23 January

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Association analysis of 10 candidate genes causing Mendelian calcium nephrolithiasis in the INCIPE study: a South European general population cohort Clin Kidney J
  ABSTRACTBackgroundIdiopathic calcium nephrolithiasis (ICN) is a common condition with a complex phenotype influenced by both environmental and genetic factors. In our study we investigated the association of allelic variants with the history of nephrolithiasis.MethodsWe genotyped and selected (...)

16 December

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Lung ultrasonography performed by nephrologist: COVID-19 as an opportunity to reveal ultrasound's full potential and usefulness in the dialysis room Clin Kidney J
  ABSTRACTBackgroundInterest in point-of-care ultrasound (POCUS) and lung ultrasound (LUS) is growing in the nephrology and dialysis field, and the number of nephrologists skilled in what is proving to be the “5th pillar of bedside physical examination” is increasing. Patients on hemodialysis (HD) (...)

9 December

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Drugs associated with incident fragility fractures in kidney transplant recipients Clin Kidney J
  ABSTRACTBackgroundThe risk of fragility fractures is high in kidney transplant recipients, and steroids are reportedly a major cause. Other drugs known to induce fragility fractures have been studied in the general population but not in kidney transplant recipients. Here, we investigated the (...)
• 01:00
  Stroke in hemodialysis patients and its association with CHA2DS2-VASC and HAS-BLED scores: a retrospective study Clin Kidney J
  ABSTRACTBackgroundIn the general population, the CHA2DS2-VASC and the HAS-BLED scores are helpful to predict cerebrovascular events and hemorrhage in patients with atrial fibrillation (AF). However, their predictive value remains controversial in the dialysis population. This study aims to (...)

8 December

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Risks and outcomes of critical limb ischemia in hemodialysis patients: a prospective cohort study Clin Kidney J
  ABSTRACTBackgroundPeripheral arterial disease (PAD) is more common in patients receiving maintenance hemodialysis than in the general population. Critical limb ischemia (CLI), the most severe form of PAD, is associated with high amputation and mortality risk. However, few prospective studies (...)

7 December

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Comparison of a chronic kidney disease predictive model for type 2 diabetes mellitus in Malaysia using Cox regression versus machine learning approach Clin Kidney J
  ABSTRACTBackgroundDiabetes is one of the leading causes of chronic kidney disease (CKD) and end-stage renal disease. This study aims to develop and validate different risk predictive models for incident CKD and CKD progression in people with type 2 diabetes (T2D).MethodsWe reviewed a cohort of (...)

6 December

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  A deep learning algorithm to quantify AVF stenosis and predict 6-month primary patency: a pilot study Clin Kidney J
  ABSTRACTBackgroundA deep convolutional neural network (DCNN) model that predicts the degree of arteriovenous fistula (AVF) stenosis and 6-month primary patency (PP) based on AVF shunt sounds was developed, and was compared with various machine learning (ML) models trained on patients’ clinical (...)

24 November

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Impact of immunosuppressive treatment and type of SARS-CoV-2 vaccine on antibody levels after three vaccinations in patients with chronic kidney disease or kidney replacement therapy Clin Kidney J
  ABSTRACTBackgroundPatients with chronic kidney disease (CKD) or kidney replacement therapy demonstrate lower antibody levels after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination compared with healthy controls. In a prospective cohort, we analysed the impact of (...)

18 November

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Kidney function before and after acute kidney injury: a nationwide population-based cohort study Clin Kidney J
  ABSTRACTBackgroundAcute kidney injury (AKI) is a common and serious condition defined by a rapid decline in kidney function. Data on changes in long-term kidney function following AKI are sparse and conflicting. Therefore, we examined the changes in estimated glomerular filtration rate (eGFR) (...)
• 01:00
  Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios: associations with mortality in a haemodialysis cohort Clin Kidney J
  ABSTRACTBackgroundLymphocyte ratios reflect inflammation and have been associated with adverse outcomes in a range of diseases. We sought to determine any association between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and mortality in a haemodialysis cohort, (...)

12 November

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Prevalence of anaemia in adults with chronic kidney disease in a representative sample of the United States population: analysis of the 1999–2018 National Health and Nutrition Examination Survey Clin Kidney J
  ABSTRACTBackgroundPopulation-based estimates of anaemia prevalence in patients with chronic kidney disease (CKD) vary, and data on the prevalence of severe anaemia of CKD are limited. This study examined the prevalence of anaemia and anaemia eligible for erythropoiesis-stimulating agent (ESA) (...)

11 November

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Renal arcuate vein thrombosis–induced acute kidney injury: a rare multiple-Hit–mediated disease Clin Kidney J
  ABSTRACTBackgroundRenal arcuate vein thrombosis (RAVT) is a rare and recently recognized cause of acute kidney injury (AKI) in young adults. However, the precise incidence and underlying pathophysiologic mechanisms leading to AKI in these patients remain elusive.MethodsThis study included all (...)

2 November

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Management of anaemia in French dialysis patients: results from a large epidemiological retrospective study Clin Kidney J
  ABSTRACTBackgroundLimited real-world data are available in Europe, especially France, regarding the therapeutic management of anaemia in patients with dialysis-dependent chronic kidney disease (DD CKD).MethodsThis retrospective, longitudinal, observational study was based on medical records (...)

31 October

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Kidney Donor Profile Index and allograft outcomes: interactive effects of estimated post-transplant survival score and ischaemic time Clin Kidney J
  ABSTRACTBackgroundThe Kidney Donor Profile Index (KDPI) is routinely reported by the donation agencies in Australia. We determined the association between KDPI and short-term allograft loss and assessed if this association was modified by the estimated post-transplant survival (EPTS) score and (...)
• 01:00
  Depression is associated with frailty and lower quality of life in haemodialysis recipients, but not with mortality or hospitalization Clin Kidney J
  ABSTRACTBackgroundFrailty and depression are highly prevalent in haemodialysis recipients, exhibit a reciprocal relationship, and are associated with increased mortality and hospitalization, and lower quality of life. Despite this, there has been little exploration of the relationship between (...)

30 October

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  A comparative post hoc analysis of finerenone and spironolactone in resistant hypertension in moderate-to-advanced chronic kidney disease Clin Kidney J
  ABSTRACTBackgroundMineralocorticoid receptor antagonists (MRAs) reduce systolic blood pressure (SBP) and increase serum potassium concentration ([K+]). This indirect comparison investigated any differences in SBP-lowering and hyperkalemia risk between finerenone, a nonsteroidal MRA, and the (...)

29 October

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Performance of real-time PCR in suspected haemodialysis catheter-related bloodstream infection: a proof-of-concept study Clin Kidney J
  ABSTRACTBackgroundCatheter-related bloodstream infections (CRBIs) remain a major cause of mortality in haemodialysis (HD) patients with central venous catheters (CVCs), especially because of the non-specific symptomatology and the delay in microbiological diagnosis with possible use of (...)
• 02:00
  The Many Faces of NELL1 MN Clin Kidney J
  ABSTRACTNeural tissue encoding protein with EGF-like repeats (NELL1) is a recently discovered target antigen in membranous nephropathy (MN). The initial study showed that most cases of NELL1 MN had no underlying disease associations, i.e. most cases of NELL1 MN were classified as primary MN. (...)
• 02:00
  Collaboration between local nephrologists and the transplant centre ensures good outcomes in post-transplant care Clin Kidney J
  ABSTRACTBackgroundDespite substantial improvements in short-term kidney allograft survival, median long-term survival remains at a standstill. It is unclear whether and to what extent a transplant centre’s post-transplant care influences long-term outcomes.MethodsWe retrospectively analysed 501 (...)
• 02:00
  2009 CKD-EPI glomerular filtration rate estimation in Black individuals outside the United States: a systematic review and meta-analysis Clin Kidney J
  ABSTRACTBackgroundThe 2009 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation is the most used equation to estimate glomerular filtration rate (GFR), with race being a factor thereof, increasing GFR by 16% in self-identified Black persons compared with non-Black persons. (...)

28 October

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Acute and chronic kidney disease and risk of hospital mortality during COVID-19 pandemic waves in the pre-vaccination era Clin Kidney J
  ABSTRACTBackgroundChronic kidney disease (CKD) is a risk factor for death from coronavirus disease 2019 (COVID-19), and COVID-19 may cause acute kidney injury (AKI) which also influences outcomes. There is little information on the independent contribution of CKD and AKI to the risk of death in (...)
• 02:00
  The genetic landscape of autosomal dominant polycystic kidney disease in Kuwait Clin Kidney J
  ABSTRACTBackgroundAutosomal dominant polycystic kidney disease (ADPKD) is the most common renal monogenic disease, characterized by bilateral accumulation of renal fluid-filled cysts leading to progressive renal volume enlargement and gradual impairment of kidney function, often resulting in (...)

22 October

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Management of fracture risk in CKD—traditional and novel approaches Clin Kidney J
  ABSTRACTThe coexistence of osteoporosis and chronic kidney disease (CKD) is an evolving healthcare challenge in the face of increasingly aging populations. Globally, accelerating fracture incidence causes disability, impaired quality of life and increased mortality. Consequently, several novel (...)

21 October

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  No difference in mortality after three different kidney replacement therapy initiation strategies in acute kidney injury Clin Kidney J

19 October

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Microvascular perfusion, perfused boundary region and glycocalyx shedding in patients with autosomal dominant polycystic kidney disease: results from the GlycoScore III study Clin Kidney J
  ABSTRACTBackgroundVascular abnormalities and endothelial dysfunction are part of the spectrum of autosomal dominant polycystic kidney disease (ADPKD). The mechanisms behind these manifestations, including potential effects on the endothelial surface layer (ESL) and glycocalyx integrity, remain (...)
• 02:00
  Development of crescentic membranoproliferative glomerulonephritis after COVID-19 vaccination Clin Kidney J
  ABSTRACTMembranoproliferative glomerulonephritis (MPGN) comprises a histologic pattern of glomerular injury with different underlying diseases. Here we report on a 47-year-old female with rapidly progressive glomerulonephritis (RPGN) on top of a previously diagnosed idiopathic MPGN after (...)

15 October

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Donor liquid biopsy and outcomes in kidney transplantation Clin Kidney J
  ABSTRACTKidney transplantation is the treatment of choice for patients with kidney failure. Priority on the waiting list and optimal donor–recipient matching are guided by mathematical scores, clinical variables and macroscopic observation of the donated organ. Despite the increasing rates of (...)
• 02:00
  Unmet needs in clinical trials in CKD: questions we have not answered and answers we have not questioned Clin Kidney J
  ABSTRACTMany advances have been made in the field of nephrology over the last decade. These include an increasing focus on patient-centred involvement in trials, exploration of innovative trial designs and methodology, the growth of personalized medicine and, most importantly, novel therapeutic (...)
• 02:00
  A prospective study on serum citrate levels and clinical correlations in patients receiving regional citrate anticoagulation Clin Kidney J
  ABSTRACTBackgroundCurrent ways to diagnose citrate accumulation (CA) in patients receiving regional citrate anticoagulation (RCA) continuous renal replacement therapy (CRRT) are confounded by various clinical factors. Serum citrate measurement emerges as a more direct way to diagnose CA, but (...)
• 02:00
  Role of prolyl hydroxylase/HIF-1 signaling in vascular calcification Clin Kidney J
  ABSTRACTMorbidity and mortality of chronic kidney disease (CKD) patients are largely associated with vascular calcification, an actively regulated process in which vascular smooth muscle cells (VSMCs) change into cells similar to osteocytes/chondrocytes, known as trans-differentiation. Cellular (...)

11 October

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Chronic kidney disease as cardiovascular risk factor in routine clinical practice: a position statement by the Council of the European Renal Association Clin Kidney J
  AbstractThe European Society of Cardiology 2021 guideline on cardiovascular (CV) disease (CVD) prevention in clinical practice has major implications for both CV risk screening and kidney health of interest to primary care physicians, cardiologists, nephrol-ogists, and other professionals (...)

10 October

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Temporal trends in prevalence and mortality for chronic kidney disease in China from 1990 to 2019: an analysis of the Global Burden of Disease Study 2019 Clin Kidney J
  ABSTRACTBackgroundThis study aimed to characterize the temporal trends of chronic kidney disease (CKD) burden in China during 1990–2019, evaluate their age, period and cohort effects, and predict the disease burden for the next 10 years.MethodsData were obtained from the Global Burden of Disease (...)

8 October

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  PLEX in AAV-GN: insights from the meta-analysis results and impact on remission induction treatment recommendations Clin Kidney J
  ABSTRACTThe risk of progression to end-stage kidney disease (ESKD) in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and glomerulonephritis (AAV-GN) remains high. At 5 years of follow-up, 14–25% of patients will evolve to ESKD, suggesting that kidney (...)

7 October

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  MicroRNAs: emerging biomarkers and therapeutic targets of bone fragility in chronic kidney disease Clin Kidney J
  ABSTRACTBone fragility is highly prevalent, yet underdiagnosed in patients with chronic kidney disease. Incomplete understanding of the pathophysiology and limitations of current diagnostics contribute to therapeutic hesitation, if not nihilism. This narrative review addresses the question of (...)
• 02:00
  Home dialysis in older adults: challenges and solutions Clin Kidney J
  ABSTRACTThere is a rising demand for dialysis in the older population given the increased numbers of older adults living with chronic kidney disease (CKD) progressing to kidney failure. Home dialysis, i.e. peritoneal dialysis (PD) and home hemodialysis (HHD), has been available for decades, but (...)

23 September

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Donor obesity and weight gain after transplantation: two still overlooked threats to long-term graft survival Clin Kidney J
  ABSTRACTThe effect of donor obesity on kidney transplantation success has long been an overlooked clinical research area. Even though there is no strict guideline in most countries prohibiting donation from obese individuals, most candidates with a body mass index >35–40 kg/m2 are rejected due (...)

21 September

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Urinary angiotensin-converting enzyme 2 and metabolomics in COVID-19-mediated kidney injury Clin Kidney J
  ABSTRACTBackgroundAngiotensin-converting enzyme 2 (ACE2), the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is highly expressed in the kidneys. Beyond serving as a crucial endogenous regulator of the renin–angiotensin system, ACE2 also possess a unique function to (...)

20 September

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Novel strategies in nephrology: what to expect from the future? Clin Kidney J
  ABSTRACTChronic kidney disease (CKD) will become the fifth global case of death by 2040. Its largest impact is on premature mortality but the number of persons with kidney failure requiring renal replacement therapy (RRT) is also increasing dramatically. Current RRT is suboptimal due to the (...)

17 September

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Age and the eGFR-dependent risk for adverse clinical outcomes Clin Kidney J
  ABSTRACTAlthough the relative risk of kidney failure increases with more severe chronic kidney disease (CKD) independent of age, with older age the absolute risk of kidney failure at a given time horizon becomes smaller. In this article, we first review some epidemiological measures of outcome (...)

16 September

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Increasing but insufficient neutralizing activity against Omicron-BA.1 after a second booster dose of mRNA-1273 vaccine in chronic haemodialysis patients Clin Kidney J
  Ethics Committee of the Medical Association of Hesse2021-2437-evBOAmgen10.13039/100002429Abbott Laboratories10.13039/100001316

12 September

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  PoCUS in nephrology: a new tool to improve our diagnostic skills Clin Kidney J
  ABSTRACTPoint-of-Care Ultrasonography (PoCUS) aims to include a fifth pillar (insonation) in the classical physical examination in order to obtain images to answer specific questions by the clinician at the patient's bedside, allowing rapid identification of structural or functional (...)
• 02:00
  Visit-to-visit variability in blood pressure and kidney disease progression in IgA nephropathy Clin Kidney J
  ABSTRACTBackgroundThe visit-to-visit variability (VVV) in blood pressure (BP) is an important risk factor for stroke and coronary heart disease and may also be associated with kidney damage and the development of chronic kidney disease (CKD). Data on the association between VVV in BP and the (...)
• 02:00
  Association between cause of kidney failure and fracture incidence in a national US dialysis population cohort study Clin Kidney J
  ABSTRACTBackgroundWhether fracture rates, overall and by fracture site, vary by cause of kidney failure in patients receiving dialysis is unknown.MethodsUsing the US Renal Data System, we compared fracture rates across seven causes of kidney failure in patients who started dialysis between 1997 (...)

11 September

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Peritoneal dialysis for acute kidney injury: back on the front-line Clin Kidney J
  ABSTRACTPeritoneal dialysis (PD) for acute kidney injury (AKI) has been available for nearly 80 years and has been through periods of use and disuse largely determined by availability of other modalities of kidney replacement therapy and the relative enthusiasm of clinicians. In the past 10 (...)

8 September

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Dysnatremia and risk of bloodstream infection in dialysis patients Clin Kidney J
  ABSTRACTBackgroundEmerging data suggest that sodium disarrays including hyponatremia are potential risk factors for infection ensuing from impairments in host immunity, which may be exacerbated by coexisting conditions (i.e. mucosal membrane and cellular edema leading to breakdown of microbial (...)

25 August

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Comparison of the profiles of patients defined by age-adapted and fixed threshold CKD criteria: a nationwide, cross-sectional study Clin Kidney J
  ABSTRACTBackgroundKidney function declines naturally with advancing age. Therefore an age-adapted estimated glomerular filtration rate (eGFR) threshold has been proposed instead of the fixed threshold for CKD definition. This study aims to describe and compare the profile of CKD patients (...)

24 August

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Hypoxia during maintenance hemodialysis—the critical role of pH Clin Kidney J
  ABSTRACTBackgroundThe impact and management of subclinical hypoxia during hemodialysis is a significant medical challenge. As key determinants of O2 availability and delivery, proposed mechanisms contributing to hypoxia include ischemia, alkalemia and pulmonary leukocyte sequestration. However, (...)
• 02:00
  Vitamin K1 and progression of cardiovascular calcifications in hemodialysis patients: the VitaVasK randomized controlled trial Clin Kidney J
  AbstractBackgroundCardiovascular calcifications are prevented by matrix Gla protein (MGP), a vitamin K–dependent protein. Haemodialysis patients exhibit marked vitamin K deficiency. The randomized, prospective, open-label, multicentre VitaVasK trial analysed whether vitamin K1 supplementation (...)

3 August

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Standardization of serum creatinine is essential for accurate use of unbiased estimated GFR equations: evidence from three cohorts matched on renal function Clin Kidney J
  ABSTRACTBackgroundDifferences in the performance of estimated glomerular filtration rate (eGFR) equations have been attributed to the mathematical form of the equations and to differences between patient demographics and measurement methods. We evaluated differences in serum creatinine (SCr) (...)
• 02:00
  Associations of time-dependent changes in phosphorus levels with cardiovascular diseases in patients undergoing hemodialysis: results from the Japan Dialysis Active Vitamin D (J-DAVID) randomized clinical trial Clin Kidney J
  ABSTRACTBackgroundWhile the risk of exceeding the standard range of phosphorus levels has been investigated, the impact of the degree of fluctuations has not been investigated.MethodsData were derived from the Japan Dialysis Active Vitamin D trial, a 4-year prospective, randomized study (...)
• 02:00
  Probability of chronic kidney disease and associated risk factors in Chinese adults: a cross-sectional study of 9 million Chinese adults in the Meinian Onehealth screening survey Clin Kidney J
  ABSTRACTBackgroundChronic kidney disease (CKD) is an increasing global health problem, but little is known about the age- and sex-specific prevalence of CKD and the associated risk factors in low- and middle-income populations. We examined the age- and sex-specific prevalence of CKD and the (...)

2 August

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Machine learning models for predicting acute kidney injury: a systematic review and critical appraisal Clin Kidney J
  ABSTRACTBackgroundThe number of studies applying machine learning (ML) to predict acute kidney injury (AKI) has grown steadily over the past decade. We assess and critically appraise the state of the art in ML models for AKI prediction, considering performance, methodological soundness, and (...)
• 02:00
  Humoral response to a fourth dose of mRNA vaccine in kidney transplant recipient responders to three doses of mRNA vaccine Clin Kidney J

30 July

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Infectious consequences of the AKI-to-CKD transition Clin Kidney J
  ABSTRACTBackgroundAcute kidney injury (AKI) is associated with short- and long-term complications but the consequences of the AKI-to-CKD transition are still poorly understood. We aimed to evaluate the association between the AKI-to-CKD transition and the long-term risk of infection.MethodsThis (...)

13 July

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Comparison of four medium cut-off dialyzers Clin Kidney J
  ABSTRACTBackgroundRecently, several pharmaceutical companies have developed new medium cut-off (MCO) dialyzers for expanded hemodialysis (HDx). This study aimed to compare the safety and efficacy of four MCO dialyzers, against each other and versus high-flux hemodialysis (HD) and post-dilution (...)

27 June

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  From WEDA to EDTA to ERA: 60 years of supporting European nephrology and counting Clin Kidney J
  ABSTRACTNephrology has evolved from treating kidney failure, first with dialysis and then with kidney transplantation, to identifying and treating early stages of kidney disease and eventually to prevent kidney disease from occurring. Similarly, the name of the European scientific society (...)

22 June

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Point-of-care ultrasonography in nephrology comes of age Clin Kidney J
  ABSTRACTThe physical exam is changing. Many have argued that the physical exam of the 21st century should include point-of-care ultrasound (POCUS). POCUS is being taught in medical schools and has been endorsed by the major professional societies of internal medicine. In this review we describe (...)

16 June

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Reply to ‘Kidney involvement in hereditary transthyretin amyloidosis: is there a role for cystatin C?’ Clin Kidney J

15 June

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Kidney involvement in hereditary transthyretin amyloidosis: is there a role for cystatin C? Clin Kidney J
  Allena PharmaceuticalsAlnylam Pharmaceuticals10.13039/100006400Amgen10.13039/100002429BioHealth ItaliaGilead10.13039/100005564Otsuka Pharmaceutical10.13039/501100007132RocchettaVifor Pharma10.13039/501100006484AkceaSobi10.13039/501100012112Pfizer10.13039/100004319AkceaKedrionCSL (...)
• 02:00
  Decreasing microbiota-derived uremic toxins to improve CKD outcomes Clin Kidney J
  ABSTRACTChronic kidney disease (CKD) is set to become the fifth-leading global cause of death by 2040. This illustrates the many unknowns regarding its pathogenesis and therapy. A key unknown relates to the therapeutic impact of the interaction between CKD and the gut microbiome. The normal gut (...)

30 May

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Welcome editorial by the new CKJ Editor-in-Chief: Facing the future of CKJ with enthusiasm! - Soler M. Clin Kidney J
  Instituto de Salud Carlos III10.13039/501100004587RICORS2040RD21/0005/0016FEDER10.13039/501100002924

25 May

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Left ventricular dysfunction with preserved ejection fraction: the most common left ventricular disorder in chronic kidney disease patients Clin Kidney J
  ABSTRACTChronic kidney disease (CKD) is a risk factor for premature cardiovascular disease. As kidney function declines, the presence of left ventricular abnormalities increases such that by the time kidney replacement therapy is required with dialysis or kidney transplantation, more than (...)

24 May

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Humoral response after SARS-CoV-2 booster vaccination in haemodialysis patients with and without prior infection Clin Kidney J

19 May

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Reply to ‘Stability and compatibility of antibiotics in PD solutions—call for including antibiotics for drug-resistant infections’ Clin Kidney J
• 02:00
  Repurposing drugs for highly prevalent diseases: pentoxifylline, an old drug and a new opportunity for diabetic kidney disease Clin Kidney J
  ABSTRACTDiabetic kidney disease is one of the most frequent complications in patients with diabetes and constitutes a major cause of end-stage kidney disease. The prevalence of diabetic kidney disease continues to increase as a result of the growing epidemic of diabetes and obesity. Therefore, (...)

17 May

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Primary hyperoxaluria: the pediatric nephrologist's point of view - Ben-Shalom E, Garrelfs S, Groothoff J. Clin Kidney J
  ABSTRACTThe clinical presentation of primary hyperoxaluria in children ranges from mildly symptomatic nephrocalcinosis to very early onset end-stage kidney failure with systemic oxalosis, a devastating complication. We review the various manifestations of pediatric hyperoxaluria, treatment (...)
• 02:00
  Primary hyperoxaluria type 1: novel therapies at a glance - Bacchetta J, Lieske J. Clin Kidney J
  ABSTRACTPrimary hyperoxaluria type 1 (PH1) is a rare and severe autosomal recessive disease of oxalate metabolism, resulting from a mutation in the AGXT gene that encodes the hepatic peroxisomal enzyme alanine–glyoxylate aminotransferase (AGT). Until recently, treatment of PH1 was supportive, (...)
• 02:00
  Primary hyperoxaluria type 1: time for prime time? - Bacchetta J, Wood K. Clin Kidney J
  ABSTRACTOxalate crystals in the kidney were first described in 1925. Since then, many major milestones have been reached in the understanding of genetic primary hyperoxaluria(s). Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disease due to a mutation in the AGXT gene, which (...)
• 02:00
  Primary hyperoxaluria: the adult nephrologist's point of view - Moochhala S, Worcester E. Clin Kidney J
  ABSTRACTIn adults, primary hyperoxaluria (PH) does not always present as obviously as in children, leading to delayed or even missed diagnosis. When diagnosed in adulthood, PH usually progresses at a slower rate and the focus is on the prevention of recurrent kidney stones as much as it is on (...)
• 02:00
  Treatment of primary hyperoxaluria type 1 - Gupta A, Somers M, Baum M. Clin Kidney J
  ABSTRACTSupportive treatment for primary hyperoxaluria type 1 (PH1) focuses on high fluid intake and crystallization inhibitors. A subset of patients with specific PH1 genotypes (c.508G>A and c.454T>A) will respond to pyridoxine, defined as a >30% reduction in urinary oxalate excretion. (...)
• 02:00
  Primary hyperoxaluria type 1: pathophysiology and genetics - Fargue S, Acquaviva Bourdain C. Clin Kidney J
  ABSTRACTPrimary hyperoxaluria type 1 (PH1) is a rare genetic form of calcium oxalate kidney stone disease. It is caused by a deficiency in the liver-specific enzyme, alanine:glyoxylate aminotransferase (AGT), a pyridoxal-5?-phosphate (PLP)-dependent enzyme involved in the metabolism of (...)
• 02:00
  Primary hyperoxaluria type 1 in developing countries: novel challenges in a new therapeutic era - Soliman N, Mabrouk S. Clin Kidney J
  ABSTRACTPrimary hyperoxaluria type 1 (PH1) is an autosomal recessive inborn error of metabolism characterized by marked hepatic overproduction of oxalate due to deficiency of hepatic peroxisomal alanine-glyoxylate aminotransferase caused by AGXT gene mutation. One major hallmark of PH1 in (...)
• 02:00
  Primary hyperoxaluria type 1: urologic and therapeutic management - Kohli H, Kurtz M. Clin Kidney J
  ABSTRACTWhile the surgical approaches available in primary hyperoxaluria (PH) are common to all patients requiring intervention for urolithiasis, the indications for treatment and their corresponding toxicities are unique. Being a rare disease, we are guided by case series. This review (...)

12 May

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Renal artery stenting in the correct patients with atherosclerotic renovascular disease: time for a proper renal and cardiovascular outcome study? Clin Kidney J
  ABSTRACTAtherosclerotic renovascular disease (ARVD) represents the most common type of renal artery stenosis. In the last decade, a few large trials failed to demonstrate the superiority of standard medical therapy plus percutaneous transluminal renal angioplasty (PTRA) compared with medical (...)
• 02:00
  Peritoneal catheter insertion: combating barriers through policy change Clin Kidney J
  ABSTRACTBarriers to accessing home dialysis became a matter of life and death for many patients with kidney failure during the coronavirus disease 2019 (COVID-19) pandemic. Peritoneal dialysis (PD) is the more commonly used home therapy option. This article provides a comprehensive analysis of (...)

10 May

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Stability and compatibility of antibiotics in PD solutions—call for including antibiotics for drug-resistant infections Clin Kidney J

6 May

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Idiopathic nephrotic syndrome relapse following COVID-19 vaccination: a series of 25 cases Clin Kidney J
  ABSTRACTBackgroundSeveral cases of idiopathic nephrotic syndrome (INS) relapse following the administration of coronavirus disease 2019 (COVID-19) vaccines have recently been reported, raising questions about the potential relationship between the immune response to COVID-19 vaccination and INS (...)

5 May

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Practical ethical concerns in allocation of pig kidneys to humans Clin Kidney J
  ABSTRACTThe fundamental ethical question of whether pig organs should be transplanted into humans has been settled, as recent surgeries demonstrating proof of concept demonstrate. Other issues need to be considered and reconciled before xenotransplantation of pig kidneys becomes a solution to (...)

30 April

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Which criteria should we use to end isolation in hemodialysis patients with COVID-19? Clin Kidney J
  ABSTRACTSafe and timely discontinuation of quarantine of in-center hemodialysis (HD) patients with a previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a challenging issue for the nephrological community because current guidelines for ending isolation do not (...)

21 April

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Can ketogenic dietary interventions slow disease progression in ADPKD: what we know and what we don't - Ong A, Torra R. Clin Kidney J
  ABSTRACTAutosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease leading to kidney failure. To date, there is no cure for the disease although there is one approved disease-modifying therapy: tolvaptan. In this context, a common question that ADPKD (...)

11 April

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Baseline characteristics and evolution of Brazilian patients with atypical hemolytic uremic syndrome: first report of the Brazilian aHUS Registry Clin Kidney J
  ABSTRACTBackgroundAtypical hemolytic uremic syndrome (aHUS) is an ultra-rare disease. Therefore, studies involving large samples are scarce, making registries powerful tools to evaluate cases. We present herein the first analysis of the Brazilian aHUS Registry (BRaHUS).MethodsAnalysis of (...)
• 02:00
  Semaglutide in type 2 diabetes with chronic kidney disease at high risk progression—real-world clinical practice Clin Kidney J
  ABSTRACTBackgroundSemaglutide [glucagon-like peptide-1 receptor-agonist (GLP-1RA)] has shown nephroprotective effects in previous cardiovascular studies. However, its efficacy and safety in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) have been rarely studied.MethodsThis (...)

9 April

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Dynamics of SARS-CoV-2-Spike-reactive antibody and T-cell responses in chronic kidney disease patients within 3 months after COVID-19 full vaccination Clin Kidney J
  ABSTRACTBackgroundLittle is known regarding the dynamics of antibody and T-cell responses in chronic kidney disease (CKD) following coronavirus disease 2019 (COVID-19) vaccination.MethodsProspective observational cohort study including 144 participants on haemodialysis (HD) (n = 52) or (...)

7 April

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Chronic kidney disease, survival and graft-versus-host-disease-free/relapse-free survival in recipients of allogeneic hematopoietic stem cell transplant Clin Kidney J
  ABSTRACTBackgroundAdvances in allogeneic hematopoietic stem cell transplant (HSCT) have increased patient survival, although substantial treatment-related toxicity remains, including chronic kidney disease (CKD). We assessed the association between CKD and survival and transplant-specific (...)
• 02:00
  Half a century of haemodialysis: two patient journeys Clin Kidney J
  ABSTRACTThe history of renal replacement therapy (RRT) for end-stage kidney disease (ESKD) started in 1960 and has reached, in these six decades, goals initially unforeseen. This report describes two patients who commenced dialysis at the age of 17 and 27, for 53 and 45 years, respectively, (...)

31 March

Clin Kidney J http://ckj.oxfordjournals.org/

• 02:00
  Antibody titers against SARS-CoV-2 spike protein 6 months after a third BNT162b2 vaccine in chronic hemodialysis patients - El Haggan W, Berdin B, El Salhy M. Clin Kidney J
• 02:00
  Farewell from the CKJ Editor-in-Chief: key kidney topics from 2014 to 2021 - Ortiz A, Vinck C. Clin Kidney J
  ABSTRACTThe year 2021 was the last full year of Alberto Ortiz’s editorship at Clinical Kidney Journal (CKJ). On May 2022, Maria José Soler will start her term as the Editor-in-Chief. Over these years, CKJ obtained its first journal impact factor and has consolidated its position among the top (...)

22 March

Clin Kidney J http://ckj.oxfordjournals.org/

• 01:00
  Depression and clinical outcomes in CKD: do anti-depressants play a role? (EQUAL study) Clin Kidney J