RSS : Hypertension & cardio-renal outcomes @
Clin J Am Soc Nephrol
https://cjasn.asnjournals.org/
vendredi 27 janvier 17:24
Articles récents
Préférences
Sources
- - AJKD
- - ↓ Am Heart J
- - Am J Hypertens
- - Am J Kidney Dis
- - ↓ Am J Med
- - Am J Nephrol
- - BMC Nephrol
- - Br Med J (BMJ)
- - Can J Kidney Health Dis
- - Circulation
- - Clin J Am Soc Nephrol
- - Clin Kidney J
- - Curr Opin Endocrinol
- - Curr Opin Nephrol Hypertens
- - Current Opin Cardiol
- - Diabetes
- - Diabetologia
- - Eur Heart J
- - Hypertension
- - ↓ J Am Coll Cardiol
- - J Am Heart Assoc
- - J Am Med Assoc (JAMA)
- - J Am Soc Nephrol
- - J Clin Hypertens
- - J Human Hypertens
- - J Hypertens
- - JAMA Cardiology
- - JAMA Intern Med (aka Arch Intern Med)
- - JCEM
- - Kidney Int
- - Kidney Int Reports
- - Kidney Int Suppl
- - Lancet
- - Lancet - cardiovascular
- - Lancet - Hypertension
- - Lancet Diab Endocrinol
- - Nature Reviews Nephrology
- - Nephrol Dial Transplant
- - ↓ Néphrologie & Thérapeutique (French)
- - Sem Nephrol
- - Stroke
Accueil du site
permalink
216 posts
1 January
Clin J Am Soc Nephrol https://cjasn.asnjournals.org/
-
07:00
No abstract available -- Patient Voice
-
07:00Balancing Risk and Uncertain Benefit in Pharmacotherapy for Pain in Kidney Transplant Recipients - Clin J Am Soc NephrolNo abstract available -- Editorial
-
07:00Improving Physical Functioning for People on Long-Term Dialysis: What Does the Evidence Show? - Clin J Am Soc NephrolNo abstract available -- Editorial
-
07:00
No abstract available -- Editorial
-
07:00Tolvaptan for Autosomal Dominant Polycystic Kidney Disease in Children: Why, Who, and When? - Clin J Am Soc NephrolNo abstract available -- Editorial
-
07:00
No abstract available -- Editorial
-
07:00Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases: A Mendelian Randomization Study - Clin J Am Soc NephrolBackground Fibroblast growth factor-23 (FGF-23) is associated with a range of cardiovascular and noncardiovascular diseases in conventional epidemiological studies, but substantial residual confounding may exist. Mendelian randomization approaches can help control for such confounding. Methods (...) -- Original Article: Chronic Kidney Disease
-
07:00
Background Prediction tools that incorporate self-reported health information could increase CKD awareness, identify modifiable lifestyle risk factors, and prevent disease. We developed and validated a survey-based prediction equation to identify individuals at risk for incident CKD (...) -- Original Article: Chronic Kidney Disease
-
07:00Tolvaptan for Children and Adolescents with Autosomal Dominant Polycystic Kidney Disease: Randomized Controlled Trial - Clin J Am Soc NephrolBackground Tolvaptan slows expansion of kidney volume and kidney function decline in adults with autosomal dominant polycystic kidney disease (ADPKD). Progression during childhood could be treated before irreversible kidney damage occurs, but trial data are lacking. We evaluated the safety and (...) -- Original Article: Cystic Kidney Disease
-
07:00Maintenance of Remission and Risk of Relapse in Myeloperoxidase-Positive ANCA-Associated Vasculitis with Kidney Involvement - Clin J Am Soc NephrolBackground The optimal strategy for remission-maintenance therapy in patients with myeloperoxidase-ANCA (MPO-ANCA)–associated vasculitis is not established. Defining parameters to guide maintenance therapy is required. Methods This was a retrospective cohort study of all patients with (...) -- Original Article: Glomerular and Tubulointerstitial Diseases
-
07:00Global, Regional, and National Burden of CKD due to Glomerulonephritis from 1990 to 2019: A Systematic Analysis from the Global Burden of Disease Study 2019 - Clin J Am Soc NephrolBackground CKD is becoming a major human health concern. Limited quantitative assessments of the burden of CKD due to glomerulonephritis have been performed. We performed a comprehensive analysis of the disease burden to update the epidemiology of this disease. Methods Incidence, prevalence, (...) -- Original Article: Glomerular and Tubulointerstitial Diseases
-
07:00Association of Shear Stress with Subsequent Lumen Remodeling in Hemodialysis Arteriovenous Fistulas - Clin J Am Soc NephrolBackground Blood flow-induced wall shear stress is a strong local regulator of vascular remodeling, but its effects on arteriovenous fistula (AVF) remodeling are unclear. Methods In this prospective cohort study, we used computational fluid dynamics simulations and statistical mixed-effects (...) -- Original Article: Maintenance Dialysis
-
07:00A Randomized Controlled Trial of Whole-Body Vibration on Gait Ability and Balance among Older Hemodialysis Patients - Clin J Am Soc NephrolBackground Gait abnormality is a serious problem among hemodialysis patients. Whole-body vibration is a simple exercise that induces sustained muscular contractions through mechanical vibrations. This training improved gait ability in older adults. We aimed to investigate the effect of (...) -- Original Article: Maintenance Dialysis
-
07:00Gabapentin, Concomitant Prescription of Opioids, and Benzodiazepines among Kidney Transplant Recipients - Clin J Am Soc NephrolBackground Gabapentinoids, commonly used for treating neuropathic pain, may be misused and coprescribed with opioid and benzodiazepine, increasing the risk of mortality and dependency among kidney transplant recipients. Methods We identified adult kidney transplant recipients who enrolled in (...) -- Original Article: Transplantation
-
07:00Short-Term Effects of Potassium Chloride Supplementation on Fibroblast Growth Factor 23 and Phosphate in CKD - Clin J Am Soc NephrolNo abstract available -- Research Letter
-
07:00
No abstract available -- Perspective
7 December
Clin J Am Soc Nephrol https://cjasn.asnjournals.org/
- 19:00
- 19:00
- 19:00
- 19:00
-
19:00
Background and objectives For older patients with kidney failure, lowering symptom burden may be more important than prolonging life. Dialysis initiation may affect individual kidney failure–related symptoms differently, but the change in symptoms before and after start of dialysis has not been (...)
-
19:00Cost-Effectiveness of Dapagliflozin as a Treatment for Chronic Kidney Disease: A Health-Economic Analysis of DAPA-CKD - Clin J Am Soc NephrolBackground and objectives CKD imposes a significant burden on patients and health care providers, particularly upon reaching kidney failure when patients may require KRT. The Dapagliflozin and Prevention of Adverse Outcomes in CKD (DAPA-CKD) trial demonstrated that dapagliflozin, with standard (...)
-
19:00Menstrual Abnormalities and Reproductive Lifespan in Females with CKD: A Systematic Review and Meta-Analysis - Clin J Am Soc NephrolBackground and objectives Menstrual abnormalities and shortened reproductive lifespan are associated with shorter life expectancy and higher cardiovascular and osteoporosis risk in the general population, although the magnitude of these reproductive factor irregularities in females with CKD is (...)
-
19:00Estimated Lifetime Benefit of Combined RAAS and SGLT2 Inhibitor Therapy in Patients with Albuminuric CKD without Diabetes - Clin J Am Soc NephrolBackground and objectives Despite high rates of complications in patients with CKD without diabetes, the implementation of proven therapies in this group remains low. Expressing the clinical benefit of a therapy in terms of extra years free from the disease or death may facilitate (...)
-
19:00
Background and objectives Alport syndrome is an inherited disease characterized by progressive loss of kidney function. We aimed to evaluate the safety and efficacy of bardoxolone methyl in patients with Alport syndrome. Design, setting, participants, & measurements We randomly assigned (...)
-
19:00Nephrology Program Director Protected Time for Program Administration in the United States - Clin J Am Soc NephrolBackground and objectives The Accreditation Council for Graduate Medical Education (ACGME) required that program directors receive 10–20 h/wk of protected time for program administration (including didactic teaching). In July 2022, this was reduced for all internal medicine subspecialties on (...)
-
19:00Development and Validation of a Lifetime Risk Model for Kidney Failure and Treatment Benefit in Type 2 Diabetes: 10-Year and Lifetime Risk Prediction Models - Clin J Am Soc NephrolBackground and objectives Individuals with type 2 diabetes are at a higher risk of developing kidney failure. The objective of this study was to develop and validate a decision support tool for estimating 10-year and lifetime risks of kidney failure in individuals with type 2 diabetes as well (...)
-
19:00A Survey of Environmental Sustainability Practices in Dialysis Facilities in Australia and New Zealand - Clin J Am Soc NephrolBackground and objectives Climate change is the biggest global health threat of the twenty-first century. Health care itself is a significant contributor to greenhouse gas emissions, and dialysis programs contribute disproportionately. Nephrology societies have called for increased recognition (...)
- 19:00
- 19:00
-
19:00
The medical management of the critically ill patient focuses predominantly on treatment of the underlying condition (e.g., sepsis or respiratory failure). However, in the past decade, the importance of initiating early prophylactic treatment for complications arising from care in the intensive (...)
- 19:00
- 19:00
- 19:00
-
19:00
Idiopathic nephrotic syndrome often responds to immunosuppressive treatment. Nevertheless, this syndrome—and the drugs used to treat it—remain important causes of patient morbidity. Idiopathic nephrotic syndrome is usually caused by minimal change disease or FSGS, diseases that primarily affect (...)
1 December
Clin J Am Soc Nephrol https://cjasn.asnjournals.org/
-
07:00
Background and objectives Alport syndrome is an inherited disease characterized by progressive loss of kidney function. We aimed to evaluate the safety and efficacy of bardoxolone methyl in patients with Alport syndrome. Design, setting, participants, & measurements We randomly assigned (...) -- Original Article: Chronic Kidney Disease
-
07:00A Blueprint for Assessing Affordability of SGLT2 Inhibitors in the United States: The Cost-Effectiveness of Dapagliflozin in Three European Countries - Clin J Am Soc NephrolNo abstract available -- Editorial
-
07:00Toward Guideline-Directed Medical Therapy in Nephrology: Lifetime Benefit of RAAS and SGLT2 Inhibition in Nondiabetic Kidney Disease - Clin J Am Soc NephrolNo abstract available -- Editorial
-
07:00
No abstract available -- Editorial
-
07:00
No abstract available -- Editorial
-
07:00
Background and objectives For older patients with kidney failure, lowering symptom burden may be more important than prolonging life. Dialysis initiation may affect individual kidney failure–related symptoms differently, but the change in symptoms before and after start of dialysis has not been (...) -- Original Article: Chronic Kidney Disease
-
07:00Cost-Effectiveness of Dapagliflozin as a Treatment for Chronic Kidney Disease: A Health-Economic Analysis of DAPA-CKD - Clin J Am Soc NephrolBackground and objectives CKD imposes a significant burden on patients and health care providers, particularly upon reaching kidney failure when patients may require KRT. The Dapagliflozin and Prevention of Adverse Outcomes in CKD (DAPA-CKD) trial demonstrated that dapagliflozin, with standard (...) -- Original Article: Chronic Kidney Disease
-
07:00Menstrual Abnormalities and Reproductive Lifespan in Females with CKD: A Systematic Review and Meta-Analysis - Clin J Am Soc NephrolBackground and objectives Menstrual abnormalities and shortened reproductive lifespan are associated with shorter life expectancy and higher cardiovascular and osteoporosis risk in the general population, although the magnitude of these reproductive factor irregularities in females with CKD is (...) -- Original Article: Chronic Kidney Disease
-
07:00Estimated Lifetime Benefit of Combined RAAS and SGLT2 Inhibitor Therapy in Patients with Albuminuric CKD without Diabetes - Clin J Am Soc NephrolBackground and objectives Despite high rates of complications in patients with CKD without diabetes, the implementation of proven therapies in this group remains low. Expressing the clinical benefit of a therapy in terms of extra years free from the disease or death may facilitate (...) -- Original Article: Chronic Kidney Disease
-
07:00Nephrology Program Director Protected Time for Program Administration in the United States - Clin J Am Soc NephrolBackground and objectives The Accreditation Council for Graduate Medical Education (ACGME) required that program directors receive 10–20 h/wk of protected time for program administration (including didactic teaching). In July 2022, this was reduced for all internal medicine subspecialties on the (...) -- Original Article: Clinical Nephrology
-
07:00Development and Validation of a Lifetime Risk Model for Kidney Failure and Treatment Benefit in Type 2 Diabetes: 10-Year and Lifetime Risk Prediction Models - Clin J Am Soc NephrolBackground and objectives Individuals with type 2 diabetes are at a higher risk of developing kidney failure. The objective of this study was to develop and validate a decision support tool for estimating 10-year and lifetime risks of kidney failure in individuals with type 2 diabetes as well (...) -- Original Article: Diabetes and the Kidney
-
07:00A Survey of Environmental Sustainability Practices in Dialysis Facilities in Australia and New Zealand - Clin J Am Soc NephrolBackground and objectives Climate change is the biggest global health threat of the twenty-first century. Health care itself is a significant contributor to greenhouse gas emissions, and dialysis programs contribute disproportionately. Nephrology societies have called for increased recognition (...) -- Original Article: Maintenance Dialysis
-
07:00Effect of Furosemide on Proximal Tubular Secretion of Organic Solutes in Patients Receiving Hemodialysis - Clin J Am Soc NephrolNo abstract available -- Research Letter
-
07:00Correction: Use and Outcomes of Induction Therapy in Well-Matched Kidney Transplant Recipients Clin J Am Soc NephrolNo abstract available -- Erratum
-
07:00
The medical management of the critically ill patient focuses predominantly on treatment of the underlying condition (e.g., sepsis or respiratory failure). However, in the past decade, the importance of initiating early prophylactic treatment for complications arising from care in the intensive (...) -- Critical Care Nephrology and Acute Kidney Injury
-
07:00
No abstract available -- Kidney Case Conference: How I Treat
-
07:00
No abstract available -- Perspective
-
07:00
No abstract available -- Perspective
-
07:00
Idiopathic nephrotic syndrome often responds to immunosuppressive treatment. Nevertheless, this syndrome—and the drugs used to treat it—remain important causes of patient morbidity. Idiopathic nephrotic syndrome is usually caused by minimal change disease or FSGS, diseases that primarily affect (...) -- Review
8 November
Clin J Am Soc Nephrol https://cjasn.asnjournals.org/
-
07:00Accepting Living Kidney Donors with Preexisting Diabetes Mellitus: A Perspective on the Recent OPTN Policy Change—July 2022 - Clin J Am Soc NephrolNo abstract available -- Perspective
1 November
Clin J Am Soc Nephrol https://cjasn.asnjournals.org/
-
06:00
No abstract available -- Patient Voice
-
06:00Understanding Public Perspectives on Opt-Out Deceased Donor Transplant Policy: Ethically Obligatory and Practically Necessary - Clin J Am Soc NephrolNo abstract available -- Editorial
-
06:00Integrating PROMs in Routine Dialysis Care: The Devil Is in the (Implementation) Details - Clin J Am Soc NephrolNo abstract available -- Editorial
-
06:00The Role of Anti-B Cell Activating Factor Therapy for Treating Lupus Nephritis - Clin J Am Soc NephrolNo abstract available -- Editorial
-
06:00Can We Turn the Symptom Curve?: Symptom Trajectories and Outcomes among Patients with CKD - Clin J Am Soc NephrolNo abstract available -- Editorial
-
06:00
Background and objectives Late stages of CKD are characterized by significant symptom burden. This study aimed to identify subgroups within the 5-year trajectories of symptom evolution in patients with CKD and to describe associated patient characteristics and outcomes. Design, setting, (...) -- Original Article: Chronic Kidney Disease
-
06:00
Background and objectives Chronic kidney disease (CKD) is a global public health issue associated with large economic burdens. CKD contributes to higher risks of cardiovascular complications, kidney failure, and mortality. The incidence and prevalence rates of kidney failure in Taiwan have (...) -- Original Article: Genetics
-
06:00
Background and objectives Membranous nephropathy is a rare autoimmune kidney disease whose increasing prevalence in industrialized countries pleads for the involvement of an environmental factor in the development of the disease. In addition, the predominance of men in membranous nephropathy, (...) -- Original Article: Glomerular and Tubulointerstitial Diseases
-
06:00Safety and Efficacy of Belimumab in Patients with Lupus Nephritis: Open-Label Extension of BLISS-LN Study - Clin J Am Soc NephrolBackground and objectives In the BLISS-LN study, belimumab improved kidney outcomes in adult patients with active lupus nephritis. This 28-week open-label extension of BLISS-LN assessed belimumab’s safety and efficacy. Design, setting, participants, & measurements Eligible patients completing (...) -- Original Article: Glomerular and Tubulointerstitial Diseases
-
06:00How the Routine Use of Patient-Reported Outcome Measures for Hemodialysis Care Influences Patient-Clinician Communication: A Mixed-Methods Study - Clin J Am Soc NephrolBackground and objectives Patient-reported outcome measures invite patients to self-report aspects of their quality of life and have been reported to enhance communication with clinicians. We aimed to examine how routine use of patient-reported outcome measures in in-center hemodialysis units (...) -- Original Article: Maintenance Dialysis
-
06:00Longitudinal Evaluation of Donor-Derived Cellfree DNA in Pediatric Kidney Transplantation - Clin J Am Soc NephrolBackground and objectives Donor-derived cellfree DNA (cfDNA) is a less-invasive marker of allograft injury compared with kidney biopsy. However, donor-derived cfDNA has not yet been extensively tested in children, where the test may have different characteristics. Design, setting, participants, (...) -- Original Article: Transplantation
-
06:00A Qualitative Content Analysis of Comments on Press Articles on Deemed Consent for Organ Donation in Canada - Clin J Am Soc NephrolBackground and objectives In 2019, two Canadian provinces became the first jurisdictions in North America to pass deemed consent legislation to increase deceased organ donation and transplantation rates. We sought to explore the perspectives of the deemed consent legislation for organ donation (...) -- Original Article: Transplantation
-
06:00Effects of Dapagliflozin in People without Diabetes and with Microalbuminuria - Clin J Am Soc NephrolNo abstract available -- Research Letter
-
06:00Processes of Care in Survivors of Acute Kidney Injury followed in Specialized Postdischarge Clinics - Clin J Am Soc NephrolNo abstract available -- Research Letter
-
06:00Correction: Physiology of the Aging Kidney: We Know Where We Are Going, but We Don’t Know How… Clin J Am Soc NephrolNo abstract available -- Erratum
-
06:00
AKI is commonly encountered in patients with decompensated cirrhosis, and it is associated with unfavorable outcomes. Among factors specific to cirrhosis, hepatorenal syndrome type 1, also referred to as hepatorenal syndrome-AKI, is the most salient and unique etiology. Patients with cirrhosis (...) -- Critical Care Nephrology and Acute Kidney Injury
-
06:00
No abstract available -- Kidney Case Conference: How I Treat
-
06:00Reducing the Risks of Home Dialysis Innovation and Uptake: The Case for Human-Centered Product Design - Clin J Am Soc NephrolNo abstract available -- Perspective
-
06:00
No abstract available -- Perspective
-
06:00
No abstract available -- Perspective
-
06:00
Digenic Alport syndrome refers to the inheritance of pathogenic variants in COL4A5 plus COL4A3 or COL4A4 or in COL4A3 plus COL4A4. Where digenic Alport syndrome includes a pathogenic COL4A5 variant, the consequences depend on the sex of the affected individual, COL4A5 variant “severity,” and the (...) -- Review
22 September
Clin J Am Soc Nephrol https://cjasn.asnjournals.org/
-
07:00Continuous Glucose Monitoring to Optimize Management of Diabetes in Patients with Advanced CKD - Clin J Am Soc NephrolTreatment of patients with diabetes and CKD includes optimizing glycemic control using lifestyle modifications and drugs that safely control glycemia and improve clinical kidney and cardiovascular disease outcomes. However, patients with advanced CKD, defined as (...) -- Review
13 September
Clin J Am Soc Nephrol https://cjasn.asnjournals.org/
-
07:00
KRT is considered for patients with severe AKI and associated complications. The exact indications for initiating KRT have been debated for decades. There is a general consensus that KRT should be considered in patients with AKI and medically refractory complications (“urgent indications”). (...) -- Critical Care Nephrology and Acute Kidney Injury
23 August
Clin J Am Soc Nephrol https://cjasn.asnjournals.org/
-
07:00
Acid-base disorders are common in the intensive care unit. By utilizing a systematic approach to their diagnosis, it is easy to identify both simple and mixed disturbances. These disorders are divided into four major categories: metabolic acidosis, metabolic alkalosis, respiratory acidosis, and (...) -- Critical Care Nephrology and Acute Kidney Injury
17 August
Clin J Am Soc Nephrol https://cjasn.asnjournals.org/
-
07:00
No abstract available -- Kidney Case Conference: How I Treat
7 July
Clin J Am Soc Nephrol https://cjasn.asnjournals.org/
- 19:00
- 19:00
- 19:00
- 19:00
- 19:00
-
19:00Urine Output Monitoring for the Diagnosis of Early-Onset Acute Kidney Injury in Very Preterm Infants - Clin J Am Soc NephrolBackground and objectives The current threshold used for oliguria in the definition of neonatal AKI has been empirically defined as 1 ml/kg per hour. Urine output criteria are generally poorly documented, resulting in uncertainty in the most accurate threshold to identify AKI in very preterm (...)
-
19:00
Background and objectives Coronavirus disease 2019 (COVID-19) disrupted medical care across health care settings for older patients with advanced CKD. Understanding how shared decision making for kidney treatment decisions was influenced by the uncertainty of an evolving pandemic can provide (...)
-
19:00Association of Mitochondrial DNA Copy Number with Risk of Progression of Kidney Disease - Clin J Am Soc NephrolBackground and objectives Mitochondrial DNA copy number is a biomarker of mitochondrial function, which has been hypothesized to contribute to pathogenesis of CKD through podocyte injury, tubular epithelial cell damage, and endothelial dysfunction. The prospective association of mitochondrial (...)
-
19:00Health Disparities in Autosomal Dominant Polycystic Kidney Disease (ADPKD) in the United States - Clin J Am Soc NephrolBackground and objectives Autosomal dominant polycystic kidney disease (ADPKD) occurs at conception and is often diagnosed decades prior to kidney failure. Nephrology care and transplantation access should be independent of race and ethnicity. However, institutional racism and barriers to (...)
-
19:00Glomerular Exostosin as a Subtype and Activity Marker of Class 5 Lupus Nephritis - Clin J Am Soc NephrolBackground and objectives There have been only several studies on the correlation between glomerular exostosin expression and membranous lupus nephritis. In this study, we validate the previous findings in Chinese patients with class 5 lupus nephritis. Design, setting, participants, & (...)
-
19:00Association of Histologic Parameters with Outcome in C3 Glomerulopathy and Idiopathic Immunoglobulin-Associated Membranoproliferative Glomerulonephritis - Clin J Am Soc NephrolBackground and objectives C3 glomerulopathy and idiopathic Ig-associated membranoproliferative GN are kidney diseases characterized by abnormal glomerular complement C3 deposition. These conditions are heterogeneous in outcome, but approximately 50% of patients develop kidney failure within 10 (...)
-
19:00Immune Responses after a Third Dose of mRNA Vaccine Differ in Virus-Naive versus SARS-CoV-2- Recovered Dialysis Patients - Clin J Am Soc NephrolBackground and objectives After two doses of mRNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), patients on dialysis show a defective humoral response, but a third dose could increase anti–SARS-CoV-2 spike IgG titers. Responses could be different in virus-naive (...)
-
19:00Automated Determination of Left Ventricular Function Using Electrocardiogram Data in Patients on Maintenance Hemodialysis - Clin J Am Soc NephrolBackground and objectives Left ventricular ejection fraction is disrupted in patients on maintenance hemodialysis and can be estimated using deep learning models on electrocardiograms. Smaller sample sizes within this population may be mitigated using transfer learning. Design, setting, (...)
-
19:00Machine Learning-Derived Integer-Based Score and Prediction of Tertiary Hyperparathyroidism among Kidney Transplant Recipients: An Integer-Based Score to Predict Tertiary Hyperparathyroidism - Clin J Am Soc NephrolBackground and objectives Tertiary hyperparathyroidism in kidney allograft recipients is associated with bone loss, allograft dysfunction, and cardiovascular mortality. Accurate pretransplant risk prediction of tertiary hyperparathyroidism may support individualized treatment decisions. We (...)
- 19:00
-
19:00Low-Flow Acute Kidney Injury: The Pathophysiology of Prerenal Azotemia, Abdominal Compartment Syndrome, and Obstructive Uropathy - Clin J Am Soc NephrolAKI is a syndrome, not a disease. It results from many different primary and/or secondary etiologies and is often multifactorial, especially in the hospitalized patient. This review discusses the pathophysiology of three etiologies that cause AKI, those being kidney hypoperfusion, abdominal (...)
-
19:00
Sepsis-associated AKI is a life-threatening complication that is associated with high morbidity and mortality in patients who are critically ill. Although it is clear early supportive interventions in sepsis reduce mortality, it is less clear that they prevent or ameliorate sepsis-associated (...)
- 19:00
- 19:00
- 19:00
- 19:00
-
19:00
Contemporary nephrology practice is heavily weighted toward in-center hemodialysis, reflective of decisions on infrastructure and personnel in response to decades of policy. The Advancing American Kidney Health initiative seeks to transform care for patients and providers. Under the (...)
-
19:00Moving from Evidence to Implementation of Breakthrough Therapies for Diabetic Kidney Disease - Clin J Am Soc NephrolDiabetic kidney disease is the most frequent cause of kidney failure, accounting for half of all cases worldwide. Moreover, deaths from diabetic kidney disease increased 106% between 1990 and 2013, with most attributed to cardiovascular disease. Recommended screening and monitoring for diabetic (...)
7 June
Clin J Am Soc Nephrol https://cjasn.asnjournals.org/
- 19:00
- 19:00
- 19:00
- 19:00
- 19:00
- 19:00
- 19:00
-
19:00Diagnostic Performance of Fractional Excretion of Sodium for the Differential Diagnosis of Acute Kidney Injury: A Systematic Review and Meta-Analysis - Clin J Am Soc NephrolBackground and objectives AKI is classified as prerenal, intrinsic, and postrenal. Prerenal AKI and intrinsic AKI represent the most common causes for AKI in hospitalized patients. This study aimed to examine the accuracy of the fractional excretion of sodium for distinguishing intrinsic from (...)
-
19:00Apolipoprotein L1 High-Risk Genotypes and Albuminuria in Sub-Saharan African Populations - Clin J Am Soc NephrolBackground and objectives Recessive inheritance of African-specific APOL1 kidney risk variants is associated with higher risk of nondiabetic kidney disease, progression to kidney failure, and early-onset albuminuria that precedes eGFR decline. The effect of APOL1 risk variants on kidney (...)
-
19:00PCSK9 and Cardiovascular Disease in Individuals with Moderately Decreased Kidney Function - Clin J Am Soc NephrolBackground and objectives Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of lipid homeostasis. Studies investigating the association between PCSK9 and cardiovascular disease in large cohorts of patients with CKD are limited. Design, setting, participants, & (...)
-
19:00Evaluation of Conflicts of Interest among Participants of the Japanese Nephrology Clinical Practice Guideline - Clin J Am Soc NephrolBackground and objectives Rigorous and transparent management strategies for conflicts of interest and clinical practice guidelines with the best available evidence are necessary for the development of nephrology guidelines. However, there was no study assessing financial and nonfinancial (...)
-
19:00Total Kidney Volume Measurements in ADPKD by 3D and Ellipsoid Ultrasound in Comparison with Magnetic Resonance Imaging - Clin J Am Soc NephrolBackground and objectives Total kidney volume is a validated prognostic biomarker for autosomal dominant polycystic kidney disease. Total kidney volume by magnetic resonance imaging (MRI) and manual segmentation is considered the "reference standard," but it is time consuming and not readily (...)
-
19:00Fracture Risk of Sodium-Glucose Cotransporter-2 Inhibitors in Chronic Kidney Disease - Clin J Am Soc NephrolBackground and objectives Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been associated with a higher risk of skeletal fractures in some randomized, placebo-controlled trials. Secondary hyperparathyroidism and increased bone turnover (also common in CKD) may contribute to the observed (...)
-
19:00Severity of COVID-19 after Vaccination among Hemodialysis Patients: An Observational Cohort Study - Clin J Am Soc NephrolBackground and objectives Patients receiving hemodialysis are at high risk from coronavirus disease 2019 (COVID-19) and demonstrate impaired immune responses to vaccines. There have been several descriptions of their immunologic responses to severe acute respiratory syndrome coronavirus 2 (...)
-
19:00Medicare Bundled Payment Policy on Anemia Care, Major Adverse Cardiovascular Events, and Mortality among Adults Undergoing Hemodialysis - Clin J Am Soc NephrolBackground and objectives In 2011, the Centers for Medicare & Medicaid Services implemented bundling of all services for patients receiving dialysis, including erythropoietin-stimulating agents use, and the Food and Drug Administration recommended conservative erythropoietin-stimulating (...)
-
19:00Variation in Peritoneal Dialysis Time on Therapy by Country: Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study - Clin J Am Soc NephrolBackground and objectives Quantifying contemporary peritoneal dialysis time on therapy is important for patients and providers. We describe time on peritoneal dialysis in the context of outcomes of hemodialysis transfer, death, and kidney transplantation on the basis of the multinational, (...)
- 19:00
- 19:00
- 19:00
-
19:00
The definition of sepsis has evolved significantly over the past three decades. Today, sepsis is defined as a dysregulated host immune response to microbial invasion leading to end organ dysfunction. Septic shock is characterized by hypotension requiring vasopressors after adequate fluid (...)
-
19:00
Mechanical life support therapies exist in many forms to temporarily replace the function of vital organs. Generally speaking, these tools are supportive therapy to allow for organ recovery but, at times, require transition to long-term mechanical support. This review will examine nonrenal (...)
- 19:00
- 19:00
- 19:00
-
19:00Cannabinoids for Symptom Management in Patients with Kidney Failure: A Narrative Review - Clin J Am Soc NephrolPeople with kidney failure can experience a range of symptoms that lead to suffering and poor quality of life. Available therapies are limited, and evidence for new treatment options is sparse, often resulting in incomplete relief of symptoms. There is growing interest in the potential for (...)
-
19:00
Novel immunotherapy drugs have changed the landscape of cancer medicine. Immune checkpoint inhibitors and chimeric antigen receptor T cells are being used and investigated in almost all types of cancers. Immune-related adverse events have been associated with immunotherapies. AKI has been the (...)
6 May
Clin J Am Soc Nephrol https://cjasn.asnjournals.org/
- 19:00
- 19:00
- 19:00
- 19:00
-
19:00Association of Phosphate-Containing versus Phosphate-Free Solutions on Ventilator Days in Patients Requiring Continuous Kidney Replacement Therapy - Clin J Am Soc NephrolBackground and objectives Hypophosphatemia is commonly observed in patients receiving continuous KRT. Patients who develop hypophosphatemia may be at risk of respiratory and neuromuscular dysfunction and therefore subject to prolongation of ventilator support. We evaluated the association of (...)
-
19:00Dapagliflozin and Kidney Outcomes in Hospitalized Patients with COVID-19 Infection: An Analysis of the DARE-19 Randomized Controlled Trial - Clin J Am Soc NephrolBackground and objectives Patients who were hospitalized with coronavirus disease 2019 (COVID-19) infection are at high risk of AKI and KRT, especially in the presence of CKD. The Dapagliflozin in Respiratory Failure in Patients with COVID-19 (DARE-19) trial showed that in patients (...)
-
19:00
Background and objectives Despite the dramatic increase in the provision of virtual nephrology care, only anecdotal reports of outcomes without comparators to usual care exist in the literature. This study aimed to provide objective determination of clinical noninferiority of hybrid (...)
-
19:00SGLT2 Inhibition and Uric Acid Excretion in Patients with Type 2 Diabetes and Normal Kidney Function - Clin J Am Soc NephrolBackground and objectives Sodium-glucose transporter 2 (SGLT2) inhibitor–induced uric acid lowering may contribute to kidney-protective effects of the drug class in people with type 2 diabetes. This study investigates mechanisms of plasma uric acid lowering by SGLT2 inhibitors in people with (...)
-
19:00
Background and objectives Glomerular hematuria has varied causes but can have a genetic basis, including Alport syndrome and IgA nephropathy. Design, setting, participants, & measurements We used summary statistics to identify genetic variants associated with hematuria in White British UK (...)
-
19:00
Background and objectives The APOL1 risk variants (G1 and G2) are associated with kidney disease among Black adults, but the clinical presentation is heterogeneous. In mouse models and cell systems, increased gene expression of G1 and G2 confers cytotoxicity. How APOL1 risk variants relate to (...)
-
19:00Apixaban versus Warfarin for Treatment of Venous Thromboembolism in Patients Receiving Long-Term Dialysis - Clin J Am Soc NephrolBackground and objectives The association of apixaban compared with warfarin for the treatment of venous thromboembolism in patients receiving maintenance dialysis is not well studied. Design, setting, participants, & measurements We conducted a retrospective cohort study of Medicare (...)
- 19:00
-
19:00The Intensivist's Perspective of Shock, Volume Management, and Hemodynamic Monitoring - Clin J Am Soc NephrolOne of the primary reasons for intensive care admission is shock. Identifying the underlying cause of shock (hypovolemic, distributive, cardiogenic, and obstructive) may lead to entirely different clinical pathways for management. Among patients with hypovolemic and distributive shock, fluid (...)
-
19:00Overview of Diagnostic Criteria and Epidemiology of Acute Kidney Injury and Acute Kidney Disease in the Critically Ill Patient - Clin J Am Soc NephrolSince the description ischuria renalis by William Heberden (1), AKI has remained a prominent complication of critical illness. Beyond KRT, treatment has been limited by the capacity to phenotype this condition. Here, we chronicle the evolution of attempts to classify AKI, including the adoption (...)
- 19:00
- 19:00
- 19:00
- 19:00
-
19:00Mass Transport in High-Flux Hemodialysis: Application of Engineering Principles to Clinical Prescription - Clin J Am Soc NephrolAn understanding of the processes underlying mass transfer is paramount for the attainment of adequate solute removal in the dialytic treatment of patients with kidney failure. In this review, engineering principles are applied to characterize the physical mechanisms behind the two major modes (...)
-
19:00
Fluid overload is a common complication in patients with CKD, particularly patients with kidney failure, a population with a very high risk for pulmonary edema. Lung ultrasound is now a well-validated technique that allows for reliable estimates of lung water in clinical practice. Several (...)
7 April
Clin J Am Soc Nephrol https://cjasn.asnjournals.org/
- 19:00
- 19:00
- 19:00
- 19:00
- 19:00
-
19:00Patient-Reported Symptoms and Subsequent Risk of Myocardial Infarction in Chronic Kidney Disease - Clin J Am Soc NephrolBackground and objectives Although patient-reported symptoms often precede acute presentations of cardiovascular disease, patients with nondialysis-requiring CKD are less likely to have typical symptoms of atherosclerotic disease when presenting with acute myocardial infarction. However, the (...)
-
19:00Trajectories of Uremic Symptom Severity and Kidney Function in Patients with Chronic Kidney Disease - Clin J Am Soc NephrolBackground and objectives Uremic symptoms, including fatigue, anorexia, pruritus, nausea, paresthesia, and pain, are attributed to the accumulation of organic waste products normally cleared by the kidneys, but whether kidney function is the primary driver of changes in symptom severity over (...)
-
19:00Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial - Clin J Am Soc NephrolBackground and objectives The vasopressin V2 receptor antagonist tolvaptan is the only drug that has been proven to be nephroprotective in autosomal dominant polycystic kidney disease (ADPKD). Tolvaptan also causes polyuria, limiting tolerability. We hypothesized that cotreatment with (...)
-
19:00Chronic Kidney Disease from Polyvinylpyrrolidone Deposition in Persons with Intravenous Drug Use - Clin J Am Soc NephrolBackground and objectives Persons with intravenous drug use have a higher risk of developing CKD compared with the general population. In Norway, deposits of polyvinylpyrrolidone have been observed in kidney biopsies taken from persons with opioid addiction and intravenous drug use since 2009. (...)
-
19:00Kidney Histopathologic Spectrum and Clinical Indicators Associated with MGRS - Clin J Am Soc NephrolBackground and objectives Patients with monoclonal gammopathy and concomitant kidney diseases are frequently found in clinical practice. Some of them are diagnosed with monoclonal gammopathy of renal significance (MGRS) due to the presence of monoclonal Ig–related kidney injuries. This study (...)
-
19:00Multifaceted Intervention to Increase the Use of Home Dialysis: A Cluster Randomized Controlled Trial - Clin J Am Soc NephrolBackground and objectives Home dialysis therapies (peritoneal and home hemodialysis) are less expensive and provide similar outcomes to in-center hemodialysis, but they are underutilized in most health systems. Given this, we designed a multifaceted intervention to increase the use of home (...)
-
19:00Association of Serum Phosphate with Efficacy of Statin Therapy in Hemodialysis Patients - Clin J Am Soc NephrolBackground and objectives Statins are less efficacious in reducing cardiovascular disease risk in patients on dialysis than in the general population. Recent experimental data showed that phosphate excess promotes cellular de novo cholesterol synthesis through 3-hydroxy-3-methylglutaryl CoA (...)
-
19:00The Knowledge Assessment of Renal Transplantation (KART) 2.0: Development and Validation of CKD and Transplant Knowledge Scales - Clin J Am Soc NephrolBackground and objectives Many individuals with kidney disease, particularly those belonging to racial and ethnic minority groups and whose primary language is not English, lack knowledge related to kidney disease symptoms, physiologic functions of the kidney, and benefits and risks of kidney (...)
- 19:00
- 19:00
- 19:00
-
19:00Management of Respiratory Failure: Ventilator Management 101 and Noninvasive Ventilation - Clin J Am Soc NephrolMechanical ventilation is a lifesaving therapy for critically ill patients with respiratory failure, but like all treatments, it has the potential to cause harm if not administered appropriately. This review aims to give an overview of the basic principles of invasive and noninvasive mechanical (...)
- 19:00
- 19:00
- 19:00
- 19:00
-
19:00Molecular Signatures of Diabetic Kidney Disease Hiding in a Patient with Hypertension-Related Kidney Disease: A Clinical Pathologic Molecular Correlation - Clin J Am Soc NephrolThe Kidney Precision Medicine Project (KPMP) seeks to establish a molecular atlas of the kidney in health and disease and improve our understanding of the molecular drivers of CKD and AKI. Herein, we describe the case of a 66-year-old woman with CKD who underwent a protocol KPMP kidney biopsy. (...)
-
19:00Extracorporeal Treatment for Methotrexate Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup - Clin J Am Soc NephrolMethotrexate is used in the treatment of many malignancies, rheumatological diseases, and inflammatory bowel disease. Toxicity from use is associated with severe morbidity and mortality. Rescue treatments include intravenous hydration, folinic acid, and, in some centers, glucarpidase. We (...)
7 March
Clin J Am Soc Nephrol https://cjasn.asnjournals.org/
- 19:00
- 19:00
- 19:00
- 19:00
-
19:00Utilization of Palliative Care for Patients with COVID-19 and Acute Kidney Injury during a COVID-19 Surge - Clin J Am Soc NephrolBackground and objectives AKI is a common complication of coronavirus disease 2019 (COVID-19) and is associated with high mortality. Palliative care, a specialty that supports patients with serious illness, is valuable for these patients but is historically underutilized in AKI. The objectives (...)
-
19:00Comparison of Aptamer-Based and Antibody-Based Assays for Protein Quantification in Chronic Kidney Disease - Clin J Am Soc NephrolBackground and objectives Novel aptamer-based technologies can identify >7000 analytes per sample, offering a high-throughput alternative to traditional immunoassays in biomarker discovery. However, the specificity for distinct proteins has not been thoroughly studied in the context of CKD. (...)
-
19:00Potential Effects of Elimination of the Black Race Coefficient in eGFR Calculations in the CREDENCE Trial - Clin J Am Soc NephrolBackground and objectives The effect of including race in the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation on screening, recruitment, and outcomes of clinical trials is unclear. Design, setting, participants, & measurements The inclusion and outcomes of (...)
-
19:00Volume Progression and Imaging Classification of Polycystic Liver in Early Autosomal Dominant Polycystic Kidney Disease - Clin J Am Soc NephrolBackground and objectives The progression of polycystic liver disease is not well understood. The purpose of the study is to evaluate the associations of polycystic liver progression with other disease progression variables and classify liver progression on the basis of patient's age, (...)
-
19:00The Cost-Effectiveness of Belimumab and Voclosporin for Patients with Lupus Nephritis in the United States - Clin J Am Soc NephrolBackground and objectives Despite existing therapies, people with lupus nephritis progress to kidney failure and have reduced life expectancy. Belimumab and voclosporin are two new disease-modifying therapies recently approved for the treatment of lupus nephritis. Design, setting, (...)
-
19:00
Background and objectives Dialysis patients have a high mortality risk after coronavirus disease 2019 (COVID-19) and an altered immunologic response to vaccines, but vaccine clinical effectiveness remains unknown in this population. Design, setting, participants, & measurements Using (...)
-
19:00Seroresponse to SARS-CoV-2 Vaccines among Maintenance Dialysis Patients over 6 Months - Clin J Am Soc NephrolBackground and objectives Although most patients receiving maintenance dialysis exhibit initial seroresponse to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, concerns exist regarding the durability of this antibody response. This study evaluated seroresponse over (...)
-
19:00Inflammatory Cells in Nephrectomy Tissue from Patients without and with a History of Urinary Stone Disease - Clin J Am Soc NephrolBackground and objectives Urinary stone disease has been associated with inflammation, but the specific cell interactions that mediate events remain poorly defined. This study compared calcification and inflammatory cell patterns in kidney tissue from radical nephrectomy specimens of patients (...)
- 19:00
- 19:00
-
19:00Catheter-Associated Bloodstream Infections among Patients on Hemodialysis: Progress before and during the COVID-19 Pandemic - Clin J Am Soc NephrolMeasures implemented to prevent transmission of severe acute respiratory syndrome coronavirus 2 in outpatient dialysis facilities may also help to prevent catheter-associated bloodstream infections in patients receiving hemodialysis. We used United States Renal Data System data to examine rates (...)
-
19:00
Cancer is an important outcome after kidney transplantation because it is the second leading cause of death in most Western countries. The excess risk of cancer after transplantation is approximately two to three times higher than the age- and sex-matched general population, driven largely by (...)
-
19:00
Patients who receive a kidney transplant commonly experience failure of their allograft. Transplant failure often comes with complex management decisions, such as when and how to wean immunosuppression and start the transition to a second transplant or to dialysis. These decisions are made in (...)
- 19:00
- 19:00
-
19:00
An exploration of the normal limits of physiologic responses and how these responses are lost when the kidney is injured rarely occurs in clinical practice. However, the differences between "resting" and "stressed" responses identify an adaptive reactiveness that is diminished before baseline (...)
-
19:00Can Novel Potassium Binders Liberate People with Chronic Kidney Disease from the Low-Potassium Diet?: A Cautionary Tale - Clin J Am Soc NephrolThe advent of new potassium binders provides an important breakthrough in the chronic management of hyperkalemia for people with CKD. In addition to the direct benefits of managing hyperkalemia, many researchers and clinicians view these new medications as a possible means to safely transition (...)
7 February
Clin J Am Soc Nephrol https://cjasn.asnjournals.org/
- 19:00
- 19:00
- 19:00
- 19:00
- 19:00
-
19:00In-Hospital and 1-Year Mortality Trends in a National Cohort of US Veterans with Acute Kidney Injury - Clin J Am Soc NephrolBackground and objectives AKI, a frequent complication among hospitalized patients, confers excess short- and long-term mortality. We sought to determine trends in in-hospital and 1-year mortality associated with AKI as defined by Kidney Disease Improving Global Outcomes consensus criteria. (...)
-
19:00Controlled Study of Decision-Making Algorithms for Kidney Replacement Therapy Initiation in Acute Kidney Injury - Clin J Am Soc NephrolBackground and objectives AKI requiring KRT is associated with high mortality and utilization. We evaluated the use of an AKI Standardized Clinical Assessment and Management Plan (SCAMP) on patient outcomes, including mortality, hospital length of stay, and intensive care unit length of stay. (...)
-
19:00Health-Related Quality-of-Life Trajectories over Time in Older Men and Women with Advanced Chronic Kidney Disease - Clin J Am Soc NephrolBackground and objectives The effect of sex on longitudinal health-related quality of life remains unknown in CKD. Here we assess differences in the sex-specific evolution of health-related quality of life in older men and women with advanced CKD. Design, setting, participants, & (...)
-
19:00Patient and Caregiver Experiences and Attitudes about Their Involvement in Research in Chronic Kidney Disease - Clin J Am Soc NephrolBackground and objectives Although patient and caregiver involvement in research is widely advocated to improve the relevance and uptake of study findings, barriers and uncertainties in achieving this goal remain. This study aimed to describe patient and caregiver experiences and perspectives (...)
-
19:00Assessment of Proximal Tubular Function by Tubular Maximum Phosphate Reabsorption Capacity in Heart Failure - Clin J Am Soc NephrolBackground and objectives The estimated glomerular filtration rate (eGFR) is a crucial parameter in heart failure. Much less is known about the importance of tubular function. We addressed the effect of tubular maximum phosphate reabsorption capacity (TmP/GFR), a parameter of proximal tubular (...)
-
19:00Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD: A Randomized Controlled Trial - Clin J Am Soc NephrolBackground and objectives Clinical manifestations of autosomal dominant polycystic kidney disease (ADPKD), including evidence of vascular dysfunction, can begin in childhood. Curcumin is a polyphenol found in turmeric that reduces vascular dysfunction in rodent models and humans without ADPKD. (...)
-
19:00Association between TNF Receptors and KIM-1 with Kidney Outcomes in Early-Stage Diabetic Kidney Disease - Clin J Am Soc NephrolBackground and objectives Clinical trials in nephrology are enriched for patients with micro- or macroalbuminuria to enroll patients at risk of kidney failure. However, patients with normoalbuminuria can also progress to kidney failure. TNF receptor-1, TNF receptor-2, and kidney injury (...)
-
19:00Automatic Evaluation of Histological Prognostic Factors Using Two Consecutive Convolutional Neural Networks on Kidney Samples - Clin J Am Soc NephrolBackground and objectives The prognosis of patients undergoing kidney tumor resection or kidney donation is linked to many histologic criteria. These criteria notably include glomerular density, glomerular volume, vascular luminal stenosis, and severity of interstitial fibrosis/tubular (...)
-
19:00Use and Outcomes of Induction Therapy in Well-Matched Kidney Transplant Recipients - Clin J Am Soc NephrolBackground and objectives The optimal induction treatment in low–immune risk kidney transplant recipients is uncertain. We therefore investigated the use and outcomes of induction immunosuppression in a low-risk cohort of patients who were well matched with their donor at HLA-A, -B, -DR, -DQB1 (...)
- 19:00
- 19:00
-
19:00
Infections remain a common complication of solid-organ transplantation. Most infections in the first month after transplant are typically health care–associated infections, whereas late infections, beyond 6–12 months, are community-acquired infections. Opportunistic infections most frequently (...)
-
19:00
Pediatric kidney transplant recipients are distinguished from adult recipients by the need for many decades of graft function, the potential effect of CKD on neurodevelopment, and the changing immune environment of a developing human. The entire life of an individual who receives a transplant (...)
- 19:00
- 19:00
- 19:00
-
19:00Use of Race in Kidney Research and Medicine: Concepts, Principles, and Practice - Clin J Am Soc NephrolBlack Americans and other racially and ethnically minoritized individuals are disproportionately burdened by higher morbidity and mortality from kidney disease when compared with their White peers. Yet, kidney researchers and clinicians have struggled to fully explain or rectify causes of these (...)
-
19:00
Kidney homeostasis is highly dependent upon the correct functioning of myeloid cells. These cells form a distributed surveillance network throughout the kidney, where they play an integral role in the response to organ threat. Dysregulation of resident proinflammatory and profibrotic (...)