1 post

18 May

Circulation http://ahajournals.org/

11:00
Indoleamine 2,3-Dioxygenase 1 Deletion–Mediated Kynurenine Insufficiency in Vascular Smooth Muscle Cells Exacerbates Arterial Calcification - Liu Ouyang Changjiang Yu Zhiyong Xie Xiaoyan Su Zengmei Xu Ping Song Jian Li Hui Huang Ye Ding Ming-Hui Zou Center for Molecular and Translational Medicine, Georgia State University, Atlanta (L.Q., C.J.Y., P.S., J.L., Y.D., M.H.Z.). School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, China (Z. Xie, Z. Xu). Department of Nephropathy, Tungwah Hospital of Sun Yat-sen University, Dongguan, China (X.S.). Department of Cardiology, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China (...) Circulation

Circulation, Ahead of Print. BACKGROUND:IDO1 (indoleamine 2,3-dioxygenase 1) is the rate-limiting enzyme for tryptophan metabolism. IDO1 malfunction is involved in the pathogenesis of atherosclerosis. Vascular smooth muscle cells (VSMCs) with an osteogenic phenotype promote calcification and (...) (Circulation)