep S. Jhund Mark C. Petrie Naveed Sattar Patrick B. Mark Institute (...) Circulation
  Circulation, Volume 146, Issue 4, Page 364-367, July 26, 2022. (Circulation)
• 08:00
  Correction to: Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure Circulation
  Circulation, Volume 146, Issue 4, Page e12-e12, July 26, 2022. (Circulation)
• 08:00
  Correction to: Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency Circulation
  Circulation, Volume 146, Issue 4, Page e13-e13, July 26, 2022. (Circulation)
• 08:00
  An Immune Checkpoint Inhibitor Heart: How CD45RA+ Effector Memory CD8+ T Cells (Temra) Are Implicated in Immune Checkpoint Inhibitor Myocarditis - Marinos Kallikourdis Gianluigi Condorelli Humanitas University, Pieve Emanuele, Italy (M.K., G.C.). Adaptive Immunity Laboratory (M.K.), Humanitas Research Hospital IRCCS, Rozzano, Italy. Cardio Center (G.C.), Humanitas Research Hospital IRCCS, Rozzano, Italy. Circulation
  Circulation, Volume 146, Issue 4, Page 336-338, July 26, 2022. (Circulation)
• 08:00
  SGLT2 Inhibitors: From Antihyperglycemic Agents to All-Around Heart Failure Therapy - Stefan D. Anker Muhammad Shariq Usman Javed Butler Department of Cardiology and Berlin Institute of Health Center for Regenerative Therapies (BCRT), German Centre for Cardiovascular Research (DZHK) partner site Berlin, Charité Universitätsmedizin Berlin, Germany (S.D.A.). Institute of Heart Diseases, Wroc?aw Medical University, Poland (S.D.A.). Department of Medicine, University of Mississippi, Jackson (M.S.U., J.B.). Baylor Scott and White Research Institute, Dallas, TX (...) Circulation
  Circulation, Volume 146, Issue 4, Page 299-302, July 26, 2022. (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 146, Issue 4, Page 358-363, July 26, 2022. (Circulation)

22 July

Circulation http://ahajournals.org/

• 11:00
  Retraction of: Transgenic Overexpression of Aldehyde Dehydrogenase-2 Rescues Chronic Alcohol Intake-Induced Myocardial Hypertrophy and Contractile Dysfunction Circulation
  Circulation, Ahead of Print. (Circulation)

18 July

Circulation http://ahajournals.org/

• 11:01
  Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart - Yuanbiao Zhao Andrew S. Riching Walter E. Knight Congwu Chi Lindsey J. Broadwell Yanmei Du Mostafa Abdel-Hafiz Amrut V. Ambardekar David C. Irwin Catherine Proenza Hongyan Xu Leslie A. Leinwand Lori A. Walker Kathleen C. Woulfe Michael R. Bristow Peter M. Buttrick Kunhua Song Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora. (Y.Z., A.S.R., W.E.K., C.C., Y.D., A.V.A., L.A.W., K.C.W., M.R.B., P.M.B., K.S.) Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado Anschutz Medical Campus, Aurora. (A.S.R., (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Abnormalities in Ca2+homeostasis are associated with cardiac arrhythmias and heart failure. Triadin plays an important role in Ca2+homeostasis in cardiomyocytes. Alternative splicing of a singletriadingene produces multiple triadin isoforms. The (...) (Circulation)
• 11:00
  Polygenic Risk Scores for Cardiovascular Disease: A Scientific Statement From the American Heart Association - Jack W. O’Sullivan Sridharan Raghavan Carla Marquez-Luna Jasmine A. Luzum Scott M. Damrauer Euan A. Ashley Christopher J. O’Donnell Cristen J. Willer Pradeep Natarajan Circulation
  Circulation, Ahead of Print. Cardiovascular disease is the leading contributor to years lost due to disability or premature death among adults. Current efforts focus on risk prediction and risk factor mitigation‚ which have been recognized for the past half-century. However, despite advances, (...) (Circulation)
• 11:00
  Effect of Patient-Reported Preprocedural Physical and Mental Health on 10-Year Mortality After Percutaneous or Surgical Coronary Revascularization - Masafumi Ono Patrick W. Serruys Scot Garg Hideyuki Kawashima Chao Gao Hironori Hara Mattia Lunardi Rutao Wang Neil O’Leary Joanna J. Wykrzykowska Jan J. Piek Michael J. Mack David R. Holmes Marie-Claude Morice Arie Pieter Kappetein Daniel J.F.M. Thuijs Thilo Noack Friedrich W. Mohr Piroze M. Davierwala John A. Spertus David J. Cohen Yoshinobu Onuma Amsterdam UMC, University of Amsterdam, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, The Netherlands (M.O., H.K., H.H., J.J.W., J.J.P.). Department of Cardiology, National University of (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Clinical and anatomical characteristics are often considered key factors in deciding between percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) in patients with complex coronary artery disease (CAD) such as left-main CAD or (...) (Circulation)
• 08:00
  Community-Based, Cluster-Randomized Pilot Trial of a Cardiovascular Mobile Health Intervention: Preliminary Findings of the FAITH! Trial - LaPrincess C. Brewer Sarah Jenkins Sharonne N. Hayes Ashok Kumbamu Clarence Jones Lora E. Burke Lisa A. Cooper Christi A. Patten Department of Cardiovascular Medicine (L.C.B., S.N.H.), Mayo Clinic College of Medicine, Rochester, MN. Department of Psychiatry and Psychology (C.A.P.), Mayo Clinic College of Medicine, Rochester, MN. Center for Health Equity and Community Engagement Research (L.C.B.), Mayo Clinic, Rochester, MN. Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences (S.J.), Mayo Clinic, Rochester, MN. Robert D. and Patricia E. Kern Center for (...) Circulation
  Circulation, Volume 146, Issue 3, Page 175-190, July 19, 2022. Background:African Americans continue to have suboptimal cardiovascular health (CVH) based on the American Heart Association Life’s Simple 7 (LS7), 7 health-promoting behaviors and biological risk factors (eg, physical activity, (...) (Circulation)
• 08:00
  Racial and Ethnic Differences in All-Cause and Cardiovascular Disease Mortality: The MESA Study - Wendy S. Post Karol E. Watson Spencer Hansen Aaron R. Folsom Moyses Szklo Steven Shea R. Graham Barr Gregory Burke Alain G. Bertoni Norrina Allen James S. Pankow Joao A.C. Lima Jerome I. Rotter Joel D. Kaufman W. Craig Johnson Richard A. Kronmal Ana V. Diez-Roux Robyn L. McClelland Division of Cardiology, Department of Medicine (W.S.P., J.A.C.L.), Johns Hopkins University, Baltimore, MD. Department of Epidemiology, Bloomberg School of Public Health (W.S.P., M.S.), Johns Hopkins University, Baltimore, MD. Division of Cardiology, Department of Internal Medicine, UCLA, Los Angeles, CA (...) Circulation
  Circulation, Volume 146, Issue 3, Page 229-239, July 19, 2022. Background:Despite improvements in population health, marked racial and ethnic disparities in longevity and cardiovascular disease (CVD) mortality persist. This study aimed to describe risks for all-cause and CVD mortality by race (...) (Circulation)
• 08:00
  Disparities in Cardiovascular Mortality Between Black and White Adults in the United States, 1999 to 2019 - Ashley N. Kyalwazi Eméfah C. Loccoh LaPrincess C. Brewer Elizabeth O. Ofili Jiaman Xu Yang Song Karen E. Joynt Maddox Robert W. Yeh Rishi K. Wadhera Richard A. and Susan F. Center for Outcomes Research in Cardiology, Beth Israel Deaconess Medical Center, Boston, MA (A.N.K., J.X., Y.S., R.W.Y., R.K.W.). Harvard Medical School, Boston, MA (A.N.K.). Department of Medicine, Brigham and Women’s Hospital, Boston, MA (E.C.L.). Department of Cardiovascular Medicine and Center for Health Equity and Community Engagement Research, Mayo Clinic, Rochester, MN (L.C.B.). Division of Cardiology and the (...) Circulation
  Circulation, Volume 146, Issue 3, Page 211-228, July 19, 2022. Background:Black adults experience a disproportionately higher burden of cardiovascular risk factors and disease in comparison with White adults in the United States. Less is known about how sex-based disparities in cardiovascular (...) (Circulation)
• 08:00
  Far Apart, but Close at Heart: The Importance of Understanding Patient Barriers to Telehealth and Potential Solutions - Leslie Eiland Andjela Drincic Division of Diabetes, Endocrinology and Metabolism, University of Nebraska Medical Center, Omaha. Circulation
  Circulation, Volume 146, Issue 3, Page 147-149, July 19, 2022. (Circulation)
• 08:00
  Broadening the Pool of Mentors for Historically Underrepresented Trainees and Faculty in Cardiology - Mercedes R. Carnethon Philip Greenland Department of Preventive Medicine (M.R.C., P.G.), Northwestern University Feinberg School of Medicine, Chicago, IL. Department of Medicine (Cardiology) (P.G.), Northwestern University Feinberg School of Medicine, Chicago, IL. Circulation
  Circulation, Volume 146, Issue 3, Page 150-152, July 19, 2022. (Circulation)
• 08:00
  Achieving Health Equities in Indigenous Peoples in Canada: Learnings Adaptable for Diverse Populations - Peter P. Liu Malcolm King Alexandra King University of Ottawa Heart Institute, University of Ottawa, Canada (P.P.L.). Department of Community Health and Epidemiology (M.K.), University of Saskatchewan, Saskatoon, Canada. Cameco Chair in Indigenous Health and Wellness (A.K.), University of Saskatchewan, Saskatoon, Canada. Circulation
  Circulation, Volume 146, Issue 3, Page 153-155, July 19, 2022. (Circulation)
• 08:00
  Leaving the Social Vacuum: Expanding Cardiovascular Guidelines to Embrace Equity - Jared W. Magnani LaPrincess C. Brewer Center for Research on Health Care, Department of Medicine (J.W.M.), University of Pittsburgh, PA. Department of Cardiovascular Medicine, Mayo Clinic College of Medicine, Rochester, MN (L.C.B.). Center for Health Equity and Community Engagement Research, Mayo Clinic, Rochester, MN (L.C.B.). Circulation
  Circulation, Volume 146, Issue 3, Page 156-158, July 19, 2022. (Circulation)
• 08:00
  Evolving Trends and Widening Racial Disparities in Children Listed for Heart Transplantation in the United States - M. Mujeeb Zubair Qiudong Chen Georgina Rowe George Gill Jason Thomas Shrishiv A. Timbalia Asishana A. Osho Michael E. Bowdish Vikram Sood Kurt R. Schumacher Joanna Chikwe Richard W. Kim Department of Cardiac Surgery, Cedars-Sinai Medical Center, Los Angeles, CA (M.M.Z., Q.C., G.R., G.G., J.T., A.A.O., M.E.B., J.C., R.W.K.). Department of Vascular Surgery, Houston Methodist Hospital, Houston, TX (S.A.T.). Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA (A.A.O.). University of Michigan Congenital Heart Center, C. S. Mott Children’s Hospital, Ann Arbor, MI (V.S., (...) Circulation
  Circulation, Volume 146, Issue 3, Page 262-264, July 19, 2022. (Circulation)
• 08:00
  Race and Ethnicity Stratification for Polygenic Risk Score Analyses May Mask Disparities in Hispanics - Shoa L. Clarke Rose D.L. Huang Austin T. Hilliard Catherine Tcheandjieu Julie Lynch Scott M. Damrauer Kyong-Mi Chang Philip S. Tsao Themistocles L. Assimes VA Palo Alto Health Care System, CA (S.L.C., R.D.L.H., A.T.H., C.T., P.S.T., T.L.A.). Department of Medicine, Division of Cardiovascular Medicine (S.L.C., A.T.H., C.T., P.S.T., T.L.A.), Stanford University School of Medicine, CA. Cardiovascular Institute (P.S.T., T.L.A.), Stanford University School of Medicine, CA. Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston (...) Circulation
  Circulation, Volume 146, Issue 3, Page 265-267, July 19, 2022. (Circulation)
• 08:00
  Toward a Broader Conceptualization of Disparities and Solutions - Mercedes R. Carnethon Fatima Rodriguez Karol E. Watson Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (M.R.C.). Circulation
  Circulation, Volume 146, Issue 3, Page 145-146, July 19, 2022. (Circulation)
• 08:00
  Whose Streets? Neighborhood-Level Determinants of Atrial Fibrillation Care - Utibe R. Essien Amber E. Johnson Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, PA (U.R.E., A.E.J.). Division of General Internal Medicine (U.R.E.), University of Pittsburgh School of Medicine, PA. Division of Cardiology (A.E.J.), University of Pittsburgh School of Medicine, PA. Circulation
  Circulation, Volume 146, Issue 3, Page 172-174, July 19, 2022. (Circulation)
• 08:00
  Creation of the American Heart Association Journals’ Equity, Diversity, and Inclusion Editorial Board: The Next Step to Achieving the 2024 Impact Goal - Eldrin F. Lewis Christine Beaty Johannes Boltze Khadijah Breathett Walter K. Clair Lisa de las Fuentes Utibe R. Essien Heather Goodell H. E. Hinson Kiarri N. Kershaw Joshua W. Knowles Sula Mazimba Mahasin Mujahid Henry E. Okafor Kyung Woo Park Jonathan Schultz Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University School of Medicine, Palo Alto, CA (E.F.L., J.W.K.). Scientific Publishing, American Heart Association, Dallas, TX (C.B., H.G., J.S.). The University of Warwick, School of Life Sciences, United Kingdom (J.B.). Indiana University School of Medicine, (...) Circulation
  Circulation, Ahead of Print. (Circulation)

11 July

Circulation http://ahajournals.org/

• 11:01
  Effects of Cuisine-Based Chinese Heart-Healthy Diet in Lowering Blood Pressure Among Adults in China: Multicenter, Single-Blind, Randomized, Parallel Controlled Feeding Trial - Yanfang Wang Lin Feng Guo Zeng Huilian Zhu Jianqin Sun Pei Gao Jihong Yuan Xi Lan Shuyi Li Yanfang Zhao Xiayan Chen Hongli Dong Si Chen Zhen Li Yidan Zhu Ming Li Xiang Li Zhenquan Yang Huijuan Li Hai Fang Gaoqiang Xie Pao-Hwa Lin Junshi Chen Yangfeng Wu Peking University Clinical Research Institute, Peking University First Hospital, Beijing, China (Y. Wang, L.F., P.G., X.C., Y. Zhu, H.L., G.X., Y. Wu). Department of Nutrition, School of Public Health, Sichuan University, Chengdu, China (G.Z., X. Lan, H.D.). Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of (...) Circulation
  Circulation, Volume 146, Issue 4, Page 303-315, July 26, 2022. Background:More than one-fifth of the world’s population consumes Chinese cuisines regularly, but no evidence-based healthy diets fitting the Chinese food culture are available for implementation.Methods:A multicenter, patient- and (...) (Circulation)
• 11:01
  Elucidating the Clinical Implications and Pathophysiology of Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction: A Call to Action: A Science Advisory From the American Heart Association - Evan L. Brittain Thenappan Thenappan Jessica H. Huston Vineet Agrawal Yen-Chun Lai Debra Dixon John J. Ryan Eldrin F. Lewis Margaret M. Redfield Sanjiv J. Shah Bradley A. Maron Circulation
  Circulation, Ahead of Print. This science advisory focuses on the need to better understand the epidemiology, pathophysiology, and treatment of pulmonary hypertension in patients with heart failure with preserved ejection fraction. This clinical phenotype is important because it is common, is (...) (Circulation)
• 11:00
  Renal and Vascular Effects of Combined SGLT2 and Angiotensin-Converting Enzyme Inhibition - Yuliya Lytvyn Karen Kimura Nuala Peter Vesta Lai Josephine Tse Leslie Cham Bruce A. Perkins Nima Soleymanlou David Z.I. Cherney Department of Medicine, Division of Nephrology, Toronto General Hospital, University of Toronto, Canada. (Y.L., V.L., J.T., L.C., D.Z.I.C.) Temerty Faculty of Medicine, University of Toronto, Canada. (Y.L.) Department of Medicine, Division of Endocrinology and Metabolism, Mount Sinai Hospital, University of Toronto, Canada. (B.A.P.) Boehringer Ingelheim Canada Ltd/Ltée, Burlington (K.K.). Biberach an der Riss, Germany (N.P.). Boehringer Ingelheim Pharmaceuticals (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:The cardiorenal effects of sodium-glucose cotransporter 2 inhibition (empagliflozin 25 mg QD) combined with angiotensin-converting enzyme inhibition (ramipril 10 mg QD) were assessed in this mechanistic study in patients with type 1 diabetes with (...) (Circulation)
• 08:00
  High Circulating Triglycerides Are Most Commonly a Marker of Ectopic Fat Accumulation: Connecting the Clues to Advance Lifestyle Interventions - Naveed Sattar Darren K. McGuire Jason M.R. Gill Institute of Cardiovascular and Medical Sciences, University of Glasgow, UK (N.S., J.M.R.G.). University of Texas Southwestern Medical Center and Parkland Health and Hospital System, Dallas (D.K.M.). Circulation
  Circulation, Volume 146, Issue 2, Page 77-79, July 12, 2022. (Circulation)
• 08:00
  Letter by Groothof et al Regarding Article, “Efpeglenatide and Clinical Outcomes With and Without Concomitant Sodium-Glucose Cotransporter-2 Inhibition Use in Type 2 Diabetes: Exploratory Analysis of the AMPLITUDE-O Trial” - Dion Groothof Adrian Post Stephan J.L. Bakker Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, the Netherlands. Circulation
  Circulation, Volume 146, Issue 2, Page e5-e6, July 12, 2022. (Circulation)
• 08:00
  Response by Lam and Gerstein to Letter Regarding Article, “Efpeglenatide and Clinical Outcomes With and Without Concomitant Sodium-Glucose Cotransporter-2 Inhibition Use in Type 2 Diabetes: Exploratory Analysis of the AMPLITUDE-O Trial” - Carolyn S.P. Lam Hertzel C. Gerstein National Heart Centre Singapore & Duke-National University of Singapore (C.S.P.L.). Population Health Research Institute, Hamilton Health Sciences and McMaster University, Canada (H.C.G.). Circulation
  Circulation, Volume 146, Issue 2, Page e7-e7, July 12, 2022. (Circulation)
• 08:00
  Nurse Navigators Cut Stroke Readmissions by Half - Bridget M. Kuehn Circulation
  Circulation, Volume 146, Issue 2, Page 140-141, July 12, 2022. (Circulation)
• 08:00
  Heart Failure With Reduced Ejection Fraction: “The Importance of Being Frail” - Linda R. Peterson Andrew R. Coggan Washington University School of Medicine in Saint Louis, MO (L.R.P.). Indiana University Purdue University Indianapolis, IN (A.R.C.). Circulation
  Circulation, Volume 146, Issue 2, Page 91-93, July 12, 2022. (Circulation)

8 July

Circulation http://ahajournals.org/

• 11:00
  Assessment of Clinical Worsening End Points as a Surrogate for Mortality in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - Élodie Tremblay Camille Gosselin Vicky Mai Annie C. Lajoie Roubi Kilo Jason Weatherald Yves Lacasse Sebastien Bonnet Jean-Christophe Lega Steeve Provencher Institut Universitaire de Cardiologie et de Pneumologie de Québec Research Center, Université Laval, Quebec City, Canada. (E.T., C.G., V.M., A.C.L., Y.L., S.B., S.P.) Department of Medicine, Université Laval, Quebec City, Canada. (Y.L., S.B., S.P.) Pulmonary Hypertension Research Group (http://phrg.ca) (E.T., C.G., V.M., A.C.L., S.B., S.P.). Pôle De Santé Publique, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, F-69310, Pierre-Bénite, (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Clinical worsening (CW) is a composite end point commonly used in pulmonary arterial hypertension (PAH) trials. We aimed to assess the trial-level surrogacy of CW for mortality in PAH trials, and whether the various CW components were similar in terms of (...) (Circulation)
• 11:00
  Characteristics of Heart Failure With Preserved Ejection Fraction Across the Range of Left Ventricular Ejection Fraction - Sebastian Rosch Karl-Patrik Kresoja Christian Besler Karl Fengler Anne Rebecca Schöber Maximilian von Roeder Christian Lücke Matthias Gutberlet Karin Klingel Holger Thiele Karl-Philipp Rommel Philipp Lurz Department of Cardiology, Heart Center Leipzig at University of Leipzig, Germany. (S.R., K.-P.K., C.B., K.F., A.R.S., M.v.R., H.T., K.-P.R., P.L.) Department of Radiology, Heart Center Leipzig at University of Leipzig, Germany. (C.L., M.G.) Department of Cardiopathology, Institute for Pathology and Neuropathology, University Hospital Tübingen, Germany (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Recent trial data suggest that stratification of patients with heart failure with preserved ejection fraction (HFpEF) according to left ventricular ejection fraction (LVEF) provides a means for dissecting different treatment responses. However, the (...) (Circulation)
• 11:00
  Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles - Mohammed Rabiul Hosen Philip Roger Goody Andreas Zietzer Xu Xiang Sven Thomas Niepmann Alexander Sedaghat Vedat Tiyerili Ramesh Chennupati Joseph B. Moore Reinier A. Boon Shizuka Uchida Jan-Malte Sinning Sebastian Zimmer Eicke Latz Nikos Werner Georg Nickenig Felix Jansen Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Venusberg-Campus Germany. (M.R.H., P.R.G., A.Z., X.X., S.T.N., A.S., V.T., S.Z., G.N., F.J.) Institute of Innate Immunity, University Hospital Bonn, Venusberg-Campus Germany. (E.L.) Department of International Medical Center, Affiliated (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Transcatheter aortic valve replacement (TAVR) is a well-established treatment option for high- and intermediate-risk patients with severe symptomatic aortic valve stenosis. A majority of patients exhibit improvements in left ventricular ejection fraction (...) (Circulation)
• 11:00
  Deformation of Transcatheter Aortic Valve Prostheses: Implications for Hypoattenuating Leaflet Thickening and Clinical Outcomes - Miho Fukui Vinayak N. Bapat Santiago Garcia Marshall W. Dworak Go Hashimoto Hirotomo Sato Mario Gössl Maurice Enriquez-Sarano John R. Lesser João L. Cavalcante Paul Sorajja Cardiovascular Imaging Research Center and Core Laboratory, Minneapolis Heart Institute Foundation, MN. (M.F., G.H., J.L.C.) Valve Science Center, Minneapolis Heart Institute Foundation, MN. (V.N.B., S.G., M.W.D., H.S., M.G., M.E.-S., J.R.L., P.S.) Minneapolis Heart Institute at Abbott Northwestern Hospital, MN (V.N.B., S.G., M.G., M.E.-S., J.R.L., J.L.C., (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Although transcatheter aortic valve replacement (TAVR) therapy continues to grow, there have been concerns about the occurrence of hypoattenuating leaflet thickening (HALT), which may affect prosthesis function or durability. This study aimed to examine (...) (Circulation)

7 July

Circulation http://ahajournals.org/

• 11:00
  Escalating and De-escalating Temporary Mechanical Circulatory Support in Cardiogenic Shock: A Scientific Statement From the American Heart Association - Bram J. Geller Shashank S. Sinha Navin K. Kapur Marie Bakitas Leora B. Balsam Joanna Chikwe Deborah G. Klein Ajar Kochar Sofia C. Masri Daniel B. Sims Graham C. Wong Jason N. Katz Sean van Diepen Circulation
  Circulation, Ahead of Print. The use of temporary mechanical circulatory support in cardiogenic shock has increased dramatically despite a lack of randomized controlled trials or evidence guiding clinical decision-making. Recommendations from professional societies on temporary mechanical (...) (Circulation)

6 July

Circulation http://ahajournals.org/

• 11:00
  Restoration of Cardiomyogenesis in Aged Mouse Hearts by Voluntary Exercise - Carolin Lerchenmüller Ana Vujic Sonja Mittag Annie Wang Charles P. Rabolli Chiara Heß Fynn Betge Ashraf Y. Rangrez Malay Chaklader Christelle Guillermier Frank Gyngard Jason D. Roh Haobo Li Matthew L. Steinhauser Norbert Frey Beverly Rothermel Christoph Dieterich Anthony Rosenzweig Richard T. Lee Department of Cardiology, University Hospital Heidelberg, Germany (C.L., S.M., C.P.R., C.H., F.B., A.Y.R., N.F., C.D.). German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Germany (C.L., S.M., F.B., N.F., C.D.). Cardiology Division and Corrigan Minehan Heart Center, (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:The human heart has limited capacity to generate new cardiomyocytes and this capacity declines with age. Because loss of cardiomyocytes may contribute to heart failure, it is crucial to explore stimuli of endogenous cardiac regeneration to favorably shift (...) (Circulation)

5 July

Circulation http://ahajournals.org/

• 08:00
  Correction to: Genetic Landscape of the ACE2 Coronavirus Receptor Circulation
  Circulation, Volume 146, Issue 1, Page e4-e4, July 5, 2022. (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 146, Issue 1, Page 64-68, July 5, 2022. (Circulation)
• 08:00
  Circulation Editors and Editorial Board Circulation
  Circulation, Volume 146, Issue 1, Page 1-3, July 5, 2022. (Circulation)
• 08:00
  Endovascular Therapy for Acute Basilar Artery Occlusion - Graeme J. Hankey Medical School, Faculty of Health and Medical Sciences, University of Western Australia, Perth. Perron Institute for Neurological and Translational Science, Queen Elizabeth II Medical Centre, Perth, Australia. Department of Neurology, Sir Charles Gairdner Hospital, Perth, Australia. Circulation
  Circulation, Volume 146, Issue 1, Page 18-20, July 5, 2022. (Circulation)
• 08:00
  It Is Time to Offer Genetic Testing to Women With Peripartum Cardiomyopathy - Zoltan Arany Perelman School of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia. Circulation
  Circulation, Volume 146, Issue 1, Page 4-5, July 5, 2022. (Circulation)
• 08:00
  Promoting Nutrition Security Through Policies and Programs - Keith Churchwell Stephanie Scarmo Donald M. Lloyd-Jones Yale New Haven Hospital, CT (K.C.). American Heart Association, Dallas, TX (S.S.). Northwestern University Feinberg School of Medicine, Chicago, IL (D.M.L.-J.). Circulation
  Circulation, Volume 146, Issue 1, Page e1-e2, July 5, 2022. (Circulation)
• 08:00
  Impaired AMP-Activated Protein Kinase Signaling in Heart Failure With Preserved Ejection Fraction–Associated Atrial Fibrillation - Dan Tong Gabriele G. Schiattarella Nan Jiang Daniel Daou Yuxuan Luo Mark S. Link Sergio Lavandero Thomas G. Gillette Joseph A. Hill Department of Internal Medicine (Cardiology) (D.T., N.J., D.D., Y.L., M.L., S.L., J.A.H.), University of Texas Southwestern Medical Center, Dallas. Department of Molecular Biology (J.A.H.), University of Texas Southwestern Medical Center, Dallas. Center for Cardiovascular Research (CCR), Department of Cardiology, Charité - Universitätsmedizin Berlin, Germany (G.G.S.). DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Germany (G.G.S.). (...) Circulation
  Circulation, Volume 146, Issue 1, Page 73-76, July 5, 2022. (Circulation)

1 July

Circulation http://ahajournals.org/

• 11:00
  High-Sensitivity Cardiac Troponin and the 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guidelines for the Evaluation and Diagnosis of Acute Chest Pain - Yader Sandoval Fred S. Apple Simon A. Mahler Richard Body Paul O. Collinson Allan S. Jaffe Departments of Cardiovascular Diseases, Mayo Clinic, Rochester, MN. (Y.S., A.S.J.) Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. (A.S.J.) Department of Laboratory Medicine and Pathology, Hennepin Healthcare/Hennepin County Medical Center and University of Minnesota, Minneapolis (F.S.A.). Department of Emergency Medicine, Wake Forest School of Medicine, Winston-Salem, NC (S.A.M.). Emergency Department, Manchester University NSH Foundation Trust, Manchester Academic Health Science (...) Circulation
  Circulation, Ahead of Print. The 2021 American Heart Association/American College of Cardiology/American Society of Echocardiography/American College of Chest Physicians/Society for Academic Emergency Medicine/Society of Cardiovascular Computed Tomography/Society for Cardiovascular Magnetic (...) (Circulation)
• 11:00
  Trials and Tribulations of Randomized Clinical Trials - Robert A Harrington Medicine, Stanford University, UNITED STATES Circulation
  Circulation, Ahead of Print. (Circulation)

30 June

Circulation http://ahajournals.org/

• 11:00
  Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab - Emil Hagström P. Gabriel Steg Michael Szarek Deepak L. Bhatt Vera A. Bittner Nicolas Danchin Rafael Diaz Shaun G. Goodman Robert A. Harrington J. Wouter Jukema Evangelos Liberopoulos Nikolaus Marx Jennifer McGinniss Garen Manvelian Robert Pordy Michel Scemama Harvey D. White Andreas M. Zeiher Gregory G. Schwartz Uppsala University, Department of Medical Sciences, and Uppsala Clinical Research Center, Sweden (E.H.). Department of Cardiology, Université de Paris, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, FACT (French Alliance for Cardiovascular Trials), and INSERM U1148, France (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein (...) (Circulation)

29 June

Circulation http://ahajournals.org/

• 11:00
  Effects of Early Empagliflozin Initiation on Diuresis and Kidney Function in Patients With Acute Decompensated Heart Failure (EMPAG-HF) - P. Christian Schulze Jürgen Bogoviku Julian Westphal Pawel Aftanski Franz Haertel Sissy Grund Stephan von Haehling Ulrike Schumacher Sven Möbius-Winkler Martin Busch Department of Internal Medicine I, Division of Cardiology, Angiology and Intensive Medical Care (P.C.S., J.B., J.W., P.A., F.H., S.G., S.M.-W.), Friedrich-Schiller-University, University Hospital Jena, Germany. Center for Clinical Studies (U.S.), Friedrich-Schiller-University, University Hospital Jena, Germany. Department of Internal Medicine III, Division of Nephrology (M.B.), Friedrich-Schiller-University, University Hospital (...) Circulation
  Circulation, Volume 146, Issue 4, Page 289-298, July 26, 2022. Background:Effective diuretic regimens using loop diuretics in patients with acute decompensated heart failure are often limited by the development of worsening kidney function. Sodium-glucose cotransporter-2 inhibitors induce (...) (Circulation)
• 11:01
  Life’s Essential 8: Updating and Enhancing the American Heart Association’s Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association - Donald M. Lloyd-Jones Norrina B. Allen Cheryl A.M. Anderson Terrie Black LaPrincess C. Brewer Randi E. Foraker Michael A. Grandner Helen Lavretsky Amanda Marma Perak Garima Sharma Wayne Rosamond Circulation
  Circulation, Ahead of Print. In 2010, the American Heart Association defined a novel construct of cardiovascular health to promote a paradigm shift from a focus solely on disease treatment to one inclusive of positive health promotion and preservation across the life course in populations and (...) (Circulation)
• 11:00
  Status of Cardiovascular Health in US Adults and Children Using the American Heart Association's New "Life's Essential 8" Metrics: Prevalence Estimates from the National Health and Nutrition Examination Survey (NHANES), 2013-2018 - Donald M. Lloyd-Jones Hongyan Ning Darwin Labarthe LaPrincess Brewer Garima Sharma Wayne Rosamond Randi E. Foraker Terrie Black Michael A. Grandner Norrina B. Allen Cheryl Anderson Helen Lavretsky Amanda M. Perak Northwestern University Feinberg School of Medicine, Chicago, IL Mayo Clinic College of Medicine, Rochester, MN Johns Hopkins University School of Medicine, Baltimore, MD University of North Carolina Gillings School of Public Health, Chapel Hill, NC Washington University School of Medicine, St. Louis, MO University of Massachusetts Amherst College of Nursing, Amherst, MA (...) Circulation
  Circulation, Ahead of Print. Background:The American Heart Association (AHA) recently published an updated algorithm for quantifying cardiovascular health (CVH)—the "Life's Essential 8™" score. We quantified US levels of CVH using the new score.Methods:We included non-pregnant, (...) (Circulation)
• 11:00
  Detection of G Protein–Coupled Receptor Autoantibodies in Postural Orthostatic Tachycardia Syndrome Using Standard Methodology - Juliette Hall Kate M. Bourne Steven Vernino Viktor Hamrefors Isabella Kharraziha Jan Nilsson Robert S. Sheldon Artur Fedorowski Satish R. Raj Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Canada (J. H., K.M.B., R.S.S., S.R.R.). Department of Neurology, UT Southwestern Medical Center, Dallas, TX (S.V.). Department of Clinical Sciences, Lund University, Malmö, Sweden (V.H., I.K., J.N., A.F.). Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden (V.H.). Department of Cardiology, Karolinska University (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Postural orthostatic tachycardia syndrome (POTS) is a disorder of orthostatic intolerance that primarily affects women of childbearing age. The underlying pathophysiology of POTS is not fully understood, but it has been suggested that autoimmunity may (...) (Circulation)

28 June

Circulation http://ahajournals.org/

• 11:00
  Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor–Induced Myocarditis - Han Zhu Francisco X. Galdos Daniel Lee Sarah Waliany Yuhsin Vivian Huang Julia Ryan Katherine Dang Joel W. Neal Heather A. Wakelee Sunil A. Reddy Sandy Srinivas Lih-Ling Lin Ronald M. Witteles Holden T. Maecker Mark M. Davis Patricia K. Nguyen Sean M. Wu Department of Medicine (H.Z., S.W., J.W.N., H.A.W., S.A.R., S.S., R.M.W., P.K.N., S.M.W.), Stanford University, CA. Stanford Cardiovascular Institute (H.Z., F.X.G., D.L., J.R., R.M.W.‚ P.K.N., S.M.W.), Stanford University, CA. Stanford Cancer Institute (J.W.N., H.A.W., S.A.R., S.S.), Stanford University, CA. Howard Hughes Medical Institute (...) Circulation
  Circulation, Volume 146, Issue 4, Page 316-335, July 26, 2022. Background:Immune checkpoint inhibitors (ICIs) are monoclonal antibodies used to activate the immune system against tumor cells. Despite therapeutic benefits, ICIs have the potential to cause immune-related adverse events such as (...) (Circulation)
• 11:00
  Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1?, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy - Paul M. Ridker Nader Rifai Jean MacFadyen Robert J. Glynn Lixia Jiao Ph. Gabriel Steg Michael Miller Eliot A. Brinton Terry A. Jacobson Jean-Claude Tardif Christie M. Ballantyne R. Preston Mason Deepak L. Bhatt Brigham and Women’s Hospital, Boston, MA (P.M.R., J.M., R.J.G., R.P.M., D.L.B.). Children’s Hospital Medical Center, Boston, MA (N.R.). Amarin Pharma, Bridgewater, NJ (L.J.). Université de Paris, FACT and INSERM-U1148, F75018 and Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, France (P.G.S.). University of Maryland School of Medicine, Baltimore (M.M.). Utah Lipid Center, Salt (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:REDUCE-IT (Reduction of Cardiovascular Events With Icosapent Ethyl—Intervention Trial) reported a 25% relative risk reduction in major adverse cardiovascular events with use of icosapent ethyl compared with pharmaceutical grade mineral oil. The mechanisms (...) (Circulation)
• 11:00
  Empagliflozin for Heart Failure With Preserved Left Ventricular Ejection Fraction With and Without Diabetes - Gerasimos Filippatos Javed Butler Dimitrios Farmakis Faiez Zannad Anne Pernille Ofstad João Pedro Ferreira Jennifer B. Green Julio Rosenstock Sven Schnaidt Martina Brueckmann Stuart J. Pocock Milton Packer Stefan D. Anker National and Kapodistrian University of Athens School of Medicine, Athens University Hospital Attikon, Greece (G.F.). Baylor Scott and White Research Institute, Dallas, TX (J.B.). Department of Medicine, University of Mississippi School of Medicine, Jackson (J.B.). University of Cyprus Medical School, Nicosia (D.F.). Centre d’Investigations Cliniques Plurithématique 14-33, (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Empagliflozin improves outcomes in patients with heart failure with a preserved ejection fraction, but whether the effects are consistent in patients with and without diabetes remains to be elucidated.METHODS:Patients with class II through IV heart (...) (Circulation)

27 June

Circulation http://ahajournals.org/

• 11:00
  Novel Smooth Muscle Ca2+-Signaling Nanodomains in Blood Pressure Regulation - Yen-Lin Chen Zdravka Daneva Maniselvan Kuppusamy Matteo Ottolini Thomas M. Baker Eliska Klimentova Soham A. Shah Jennifer D. Sokolowski Min S. Park Swapnil K. Sonkusare Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville. (Y.-L.C., Z.D., M.K., M.O., T.M.B., E.K., S.K.S.) Departments of Neurosurgery, University of Virginia, Charlottesville. (S.A.S.) Biomedical Engineering, University of Virginia, Charlottesville. (J.D.S., M.S.P.) Molecular Physiology and Biological Physics, University of Virginia, Charlottesville. (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Ca2+signals in smooth muscle cells (SMCs) contribute to vascular resistance and control blood pressure. Increased vascular resistance in hypertension has been attributed to impaired SMC Ca2+signaling mechanisms. In this regard, transient receptor (...) (Circulation)

24 June

Circulation http://ahajournals.org/

• 11:00
  Socioeconomic Deprivation: An Important, Largely Unrecognized Risk Factor in Primary Prevention of Cardiovascular Disease - Dorien M. Kimenai Leah Pirondini John Gregson David Prieto Stuart J. Pocock Pablo Perel Tilly Hamilton Paul Welsh Archie Campbell David J. Porteous Caroline Hayward Naveed Sattar Nicholas L. Mills Anoop S.V. Shah British Heart Foundation Centre for Cardiovascular Science (D. M.K., T.H., N.L.M.), University of Edinburgh, United Kingdom. Centre for Genomic and Experimental Medicine (A.C., D.J.P.), University of Edinburgh, United Kingdom. Medical Research Council Human Genetics Unit (C.H.), University of Edinburgh, United Kingdom. Institute of Genetics and Cancer, Usher Institute (N.L.M.), (...) Circulation
  Circulation, Volume 146, Issue 3, Page 240-248, July 19, 2022. Background:Socioeconomic deprivation is associated with higher cardiovascular morbidity and mortality. Whether deprivation status should be incorporated in more cardiovascular risk estimation scores remains unclear. This study (...) (Circulation)

23 June

Circulation http://ahajournals.org/

• 11:00
  Effects of Coronary Artery Disease–Associated Variants on Vascular Smooth Muscle Cells - Charles U. Solomon David G. McVey Catherine Andreadi Peng Gong Lenka Turner Paulina J. Stanczyk Sonja Khemiri Julie C. Chamberlain Wei Yang Tom R. Webb Christopher P. Nelson Nilesh J. Samani Shu Ye Department of Cardiovascular Sciences, University of Leicester, and National Institute for Health Research Leicester Biomedical Research Centre, UK (C.U.S., D.G.M., C.A., P.G., L.T., P.J.S., S.K., J.C.C., T.R.W., C.P.N., J.N.S., S.Y.). Shantou University Medical College, China (W.Y., S.Y.). Cardiovascular Disease Translational Research Programme, Department of Medicine, National University of (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Genome-wide association studies have identified many genetic loci that are robustly associated with coronary artery disease (CAD). However, the underlying biological mechanisms are still unknown for most of these loci, hindering the progress to medical (...) (Circulation)

21 June

Circulation http://ahajournals.org/

• 11:00
  Association of Extreme Heat and Cardiovascular Mortality in the United States: A County-Level Longitudinal Analysis From 2008 to 2017 - Sameed Ahmed M. Khatana Rachel M. Werner Peter W. Groeneveld Division of Cardiovascular Medicine (S.A.M.K.), University of Pennsylvania, Philadelphia. Penn Cardiovascular Outcomes, Quality, & Evaluative Research Center (S.A.M.K., P.W.G.), University of Pennsylvania, Philadelphia. Division of General Internal Medicine (R.M.W., P.W.G.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. The Leonard Davis Institute of Health Economics (S.A.M.K., R.M.W., P.W.G.), University of Pennsylvania, Philadelphia. Center for Health Equity Research and Promotion, Michael J. Crescenz (...) Circulation
  Circulation, Volume 146, Issue 3, Page 249-261, July 19, 2022. Background:Extreme-heat events are increasing as a result of climate change. Prior studies, typically limited to urban settings, suggest an association between extreme heat and cardiovascular mortality. However, the extent of the (...) (Circulation)
• 11:00
  Cost-Effectiveness of Catheter Ablation Versus Antiarrhythmic Drug Therapy in Atrial Fibrillation: The CABANA Randomized Clinical Trial - Derek S. Chew Yanhong Li Patricia A. Cowper Kevin J. Anstrom Jonathan P. Piccini Jeanne E. Poole Melanie R. Daniels Kristi H. Monahan Linda Davidson-Ray Tristram D. Bahnson Hussein R. Al-Khalidi Kerry L. Lee Douglas L. Packer Daniel B. Mark Duke Clinical Research Institute, Duke University, Durham, NC. (D.S.C., Y.L., P.A.C., K.J.A., J.P.P., M.R.O., L.D.-R., T.D.B., H.R.A.-K., K.L.L., D.L.P., D.B.M.) Department of Biostatistics and Bioinformatics (K.J.A., H.R.A.-K., K.L.L.) Department of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (D.S.C.). (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:In the CABANA trial (Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation), catheter ablation did not significantly reduce the primary end point of death, disabling stroke, serious bleeding, or cardiac arrest compared with drug therapy (...) (Circulation)
• 10:24
  Around and Around…A Wide Complex Tachycardia - Ricardo Avendaño Nimrod Lavi Lynda E. Rosenfeld Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT. Circulation
  Circulation, Volume 145, Issue 25, Page 1867-1869, June 21, 2022. (Circulation)
• 10:24
  Rivaroxaban 2.5 mg Twice Daily Plus Aspirin Reduces Venous Thromboembolism in Patients With Chronic Atherosclerosis - Nana Pogosova Jacqueline Bosch Deepak L. Bhatt Keith A.A. Fox Stuart J. Connolly Marco Alings Peter Verhamme Eva Muehlhofer Olga Shestakovska Salim Yusuf John W. Eikelboom National Medical Research Centre of Cardiology, Moscow, Russia (N.P.). Population Health Research Institute, Hamilton, Ontario, Canada (J.P., S.J.C., O.S., S.Y., J.W.E.). McMaster University, Hamilton, Ontario, Canada (J.P., S.J.C., S.Y., J.W.E.). Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, (D.L.B.). Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (K.A.A.F.). Hamilton (...) Circulation
  Circulation, Volume 145, Issue 25, Page 1875-1877, June 21, 2022. (Circulation)
• 10:24
  First Pig-to-Human Heart Transplant Marks a Milestone in Xenotransplantation - Bridget M. Kuehn Circulation
  Circulation, Volume 145, Issue 25, Page 1870-1871, June 21, 2022. (Circulation)
• 10:24
  Allograft Rejection Surveillance In Heart Transplantation: Is There a Better Way? - James C. Fang Omar Wever-Pinzon University of Utah Health Sciences Center, Salt Lake City. Circulation
  Circulation, Volume 145, Issue 25, Page 1825-1828, June 21, 2022. (Circulation)
• 10:24
  Can Early Ablation of Ventricular Tachycardia Improve Survival? - Arvindh N. Kanagasundram Travis D. Richardson William G. Stevenson Cardiovascular Division, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN. Circulation
  Circulation, Volume 145, Issue 25, Page 1850-1852, June 21, 2022. (Circulation)

20 June

Circulation http://ahajournals.org/

• 11:00
  Cerebral Microbleeds During Transcatheter Aortic Valve Replacement: A Prospective Magnetic Resonance Imaging Cohort - Eric Van Belle Nicolas Debry Flavien Vincent Grégory Kuchcinski Charlotte Cordonnier Antoine Rauch Emmanuel Robin Fanny Lassalle François Pontana Cédric Delhaye Guillaume Schurtz Emmanuelle JeanPierre Natacha Rousse Caterina Casari Hugues Spillemaeker Sina Porouchani Thibault Pamart Tom Denimal Xavier Neiger Basile Verdier Laurent Puy Alessandro Cosenza Francis Juthier Marjorie Richardson Martin Bretzner Jean Dallongeville Julien Labreuche Mikael Mazighi Annabelle Dupont-Prado Bart Staels Peter J. Lenting Sophie Susen Cardiology Department (E.V.B., N.D., F.V., C.D., G.S., H.S., S.P., T.P., (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Cerebral microbleeds (CMBs) have been observed in healthy elderly people undergoing systematic brain magnetic resonance imaging. The potential role of acute triggers on the appearance of CMBs remains unknown. We aimed to describe the incidence of new CMBs (...) (Circulation)

17 June

Circulation http://ahajournals.org/

• 11:00
  Frequency of Screening-Detected Intracranial Aneurysms in Patients With Loeys-Dietz Syndrome - Anna L. Huguenard Gabrielle W. Johnson Joshua W. Osbun Ralph G. Dacey Alan C. Braverman Department of Neurosurgery (A.L.H., G.W.J., J.W.O., R.G.D.), Washington University School of Medicine, St. Louis, MO. Department of Medicine, Cardiovascular Division (A.C.B.), Washington University School of Medicine, St. Louis, MO. Circulation
  Circulation, Volume 146, Issue 2, Page 142-143, July 12, 2022. (Circulation)

16 June

Circulation http://ahajournals.org/

• 11:00
  Frequency, Penetrance, and Variable Expressivity of Dilated Cardiomyopathy–Associated Putative Pathogenic Gene Variants in UK Biobank Participants - Ravi A. Shah Babken Asatryan Ghaith Sharaf Dabbagh Nay Aung Mohammed Y. Khanji Luis R. Lopes Stefan van Duijvenboden Anthony Holmes Daniele Muser Andrew P. Landstrom Aaron Mark Lee Pankaj Arora Christopher Semsarian Virend K. Somers Anjali T. Owens Patricia B. Munroe Steffen E. Petersen C. Anwar A. Chahal Imperial College Healthcare NHS Trust, London, United Kingdom (R.A.S.). Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (B.A.). Center for Inherited Cardiovascular Diseases, WellSpan Health, Lancaster, PA (G.S.D., C.A.A.C.). University of (...) Circulation
  Circulation, Volume 146, Issue 2, Page 110-124, July 12, 2022. Background:There is a paucity of data regarding the phenotype of dilated cardiomyopathy (DCM) gene variants in the general population. We aimed to determine the frequency and penetrance of DCM-associated putative pathogenic gene (...) (Circulation)

14 June

Circulation http://ahajournals.org/

• 09:00
  Correction to: Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity Circulation
  Circulation, Volume 146, Issue 1, Page e3-e3, July 5, 2022. (Circulation)

13 June

Circulation http://ahajournals.org/

• 11:00
  Differences in Comorbidities Explain Black–White Disparities in Outcomes After Femoropopliteal Endovascular Intervention - Anna K. Krawisz Sahana Natesan Rishi K. Wadhera Siyan Chen Yang Song Robert W. Yeh Michael R. Jaff Jay Giri Howard Julien Eric A. Secemsky Department of Medicine, Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology (A.K.K., S.N., R.K.W., S.C., Y.S., R.W.Y., E.A.S.), Beth Israel Deaconess Medical Center, Boston, MA. Department of Medicine, Division of Cardiology (A.K.K., R.K.W., R.W.Y., E.A.S.), Beth Israel Deaconess Medical Center, Boston, MA. Harvard Medical School, Boston, MA (A.K.K., R.K.W., R.W.Y., M.R.J., E.A.S.). Penn Cardiovascular Outcomes, Quality, & (...) Circulation
  Circulation, Volume 146, Issue 3, Page 191-200, July 19, 2022. Background:Black adults have a higher incidence of peripheral artery disease and limb amputations than White adults in the United States. Given that peripheral endovascular intervention (PVI) is now the primary revascularization (...) (Circulation)
• 08:00
  Premature Complexes and Blocked P Wave - Ethan Morgan John Anderson Amit Noheria Department of Internal Medicine (E.M.), University of Kansas Medical Center, Kansas City. Department of Cardiovascular Medicine (J.A., A.N.), University of Kansas Medical Center, Kansas City. Circulation
  Circulation, Volume 145, Issue 24, Page 1803-1805, June 14, 2022. (Circulation)
• 08:00
  Higher Incidence of Chromosomal Aberrations in Operators Performing a Large Volume of Endovascular Procedures - Mohamed A. Abdelhalim Ashish Patel Jayne Moquet Prakash Saha Alberto Smith Christophe Badie Rhona Anderson Elizabeth Ainsbury Bijan Modarai Academic Department of Vascular Surgery, School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, British Heart Foundation Centre of Research Excellence and Guy’s and St. Thomas’ National Health Service Foundation Trust Biomedical Research Centre, United Kingdom (M.A.A., A.P., P.S., A.S., B.M.). United Kingdom Health Security Agency Centre for Radiation, Chemical and Environmental Threats and Hazards, Chilton, United Kingdom (...) Circulation
  Circulation, Volume 145, Issue 24, Page 1808-1810, June 14, 2022. (Circulation)
• 08:00
  What Does the American Heart Association Do (and How Can You Help)? - Donald M. Lloyd-Jones Departments of Preventive Medicine, Medicine, and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL. Circulation
  Circulation, Volume 145, Issue 24, Page e1073-e1076, June 14, 2022. (Circulation)
• 08:00
  From the Literature - Tracy Hampton Circulation
  Circulation, Volume 145, Issue 24, Page 1806-1807, June 14, 2022. (Circulation)
• 08:00
  Environmental Triggers of Acute Coronary Syndromes - Nicholas L. Mills C. Arden Pope BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (N.L.M.). Usher Institute, University of Edinburgh, United Kingdom (N.L.M.). Brigham Young University, Provo, UT (C.A.P.). Circulation
  Circulation, Volume 145, Issue 24, Page 1761-1763, June 14, 2022. (Circulation)
• 08:00
  Expanding the Therapeutic World of Tryptophan Metabolism - Gregory A. Wyant Javid Moslehi Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (G.A.W.). Howard Hughes Medical Institute, Chevy Chase, MD (G.A.W.). Section of Cardio-Oncology and Immunology, Division of Cardiology and the Cardiovascular Research Institute, University of California San Francisco (J.M.). Circulation
  Circulation, Volume 145, Issue 24, Page 1799-1802, June 14, 2022. (Circulation)
• 08:00
  At the Crossroad Between Skeletal and Cardiac Muscle Cells - Christopher R. deFilippi Abdulla A. Damluji From the Inova Heart and Vascular Institute, Falls Church, VA (C.R.d.F., A.A.D.). Johns Hopkins University School of Medicine, Baltimore, MD (A.A.D.). Circulation
  Circulation, Volume 145, Issue 24, Page 1780-1783, June 14, 2022. (Circulation)

9 June

Circulation http://ahajournals.org/

• 11:00
  Association of Neighborhood-Level Material Deprivation With Atrial Fibrillation Care in a Single-Payer Health Care System: A Population-Based Cohort Study - Husam Abdel-Qadir Leo E. Akioyamen Jiming Fang Andrea Pang Andrew C.T. Ha Cynthia A. Jackevicius David A. Alter Peter C. Austin Clare L. Atzema R. Sacha Bhatia Gillian L. Booth Sharon Johnston Irfan Dhalla Moira K. Kapral Harlan M. Krumholz Candace D. McNaughton Idan Roifman Karen Tu Jacob A. Udell Harindra C. Wijeysundera Dennis T. Ko Michael J. Schull Douglas S. Lee Women’s College Hospital, Toronto, Canada (H.A.-Q., J.A.U.). University Health Network, Toronto, Canada (H.A.-Q., A.C.T.H., C.A.J., D.A.A., R.S.B., M.K.K., K.T., J.A.U., D.S.L.). ICES (formerly known as the Institute for (...) Circulation
  Circulation, Volume 146, Issue 3, Page 159-171, July 19, 2022. Background:There are limited data on the association of material deprivation with clinical care and outcomes after atrial fibrillation (AF) diagnosis in jurisdictions with universal health care.Methods:This was a population-based (...) (Circulation)
• 03:56
  Left-Sided Degenerative Valvular Heart Disease in Type 1 and Type 2 Diabetes - Araz Rawshani Naveed Sattar Darren K. McGuire Oskar Wallström Ulf Smith Jan Borén Göran Bergström Elmir Omerovic Annika Rosengren Björn Eliasson Deepak L. Bhatt Aidin Rawshani Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sweden; Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, University of Gothenburg, Sweden Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, Glasgow, UK Department of Internal Medicine, University of Texas Southwestern (...) Circulation
  Circulation, Ahead of Print. Background: The role of diabetes in the development of valvular heart disease and particularly the relation with risk factor control, has not been extensively studied.Methods: We included 715,143 patients with diabetes registered in the Swedish National Diabetes (...) (Circulation)

6 June

Circulation http://ahajournals.org/

• 08:00
  Single Nucleus Transcriptomics: Apical Resection in Newborn Pigs Extends the Time Window of Cardiomyocyte Proliferation and Myocardial Regeneration - Yuji Nakada Yang Zhou Wuming Gong Eric Y. Zhang Erik Skie Thanh Nguyen Yuhua Wei Meng Zhao Wangping Chen Jiacheng Sun S. Naqi Raza Jake Y. Chen Gregory P. Walcott Daniel J. Garry Jianyi (Jay) Zhang Department of Biomedical Engineering (Y.N., Y.Z., E.Y.Z., Y.W., M.Z., W.C., J.S., S.N.R., J.Z.), University of Alabama at Birmingham. Informatics Institute (T.N., J.Y.C.), University of Alabama at Birmingham. Department of Medicine, Cardiovascular Disease (G.P.W., J.Z.), University of Alabama at Birmingham. Department of Medicine, School of Medicine, University of Minnesota, Minneapolis (W.G., (...) Circulation
  Circulation, Volume 145, Issue 23, Page 1744-1747, June 7, 2022. (Circulation)
• 08:00
  Evidence Builds for Catheter Ablation for Atrial Fibrillation and Heart Failure - Sean D. Pokorney Christopher B. Granger Duke Clinical Research Institute and the Division of Cardiology, Duke University School of Medicine, Durham, NC. Circulation
  Circulation, Volume 145, Issue 23, Page 1705-1707, June 7, 2022. (Circulation)
• 08:00
  Histone Acetyltransferases in Smooth Muscle Cell Phenotype Switching: Redundant No Longer - Iris Z. Jaffe Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA. Circulation
  Circulation, Volume 145, Issue 23, Page 1738-1740, June 7, 2022. (Circulation)

3 June

Circulation http://ahajournals.org/

• 11:01
  Endovascular Treatment Versus Best Medical Management in Acute Basilar Artery Occlusion Strokes: Results From the ATTENTION Multicenter Registry - Chunrong Tao Adnan I. Qureshi Yamei Yin Jie Li Rui Li Pengfei Xu Jun Sun Geng Liao Xincan Yue Hongchao Shi Yongchang Liu Zhengfei Ma Jinhua Zhang Guodong Xiao Bo Xu Chenghua Xu Junfeng Su Wensheng Zhou Shuchun Huang Weimin Yang Hongbing Chen Wei Li Yongkun Li Dezhi Liu Chuanqing Yu Guangxiong Yuan Chaobin Wang Wenbao Liang Chun Chen Xueying Shi Junjun Wang Yingchun Wu Xueli Cai Chunyun Shen Kai Li Pu Fang Ming Wang Zhongjun Chen Tong Li Guangsen Cheng Yaxuan Sun Yan Wang Hui Zhang Jie Chen Xiaohui Xu Youmeng Wang Wanjie Geng Chuyuan Ni Changchun Chen Yan Liu Jie Min Yongcheng Zhang Yong (...) Circulation
  Circulation, Volume 146, Issue 1, Page 6-17, July 5, 2022. Background:The authors compare the effectiveness and safety of endovascular treatment (EVT) versus best medical management (BMM) in strokes attributable to acute basilar artery occlusion (BAO).Methods:The present analysis was based on (...) (Circulation)
• 11:00
  Pregnancy and Spontaneous Coronary Artery Dissection: Lessons From Survivors and Nonsurvivors - Nathan Chan Diluka Premawardhana Abtehale Al-Hussaini Alice Wood Vasiliki Bountziouka Deevia Kotecha Eva Swahn Henning Palmefors Christos Pagonis Sofia Sederholm Lawesson Jacek K?dziela Marcos Garcia-Guimarães Fernando Alfonso Javier Escaned Fernando Macaya Melisa Santás Enrico Cerrato Angela H.E.M. Maas Ota Hlinomaz Nigussie Bogale Bernardo Cortese Mavis Cheng Aidan Bolger Shazia T. Hussain Nilesh J. Samani Marian Knight Matthew Cauldwell David Adlam Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, UK (N.C., D.P., A.A., A.W., V.B., D.K., M.C., A.B., (...) Circulation
  Circulation, Volume 146, Issue 1, Page 69-72, July 5, 2022. (Circulation)

2 June

Circulation http://ahajournals.org/

• 11:01
  Association of Cardiovascular Health Through Young Adulthood With Genome-Wide DNA Methylation Patterns in Midlife: The CARDIA Study - Yinan Zheng Brian T. Joyce Shih-Jen Hwang Jiantao Ma Lei Liu Norrina B. Allen Amy E. Krefman Jun Wang Tao Gao Drew R. Nannini Haixiang Zhang David R. Jacobs Myron D. Gross Myriam Fornage Cora E. Lewis Pamela J. Schreiner Stephen Sidney Dongquan Chen Philip Greenland Daniel Levy Lifang Hou Donald M. Lloyd-Jones Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Z., B.T.J., N.B.A., A.E.K., J.W., T.G., D.R.N., P.G., L.H., D.M.L.-J.). Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, (...) Circulation
  Circulation, Volume 146, Issue 2, Page 94-109, July 12, 2022. Background:Cardiovascular health (CVH) from young adulthood is strongly associated with an individual’s future risk of cardiovascular disease (CVD) and total mortality. Defining epigenomic biomarkers of lifelong CVH exposure and (...) (Circulation)
• 11:00
  hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration - Jisheng Sun Elizabeth A. Peterson Annabel Z. Wang Jianhong Ou Kieko E. Smith Kenneth D. Poss Jinhu Wang Division of Cardiology, School of Medicine, Emory University, Atlanta, GA (J.S., E.A.P., K.E.S., J.W.). Duke Regeneration Center, Department of Cell Biology, Duke University Medical Center, Durham, NC (A.Z.W., J.O., K.D.P.). Circulation
  Circulation, Volume 146, Issue 1, Page 48-63, July 5, 2022. Background:Certain nonmammalian species such as zebrafish have an elevated capacity for innate heart regeneration. Understanding how heart regeneration occurs in these contexts can help illuminate cellular and molecular events that can (...) (Circulation)

31 May

Circulation http://ahajournals.org/

• 08:00
  “The Doctor Is Out”: New Tactics and Soldiers for Our Losing Battle Against Hypertension - Robert D. Brook Benjamin M. Scirica Phillip D. Levy Division of Cardiovascular Diseases, Department of Internal Medicine (R.D.B.), Wayne State University, Detroit, MI. Department of Emergency Medicine and Integrative Biosciences Center (P.D.L.), Wayne State University, Detroit, MI. Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (B.M.S.). Circulation
  Circulation, Volume 145, Issue 22, Page 1629-1631, May 31, 2022. (Circulation)
• 08:00
  Shouldn’t Preventing Type 2 Diabetes Also Prevent Its Long-Term Consequences? - Hertzel C. Gerstein Population Health Research Institute, McMaster University and Hamilton Health Sciences, Canada. Circulation
  Circulation, Volume 145, Issue 22, Page 1642-1644, May 31, 2022. (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 145, Issue 22, Page 1684-1689, May 31, 2022. (Circulation)

27 May

Circulation http://ahajournals.org/

• 14:00
  Cardiovascular Magnetic Resonance for Rejection Surveillance After Cardiac Transplantation - Chris Anthony Muhammad Imran Jim Pouliopoulos Sam Emmanuel James Iliff Zhixin Liu Kirsten Moffat Min Ru Qiu Catriona A. McLean Christian Stehning Valentina Puntmann Vass Vassiliou Tevfik F. Ismail Ankur Gulati Sanjay Prasad Robert M. Graham Jane McCrohon Cameron Holloway Eugene Kotlyar Kavitha Muthiah Anne M. Keogh Christopher S. Hayward Peter S. Macdonald Andrew Jabbour Heart and Lung Transplant Unit (C.A., M.I., J.P., S.E., J.I., M.R.Q., R.M.G., J.M., C.H., E.K., K.M., A.M.K., C.S.H., P.S.M., A.J.), St. Vincent’s Hospital, Sydney, Australia. Medical Imaging Department (K.M.), St. (...) Circulation
  Circulation, Volume 145, Issue 25, Page 1811-1824, June 21, 2022. Background:Endomyocardial biopsy (EMB) is the gold standard method for surveillance of acute cardiac allograft rejection (ACAR) despite its invasive nature. Cardiovascular magnetic resonance (CMR)–based myocardial tissue (...) (Circulation)

26 May

Circulation http://ahajournals.org/

• 11:01
  Prolonged Myocardial Regenerative Capacity in Neonatal Opossum - Chihiro Nishiyama Yuichi Saito Akane Sakaguchi Mari Kaneko Hiroshi Kiyonari Yuqing Xu Yuichiro Arima Hideki Uosaki Wataru Kimura Laboratory for Heart Regeneration (C.N., Y.S., A.S., W.K.), RIKEN Center for Biosystems Dynamics Research, Kobe, Japan. Laboratory for Animal Resources and Genetic Engineering (M.K., H.K.), RIKEN Center for Biosystems Dynamics Research, Kobe, Japan. Laboratory for Developmental Cardiology, International Research Center for Medical Science, Kumamoto University, Japan (Y.X., Y.A.). Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical (...) Circulation
  Circulation, Volume 146, Issue 2, Page 125-139, July 12, 2022. Background:Early neonates of both large and small mammals are able to regenerate the myocardium through cardiomyocyte proliferation for only a short period after birth. This myocardial regenerative capacity declines in parallel with (...) (Circulation)
• 11:00
  Frailty Status Modifies the Efficacy of Exercise Training Among Patients With Chronic Heart Failure and Reduced Ejection Fraction: An Analysis From the HF-ACTION Trial - Ambarish Pandey Matthew W. Segar Sumitabh Singh Gordon R. Reeves Christopher O’Connor Ileana Piña David Whellan William E. Kraus Robert J. Mentz Dalane W. Kitzman Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (A.P., S.S.). Department of Cardiology, Texas Heart Institute, Houston (M.W.S.). Cardiovascular Disease, Heart Failure and Transplant, Novant Health, Charlotte, NC (G.R.). Inova Heart and Vascular Institute, Falls Church, VA (C.O.). Wayne State University, Detroit, MI (I.P.). Division of Cardiology, Department of (...) Circulation
  Circulation, Volume 146, Issue 2, Page 80-90, July 12, 2022. Background:Supervised aerobic exercise training (ET) is recommended for stable outpatients with heart failure (HF) with reduced ejection fraction (HFrEF). Frailty, a syndrome characterized by increased vulnerability and decreased (...) (Circulation)
• 11:00
  Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity - Mahmoud Abdellatif Viktoria Trummer-Herbst Alexander Martin Heberle Alina Humnig Tobias Pendl Sylvère Durand Giulia Cerrato Sebastian J. Hofer Moydul Islam Julia Voglhuber José Miguel Ramos Pittol Oliver Kepp Gerald Hoefler Albrecht Schmidt Peter P. Rainer Daniel Scherr Dirk von Lewinski Egbert Bisping Julie R. McMullen Abhinav Diwan Tobias Eisenberg Frank Madeo Kathrin Thedieck Guido Kroemer Simon Sedej Department of Cardiology (M.A., V.T.-H., A.H., J.V., A.S., P.P.R., D.S., D.v.L. E.B., S.S.), Medical University of Graz, Austria. Diagnostic and Research Center for Molecular BioMedicine, (...) Circulation
  Circulation, Volume 145, Issue 25, Page 1853-1866, June 21, 2022. Background:The insulin-like growth factor 1 (IGF1) pathway is a key regulator of cellular metabolism and aging. Although its inhibition promotes longevity across species, the effect of attenuated IGF1 signaling on cardiac aging (...) (Circulation)

24 May

Circulation http://ahajournals.org/

• 11:00
  Associations of Clinical and Social Risk Factors With Racial Differences in Premature Cardiovascular Disease - Nilay S. Shah Hongyan Ning Lucia C. Petito Kiarri N. Kershaw Michael P. Bancks Jared P. Reis Jamal S. Rana Stephen Sidney David R. Jacobs Catarina I. Kiefe Mercedes R. Carnethon Donald M. Lloyd-Jones Norrina B. Allen Sadiya S. Khan Department of Preventive Medicine (N.S.S., H.N., L.C.P., K.N.K., M.R.C., D.M.L.-J., N.B.A., S.S.K.), Northwestern University Feinberg School of Medicine, Chicago, IL. Division of Cardiology, Department of Medicine (N.S.S., D.M.L.-J., S.S.K.), Northwestern University Feinberg School of Medicine, Chicago, IL. Department of Epidemiology and Prevention, Wake Forest (...) Circulation
  Circulation, Volume 146, Issue 3, Page 201-210, July 19, 2022. Background:Racial differences in cardiovascular disease (CVD) are likely related to differences in clinical and social factors. The relative contributions of these factors to Black-White differences in premature CVD have not been (...) (Circulation)

23 May

Circulation http://ahajournals.org/

• 10:55
  Metabolomic Profiling of the Effects of Dapagliflozin in Heart Failure with Reduced Ejection Fraction: DEFINE-HF - Senthil Selvaraj Zhuxuan Fu Philip Jones Lydia C. Kwee Sheryl L. Windsor Olga Ilkayeva Christopher B. Newgard Kenneth B. Margulies Mansoor Husain Silvio E. Inzucchi Darren K. McGuire Bertram Pitt Benjamin M. Scirica David E. Lanfear Michael E. Nassif Ali Javaheri Robert J. Mentz Mikhail N. Kosiborod Svati H. Shah Division of Cardiology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA Saint Luke's Mid America Heart Institute, Kansas City, MO Duke Molecular Physiology Institute, Durham, NC Duke Molecular Physiology Institute, Durham, NC; Division of (...) Circulation
  Circulation, Ahead of Print. Background:Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are foundational therapy in patients with heart failure with reduced ejection fraction (HFrEF), yet underlying mechanisms of benefit are not well defined. We sought to investigate the relationships (...) (Circulation)
• 11:15
  Estimating the Benefits of Combination Medical Therapy in Heart Failure With Mildly Reduced and Preserved Ejection Fraction - Muthiah Vaduganathan Brian L. Claggett Riccardo M. Inciardi Gregg C. Fonarow John J.V. McMurray Scott D. Solomon Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (M.V., B.L.C., S.D.S.). Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Italy (R.M.I.). Ahmanson-UCLA Cardiomyopathy Center, University of California, Los Angeles (G.C.F.). British Heart Foundation Cardiovascular Research Centre, University of Glasgow, UK (...) Circulation
  Circulation, Volume 145, Issue 23, Page 1741-1743, June 7, 2022. (Circulation)
• 11:00
  Effects of Long-term Metformin and Lifestyle Interventions on Cardiovascular Events in the Diabetes Prevention Program and Its Outcome Study - Ronald B. Goldberg Trevor J. Orchard Jill P. Crandall Edward J. Boyko Matthew Budoff Dana Dabelea Kishore M. Gadde William C. Knowler Christine G. Lee David M. Nathan Karol Watson Marinella Temprosa University of Miami Miller School of Medicine, FL (R.B.G.). University of Pittsburgh Graduate School of Public Health, PA (T.J.O.). Albert Einstein College of Medicine, Bronx, NY (J.P.C.). VA Puget Sound Health Care System, Seattle, WA (E.J.B.). Los Angeles Biomedical Research Institute, Torrance, CA (M.B.). University of Colorado Anschutz Medical Campus, Aurora (D.D.). Pennington Biomedical (...) Circulation
  Circulation, Volume 145, Issue 22, Page 1632-1641, May 31, 2022. Background:Lifestyle intervention and metformin have been shown to prevent diabetes; however, their efficacy in preventing cardiovascular disease associated with the development of diabetes is unclear. We examined whether these (...) (Circulation)
• 08:00
  2022 Beijing Winter Olympics: Spotlight on Cardiac Metabolism - Heinrich Taegtmeyer Vlad G. Zaha Darren K. McGuire Department of Internal Medicine, Division of Cardiology, McGovern Medical School at The University of Texas Health Science Center at Houston (H.T.). Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX (V.G.Z., D.K.M.). Parkland Health and Hospital System, Dallas, TX (V.G.Z., D.K.M.). Cardio-Oncology Program, Harold C. Simmons Comprehensive Cancer Center, Dallas, TX (...) Circulation
  Circulation, Volume 145, Issue 21, Page 1561-1562, May 24, 2022. (Circulation)
• 08:00
  Letter by Maqsood et al Regarding Article, “Anterior–Lateral Versus Anterior–Posterior Electrode Position for Cardioverting Atrial Fibrillation” - Naima Maqsood Joshua M. Cooper Isaac R. Whitman Department of Medicine (N.M.) Lewis Katz School of Medicine at the Temple University Hospital, Philadelphia, PA. Section of Cardiac Electrophysiology, Temple Heart and Vascular Institute (J.M.C., I.R.W), Lewis Katz School of Medicine at the Temple University Hospital, Philadelphia, PA. Circulation
  Circulation, Volume 145, Issue 21, Page e1054-e1055, May 24, 2022. (Circulation)
• 08:00
  Letter by Ibrahim et al Regarding Article, “Anterior–Lateral Versus Anterior–Posterior Electrode Position for Cardioverting Atrial Fibrillation” - Omar Ahmad Ibrahim Emilie P. Belley-Côté William F. McIntyre McMaster University, Hamilton, Ontario, Canada (O.A.I., E.P.B.-C.). Population Health Research Institute, Cleveland, OH (W.F.M.). Circulation
  Circulation, Volume 145, Issue 21, Page e1056-e1056, May 24, 2022. (Circulation)
• 08:00
  Response to Letters Regarding Article, “Anterior–Lateral Versus Anterior–Posterior Electrode Position for Cardioverting Atrial Fibrillation” - Anders S. Schmidt Kasper G. Lauridsen Andi E. Albertsen Bo Løfgren Department of Internal Medicine, Randers Regional Hospital, Denmark (A.S.S., K.G.L., B.L.). Research Center for Emergency Medicine, Aarhus University Hospital, Denmark (A.S.S., K.G.L., B.L.). Department of Cardiology, Viborg Regional Hospital, Denmark (A.E.A.). Department of Clinical Medicine, Aarhus University, Denmark (B.L.). Circulation
  Circulation, Volume 145, Issue 21, Page e1057-e1058, May 24, 2022. (Circulation)
• 08:00
  Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure - Andrew A. Gibb Emma K. Murray Anh T. Huynh Ryan B. Gaspar Tori L. Ploesch Ken Bedi Alyssa A. Lombardi Pawel K. Lorkiewicz Rajika Roy Zolt Arany Daniel P. Kelly Kenneth B. Margulies Bradford G. Hill John W. Elrod Center for Translational Medicine, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (A.A.G., E.K.M., A.T.H., R.B.G., T.L.P., A.A.L., R.R., J.W.E.). Department of Chemistry (P.K.L.), University of Louisville, KY. Division of Environmental Medicine (B.G.H.), University of Louisville, KY. Cardiovascular Institute and (...) Circulation
  Circulation, Volume 145, Issue 21, Page 1625-1628, May 24, 2022. (Circulation)
• 08:00
  Seeing Old Landscapes With New Eyes: A Voyage Into the Endomyocardial Biopsy to Improve Risk Stratification After Heart Transplant Using Computational Analysis - Guillaume Coutance Jignesh K. Patel Department of Cardiac and Thoracic Surgery, Cardiology Institute, Pitié Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Sorbonne University Medical School, France (G.C.). University of Paris, INSERM UMR 970, Paris Translational Research Centre for Organ Transplantation, France (G.C.). Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (J.K.P.). Circulation
  Circulation, Volume 145, Issue 21, Page 1578-1580, May 24, 2022. (Circulation)
• 08:00
  Atrial Shunt Devices in Patients With Heart Failure and Preserved or Mildly Reduced Ejection Fraction and the Pulmonary Circulation: Promises and Concerns - Alexandra Saunders Evangelos Michelakis Department of Medicine (Cardiology), University of Alberta Hospital, Edmonton, AB, Canada (A.S., E.M.). Circulation
  Circulation, Volume 145, Issue 21, Page 1605-1608, May 24, 2022. (Circulation)

21 May

Circulation http://ahajournals.org/

• 11:15
  Health Status Trajectories Before and After Hospitalization for Heart Failure - Muthiah Vaduganathan Brian L. Claggett John J.V. McMurray Scott D. Solomon Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (M.V., B.L.C., S.D.S.). British Heart Foundation Cardiovascular Research Centre, University of Glasgow, UK (J.J.V.M.). Circulation
  Circulation, Volume 145, Issue 25, Page 1872-1874, June 21, 2022. (Circulation)

20 May

Circulation http://ahajournals.org/

• 04:00
  Correction to: Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity Circulation
  Circulation, Volume 145, Issue 23, Page e1072-e1072, June 7, 2022. (Circulation)

18 May

Circulation http://ahajournals.org/

• 11:00
  Indoleamine 2,3-Dioxygenase 1 Deletion–Mediated Kynurenine Insufficiency in Vascular Smooth Muscle Cells Exacerbates Arterial Calcification - Liu Ouyang Changjiang Yu Zhiyong Xie Xiaoyan Su Zengmei Xu Ping Song Jian Li Hui Huang Ye Ding Ming-Hui Zou Center for Molecular and Translational Medicine, Georgia State University, Atlanta (L.Q., C.Y., P.S., J.L., Y.D., M.H.Z.). School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, China (Z. Xie, Z. Xu). Department of Nephropathy, Tungwah Hospital of Sun Yat-sen University, Dongguan, China (X.S.). Department of Cardiology, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China (...) Circulation
  Circulation, Volume 145, Issue 24, Page 1784-1798, June 14, 2022. Background:IDO1 (indoleamine 2,3-dioxygenase 1) is the rate-limiting enzyme for tryptophan metabolism. IDO1 malfunction is involved in the pathogenesis of atherosclerosis. Vascular smooth muscle cells (VSMCs) with an osteogenic (...) (Circulation)

16 May

Circulation http://ahajournals.org/

• 08:00
  Correction to: Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications Circulation
  Circulation, Volume 145, Issue 20, Page e1053-e1053, May 17, 2022. (Circulation)
• 08:00
  A Role for the Vascular Endothelium in Post–Acute COVID-19? - Laura P.M.H. de Rooij Lisa M. Becker Peter Carmeliet Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, Vlaams Instituut voor Biotechnologie and Department of Oncology, Leuven Cancer Institute, Katholieke Universiteit Leuven, Belgium (L.P.M.H.d.R., L.M.B., P.C.). State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong, China (P.C.). Laboratory of Angiogenesis and Vascular Heterogeneity, Department of Biomedicine, Aarhus University, Denmark (P.C.). Center for Biotechnology, Khalifa University of Science (...) Circulation
  Circulation, Volume 145, Issue 20, Page 1503-1505, May 17, 2022. (Circulation)
• 08:00
  What Eggsactly Are We Asking Here? Unscrambling the Epidemiology of Eggs, Cholesterol, and Mortality - Deirdre K. Tobias Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA. Nutrition Department, Harvard TH Chan School of Public Health, Boston, MA. Circulation
  Circulation, Volume 145, Issue 20, Page 1521-1523, May 17, 2022. (Circulation)

12 May

Circulation http://ahajournals.org/

• 11:00
  Cardiovascular Outcomes in Collegiate Athletes After SARS-CoV-2 Infection: 1-Year Follow-Up From the Outcomes Registry for Cardiac Conditions in Athletes - Bradley J. Petek Nathaniel Moulson Jonathan A. Drezner Kimberly G. Harmon Stephanie A. Kliethermes Timothy W. Churchill Manesh R. Patel Aaron L. Baggish Division of Cardiology (B.J.P., T.W.C., A.L.B.), Massachusetts General Hospital, Boston. Cardiovascular Performance Program (B.J.P., T.W.C., A.L.B.), Massachusetts General Hospital, Boston. Division of Cardiology and Sports Cardiology British Columbia, University of British Columbia, Vancouver, Canada (N.M.). Department of Family Medicine and Center for Sports Cardiology, University of Washington, Seattle (J.A.D., K.G.H.). Department of (...) Circulation
  Circulation, Volume 145, Issue 22, Page 1690-1692, May 31, 2022. (Circulation)

10 May

Circulation http://ahajournals.org/

• 11:00
  Strengthening US Food Policies and Programs to Promote Equity in Nutrition Security: A Policy Statement From the American Heart Association - Anne N. Thorndike Christopher D. Gardner Katherine Bishop Kendrick Hilary K. Seligman Amy L. Yaroch Aldrin V. Gomes Kendra N. Ivy Stephanie Scarmo Caree Jackson Cotwright Marlene B. Schwartz Circulation
  Circulation, Volume 145, Issue 24, Page e1077-e1093, June 14, 2022. Nutritionally inadequate dietary intake is a leading contributor to chronic cardiometabolic diseases. Differences in dietary quality contribute to socioeconomic and racial and ethnic health disparities. Food insecurity, a (...) (Circulation)
• 11:01
  Rapid Exclusion of Acute Myocardial Injury and Infarction With a Single High-Sensitivity Cardiac Troponin T in the Emergency Department: A Multicenter United States Evaluation - Yader Sandoval Bradley R. Lewis Ramila A. Mehta Olatunde Ola Jonathan D. Knott Laura De Michieli Ashok Akula Ronstan Lobo Eric H. Yang S. Michael Gharacholou Marshall Dworak Erika Crockford Nicholas Rastas Eric Grube Swetha Karturi Scott Wohlrab David O. Hodge Tahir Tak Charles Cagin Rajiv Gulati Allan S. Jaffe Department of Cardiovascular Diseases (Y.L., L.D.M., R.L., R.G., A.S.J.), Mayo Clinic, Rochester, MN. Division of Biomedical Statistics and Informatics (B.R.L.), Mayo Clinic, Rochester, MN. Department of Internal Medicine (J.D.K.), Mayo Clinic, Rochester, MN. Department of (...) Circulation
  Circulation, Volume 145, Issue 23, Page 1708-1719, June 7, 2022. Background:There are good data to support using a single high-sensitivity cardiac troponin T (hs-cTnT) below the limit of detection of 5 ng/L to exclude acute myocardial infarction. Per the US Food and Drug Administration, hs-cTnT (...) (Circulation)

9 May

Circulation http://ahajournals.org/

• 06:55
  rECHOmmend: An ECG-Based Machine Learning Approach for Identifying Patients at Increased Risk of Undiagnosed Structural Heart Disease Detectable by Echocardiography - Alvaro E. Ulloa-Cerna Linyuan Jing John M. Pfeifer Sushravya Raghunath Jeffrey A. Ruhl Daniel B. Rocha Joseph B. Leader Noah Zimmerman Greg Lee Steven R. Steinhubl Christopher W. Good Christopher M. Haggerty Brandon K. Fornwalt Ruijun Chen Department of Translational Data Science and Informatics (A.E.U-C., L.J., J.M.P., S.R., J.A.R., C.W.G., C.M.H., B.K.F., R.C.); Geisinger, Danville, PA. Phenomic Analytics and Clinical Data Core (D.B.R., J.B.L.); Geisinger, Danville, PA. Department of Radiology (B.K.F.); Geisinger, Danville, PA. Department of Medicine (R.C.); Geisinger, Danville, PA. (...) Circulation
  Circulation, Volume 146, Issue 1, Page 36-47, July 5, 2022. Background:Timely diagnosis of structural heart disease improves patient outcomes, yet many remain underdiagnosed. While population screening with echocardiography is impractical, ECG-based prediction models can help target high-risk (...) (Circulation)
• 11:00
  Call to Action for Cardiovascular Disease in Women: Epidemiology, Awareness, Access, and Delivery of Equitable Health Care: A Presidential Advisory From the American Heart Association - Nanette K. Wenger Donald M. Lloyd-Jones Mitchell S.V. Elkind Gregg C. Fonarow John J. Warner Heather M. Alger Susan Cheng Claire Kinzy Jennifer L. Hall Véronique L. Roger Circulation
  Circulation, Volume 145, Issue 23, Page e1059-e1071, June 7, 2022. Addressing the pervasive gaps in knowledge and care delivery to reduce sex-based disparities and achieve equity is fundamental to the American Heart Association’s commitment to advancing cardiovascular health for all by 2024. (...) (Circulation)
• 08:00
  From the Literature - Tracy Hampton Circulation
  Circulation, Volume 145, Issue 19, Page 1497-1498, May 10, 2022. (Circulation)
• 08:00
  Text Messages to Improve Medication Adherence and Secondary Prevention After Acute Coronary Syndrome: The TEXTMEDS Randomized Clinical Trial - Clara K. Chow Harry Klimis Aravinda Thiagalingam Julie Redfern Graham S. Hillis David Brieger John Atherton Ravinay Bhindi Derek P. Chew Nicholas Collins Michael Andrew Fitzpatrick Craig Juergens Nadarajah Kangaharan Andrew Maiorana Michele McGrady Rohan Poulter Pratap Shetty Jonathon Waites Christian Hamilton Craig Peter Thompson Sandrine Stepien Amy Von Huben Anthony Rodgers Westmead Applied Research Institute (C.K.C., H.K., A.T., A.V.H., A.R.), University of Sydney, Australia. Faculty of Medicine and Health (J.R., R.B., M.A.F., M.M.), University of Sydney, Australia. ANZAC Research (...) Circulation
  Circulation, Volume 145, Issue 19, Page 1443-1455, May 10, 2022. Background:TEXTMEDS (Text Messages to Improve Medication Adherence and Secondary Prevention After Acute Coronary Syndrome) examined the effects of text message–delivered cardiac education and support on medication adherence after (...) (Circulation)
• 08:00
  Letter by Ren and Yang Regarding Article, “Retention of the NLRP3 Inflammasome–Primed Neutrophils in the Bone Marrow Is Essential for Myocardial Infarction–Induced Granulopoiesis” - Chuanli Ren Zhangjun Yang Department of Laboratory Medicine, Clinical Medical College of Yangzhou University, China (C.R.). Department of Chemistry, Yangzhou University, China (Z.Y.). Circulation
  Circulation, Volume 145, Issue 19, Page e1034-e1034, May 10, 2022. (Circulation)
• 08:00
  Response by Nagareddy and Sreejit to Letter Regarding Article, “Retention of the NLRP3 Inflammasome-Primed Neutrophils in the Bone Marrow Is Essential for Myocardial Infarction–Induced Granulopoiesis” - Prabhakara R. Nagareddy Gopalkrishna Sreejit Division of Cardiac Surgery, Department of Surgery, Ohio State University Wexner Medical Center, Columbus. Circulation
  Circulation, Volume 145, Issue 19, Page e1035-e1036, May 10, 2022. (Circulation)
• 08:00
  Circulation Best Papers 2021 - Joseph A. Hill Darren K. McGuire James A. de Lemos Department of Medicine (Cardiology) (J.A.H., D.K.M., J.A.d.L.), UT Southwestern Medical Center, Dallas. Department of Molecular Biology (J.A.H.), UT Southwestern Medical Center, Dallas. Parkland Health and Hospital System, Dallas, TX (D.K.M.). Circulation
  Circulation, Volume 145, Issue 19, Page 1441-1442, May 10, 2022. (Circulation)
• 08:00
  Opportunities and Challenges of Mobile Health Tools to Promote Health Behaviors - Abhinav Sharma Robert Avram DREAM-CV Lab, McGill University Health Centre, Montreal, QC, Canada (A.S.). Division of Cardiology, Department of Medicine, McGill University, Montreal, QC, Canada (A.S.). Division of Cardiology, Department of Medicine, Montreal Heart Institute, University of Montreal, QC, Canada (R.A.). Circulation
  Circulation, Volume 145, Issue 19, Page 1456-1459, May 10, 2022. (Circulation)

6 May

Circulation http://ahajournals.org/

• 11:00
  E-Cigarette Use and Risk of Cardiovascular Disease: A Longitudinal Analysis of the PATH Study (2013–2019) - Jonathan B. Berlowitz Wubin Xie Alyssa F. Harlow Naomi M. Hamburg Michael J. Blaha Aruni Bhatnagar Emelia J. Benjamin Andrew C. Stokes Departments of Global Health (J.B.B., W.X., A.C.S.), Boston University School of Public Health, MA. Epidemiology (E.J.B.), Boston University School of Public Health, MA. University of Southern California Keck School of Medicine, Department of Population and Public Health Sciences, Los Angeles (A.F.H.). Department of Medicine, Boston University School of Medicine, MA (N.M.H., E.J.B.). Ciccarone Center for the Prevention of Cardiovascular Disease, Johns (...) Circulation
  Circulation, Volume 145, Issue 20, Page 1557-1559, May 17, 2022. (Circulation)

5 May

Circulation http://ahajournals.org/

• 11:00
  Efficacy and Safety of Dapagliflozin in Type 2 Diabetes According to Baseline Blood Pressure: Observations From DECLARE-TIMI 58 Trial - Remo H.M. Furtado Itamar Raz Erica L. Goodrich Sabina A. Murphy Deepak L. Bhatt Lawrence A. Leiter Darren K. McGuire John P.H. Wilding Philip Aylward Anthony J Dalby Mikael Dellborg Doina Dimulescu José C. Nicolau Anthonius J.M. Oude Ophuis Avivit Cahn Ofri Mosenzon Ingrid Gause-Nilsson Anna Maria Langkilde Marc S. Sabatine Stephen D. Wiviott Academic Research Organization, Hospital Israelita Albert Einstein, Sao Paulo, Brazil (R.H.M.F.). Instituto do Coracao (InCor), Hospital das Clinicas da Faculdade de Medicina, Universidade de Sao Paulo, Brazil (R.H.M.F., J.C.N.). TIMI Study Group, (...) Circulation
  Circulation, Volume 145, Issue 21, Page 1581-1591, May 24, 2022. Background:Dapagliflozin improved heart failure and kidney outcomes in patients with type 2 diabetes (T2DM) with or at high risk for atherosclerotic cardiovascular disease in the DECLARE-TIMI 58 trial (Dapagliflozin Effect on (...) (Circulation)

4 May

Circulation http://ahajournals.org/

• 07:07
  First-Line Catheter Ablation of Monomorphic Ventricular Tachycardia in Cardiomyopathy Concurrent With Defibrillator Implantation: The PAUSE-SCD Randomized Trial - Roderick Tung Yumei Xue Minglong Chen Chenyang Jiang Dalise Y. Shatz Stephanie A. Besser Hongde Hu Fa-Po Chung Shiro Nakahara Young-Hoon Kim Kazuhiro Satomi Lishui Shen Er’peng Liang Hongtao Liao Kai Gu Ruhong Jiang Jian Jiang Yuichi Hori Jong-Il Choi Akiko Ueda Yuki Komatsu Shuichiro Kazawa Kyoko Soejima Shih-Ann Chen Akihiko Nogami Yan Yao The University of Chicago, Center for Arrhythmia Care, Pritzker School of Medicine, IL (R.T., D.Y.S., S.A.B.). Fuwai Hospital, Arrhythmia Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical (...) Circulation
  Circulation, Volume 145, Issue 25, Page 1839-1849, June 21, 2022. Background:Catheter ablation as first-line therapy for ventricular tachycardia (VT) at the time of implantable cardioverter defibrillator (ICD) implantation has not been adopted into clinical guidelines. Also, there is an unmet (...) (Circulation)

3 May

Circulation http://ahajournals.org/

• 11:00
  Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity - Raja Chakraborty Allison C. Ostriker Yi Xie Jui M. Dave Ana Gamez-Mendez Payel Chatterjee Yaw Abu Jake Valentine Kimberly Lezon-Geyda Daniel M. Greif Vincent P. Schulz Patrick G. Gallagher William C. Sessa John Hwa Kathleen A. Martin Departments of Medicine (Cardiovascular Medicine) (R.C., A.C.O., Y.X., J.M.D., P.C., Y.A., J.V., D.M.G., J.H., K.A.M), Yale University School of Medicine, New Haven, CT. Pharmacology (R.C., A.C.O., Y.X., A.G.-M., P.C., Y.A., J.V., W.C.S., K.A.M.), Yale University School of Medicine, New Haven, CT. Genetics (J.M.D., D.M.G., P.G.G.), Yale University School of (...) Circulation
  Circulation, Volume 145, Issue 23, Page 1720-1737, June 7, 2022. Background:Vascular smooth muscle cell (VSMC) phenotypic switching contributes to cardiovascular diseases. Epigenetic regulation is emerging as a key regulatory mechanism, with the methylcytosine dioxygenase TET2 acting as a (...) (Circulation)

2 May

Circulation http://ahajournals.org/

• 11:00
  Trends in Opioid Use After Cardiac Implantable Electronic Device Procedures in the United States Between 2004 and 2020 - Timothy M. Markman Emily Folse Lin Yang Peter W. Groeneveld David S. Frankel Cardiovascular Division (T.M.M., D.S.F.), University of Pennsylvania, Philadelphia. Division of General Internal Medicine (P.W.G.), Perelman School of Medicine; and Center for Cardiovascular Outcomes, Quality, Evaluative Research (T.M.M., L.Y., P.W.G., D.S.F.), University of Pennsylvania, Philadelphia. Thomas Jefferson University School of Medicine, Philadelphia, PA (E.F.). Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (...) Circulation
  Circulation, Volume 145, Issue 19, Page 1499-1501, May 10, 2022. (Circulation)
• 08:00
  ECG Challenge: Electric Extremis in a Critically Ill Patient - Royce Kim Jeffrey Kolominsky Kenneth A. Ellenbogen Division of Cardiology, Pauley Heart Center, Virginia Commonwealth University, Richmond. Circulation
  Circulation, Volume 145, Issue 18, Page 1431-1433, May 3, 2022. (Circulation)
• 08:00
  Border Disputes Between Heart Failure Phenotypes - Walter J. Paulus Amsterdam University Medical Centers, The Netherlands. Circulation
  Circulation, Volume 145, Issue 18, Page 1374-1376, May 3, 2022. (Circulation)
• 08:00
  Letter by Duan et al Regarding Article, “Therapeutic Exon Skipping Through a CRISPR-Guided Cytidine Deaminase Rescues Dystrophic Cardiomyopathy In Vivo” - Dongsheng Duan Kevin M. Flanigan Annemieke Aartsma-Rus Department of Molecular Microbiology and Immunology and Department of Neurology, School of Medicine; Department of Biomedical Sciences, College of Veterinary Medicine; and Department of Biomedical, Biological & Chemical Engineering, College of Engineering, University of Missouri, Columbia (D.D.). Center for Gene Therapy, Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH (K.M.F.). Department of Pediatrics, The Ohio State University College of Medicine, Columbus (K.M.F.). Department of Human Genetics, Leiden (...) Circulation
  Circulation, Volume 145, Issue 18, Page e872-e873, May 3, 2022. (Circulation)
• 08:00
  Response by Li and Chang Regarding Article, “Therapeutic Exon Skipping Through a CRISPR-Guided Cytidine Deaminase Rescues Dystrophic Cardiomyopathy In Vivo” - Jia Li Xing Chang Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou Zhejiang, China. Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China. Circulation
  Circulation, Volume 145, Issue 18, Page e874-e875, May 3, 2022. (Circulation)
• 08:00
  Single-Cell RNA Sequencing Reveals a Distinct Immune Landscape of Myeloid Cells in Coronary Culprit Plaques Causing Acute Coronary Syndrome - Takuo Emoto Hiroyuki Yamamoto Tomoya Yamashita Tomofumi Takaya Takahiro Sawada Shintaro Takeda Masayuki Taniguchi Naoto Sasaki Naofumi Yoshida Yoshihiro Saito Tharini Sivasubramaniyam Hiromasa Otake Tomoyuki Furuyashiki Clinton S. Robbins Hiroya Kawai Ken-ichi Hirata Division of Cardiovascular Medicine, Department of Internal Medicine (T.E., T.Y., S.T., N.Y., Y.S., H.O., K.H.), Kobe University Graduate School of Medicine, Japan. Division of Cardiovascular Medicine, Department of Exploratory and Advanced Search in Cardiology (T.T., H.K.), Kobe University Graduate School of Medicine, Japan. (...) Circulation
  Circulation, Volume 145, Issue 18, Page 1434-1436, May 3, 2022. (Circulation)
• 08:00
  Prevalence of Short-Coupled Ventricular Fibrillation in a Large Cohort of Dutch Patients With Idiopathic Ventricular Fibrillation - Sanne A. Groeneveld Martijn H. van der Ree Bart A. Mulder Jippe Balt Arthur A.M. Wilde Pieter G. Postema Rutger J. Hassink Department of Cardiology, University Medical Center Utrecht, The Netherlands (S.A.G., R.J.H.). Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Cardiovascular Sciences, The Netherlands (M.H.v.d.R., A.A.M.W., P.G.P.). Department of Cardiology, University Medical Center Groningen, The Netherlands (B.A.M.). Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands (...) Circulation
  Circulation, Volume 145, Issue 18, Page 1437-1439, May 3, 2022. (Circulation)
• 08:00
  Road to Equity in Brain Health - Mitchell S.V. Elkind Michelle A. Albert Donald M. Lloyd-Jones Department of Neurology, Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (M.S.V.E.). Department of Medicine, Division of Cardiology, Center for the Study of Adversity and Cardiovascular Disease (NURTURE Center), School of Medicine, University of California at San Francisco, San francisco, CA (M.A.A.). Departments of Preventive Medicine, Medicine, and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL (...) Circulation
  Circulation, Volume 145, Issue 18, Page e869-e871, May 3, 2022. (Circulation)
• 08:00
  Correction to: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines Circulation
  Circulation, Volume 145, Issue 18, Page e1033-e1033, May 3, 2022. (Circulation)
• 08:00
  Flexing Their Muscles: Maturation of Stem Cell–Derived Cardiomyocytes on Elastomeric Substrates to Enhance Cardiac Repair - Elaheh Karbassi Charles E. Murry Institute for Stem Cell and Regenerative Medicine, Center for Cardiovascular Biology, and Department of Laboratory Medicine & Pathology (E.K., C.E.M.), University of Washington, Seattle. Division of Cardiology, Department of Medicine (C.E.M.), University of Washington, Seattle. Department of Bioengineering (C.E.M.), University of Washington, Seattle. Sana Biotechnology, Seattle, WA (C.E.M.). Circulation
  Circulation, Volume 145, Issue 18, Page 1427-1430, May 3, 2022. (Circulation)

1 May

Circulation http://ahajournals.org/

• 11:00
  Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2–Deficient Hearts - Chantal J.M. van Opbergen Navratan Bagwan Svetlana R. Maurya Joon-Chul Kim Abigail N. Smith Daniel J. Blackwell Jeffrey N. Johnston Björn C. Knollmann Marina Cerrone, Alicia Lundby Mario Delmar The Leon Charney Division of Cardiology, New York University Grossmann School of Medicine (C.J.M.v.O., J.-C.K., M.C., M.D.). Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (N.B., S.R.M., A.L.). Department of Chemistry & Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN (A.N.S., J.N.J.). Vanderbilt Center for (...) Circulation
  Circulation, Volume 145, Issue 19, Page 1480-1496, May 10, 2022. Background:Exercise training, and catecholaminergic stimulation, increase the incidence of arrhythmic events in patients affected with arrhythmogenic right ventricular cardiomyopathy correlated with plakophilin-2 (PKP2) mutations. (...) (Circulation)

25 April

Circulation http://ahajournals.org/

• 11:00
  Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial - Axel C.P. Diederichsen Jes S. Lindholt Sören Möller Kristian A. Øvrehus Søren Auscher Jess Lambrechtsen Susanne E. Hosbond Dilek H. Alan Grazina Urbonaviciene Søren W. Becker Maise H. Fredgart Selma Hasific Lars Folkestad Oke Gerke Lars Melholt Rasmussen Jacob E. Møller Hans Mickley Jordi S. Dahl Department of Cardiology (A.C.P.D., K.A.Ø., M.H.F., S.H.‚ H.M., J.S.D.), Odense University Hospital, Denmark. Department of Cardiothoracic and Vascular Surgery (J.S.L.), Odense University Hospital, Denmark. Open Patient Data Explorative Network (S.M.), Odense University Hospital, Denmark. Department of (...) Circulation
  Circulation, Volume 145, Issue 18, Page 1387-1397, May 3, 2022. Background:Menaquinone-7 (MK-7), also known as vitamin K2, is a cofactor for the carboxylation of proteins involved in the inhibition of arterial calcification and has been suggested to reduce the progression rate of aortic valve (...) (Circulation)
• 08:00
  The Social Robots Are Coming: Preparing for a New Wave of Virtual Care in Cardiovascular Medicine - Karen Bouchard Peter P. Liu Heather Tulloch University of Ottawa Heart Institute, Canada (K.B., P.P.L., H.T.). University of Ottawa, Canada (K.B., P.P.L., H.T.). Circulation
  Circulation, Volume 145, Issue 17, Page 1291-1293, April 26, 2022. (Circulation)
• 08:00
  Letter by Dhruva and Redberg Regarding Article, “Amplatzer Amulet Left Atrial Appendage Occluder Versus Watchman Device for Stroke Prophylaxis (Amulet IDE): A Randomized, Controlled Trial” - Sanket S. Dhruva Rita F. Redberg Philip R. Lee Institute for Health Policy Studies (S.S.D., R.F.R.) University of California, San Francisco. Section of Cardiology, Department of Medicine, San Francisco Veterans Affairs Medical Center, CA (S.S.D.). Department of Medicine, Division of Cardiology (R.F.R.), University of California, San Francisco School of Medicine, San Francisco. Circulation
  Circulation, Volume 145, Issue 17, Page e845-e846, April 26, 2022. (Circulation)
• 08:00
  Fast and Furious: A Case of Group Beating and Cardiomyopathy - Salwa Rahman Angelo Biviano Hirad Yarmohammadi Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York. Circulation
  Circulation, Volume 145, Issue 17, Page 1364-1366, April 26, 2022. (Circulation)
• 08:00
  Letter by Natale et al Regarding Article, “Amplatzer Amulet Left Atrial Appendage Occluder Versus Watchman Device for Stroke Prophylaxis (Amulet IDE): A Randomized, Controlled Trial” - Andrea Natale Saibal Kar David Holmes Texas Cardiac Arrythmia Institute, Austin, TX (A.N.). Los Robles Regional Medical Center, Thousand Oaks, CA (S.K.). Mayo Clinic, Rochester, MN (D.H.). Circulation
  Circulation, Volume 145, Issue 17, Page e847-e848, April 26, 2022. (Circulation)
• 08:00
  Letter by Price et al Regarding the Article, “Amplatzer Amulet Left Atrial Appendage Occluder Versus Watchman Device for Stroke Prophylaxis (Amulet IDE): A Randomized, Controlled Trial” - Matthew J. Price Doug N. Gibson Saibal Kar Division of Cardiovascular Diseases, Scripps Clinic, La Jolla, CA (M.J.P., D.NG.). Los Robles Regional Medical Center, Thousand Oaks, CA (S.K.). Circulation
  Circulation, Volume 145, Issue 17, Page e849-e849, April 26, 2022. (Circulation)
• 08:00
  Response by Lakireddy et al to Letters Regarding Article, “Amplatzer Amulet Left Atrial Appendage Occluder Versus Watchman Device for Stroke Prophylaxis (Amulet IDE): A Randomized, Controlled Trial” - Dhanunjaya Lakkireddy David Thaler Stephan Windecker Kansas City Heart Rhythm Institute and Research Foundation, Overland Park, KS (D.L.). Tufts Medical Center, Boston, MA (D.T.). Inselspital, University of Bern, Switzerland (S.W). Circulation
  Circulation, Volume 145, Issue 17, Page e850-e851, April 26, 2022. (Circulation)
• 08:00
  Modeling Effects of Immunosuppressive Drugs on Human Hearts Using Induced Pluripotent Stem Cell–Derived Cardiac Organoids and Single-Cell RNA Sequencing - Karim Sallam Dilip Thomas Sadhana Gaddam Nicole Lopez Aimee Beck Leila Beach Albert J. Rogers Hao Zhang Ian Y. Chen Mohamed Ameen William Hiesinger Jeffrey J. Teuteberg June-Wha Rhee Kevin C. Wang Nazish Sayed Joseph C. Wu Stanford Cardiovascular Institute (K.S., D.T., N.L., A.B., A.J.R., H.Z., I.Y.C., M.A., J.-W.R., N.S., J.C.W.), Stanford University School of Medicine, CA. Division of Cardiovascular Medicine, Department of Medicine (K.S., L.B., A.J.R., I.Y.C., J.J.T., J.-W.R., J.C.W.), Stanford University School of Medicine, CA. Department of Cardiothoracic Surgery (W.H.), Stanford (...) Circulation
  Circulation, Volume 145, Issue 17, Page 1367-1369, April 26, 2022. (Circulation)
• 08:00
  Correction to: Prevention of Viridans Group Streptococcal Infective Endocarditis: A Scientific Statement From the American Heart Association Circulation
  Circulation, Volume 145, Issue 17, Page e868-e868, April 26, 2022. (Circulation)
• 08:00
  Improving Symptoms and Quality of Life in Stable Coronary Artery Disease: An Evolving Paradigm - Krishna K. Patel Icahn School of Medicine at Mount Sinai, New York. Circulation
  Circulation, Volume 145, Issue 17, Page 1308-1311, April 26, 2022. (Circulation)
• 08:00
  At the Brink of Human Therapy to Generate New Myocytes in the Adult Injured Heart - Vikram Prasad Jeffery D. Molkentin Cincinnati Children’s Hospital Medical Center, University of Cincinnati, OH. Circulation
  Circulation, Volume 145, Issue 17, Page 1356-1358, April 26, 2022. (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 145, Issue 17, Page 1359-1363, April 26, 2022. (Circulation)

22 April

Circulation http://ahajournals.org/

• 11:00
  Hourly Air Pollutants and Acute Coronary Syndrome Onset in 1.29 Million Patients - Renjie Chen Yixuan Jiang Jialu Hu Honglei Chen Huichu Li Xia Meng John S. Ji Ya Gao Weidong Wang Cong Liu Weiyi Fang Hongbing Yan Jiyan Chen Weimin Wang Dingcheng Xiang Xi Su Bo Yu Yan Wang Yawei Xu Lefeng Wang Chunjie Li Yundai Chen Michelle L. Bell Aaron J. Cohen Junbo Ge Yong Huo Haidong Kan School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and National Health Commission Key Lab of Health Technology Assessment, Fudan University‚ Shanghai‚ China (R.C., Y.J., X.M., Y.G., Weidong Wang, C. Liu, H.K.). Department of Cardiology, Zhongshan Hospital, Fudan (...) Circulation
  Circulation, Volume 145, Issue 24, Page 1749-1760, June 14, 2022. Background:Short-term exposure to ambient air pollution has been linked with daily hospitalization and mortality from acute coronary syndrome (ACS); however, the associations of subdaily (hourly) levels of criteria air pollutants (...) (Circulation)

20 April

Circulation http://ahajournals.org/

• 05:56
  Initial Decline (Dip) in Estimated Glomerular Filtration Rate After Initiation of Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction: Insights From DAPA-HF - Carly Adamson Kieran F. Docherty Hiddo J.L. Heerspink Rudolf A. de Boer Kevin Damman Silvio E. Inzucchi Lars Køber Mikhail N. Kosiborod Felipe A. Martinez Mark C. Petrie Piotr Ponikowski Marc S. Sabatine Morten Schou Scott D. Solomon Subodh Verma Olof Bengtsson Anna Maria Langkilde Mikaela Sjöstrand Muthiah Vaduganathan Pardeep S. Jhund John J.V. McMurray BHF Cardiovascular Research Centre, University of Glasgow, UK (C.A., K.F.D., M.D.P., P.S.J., J.J.V.M.). Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands. (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:In a post hoc analysis, the frequency of occurrence of an early decline (dip) in estimated glomerular filtration rate (eGFR) after initiation of dapagliflozin and its association with outcomes were evaluated in patients with heart failure and reduced (...) (Circulation)

19 April

Circulation http://ahajournals.org/

• 11:00
  Progressive Reduction in Right Ventricular Contractile Function Attributable to Altered Actin Expression in an Aging Mouse Model of Arrhythmogenic Cardiomyopathy - Emmanuel M. Camors Alyson H. Roth Joseph R. Alef Ryan D. Sullivan Jason N. Johnson Enkhsaikhan Purevjav Jeffrey A. Towbin Heart Institute, Department of Pediatrics, University of Tennessee Health Science Center, Memphis (E.M.C., A.H.R., J.R.A., J.N.J., E.P., J.A.T.). Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN (E.M.C., A.H.R., J.R.A., J.N.J., E.P., J.A.T.). Department of Internal Medicine, University of Arizona College of Medicine, Phoenix (R.D.S.). Pediatric Cardiology, St. Jude Children’s Research Hospital, Memphis, TN (J.N.J., (...) Circulation
  Circulation, Volume 145, Issue 21, Page 1609-1624, May 24, 2022. Background:Arrhythmogenic cardiomyopathy (ACM) is an inherited genetic disorder of desmosomal dysfunction, and PKP2 (plakophilin-2) has been reported to be the most common disease-causing gene when mutation-positive. In the early (...) (Circulation)

18 April

Circulation http://ahajournals.org/

• 11:00
  Cardiac Resident Macrophage-Derived Legumain Improves Cardiac Repair by Promoting Clearance and Degradation of Apoptotic Cardiomyocytes After Myocardial Infarction - Daile Jia Siqin Chen Peiyuan Bai Chentao Luo Jin Liu Aijun Sun Junbo Ge Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, China (D.J., P.B., J.L., A.S., J.G.). Key Laboratory of Viral Heart Diseases, National Health Commission, Shanghai, China (D.J., S.C., P.B., J.L., A.S., J.G.). Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China (D.J., S.C., P.B., J.L., A.S., J.G.). Institutes of Biomedical Sciences, Fudan University, Shanghai, China (S.C., A.S., J.G.). Department of Cardiovascular (...) Circulation
  Circulation, Volume 145, Issue 20, Page 1542-1556, May 17, 2022. Background:Cardiac resident macrophages are self-maintaining and originate from embryonic hematopoiesis. After myocardial infarction, cardiac resident macrophages are responsible for the efficient clearance and degradation of (...) (Circulation)
• 11:01
  Temporal Trends in the Remaining Lifetime Risk of Cardiovascular Disease Among Middle-Aged Adults Across 6 Decades: The Framingham Study - Ramachandran S. Vasan Danielle M. Enserro Vanessa Xanthakis Alexa S. Beiser Sudha Seshadri Boston University and the National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, MA (R.S.V., V.X., A.S.B., S.S.). Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, MA (R.S.V., V.X.). Department of Epidemiology (R.S.V.), Boston University School of Public Health, MA. Department of Biostatistics (V.X., A.S.B.), Boston University School of Public Health, MA. NRG Oncology and Clinical Trials Development Division, (...) Circulation
  Circulation, Volume 145, Issue 17, Page 1324-1338, April 26, 2022. Background:The remaining lifetime risk (RLR) is the probability of developing an outcome over the remainder of one’s lifespan at any given age. The RLR for atherosclerotic cardiovascular disease (ASCVD) in three 20-year periods (...) (Circulation)
• 08:00
  Letter by Gronda et al Regarding Article, “Effect of Empagliflozin on Worsening Heart Failure Events in Patients With Heart Failure and Preserved Ejection Fraction: EMPEROR-Preserved Trial” - Edoardo Gronda Furio Colivicchi Giuseppe Zuccalà UOC di Nefrolo- gia, Dialisi e Trapianto Renale dell’Adulto, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico. Milan, Italy (E.G.). Azienda Complesso Ospedaliero San Filippo Neri, Rome, Italy (F.C.). Cardiologia Clinica e Riabilitativa, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy (G.Z.). Circulation
  Circulation, Volume 145, Issue 16, Page e839-e840, April 19, 2022. (Circulation)
• 08:00
  Sinus Node Dysfunction With a Nice Twist - Aviram Hochstadt Raphael Rosso Sami Viskin Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, Israel. Circulation
  Circulation, Volume 145, Issue 16, Page 1285-1287, April 19, 2022. (Circulation)
• 08:00
  Percutaneous Transvalvular Microaxial Flow Pump Support in Cardiology - Enzo Lüsebrink Antonia Kellnar Kathrin Krieg Leonhard Binzenhöfer Clemens Scherer Sebastian Zimmer Benedikt Schrage Stephanie Fichtner Tobias Petzold Daniel Braun Sven Peterss Stefan Brunner Christian Hagl Dirk Westermann Jörg Hausleiter Steffen Massberg Holger Thiele Andreas Schäfer Martin Orban Cardiac Intensive Care Unit, Medizinische Klinik und Poliklinik I (E.L., A.K., K.K., L.B., C.S., S.F., T.P., D.B., S.B., J.H., S.M., M.O.), Klinikum der Universität München, and German Center for Cardiovascular Research, partner site Munich Heart Alliance. Herzchirurgische Klinik und Poliklinik (S.P., (...) Circulation
  Circulation, Volume 145, Issue 16, Page 1254-1284, April 19, 2022. The Impella device (Impella, Abiomed, Danvers, MA) is a percutaneous transvalvular microaxial flow pump that is currently used for (1) cardiogenic shock, (2) left ventricular unloading (combination of venoarterial extracorporeal (...) (Circulation)
• 08:00
  Price and Quality in the Generic Pharmaceutical Market - Ben Teasdale David Light Kevin A. Schulman Clinical Excellence Research Center, School of Medicine (B.T., K.A.S.), Stanford University, Palo Alto, CA. Graduate School of Business (K.A.S.), Stanford University, Palo Alto, CA. Valisure, LLC, New Haven, CT (D.L.). Circulation
  Circulation, Volume 145, Issue 16, Page 1185-1187, April 19, 2022. (Circulation)
• 08:00
  Correction to: Coronary Artery and Cardiac Disease in Patients With Type 2 Myocardial Infarction: A Prospective Cohort Study Circulation
  Circulation, Volume 145, Issue 16, Page e841-e841, April 19, 2022. (Circulation)
• 08:00
  Correction to: Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration Circulation
  Circulation, Volume 145, Issue 16, Page e842-e842, April 19, 2022. (Circulation)
• 08:00
  Correction to: Protein Kinase C? Via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6Chi Cells Contributes to Atherosclerosis Circulation
  Circulation, Volume 145, Issue 16, Page e843-e843, April 19, 2022. (Circulation)
• 08:00
  Correction to: Impact of S-Adenosylmethionine Decarboxylase 1 on Pulmonary Vascular Remodeling Circulation
  Circulation, Volume 145, Issue 16, Page e844-e844, April 19, 2022. (Circulation)
• 08:00
  Zooming in on the Enigmas of Type 2 Myocardial Infarction - Harvey D. White Green Lane Cardiovascular Department, Auckland City Hospital and Auckland University, New Zealand. Circulation
  Circulation, Volume 145, Issue 16, Page 1201-1204, April 19, 2022. (Circulation)
• 08:00
  Exercise-Induced Long Noncoding RNAs As New Players in Cardiac Hypertrophy - Catherine A. Makarewich Thomas Thum The Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children’s Hospital Medical Center, OH (C.A.M.). Department of Pediatrics, University of Cincinnati College of Medicine, OH (C.A.M.). Institute of Molecular and Translational Therapeutic Strategies; REBIRTH Center for Translational Regenerative Medicine, Hannover Medical School; and Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany (...) Circulation
  Circulation, Volume 145, Issue 16, Page 1234-1237, April 19, 2022. (Circulation)

15 April

Circulation http://ahajournals.org/

• 11:00
  Deep Lipidomics in Human Plasma: Cardiometabolic Disease Risk and Effect of Dietary Fat Modulation - Fabian Eichelmann Laury Sellem Clemens Wittenbecher Susanne Jäger Olga Kuxhaus Marcela Prada Rafael Cuadrat Kim G. Jackson Julie A. Lovegrove Matthias B. Schulze Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal (F.E., C.W., S.J., O.K., M.P., R.C., M.B.S.). German Center for Diabetes Research (DZD), Neuherberg (F.E., S.J., O.K., M.P., R.C., M.B.S.). Hugh Sinclair Unit of Human Nutrition, and Institute for Cardiovascular and Metabolic Research, Department of Food and Nutritional Science, University of Reading, United Kingdom (L.S., (...) Circulation
  Circulation, Volume 146, Issue 1, Page 21-35, July 5, 2022. Background:In blood and tissues, dietary and endogenously generated fatty acids (FAs) occur in free form or as part of complex lipid molecules that collectively represent the lipidome of the respective tissue. We assessed associations (...) (Circulation)

11 April

Circulation http://ahajournals.org/

• 11:00
  Rewiring of 3D Chromatin Topology Orchestrates Transcriptional Reprogramming and the Development of Human Dilated Cardiomyopathy - Yuliang Feng Liuyang Cai Wanzi Hong Chunxiang Zhang Ning Tan Mingyang Wang Cheng Wang Feng Liu Xiaohong Wang Jianyong Ma Chen Gao Mohit Kumar Yuanxi Mo Qingshan Geng Changjun Luo Yan Lin Haiyang Chen Shuang-Yin Wang Michael J. Watson Anil G. Jegga Roger A. Pedersen Ji-dong Fu Zhao V. Wang Guo-Chang Fan Sakthivel Sadayappan Yigang Wang Siim Pauklin Feng Huang Wei Huang Lei Jiang Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK (Y.F., F.L., S.P.). Department of Microbiology, Faculty of Medicine, The Chinese (...) Circulation
  Circulation, Volume 145, Issue 22, Page 1663-1683, May 31, 2022. Background:Transcriptional reconfiguration is central to heart failure, the most common cause of which is dilated cardiomyopathy (DCM). The effect of 3-dimensional chromatin topology on transcriptional dysregulation and (...) (Circulation)
• 11:37
  Computational Analysis of Routine Biopsies Improves Diagnosis and Prediction of Cardiac Allograft Vasculopathy - Eliot G. Peyster Andrew Janowczyk Abigail Swamidoss Samhith Kethireddy Michael D. Feldman Kenneth B. Margulies Cardiovascular Research Institute (E.G.P., K.B.M.), University of Pennsylvania, Philadelphia. Department of Pathology and Laboratory Medicine (M.D.F.), University of Pennsylvania, Philadelphia. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH (A.J., A.S., S.K.). Department of Oncology, Lausanne University Hospital and Lausanne University, Switzerland (...) Circulation
  Circulation, Volume 145, Issue 21, Page 1563-1577, May 24, 2022. Background:Cardiac allograft vasculopathy (CAV) is a leading cause of morbidity and mortality for heart transplant recipients. Although clinical risk factors for CAV have been established, no personalized prognostic test exists to (...) (Circulation)
• 11:01
  SARS-CoV-2 Infection and Associated Cardiovascular Manifestations and Complications in Children and Young Adults: A Scientific Statement From the American Heart Association - Pei-Ni Jone Anitha John Matthew E. Oster Kiona Allen Adrianna H. Tremoulet Elizabeth V. Saarel Linda M. Lambert Shelley D. Miyamoto Sarah D. de Ferranti Circulation
  Circulation, Volume 145, Issue 19, Page e1037-e1052, May 10, 2022. Coronavirus disease 2019 (COVID-19) resulted in a global pandemic and has overwhelmed health care systems worldwide. In this scientific statement, we describe the epidemiology, pathophysiology, clinical presentations, treatment, (...) (Circulation)
• 08:00
  Prevalence, Characteristics, and Outcomes of COVID-19–Associated Acute Myocarditis - Enrico Ammirati Laura Lupi Matteo Palazzini Nicholas S. Hendren Justin L. Grodin Carlo V. Cannistraci Matthieu Schmidt Guillaume Hekimian Giovanni Peretto Thomas Bochaton Ahmad Hayek Nicolas Piriou Sergio Leonardi Stefania Guida Annalisa Turco Simone Sala Aitor Uribarri Caroline M. Van de Heyning Massimo Mapelli Jeness Campodonico Patrizia Pedrotti Maria Isabel Barrionuevo Sánchez Albert Ariza Sole Marco Marini Maria Vittoria Matassini Mickael Vourc’h Antonio Cannatà Daniel I. Bromage Daniele Briguglia Jorge Salamanca Pablo Diez-Villanueva Jukka Lehtonen Florent Huang Stéphanie Russel (...) Circulation
  Circulation, Volume 145, Issue 15, Page 1123-1139, April 12, 2022. Background:Acute myocarditis (AM) is thought to be a rare cardiovascular complication of COVID-19, although minimal data are available beyond case reports. We aim to report the prevalence, baseline characteristics, in-hospital (...) (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 145, Issue 15, Page 1169-1174, April 12, 2022. (Circulation)
• 08:00
  Unrepairable Infant Mitral Valve: An Unexpected Case of Decompensated Heart Failure - Alexander K. Reed Peter Chiu Chrystalle Katte Carreon Stephen P. Sanders Pedro J. del Nido Christopher W. Baird Harvard Medical School, Boston, MA (A.K.R.). Department of Cardiac Surgery (P.C., P.J.d.N., C.W.B.), Boston Children’s Hospital/Harvard Medical School, MA. Department of Pathology (C.K.C., S.P.S.), Boston Children’s Hospital/Harvard Medical School, MA. Cardiac Registry, Departments of Cardiology, Pathology, and Cardiac Surgery, Boston Children’s Hospital, MA (C.K.C., (...) Circulation
  Circulation, Volume 145, Issue 15, Page 1175-1178, April 12, 2022. (Circulation)
• 08:00
  Prioritizing Quad Therapy and the Path Forward in Guideline-Directed Medical Therapy for Patients With Heart Failure With Reduced Ejection Fraction - Josephine Harrington Robert J. Mentz Duke University School of Medicine (J.H., R.J.M.), Durham, NC. Duke Clinical Research Institute (J.H., R.J.M.), Durham, NC. Circulation
  Circulation, Volume 145, Issue 15, Page 1105-1107, April 12, 2022. (Circulation)
• 08:00
  Letter by Trimaille et al Regarding Article, “Native Aortic Valve Disease Progression and Bioprosthetic Valve Degeneration in Patients With Transcatheter Aortic Valve Implantation” - Antonin Trimaille Sandy Hmadeh Olivier Morel Department of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, France (A.T., O.M.). Institut National de la Santé Et de la Recherche Médicale (French National Institute of Health and Medical Research), Unité Mixte de Recherche 1260, Regenerative Nanomedicine, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg, France (A.T., S.H., O.M.). Circulation
  Circulation, Volume 145, Issue 15, Page e807-e808, April 12, 2022. (Circulation)
• 08:00
  Response by Kwiecinski et al to Letter Regarding Article, “Native Aortic Valve Disease Progression and Bioprosthetic Valve Degeneration in Patients With Transcatheter Aortic Valve Implantation” - Jacek Kwiecinski Evangelos Tzolos Rong Bing Marc R. Dweck Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland (J.K.). Centre for Cardiovascular Science, University of Edinburgh, UK (E.T., R.B., M.R.D.). Circulation
  Circulation, Volume 145, Issue 15, Page e809-e810, April 12, 2022. (Circulation)
• 08:00
  Dual Genetic Lineage Tracing Reveals Capillary to Artery Formation in the Adult Heart - Maoying Han Zixin Liu Lingjuan He Xufeng Li Lei Liu Xiuzhen Huang Mingjun Zhang Yan Yan Kathy O. Lui Bin Zhou The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (M.H., Z.L., X.H., M.Z., B.Z.), University of Chinese Academy of Sciences, Shanghai, China. School of Life Science, Hangzhou Institute for Advanced Study (X.L., B.Z.), University of Chinese Academy of Sciences, Shanghai, China. Science and Technology, ShanghaiTech University, China (M.H., L.L., B.Z.). School (...) Circulation
  Circulation, Volume 145, Issue 15, Page 1179-1181, April 12, 2022. (Circulation)
• 08:00
  In Utero Brain Growth Matters for Fetuses With Congenital Heart Disease - Mike Seed Catherine Limperopoulos Department of Paediatrics, Hospital for Sick Children, University of Toronto, Canada (M.S.). Department of Pediatrics, George Washington University School of Medicine, Washington, DC (C.L.). Circulation
  Circulation, Volume 145, Issue 15, Page 1120-1122, April 12, 2022. (Circulation)

8 April

Circulation http://ahajournals.org/

• 08:08
  Sodium-Glucose Cotransporter 2 Inhibitors and Risk of Hyperkalemia in People With Type 2 Diabetes: A Meta-Analysis of Individual Participant Data From Randomized, Controlled Trials - Brendon L. Neuen Megumi Oshima Rajiv Agarwal Clare Arnott David Z. Cherney Robert Edwards Anna Maria Langkilde Kenneth W. Mahaffey Darren K. McGuire Bruce Neal Vlado Perkovic Annpey Pong Marc S. Sabatine Itamar Raz Tadashi Toyama Christoph Wanner David C. Wheeler Stephen D. Wiviott Bernard Zinman Hiddo J.L. Heerspink The George Institute for Global Health, University of New South Wales, Sydney, Australia (B.L.N., C.A.). Department of Nephrology and Laboratory Medicine, Kanazawa University, Japan (M.O., T.T.). Indiana University School of Medicine and VA Medical Center, Indianapolis (...) Circulation
  Circulation, Volume 145, Issue 19, Page 1460-1470, May 10, 2022. Background:Hyperkalemia increases risk of cardiac arrhythmias and death and limits the use of renin-angiotensin-aldosterone system inhibitors and mineralocorticoid receptor antagonists, which improve clinical outcomes in people (...) (Circulation)

7 April

Circulation http://ahajournals.org/

• 10:10
  Skeletal Muscle Disorders: A Noncardiac Source of Cardiac Troponin T - Jeanne du Fay de Lavallaz Alexandra Prepoudis Maria Janina Wendebourg Eva Kesenheimer Diego Kyburz Thomas Daikeler Philip Haaf Julia Wanschitz Wolfgang N. Löscher Bettina Schreiner Mira Katan Hans H. Jung Britta Maurer Angelika Hammerer-Lercher Agnes Mayr Danielle M. Gualandro Annemarie Acket Christian Puelacher Jasper Boeddinghaus Thomas Nestelberger Pedro Lopez-Ayala Noemi Glarner Samyut Shrestha Robert Manka Joanna Gawinecka Salvatore Piscuoglio John Gallon Sophia Wiedemann Michael Sinnreich Christian Mueller Cardiovascular Research Institute Basel (J.d.F.d.L., A.P., P.H., D.M.G., A.A., (...) Circulation
  Circulation, Volume 145, Issue 24, Page 1764-1779, June 14, 2022. Background:Cardiac troponin (cTn) T and cTnI are considered cardiac specific and equivalent in the diagnosis of acute myocardial infarction. Previous studies suggested rare skeletal myopathies as a noncardiac source of cTnT. We (...) (Circulation)
• 07:00
  Monogenic and Polygenic Contributions to QTc Prolongation in the Population - Victor Nauffal Valerie N. Morrill Sean J. Jurgens Seung Hoan Choi Amelia W. Hall Lu-Chen Weng Jennifer L. Halford Christina Austin-Tse Christopher M. Haggerty Stephanie L. Harris Eugene K. Wong Alvaro Alonso Dan E. Arking Emelia J. Benjamin Eric Boerwinkle Yuan-I Min Adolfo Correa Brandon K. Fornwalt Susan R. Heckbert Charles Kooperberg Henry J. Lin Ruth J.F. Loos Kenneth M. Rice Namrata Gupta Thomas W. Blackwell Braxton D. Mitchell Alanna C. Morrison Bruce M. Psaty Wendy S. Post Susan Redline Heidi L. Rehm Stephen S. Rich Jerome I. Rotter Elsayed Z. Soliman Nona Sotoodehnia Kathryn L. (...) Circulation
  Circulation, Volume 145, Issue 20, Page 1524-1533, May 17, 2022. Background:Rare sequence variation in genes underlying cardiac repolarization and common polygenic variation influence QT interval duration. However, current clinical genetic testing of individuals with unexplained QT prolongation (...) (Circulation)
• 05:46
  Association of Bleeding Severity With Mortality in Extended Thromboprophylaxis of Medically Ill Patients in the MAGELLAN and MARINER Trials - Alex C. Spyropoulos Gary E. Raskob Alexander T. Cohen Walter Ageno Jeffrey I. Weitz Theodore E. Spiro Wentao Lu Concetta Lipardi Gregory W. Albers C. Gregory Elliott Jonathan L. Halperin William R. Hiatt Gregory Maynard P. Gabriel Steg Chiara Sugarmann Elliot S. Barnathan Feinstein Institute for Medical Research, Department of Medicine, Anticoagulation and Clinical Thrombosis Services Northwell Health at Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York (A.C.S.). Hudson College of Public Health, University of Oklahoma Health Sciences Center, (...) Circulation
  Circulation, Volume 145, Issue 19, Page 1471-1479, May 10, 2022. Background:Extended thromboprophylaxis has not been widely implemented in acutely ill medical patients because of bleeding concerns. The MAGELLAN (Multicenter, Randomized, Parallel Group Efficacy and Safety Study for the (...) (Circulation)
• 11:00
  Genetic Landscape of the ACE2 Coronavirus Receptor - Zhijian Yang Erin Macdonald-Dunlop Jiantao Chen Ranran Zhai Ting Li Anne Richmond Lucija Klari? Nicola Pirastu Zheng Ning Chenqing Zheng Yipeng Wang Tingting Huang Yazhou He Huiming Guo Kejun Ying Stefan Gustafsson Bram Prins Anna Ramisch Emmanouil T. Dermitzakis Grace Png Niclas Eriksson Jeffrey Haessler Xiaowei Hu Daniela Zanetti Thibaud Boutin Shih-Jen Hwang Eleanor Wheeler Maik Pietzner Laura M. Raffield Anette Kalnapenkis James E. Peters Ana Viñuela Arthur Gilly Sölve Elmståhl George Dedoussis John R. Petrie Ozren Polašek Lasse Folkersen Yan Chen Chen Yao Urmo Võsa Erola Pairo-Castineira (...) Circulation
  Circulation, Volume 145, Issue 18, Page 1398-1411, May 3, 2022. Background:SARS-CoV-2, the causal agent of COVID-19, enters human cells using the ACE2 (angiotensin-converting enzyme 2) protein as a receptor. ACE2 is thus key to the infection and treatment of the coronavirus. ACE2 is highly (...) (Circulation)

6 April

Circulation http://ahajournals.org/

• 04:05
  Muscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy - Muhammad Riaz Jinkyu Park Lorenzo R. Sewanan Yongming Ren Jonas Schwan Subhash K. Das Pawel T. Pomianowski Yan Huang Matthew W. Ellis Jiesi Luo Juli Liu Loujin Song I-Ping Chen Caihong Qiu Masayuki Yazawa George Tellides John Hwa Lawrence H. Young Lei Yang Charles C. Marboe Daniel L. Jacoby Stuart G. Campbell Yibing Qyang Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine (M.R., J.P., Y.R., S.K.D., Y.H., M.W.E., J. Luo, J.H., L.H.Y., D.L.J., Y.Q.), Yale University School of Medicine, New Haven, CT. Department of Pathology (M.R., J.P., (...) Circulation
  Circulation, Volume 145, Issue 16, Page 1238-1253, April 19, 2022. Background:Familial hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease and is typically caused by mutations in genes encoding sarcomeric proteins that regulate cardiac contractility. HCM (...) (Circulation)

4 April

Circulation http://ahajournals.org/

• 06:45
  Effects of Empagliflozin on Symptoms, Physical Limitations, and Quality of Life in Patients Hospitalized for Acute Heart Failure: Results From the EMPULSE Trial - Mikhail N. Kosiborod Christiane E. Angermann Sean P. Collins John R. Teerlink Piotr Ponikowski Jan Biegus Josep Comin-Colet João Pedro Ferreira Robert J. Mentz Michael E. Nassif Mitchell A. Psotka Jasper Tromp Martina Brueckmann Jonathan P. Blatchford Afshin Salsali Adriaan A. Voors Saint Luke’s Mid America Heart Institute, Kansas City, MO (M.N.K., M.E.N.). School of Medicine, University of Missouri-Kansas City (M.N.K., M.E.N.). The George Institute for Global Health, University of New South Wales, Sydney, Australia (M.N.K.). Comprehensive Heart Failure Centre, University and University (...) Circulation
  Circulation, Volume 146, Issue 4, Page 279-288, July 26, 2022. Background:Patients hospitalized for acute heart failure experience poor health status, including a high burden of symptoms and physical limitations, and poor quality of life. SGLT2 (sodium-glucose cotransporter 2) inhibitors (...) (Circulation)
• 14:30
  Edoxaban versus Dual Antiplatelet Therapy for Leaflet Thrombosis and Cerebral Thromboembolism after TAVR: The ADAPT-TAVR Randomized Clinical Trial - Duk-Woo Park Jung-Min Ahn Do-Yoon Kang Kyung Won Kim Hyun Jung Koo Dong Hyun Yang Seung Chai Jung Byungjun Kim Yiu Tung Anthony Wong Cheung Chi Simon Lam Wei-Hsian Yin Jeng Wei Yung-Tsai Lee Hsien-Li Kao Mao-Shin Lin Tsung-Yu Ko Won-Jang Kim Se Hun Kang Sung-Cheol Yun Seung-Ah Lee Euihong Ko Hanbit Park Dae-Hee Kim Joon-Won Kang Jae-Hong Lee Seung-Jung Park Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Asan Image Metrics, Clinical Trial Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea Department of Radiology (...) Circulation
  Circulation, Ahead of Print. Background:It is unknown whether direct oral anticoagulant edoxaban can reduce leaflet thrombosis and the accompanying cerebral thromboembolic risk after transcatheter aortic-valve replacement (TAVR). Also, the causal relationship of subclinical leaflet thrombosis (...) (Circulation)
• 05:00
  Randomized Trial of Chocolate Touch Compared With Lutonix Drug-Coated Balloon in Femoropopliteal Lesions (Chocolate Touch Study) - Mehdi H. Shishehbor Thomas Zeller Martin Werner Marianne Brodmann Helen Parise Andrew Holden Michael Lichtenberg Sahil A. Parikh Vikram S. Kashyap Cody Pietras Daniela Tirziu Shiva Ardakani Ulrich Beschorner Prakash Krishnan Khusrow A. Niazi Andreas U. Wali Alexandra J. Lansky University Hospitals Harrington Heart and Vascular Institute, Cleveland, OH (M.H.S., V.S.K.). University Heart Center Freiburg, Bad Krozingen, Germany (T.Z., U.B.). Department of Angiology, Hanusch Hospital, Vienna, Austria (M.W.). Medical University of Graz, Austria (M.B.). Yale University School of Medicine, New (...) Circulation
  Circulation, Volume 145, Issue 22, Page 1645-1654, May 31, 2022. Background:First-generation drug-coated balloons (DCBs) have significantly reduced the rate of restenosis compared with balloon angioplasty alone; however, high rates of bailout stenting and dissections persist. The Chocolate (...) (Circulation)
• 08:00
  Fishing for Links Between Omega-3 Fatty Acids and Atrial Fibrillation - Diane Fatkin Charles D. Cox Boris Martinac Victor Chang Cardiac Research Institute, Darlinghurst, Australia (D.F., C.D.C., B.M.). St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales Sydney, Kensington, Australia (D.F., C.D.C., B.M.). Cardiology Department, St Vincent’s Hospital, Darlinghurst, Australia (D.F.). Circulation
  Circulation, Volume 145, Issue 14, Page 1037-1039, April 5, 2022. (Circulation)
• 08:00
  Letter by Belmadani and Matrougui Regarding Article, “Integrated Stress Response Couples Mitochondrial Protein Translation With Oxidative Stress Control” - Souad Belmadani Khalid Matrougui Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk. Circulation
  Circulation, Volume 145, Issue 14, Page e802-e803, April 5, 2022. (Circulation)
• 08:00
  Response by Zhang and Wang to Letter Regarding Article, “Integrated Stress Response Couples Mitochondrial Protein Translation With Oxidative Stress Control” - Guangyu Zhang Zhao V. Wang Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA. Circulation
  Circulation, Volume 145, Issue 14, Page e804-e805, April 5, 2022. (Circulation)
• 08:00
  Identification of DNA Damage Repair Enzyme Ascc2 as Causal for Heart Failure With Preserved Ejection Fraction - Yang Cao Calvin Pan Yu-Chen Wang Zhiqiang Zhou Vida Jedian Yonghong Meng Gillian Campbell Kristina Guardino Christopher Li Jessica Wang Aldons J. Lusis Department of Medicine, Division of Cardiology (Y.C., C.P., Y.-C.W., Z.Z., V.J., Y.M., J.W., A.J.L.), University of California, Los Angeles Human Genetics (A.J.L.), University of California, Los Angeles Microbiology, Immunology, and Molecular Genetics (G.C., K.G., C.L., A.J.L.), University of California, Los (...) Circulation
  Circulation, Volume 145, Issue 14, Page 1102-1104, April 5, 2022. (Circulation)
• 08:00
  Correction to: Shaping Value-Based Payment Policy: Improving Heart Health Through Value-Based Payment Circulation
  Circulation, Volume 145, Issue 14, Page e806-e806, April 5, 2022. (Circulation)
• 08:00
  What Turns the White Matter White? Metabolomic Clues to the Origin of Age-Related Cerebral White Matter Hyperintensities - Eric E. Smith Department of Clinical Neurosciences and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. Circulation
  Circulation, Volume 145, Issue 14, Page 1053-1055, April 5, 2022. (Circulation)

3 April

Circulation http://ahajournals.org/

• 06:15
  Does Timing of Ventricular Tachycardia Ablation Affect Prognosis in Patients With an Implantable Cardioverter Defibrillator? Results From the Multicenter Randomized PARTITA Trial - Paolo Della Bella Francesca Baratto Pasquale Vergara Patrizia Bertocchi Matteo Santamaria Pasquale Notarstefano Leonardo Calò Daniela Orsida Luca Tomasi Marcello Piacenti Stefano Sangiorgio Francesco Pentimalli Etienne Pruvot João De Sousa Frederic Sacher Massimo Tritto Luca Rebellato Thomas Deneke Salvo Andrea Romano Martina Nesti Alessio Gargaro Daniele Giacopelli Giovanni Peretto Andrea Radinovic Department of Cardiac Electrophysiology and Arrhythmology, San Raffaele University Hospital, Milan, Italy (P.D.B., F.B., P.V., G.P., A.R.). Cardiology Department, Ospedale di Desio, Italy (P.B., (...) Circulation
  Circulation, Volume 145, Issue 25, Page 1829-1838, June 21, 2022. Background:Optimal timing for catheter ablation of ventricular tachycardia is an important unresolved issue. There are no randomized trials evaluating the benefit of ablation after the first implantable cardioverter defibrillator (...) (Circulation)
• 14:00
  Effect of Vupanorsen on Non–High-Density Lipoprotein Cholesterol Levels in Statin-Treated Patients With Elevated Cholesterol: TRANSLATE-TIMI 70 - Brian A. Bergmark Nicholas A. Marston Candace R. Bramson Madelyn Curto Vesper Ramos Alexandra Jevne Julia F. Kuder Jeong-Gun Park Sabina A. Murphy Subodh Verma Wojtek Wojakowski Steven G. Terra Marc S. Sabatine Stephen D. Wiviott TIMI Study Group, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (B.A.B., N.A.M., A.J., J.F.K., J.-G.P., S.A.M., M.S.S., S.D.W.). Pfizer, Inc, New York, NY (C.R.B., M.C., V.R., S.G.T.). Department of Surgery, University of Toronto, Canada (S.V.). Medical University of Silesia, Katowice, Poland (W.W.)., on behalf of the TRANSLATE-TIMI 70 (...) Circulation
  Circulation, Volume 145, Issue 18, Page 1377-1386, May 3, 2022. Background:Genetic loss-of-function variants inANGPTL3are associated with lower levels of plasma lipids. Vupanorsen is a hepatically targeted antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein (...) (Circulation)

2 April

Circulation http://ahajournals.org/

• 06:00
  Quality of Life After Fractional Flow Reserve–Guided PCI Compared With Coronary Bypass Surgery - William F. Fearon Frederik M. Zimmermann Victoria Y. Ding Jo M. Zelis Zsolt Piroth Giedrius Davidavicius Samer Mansour Rajesh Kharbanda Nikolaos Östlund-Papadogeorgos Keith G. Oldroyd Olaf Wendler Michael J. Reardon Y. Joseph Woo Alan C. Yeung Nico H.J. Pijls Bernard De Bruyne Manisha Desai Mark A. Hlatky Division of Cardiovascular Medicine and Stanford Cardiovascular Institute (W.F.F., A.C.Y., M.A.H.), Stanford University, CA. Quantitative Sciences Unit (V.Y.D., M.D.), Stanford University, CA. Department of Cardiothoracic Surgery (Y.J.W.), Stanford University, CA. Department of Health (...) Circulation
  Circulation, Volume 145, Issue 22, Page 1655-1662, May 31, 2022. Background:Previous studies have shown that quality of life improves after coronary revascularization more so after coronary artery bypass grafting (CABG) than after percutaneous coronary intervention (PCI). This study aimed to (...) (Circulation)

1 April

Circulation http://ahajournals.org/

• 11:00
  Associations of Dietary Cholesterol, Serum Cholesterol, and Egg Consumption With Overall and Cause-Specific Mortality: Systematic Review and Updated Meta-Analysis - Bin Zhao Lu Gan Barry I. Graubard Satu Männistö Demetrius Albanes Jiaqi Huang National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (B.Z., L.G., J.H.). Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (B.I.G., D.A., J.H.). Department of Public Health Solutions, Finnish Institute for Health and (...) Circulation
  Circulation, Volume 145, Issue 20, Page 1506-1520, May 17, 2022. Background:Despite substantial research highlighting the importance of exogenous dietary cholesterol intake and endogenous serum cholesterol level in human health, a thorough evaluation of the associations is lacking. Our study (...) (Circulation)
• 08:00
  2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines - Paul A. Heidenreich Biykem Bozkurt David Aguilar Larry A. Allen Joni J. Byun Monica M. Colvin Anita Deswal Mark H. Drazner Shannon M. Dunlay Linda R. Evers James C. Fang Savitri E. Fedson Gregg C. Fonarow Salim S. Hayek Adrian F. Hernandez Prateeti Khazanie Michelle M. Kittleson Christopher S. Lee Mark S. Link Carmelo A. Milano Lorraine C. Nnacheta Alexander T. Sandhu Lynne Warner Stevenson Orly Vardeny Amanda R. Vest Clyde W. Yancy *Writing committee members are required to recuse themselves from voting on sections to which their specific relationships with industry may apply; see (...) Circulation
  Circulation, Volume 145, Issue 18, Page e876-e894, May 3, 2022. Aim:The “2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure” replaces the “2013 ACCF/AHA Guideline for the Management of Heart Failure” and the “2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the (...) (Circulation)
• 08:00
  2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines - Paul A. Heidenreich Biykem Bozkurt David Aguilar Larry A. Allen Joni J. Byun Monica M. Colvin Anita Deswal Mark H. Drazner Shannon M. Dunlay Linda R. Evers James C. Fang Savitri E. Fedson Gregg C. Fonarow Salim S. Hayek Adrian F. Hernandez Prateeti Khazanie Michelle M. Kittleson Christopher S. Lee Mark S. Link Carmelo A. Milano Lorraine C. Nnacheta Alexander T. Sandhu Lynne Warner Stevenson Orly Vardeny Amanda R. Vest Clyde W. Yancy *Writing committee members are required to recuse themselves from voting on sections to which their specific relationships with industry may apply; see (...) Circulation
  Circulation, Volume 145, Issue 18, Page e895-e1032, May 3, 2022. Aim:The “2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure” replaces the “2013 ACCF/AHA Guideline for the Management of Heart Failure” and the “2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the (...) (Circulation)
• 08:00
  Updated Heart Failure Guidelines: Time for a Refresh - Alanna A. Morris Javed Butler Division of Cardiology, Emory University, Atlanta, GA (A.A.M.). Baylor Scott and White Research Institute, Baylor Scott and White Health, Dallas, TX (J.B.). Circulation
  Circulation, Volume 145, Issue 18, Page 1371-1373, May 3, 2022. (Circulation)

31 March

Circulation http://ahajournals.org/

• 11:00
  Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure - Barry A. Borlaug John Blair Martin W. Bergmann Heiko Bugger Dan Burkhoff Leonhard Bruch David S. Celermajer Brian Claggett John G.F. Cleland Donald E. Cutlip Ira Dauber Jean-Christophe Eicher Qi Gao Thomas M. Gorter Finn Gustafsson Chris Hayward Jan van der Heyden Gerd Hasenfuß Scott L. Hummel David M. Kaye Jan Komtebedde Joseph M. Massaro Jeremy A. Mazurek Scott McKenzie Shamir R. Mehta Mark C. Petrie Marco C. Post Ajith Nair Andreas Rieth Frank E. Silvestry Scott D. Solomon Jean-Noël Trochu Dirk J. Van Veldhuisen Ralf Westenfeld Martin B. Leon Sanjiv J. Shah Department of Cardiovascular (...) Circulation
  Circulation, Volume 145, Issue 21, Page 1592-1604, May 24, 2022. Background:In REDUCE LAP-HF II (A Study to Evaluate the Corvia Medical, Inc IASD System II to Reduce Elevated Left Atrial Pressure in Patients With Heart Failure), implantation of an atrial shunt device did not provide overall (...) (Circulation)

28 March

Circulation http://ahajournals.org/

• 11:00
  Coronary Artery and Cardiac Disease in Patients With Type 2 Myocardial Infarction: A Prospective Cohort Study - Anda Bularga John Hung Marwa Daghem Stacey Stewart Caelan Taggart Ryan Wereski Trisha Singh Mohammed N. Meah Takeshi Fujisawa Amy V. Ferry Justin Chiong William S. Jenkins Fiona E. Strachan Scott Semple Edwin J.R. van Beek Michelle Williams Damini Dey Chris Tuck Andrew H. Baker David E. Newby Marc R. Dweck Nicholas L. Mills Andrew R. Chapman BHF Centre for Cardiovascular Science (A.B., J.H., M.D., S.S., C.T., R.W., T.S., M.N.M., T.F., A.V.F., J.C., W.S.J., F.E.S., M.W., C.T., A.H.B., D.E.N., M.R.D., N.L.M., A.R.C.), University of Edinburgh, United Kingdom. Edinburgh Imaging (S.S., (...) Circulation
  Circulation, Volume 145, Issue 16, Page 1188-1200, April 19, 2022. Background:Type 2 myocardial infarction is caused by myocardial oxygen supply-demand imbalance, and its diagnosis is increasingly common with the advent of high-sensitivity cardiac troponin assays. Although this diagnosis is (...) (Circulation)
• 08:00
  A Tachycardia in Disguise - Giacomo Mugnai Alessia Gambaro Flavio Luciano Ribichini Division of Cardiology, Department of Medicine, School of Medicine, University of Verona, Verona, Italy. Circulation
  Circulation, Volume 145, Issue 13, Page 1024-1028, March 29, 2022. (Circulation)
• 08:00
  Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications - Trisha Singh Hilal Khan David T. Gamble Caroline Scally David E. Newby Dana Dawson British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (T.S., C.S., D.E.N.). Aberdeen Cardiovascular and Diabetes Centre, University of Aberdeen, United Kingdom (H.K., D.T.G., D.D.). Circulation
  Circulation, Volume 145, Issue 13, Page 1002-1019, March 29, 2022. Takotsubo syndrome is a condition characterized by acute transient left ventricular systolic dysfunction, which at presentation can be challenging to distinguish from acute myocardial infarction. Although previously thought to (...) (Circulation)
• 08:00
  Equipoise in Clinical Trials: Enough Uncertainty in Whose Opinion? - John H. Alexander Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC. Circulation
  Circulation, Volume 145, Issue 13, Page 943-945, March 29, 2022. (Circulation)
• 08:00
  Empagliflozin Reverses Late Na+ Current Enhancement and Cardiomyocyte Proarrhythmia in a Translational Murine Model of Heart Failure With Preserved Ejection Fraction - Bence Hegyi Juliana Mira Hernandez Erin Y. Shen Nima R. Habibi Julie Bossuyt Donald M. Bers Department of Pharmacology, University of California, Davis (B.H., J.M.H., E.Y.S., N.R.H., J.B., D.M.B.). Research Group in Veterinary Medicine (GIVET), School of Veterinary Medicine, University Corporation Lasallista (Unilasallista), Caldas, Antioquia, Colombia (J.M.H.). Circulation
  Circulation, Volume 145, Issue 13, Page 1029-1031, March 29, 2022. (Circulation)
• 08:00
  Activation of iNKT Cells at the Maternal–Fetal Interface Predisposes Offspring to Cardiac Injury - Dayan Cao Ying Liu Xin Chen Jie Liu Jie Liu Wenjing Lai Shuhui Li Wenjia Wang Wenjun Zhang Deyong Xiao Kai Yang Baiyan Li Zhongjun Zhou Chen-Leng Cai Xiaohui Li Weinian Shou Institute of Materia Medica and Center of Translational Medicine (D.C., J.L., J.L., X.C., W.W., X.L.), Army Medical University, Chongqing, China. Department of Pharmacy, Xinqiao Hospital (W.L.), Army Medical University, Chongqing, China. Department of Clinical Biochemistry, College of Pharmacy (S.L.), Army Medical University, Chongqing, China. Herman B Wells Center for Pediatric Research, Department of Pediatrics, (...) Circulation
  Circulation, Volume 145, Issue 13, Page 1032-1035, March 29, 2022. (Circulation)
• 08:00
  Higher Risk of Heart Disease Among South Asians Calls for Targeted Interventions - Bridget M. Kuehn Circulation
  Circulation, Volume 145, Issue 13, Page 1020-1021, March 29, 2022. (Circulation)
• 08:00
  From the Literature - Tracy Hampton Circulation
  Circulation, Volume 145, Issue 13, Page 1022-1023, March 29, 2022. (Circulation)
• 08:00
  Atrial Fibrillation Screening: The Tools Are Ready, But Should We Do It? - Fabrice Extramiana Philippe Gabriel Steg Université de Paris, INSERM-1148, France (P.G.S.). Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, France (F.E., P.G.S.). French Alliance for Cardiovascular Trials, Paris, France (P.G.S.). Imperial College, Royal Brompton Hospital, London, UK (P.G.S.). Circulation
  Circulation, Volume 145, Issue 13, Page 955-958, March 29, 2022. (Circulation)
• 08:00
  Insulin and Bile Acids in Cholesterol Homeostasis: New Players in Diabetes-Associated Atherosclerosis - Víctor Cortés Robert H. Eckel Department of Nutrition, Diabetes and Metabolism, Pontificia Universidad Católica de Chile, Santiago (V.C.). Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, (R.H.E.). Circulation
  Circulation, Volume 145, Issue 13, Page 983-986, March 29, 2022. (Circulation)

23 March

Circulation http://ahajournals.org/

• 10:00
  Novel CaMKII-? Inhibitor Hesperadin Exerts Dual Functions to Ameliorate Cardiac Ischemia/Reperfusion Injury and Inhibit Tumor Growth - Junxia Zhang Ruqi Liang Kai Wang Wenjia Zhang Mao Zhang Li Jin Peng Xie Wen Zheng Haibao Shang Qingmei Hu Jiayi Li Gengjia Chen Fujian Wu Feng Lan Lipeng Wang Shi-Qiang Wang Yongfeng Li Yong Zhang Jinghao Liu Fengxiang Lv Xinli Hu Rui-Ping Xiao Xiaoguang Lei Yan Zhang State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, College of Future Technology (J.Z., M.Z., L.J., P.X., W. Zheng, H.S., Q.H., J. Li, G.C., J. Liu, F.L., X.H., R.-P.X., Yan Zhang), Peking University, Beijing, China. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic (...) Circulation
  Circulation, Volume 145, Issue 15, Page 1154-1168, April 12, 2022. Background:Cardiac ischemia/reperfusion (I/R) injury has emerged as an important therapeutic target for ischemic heart disease, the leading cause of morbidity and mortality worldwide. At present, there is no effective therapy (...) (Circulation)

22 March

Circulation http://ahajournals.org/

• 10:00
  Randomized Ablation-Based Rhythm-Control Versus Rate-Control Trial in Patients With Heart Failure and Atrial Fibrillation: Results from the RAFT-AF trial - Ratika Parkash George A. Wells Jean Rouleau Mario Talajic Vidal Essebag Allan Skanes Stephen B. Wilton Atul Verma Jeffrey S. Healey Laurence Sterns Matthew Bennett Jean-Francois Roux Lena Rivard Peter Leong-Sit Mats Jensen-Urstad Umjeet Jolly Francois Philippon John L. Sapp Anthony S.L. Tang Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada (R.P., J.L.S.). University of Ottawa Cardiovascular Research Methods Centre, Ontario, Canada (G.A.W.). Montréal Heart Institute, Université de Montréal, Québec, Canada (J.R., M.T., L.R.). McGill University Health Centre, Montreal, (...) Circulation
  Circulation, Volume 145, Issue 23, Page 1693-1704, June 7, 2022. Background:Atrial fibrillation (AF) and heart failure (HF) frequently coexist and can be challenging to treat. Pharmacologically based rhythm control of AF has not proven to be superior to rate control. Ablation-based rhythm (...) (Circulation)

21 March

Circulation http://ahajournals.org/

• 13:00
  Cost-Effectiveness of a Household Salt Substitution Intervention: Findings From 20 995 Participants of the Salt Substitute and Stroke Study - Ka-Chun Li Liping Huang Maoyi Tian Gian Luca Di Tanna Jie Yu Xinyi Zhang Xuejun Yin Yishu Liu Zhixin Hao Bo Zhou Xiangxian Feng Zhifang Li Jianxin Zhang Jixin Sun Yuhong Zhang Yi Zhao Ruijuan Zhang Yan Yu Nicole Li Lijing L. Yan Darwin R. Labarthe Paul Elliott Yangfeng Wu Bruce Neal Thomas Lung Lei Si The George Institute for Global Health, University of New South Wales, Sydney, Australia (K.-C.L., L.H., M.T., G.L.D.T., J.Y., X.Y., Y.L., N.L., B.N., T.L., L.S.). School of Public Health, Harbin Medical University, China (M.T.). Department of Cardiology, Peking University Third Hospital, (...) Circulation
  Circulation, Volume 145, Issue 20, Page 1534-1541, May 17, 2022. Background:SSaSS (Salt Substitute and Stroke Study), a 5-year cluster randomized controlled trial, demonstrated that replacing regular salt with a reduced-sodium, added-potassium salt substitute reduced the risks of stroke, major (...) (Circulation)
• 08:00
  Understanding the Importance of the Lay Responder Experience in Out-of-Hospital Cardiac Arrest: A Scientific Statement From the American Heart Association - Katie N. Dainty Brianna Colquitt Farhan Bhanji Elizabeth A. Hunt Tiffany Jefkins Marion Leary Joseph P. Ornato Robert A. Swor Ashish Panchal Circulation
  Circulation, Volume 145, Issue 17, Page e852-e867, April 26, 2022. Bystander cardiopulmonary resuscitation (CPR) is critical to increasing survival from out-of-hospital cardiac arrest. However, the percentage of cases in which an individual receives bystander CPR is actually low, at only 35% to (...) (Circulation)
• 07:00
  Hemophagocytic Lymphohistiocytosis Associated With Endocarditis: A Case Years in the Making - Vanessa Blumer Joshua B. Parsons D. Ryan Anderson Gerald S. Bloomfield Cary Ward Division of Cardiology, Department of Medicine (V.B., G.S.B., C.W.), Duke University Medical Center, Durham, NC. Division of Infectious Diseases, Department of Medicine (J.B.P.), Duke University Medical Center, Durham, NC. Division of Rheumatology, Department of Medicine (D.R.A.), Duke University Medical Center, Durham, NC. Duke Clinical Research Institute, Durham, NC (V.B., (...) Circulation
  Circulation, Volume 145, Issue 12, Page 934-939, March 22, 2022. (Circulation)
• 07:00
  Is Asymptomatic Severe Aortic Stenosis Still a Waiting Game? - Graham S. Hillis Gerry P. McCann David E. Newby Department of Cardiology, Royal Perth Hospital and Medical School, University of Western Australia, Perth (G.S.H.). Department of Cardiovascular Sciences, University of Leicester and the NIHR Leicester Biomedical Research Centre, Glenfield Hospital, United Kingdom (G.P.M.). British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (D.E.N.). Circulation
  Circulation, Volume 145, Issue 12, Page 874-876, March 22, 2022. (Circulation)
• 07:00
  Letter by Ng et al Regarding Article, “Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial” - Chi Fai Ng Jeremy Y.C. Teoh Peter K.F. Chiu The Chinese University of Hong Kong, China. Circulation
  Circulation, Volume 145, Issue 12, Page e773-e774, March 22, 2022. (Circulation)
• 07:00
  Inherited Thrombophilias Are Associated With a Higher Risk of COVID-19–Associated Venous Thromboembolism: A Prospective Population-Based Cohort Study - Hannah Stevens Rodrigo Canovas Huyen Tran Karlheinz Peter James D. McFadyen Department of Haematology (H.S., H.T., J.M.), Alfred Hospital, Melbourne, Victoria, Australia. Department of Cardiology (K.P.), Alfred Hospital, Melbourne, Victoria, Australia. Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia (H.S., H.T., J.M.). Atherothrombosis and Vascular Biology Program (H.S., K.P., J.M.), Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia. Cambridge Baker Systems Genomics Initiative (R.C.), Baker Heart and Diabetes Institute, Melbourne, (...) Circulation
  Circulation, Volume 145, Issue 12, Page 940-942, March 22, 2022. (Circulation)
• 07:00
  Correction to: Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association Circulation
  Circulation, Volume 145, Issue 12, Page e775-e775, March 22, 2022. (Circulation)
• 07:00
  First Steps of Population Genomic Medicine in the Arrhythmia World: Pros and Cons - Roddy Walsh Connie Bezzina Arthur A.M. Wilde Amsterdam University Medical Centres, University of Amsterdam, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands (R.W., C.B., A.A.M.W.). European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart) (C.B., A.A.M.W.). Circulation
  Circulation, Volume 145, Issue 12, Page 892-895, March 22, 2022. (Circulation)

18 March

Circulation http://ahajournals.org/

• 10:00
  Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization - Albert Henry María Gordillo-Marañón Chris Finan Amand F. Schmidt João Pedro Ferreira Ravi Karra Johan Sundström Lars Lind Johan Ärnlöv Faiez Zannad Anders Mälarstig Aroon D. Hingorani R. Thomas Lumbers Institute of Cardiovascular Science (A.H., M.G.-M., C.F., A.F.S., A.D.H.), University College London, United Kingdom. British Heart Foundation Research Accelerator (A.H., M.G.-M., C.F., A.F.S., A.D.H., R.T.L.), University College London, United Kingdom. Institute of Health Informatics (A.H., R.T.L.), University College London, United Kingdom. Health Data Research UK London (R.T.L.), University (...) Circulation
  Circulation, Volume 145, Issue 16, Page 1205-1217, April 19, 2022. Background:Heart failure (HF) is a highly prevalent disorder for which disease mechanisms are incompletely understood. The discovery of disease-associated proteins with causal genetic evidence provides an opportunity to identify (...) (Circulation)

17 March

Circulation http://ahajournals.org/

• 10:00
  MicroRNA-210 Controls Mitochondrial Metabolism and Protects Heart Function in Myocardial Infarction - Rui Song Chiranjib Dasgupta Cassidy Mulder Lubo Zhang Lawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, CA. Circulation
  Circulation, Volume 145, Issue 15, Page 1140-1153, April 12, 2022. Background:Ischemic heart disease remains a leading cause of death worldwide. In this study, we test the hypothesis that microRNA-210 protects the heart from myocardial ischemia-reperfusion (IR) injury by controlling (...) (Circulation)

14 March

Circulation http://ahajournals.org/

• 11:00
  Age and Racial/Ethnic Disparities in Pediatric Out-of-Hospital Cardiac Arrest - Aditya C. Shekhar Teri Campbell N. Clay Mann Ira J. Blumen Manu Madhok Center for Bioethics, Harvard Medical School, Boston, MA (A.C.S.). University of Minnesota-Twin Cities (A.C.S., M.M.), Minneapolis. Department of Emergency Medicine, Children’s Minnesota (M.M.), Minneapolis. University of Chicago Aeromedical Network (T.C., I.J.B.), University of Chicago, IL. Department of Emergency Medicine (I.J.B.)., University of Chicago, IL. Department of Pediatrics, University of Utah School of Medicine, Salt Lake City (...) Circulation
  Circulation, Volume 145, Issue 16, Page 1288-1289, April 19, 2022. (Circulation)
• 07:00
  Curious ECG Morphology of a Cardiac Device: A New Normal? - Caroline E. Murphy Kyle D. Bartol John G. Symons Department of Cardiology, Walter Reed National Military Medical Center, Bethesda, MD. Circulation
  Circulation, Volume 145, Issue 11, Page 864-867, March 15, 2022. (Circulation)
• 07:00
  Clinical Trial Design Principles and Outcomes Definitions for Device-Based Therapies for Hypertension: A Consensus Document From the Hypertension Academic Research Consortium - David E. Kandzari Felix Mahfoud Michael A. Weber Raymond Townsend Gianfranco Parati Naomi D.L. Fisher Melvin D. Lobo Michael Bloch Michael Böhm Andrew S.P. Sharp Roland E. Schmieder Michel Azizi Markus P. Schlaich Vasilios Papademetriou Ajay J. Kirtane Joost Daemen Atul Pathak Christian Ukena Philipp Lurz Guido Grassi Martin Myers Aloke V. Finn Marie-Claude Morice Roxana Mehran Peter Jüni Gregg W. Stone Mitchell W. Krucoff Paul K. Whelton Konstantinos Tsioufis Donald E. Cutlip Ernest Spitzer Piedmont Heart Institute, Atlanta, GA (D.E.K.). Klinik für Innere Medizin III, Kardiologie, (...) Circulation
  Circulation, Volume 145, Issue 11, Page 847-863, March 15, 2022. The clinical implications of hypertension in addition to a high prevalence of both uncontrolled blood pressure and medication nonadherence promote interest in developing device-based approaches to hypertension treatment. The (...) (Circulation)
• 07:00
  Sublingual Nitrates for Patients as a Default in the Post-ACS Discharge Pack: Is It Time for a Rethink? - Avedis A. Ekmejian Ravinay Bhindi Gemma A. Figtree Department of Cardiology, Royal North Shore Hospital, Sydney, Australia (A.A.E., R.B., G.A.F.). Cardiovascular Discovery Group, Kolling Institute of Medical Research (R.B., G.A.F.), University of Sydney, Australia. Charles Perkins Centre (G.A.F.), University of Sydney, Australia. Circulation
  Circulation, Volume 145, Issue 11, Page 791-792, March 15, 2022. (Circulation)
• 07:00
  Myocardial Edema Provides a Link Between Pulmonary Arterial Hypertension and Pericardial Effusion - Randolph H. Stewart Charles S. Cox Steven J. Allen Glen A. Laine Michael E. DeBakey Institute (R.H.S., C.S.C., S.J.A., G.A.L), Texas A&M University, College Station. Department of Veterinary Physiology and Pharmacology (R.H.S.), Texas A&M University, College Station. McGovern Medical School at UTHealth, University of Texas Health Science Center at Houston (C.S.C.). Circulation
  Circulation, Volume 145, Issue 11, Page 793-795, March 15, 2022. (Circulation)
• 07:00
  Letter by Feng and Nie Regarding Article, “Myeloid-Derived Growth Factor Protects Against Pressure Overload-Induced Heart Failure” - Jie Feng Yu Nie State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing. Circulation
  Circulation, Volume 145, Issue 11, Page e768-e769, March 15, 2022. (Circulation)
• 07:00
  Response by Wollert to Letter Regarding Article, “Myeloid-Derived Growth Factor Protects Against Pressure Overload-Induced Heart Failure” - Kai C. Wollert Division of Molecular and Tanslational Cardiology, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany. Circulation
  Circulation, Volume 145, Issue 11, Page e770-e770, March 15, 2022. (Circulation)
• 07:00
  Shaping Value-Based Payment Policy: Improving Heart Health Through Value-Based Payment - Keith Churchwell Donald M. Lloyd-Jones Melanie Phelps Yale New Haven Hospital, New Haven, CT (K.C.). Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (D.M.L.-J.). American Heart Association, Dallas, TX (M.P.). Circulation
  Circulation, Volume 145, Issue 11, Page e765-e767, March 15, 2022. (Circulation)
• 07:00
  Correction to: 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines Circulation
  Circulation, Volume 145, Issue 11, Page e771-e771, March 15, 2022. (Circulation)
• 07:00
  Correction to: 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines Circulation
  Circulation, Volume 145, Issue 11, Page e772-e772, March 15, 2022. (Circulation)
• 07:00
  Atrial Fibrillation Ablation: Aiming to Improve Quantity and Quality of Life - Jason G. Andrade Laurent Macle University of British Columbia, Vancouver, Canada (J.G.A.). Center for Cardiovascular Innovation, Vancouver, Canada (J.G.A.). Montreal Heart Institute, Université de Montréal, Canada (J.G.A., L.M.). Circulation
  Circulation, Volume 145, Issue 11, Page 805-807, March 15, 2022. (Circulation)

9 March

Circulation http://ahajournals.org/

• 11:00
  Comprehensive Quality-of-Life Outcomes With Invasive Versus Conservative Management of Chronic Coronary Disease in ISCHEMIA - Daniel B. Mark John A. Spertus Robert Bigelow Sophia Anderson Melanie R. Daniels Kevin J. Anstrom Khaula N. Baloch David J. Cohen Claes Held Shaun G. Goodman Sripal Bangalore Derek Cyr Harmony R. Reynolds Karen P. Alexander Yves Rosenberg Gregg W. Stone David J. Maron Judith S. Hochman Duke Clinical Research Institute, Duke University, Durham, NC (D.B.M., R.B., S.A., M.R.D., K.J.A., K.N.B., D.C., K.P.A.). Saint Luke’s Mid America Heart Institute/University of Missouri, Kansas City (J.A.S.). Cardiovascular Research Foundation, New York (D.J.C.). St. Francis Hospital and Heart Center, (...) Circulation
  Circulation, Volume 145, Issue 17, Page 1294-1307, April 26, 2022. Background:ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) compared an initial invasive treatment strategy (INV) with an initial conservative strategy in 5179 participants (...) (Circulation)

7 March

Circulation http://ahajournals.org/

• 11:00
  Beyond 10-Year Risk: A Cost-Effectiveness Analysis of Statins for the Primary Prevention of Cardiovascular Disease - Ciaran N. Kohli-Lynch James Lewsey Kathleen A. Boyd Dustin D. French Neil Jordan Andrew E. Moran Naveed Sattar David Preiss Andrew H. Briggs Center for Health Services and Outcomes Research (C.N.K.-L., D.D.F., N.J.), Feinberg School of Medicine, Northwestern University, Chicago, IL. Departments of Ophthalmology and Medical Social Science (D.D.F.), Feinberg School of Medicine, Northwestern University, Chicago, IL. Psychiatry & Behavioral Sciences and Preventive Medicine (N.J.), Feinberg School of Medicine, Northwestern University, Chicago, IL. Health Economics and Health Technology (...) Circulation
  Circulation, Volume 145, Issue 17, Page 1312-1323, April 26, 2022. Background:Cholesterol guidelines typically prioritize primary prevention statin therapy on the basis of 10-year risk of cardiovascular disease. The advent of generic pricing may justify expansion of statin eligibility. (...) (Circulation)
• 11:01
  Critical Illness Among Patients Hospitalized With Acute COVID-19 With and Without Congenital Heart Defects - Karrie F. Downing Regina M. Simeone Matthew E. Oster Sherry L. Farr Centers for Disease Control and Prevention COVID-19 Response Team, Atlanta, GA (K.F.D., R.M.S.). National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA (K.F.D., M.E.O., S.L.F.). Children’s Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA (M.E.O.). Circulation
  Circulation, Volume 145, Issue 15, Page 1182-1184, April 12, 2022. (Circulation)
• 11:00
  Cardio-Oncology Drug Interactions: A Scientific Statement From the American Heart Association - Craig J. Beavers Jo E. Rodgers Aaron J. Bagnola Theresa M. Beckie Umberto Campia Katherine E. Di Palo Tochi M. Okwuosa Eugene R. Przespolewski Susan Dent Circulation
  Circulation, Volume 145, Issue 15, Page e811-e838, April 12, 2022. In the cardio-oncology population, drug interactions are of particular importance given the complex pharmacological profile, narrow therapeutic index, and inherent risk of therapies used to manage cardiovascular disease and (...) (Circulation)
• 08:00
  Rare Case of Wide QRS Tachycardia After Sintilimab Treatment for Lung Cancer - Yi Tang Yi Zhang Xiao-Yan Yang Department of Cardiology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Clinical Medicine Research Center of Heart Failure of Hunan Province, Hunan Normal University, Changsha, China. Circulation
  Circulation, Volume 145, Issue 10, Page 783-786, March 8, 2022. (Circulation)
• 08:00
  CYP2C19 Genotyping in Anticoagulated Patients After Percutaneous Coronary Intervention: Should It Be Routine? - Dimitri J. Maamari Farouc A. Jaffer Amit V. Khera Akl C. Fahed Center for Genomic Medicine (D.J.M., A.V.K., A.C.F.), Massachusetts General Hospital Division of Cardiology (F.A.J., A.V.K., A.C.F.), Department of Medicine, Massachusetts General Hospital Cardiovascular Research Center, Cardiology Division (F.A.J., A.C.F.), Massachusetts General Hospital Department of Medicine, Harvard Medical School (F.A.J., A.V.K., A.C.F.) Boston. Cardiovascular Disease Initiative, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge (D.J.M., A.V.K., (...) Circulation
  Circulation, Volume 145, Issue 10, Page 721-723, March 8, 2022. (Circulation)
• 08:00
  Letter by Nagareddy and Sreejit Regarding Article, “Interleukin-1? Is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease” - Prabhakara R. Nagareddy Gopalkrishna Sreejit Division of Cardiac Surgery, Department of Surgery, Ohio State University Wexner Medical Center, Columbus. Circulation
  Circulation, Volume 145, Issue 10, Page e762-e763, March 8, 2022. (Circulation)
• 08:00
  Response by Schunk and Speer to the Letter Regarding Article, “Interleukin-1? Is a Central Regulator of Leukocyte-Endothelial Adhesion in Myocardial Infarction and in Chronic Kidney Disease” - Stefan J. Schunk Thimoteus Speer Department of Internal Medicine IV, Nephrology and Hypertension (S.J.S., T.S.), Saarland University, Homburg/Saar, Germany. Translational Cardio-Renal Medicine (T.S.), Saarland University, Homburg/Saar, Germany. Circulation
  Circulation, Volume 145, Issue 10, Page e764-e764, March 8, 2022. (Circulation)
• 08:00
  Efficient In Vivo Homology-Directed Repair Within Cardiomyocytes - Yanjiang Zheng Nathan J. VanDusen Catalina E. Butler Qing Ma Justin S. King William T. Pu Department of Biochemistry, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China (Y.Z.). Department of Cardiology, Boston Children’s Hospital, MA (Y.Z., N.J.V., C.E.B., Q.M., J.S.K., W.T.P.). Harvard Stem Cell Institute, Cambridge, MA (W.T.P.). Circulation
  Circulation, Volume 145, Issue 10, Page 787-789, March 8, 2022. (Circulation)
• 08:00
  Are 2 Left Atrial Appendage Guards Better Than 1? The Amulet IDE Randomized Trial - Christopher Kowalewski Nikolaos Dagres Gerhard Hindricks Heart Center Leipzig at University Leipzig, Department of Cardiology and Electrophysiology, HELIOS Kliniken GmbH, Leipzig, Germany. Circulation
  Circulation, Volume 145, Issue 10, Page 739-741, March 8, 2022. (Circulation)

3 March

Circulation http://ahajournals.org/

• 11:00
  Heteroplasmy of Wild-Type Mitochondrial DNA Variants in Mice Causes Metabolic Heart Disease With Pulmonary Hypertension and Frailty - Ana Victoria Lechuga-Vieco Ana Latorre-Pellicer Enrique Calvo Carlos Torroja Juan Pellico Rebeca Acín-Pérez María Luisa García-Gil Arnoldo Santos Navratan Bagwan Elena Bonzon-Kulichenko Ricardo Magni Marina Benito Raquel Justo-Méndez Anna Katharina Simon Fátima Sánchez-Cabo Jesús Vázquez Jesús Ruíz-Cabello José Antonio Enríquez Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain (A.V.L.-V., R.M., M.B., R.J.-M., J.R.-C.). The Kennedy Institute of Rheumatology, NDORMS, University of Oxford, UK (A.V.L.-V., A.K.S.). Ciber de Enfermedades Respiratorias (CIBERES), Madrid, Spain (...) Circulation
  Circulation, Volume 145, Issue 14, Page 1084-1101, April 5, 2022. Background:In most eukaryotic cells, the mitochondrial DNA (mtDNA) is transmitted uniparentally and present in multiple copies derived from the clonal expansion of maternally inherited mtDNA. All copies are therefore (...) (Circulation)

2 March

Circulation http://ahajournals.org/

• 11:00
  Screening for Atrial Fibrillation in Older Adults at Primary Care Visits: VITAL-AF Randomized Controlled Trial - Steven A. Lubitz Steven J. Atlas Jeffrey M. Ashburner Ana T. Trisini Lipsanopoulos Leila H. Borowsky Wyliena Guan Shaan Khurshid Patrick T. Ellinor Yuchiao Chang David D. McManus Daniel E. Singer Demoulas Center for Cardiac Arrhythmias and Cardiovascular Research Center (S.A.L., S.K., P.T.E.), Massachusetts General Hospital, Boston. Division of General Internal Medicine (S.J.A., J.M.A., L.H.B., Y.C., D.E.S.), Massachusetts General Hospital, Boston. Division of Cardiology (A.T.T.L.), Massachusetts General Hospital, Boston. Harvard Medical School, Boston, MA (S.A.L., J.M.A., S.K., P.T.E., (...) Circulation
  Circulation, Volume 145, Issue 13, Page 946-954, March 29, 2022. Background:Undiagnosed atrial fibrillation (AF) may cause preventable strokes. Guidelines differ regarding AF screening recommendations. We tested whether point-of-care screening with a handheld single-lead ECG at primary care (...) (Circulation)
• 06:17
  DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics - Lingfang Zhuang Kangni Jia Chen Chen Zhigang Li Jiaxin Zhao Jian Hu Hang Zhang Qin Fan Chunkai Huang Hongyang Xie Lin Lu Weifeng Shen Guang Ning Jiqiu Wang Ruiyan Zhang Kang Chen Xiaoxiang Yan Department of Cardiovascular Medicine (L.Z., K..J., Z.L., J.Z., J.H., H.Z., Q.F., C.H., H.X., L.L., W.S., R.Z., K.C., X.Y.), Shanghai Jiao Tong University School of Medicine, Shanghai, PR China. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases (G.N., J.W.), Shanghai Jiao Tong University School of Medicine, Shanghai, PR China. Ruijin Hospital, (...) Circulation
  Circulation, Volume 145, Issue 11, Page 829-846, March 15, 2022. Background:Heart failure is a global public health issue that is associated with increasing morbidity and mortality. Previous studies have suggested that mitochondrial dysfunction plays critical roles in the progression of heart (...) (Circulation)

28 February

Circulation http://ahajournals.org/

• 08:00
  Heart of Gold: A Scintillating Pericardial Effusion - Lee Bockus Kenta Nakamura Michael Chen University of Washington Medical Center (L.B., K.N.), University of Washington Division of Cardiology, Seattle. Harborview Medical Center (K.N., M.C.), University of Washington Division of Cardiology, Seattle. Circulation
  Circulation, Volume 145, Issue 9, Page 713-717, March 1, 2022. (Circulation)
• 08:00
  Evidence-Based Medical Therapy in Patients With Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease - Iris E. Beldhuis Carolyn S.P. Lam Jeffrey M. Testani Adriaan A. Voors Harriette G.C. Van Spall Jozine M. ter Maaten Kevin Damman University of Groningen, Department of Cardiology, University Medical Center Groningen, The Netherlands (I.E.B., C.S.P.L., A.A.V., J.M.t.M., K.D.). National Heart Centre Singapore and Duke-National University of Singapore (C.S.P.L.). Department of Internal Medicine, Section of Cardiology, Yale University School of Medicine, New Haven, CT (J.M.T.). Department of Medicine (H.G.C.V.S.), McMaster University, Hamilton, Canada. Department of Health Research Methods, (...) Circulation
  Circulation, Volume 145, Issue 9, Page 693-712, March 1, 2022. Chronic kidney disease (CKD) as identified by a reduced estimated glomerular filtration rate (eGFR) is a common comorbidity in patients with heart failure with reduced ejection fraction (HFrEF). The presence of CKD is associated (...) (Circulation)
• 08:00
  What Are Adaptive Platform Clinical Trials and What Role May They Have in Cardiovascular Medicine? - Patrick R. Lawler Judith S. Hochman Ryan Zarychanski Peter Munk Cardiac Centre, Toronto General Hospital, Canada (P.R.L.). Division of Cardiology and Interdepartmental Division of Critical Care Medicine, University of Toronto, Canada (P.R.L.). Cardiovascular Clinical Research Center and Division of Cardiology, New York University Langone Health, New York University Grossman School of Medicine (J.S.H.). University of Manitoba, Max Rady College of Medicine, Department of Internal Medicine, Sections of Hematology/Medical Oncology and Critical Care, Winnipeg, Canada (R.Z). CancerCare (...) Circulation
  Circulation, Volume 145, Issue 9, Page 629-632, March 1, 2022. (Circulation)
• 08:00
  Letter by Lucas and Taegtmeyer Regarding Article, “One-Year Committed Exercise Training Reverses Abnormal Left Ventricular Myocardial Stiffness in Patients With Stage B Heart Failure With Preserved Ejection Fraction” - Claire Huang Lucas Heinrich Taegtmeyer Division of Cardiology, Department of Internal Medicine, McGovern Medical School at the University of Texas Health Science Center at Houston. Circulation
  Circulation, Volume 145, Issue 9, Page e642-e643, March 1, 2022. (Circulation)
• 08:00
  Response by Hieda and Levine to Letter Regarding Article, “One-Year Committed Exercise Training Reverses Abnormal Left Ventricular Myocardial Stiffness in Patients With Stage B Heart Failure With Preserved Ejection Fraction” - Michinari Hieda Benjamin D. Levine Department of Medicine and Biosystemic Science, Hematology, Oncology, and Cardiovascular Medicine, School of Medicine, Kyushu University, Fukuoka, Japan (M.H.). Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas (B.D.L.). University of Texas Southwestern Medical Center, Dallas (B.D.L.). Circulation
  Circulation, Volume 145, Issue 9, Page e644-e644, March 1, 2022. (Circulation)
• 08:00
  Efficacy and Safety of Edoxaban 15 mg According to Renal Function in Very Elderly Patients With Atrial Fibrillation: A Subanalysis of the ELDERCARE-AF Trial - Tetsuro Yoshida Akihiro Nakamura Junichi Funada Mari Amino Wataru Shimizu Masayuki Fukuzawa Saori Watanabe Takuya Hayashi Takeshi Yamashita Ken Okumura Masaharu Akao Department of Cardiovascular Medicine, Onga Nakama Medical Association Onga Hospital, Japan (T. Yoshida). Department of Cardiology, Iwate Prefectural Central Hospital, Morioka, Japan (A.N.). Department of Cardiology, National Hospital Organization Ehime Medical Center, Toon, Japan (J.F.). Department of Cardiology, Tokai University, Isehara, Japan (M.A.). Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, (...) Circulation
  Circulation, Volume 145, Issue 9, Page 718-720, March 1, 2022. (Circulation)
• 08:00
  Correction to: 2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Neonatal Life Support; Education, Implementation, and Teams; First Aid Task Forces; and the COVID-19 Working Group Circulation
  Circulation, Volume 145, Issue 9, Page e760-e760, March 1, 2022. (Circulation)
• 08:00
  Correction to: Aortic Valve Replacement Versus Conservative Treatment in Asymptomatic Severe Aortic Stenosis: The AVATAR Trial Circulation
  Circulation, Volume 145, Issue 9, Page e761-e761, March 1, 2022. (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 145, Issue 9, Page 688-692, March 1, 2022. (Circulation)
• 08:00
  Taming Hypertension to Prevent Aortic Dissection: Universal Recognition of a “New Normal” Blood Pressure? - Christoph A. Nienaber Xun Yuan Cardiology and Aortic Centre, Royal Brompton and Harefield Hospitals, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK (C.A.N., X.Y.). National Heart and Lung Institute, Faculty of Medicine, Imperial College London, UK. (C.A.N., X.Y.). Circulation
  Circulation, Volume 145, Issue 9, Page 645-647, March 1, 2022. (Circulation)

25 February

Circulation http://ahajournals.org/

• 11:00
  Nationwide Analysis of Persistent Type II Endoleak and Late Outcomes of Endovascular Abdominal Aortic Aneurysm Repair in Japan: A Propensity-Matched Analysis - Yoshimasa Seike Hitoshi Matsuda Hideyuki Shimizu Shin Ishimaru Katsuyuki Hoshina Nobuaki Michihata Hideo Yasunaga Kimihiro Komori Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan (Y.S., H.M.). Department of Cardiovascular Surgery, Keio University, Tokyo, Japan (H.S.). Department of Cardiovascular Surgery, Toda Chuo General Hospital, Saitama, Japan (S.I.). Department of Vascular Surgery (K.H.), University of Tokyo, Japan. Department of Clinical Epidemiology and Health Economics, School of Public Health (N.M., H.Y.), University of Tokyo, (...) Circulation
  Circulation, Volume 145, Issue 14, Page 1056-1066, April 5, 2022. Background:We reviewed the results of endovascular aneurysm repair in patients from the Japanese Committee for Stentgraft Management registry to determine the significance of persistent type II endoleak (p-T2EL) and the risk of (...) (Circulation)
• 10:15
  Cytokine Hemoadsorption During Cardiac Surgery Versus Standard Surgical Care for Infective Endocarditis (REMOVE): Results From a Multicenter Randomized Controlled Trial - Mahmoud Diab Thomas Lehmann Wolfgang Bothe Payam Akhyari Stephanie Platzer Daniel Wendt Antje-Christin Deppe Justus Strauch Stefan Hagel Albrecht Günther Gloria Faerber Christoph Sponholz Marcus Franz André Scherag Ilia Velichkov Miriam Silaschi Jens Fassl Britt Hofmann Sven Lehmann Rene Schramm Georg Fritz Gabor Szabo Thorsten Wahlers Klaus Matschke Artur Lichtenberg Mathias W. Pletz Jan F. Gummert Friedhelm Beyersdorf Christian Hagl Michael A. Borger Michael Bauer Frank M. Brunkhorst Torsten Doenst Department of Cardiothoracic Surgery (M.D., G. Faerber, I.V., T.D.), Jena University (...) Circulation
  Circulation, Volume 145, Issue 13, Page 959-968, March 29, 2022. Background:Cardiac surgery often represents the only treatment option in patients with infective endocarditis (IE). However, IE surgery may lead to a sudden release of inflammatory mediators, which is associated with postoperative (...) (Circulation)

23 February

Circulation http://ahajournals.org/

• 11:00
  Insulin Prevents Hypercholesterolemia by Suppressing 12?-Hydroxylated Bile Acids - Ivana Semova Amy E. Levenson Joanna Krawczyk Kevin Bullock Mary E. Gearing Alisha V. Ling Kathryn A. Williams Ji Miao Stuart S. Adamson Dong-Ju Shin Satyapal Chahar Mark J. Graham Rosanne M. Crooke Lee R. Hagey David Vicent Sarah D. de Ferranti Srividya Kidambi Clary B. Clish Sudha B. Biddinger Division of Endocrinology (I.S., A.E.L., J.K., M.E.G., A.V.L., J.M., S.S.A., D.-J.S., S.C., S.B.B.), Boston Children’s Hospital, Harvard Medical School, MA. Department of Cardiology (S.D.d.F.), Boston Children’s Hospital, Harvard Medical School, MA. Broad Institute of MIT and Harvard, Cambridge, MA (...) Circulation
  Circulation, Volume 145, Issue 13, Page 969-982, March 29, 2022. Background:The risk of cardiovascular disease in type 1 diabetes remains extremely high, despite marked advances in blood glucose control and even the widespread use of cholesterol synthesis inhibitors. Thus, a deeper (...) (Circulation)

22 February

Circulation http://ahajournals.org/

• 11:00
  Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis - Jin-Kai Wang Yang Li Xiao-Lu Zhao Yuan-Bin Liu Jing Tan Yu-Ying Xing Dilare Adi Yong-Tao Wang Zhen-Yan Fu Yi-Tong Ma Song-Mei Liu Yong Liu Yan Wang Xiong-Jie Shi Xiao-Yi Lu Bao-Liang Song Jie Luo Institute for Advanced Studies, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, China (J.-K.W., X.-L.Z., Y.-B.L., J.T., Y.-Y.X., Y. Liu, Y.W., X.-J.S., X.-Y.L., B.-L.S., J.L.). Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China (Y. Li, D.A., (...) Circulation
  Circulation, Volume 145, Issue 9, Page 675-687, March 1, 2022. Background:High blood cholesterol accelerates the progression of atherosclerosis, which is an asymptomatic process lasting for decades. Rupture of atherosclerotic plaques induces thrombosis, which results in myocardial infarction or (...) (Circulation)

21 February

Circulation http://ahajournals.org/

• 11:00
  e-Cigarette Aerosol Reduces Left Ventricular Function in Adolescent Mice - Evan W. Neczypor Ty A. Saldaña Matthew J. Mears David M. Aslaner Yael-Natalie H. Escobar Matthew W. Gorr Loren E. Wold Dorothy M. Davis Heart and Lung Research Institute and Department of Physiology and Cell Biology, College of Medicine and Wexner Medical Center, and College of Nursing, Ohio State University, Columbus. Circulation
  Circulation, Volume 145, Issue 11, Page 868-870, March 15, 2022. (Circulation)
• 08:00
  A Pacemaker Red Herring and a Hypertrophic Cardiomyopathy Copycat - Inbar Raber Nicholas O. Palmeri Usman A. Tahir Peter J. Zimetbaum Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Circulation
  Circulation, Volume 145, Issue 8, Page 622-625, February 22, 2022. (Circulation)
• 08:00
  Universal Health Care System and Cardiovascular Disease Burden in Italy - Ciro Indolfi Giovanni Esposito Division of Cardiology, Research Center for Cardiovascular Diseases, University Magna Graecia, Viale Europa, Catanzaro, Italy (C.I.). Mediterranea Cardiocentro, Naples, Italy (C.I.). Division of Cardiology Department of Advanced Biomedical Sciences, University of Naples Federico II, Italy (G.E.). Circulation
  Circulation, Volume 145, Issue 8, Page 559-561, February 22, 2022. (Circulation)
• 08:00
  A Mechanical Bridge to Recovery as a Bridge to Discovery: Learning From Few and Applying to Many - Iosif Taleb Eleni Tseliou James C. Fang Stavros G. Drakos Division of Cardiovascular Medicine (I.T., E.T., J.C.F., S.G.D.), University of Utah Health, Salt Lake City. Nora Eccles Harrison Cardiovascular Research and Training Institute (I.T., E.T., S.G.D.), University of Utah Health, Salt Lake City. Circulation
  Circulation, Volume 145, Issue 8, Page 562-564, February 22, 2022. (Circulation)
• 08:00
  Letter by Wang et al Regarding Article, “HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression” - Fudi Wang Junxia Min Chaodong Ge The Fourth Affiliated Hospital, The First Affiliated Hospital, Institute of Translational Medicine, Cancer Center, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China (F.W.,J.M.,C.G.). The First Affiliated Hospital, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China (F.W.). Circulation
  Circulation, Volume 145, Issue 8, Page e149-e150, February 22, 2022. (Circulation)
• 08:00
  Response by Zhang and Ji to Letter Regarding Article, “HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression” - Yan Zhang Yong Ji Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Key Laboratory of Cardiovascular and Cerebrovascular Medicine (Y.Z., Y.J.), Nanjing Medical University, China. State Key Laboratory of Reproductive Medicine (Y.J.), Nanjing Medical University, China. The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School (Y.J.), Nanjing Medical University, (...) Circulation
  Circulation, Volume 145, Issue 8, Page e151-e152, February 22, 2022. (Circulation)
• 08:00
  Long-Term Efficacy of Colchicine in Patients With Chronic Coronary Disease: Insights From LoDoCo2 - Tjerk S.J. Opstal Amber van Broekhoven Aernoud T.L. Fiolet Arend Mosterd John W. Eikelboom Stefan M. Nidorf Peter L. Thompson Charley A. Budgeon Louis Bartels Ron de Nooijer Willem A. Bax Jan G.P. Tijssen Saloua El Messaoudi Jan H. Cornel Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (T.S.J.O., A.v.B., S.E.M., J.H.C.). Department of Cardiology, Northwest Clinics, Alkmaar, The Netherlands (T.S.J.O., J.H.C.). Department of Cardiology, University Medical Center Utrecht, The Netherlands (A.T.L.F.). Dutch Network for Cardiovascular Research (Werkgroep (...) Circulation
  Circulation, Volume 145, Issue 8, Page 626-628, February 22, 2022. (Circulation)
• 08:00
  Correction to: Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex Circulation
  Circulation, Volume 145, Issue 8, Page e640-e640, February 22, 2022. (Circulation)
• 08:00
  Correction to: Kidney Function After Initiation and Discontinuation of Empagliflozin in Patients With Heart Failure With and Without Type 2 Diabetes: Insights From the EMPERIAL Trials Circulation
  Circulation, Volume 145, Issue 8, Page e641-e641, February 22, 2022. (Circulation)
• 08:00
  From the Literature - Tracy Hampton Circulation
  Circulation, Volume 145, Issue 8, Page 620-621, February 22, 2022. (Circulation)
• 08:00
  New Insights Into the Molecular Underpinnings of LVNC - John D. Mably Joseph C. Wu Da-Zhi Wang University of South Florida Health Heart Institute, Center for Regenerative Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL (J.D.M., D.-Z.W.). Stanford Cardiovascular Institute, Stanford University, Stanford, CA (J.C.W.). Circulation
  Circulation, Volume 145, Issue 8, Page 603-605, February 22, 2022. (Circulation)

17 February

Circulation http://ahajournals.org/

• 08:06
  SPARC, a Novel Regulator of Vascular Cell Function in Pulmonary Hypertension - Christine Veith Ipek Vartürk-Özcan Magdalena Wujak Stefan Hadzic Cheng-Yu Wu Fenja Knoepp Simone Kraut Aleksandar Petrovic Marija Gredic Oleg Pak Monika Brosien Marie Heimbrodt Jochen Wilhelm Friederike C. Weisel Kathrin Malkmus Katharina Schäfer Henning Gall Khodr Tello Djuro Kosanovic Akylbek Sydykov Akpay Sarybaev Andreas Günther Ralf P. Brandes Werner Seeger Friedrich Grimminger Hossein A. Ghofrani Ralph T. Schermuly Grazyna Kwapiszewska Natascha Sommer Norbert Weissmann Excellence Cluster Cardio-Pulmonary Institute, University of Giessen and Marburg Lung Center, Member of the German (...) Circulation
  Circulation, Volume 145, Issue 12, Page 916-933, March 22, 2022. Background:Pulmonary hypertension (PH) is a life-threatening disease, characterized by excessive pulmonary vascular remodeling, leading to elevated pulmonary arterial pressure and right heart hypertrophy. PH can be caused by (...) (Circulation)

15 February

Circulation http://ahajournals.org/

• 08:05
  Elevated MCU Expression by CaMKII?B Limits Pathological Cardiac Remodeling - Pei Wang Shangcheng Xu Jiqian Xu Yanguo Xin Yan Lu Huiliang Zhang Bo Zhou Haodong Xu Shey-Shing Sheu Rong Tian Wang Wang Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine (P.W., S.X., J.X., Y.X., H.Z., B.Z., R.T., W.W.), University of Washington, Seattle. Department of Laboratory Medicine and Pathology (Y.L., H.Z., H.X., W.W.), University of Washington, Seattle. Center for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA (...) Circulation
  Circulation, Volume 145, Issue 14, Page 1067-1083, April 5, 2022. Background:Calcium (Ca2+) is a key regulator of energy metabolism. Impaired Ca2+homeostasis damages mitochondria, causing cardiomyocyte death, pathological hypertrophy, and heart failure. This study investigates the regulation (...) (Circulation)
• 11:00
  Optimizing Outcomes After Out-of-Hospital Cardiac Arrest With Innovative Approaches to Public-Access Defibrillation: A Scientific Statement From the International Liaison Committee on Resuscitation - Steven C. Brooks Gareth R. Clegg Janet Bray Charles D. Deakin Gavin D. Perkins Mattias Ringh Christopher M. Smith Mark S. Link Raina M. Merchant Jaime Pezo-Morales Michael Parr Laurie J. Morrison Tzong-Luen Wang Rudolph W. Koster Marcus E.H. Ong Circulation
  Circulation, Volume 145, Issue 13, Page e776-e801, March 29, 2022. Out-of-hospital cardiac arrest is a global public health issue experienced by ?3.8 million people annually. Only 8% to 12% survive to hospital discharge. Early defibrillation of shockable rhythms is associated with improved (...) (Circulation)

14 February

Circulation http://ahajournals.org/

• 08:00
  Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha–Mediated CD8+ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease - Livia S.A. Passos Prabhash K. Jha Dakota Becker-Greene Mark C. Blaser Dayanna Romero Adrien Lupieri Galina K. Sukhova Peter Libby Sasha A. Singh Walderez O. Dutra Masanori Aikawa Robert A. Levine Maria C.P. Nunes Elena Aikawa Center for Excellence in Vascular Biology (L.S.A.P., P.K.J., D.B.-G., D.R., A.L., G.K.S., P.L., M.A., E.A.), Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. Center for Interdisciplinary Cardiovascular Sciences (M.C.B., S.A.S., M.A., E.A.), Division of Cardiovascular Medicine, Department of (...) Circulation
  Circulation, Volume 145, Issue 7, Page 531-548, February 15, 2022. Background:Rheumatic heart valve disease (RHVD) is a leading cause of cardiovascular death in low- and middle-income countries and affects predominantly women. The underlying mechanisms of chronic valvular damage remain (...) (Circulation)
• 08:00
  Sex Differences in Use and Response to Cardiac Rhythm Management Devices - Anne B. Curtis Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, NY. Circulation
  Circulation, Volume 145, Issue 7, Page 505-506, February 15, 2022. (Circulation)
• 08:00
  Statin Use in Pregnancy: Is It Time For a Paradigm Shift? - Rina Mauricio Amit Khera Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas. Circulation
  Circulation, Volume 145, Issue 7, Page 496-498, February 15, 2022. (Circulation)
• 08:00
  How to Incorporate Sex and Gender Into the Design of Cardiovascular Clinical Trials - Carolyn S.P. Lam National Heart Centre Singapore and Duke–National University of Singapore; and University Medical Centre Groningen, The Netherlands. Circulation
  Circulation, Volume 145, Issue 7, Page 499-501, February 15, 2022. (Circulation)
• 08:00
  Call for Action to Address Increasing Maternal Cardiovascular Mortality in the United States: Strategies for Improving Maternal Cardiovascular Care - Kathryn J. Lindley Cardiovascular Division, Washington University School of Medicine, St. Louis, MO. Circulation
  Circulation, Volume 145, Issue 7, Page 502-504, February 15, 2022. (Circulation)
• 08:00
  Sex Differences in Cardio-Oncology: Considerations for the Practicing Clinician and Researcher - Tochukwu M. Okwuosa Vlad G. Zaha Department of Internal Medicine, Division of Cardiovascular Medicine, Rush University Medical Center, Chicago, IL (T.M.). Department of Internal Medicine, Cardiology Division, Cardio-Oncology Program, Harold C. Simmons Comprehensive Cancer Center, and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas (V.G.Z). Parkland Health and Hospital System, Dallas, TX (V.G.Z). Circulation
  Circulation, Volume 145, Issue 7, Page 510-512, February 15, 2022. (Circulation)
• 08:00
  Shining a Light on the Superwoman Schema and Maternal Health - Rachel M. Bond Annette Ansong Michelle A. Albert Dignity Health, Arizona, Chandler (R.M.B.). Division of Cardiology, Department of Internal Medicine, Creighton University School of Medicine, Omaha, NE (R.M.B.). Division of Cardiology, Children’s National Hospital, Washington, DC (A.A.). Center for the Study of Adversity and Cardiovascular Disease (NURTURE Center), Division of Cardiology, Department of Medicine, University of California, San Francisco School of Medicine (...) Circulation
  Circulation, Volume 145, Issue 7, Page 507-509, February 15, 2022. (Circulation)
• 08:00
  Microvascular Outcomes in Women With a History of Hypertension in Pregnancy - Michael C. Honigberg Seyedeh M. Zekavat Vineet K. Raghu Pradeep Natarajan Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston (M.C.H., P.N.). Cardiovascular Research Center (M.C.H., V.K.R., P.N.), Massachusetts General Hospital, Harvard Medical School, Boston. Cardiovascular Imaging Research Center (V.K.R.), Massachusetts General Hospital, Harvard Medical School, Boston. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA (M.C.H., S.M.Z., V.K.R., P.N.). Computational Biology and Bioinformatics Program, Yale (...) Circulation
  Circulation, Volume 145, Issue 7, Page 552-554, February 15, 2022. (Circulation)
• 08:00
  Spontaneous Coronary Artery Dissection: Insights From Cardiac Magnetic Resonance and Extracoronary Arterial Screening - Emmanuel Androulakis Alessia Azzu Panagiotis Papagkikas Alexios Antonopoulos Abtehale Al-Hussaini Dudley Pennell Raad Mohiaddin Royal Brompton Hospital and Harefield Hospitals, Guy’s and St. Thomas’ NHS Foundation Trust, London, UK (E.A., A.A., P.P., A.A., D.P., R.M.). Department of Cardiology, Chelsea and Westminster Hospital, London, UK (A.A.-H.). National Heart and Lung Institute, Imperial College, London, UK (D.P., R.M.). Circulation
  Circulation, Volume 145, Issue 7, Page 555-557, February 15, 2022. (Circulation)
• 08:00
  Geographic Differences in Prepregnancy Cardiometabolic Health in the United States, 2016 Through 2019 - Natalie A. Cameron Priya M. Freaney Michael C. Wang Amanda M. Perak Brigid M. Dolan Matthew J. O’Brien S. Darius Tandon Matthew M. Davis William A. Grobman Norrina B. Allen Philip Greenland Donald M. Lloyd-Jones Sadiya S. Khan Department of Medicine, Division of Internal Medicine and Geriatrics (N.A.C., M.C.W., B.M.D., M.J.O.), Northwestern University Feinberg School of Medicine, Chicago, IL. Division of Cardiology (P.M.F., P.G., D.M.L.-J., S.S.K.), Northwestern University Feinberg School of Medicine, Chicago, IL. Department of Preventive Medicine (A.M.P., N.B.A., P.G., D.M.L.-J., S.S.K.), (...) Circulation
  Circulation, Volume 145, Issue 7, Page 549-551, February 15, 2022. (Circulation)
• 08:00
  Sixth Annual Go Red for Women Issue - Biykem Bozkurt Joseph A. Hill Sana M. Al-Khatib Winters Center for Heart Failure Research, Cardiovascular Research Institute, Baylor College of Medicine, Michael E. DeBakey VA Medical Center, Houston, TX (B.B.). Departments of Internal Medicine, Cardiology Division, and Molecular Biology, University of Texas Southwestern Medical Center, Dallas (J.A.H.). Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (...) Circulation
  Circulation, Volume 145, Issue 7, Page 489-490, February 15, 2022. (Circulation)
• 08:00
  On the Shoulders of Witnesses: A Conversation With Biykem Bozkurt, MD, PhD - Biykem Bozkurt Maryjane Farr Circulation
  Circulation, Volume 145, Issue 7, Page 491-495, February 15, 2022. (Circulation)

10 February

Circulation http://ahajournals.org/

• 07:15
  Fetal Brain Volume Predicts Neurodevelopment in Congenital Heart Disease - Anjali Sadhwani David Wypij Valerie Rofeberg Ali Gholipour Maggie Mittleman Julia Rohde Clemente Velasco-Annis Johanna Calderon Kevin G. Friedman Wayne Tworetzky P. Ellen Grant Janet S. Soul Simon K. Warfield Jane W. Newburger Cynthia M. Ortinau Caitlin K. Rollins Department of Psychiatry and Behavioral Sciences (A.S., J.C.), Boston Children’s Hospital, MA. Department of Cardiology (D.W., V.R., K.G.F., W.T., J.W.N.), Boston Children’s Hospital, MA. Department of Radiology (A.G., C.V.-A., P.E.G., S.K.W.), Boston Children’s Hospital, MA. Department of Neurology (M.M., J.R., J.S.S., C.K.R.), (...) Circulation
  Circulation, Volume 145, Issue 15, Page 1108-1119, April 12, 2022. Background:Neurodevelopmental impairment is common in children with congenital heart disease (CHD), but postnatal variables explain only 30% of the variance in outcomes. To explore whether the antecedents for neurodevelopmental (...) (Circulation)
• 08:55
  Second Heart Field–Derived Cells Contribute to Angiotensin II–Mediated Ascending Aortopathies - Hisashi Sawada Yuriko Katsumata Hideyuki Higashi Chen Zhang Yanming Li Stephanie Morgan Lang H. Lee Sasha A. Singh Jeff Z. Chen Michael K. Franklin Jessica J. Moorleghen Deborah A. Howatt Debra L. Rateri Ying H. Shen Scott A. LeMaire Masanori Aikawa Mark W. Majesky Hong S. Lu Alan Daugherty Saha Cardiovascular Research Center (H.S., J.Z.C., M.K.F., J.J.M., D.A.H., D.L.R., H.S.L., A.D.), University of Kentucky, Lexington. Saha Aortic Center (H.S., H.S.L., A.D.), University of Kentucky, Lexington. Department of Physiology (H.S., J.Z.C., H.S.L., A.D.), University of Kentucky, Lexington. (...) Circulation
  Circulation, Volume 145, Issue 13, Page 987-1001, March 29, 2022. Background:The ascending aorta is a common location for aneurysm and dissection. This aortic region is populated by a mosaic of medial and adventitial cells that are embryonically derived from either the second heart field (SHF) (...) (Circulation)

9 February

Circulation http://ahajournals.org/

• 11:00
  MRI-Detected Brain Lesions and Cognitive Function in Patients With Atrial Fibrillation Undergoing Left Atrial Catheter Ablation in the Randomized AXAFA-AFNET 5 Trial - Karl Georg Haeusler Felizitas A. Eichner Peter U. Heuschmann Jochen B. Fiebach Tobias Engelhorn Benjamin Blank David Callans Arif Elvan Massimo Grimaldi Jim Hansen Gerhard Hindricks Hussein R. Al-Khalidi Lluis Mont Jens Cosedis Nielsen Jonathan P. Piccini Ulrich Schotten Sakis Themistoclakis Johan Vijgen Luigi Di Biase Paulus Kirchhof Atrial Fibrillation Network (AFNET), Münster, Germany (K.G.H., B.B., U.S., P.K.). Department of Neurology, Universitätsklinikum Würzburg, Germany (K.G.H.). Institute of Clinical Epidemiology and Biometry, University Würzburg, Germany (F.A.E., P.U.H.). Clinical (...) Circulation
  Circulation, Volume 145, Issue 12, Page 906-915, March 22, 2022. Background:We aimed to assess the prevalence of ischemic brain lesions detected by magnetic resonance imaging and their association with cognitive function 3 months after first-time ablation using continuous oral anticoagulation (...) (Circulation)

7 February

Circulation http://ahajournals.org/

• 08:00
  Why Are We Still Prescribing Angiotensin-Converting Enzyme Inhibitors? - Franz H. Messerli Chirag Bavishi Sripal Bangalore Swiss Cardiovascular Center, University of Bern, Switzerland (F.H.M.). Department of Cardiology, Lifespan Cardiovascular Institute, Warren Alpert Medical School at Brown University, Providence, RI (C.B.). NYU Langone Hospitals, New York University School of Medicine (S.B.). Circulation
  Circulation, Volume 145, Issue 6, Page 413-415, February 8, 2022. (Circulation)
• 08:00
  Regular Acetaminophen Use and Blood Pressure in People With Hypertension: The PATH-BP Trial - Iain M. MacIntyre Emma J. Turtle Tariq E. Farrah Catriona Graham James W. Dear David J. Webb Department of Renal Medicine, Royal Infirmary of Edinburgh, National Health Service Lothian, UK (I.M.M., T.E.F.). University/British Heart Foundation Center of Research Excellence, Center for Cardiovascular Science, Queen’s Medical Research Institute (I.M.M., E.J.T., T.E.F., J.W.D., D.J.W.), University of Edinburgh, UK. Edinburgh Clinical Research Facility (C.G.), University of Edinburgh, UK., for the PATH-BP (Paracetamol in Hypertension–Blood Pressure) Investigators* Morag McCallum Vanessa Melville (...) Circulation
  Circulation, Volume 145, Issue 6, Page 416-423, February 8, 2022. Background:Acetaminophen is widely used as first-line therapy for chronic pain because of its perceived safety and the assumption that, unlike nonsteroidal anti-inflammatory drugs, it has little or no effect on blood pressure (...) (Circulation)
• 08:00
  One-Year Major Cardiovascular Events After Restrictive Versus Liberal Blood Transfusion Strategy in Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Trial - Jose R. Gonzalez-Juanatey Gilles Lemesle Etienne Puymirat Gregory Ducrocq Marine Cachanado Joan Albert Arnaiz Manuel Martínez-Sellés Johanne Silvain Albert Ariza-Solé Emile Ferrari Gonzalo Calvo Nicolas Danchin Cristina Avendano-Solá Alexandra Rousseau Eric Vicaut Teba Gonzalez-Ferrero Philippe Gabriel Steg Tabassome Simon Cardiology Department, University Hospital, Health Research Institute of Santiago de Compostela, Centro de Investigación en Red de Enfermedades Cardiovasculares, University of Santiago de Compostela, Spain (J.R.G.-J., T.G.-F.). Institut Cœur Poumon, Centre Hospitalier (...) Circulation
  Circulation, Volume 145, Issue 6, Page 486-488, February 8, 2022. (Circulation)
• 08:00
  Rev-erb–Mediated Regulation of Cardiac Metabolism in the Obesity Paradox - Inna Rabinovich-Nikitin Lorrie A. Kirshenbaum Department of Physiology and Pathophysiology, The Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada (I.R-N., L.A.K.). Department of Pharmacology and Therapeutics, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada (L.A.K.). Circulation
  Circulation, Volume 145, Issue 6, Page 465-468, February 8, 2022. (Circulation)
• 08:00
  Acetaminophen-Induced Hypertension: Where Have All the “Safe” Analgesics Gone? - Steven M. Smith Rhonda M. Cooper-DeHoff Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL. Circulation
  Circulation, Volume 145, Issue 6, Page 424-426, February 8, 2022. (Circulation)

4 February

Circulation http://ahajournals.org/

• 11:00
  lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth - Haobo Li Lena E. Trager Xiaojun Liu Margaret H. Hastings Chunyang Xiao Justin Guerra Samantha To Guoping Li Ashish Yeri Rodosthenis Rodosthenous Michael G. Silverman Saumya Das Amrut V. Ambardekar Michael R. Bristow Juan Manuel González-Rosa Anthony Rosenzweig Corrigan-Minehan Heart Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston (H.L., L.E.T., X.L., M.H.H., C.X., J.G., S.T., G.L., A.Y., R.R., M.G.S., S.D., J.M.G.-R., A.R.). Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora (A.V.A., (...) Circulation
  Circulation, Volume 145, Issue 16, Page 1218-1233, April 19, 2022. Background:The heart grows in response to pathological and physiological stimuli. The former often precedes cardiomyocyte loss and heart failure; the latter paradoxically protects the heart and enhances cardiomyogenesis. The (...) (Circulation)

3 February

Circulation http://ahajournals.org/

• 07:09
  CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells - Guoshuai Feng Geetika Bajpai Pan Ma Andrew Koenig Andrea Bredemeyer Inessa Lokshina Lulu Lai Irmgard Förster Florian Leuschner Daniel Kreisel Kory J. Lavine Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, MO (G.F., G.B., P.M., A.K., A.B., I.L., L.L., K.J.L.). LIMES Institute, University of Bonn, Germany (I.F.). Department of Internal Medicine III, University Hospital Heidelberg, University of Heidelberg, Germany (F.L.). Departments of Surgery (D.K.), Washington University, St Louis, MO. Pathology and Immunology (D.K., K.J.L.), Washington (...) Circulation
  Circulation, Volume 145, Issue 10, Page 765-782, March 8, 2022. Background:Recent studies have established that CCR2 (C-C chemokine receptor type 2) marks proinflammatory subsets of monocytes, macrophages, and dendritic cells that contribute to adverse left ventricle (LV) remodeling and heart (...) (Circulation)
• 07:21
  Patient-Specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunction - Antoinette F. van Ouwerkerk Fernanda M. Bosada Karel van Duijvenboden Arjan C. Houweling Koen T. Scholman Vincent Wakker Cornelis P. Allaart Jae-Sun Uhm Inge B. Mathijssen Ton Baartscheer Alex V. Postma Phil Barnett Arie O. Verkerk Bastiaan J. Boukens Vincent M. Christoffels Department of Medical Biology (A.F.vO., F.M.B., K.vD., K.T.S., V.W., J-S.U., A.V.P., P.B., A.O.V., B.J.B., V.M.C.), University of Amsterdam, The Netherlands. Experimental Cardiology (T.B., A.O.V.), University of Amsterdam, The Netherlands. Department of Cardiology, Vrije Universiteit Amsterdam (C.P.A.), Amsterdam (...) Circulation
  Circulation, Volume 145, Issue 8, Page 606-619, February 22, 2022. Background:The pathogenic missense variant p.G125R in TBX5 (T-box transcription factor 5) causes Holt–Oram syndrome (also known as hand–heart syndrome) and early onset of atrial fibrillation. Revealing how an altered key (...) (Circulation)

31 January

Circulation http://ahajournals.org/

• 11:00
  American Heart Association’s Life’s Simple 7: Lifestyle Recommendations, Polygenic Risk, and Lifetime Risk of Coronary Heart Disease - Natalie R. Hasbani Symen Ligthart Michael R. Brown Adam S. Heath Allison Bebo Kellan E. Ashley Eric Boerwinkle Alanna C. Morrison Aaron R. Folsom David Aguilar Paul S. de Vries Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston (N.R.H., M.R.B., A.S.H., A.B., E.B., A.C.M., P.S.d.V). Department of Epidemiology and Adult Intensive Care, Erasmus University Medical Center, Rotterdam, the Netherlands (S.L.). Departments of Interventional Cardiovascular Disease and (...) Circulation
  Circulation, Volume 145, Issue 11, Page 808-818, March 15, 2022. Background:Understanding the effect of lifestyle and genetic risk on the lifetime risk of coronary heart disease (CHD) is important to improving public health initiatives. Our objective was to quantify remaining lifetime risk and (...) (Circulation)
• 12:51
  Legumain Is an Endogenous Modulator of Integrin ?v?3 Triggering Vascular Degeneration, Dissection, and Rupture - Lihong Pan Peiyuan Bai Xinyu Weng Jin Liu Yingjie Chen Siqin Chen Xiurui Ma Kai Hu Aijun Sun Junbo Ge Institutes of Biomedical Sciences, Fudan University, Shanghai, China (L.P., S.C., A.S., J.G.). Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, China (P.B., X.W., J.L., X.M., K.H., A.S., J.G.). Key Laboratory of Viral Heart Diseases, National Health Commission, Shanghai, China (L.P., P.B., X.W., J.L., S.C., X.M., A.S., J.G.). Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China (L.P., (...) Circulation
  Circulation, Volume 145, Issue 9, Page 659-674, March 1, 2022. Background:The development of thoracic aortic dissection (TAD) is closely related to extracellular matrix degradation and vascular smooth muscle cell (VSMC) transformation from contractile to synthetic type. LGMN (legumain) degrades (...) (Circulation)
• 08:00
  Salt-Induced Hepatic Inflammatory Memory Contributes to Cardiovascular Damage Through Epigenetic Modulation of SIRT3 - Peng Gao Mei You Li Li Qin Zhang Xia Fang Xiao Wei Qing Zhou Hexuan Zhang Miao Wang Zongshi Lu Lijuan Wang Fang Sun Daoyan Liu Hongting Zheng Zhencheng Yan Gangyi Yang Zhiming Zhu Department of Hypertension and Endocrinology, Center for Hypertension and Metabolic Diseases, Daping Hospital, Chongqing Institute of Hypertension (P.G., M.Y., L.L., X.W., Q. Zhou, H.Z., Z.L., L.W., F.S., D.L., Z.Y., Z.Z.), Army Medical University, Chongqing China. Department of Endocrinology, Translational Research Key Laboratory for Diabetes, Xinqiao Hospital (H.Z.), Army Medical University, Chongqing China. (...) Circulation
  Circulation, Volume 145, Issue 5, Page 375-391, February 1, 2022. Background:High salt intake is the leading dietary risk factor for cardiovascular diseases. Although clinical evidence suggests that high salt intake is associated with nonalcoholic fatty liver disease, which is an independent (...) (Circulation)
• 08:00
  Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration - Léna Rivard Leif Friberg David Conen Jeffrey S. Healey Trygve Berge Giuseppe Boriani Axel Brandes Hugh Calkins A. John Camm Lin Yee Chen Josep Lluis Clua Espuny Ronan Collins Stuart Connolly Nikolaos Dagres Mitchell S.V. Elkind Johan Engdahl Thalia S. Field Bernard J. Gersh Taya V. Glotzer Graeme J. Hankey Joseph A. Harbison Karl Georg Haeusler Mellanie T. Hills Linda S.B. Johnson Boyoung Joung Paul Khairy Paulus Kirchhof Derk Krieger Gregory Y.H. Lip Maja-Lisa Løchen Malini Madhavan Georges H. Mairesse Joan Montaner George Ntaios Terence J. Quinn Michiel Rienstra Mårten Rosenqvist Roopinder (...) Circulation
  Circulation, Volume 145, Issue 5, Page 392-409, February 1, 2022. Growing evidence suggests a consistent association between atrial fibrillation (AF) and cognitive impairment and dementia that is independent of clinical stroke. This report from the AF-SCREEN International Collaboration (...) (Circulation)
• 08:00
  Thirty Years of No-Touch Saphenous Vein Harvesting: A Timely Jubilee Gift - Michael R. Dashwood Bruno Botelho Pinheiro Domingos S.R. Souza Surgical and Interventional Sciences, Royal Free Hospital Campus, University College London Medical School, United Kingdom (M.R.D.). Department of Cardiovascular Surgery, Hospital do Coração Anis Rassi, Goiânia, Goiás, Brazil (B.B.P.). Department of Cardiothoracic and Vascular Surgery, Faculty of Medicine and Health, Örebro University, Sweden (D.S.R.S.). Circulation
  Circulation, Volume 145, Issue 5, Page 319-320, February 1, 2022. (Circulation)
• 08:00
  Letter by Enas and Varkey Regarding Article, “Quantifying and Understanding the Higher Risk of Atherosclerotic Cardiovascular Disease Among South Asian Individuals: Results From the UK Biobank Prospective Cohort Study” - Enas A. Enas Basil Varkey Coronary Artery Disease Among Asian Indians (CADI) Research Foundation, Lisle, IL. Circulation
  Circulation, Volume 145, Issue 5, Page e146-e146, February 1, 2022. (Circulation)
• 08:00
  Response by Patel and Khera to Letter Regarding Article, “Quantifying and Understanding the Higher Risk of Atherosclerotic Cardiovascular Disease Among South Asian Individuals: Results From the UK Biobank Prospective Cohort Study” - Aniruddh P. Patel Amit V. Khera Center for Genomic Medicine and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston. Cardiovascular Disease Initiative, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge. Harvard Medical School, Boston, MA. Circulation
  Circulation, Volume 145, Issue 5, Page e147-e148, February 1, 2022. (Circulation)
• 08:00
  Genetic Proliferation Tracing Reveals a Rapid Cell Cycle Withdrawal in Preadolescent Cardiomyocytes - Wenjuan Pu Mingjun Zhang Xiuxiu Liu Lingjuan He Jie Li Ximeng Han Kathy O. Lui Ben He Bin Zhou State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China (W.P., M.Z., X.L., L.H., J.L., X.H., B.Z.). School of Life Sciences, Westlake University, Hangzhou, China (L.H.). Department of Chemical Pathology; and Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, China (K.O.L.). (...) Circulation
  Circulation, Volume 145, Issue 5, Page 410-412, February 1, 2022. (Circulation)
• 08:00
  The Power of Patient Stories to Inspire Us to Prevent Cardiovascular Disease and Death: Personal Reflections on the AHA’s Scientific Sessions 2021 - Donald M. Lloyd-Jones Departments of Preventive Medicine, Medicine, and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL. Circulation
  Circulation, Volume 145, Issue 5, Page e143-e145, February 1, 2022. (Circulation)
• 08:00
  Linking Genetics and Proteomics: Gene-Protein Associations Built on Diversity - Heribert Schunkert Manuel Mayr Department of Cardiology, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany (H.S.). Deutsches Zentrum für Herz- und Kreislauferkrankungen, Partner Site Munich Heart Alliance, Munich, Germany (H.S.). King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences, United Kingdom (M.M.). Circulation
  Circulation, Volume 145, Issue 5, Page 371-374, February 1, 2022. (Circulation)
• 08:00
  Perplexing Results From the PRAETORIAN Trial: Revisiting the Debate About the Value of Antitachycardia Pacing - Sana M. Al-Khatib Mark S. Link Division of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (S.M.A.-K.). Cardiac Electrophysiology, University of Texas Southwestern Medical Center, Dallas (M.S.L.). Circulation
  Circulation, Volume 145, Issue 5, Page 330-332, February 1, 2022. (Circulation)

28 January

Circulation http://ahajournals.org/

• 08:24
  In Vitro Matured Human Pluripotent Stem Cell–Derived Cardiomyocytes Form Grafts With Enhanced Structure and Function in Injured Hearts - Wahiba Dhahri Tamilla Sadikov Valdman Dan Wilkinson Elizabeth Pereira Eylül Ceylan Naaz Andharia Beiping Qiang Hassan Masoudpour Fanny Wulkan Elya Quesnel Wenlei Jiang Shunsuke Funakoshi Amine Mazine M. Juliana Gomez-Garcia Neda Latifi Yidi Jiang Ella Huszti Craig A. Simmons Gordon Keller Michael A. Laflamme McEwen Stem Cell Institute (W.D., T.S.V., E.C., N.A., B.Q., H.M., F.W., E.Q., W.J., S.F., A.M., M.J.G.-G., G.K., M.A.L.), University Health Network, Toronto, ON, Canada. Biostatistics Research Unit (Y.J., E.H.), University Health Network, Toronto, ON, Canada. Peter Munk Cardiac Centre (...) Circulation
  Circulation, Volume 145, Issue 18, Page 1412-1426, May 3, 2022. Background:Human pluripotent stem cell (hPSC)–derived cardiomyocytes (hPSC-CMs) have tremendous promise for application in cardiac regeneration, but their translational potential is limited by an immature phenotype. We hypothesized (...) (Circulation)

26 January

Circulation http://ahajournals.org/

• 06:44
  Heart Xenotransplant: A Door That Is Finally Opening - Maryjane Farr Josef Stehlik Division of Cardiovascular Medicine, University of Texas Southwestern Medical Center, Dallas (M.F.). Division of Cardiovascular Medicine, University of Utah, Salt Lake City (J.S.). Circulation
  Circulation, Volume 145, Issue 12, Page 871-873, March 22, 2022. (Circulation)
• 11:00
  Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association - Connie W. Tsao Aaron W. Aday Zaid I. Almarzooq Alvaro Alonso Andrea Z. Beaton Marcio S. Bittencourt Amelia K. Boehme Alfred E. Buxton April P. Carson Yvonne Commodore-Mensah Mitchell S.V. Elkind Kelly R. Evenson Chete Eze-Nliam Jane F. Ferguson Giuliano Generoso Jennifer E. Ho Rizwan Kalani Sadiya S. Khan Brett M. Kissela Kristen L. Knutson Deborah A. Levine Tené T. Lewis Junxiu Liu Matthew Shane Loop Jun Ma Michael E. Mussolino Sankar D. Navaneethan Amanda Marma Perak Remy Poudel Mary Rezk-Hanna Gregory A. Roth Emily B. Schroeder Svati H. Shah Evan L. Thacker Lisa B. VanWagner Salim S. (...) Circulation
  Circulation, Volume 145, Issue 8, Page e153-e639, February 22, 2022. Background:The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including (...) (Circulation)

24 January

Circulation http://ahajournals.org/

• 08:00
  Letter by Costantine et al Regarding Article, “Pravastatin Versus Placebo in Pregnancies at High Risk of Term Preeclampsia” - Maged M. Costantine Kirsten Lawrence-Cleary Georges Saade Ronald J. Wapner Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus (M.M.C.). Department of Obstetrics and Gynecology, Yale University, New Haven, CT (K.L.-C.). Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston (G.S.). Department of Obstetrics and Gynecology, Columbia University, New York, NY (R.J.W.). Circulation
  Circulation, Volume 145, Issue 4, Page e115-e116, January 25, 2022. (Circulation)
• 08:00
  Multifaceted Spatial and Functional Zonation of Cardiac Cells in Adult Human Heart - Liang Chen Kui Hua Ningning Zhang Jingyu Wang Jian Meng Zhenliang Hu Haoxiang Gao Fanhong Li Yang Chen Jie Ren Liyang Liu Qiming Zhou Jin Gu Jiangping Song Xuegong Zhang Shengshou Hu State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.C., N.Z., J.M., Z.H., J.R., J.S., S.H.). MOE Key Laboratory of Bioinformatics, Bioinformatics Division, Beijing National Research Center for Information Science and Technology and Department of Automation (K.H., (...) Circulation
  Circulation, Volume 145, Issue 4, Page 315-318, January 25, 2022. (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 145, Issue 4, Page 309-314, January 25, 2022. (Circulation)
• 08:00
  A Patient-Level Meta-Analysis: The End of the Era of Direct Oral Anticoagulant Developmental Trials in Patients With Atrial Fibrillation? - Shinya Goto Shinichi Goto Department of Medicine (Cardiology), Tokai University School of Medicine, Isehara, Japan. Circulation
  Circulation, Volume 145, Issue 4, Page 256-258, January 25, 2022. (Circulation)
• 08:00
  Preventing Anthracycline-Induced Cardiotoxicity Using Functional Genomics and Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes - Valentina Lo Sardo Timothy J. Kamp Department of Cell and Regenerative Biology (V.LS., T.J.K.), University of Wisconsin-Madison. Stem Cell and Regenerative Medicine Center (V.LS., T.J.K.), University of Wisconsin-Madison. Department of Medicine (T.J.K.), University of Wisconsin-Madison. Circulation
  Circulation, Volume 145, Issue 4, Page 295-298, January 25, 2022. (Circulation)
• 08:00
  The Clinical Impact of Device Lead–Associated Tricuspid Regurgitation: Need for a Multidisciplinary Approach - Aviral Vij Clifford J. Kavinsky Division of Cardiology, Cook County Health, Chicago, IL (A.V.). Division of Cardiology, Rush Medical College, Chicago, IL (A.V., C.J.K.). Circulation
  Circulation, Volume 145, Issue 4, Page 239-241, January 25, 2022. (Circulation)

21 January

Circulation http://ahajournals.org/

• 07:21
  Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure - Riham R.E. Abouleisa Abou Bakr M. Salama Qinghui Ou Xian-Liang Tang Mitesh Solanki Yiru Guo Yibing Nong Lindsey McNally Pawel K. Lorkiewicz Kamal M. Kassem Brooke M. Ahern Krishna Choudhary Reuben Thomas Yu Huang Hamzah R. Juhardeen Aisha Siddique Zainab Ifthikar Sally K. Hammad Ayman S. Elbaz Kathryn N. Ivey Daniel J. Conklin Jonathan Satin Bradford G. Hill Deepak Srivastava Roberto Bolli Tamer M.A. Mohamed From the Institute of Molecular Cardiology (R.R.E.A., A.B.M.S., Q.O., X.-L.T., M.S., Y.G., Y.N., K.M.K., S.K.H., R.B., T.M.A.M.), University of Louisville, KY. Envirome Institute, (...) Circulation
  Circulation, Volume 145, Issue 17, Page 1339-1355, April 26, 2022. Background:The regenerative capacity of the heart after myocardial infarction is limited. Our previous study showed that ectopic introduction of 4 cell cycle factors (4F; CDK1 [cyclin-dependent kinase 1], CDK4 [cyclin-dependent (...) (Circulation)

20 January

Circulation http://ahajournals.org/

• 09:52
  Circulating Metabolome and White Matter Hyperintensities in Women and Men - Eeva Sliz Jean Shin Shahzad Ahmad Dylan M. Williams Stefan Frenzel Friederike Gauß Sarah E. Harris Ann-Kristin Henning Maria Valdes Hernandez Yi-Han Hu Beatriz Jiménez Muralidharan Sargurupremraj Carole Sudre Ruiqi Wang Katharina Wittfeld Qiong Yang Joanna M. Wardlaw Henry Völzke Meike W. Vernooij Jonathan M. Schott Marcus Richards Petroula Proitsi Matthias Nauck Matthew R. Lewis Lenore Launer Norbert Hosten Hans J. Grabe Mohsen Ghanbari Ian J. Deary Simon R. Cox Nishi Chaturvedi Josephine Barnes Jerome I. Rotter Stephanie Debette M. Arfan Ikram Myriam Fornage Tomas Paus Sudha Seshadri (...) Circulation
  Circulation, Volume 145, Issue 14, Page 1040-1052, April 5, 2022. Background:White matter hyperintensities (WMH), identified on T2-weighted magnetic resonance images of the human brain as areas of enhanced brightness, are a major risk factor of stroke, dementia, and death. There are no (...) (Circulation)
• 08:16
  Association Between Endovascular Therapy Time to Treatment and Outcomes in Patients With Basilar Artery Occlusion - Raed A. Joundi Jie-Lena Sun Ying Xian Brooke Alhanti Raul G. Nogueira Deepak L. Bhatt Gregg C. Fonarow Jeffrey Saver Lee H. Schwamm Eric E. Smith Department of Clinical Neurosciences (R.A.J., E.E.S.), University of Calgary, Canada. Hotchkiss Brain Institute (E.E.S.), University of Calgary, Canada. Division of Neurology, Hamilton Health Sciences, McMaster University & Population Health Research Institute, Canada (R.A.J.). Duke Clinical Research Center, Durham, NC (J.-L.S., B.A.). Marcus Stroke & Neuroscience Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, GA (...) Circulation
  Circulation, Volume 145, Issue 12, Page 896-905, March 22, 2022. Background:Basilar artery occlusion (BAO) is a devastating condition without definitive evidence to guide treatment. Whereas the association between faster treatment times with endovascular therapy (EVT) and better outcomes in (...) (Circulation)

19 January

Circulation http://ahajournals.org/

• 07:23
  Cost-Effectiveness of Coronary Artery Bypass Surgery Versus Medicine in Ischemic Cardiomyopathy: The STICH Randomized Clinical Trial - Derek S. Chew Patricia A. Cowper Hussein Al-Khalidi Kevin J. Anstrom Melanie R. Daniels Linda Davidson-Ray Yanhong Li Robert E. Michler Julio A. Panza Ileana L. Piña Jean L. Rouleau Eric J. Velazquez Daniel B. Mark Duke Clinical Research Institute (D.S.C., P.A.C., H.A., K.J.A., M.R.D., L.D.-R., Y.L., D.B.M.), Duke University, Durham, NC. Department of Biostatistics and Bioinformatics (H.A., K.J.A.), Duke University, Durham, NC. Department of Cardiac Sciences, Libin Cardiovascular Institute (D.S.C.), University of Calgary, Alberta, Canada. O’Brien Institute for Public Health (D.S.C.), (...) Circulation
  Circulation, Volume 145, Issue 11, Page 819-828, March 15, 2022. Background:The STICH Randomized Clinical Trial (Surgical Treatment for Ischemic Heart Failure) demonstrated that coronary artery bypass grafting (CABG) reduced all-cause mortality rates out to 10 years compared with medical (...) (Circulation)

18 January

Circulation http://ahajournals.org/

• 08:00
  E-Cigarettes and Cardiopulmonary Health: Review for Clinicians - Evan W. Neczypor Matthew J. Mears Arunava Ghosh M. Flori Sassano Richard J. Gumina Loren E. Wold Robert Tarran Colleges of Nursing and Medicine (E.W.N., M.J.M., L.E.W.), The Ohio State University, Columbus. Dorothy M. Davis Heart and Lung Research Institute, Department of Physiology and Cell Biology, College of Medicine (E.W.N., M.J.M., L.E.W.), The Ohio State University, Columbus. Department of Cell Biology and Physiology, The University of North Carolina, Chapel Hill (A.G., M.F.S., R.T.). Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University (...) Circulation
  Circulation, Volume 145, Issue 3, Page 219-232, January 18, 2022. Electronic cigarettes (e-cigarettes) are battery powered electronic nicotine delivery systems that use a propylene glycol/vegetable glycerin base to deliver vaporized nicotine and flavorings to the body. E-cigarettes became (...) (Circulation)
• 08:00
  From the Literature - Tracy Hampton Circulation
  Circulation, Volume 145, Issue 3, Page 233-234, January 18, 2022. (Circulation)

17 January

Circulation http://ahajournals.org/

• 11:00
  Myocardial Rev-erb–Mediated Diurnal Metabolic Rhythm and Obesity Paradox - Shiyang Song Chih-Liang Tien Hao Cui Paul Basil Ningxia Zhu Yingyun Gong Wenbo Li Hui Li Qiying Fan Jong Min Choi Weijia Luo Yanfeng Xue Rui Cao Wenjun Zhou Andrea R. Ortiz Brittany Stork Vatsala Mundra Nagireddy Putluri Brian York Maoping Chu Jiang Chang Sung Yun Jung Liang Xie Jiangping Song Lilei Zhang Zheng Sun Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism (S.S., P.B., N.Z., Y.G., W. Li, Y.X., R.C., W.Z., V.M., Z.S.), Baylor College of Medicine, Houston, TX. Department of Molecular and Human Genetics (C.-L.T., H.L., L.Z.), Baylor College of Medicine, (...) Circulation
  Circulation, Volume 145, Issue 6, Page 448-464, February 8, 2022. Background:The nuclear receptor Rev-erb?/?, a key component of the circadian clock, emerges as a drug target for heart diseases, but the function of cardiac Rev-erb has not been studied in vivo. Circadian disruption is implicated (...) (Circulation)

10 January

Circulation http://ahajournals.org/

• 11:00
  Comprehensive Management of Cardiovascular Risk Factors for Adults With Type 2 Diabetes: A Scientific Statement From the American Heart Association - Joshua J. Joseph Prakash Deedwania Tushar Acharya David Aguilar Deepak L. Bhatt Deborah A. Chyun Katherine E. Di Palo Sherita H. Golden Laurence S. Sperling Circulation
  Circulation, Volume 145, Issue 9, Page e722-e759, March 1, 2022. Cardiovascular disease remains the leading cause of death in patients with diabetes. Cardiovascular disease in diabetes is multifactorial, and control of the cardiovascular risk factors leads to substantial reductions in (...) (Circulation)
• 11:00
  Genes That Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts - Brian A. Aguado Cierra J. Walker Joseph C. Grim Megan E. Schroeder Dilara Batan Brandon J. Vogt Andrea Gonzalez Rodriguez Jessica A. Schwisow Karen S. Moulton Robert M. Weiss Donald D. Heistad Leslie A. Leinwand Kristi S. Anseth Department of Chemical and Biological Engineering (B.A.A., J.C.G., B.J.V., A.G.R., K.S.A.), University of Colorado, Boulder. BioFrontiers Institute (B.A.A., J.C.G., M.E.S., D.B., A.G.R., L.A.L., K.S.A.), University of Colorado, Boulder. Materials Science and Engineering Program (C.J.W., M.E.S., K.S.A.), University of Colorado, Boulder. Department of Biochemistry (...) Circulation
  Circulation, Volume 145, Issue 7, Page 513-530, February 15, 2022. Background:Aortic valve stenosis is a sexually dimorphic disease, with women often presenting with sustained fibrosis and men with more extensive calcification. However, the intracellular molecular mechanisms that drive these (...) (Circulation)
• 08:00
  Bidirectional Changes in Myocardial 18F-Fluorodeoxyglucose Uptake After Human Ventricular Unloading - Tiberiu A. Pana Jainy Savla Ingrid Kepinski Adam Fairbourn Aneela Afzal Pradeep Mammen Mark Drazner Rathan M. Subramaniam Chao Xing Kathryn A. Morton Stavros G. Drakos Vlad G. Zaha Hesham A. Sadek Aberdeen Cardiovascular and Diabetes Centre, University of Aberdeen, United Kingdom (T.A.P.). Department of Internal Medicine/Cardiology, University of Washington, Seattle (J.S.). Cardiology Division, Department of Internal Medicine (T.A.P., I.K., A.A., P.M., M.D., V.G.Z., H.A.S.); Department of Radiology (A.F., R.M.S.); Eugene McDermott Center for Human Growth and Development (C.X.); Department (...) Circulation
  Circulation, Volume 145, Issue 2, Page 151-154, January 11, 2022. (Circulation)
• 08:00
  Validation of Blood Pressure Device Accuracy: When the Bottom Line Is Not Enough - Jordana B. Cohen Tammy M. Brady Renal-Electrolyte and Hypertension Division (J.B.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. Department of Biostatistics, Epidemiology, and Informatics (J.B.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. Division of Pediatric Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD (T.M.B.). Circulation
  Circulation, Volume 145, Issue 2, Page 94-96, January 11, 2022. (Circulation)
• 08:00
  Celebrating The Next Generation of Cardiovascular Investigators - James A. de Lemos Darren K. McGuire Joseph A. Hill University of Texas Southwestern Medical Center, Dallas (J.A.d.L., D.K.M., J.A.H.). Parkland Health and Hospital System, Dallas, TX (D.K.M.). Circulation
  Circulation, Volume 145, Issue 2, Page 91-93, January 11, 2022. (Circulation)
• 08:00
  The Evolution of Evidence-Based Medicine: When the Magic of the Randomized Clinical Trial Meets Real-World Data - Seng Chan You Harlan M. Krumholz Department of Preventive Medicine, Yonsei University, College of Medicine, Seoul, Korea (S.C.Y.). Center for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT (H.M.K.). Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT (H.M.K.). Department of Health Policy and Management, Yale School of Public Health, New Haven, CT (H.M.K.). Circulation
  Circulation, Volume 145, Issue 2, Page 107-109, January 11, 2022. (Circulation)

7 January

Circulation http://ahajournals.org/

• 05:06
  Common Ancestry-Specific Ion Channel Variants Predispose to Drug-Induced Arrhythmias - Yuko Wada Tao Yang Christian M. Shaffer Laura L. Daniel Andrew M. Glazer Giovanni E. Davogustto Brandon D. Lowery Eric H. Farber-Eger Quinn S. Wells Dan M. Roden Department of Medicine (Y.W., T.Y., C.M.S., L.L.D., A.M.G., G.E.D.), Vanderbilt University Medical Center, Nashville, TN. Vanderbilt Institute for Clinical and Translational Research (B.D.L., E.H.F.-E.), Vanderbilt University Medical Center, Nashville, TN. Departments of Medicine, Pharmacology, and Biomedical Informatics (Q.S.W., D.M.R.), Vanderbilt University Medical Center, Nashville, (...) Circulation
  Circulation, Volume 145, Issue 4, Page 299-308, January 25, 2022. Background:Multiple reports associate the cardiac sodium channel gene (SCN5A) variants S1103Y and R1193Q with type 3 congenital long QT syndrome and drug-induced long QT syndrome. These variants are too common in ancestral (...) (Circulation)

6 January

Circulation http://ahajournals.org/

• 10:27
  ZEB2 Shapes the Epigenetic Landscape of Atherosclerosis - Paul Cheng Robert C. Wirka Lee Shoa Clarke Quanyi Zhao Ramendra Kundu Trieu Nguyen Surag Nair Disha Sharma Hyun-jung Kim Huitong Shi Themistocles Assimes Juyong Brian Kim Anshul Kundaje Thomas Quertermous Division of Cardiovascular Medicine and the Cardiovascular Institute, Stanford, CA (P.C., L.S.C., Q.Z., R.K., T.N., D.S., H.-j.K., H.S., T.A., J.B.K., T.Q.). Division of Cardiology, Departments of Medicine and Cell Biology and Physiology, McAllister Heart Institute, University of North Carolina, Chapel Hill (R.C.W.). Department of Genetics, Stanford University School of Medicine, CA (...) Circulation
  Circulation, Volume 145, Issue 6, Page 469-485, February 8, 2022. Background:Smooth muscle cells (SMCs) transition into a number of different phenotypes during atherosclerosis, including those that resemble fibroblasts and chondrocytes, and make up the majority of cells in the atherosclerotic (...) (Circulation)

5 January

Circulation http://ahajournals.org/

• 03:25
  Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation: Patient-Level Network Meta-Analyses of Randomized Clinical Trials With Interaction Testing by Age and Sex - Anthony P. Carnicelli Hwanhee Hong Stuart J. Connolly John Eikelboom Robert P. Giugliano David A. Morrow Manesh R. Patel Lars Wallentin John H. Alexander M. Cecilia Bahit Alexander P. Benz Erin A. Bohula Tze-Fan Chao Leanne Dyal Michael Ezekowitz Keith A.A. Fox Baris Gencer Jonathan L. Halperin Ziad Hijazi Stefan H. Hohnloser Kaiyuan Hua Elaine Hylek Eri Toda Kato Julia Kuder Renato D. Lopes Kenneth W. Mahaffey Jonas Oldgren Jonathan P. Piccini Christian T. Ruff Jan Steffel Daniel Wojdyla Christopher B. Granger Division of Cardiology (A.P.C., M.R.P., J.H.A., R.D.L., J.P.P., C.B.G.), Duke (...) Circulation
  Circulation, Volume 145, Issue 4, Page 242-255, January 25, 2022. Background:Direct oral anticoagulants (DOACs) are preferred over warfarin for stroke prevention in atrial fibrillation. Meta-analyses using individual patient data offer substantial advantages over study-level data.Methods:We (...) (Circulation)

29 December

Circulation http://ahajournals.org/

• 08:00
  Colchicine in Cardiovascular Disease: In-Depth Review - Spyridon G. Deftereos Frans J. Beerkens Binita Shah George Giannopoulos Dimitrios A. Vrachatis Sotiria G. Giotaki Gerasimos Siasos Johny Nicolas Clare Arnott Sanjay Patel Mark Parsons Jean-Claude Tardif Jason C. Kovacic George D. Dangas Medical School, National Kapodistrian University of Athens, Greece (S.G.D., D.A.V., S.G.G., G.S., G.D.D.). Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, New York (F.J.B., J.N., J.C.K., G.D.D.). VA New York Harbor Healthcare System, New York University School of Medicine, New York (B.S.). Medical School, Aristotelian University, (...) Circulation
  Circulation, Volume 145, Issue 1, Page 61-78, January 4, 2022. Inflammation plays a prominent role in the development of atherosclerosis and other cardiovascular diseases, and anti-inflammatory agents may improve cardiovascular outcomes. For years, colchicine has been used as a safe and (...) (Circulation)
• 08:00
  Dancing Bundles With Stable Sinus Rhythm - Jaya Batra Angelo Biviano Hirad Yarmohammadi Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY. Circulation
  Circulation, Volume 145, Issue 1, Page 84-86, January 4, 2022. (Circulation)
• 08:00
  Expanding the Role of Coronary Computed Tomography Angiography in Interventional Cardiology - Luiz F. Ybarra Nicolo Piazza London Health Sciences Centre, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada (L.F.Y.). Department of Medicine, Division of Cardiology, McGill University Health Centre, Montreal, QC, Canada (N.P.). Circulation
  Circulation, Volume 145, Issue 1, Page 5-7, January 4, 2022. (Circulation)
• 08:00
  Policy Change Needed to Improve Maternal Cardiovascular Health - Keith Churchwell Donald M. Lloyd-Jones Suzette Rochat Harris Laxmi S. Mehta Yale New Haven Hospital New Haven, CT (K.C.). Department of Preventive Medicine, Northwestern University, Chicago, IL (D.M.L-J.). American Heart Association, Dallas, TX (S.R.H.). Division of Cardiology, The Ohio State University Wexner Medical Center, Columbus, OH (L.S.M.). Circulation
  Circulation, Volume 145, Issue 1, Page e1-e3, January 4, 2022. (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 145, Issue 1, Page 79-83, January 4, 2022. (Circulation)
• 08:00
  Circulation Editors and Editorial Board Circulation
  Circulation, Volume 145, Issue 1, Page 1-3, January 4, 2022. (Circulation)
• 08:00
  Continued Refinement of the Treatment for Light-Chain Cardiac Amyloidosis - Justin L. Grodin Larry D. Anderson Ankit Kansagra Divisions of Cardiology (J.L.G.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas. Hematology and Oncology (L.D.A., A.K.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas. Circulation
  Circulation, Volume 145, Issue 1, Page 18-20, January 4, 2022. (Circulation)

22 December

Circulation http://ahajournals.org/

• 11:00
  Association Between Age and Outcomes of Catheter Ablation Versus Medical Therapy for Atrial Fibrillation: Results From the CABANA Trial - Tristram D. Bahnson Anna Giczewska Daniel B. Mark Andrea M. Russo Kristi H. Monahan Hussein R. Al-Khalidi Adam P. Silverstein Jeanne E. Poole Kerry L. Lee Douglas L. Packer Duke Clinical Research Institute, Duke University, Durham, NC (T.D.B., A.G., D.B.M., H.R.A.-K., A.P.S., K.L.L.). Duke Center for Atrial Fibrillation, Duke Health System, Durham, NC (T.D.B.). Cooper University Health System, Camden, NJ (A.M.R.). Mayo Clinic, Rochester, MN (K.H.M., D.L.P.). University of Washington Medical Center, Seattle (...) Circulation
  Circulation, Volume 145, Issue 11, Page 796-804, March 15, 2022. Background:Observational data suggest that catheter ablation may be safe and effective to treat younger and older patients with atrial fibrillation. No large, randomized trial has examined this issue. This report describes (...) (Circulation)

21 December

Circulation http://ahajournals.org/

• 06:48
  Correction to: Abstract 10712: Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning Circulation
  Circulation, Ahead of Print. (Circulation)
• 11:00
  Arrhythmia Variant Associations and Reclassifications in the eMERGE-III Sequencing Study - Andrew M. Glazer Giovanni Davogustto Christian M. Shaffer Carlos G. Vanoye Reshma R. Desai Eric H. Farber-Eger Ozan Dikilitas Ning Shang Jennifer A. Pacheco Tao Yang Ayesha Muhammad Jonathan D. Mosley Sara L. Van Driest Quinn S. Wells Lauren Lee Shaffer Olivia R. Kalash Yuko Wada Sarah Bland Zachary T. Yoneda Devyn W. Mitchell Brett M. Kroncke Iftikhar J. Kullo Gail P. Jarvik Adam S. Gordon Eric B. Larson Teri A. Manolio Tooraj Mirshahi Jonathan Z. Luo Daniel Schaid Bahram Namjou Tarek Alsaied Rajbir Singh Ashutosh Singhal Cong Liu Chunhua Weng George Hripcsak James D. Ralston Elizabeth (...) Circulation
  Circulation, Volume 145, Issue 12, Page 877-891, March 22, 2022. Background:Sequencing Mendelian arrhythmia genes in individuals without an indication for arrhythmia genetic testing can identify carriers of pathogenic or likely pathogenic (P/LP) variants. However, the extent to which these (...) (Circulation)

20 December

Circulation http://ahajournals.org/

• 08:32
  Recognized Outstanding Reviewers for Circulation in 2021 - Darren K. McGuire James A. de Lemos Joseph A. Hill University of Texas Southwestern Medical Center, Dallas (D.K.M., J.A.d.L., J.A.H.). Parkland Health and Hospital System, Dallas, TX (D.K.M.)., Eloisa Arbustini Emelia Benjamin Michael Blaha Barry Borlaug Khadijah Breathett Robert Byrne Alida Caforio Edina Cenko Richard Cheng David Cohen Nancy Cook Leslie Cooper Kieran Docherty John Eikelboom Assam El-Osta Eva Gerdts Bruna Gigante Robert Giugliano Shinichi Goto Christopher Granger Ziad Hijaz Mark Hlatky Michael Holmes Priscilla Hsue Sadiya Khan Susan Kwon Gregory Lewis Douglas Mann Erin (...) Circulation
  Circulation, Volume 145, Issue 1, Page 4-4, January 4, 2022. (Circulation)
• 08:00
  Wide Complex Tachycardia and Syncope in the Emergency Department - Andrés F. Miranda-Arboleda Shireen Mohammad Adrian Baranchuk Division of Cardiology, Kingston Health Science Centre, Queen’s University, Kingston, ON, Canada (A.F.M.-A., S.M., A.B.). Cardiology Department, Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia (A.F.M.-A.). Circulation
  Circulation, Volume 144, Issue 25, Page 2040-2042, December 21, 2021. (Circulation)
• 08:00
  Late-Breaking Science Abstracts and Featured Science Abstracts From the American Heart Association's Scientific Sessions 2021 and Late-Breaking Abstracts in Resuscitation Science From the Resuscitation Science Symposium 2021 Circulation
  Circulation, Volume 144, Issue 25, Page e564-e593, December 21, 2021. (Circulation)
• 08:00
  Liver Cirrhosis and Hepatocellular Carcinoma After the Fontan Operation: Reaching Clarity in the Face of Uncertainty - Christopher Z. Lam Aliya Gulamhusein Rachel M. Wald Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON, Canada (C.Z.L.). Toronto Centre for Liver Disease (A.G.), Toronto General Hospital, ON, Canada. Peter Munk Cardiac Centre (R.M.W.), Toronto General Hospital, ON, Canada. Circulation
  Circulation, Volume 144, Issue 25, Page 1977-1980, December 21, 2021. (Circulation)
• 08:00
  Incidence and Expected Probability of Liver Cirrhosis and Hepatocellular Carcinoma After Fontan Operation - Masaki Nii Ryo Inuzuka Kei Inai Eriko Shimada Tokuko Shinohara Tomomi Kogiso Hiroshi Ono Shinichi Ootsuki Yoshihiko Kurita Atsuhito Takeda Keiichi Hirono Kota Takei Satoshi Yasukochi Tadahiro Yoshikawa Yoshiyuki Furutani Tomohiro Shinozaki Yutaka Matsuyama Hideaki Senzaki Katsutoshi Tokushige Toshio Nakanishi Department of Pediatric Cardiology, Shizuoka Children’s Hospital, Japan (M.N.). Departments of Pediatrics (R.I.), University of Tokyo, Japan. Biostatistics, School of Public Health (Y.M.), University of Tokyo, Japan. Departments of Pediatric Cardiology and Adult Congenital Cardiology (...) Circulation
  Circulation, Volume 144, Issue 25, Page 2043-2045, December 21, 2021. (Circulation)
• 08:00
  From the Literature - Tracy Hampton Circulation
  Circulation, Volume 144, Issue 25, Page 2038-2039, December 21, 2021. (Circulation)
• 08:00
  Centering Equity in Cardiovascular Care - Bridget M. Kuehn Circulation
  Circulation, Volume 144, Issue 25, Page 2035-2037, December 21, 2021. (Circulation)
• 08:00
  Fish Oil Supplements May Increase the Risk for Atrial Fibrillation: What Does This Mean? - Michelle Samuel Stanley Nattel Research Center and Department of Medicine, Montreal Heart Institute, Université de Montréal, Canada (M.S., S.N.). Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen (S.N.). Institut Hospitalo-Universitaire - l’Institut de Rythmologie et Modélisation Cardiaque (IHU LIRYC) and Fondation Bordeaux Université, France (S.N.). Circulation
  Circulation, Volume 144, Issue 25, Page 1991-1994, December 21, 2021. (Circulation)

17 December

Circulation http://ahajournals.org/

• 11:00
  PRDM16 Is a Compact Myocardium-Enriched Transcription Factor Required to Maintain Compact Myocardial Cardiomyocyte Identity in Left Ventricle - Tongbin Wu Zhengyu Liang Zengming Zhang Canzhao Liu Lunfeng Zhang Yusu Gu Kirk L. Peterson Sylvia M. Evans Xiang-Dong Fu Ju Chen Department of Medicine (T.W., Z.Z., C.L., Y.G., K.L.P., S.M.E., J.C.), University of California San Diego, La Jolla. Department of Cellular and Molecular Medicine (Z.L., X.-D.F.), University of California San Diego, La Jolla. Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences (L.Z., S.M.E.), University of California San Diego, La Jolla. Institute of Genomic Medicine (X.-D.F.), University of California San Diego, La (...) Circulation
  Circulation, Volume 145, Issue 8, Page 586-602, February 22, 2022. Background:Left ventricular noncompaction cardiomyopathy (LVNC) was discovered half a century ago as a cardiomyopathy with excessive trabeculation and a thin ventricular wall. In the decades since, numerous studies have (...) (Circulation)

16 December

Circulation http://ahajournals.org/

• 02:13
  DREAM-ICD-II Study - Christian Steinberg Nicolas Dognin Amit Sodhi Catherine Champagne John A. Staples Jean Champagne Zachary W. Laksman Jean-François Sarrazin Matthew T. Bennett Benoit Plourde Marc W. Deyell Jason G. Andrade Karine Roy John A. Yeung-Lai-Wah Nathaniel M. Hawkins Blandine Mondésert Louis Blier Isabelle Nault Gilles O’Hara Andrew D. Krahn François Philippon Santabhanu Chakrabarti Institut universitaire de cardiologie et pneumologie de Québec, Quebec, Canada (C.S., N.D., C.C., J.C., J.-F.S., B.P., K.R., L.B., I.N., G.O., F.P.). Centre for Cardiovascular Innovation, Division of Cardiology (A.S., Z.L., (...) Circulation
  Circulation, Volume 145, Issue 10, Page 742-753, March 8, 2022. Background:Regulatory authorities of most industrialized countries recommend 6 months of private driving restriction after implantation of a secondary prevention implantable cardioverter-defibrillator (ICD). These driving (...) (Circulation)
• 04:53
  AtheroSpectrum Reveals Novel Macrophage Foam Cell Gene Signatures Associated With Atherosclerotic Cardiovascular Disease Risk - Chuan Li Lili Qu Alyssa J. Matz Patrick A. Murphy Yongmei Liu Ani W. Manichaikul Derek Aguiar Stephen S. Rich David M. Herrington David Vu W. Craig Johnson Jerome I. Rotter Wendy S. Post Anthony T. Vella Annabelle Rodriguez-Oquendo Beiyan Zhou Department of Immunology (C.L., L.Q., A.J.M., A.T.V., B.Z.), University of Connecticut, Farmington. Center for Vascular Biology (P.A.M., A.R.-O.), University of Connecticut, Farmington. School of Medicine, and Institute for Systems Genomics (A.T.V., B.Z.), University of Connecticut, Farmington. Department of Medicine, Divisions of Cardiology and (...) Circulation
  Circulation, Volume 145, Issue 3, Page 206-218, January 18, 2022. Background:Whereas several interventions can effectively lower lipid levels in people at risk for atherosclerotic cardiovascular disease (ASCVD), cardiovascular event risks remain, suggesting an unmet medical need to identify (...) (Circulation)

14 December

Circulation http://ahajournals.org/

• 11:00
  Effect of the Glucagon-Like Peptide-1 Receptor Agonists Semaglutide and Liraglutide on Kidney Outcomes in Patients With Type 2 Diabetes: Pooled Analysis of SUSTAIN 6 and LEADER - Ahmed M. Shaman Stephen C. Bain George L. Bakris John B. Buse Thomas Idorn Kenneth W. Mahaffey Johannes F.E. Mann Michael A. Nauck Søren Rasmussen Peter Rossing Benjamin Wolthers Bernard Zinman Vlado Perkovic Sydney School of Public Health, University of Sydney, Australia (A.M.S.). The George Institute for Global Health, The University of New South Wales, Sydney, Australia (A.M.S., V.P.). College of Pharmacy, King Saud University, Riyadh, Saudi Arabia (A.M.S.). Institute of Life Science, Swansea University Medical School, Singleton Hospital, Swansea, United Kingdom (S.C.B.). University of (...) Circulation
  Circulation, Volume 145, Issue 8, Page 575-585, February 22, 2022. Background:We assessed the effect of once-weekly semaglutide and once-daily liraglutide on kidney outcomes in type 2 diabetes.Methods:Pooled (n=12 637) and by-trial data from SUSTAIN 6 (Trial to Evaluate Cardiovascular and Other (...) (Circulation)
• 11:53
  Reading Frame Repair of TTN Truncation Variants Restores Titin Quantity and Functions - Robert Romano Shahnaz Ghahremani Talia Zimmerman Nicholas Legere Ketan Thakar Feria A. Ladha Anthony M. Pettinato J. Travis Hinson University of Connecticut Health Center, Farmington (R.R., F.A.L., A.M.P., J.T.H.). The Jackson Laboratory for Genomic Medicine, Farmington, CT (S.G., T.Z., N.L., K.T., J.T.H.). Circulation
  Circulation, Volume 145, Issue 3, Page 194-205, January 18, 2022. Background:Titin truncation variants (TTNtvs) are the most common inheritable risk factor for dilated cardiomyopathy (DCM), a disease with high morbidity and mortality. The pathogenicity of TTNtvs has been associated with (...) (Circulation)
• 11:43
  Mechanisms of Sinoatrial Node Dysfunction in Heart Failure With Preserved Ejection Fraction - Thassio Mesquita Rui Zhang Jae Hyung Cho Rui Zhang Yen-Nien Lin Lizbeth Sanchez Joshua I. Goldhaber Joseph K. Yu Jialiu A. Liang Weixin Liu Natalia A. Trayanova Eugenio Cingolani Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (T.M., R.Z., J.H.C., R.Z., Y-N.L., L.S., J.I.G., W.L., E.C.). Department of Biomedical Engineering (J.K.Y., J.A.L., N.A.T.), Johns Hopkins University, Baltimore, MD. Alliance for Cardiovascular and Diagnostic and Treatment Innovation (N.A.T.), Johns Hopkins University, Baltimore, (...) Circulation
  Circulation, Volume 145, Issue 1, Page 45-60, January 4, 2022. Background:The ability to increase heart rate during exercise and other stressors is a key homeostatic feature of the sinoatrial node (SAN). When the physiological heart rate response is blunted, chronotropic incompetence limits (...) (Circulation)

13 December

Circulation http://ahajournals.org/

• 08:00
  Response by Trifan et al to Letter Regarding Article, “Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials” - Gabriela Trifan Philip B. Gorelick Fernando D. Testai University of Illinois Chicago (G.T., P.B.G., F.T.D.). Northwestern University, Chicago, IL (P.B.G.). Circulation
  Circulation, Volume 144, Issue 24, Page e493-e494, December 14, 2021. (Circulation)
• 08:00
  Exercise-Induced Cardiac Troponin Elevations: From Underlying Mechanisms to Clinical Relevance - Vincent L. Aengevaeren Aaron L. Baggish Eugene H. Chung Keith George Øyunn Kleiven Alma M.A. Mingels Stein Ørn Rob E. Shave Paul D. Thompson Thijs M.H. Eijsvogels Radboud Institute for Health Sciences, Departments of Physiology (V.L.A., T.M.H.E.), Radboud University Medical Center, Nijmegen, The Netherlands. Cardiology (V.L.A.), Radboud University Medical Center, Nijmegen, The Netherlands. Cardiovascular Performance Program, Massachusetts General Hospital, Boston (A.L.B.). Michigan Medicine, University of Michigan, Ann Arbor (E.H.C.). Research Institute for Sport and Exercise Sciences, (...) Circulation
  Circulation, Volume 144, Issue 24, Page 1955-1972, December 14, 2021. Serological assessment of cardiac troponins (cTn) is the gold standard to assess myocardial injury in clinical practice. A greater magnitude of acutely or chronically elevated cTn concentrations is associated with lower (...) (Circulation)
• 08:00
  Letter by Zheng et al Regarding Article, “Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials” - Feng Zheng Niklas von Spreckelsen Weipeng Hu Department of Neurosurgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China (F.Z., W.H.). Department of Neurosurgery, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Germany (N.v.S.). Circulation
  Circulation, Volume 144, Issue 24, Page e491-e492, December 14, 2021. (Circulation)
• 08:00
  Nano-miR-133a Replacement Therapy Blunts Pressure Overload–Induced Heart Failure - Jessica Modica Vittoria Di Mauro Maria Barandalla-Sobrados Samuel Elias Pineda Chavez Pierluigi Carullo Simona Nemska Achille Anselmo Gianluigi Condorelli Michele Iafisco Michele Miragoli Daniele Catalucci National Research Council–Institute of Genetics and Biomedical Research, Milan Unit, Italy (J.M., V.D.M., M.B.-S., P.C., G.C., M.M., D.C.). IRCCS Humanitas Research Hospital, Rozzano (Milan), Italy (V.D.M., M.B.-S., S.E.P.C., P.C., S.N., A.A., M.M., D.C.). Department of Medicine and Surgery, University of Parma, Italy (S.E.P.C., M.M.). Humanitas University, Pieve Emanuele (Milan), Italy (...) Circulation
  Circulation, Volume 144, Issue 24, Page 1973-1976, December 14, 2021. (Circulation)
• 08:00
  Correction to: Heating Tobacco Sticks Instead of Combusting Conventional Cigarettes and Future Heart Attacks: Still Smoke, and Risk Circulation
  Circulation, Volume 144, Issue 24, Page e550-e550, December 14, 2021. (Circulation)
• 08:00
  Accelerated Epigenetic Aging and Incident Atrial Fibrillation: New Outlook on an Immutable Risk Factor? - Cavin K. Ward-Caviness Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC Circulation
  Circulation, Volume 144, Issue 24, Page 1912-1914, December 14, 2021. (Circulation)

10 December

Circulation http://ahajournals.org/

• 04:12
  Periodic Repolarization Dynamics Identifies ICD Responders in Nonischemic Cardiomyopathy: A DANISH Substudy - Rune Boas Nikolay Sappler Lukas von Stülpnagel Mathias Klemm Ulrik Dixen Jens Jakob Thune Steen Pehrson Lars Køber Jens C. Nielsen Lars Videbæk Jens Haarbo Eva Korup Niels Eske Bruun Axel Brandes Hans Eiskjær Anna M. Thøgersen Berit T. Philbert Jesper Hastrup Svendsen Jacob Tfelt-Hansen Axel Bauer Konstantinos D. Rizas Department of Cardiology, Amager Hvidovre University Hospital, University of Copenhagen, Denmark (R.B., U.D.). Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (R.B., U.D., J.J.T., S.P., L.K., N.E.B., J.H.S.). Department (...) Circulation
  Circulation, Volume 145, Issue 10, Page 754-764, March 8, 2022. Background:Identification of patients with nonischemic cardiomyopathy who may benefit from prophylactic implantation of a cardioverter-defibrillator. We hypothesized that periodic repolarization dynamics (PRD), a marker of (...) (Circulation)

9 December

Circulation http://ahajournals.org/

• 07:40
  Long-Term Follow-Up of DANISH (The Danish Study to Assess the Efficacy of ICDs in Patients With Nonischemic Systolic Heart Failure on Mortality) - Adelina Yafasova Jawad H. Butt Marie B. Elming Jens C. Nielsen Jens Haarbo Lars Videbæk Line L. Olesen Flemming H. Steffensen Niels E. Bruun Hans Eiskjær Axel Brandes Anna M. Thøgersen Kenneth Egstrup Finn Gustafsson Christian Hassager Jesper H. Svendsen Dan E. Høfsten Christian Torp-Pedersen Steen Pehrson Jens J. Thune Lars Køber Department of Cardiology, Copenhagen University Hospital–Rigshospitalet, Denmark (A.Y., J.H.B., M.B.E., F.G., C.H., J.H.S., D.E.H., S.P., L.K.). Department of Internal Medicine (M.B.E.), Zealand University Hospital, Roskilde, Denmark. Department of Cardiology (L.L.O., (...) Circulation
  Circulation, Volume 145, Issue 6, Page 427-436, February 8, 2022. Background:DANISH (The Danish Study to Assess the Efficacy of Implantable Cardioverter Defibrillators [ICDs] in Patients With Nonischemic Systolic Heart Failure on Mortality) found that primary-prevention ICD implantation was not (...) (Circulation)
• 08:00
  The Long-Awaited Revascularization Guidelines Are Out: What’s In Them? - Kendra J. Grubb Ajay J. Kirtane Division of Cardiothoracic Surgery, Emory University, Atlanta, GA (K.J.G.). Division of Cardiology, New York-Presbyterian Hospital/Columbia University Irving Medical Center (A.J.K.). Cardiovascular Research Foundation, NY (A.J.K.). Circulation
  Circulation, Volume 145, Issue 3, Page 155-157, January 18, 2022. (Circulation)
• 08:00
  2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines - Jennifer S. Lawton Jacqueline E. Tamis-Holland Sripal Bangalore Eric R. Bates Theresa M. Beckie James M. Bischoff John A. Bittl Mauricio G. Cohen J. Michael DiMaio Creighton W. Don Stephen E. Fremes Mario F. Gaudino Zachary D. Goldberger Michael C. Grant Jang B. Jaswal Paul A. Kurlansky Roxana Mehran Thomas S. Metkus Lorraine C. Nnacheta Sunil V. Rao Frank W. Sellke Garima Sharma Celina M. Yong Brittany A. Zwischenberger *Writing committee members are required to recuse themselves from voting on sections to which their specific relationships with industry may apply; see Appendix 1 for (...) Circulation
  Circulation, Volume 145, Issue 3, Page e18-e114, January 18, 2022. (Circulation)
• 08:00
  2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines - Jennifer S. Lawton Jacqueline E. Tamis-Holland Sripal Bangalore Eric R. Bates Theresa M. Beckie James M. Bischoff John A. Bittl Mauricio G. Cohen J. Michael DiMaio Creighton W. Don Stephen E. Fremes Mario F. Gaudino Zachary D. Goldberger Michael C. Grant Jang B. Jaswal Paul A. Kurlansky Roxana Mehran Thomas S. Metkus Lorraine C. Nnacheta Sunil V. Rao Frank W. Sellke Garima Sharma Celina M. Yong Brittany A. Zwischenberger *Writing committee members are required to recuse themselves from voting on sections to which their specific relationships with industry may apply; see Appendix 1 of the (...) Circulation
  Circulation, Volume 145, Issue 3, Page e4-e17, January 18, 2022. Aim:The executive summary of the American College of Cardiology/American Heart Association/Society for Cardiovascular Angiography and Interventions coronary artery revascularization guideline provides the top 10 items readers (...) (Circulation)

8 December

Circulation http://ahajournals.org/

• 12:30
  Determinants of Incident Atherosclerotic Cardiovascular Disease Events Among Those With Absent Coronary Artery Calcium: Multi-Ethnic Study of Atherosclerosis - Mahmoud Al Rifai Michael J. Blaha Vijay Nambi Steven J.C. Shea Erin D. Michos Roger S. Blumenthal Christie M. Ballantyne Moyses Szklo Philip Greenland Michael D. Miedema Khurram Nasir Jerome I. Rotter Xiuqing Guo Jie Yao Wendy S. Post Salim S. Virani Section of Cardiology, Baylor College of Medicine, Houston, TX (M.A.R., V.N., C.M.B., S.S.V.). The Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University, Baltimore, MD (M.J.B., E.D.M., R.S.B., W.S.P.). Section of Cardiology, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (V.N., S.S.V.). (...) Circulation
  Circulation, Volume 145, Issue 4, Page 259-267, January 25, 2022. Background:The 2018 American Heart Association/American College of Cardiology/Multisociety cholesterol guideline states that statin therapy may be withheld or delayed among intermediate-risk individuals in the absence of coronary (...) (Circulation)

7 December

Circulation http://ahajournals.org/

• 10:18
  An International Multicenter Cohort Study on ?-Blockers for the Treatment of Symptomatic Children With Catecholaminergic Polymorphic Ventricular Tachycardia - Puck J. Peltenburg Dania Kallas Johan M. Bos Krystien V.V. Lieve Sonia Franciosi Thomas M. Roston Isabelle Denjoy Katrina B. Sorensen Seiko Ohno Ferran Roses-Noguer Takeshi Aiba Alice Maltret Martin J. LaPage Joseph Atallah John R. Giudicessi Sally-Ann B. Clur Nico A. Blom Michael Tanck Fabrice Extramiana Koichi Kato Julien Barc Martin Borggrefe Elijah R. Behr Georgia Sarquella-Brugada Jacob Tfelt-Hansen Esther Zorio Heikki Swan Janneke A.E. Kammeraad Andrew D. Krahn Andrew Davis Frederic Sacher Peter J. Schwartz Jason D. Roberts Jonathan R. Skinner Maarten P. van den Berg Prince J. (...) Circulation
  Circulation, Volume 145, Issue 5, Page 333-344, February 1, 2022. Background:Symptomatic children with catecholaminergic polymorphic ventricular tachycardia (CPVT) are at risk for recurrent arrhythmic events. ?-Blockers decrease this risk, but studies comparing individual ?-blockers in sizeable (...) (Circulation)
• 10:58
  Identification of Drug Transporter Genomic Variants and Inhibitors That Protect Against Doxorubicin-Induced Cardiotoxicity - Tarek Magdy Mariam Jouni Hui-Hsuan Kuo Carly J. Weddle Davi Lyra-Leite Hananeh Fonoudi Marisol Romero-Tejeda Mennat Gharib Hoor Javed Giovanni Fajardo Colin J.D. Ross Bruce C. Carleton Daniel Bernstein Paul W. Burridge Department of Pharmacology, and the Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL (T.M., M.J., H-H.K., C.J.W., D.L-L., H.F., M.R-T., M.G., H.J., P.W.B.). Division of Cardiology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA (G.F., D.B.). British Columbia Children’s Hospital Research Institute (...) Circulation
  Circulation, Volume 145, Issue 4, Page 279-294, January 25, 2022. Background:Multiple pharmacogenomic studies have identified the synonymous genomic variant rs7853758 (G > A, L461L) and the intronic variant rs885004 inSLC28A3(solute carrier family 28 member 3) as statistically associated with a (...) (Circulation)

6 December

Circulation http://ahajournals.org/

• 11:00
  Clinically Suspected Myocarditis Temporally Related to COVID-19 Vaccination in Adolescents and Young Adults: Suspected Myocarditis After COVID-19 Vaccination - Dongngan T. Truong Audrey Dionne Juan Carlos Muniz Kimberly E. McHugh Michael A. Portman Linda M. Lambert Deepika Thacker Matthew D. Elias Jennifer S. Li Olga H. Toro-Salazar Brett R. Anderson Andrew M. Atz C. Monique Bohun M. Jay Campbell Maryanne Chrisant Laura D’Addese Kirsten B. Dummer Daniel Forsha Lowell H. Frank Olivia H. Frosch Sarah K. Gelehrter Therese M. Giglia Camden Hebson Supriya S. Jain Pace Johnston Anita Krishnan Kristin C. Lombardi Brian W. McCrindle Elizabeth C. Mitchell Koichi Miyata Trent Mizzi Robert M. Parker Jyoti K. Patel Christina Ronai Arash A. Sabati Jenna (...) Circulation
  Circulation, Volume 145, Issue 5, Page 345-356, February 1, 2022. Background:Understanding the clinical course and short-term outcomes of suspected myocarditis after the coronavirus disease 2019 (COVID-19) vaccination has important public health implications in the decision to vaccinate (...) (Circulation)
• 11:00
  Methodological Standards for the Design, Implementation, and Analysis of Randomized Trials in Cardiac Surgery: A Scientific Statement From the American Heart Association - Mario Gaudino Joanna Chikwe Emilia Bagiella Deepak L. Bhatt Torsten Doenst Stephen E. Fremes Jennifer Lawton Ruth M. Masterson Creber Robert M. Sade Brittany A. Zwischenberger Circulation
  Circulation, Volume 145, Issue 4, Page e129-e142, January 25, 2022. Cardiac surgery presents specific methodological challenges in the design, implementation, and analysis of randomized controlled trials. The purposes of this scientific statement are to review key standards in cardiac surgery (...) (Circulation)
• 11:00
  Rise in Blood Pressure Observed Among US Adults During the COVID-19 Pandemic - Luke J. Laffin Harvey W. Kaufman Zhen Chen Justin K. Niles Andre R. Arellano Lance A. Bare Stanley L. Hazen Heart Vascular and Thoracic Institute, Cleveland Clinic, OH (L.J.L., S.L.H.). Quest Diagnostics, Secaucus, NJ (H.W.K., Z.C., J.K.N., A.R.A., L.A.B.). Circulation
  Circulation, Volume 145, Issue 3, Page 235-237, January 18, 2022. (Circulation)
• 08:00
  Acute Inferior Wall Myocardial Infarction: What Is the Culprit Artery? - Qinghua Chang Zhaolong Xu Renguang Liu Cardiovascular Institute of the First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning Province, China. Circulation
  Circulation, Volume 144, Issue 23, Page 1893-1895, December 7, 2021. (Circulation)
• 08:00
  Letter by Chiang et al Regarding Article, “Late Outcomes of the RAPID-TnT Randomized Controlled Trial: 0/1-Hour High-Sensitivity Troponin T Protocol in Suspected ACS” - Cho-Han Chiang Cho-Hung Chiang Chien-Chang Lee School of Medicine, National Taiwan University College of Medicine, Taipei (Cho-Han Chiang). Division of General Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Foundation, New Taipei City, Taiwan (Cho-Hung Chiang). Health Data Science Research Group; Department of Emergency Medicine; The Centre for Intelligent Healthcare, National Taiwan University Hospital, Taipei, Taiwan (C.C.L.). Harvard Medical School, Boston, MA (Cho-Han (...) Circulation
  Circulation, Volume 144, Issue 23, Page e457-e458, December 7, 2021. (Circulation)
• 08:00
  Response by Lambrakis and Chew to Letter Regarding Article, “Late Outcomes of the RAPID-TnT Randomized Controlled Trial: 0/1-Hour High-Sensitivity Troponin T Protocol in Suspected ACS” - Kristina Lambrakis Derek P. Chew College of Medicine & Public Health, Flinders University of South Australia, Adelaide (K.L., D.P.C.). South Australian Department of Health, Adelaide (K.L., D.P.C.). Circulation
  Circulation, Volume 144, Issue 23, Page e459-e460, December 7, 2021. (Circulation)
• 08:00
  High Prevalence of Unrecognized Congenital Heart Disease in School-Age Children in Rural China: A Population-Based Echocardiographic Screening Study - Quming Zhao Hongyan Chen Guowen Zhang Weicheng Chen Bing Jia Fang Liu Xiaojing Ma Weili Yan Conway Niu Guoying Huang Pediatric Heart Center (Q.Z., W.C., B.J., F.L., X.M., G.H.), Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, China. Department of Clinical Epidemiology and Clinical Trial Unit (H.C., W.Y.), Children’s Hospital of Fudan University, National Children’s Medical Center, Shanghai, China. Shanghai Key Laboratory of Birth Defects, China (Q.Z., W.C., B.J., F.L., X.M., G.H.). Pediatric Department, Luchun County People’s Hospital, Yunnan Province, (...) Circulation
  Circulation, Volume 144, Issue 23, Page 1896-1898, December 7, 2021. (Circulation)
• 08:00
  Correction to: Novel Criteria for the Observe-Zone of the ESC 0/1h-hs-cTnT Algorithm Circulation
  Circulation, Volume 144, Issue 23, Page e488-e488, December 7, 2021. (Circulation)
• 08:00
  Correction to: Reduced Mitochondrial Oxidactive Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity Circulation
  Circulation, Volume 144, Issue 23, Page e489-e489, December 7, 2021. (Circulation)
• 08:00
  Correction to: Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis Circulation
  Circulation, Volume 144, Issue 23, Page e490-e490, December 7, 2021. (Circulation)
• 08:00
  Persistent Heart Effects of COVID-19 Emphasize the Need for Prevention - Bridget M. Kuehn Circulation
  Circulation, Volume 144, Issue 23, Page 1891-1892, December 7, 2021. (Circulation)
• 08:00
  Navigating the Passage for Better Understanding and Prognosis for Acute Limb Ischemia After Lower-Extremity Revascularization - Mette Søgaard Nikolaj Eldrup Peter Brønnum Nielsen Department of Cardiology, Aalborg University Hospital, Denmark (M.S., P.B.N.). Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Denmark (M.S., P.B.N.). Department of Vascular Surgery, Rigshospitalet, Copenhagen University, Denmark (N.E.). Circulation
  Circulation, Volume 144, Issue 23, Page 1842-1844, December 7, 2021. (Circulation)