14 March

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 18:44
  Association of four types of vascular access including arterial superficialization with mortality in maintenance hemodialysis patients: a nationwide cohort study in Japan Am J Nephrol
  Introduction: Vascular access usage varies widely across countries. Previous studies have evaluated the association of clinical outcomes with the three types of vascular access, namely arteriovenous fistula (AVF), arteriovenous graft (AVG), and tunneled and cuffed central venous catheter (...)
• 18:44
  Association of four types of vascular access including arterial superficialization with mortality in maintenance hemodialysis patients: a nationwide cohort study in Japan Am J Nephrol
  Introduction: Vascular access usage varies widely across countries. Previous studies have evaluated the association of clinical outcomes with the three types of vascular access, namely arteriovenous fistula (AVF), arteriovenous graft (AVG), and tunneled and cuffed central venous catheter (...)

9 March

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 11:23
  Contents Vol. 53, 2022 Am J Nephrol
  Am J Nephrol 2022;53:I–X
• 11:22
  Acknowledgement to Reviewers Am J Nephrol
  Am J Nephrol 2022;53:860–861
• 11:23
  Contents Vol. 53, 2022 Am J Nephrol
  Am J Nephrol 2022;53:I–X
• 11:22
  Acknowledgement to Reviewers Am J Nephrol
  Am J Nephrol 2022;53:860–861

8 March

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 08:20
  Triglycerides and Renal Outcomes according to Albuminuria and in Consideration of other Metabolic Syndrome Components in Diabetic US Veterans Am J Nephrol
  Objective: Hypertriglyceridemia, a component of the metabolic syndrome, is a known independent predictor of albuminuria and chronic kidney disease (CKD) in the general population. Previous studies have shown that the relationship of triglycerides with outcomes changes across stages of CKD. Our (...)
• 08:20
  Triglycerides and Renal Outcomes according to Albuminuria and in Consideration of other Metabolic Syndrome Components in Diabetic US Veterans Am J Nephrol
  Objective: Hypertriglyceridemia, a component of the metabolic syndrome, is a known independent predictor of albuminuria and chronic kidney disease (CKD) in the general population. Previous studies have shown that the relationship of triglycerides with outcomes changes across stages of CKD. Our (...)

28 February

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 18:08
  Extremely Low Dose of Erythropoiesis-Stimulating Agent May be Associated with Increased Mortality in Hemodialysis Patients Am J Nephrol
  Introduction: Although high dose erythropoiesis-stimulating agent (ESA) has been shown to increase mortality risk and adverse cardiovascular events in hemodialysis patients, the safety of extremely low dose ESA is unclear. Methods: We retrospectively analyzed the association between ESA dose (...)
• 18:08
  Extremely Low Dose of Erythropoiesis-Stimulating Agent May be Associated with Increased Mortality in Hemodialysis Patients Am J Nephrol
  Introduction: Although high dose erythropoiesis-stimulating agent (ESA) has been shown to increase mortality risk and adverse cardiovascular events in hemodialysis patients, the safety of extremely low dose ESA is unclear. Methods: We retrospectively analyzed the association between ESA dose (...)

13 February

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 16:08
  Clinical Significance of Persistent Hematuria Degrees in Primary IgA Nephropathy: A Propensity Score-Matched Analysis of a 10-Year Follow-Up Cohort Am J Nephrol
  Introduction: The clinical significance of persistent hematuria degrees has not been expounded in primary IgA nephropathy (IgAN) and requires further research. Methods: From January 2003 to May 2022, a total of 684 IgAN patients with persistent hematuria were enrolled to conduct a retrospective (...)
• 14:08
  Characteristics and Graft Outcomes of Kidney Transplant Candidates with Enteric Risk Factors and Elevated Plasma Oxalate Levels Am J Nephrol
  Introduction: This study describes patient characteristics and examines graft function of kidney transplant recipients (without primary hyperoxaluria) with elevated plasma oxalate (POx) and enteric risk factors prior to transplant at our institution. Methods: Kidney transplant recipients (...)
• 14:08
  Characteristics and Graft Outcomes of Kidney Transplant Candidates with Enteric Risk Factors and Elevated Plasma Oxalate Levels Am J Nephrol
  Introduction: This study describes patient characteristics and examines graft function of kidney transplant recipients (without primary hyperoxaluria) with elevated plasma oxalate (POx) and enteric risk factors prior to transplant at our institution. Methods: Kidney transplant recipients (...)
• 16:08
  Clinical Significance of Persistent Hematuria Degrees in Primary IgA Nephropathy: A Propensity Score-Matched Analysis of a 10-Year Follow-Up Cohort Am J Nephrol
  Introduction: The clinical significance of persistent hematuria degrees has not been expounded in primary IgA nephropathy (IgAN) and requires further research. Methods: From January 2003 to May 2022, a total of 684 IgAN patients with persistent hematuria were enrolled to conduct a retrospective (...)

8 February

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 08:58
  Indicators of Kidney Fibrosis in Patients With Type 2 Diabetes and Chronic Kidney Disease Treated With Dulaglutide Am J Nephrol
  Introduction: In the AWARD-7 study in patients with type 2 diabetes and moderate-to-severe chronic kidney disease, once-weekly dulaglutide slowed the decline in estimated glomerular filtration rate (eGFR) and decreased the urine albumin/creatinine ratio compared to insulin glargine at the end (...)
• 08:58
  Indicators of Kidney Fibrosis in Patients With Type 2 Diabetes and Chronic Kidney Disease Treated With Dulaglutide Am J Nephrol
  Introduction: In the AWARD-7 study in patients with type 2 diabetes and moderate-to-severe chronic kidney disease, once-weekly dulaglutide slowed the decline in estimated glomerular filtration rate (eGFR) and decreased the urine albumin/creatinine ratio compared to insulin glargine at the end (...)

3 February

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 13:21
  Regional Variation of Erythropoiesis-Stimulating Agent Hyporesponsiveness in the Global Daprodustat Dialysis Study (ASCEND-D) Am J Nephrol
  Introduction: Hyporesponsiveness to erythropoiesis-stimulating agents (ESAs) affects 10–15% of the chronic dialysis population. We explored baseline characteristics and predictors of ESA hyporesponsiveness in a global randomized cardiovascular outcomes study comparing an investigational (...)
• 13:21
  Regional Variation of Erythropoiesis-Stimulating Agent Hyporesponsiveness in the Global Daprodustat Dialysis Study (ASCEND-D) Am J Nephrol
  Introduction: Hyporesponsiveness to erythropoiesis-stimulating agents (ESAs) affects 10–15% of the chronic dialysis population. We explored baseline characteristics and predictors of ESA hyporesponsiveness in a global randomized cardiovascular outcomes study comparing an investigational (...)

20 January

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 05:16
  Mineralocorticoid Receptor-Associated Mechanisms in Diabetic Kidney Disease and Clinical Significance of Mineralocorticoid Receptor Antagonists Am J Nephrol
  Background: Diabetic kidney disease (DKD) is a common disorder with multiple serious clinical implications, including an increased risk of end-stage kidney disease (ESKD), cardiovascular complications, heart failure, onset or worsening of hypertension, and premature death. Patients with DKD (...)
• 05:16
  Mineralocorticoid Receptor-Associated Mechanisms in Diabetic Kidney Disease and Clinical Significance of Mineralocorticoid Receptor Antagonists Am J Nephrol
  Background: Diabetic kidney disease (DKD) is a common disorder with multiple serious clinical implications, including an increased risk of end-stage kidney disease (ESKD), cardiovascular complications, heart failure, onset or worsening of hypertension, and premature death. Patients with DKD (...)

19 January

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 15:20
  Erratum Am J Nephrol
  Am J Nephrol 2022;53:859
• 15:20
  Erratum Am J Nephrol
  Am J Nephrol 2022;53:859

18 January

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 13:25
  Erratum Am J Nephrol
  Am J Nephrol 2022;53:858
• 13:25
  Erratum Am J Nephrol
  Am J Nephrol 2022;53:858

13 January

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 15:08
  Biomarkers of Covert Acid Stress in Patients with Chronic Kidney Disease: A Cross-Sectional Study Am J Nephrol
  Introduction: Like metabolic acidosis, earlier stages of acid (H+) stress, including an ongoing H+ challenge in the form of dietary H+, without or with steady-state H+ accumulation but with normal plasma total CO2 (PTCO2) (the latter state known as eubicarbonatemic acidosis), are associated (...)
• 15:08
  Biomarkers of Covert Acid Stress in Patients with Chronic Kidney Disease: A Cross-Sectional Study Am J Nephrol
  Introduction: Like metabolic acidosis, earlier stages of acid (H+) stress, including an ongoing H+ challenge in the form of dietary H+, without or with steady-state H+ accumulation but with normal plasma total CO2 (PTCO2) (the latter state known as eubicarbonatemic acidosis), are associated (...)

11 January

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 18:25
  Challenges and Approach to Identifying Individuals with Salt Sensitivity of Blood Pressure Am J Nephrol
  Background: Salt sensitivity of blood pressure (SSBP) is a trait observed in both humans and animals, characterized by an increase in blood pressure (BP) following salt loading or a drop in BP following salt depletion. Summary: This “intermediate” phenotype has been reported in a sizable portion (...)
• 18:25
  Challenges and Approach to Identifying Individuals with Salt Sensitivity of Blood Pressure Am J Nephrol
  Background: Salt sensitivity of blood pressure (SSBP) is a trait observed in both humans and animals, characterized by an increase in blood pressure (BP) following salt loading or a drop in BP following salt depletion. Summary: This “intermediate” phenotype has been reported in a sizable portion (...)
• 10:03
  Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes Am J Nephrol
  Introduction: Diabetes is a leading cause of end-stage kidney disease (ESKD). Biomarkers of tubular health may prognosticate chronic kidney disease (CKD) progression beyond estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR). Methods: We examined (...)
• 10:03
  Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes Am J Nephrol
  Introduction: Diabetes is a leading cause of end-stage kidney disease (ESKD). Biomarkers of tubular health may prognosticate chronic kidney disease (CKD) progression beyond estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR). Methods: We examined (...)
• 15:28
  IgA Nephropathy with Crescents: A Single-Center Experience Am J Nephrol
  Introduction: The presence of crescents in IgA nephropathy (IgAN) has been associated with a poor prognosis. We assess the prognosis of crescents in our patients with IgAN. Methods: IgAN was diagnosed in 73 patients biopsied at Rush University Medical Center from 1992 to 2020, and crescents (...)
• 15:28
  IgA Nephropathy with Crescents: A Single-Center Experience Am J Nephrol
  Introduction: The presence of crescents in IgA nephropathy (IgAN) has been associated with a poor prognosis. We assess the prognosis of crescents in our patients with IgAN. Methods: IgAN was diagnosed in 73 patients biopsied at Rush University Medical Center from 1992 to 2020, and crescents (...)

27 December

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 08:16
  Serum Sclerostin Levels and Mortality in Hemodialysis Patients: An 8-Year Prospective Study Am J Nephrol
  Introduction: Sclerostin is an osteocyte-derived inhibitor of bone formation and is increased in kidney failure. Sclerostin might be involved in the pathogenesis of vascular calcification, but few studies have examined the association between sclerostin and mortality in hemodialysis patients. (...)
• 08:16
  Serum Sclerostin Levels and Mortality in Hemodialysis Patients: An 8-Year Prospective Study Am J Nephrol
  Introduction: Sclerostin is an osteocyte-derived inhibitor of bone formation and is increased in kidney failure. Sclerostin might be involved in the pathogenesis of vascular calcification, but few studies have examined the association between sclerostin and mortality in hemodialysis patients. (...)

21 December

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 13:30
  Proteinuria and Risk for Heart Failure in 55,191 Patients Having History of Cancer Am J Nephrol
  Introduction: We examined the association of proteinuria with the risk for heart failure (HF) and other cardiovascular disease (CVD) events in patients with prior history of breast, colorectal, or stomach cancer using a nationwide population-based database. Methods: We conducted this (...)
• 13:30
  Proteinuria and Risk for Heart Failure in 55,191 Patients Having History of Cancer Am J Nephrol
  Introduction: We examined the association of proteinuria with the risk for heart failure (HF) and other cardiovascular disease (CVD) events in patients with prior history of breast, colorectal, or stomach cancer using a nationwide population-based database. Methods: We conducted this (...)

9 December

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 11:55
  Domains for a Comprehensive Geriatric Assessment of Older Adults with Chronic Kidney Disease: Results from the CRIC Study Am J Nephrol
  Introduction: A comprehensive geriatric assessment (CGA) tailored to the chronic kidney disease (CKD) population would yield a more targeted approach to assessment and care. We aimed to identify domains of a CKD-specific CGA (CKD-CGA), characterize patterns of these domains, and evaluate their (...)
• 11:55
  Domains for a Comprehensive Geriatric Assessment of Older Adults with Chronic Kidney Disease: Results from the CRIC Study Am J Nephrol
  Introduction: A comprehensive geriatric assessment (CGA) tailored to the chronic kidney disease (CKD) population would yield a more targeted approach to assessment and care. We aimed to identify domains of a CKD-specific CGA (CKD-CGA), characterize patterns of these domains, and evaluate their (...)

8 December

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 19:27
  Cardiovascular Risk Prediction in Chronic Kidney Disease Am J Nephrol
  Background: As one of the main complications of chronic kidney disease (CKD), the incidence of cardiovascular disease (CVD) in CKD patients is high. CVD risk is markedly increased even at early stages of CKD, and CVD deaths account for half of all known causes of mortality in end-stage renal (...)
• 09:34
  Hemodialysis Effects on Autonomic Function: Results of Linear and Nonlinear Analysis of Heart Rate Variability at Rest and in Response to Physical and Mental Stress Tests Am J Nephrol
  Introduction: Cardiac arrhythmias are the most common cause of death in hemodialysis. Autonomic dysfunction plays a central role in this arrhythmogenic background. Previous studies on hemodialysis-related changes in heart rate variability (HRV) give contradictory results. This study (...)
• 19:27
  Cardiovascular Risk Prediction in Chronic Kidney Disease Am J Nephrol
  Background: As one of the main complications of chronic kidney disease (CKD), the incidence of cardiovascular disease (CVD) in CKD patients is high. CVD risk is markedly increased even at early stages of CKD, and CVD deaths account for half of all known causes of mortality in end-stage renal (...)
• 09:34
  Hemodialysis Effects on Autonomic Function: Results of Linear and Nonlinear Analysis of Heart Rate Variability at Rest and in Response to Physical and Mental Stress Tests Am J Nephrol
  Introduction: Cardiac arrhythmias are the most common cause of death in hemodialysis. Autonomic dysfunction plays a central role in this arrhythmogenic background. Previous studies on hemodialysis-related changes in heart rate variability (HRV) give contradictory results. This study (...)

7 December

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 09:17
  Factors Affecting the Decision to Initiate Dialysis: A National Survey of United States Nephrologists Am J Nephrol
  Introduction: The percentage of patients initiating dialysis at an estimated glomerular filtration rate (eGFR) ?9 mL/min/1.73 m2 decreased between 2000 and 2018 in the USA. Clinical practice guidelines recommend basing the decision to initiate dialysis primarily on uremic signs and symptoms (...)
• 09:17
  Factors Affecting the Decision to Initiate Dialysis: A National Survey of United States Nephrologists Am J Nephrol
  Introduction: The percentage of patients initiating dialysis at an estimated glomerular filtration rate (eGFR) ?9 mL/min/1.73 m2 decreased between 2000 and 2018 in the USA. Clinical practice guidelines recommend basing the decision to initiate dialysis primarily on uremic signs and symptoms (...)

6 December

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 14:07
  Serum Calciprotein Monomers and Chronic Kidney Disease Progression Am J Nephrol
  Introduction: Elevated levels of fibroblast growth factor-23 (FGF23) in chronic kidney disease (CKD) are associated with progression of CKD. FGF23 inhibits proximal tubular phosphate reabsorption, raising phosphate concentrations in the tubular fluid of functioning nephrons, predisposing to (...)
• 13:49
  Metabolic Basis and Pathogenesis of Skeletal Muscle Dysfunction as Cause of Frailty in Chronic Kidney Disease Am J Nephrol
  Background: Frailty is common in patients with chronic kidney disease (CKD), as is its physical component, phenotypic frailty, and each contributes to CKD-related disability and are associated with increased mortality. Chronic kidney disease has been described as a model of premature aging and (...)
• 14:07
  Serum Calciprotein Monomers and Chronic Kidney Disease Progression Am J Nephrol
  Introduction: Elevated levels of fibroblast growth factor-23 (FGF23) in chronic kidney disease (CKD) are associated with progression of CKD. FGF23 inhibits proximal tubular phosphate reabsorption, raising phosphate concentrations in the tubular fluid of functioning nephrons, predisposing to (...)
• 13:49
  Metabolic Basis and Pathogenesis of Skeletal Muscle Dysfunction as Cause of Frailty in Chronic Kidney Disease Am J Nephrol
  Background: Frailty is common in patients with chronic kidney disease (CKD), as is its physical component, phenotypic frailty, and each contributes to CKD-related disability and are associated with increased mortality. Chronic kidney disease has been described as a model of premature aging and (...)

30 November

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 18:36
  Renal Mechanisms for Hypercalciuria Induced by Metabolic Acidosis Am J Nephrol
  Background: In metabolic acidosis, a negative calcium balance is induced by decreased renal tubular calcium reabsorption. This occurs independently of the action of parathyroid hormone or vitamin D and was attributed to a direct action of metabolic acidosis on the renal tubular cells. The (...)
• 18:36
  Renal Mechanisms for Hypercalciuria Induced by Metabolic Acidosis Am J Nephrol
  Background: In metabolic acidosis, a negative calcium balance is induced by decreased renal tubular calcium reabsorption. This occurs independently of the action of parathyroid hormone or vitamin D and was attributed to a direct action of metabolic acidosis on the renal tubular cells. The (...)
• 18:41
  Overall Adverse Event Profile of Vadadustat for the Treatment of Anemia Associated With Chronic Kidney Disease in Phase 3 Trials Am J Nephrol
  Introduction: Anemia frequently occurs in chronic kidney disease (CKD), is associated with poor quality of life and cardiovascular outcomes, and its treatment represents a considerable economic burden to the healthcare system. Although effective, the current standard of care for the treatment (...)
• 12:52
  Clinical Outcomes of Persistent Severe Acute Kidney Injury among Patients with Kidney Disease Improving Global Outcomes Stage 2 or 3 Acute Kidney Injury Am J Nephrol
  Introduction: The burden of persistent (?3 days) severe AKI (PS-AKI) is poorly described among inpatients with stage 2–3 AKI in the ward or ICU. Quantification could motivate targeted interventions to decrease duration of AKI in these high-risk patients. Methods: This retrospective cohort study (...)
• 18:41
  Overall Adverse Event Profile of Vadadustat for the Treatment of Anemia Associated With Chronic Kidney Disease in Phase 3 Trials Am J Nephrol
  Introduction: Anemia frequently occurs in chronic kidney disease (CKD), is associated with poor quality of life and cardiovascular outcomes, and its treatment represents a considerable economic burden to the healthcare system. Although effective, the current standard of care for the treatment (...)
• 12:52
  Clinical Outcomes of Persistent Severe Acute Kidney Injury among Patients with Kidney Disease Improving Global Outcomes Stage 2 or 3 Acute Kidney Injury Am J Nephrol
  Introduction: The burden of persistent (?3 days) severe AKI (PS-AKI) is poorly described among inpatients with stage 2–3 AKI in the ward or ICU. Quantification could motivate targeted interventions to decrease duration of AKI in these high-risk patients. Methods: This retrospective cohort study (...)

22 July

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 14:41
  Incidence and Importance of Calcium Deposition in Kidney Biopsy Specimens Am J Nephrol
  Introduction: Calcification on native kidney biopsy specimens is often noted by pathologists, but the consequence is unknown. Methods: We searched the pathology reports in the Biopsy Biobank Cohort of Indiana for native biopsy specimens with calcification. Results: Of the 4,364 specimens, 416 (...)

18 July

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 07:52
  Humoral Response and SARS-CoV-2 Infection Risk following the Third and Fourth Doses of the BNT162b2 Vaccine in Dialysis Patients Am J Nephrol
  The optimal SARS-CoV-2 vaccination schedule in dialysis patients and the potential need for a fourth vaccine dose are debatable. We prospectively assessed the humoral responses to three and four doses of BNT162b2 among dialysis patients. The study included 106 dialysis patients; 60 (56.6%) and (...)

29 June

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 10:31
  The Role of Melatonin in Chronic Kidney Disease and Its Associated Risk Factors: A New Tool in Our Arsenal? Am J Nephrol
  Background: The increasing incidence of chronic kidney disease (CKD), as a consequence of the high prevalence of arterial hypertension and type 2 diabetes mellitus (T2DM), warrants the need for developing effective treatment approaches. In this regard, the pineal gland-derived hormone melatonin (...)

23 June

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 10:10
  Utilization of Cystatin C in the Outpatient Setting Am J Nephrol
  Introduction: Serum creatinine is the traditional biomarker for estimating glomerular filtration rate (eGFR). Cystatin C is an alternative biomarker for which estimating equations exist. The use of cystatin C testing, and the interrelationships among the recently revised Chronic Kidney Disease (...)

22 June

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 08:27
  Switch from Hemodialysis to Peritoneal Dialysis: Does the Time Spent on Hemodialysis Impact Outcomes in Peritoneal Dialysis? Am J Nephrol
  Introduction: Switch from hemodialysis (HD) to peritoneal dialysis (PD) is unfrequent, but incentive strategies to perform PD can lead to an increase of these transitions. However, data on transitioning from HD to PD are scarce. We hypothesized that time spent on HD before transfer to PD would (...)

10 June

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 07:24
  Initial eGFR Changes with Ertugliflozin and Associations with Clinical Parameters: Analyses from the VERTIS CV Trial Am J Nephrol
  Introduction: Using data from the ertugliflozin cardiovascular outcomes trial in patients with type 2 diabetes mellitus (VERTIS CV; NCT01986881), associations between the initial estimated glomerular filtration rate (eGFR) “dip” with eGFR slope, glucosuria/natriuresis-related measures, and safety (...)
• 07:23
  Initial Drops in Glomerular Filtration Rate with Certain Drug Classes Retard Kidney Disease Progression Am J Nephrol
  Am J Nephrol

8 June

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 13:47
  Finerenone Reduces Renal ROR?t ?? T Cells and Protects against Cardiorenal Damage Am J Nephrol
  Introduction: Chronic activation of the mineralocorticoid receptor (MR) leads to pathological processes like inflammation and fibrosis during cardiorenal disease. Modulation of immunological processes in the heart or kidney may serve as a mechanistic and therapeutic interface in cardiorenal (...)

7 June

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 14:13
  Bone Turnover, Mineralization, and Volume Estimated by 18F-Sodium Fluoride PET/CT and Biomarkers in Chronic Kidney Disease: Mineral and Bone Disorder Compared with Bone Biopsy Am J Nephrol
  Introduction: Invasive bone biopsy to assess bone metabolism in patients with chronic kidney disease-mineral and bone disorder may be replaced by the noninvasive 18F-NaF PET/CT and biomarkers of bone metabolism. We aimed to compare parameters of bone turnover, mineralization, and volume (...)

3 June

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 08:38
  Renal Megalin mRNA Downregulation Is Associated with CKD Progression in IgA Nephropathy Am J Nephrol
  Introduction: Megalin plays an important role in proximal tubule uptake of filtered proteins. Downregulation and dysfunction of megalin were previously demonstrated in IgA nephropathy (IgAN); however, its relationship to IgAN progression remains unclear. Methods: We measured renal megalin mRNA (...)

25 May

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 07:40
  Change in Urinary Myoinositol/Citrate Ratio Associates with Progressive Loss of Renal Function in ADPKD Patients Am J Nephrol
  Introduction: In autosomal dominant polycystic kidney disease (ADPKD) patients, predicting renal disease progression is important to make a prognosis and to support the clinical decision whether to initiate renoprotective therapy. Conventional markers all have their limitations. Metabolic (...)

24 May

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 13:08
  Going Nuts to Protect Kidneys and to Live Longer with Kidney Disease Am J Nephrol
  Am J Nephrol 2022;53:423–426
• 13:08
  Nut Consumption and Effects on Chronic Kidney Disease and Mortality in the United States Am J Nephrol
  Background: Nuts have been found to have beneficial effects on some diseases, including cardiovascular disease and cancer, in several studies. However, there are few studies to show the effects of nuts on chronic kidney disease (CKD). Thus, we conducted this study to examine the association (...)

18 May

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 14:34
  Presence of Sarcopenia before Kidney Transplantation Is Associated with Poor Outcomes Am J Nephrol
  Introduction: Kidney transplantation is the treatment of choice for patients with renal failure. It is crucial to select which patients may benefit from renal transplantation and which are at high risk for post-transplant complications. Sarcopenia is associated with poor outcome in various (...)

16 May

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 10:28
  Renal Interstitial Inflammation Predicts Nephropathy Progression in IgA Nephropathy: A Two-Center Cohort Study Am J Nephrol
  Introduction: Renal interstitial inflammation often presents in immunoglobulin A nephropathy (IgAN), but its predictive role in kidney disease progression remains controversial. Methods: This retrospective two-center cohort study included 1,420 adult IgAN patients between January 2003 and May (...)

12 May

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 11:09
  Extended-Release Calcifediol Effectively Raises Serum Total 25-Hydroxyvitamin D Even in Overweight Nondialysis Chronic Kidney Disease Patients with Secondary Hyperparathyroidism Am J Nephrol
  Introduction: Obesity increases the risk of vitamin D insufficiency, which exacerbates secondary hyperparathyroidism in chronic kidney disease. Recent studies suggest that serum total 25-hydroxyvitamin D (25OHD) levels of ?50 ng/mL are necessary to produce significant reductions in elevated (...)

11 May

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 14:02
  Pararenal Fat and Renal Dysfunction in Patients without Significant Cardiovascular Disease Am J Nephrol
  Introduction: Accumulation of fat tissue around the kidneys is considered to be a risk factor for chronic kidney disease (CKD). The objective of the study was to investigate the association of pararenal fat tissue (PRFT) and renal dysfunction in patients without clinically significant (...)

10 May

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 14:20
  Urinary Epidermal Growth Factor: A Promising “Next Generation” Biomarker in Kidney Disease Am J Nephrol
  Background: The epidermal growth factor (EGF) is a globular protein that is generated in the kidney, especially in the loop of Henle and the distal convoluted tubule. While EGF is nonexistent or hardly detectable in plasma, it is present in normal people’s urine. Until now, risk stratification (...)

28 April

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 10:43
  Kidney-Metabolic Factors Associated with Cognitive Impairment in Chronic Kidney Disease: A Pilot Study Am J Nephrol
  Introduction: The associations of kidney-metabolic biomarkers with cognitive impairment (CI) beyond the estimated glomerular filtration rate (eGFR, in mL/min/1.73 m2) and albuminuria levels are not well understood. In exploratory analysis, our objective was to determine the extent that three (...)

22 April

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 09:55
  Desidustat in Anemia due to Non-Dialysis-Dependent Chronic Kidney Disease: A Phase 3 Study (DREAM-ND) Am J Nephrol
  Background: Desidustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, is being developed to treat anemia in patients with chronic kidney disease (CKD) without dialysis dependency. Methods: In total, 588 patients with a clinical diagnosis of anemia due to CKD without dialysis (...)
• 09:55
  Desidustat in Anemia due to Dialysis-Dependent Chronic Kidney Disease: A Phase 3 Study (DREAM-D) Am J Nephrol
  Background: A phase 3 study to assess the efficacy and safety of the desidustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, against the epoetin alfa for the treatment of anemia in patients with chronic kidney disease (CKD) with dialysis dependency. Methods: DREAM-D was a (...)
• 09:54
  Debate: Are HIF Stabilizers a Viable Alternative to ESAs in the Management of Anemia in CKD? PRO Am J Nephrol
  Am J Nephrol
• 09:54
  Resistance to Erythropoiesis-Stimulating Agents among Patients on Hemodialysis Is Typically Transient Am J Nephrol
  Introduction: This study examines factors associated with erythropoiesis-stimulating agent (ESA) hyporesponsiveness, the duration of ESA hyporesponsiveness, the frequency of new episodes, and variation across countries. Methods: We used international Dialysis Outcomes and Practice Patterns (...)
• 09:54
  Debate: Are Hydroxylase Inhibitors Stabilizers a Viable Alternative to Erythropoiesis-Stimulating Agents in the Management of Anemia in CKD? CON Am J Nephrol
  Am J Nephrol
• 09:16
  Predictors of Kidney Outcomes of Anti-Glomerular Basement Membrane Disease in a Large Chinese Cohort Am J Nephrol
  Introduction: Anti-glomerular basement membrane (GBM) disease is a rare but the most aggressive form of glomerulonephritis. To dissect the prognostic factors, we retrospectively analyzed the clinical features of a large cohort and compared the clinical features and prognosis during decades. (...)

20 April

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 07:14
  Nurse Caseload and Patient Survival in Hemodialysis Units: A Korean Nationwide Cohort Study Am J Nephrol
  Introduction: The patient-to-nurse ratio is highly variable among dialysis facilities. However, there is little known about the association between nurse caseload and hemodialysis (HD) patient outcomes. We evaluated the association between patient-to-nurse ratio and mortality in the Korean (...)

12 April

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 09:28
  Th17 Cells Participate in Thy1.1 Glomerulonephritis Which Is Ameliorated by Tacrolimus Am J Nephrol
  Introduction: Thy1.1 glomerulonephritis (Thy1.1 GN) in rats is widely used as an experimental model of mesangial proliferative glomerulonephritis (GN). We previously reported that T-helper (Th) cells were accumulated in glomeruli from the early phase of this model and that not Th2 cells but Th1 (...)

4 April

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 09:38
  Effect of Normalizing eGFR to Standard Body Surface Area on Rates of Obesity-Related Hyperfiltration among Diverse Female Adolescents Am J Nephrol
  Introduction: Obesity is more prevalent among African American individuals, increasing the risk for cardiorenal morbidity. We explored interactions between race, BMI, and the risk of hyperfiltration associated with obesity-related glomerulopathy (ORG). Methods: We created a cohort of female (...)

30 March

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 12:53
  New Onset Biopsy-Proven Nephropathies after COVID Vaccination Am J Nephrol
  Introduction: To date, almost 7 billion doses of the different types of vaccine against SARS-CoV-2 have been administered worldwide. Although the severity of new cases of SARS-CoV-2 has progressively decreased, and the pressure on national health systems has declined, the development of de novo (...)

28 March

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 10:15
  Fatigability and the Role of Neuromuscular Impairments in Chronic Kidney Disease Am J Nephrol
  Background: The combination of neuromuscular impairments plus psychosocial aspects of chronic kidney disease (CKD) may predispose these patients to greater risk for experiencing increased levels of fatigability. There has been extensive clinical and scientific interest in the problem of fatigue (...)
• 10:08
  Kidney Transplantation from COVID-19 Deceased Donors: New Hope on the Horizon Am J Nephrol
  Am J Nephrol

25 March

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 09:50
  Vagus Nerve Stimulation: A Potential Therapeutic Role in Childhood Nephrotic Syndrome? Am J Nephrol
  Am J Nephrol

24 March

Am J Nephrol https://www.karger.com/Journal/Home/223979#

• 11:40
  Genetic Etiologies for Chronic Kidney Disease Revealed through Next-Generation Renal Gene Panel Am J Nephrol
  Introduction: Chronic kidney disease (CKD) is a major public health issue in the USA. Identification of monogenic causes of CKD, which are present in ?10% of adult cases, can impact prognosis and patient management. Broad gene panels can provide unbiased testing approaches, which are (...)
• 11:40
  Genetic Testing and FOX News Am J Nephrol
  Am J Nephrol