30 May

Circulation http://ahajournals.org/

• 08:00
  Cultivating the Research Landscape for Critical Care Cardiology: The Case for Registry-Based Randomized Controlled Trials - Shashank S. Sinha Jason N. Katz David A. Morrow Inova Heart and Vascular Institute, Inova Fairfax Medical Campus, Falls Church, VA (S.S.S.). Division of Cardiovascular Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC (J.N.K.). Levine Cardiac Intensive Care Unit, TIMI (Thrombolysis in Myocardial Infarction) study group, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (...) Circulation
  Circulation, Volume 147, Issue 22, Page 1637-1639, May 30, 2023. (Circulation)
• 08:00
  Letter by Doundoulakis et al Regarding Article, “Programmed Ventricular Stimulation as Additional Primary Prevention Risk Stratification Tool in Arrhythmogenic Right Ventricular Cardiomyopathy” - Ioannis Doundoulakis Konstantinos Tsioufis Konstantinos A. Gatzoulis First Department of Cardiology, National and Kapodistrian University, Hippokration Hospital, Athens, Greece. Circulation
  Circulation, Volume 147, Issue 22, Page 1714-1714, May 30, 2023. (Circulation)
• 08:00
  Titin Missense Variants as a Cause of Familial Dilated Cardiomyopathy - Fernando Domínguez Laura Lalaguna Inés Martínez-Martín Jesús Piqueras-Flores Torsten Bloch Rasmussen Esther Zorio Giovanna Giovinazzo Belen Prados Juan Pablo Ochoa Belen Bornstein Esther González-López Diana Velázquez-Carreras Maria Rosaria Pricolo Francisco Gutiérrez-Agüera Juan Antonio Bernal Elías Herrero-Galán Jorge Alegre-Cebollada Enrique Lara-Pezzi Pablo García-Pavía Heart Failure and Inherited Cardiac Diseases Unit, Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain (F.D., B.B., E.G.-L., P.G.-P.). Centro Nacional de Investigaciones Cardiovasculares (...) Circulation
  Circulation, Volume 147, Issue 22, Page 1711-1713, May 30, 2023. (Circulation)
• 08:00
  Highlights From the Circulation Family of Journals Circulation
  Circulation, Volume 147, Issue 22, Page 1705-1710, May 30, 2023. (Circulation)

26 May

Circulation http://ahajournals.org/

• 11:00
  Immune Regulation of the Liver Through the PCSK9/CD36 Pathway During Heart Transplant Rejection - Xi Zhang Heng Xu Jizhang Yu Jikai Cui Zhang Chen Yuan Li Yuqing Niu Song Wang Shuan Ran Yanqiang Zou Jie Wu Jiahong Xia Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan China. (X.Z., H.X., J.Y., J.C., Z.C., Y.L., Y.N., S.W., S.R., Y.Z., J.W., J.X.) Center for Translational Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan China. (X.Z., J.Y., Z.C., Y.L., Y.N., S.W., S.R., J.W., J.X.) Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:PCSK9 (proprotein convertase subtilisin/kexin 9), which is mainly secreted by the liver, is not only a therapeutic target for hyperlipidemia and cardiovascular disease, but also has been implicated in the immune regulation of infections and tumors. (...) (Circulation)

25 May

Circulation http://ahajournals.org/

• 11:00
  Left Ventricular Systolic Dysfunction in Patients Diagnosed With Hypertrophic Cardiomyopathy During Childhood: Insights From the SHaRe Registry (Sarcomeric Human Cardiomyopathy) - Sarah Abou Alaiwi Thomas M. Roston Peter Marstrand Brian Lee Claggett Victoria N. Parikh Adam S. Helms Jodie Ingles Rachel Lampert Neal K. Lakdawala Michelle Michels Anjali T. Owens Joseph W. Rossano Sara Saberi Dominic J. Abrams Euan A. Ashley Christopher Semsarian John C. Stendahl James S. Ware Erin Miller Thomas D. Ryan Mark W. Russell Sharlene M. Day Iacopo Olivotto Christoffer R. Vissing Carolyn Y. Ho Department of Medicine, Brigham and Women’s Hospital, Boston, MA (S.A.A., T.M.R., B.L.C., N.K.L., C.Y.H.). University of British Columbia, Vancouver, Canada (T.M.R.). Department of (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:The development of left ventricular systolic dysfunction (LVSD) in hypertrophic cardiomyopathy (HCM) is rare but serious and associated with poor outcomes in adults. Little is known about the prevalence, predictors, and prognosis of LVSD in patients (...) (Circulation)
• 11:00
  Association of HIV Infection and Incident Abdominal Aortic Aneurysm Among 143 001 Veterans - Alexandra M. Filipkowski Suman Kundu Svetlana K. Eden Charles W. Alcorn Amy C. Justice Kaku A. So-Armah Hilary A. Tindle Quinn S. Wells Joshua A. Beckman Matthew S. Freiberg Aaron W. Aday Mailman School of Public Health, Columbia University, New York, NY (A.M.F.). Vanderbilt Translational and Clinical Cardiovascular Research Center, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN. (S.K., Q.S.W., J.A.B., M.S.F., A.W.A.) Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN. (S.K.E.) Department of Medicine, Vanderbilt (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:People with HIV (PWH) have an increased risk of cardiovascular disease. Previous cross-sectional data suggest there is a higher prevalence of abdominal aortic aneurysm (AAA) in PWH than in those without HIV. Whether PWH have an increased risk of incident (...) (Circulation)

24 May

Circulation http://ahajournals.org/

• 11:00
  Increasing Equity of Physical Activity Promotion for Optimal Cardiovascular Health in Adults: A Scientific Statement From the American Heart Association - Gerald J. Jerome William R. Boyer Eduardo E. Bustamante Jacob Kariuki Francisco Lopez-Jimenez Amanda E. Paluch Damon L. Swift Kashica J. Webber-Ritchey Bethany Barone Gibbs Circulation
  Circulation, Ahead of Print. Fewer than 1 in 4 adults achieves the recommended amount of physical activity, with lower activity levels reported among some groups. Addressing low levels of physical activity among underresourced groups provides a modifiable target with the potential to improve (...) (Circulation)

22 May

Circulation http://ahajournals.org/

• 03:11
  Effect of Torsemide vs Furosemide on Symptoms and Quality of Life Among Patients Hospitalized for Heart Failure: The TRANSFORM-HF Randomized Clinical Trial - Stephen J. Greene Eric J. Velazquez Kevin J. Anstrom Robert M. Clare Tracy A. DeWald Mitchell A. Psotka Andrew P. Ambrosy Gerin Stevens John J. Rommel Tamas Alexy Fassil Ketema Dong-Yun Kim Patrice Desvigne-Nickens Bertram Pitt Eric L. Eisenstein Robert J. Mentz Duke Clinical Research Institute, Durham, NC; Division of Cardiology, Duke University School of Medicine, Durham, NC Department of Internal Medicine, Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC Duke Clinical (...) Circulation
  Circulation, Ahead of Print. Background:Loop diuretics are a primary therapy for the symptomatic treatment of heart failure (HF), but whether torsemide improves patient symptoms and quality of life better than furosemide remains unknown. As pre-specified secondary endpoints, the TRANSFORM-HF (...) (Circulation)
• 08:00
  New Paradigms to Address Long-Term Exercise Adherence, An Achilles Heel of Lifestyle Interventions - Anthony E. Peters William E. Kraus Robert J. Mentz Division of Cardiology (A.E.P., W.E.K., R.J.M.), Duke University School of Medicine, Durham, NC. Duke Molecular Physiology Institute (W.E.K.), Duke University School of Medicine, Durham, NC. Duke Clinical Research Institute, Durham, NC (A.E.P., R.J.M.). Circulation
  Circulation, Volume 147, Issue 21, Page 1565-1567, May 23, 2023. (Circulation)
• 08:00
  Subepicardial Cardiomyopathy: A Disease Underlying J-Wave Syndromes and Idiopathic Ventricular Fibrillation - Chris Miles Bastiaan J. Boukens Chiara Scrocco Arthur A.M. Wilde Koonlawee Nademanee Michel Haissaguerre Ruben Coronel Elijah R. Behr Cardiovascular Clinical Academic Group, St. George’s University Hospitals’ NHS Foundation Trust and Molecular and Clinical Sciences Institute, St. George’s, University of London, UK (C.M., C.S., E.R.B.). Department of Medical Biology, University of Amsterdam, the Netherlands (B.J.B.). University of Maastricht, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, the Netherlands (B.J.B.). Amsterdam UMC, University of Amsterdam, (...) Circulation
  Circulation, Volume 147, Issue 21, Page 1622-1633, May 23, 2023. Brugada syndrome (BrS), early repolarization syndrome (ERS), and idiopathic ventricular fibrillation (iVF) have long been considered primary electrical disorders associated with malignant ventricular arrhythmia and sudden cardiac (...) (Circulation)
• 08:00
  Telomeres Fuse During Cardiomyocyte Maturation - Esther Aix Alex Gallinat Carla Yago-Díez Javier Lucas Manuel José Gómez Alberto Benguría Patricia Freitag Elizabeth Cortez-Toledo Laura Fernández de Manuel Lucía García-Cuasimodo Héctor Sánchez-Iranzo María C. Montoya Ana Dopazo Fátima Sánchez-Cabo Nadia Mercader Javier E. López Bernd K. Fleischmann Michael Hesse Ignacio Flores Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (E.A., A.G., C.Y.-D., J.L., M.J.G., A.B., L.F.d.M., L.G.-C., H.S.-I., M.C.M., A.D., F.S.-C., N.M., I.F.). Institute of Physiology I, Life and Brain Center, University of Bonn, Germany (P.F., (...) Circulation
  Circulation, Volume 147, Issue 21, Page 1634-1636, May 23, 2023. (Circulation)
• 08:00
  Treatment of Brugada Syndrome in 2023: Know Where You Come From to Know Where You Are Going - Sami Viskin Raphael Rosso Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, Israel. Circulation
  Circulation, Volume 147, Issue 21, Page 1579-1581, May 23, 2023. (Circulation)

19 May

Circulation http://ahajournals.org/

• 11:00
  Bestrophin3 Deficiency in Vascular Smooth Muscle Cells Activates MEKK2/3–MAPK Signaling to Trigger Spontaneous Aortic Dissection - Ting-Ting Zhang Qing-Qing Lei Jie He Xin Guan Xin Zhang Ying Huang Zi-Yue Zhou Rui-Xin Fan Ting Wang Chen-Xi Li Jin-Yan Shang Zhuo-Miao Lin Wan-Li Peng Li-Kai Xia Yu-Ling He Chuan-Ying Hong Jing-Song Ou Rui-Ping Pang Xiao-Ping Fan Hui Huang Jia-Guo Zhou Program of Cardiovascular Research, The Eighth Affiliated Hospital (T.-T.Z., H.H., J.-G.Z.) Department of Pharmacology, Cardiac and Cerebrovascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China. (T.-T.Z., Q.-Q.L., X.G., X.Z., Z.-Y.Z., T.W., J.-Y.S., Z.-M.L., W.-L.P., L.-K.X., Y.-L.H., (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Aortic dissection (AD) is a fatal cardiovascular disorder without effective medications due to unclear pathogenic mechanisms. Bestrophin3 (Best3), the predominant isoform of bestrophin family in vessels, has emerged as critical for vascular pathological (...) (Circulation)

18 May

Circulation http://ahajournals.org/

• 11:01
  Retained Metabolic Flexibility of the Failing Human Heart - William D. Watson Peregrine G. Green Andrew J.M. Lewis Per Arvidsson Giovanni Luigi De Maria Hakan Arheden Einar Heiberg William T. Clarke Christopher T. Rodgers Ladislav Valkovi? Stefan Neubauer Neil Herring Oliver J. Rider Oxford Centre for Magnetic Resonance Research, University of Oxford, UK. (W.D.W., P.G.G., A.J.M.L., P.A., L.V., S.N., O.J.R.) Department for Physiology, Anatomy and Genetics, University of Oxford, UK. (P.G.G., N.H.) Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, UK. (W.T.C.) Department of (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:The failing heart is traditionally described as metabolically inflexible and oxygen starved, causing energetic deficit and contractile dysfunction. Current metabolic modulator therapies aim to increase glucose oxidation by increasing oxygen efficiency of (...) (Circulation)
• 11:01
  Shorter Door-to-Needle Times Are Associated With Better Outcomes After Intravenous Thrombolytic Therapy and Endovascular Thrombectomy for Acute Ischemic Stroke - Shumei Man Nicole Solomon Brian Mac Grory Brooke Alhanti Ken Uchino Jeffrey L. Saver Eric E. Smith Ying Xian Deepak L. Bhatt Lee H. Schwamm Muhammad Shazam Hussain Gregg C. Fonarow Department of Neurology, Cerebrovascular Center, Neurological Institute, Cleveland Clinic, OH (S.M., K.U., M.S.H.). Duke Clinical Research Institute, Duke University, Durham, NC (N.S., B.A.). Department of Neurology, Duke University School of Medicine, Durham, NC (B.M.G.). Department of Neurology, University of California, Los Angeles (J.L.S.). Department of Clinical Neurosciences, Hotchkiss Brain Institute, (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Existing data and clinical trials could not determine whether faster intravenous thrombolytic therapy (IVT) translates into better long-term functional outcomes after acute ischemic stroke among those treated with endovascular thrombectomy (EVT). (...) (Circulation)
• 11:00
  INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10 - Wei Zhang Jinjing Zhao Lin Deng Nestor Ishimwe Jessica Pauli Wen Wu Shengshuai Shan Wolfgang Kempf Margaret D. Ballantyne David Kim Qing Lyu Matthew Bennett Julie Rodor Adam W. Turner Yao Wei Lu Ping Gao Mihyun Choi Ganesh Warthi Ha Won Kim Margarida M. Barroso William B. Bryant Clint L. Miller Neal L. Weintraub Lars Maegdefessel Joseph M. Miano Andrew H Baker Xiaochun Long Vascular Biology Center, Medical College of Georgia at Augusta University (W.Z., N.I., S.S., D.K., Q.L., G.W., H.W.K., W.B.B., N.L.W., J.M.M., X.L.). Department of Molecular and Cellular Physiology, Albany Medical (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Activation of vascular smooth muscle cell (VSMC) inflammation is vital to initiate vascular disease. The role of human-specific long noncoding RNAs in VSMC inflammation is poorly understood.METHODS:Bulk RNA sequencing in differentiated human VSMCs (...) (Circulation)
• 11:00
  Safety and Effectiveness of Pulsed Field Ablation to Treat Atrial Fibrillation: One-Year Outcomes From the MANIFEST-PF Registry - Mohit K. Turagam Petr Neuzil Boris Schmidt Tobias Reichlin Kars Neven Andreas Metzner Jim Hansen Yuri Blaauw Philippe Maury Thomas Arentz Philipp Sommer Ante Anic Frederic Anselme Serge Boveda Tom Deneke Stephan Willems Pepijn van der Voort Roland Tilz Moritoshi Funasako Daniel Scherr Reza Wakili Daniel Steven Josef Kautzner Johan Vijgen Pierre Jais Jan Petru Julian Chun Laurent Roten Anna Füting Marc D. Lemoine Martin Ruwald Bart A Mulder Anne Rollin Heiko Lehrmann Thomas Fink Zrinka Jurisic Corentin Chaumont Raquel Adelino Karin Nentwich Melanie Gunawardene Alexandre Ouss (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Pulsed field ablation is a novel nonthermal cardiac ablation modality using ultra-rapid electrical pulses to cause cell death by a mechanism of irreversible electroporation. Unlike the traditional ablation energy sources, pulsed field ablation has (...) (Circulation)

17 May

Circulation http://ahajournals.org/

• 11:01
  KIDS SAVE LIVES: Basic Life Support Education for Schoolchildren: A Narrative Review and Scientific Statement From the International Liaison Committee on Resuscitation - Daniel C. Schroeder Federico Semeraro Robert Greif Janet Bray Peter Morley Michael Parr Naomi Kondo Nakagawa Taku Iwami Simon-Richard Finke Carolina Malta Hansen Andrew Lockey Marina Del Rios Farhan Bhanji Comilla Sasson Stephen M. Schexnayder Tommaso Scquizzato Wolfgang A. Wetsch Bernd W. Böttiger Circulation
  Circulation, Ahead of Print. BACKGROUND:Basic life support education for schoolchildren has become a key initiative to increase bystander cardiopulmonary resuscitation rates. Our objective was to review the existing literature on teaching schoolchildren basic life support to identify the best (...) (Circulation)
• 11:00
  Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension - Vivek Jani M. Imran Aslam Axel J. Fenwick Weikang Ma Henry Gong Gregory Milburn Devin Nissen Ilton M. Cubero Salazar Olivia Hanselman Monica Mukherjee Marc K. Halushka Kenneth B. Margulies Kenneth Campbell Thomas C. Irving David A. Kass Steven Hsu Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD. (V.J., O.H., D.A.K.) Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD. (V.J., A.J.F., I.M.C.S., M.M., D.A.K., S.H.) Division of Cardiovascular Pathology, Department of Pathology,Johns Hopkins School of Medicine, (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Right ventricular (RV) contractile dysfunction commonly occurs and worsens outcomes in patients with heart failure with reduced ejection fraction and pulmonary hypertension (HFrEF-PH). However, such dysfunction often goes undetected by standard clinical (...) (Circulation)

16 May

Circulation http://ahajournals.org/

• 11:00
  Racial Differences in Quality of Life in Patients With Heart Failure Treated With Sodium–Glucose Cotransporter 2 Inhibitors: A Patient-Level Meta-Analysis of the CHIEF-HF, DEFINE-HF, and PRESERVED-HF Trials - Kashvi Gupta John A. Spertus Mary Birmingham Kensey L. Gosch Mansoor Husain Dalane W. Kitzman Bertram Pitt Sanjiv J. Shah James L. Januzzi Ildiko Lingvay Javed Butler Mikhail Kosiborod David E. Lanfear Saint Luke’s Mid America Heart Institute and University of Missouri–Kansas City (K.G., J.A.S., K.L.G., M.K.). Janssen Scientific Affairs, LLC, Titusville, NJ (M.B.). Ted Rogers Centre for Heart Research, Toronto, Canada (M.H.). Wake Forest University School of Medicine, Winston-Salem, NC (D.W.K.). University of Michigan School of Medicine, Ann Arbor (B.P.). Northwestern University, Chicago, (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Health status outcomes, including symptoms, function, and quality of life, are worse for Black compared with White patients with heart failure. Sodium–glucose cotransporter 2 inhibitors (SGLT2is) reduce cardiovascular mortality and improve health status in (...) (Circulation)

15 May

Circulation http://ahajournals.org/

• 08:00
  Sarcopenia and Cardiovascular Diseases - Abdulla A. Damluji Maha Alfaraidhy Noora AlHajri Namit N. Rohant Manish Kumar Christina Al Malouf Samira Bahrainy Min Ji Kwak Wayne B. Batchelor Daniel E. Forman Michael W. Rich James Kirkpatrick Ashok Krishnaswami Karen P. Alexander Gary Gerstenblith Peggy Cawthon Christopher R. deFilippi Parag Goyal Inova Center of Outcomes Research, Inova Heart and Vascular Institute, Falls Church, VA (A.A.D., W.B.B., C.R.D.). Johns Hopkins University School of Medicine, Baltimore, MD (A.A.D., M.A., G.G.). Cleveland Clinic, Abu Dhabi, United Arab Emirates (N.A.). University of Arizona, Tucson (N.N.R., (...) Circulation
  Circulation, Volume 147, Issue 20, Page 1534-1553, May 16, 2023. Sarcopenia is the loss of muscle strength, mass, and function, which is often exacerbated by chronic comorbidities including cardiovascular diseases, chronic kidney disease, and cancer. Sarcopenia is associated with faster (...) (Circulation)
• 08:00
  Issues With the Design of Randomized Trials of Temporary Mechanical Circulatory Support for Cardiogenic Shock - Jonathan R. Dalzell Department of Transplantation and Mechanical Circulatory Support, Scottish National Advanced Heart Failure Service, Golden Jubilee National Hospital, Glasgow, United Kingdom. Circulation
  Circulation, Volume 147, Issue 20, Page 1489-1491, May 16, 2023. (Circulation)
• 08:00
  Letter by Yang et al Regarding Article, “Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2” - Yuxue Yang Daxin Wang Min Fan Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, China (Y.Y., D.W., M.F.). Department of Cardiology, Medical College, Yangzhou University, China (Y.Y.). Circulation
  Circulation, Volume 147, Issue 20, Page 1560-1561, May 16, 2023. (Circulation)
• 08:00
  Response by Sun et al to Letter Regarding Article, “Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2” - Ling-Yue Sun Yu-Yan Lyu Jun Pu Department of Cardiology, Renji Hospital, School of Medicine, State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China. Circulation
  Circulation, Volume 147, Issue 20, Page 1562-1563, May 16, 2023. (Circulation)
• 08:00
  Association of Severe Hypercholesterolemia and Familial Hypercholesterolemia Genotype With Risk of Coronary Heart Disease - Yiyi Zhang Jacqueline S. Dron Brandon K. Bellows Amit V. Khera Junxiu Liu Pallavi P. Balte Elizabeth C. Oelsner Sami Samir Amr Matthew S. Lebo Anna Nagy Gina M. Peloso Pradeep Natarajan Jerome I. Rotter Cristen Willer Eric Boerwinkle Christie M. Ballantyne Pamela L. Lutsey Myriam Fornage Donald M. Lloyd-Jones Lifang Hou Bruce M. Psaty Joshua C. Bis James S. Floyd Ramachandran S. Vasan Nancy L. Heard-Costa April P. Carson Michael E. Hall Stephen S. Rich Xiuqing Guo Dhruv S. Kazi Sarah D. de Ferranti Andrew E. Moran Division of General Medicine, Columbia University, New York, NY (Y.Z., (...) Circulation
  Circulation, Volume 147, Issue 20, Page 1556-1559, May 16, 2023. (Circulation)
• 08:00
  Correction to: Gremlin Plays a Key Role in the Pathogenesis of Pulmonary Hypertension Circulation
  Circulation, Volume 147, Issue 20, Page e718-e718, May 16, 2023. (Circulation)
• 08:00
  “One Brave Idea” Project Yields New Disease Pathways and Tools to Speed Up Heart Research - Bridget M. Kuehn Circulation
  Circulation, Volume 147, Issue 20, Page 1554-1555, May 16, 2023. (Circulation)
• 08:00
  Raising the Bar for Implementation Science - Rebecca Vigen Sandeep R. Das Division of Cardiology, Department of Medicine, University of Southwestern Medical Center, Dallas, TX (R.V., S.R.D.). Center of Innovation and Value at Parkland, Parkland Health, Dallas, TX (S.R.D.). Circulation
  Circulation, Volume 147, Issue 20, Page 1515-1517, May 16, 2023. (Circulation)

9 May

Circulation http://ahajournals.org/

• 11:00
  Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis - Kyu-Won Cho Mark Andrade Seongho Bae Sangsung Kim Jin Eyun Kim Er Yearn Jang Sangho Lee Ahsan Husain Roy L. Sutliff John W. Calvert Changwon Park Young-sup Yoon Division of Cardiology, Emory University School of Medicine, Atlanta, GA. (K.-W.C., M.A., S.B., S.K., J.E.K., E.Y.J., S.L., A.H., Y.-s.Y.) Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University School of Medicine, Atlanta, GA. (R.L.S.) Department of Medicine, Division of Cardiothoracic Surgery, Department of Surgery, Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA. (J.W.C.) (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Shortly after birth, cardiomyocytes exit the cell cycle and cease proliferation. At present, the regulatory mechanisms for this loss of proliferative capacity are poorly understood. CBX7 (chromobox 7), a polycomb group (PcG) protein, regulates the cell (...) (Circulation)

8 May

Circulation http://ahajournals.org/

• 11:00
  Economic Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients with Severe Aortic Stenosis and Low Surgical Risk: Results from the PARTNER 3 Trial - Benjamin Z. Galper Khaja M. Chinnakondepalli Kaijun Wang Elizabeth A. Magnuson Michael Lu Vinod H. Thourani Susheel Kodali Raj Makkar Howard C. Herrmann Samir Kapadia Mathew Williams John Webb Craig R. Smith Michael J. Mack Martin B. Leon David J. Cohen Mid-Atlantic Permanente Medical Group, McLean, VA (B.Z.G.). Saint-Luke's Mid America Heart Institute, Kansas City, MO (K.M.C., K.W., E.A.M.). Edwards Lifesciences, Irvine, CA (M.L.). Piedmont Heart Institute, Atlanta, GA (V.H.T.). New York-Presbyterian/Columbia University Irving Medical Center, New York (S. Kodali, C.R.S., M.B.L.). (...) Circulation
  Circulation, Volume 147, Issue 21, Page 1594-1605, May 23, 2023. Background:In patients with severe symptomatic aortic stenosis at low surgical risk, transfemoral transcatheter aortic valve replacement (TAVR) with the SAPIEN 3 valve has been shown to reduce the composite of death, stroke, or (...) (Circulation)
• 11:01
  Rivaroxaban for Prevention of Thrombotic Events, Hospitalization, and Death in Outpatients With COVID-19: A Randomized Clinical Trial - Gregory Piazza Alex C. Spyropoulos Judith Hsia Mark Goldin William J. Towner Alan S. Go Todd M. Bull Stephen Weng Concetta Lipardi Elliot S. Barnathan Marc P. Bonaca Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (G.P.). Institute of Health System Science, Feinstein Institutes for Medical Research (A.C.S., M.G.), Northwell Health, Manhasset, NY. Anticoagulation and Clinical Thrombosis Service (A.C.S.), Northwell Health, Manhasset, NY. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, (...) Circulation
  Circulation, Ahead of Print. Background:COVID-19 (coronavirus disease 2019) is associated with heightened risks of venous and arterial thrombosis and hospitalization due to respiratory failure. To assess whether prophylactic anticoagulation can safely reduce the frequency of venous and arterial (...) (Circulation)
• 11:00
  Years of Cardiovascular Complications and Risk Factors in Patients With Type 2 Diabetes: A Nationwide Swedish Cohort Study - Naveed Sattar John McMurray Jan Boren Araz Rawshani Elmir Omerovic Niklas Berg Janita Holminen Kristoffer Skoglund Björn Eliasson Hertzel C. Gerstein Darren K. McGuire Deepak Bhatt Aidin Rawshani Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, UK (N.S., J.M.). Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sweden. (J.B., A.R., E.O., N.B., J.H., K.S., B.E., A.R.) Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, University of Gothenburg, (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:The goal of this work was to investigate trends (2001–2019) for cardiovascular events and cardiometabolic risk factor levels in individuals with type 2 diabetes (T2D) and matched control subjects.METHODS:This study included 679 072 individuals with T2D (...) (Circulation)
• 11:00
  Epidemiology of Diabetes and Atherosclerotic Cardiovascular Disease Among Asian American Adults: Implications, Management, and Future Directions: A Scientific Statement From the American Heart Association - Tak W. Kwan Sally S. Wong Yuling Hong Alka M. Kanaya Sadiya S. Khan Laura L. Hayman Svati H. Shah Francine K. Welty Prakash C. Deedwania Asma Khaliq Latha P. Palaniappan Circulation
  Circulation, Ahead of Print. Asian American individuals make up the fastest growing racial and ethnic group in the United States. Despite the substantial variability that exists in type 2 diabetes and atherosclerotic cardiovascular disease risk among the different subgroups of Asian Americans, (...) (Circulation)
• 08:00
  A Tale of Two Parallel Rhythms - Anshul R. Gupta Abhishek J. Deshmukh Freddy Del-Carpio Munoz Department of Internal Medicine (A.R.G.), Mayo Clinic, Rochester, MN. Department of Cardiovascular Medicine (A.J.D., F.D.-C.M.), Mayo Clinic, Rochester, MN. Circulation
  Circulation, Volume 147, Issue 19, Page 1463-1466, May 9, 2023. (Circulation)
• 08:00
  Social Media and Sports Cardiology: Potential Pitfalls and the Importance of Informed Communication - Jonathan H. Kim Matthew W. Martinez Michael J. Ackerman Emory University School of Medicine, Emory Clinical Cardiovascular Research Institute, Atlanta, GA (J.H.K.). Atlantic Health, Morristown Medical Center, NJ (M.W.M.). Departments of Cardiovascular Medicine, Pediatric and Adolescent Medicine, and Molecular Pharmacology and Experimental Therapeutics; Divisions of Heart Rhythm Services and Pediatric Cardiology; Windland Smith Rice Genetic Heart Rhythm Clinic; and Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, MN (...) Circulation
  Circulation, Volume 147, Issue 19, Page 1419-1421, May 9, 2023. (Circulation)
• 08:00
  Cardioprotection by Peroxidase Activity of Prostaglandin H Synthases in Ischemia/Reperfusion Injury - Guizhu Liu Qian Liu Naifu Wan Xia Shen Hui Cui Cheng Dong Xu Zhang Huiyong Yin Jian Wang Colin D. Funk Ying Yu Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, China (G.L., Q.L., X.Z., Y.Y.). Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical (...) Circulation
  Circulation, Volume 147, Issue 19, Page 1467-1470, May 9, 2023. (Circulation)
• 08:00
  From the Literature - Tracy Hampton Circulation
  Circulation, Volume 147, Issue 19, Page 1461-1462, May 9, 2023. (Circulation)
• 08:00
  Pulsed Field Ablation: Is It Better Than Conventional Thermal Ablation for Treatment of Atrial Fibrillation? - Andrea M. Russo Cooper Medical School of Rowan University, Camden, NJ. Circulation
  Circulation, Volume 147, Issue 19, Page 1433-1435, May 9, 2023. (Circulation)

2 May

Circulation http://ahajournals.org/

• 11:01
  CIB2 Is a Novel Endogenous Repressor of Atrial Remodeling - Yihui Wang Jizheng Wang Ling Shi Xiuyu Chen Desheng Li Chen Cui Kai Yang Minjie Lu Jinhua Huang Lei Zhang Fei Li Jinxi Wang Biyi Chen Bin Wang Duane D. Hall Zhenwei Pan Jiang Hong Long-Sheng Song Lei Song Shihua Zhao Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, China (Y.W., J. Hong). State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (Y.W., Jizheng Wang, X.C., C.C., K.Y., M.L., L.Z., F.L., L.S., S.Z.). Division of Cardiovascular Medicine, (...) Circulation
  Circulation, Ahead of Print. Background:Atrial fibrillation (AF) is a highly prevalent condition that can cause or exacerbate heart failure, is an important risk factor for stroke, and is associated with pronounced morbidity and mortality. Genes uniquely expressed in the atria are known to be (...) (Circulation)
• 11:00
  Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin - Tatsuro Hitsumoto Osamu Tsukamoto Ken Matsuoka Junjun Li Li Liu Yuki Kuramoto Shuichiro Higo Shou Ogawa Noboru Fujino Shohei Yoshida Hidetaka Kioka Hisakazu Kato Hideyuki Hakui Yuki Saito Chisato Okamoto Hijiri Inoue Jo Hyejin Kyoko Ueda Takatsugu Segawa Shunsuke Nishimura Yoshihiro Asano Hiroshi Asanuma Akiyoshi Tani Riyo Imamura Shinsuke Komagawa Toshio Kanai Masayuki Takamura Yasushi Sakata Masafumi Kitakaze Jun-ichi Haruta Seiji Takashima Department of Medical Biochemistry, Osaka University Graduate School of Medicine/Frontier Biosciences, Suita, Osaka, Japan (T.H., O.T., K.M., H. (...) Circulation
  Circulation, Ahead of Print. Background:Cardiac-specific myosin light chain kinase (cMLCK), encoded byMYLK3, regulates cardiac contractility through phosphorylation of ventricular myosin regulatory light chain. However, the pathophysiological and therapeutic implications of cMLCK in human heart (...) (Circulation)

1 May

Circulation http://ahajournals.org/

• 11:00
  Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor - Douglas G. Johns Louis-Charles Campeau Puja Banka An Bautmans Tjerk Bueters Elisabetta Bianchi Danila Branca Paul G. Bulger Inne Crevecoeur Fa-Xiang Ding Robert M. Garbaccio Erik D. Guetschow Yan Guo Sookhee N. Ha Jennifer M. Johnston Hubert Josien Eunkyung A. Kauh Kenneth A. Koeplinger Jeffrey T. Kuethe Eseng Lai Christine L. Lanning Anita Y.H. Lee Li Li Anilkumar G. Nair Edward A. O’Neill S. Aubrey Stoch David A. Thaisrivongs Thomas J. Tucker Petr Vachal Kristien van Dyck Frederic P. Vanhoutte Bram Volckaert Dennis G. Wolford Andy Xu Tian Zhao Dan Zhou Susan Zhou Xiaohong Zhu Hratch J. (...) Circulation
  Circulation, Ahead of Print. Background:Inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9)-low density lipoprotein receptor interaction with injectable monoclonal antibodies or small interfering RNA lowers plasma low density lipoprotein-cholesterol, but despite nearly 2 decades (...) (Circulation)