20 March

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  A Special Thanks to the Reviewers of Diabetes Diabetes
  Diabetes calls on thousands of scientific and medical experts each year to review manuscript submissions. The editors of Diabetes sincerely appreciate the efforts of all of our reviewers who volunteer their time and expertise to provide valuable feedback to ensure the consistently high quality (...)
• 01:00
  Issues and Events Diabetes
• 01:00
  In This Issue of Diabetes Diabetes
• 01:00
  Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings Diabetes
  The Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases workshop was a 1.5-day scientific conference at the National Institutes of Health (Bethesda, MD) that engaged clinical and basic science investigators interested in diseases of the pancreas. This report (...)

21 February

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  Issues and Events Diabetes
• 01:00
  In This Issue of Diabetes Diabetes
• 01:00
  Cardiac Microvascular Dysfunction and Cardiomyopathy in Diabetes: Is Ferroptosis a Therapeutic Target? Diabetes
  National Institutes of Health10.13039/100000002R01DK124344R01DK125330

20 January

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  Reduced Expression Level of Protein Phosphatase PPM1E Serves to Maintain Insulin Secretion in Type 2 Diabetes Diabetes
  Reversible phosphorylation is an important regulatory mechanism. Regulation of protein phosphorylation in ?-cells has been extensively investigated, but less is known about protein dephosphorylation. To understand the role of protein dephosphorylation in ?-cells and type 2 diabetes (T2D), we (...)
• 01:00
  Glucokinase Inhibition: A Novel Treatment for Diabetes? Diabetes
  Chronic hyperglycemia increases pancreatic ?-cell metabolic activity, contributing to glucotoxicity-induced ?-cell failure and loss of functional ?-cell mass, potentially in multiple forms of diabetes. In this perspective we discuss the novel paradoxical and counterintuitive concept of inhibiting (...)
• 01:00
  A Guide for Selection of Genetic Instruments in Mendelian Randomization Studies of Type 2 Diabetes and HbA 1c : Toward an Integrated Approach Diabetes
  In this study we examine the instrument selection strategies currently used throughout the type 2 diabetes and HbA1c Mendelian randomization (MR) literature. We then argue for a more integrated and thorough approach, providing a framework to do this in the context of HbA1c and diabetes. We (...)
• 01:00
  In This Issue of Diabetes Diabetes
• 01:00
  Issues and Events Diabetes
• 01:00
  Hyaluronan in Adipose Tissue, Metabolic Inflammation, and Diabetes: Innocent Bystander or Guilty Party? Diabetes
  Hyaluronic acid, or hyaluronan (HA), is a nonsulfated glucosaminoglycan that has long been recognized for its hydrophilic properties and is widely used as a dermal filler. Despite much attention given to the study of other extracellular matrix (ECM) components, in the field of ECM properties (...)

19 January

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  Loss of Hematopoietic Cell–Derived Oncostatin M Worsens Diet-Induced Dysmetabolism in Mice Diabetes
  Innate immune cells infiltrate growing adipose tissue and propagate inflammatory clues to metabolically distant tissues, thereby promoting glucose intolerance and insulin resistance. Cytokines of the IL-6 family and gp130 ligands are among such signals. The role played by oncostatin M (OSM) in (...)
• 01:00
  Association Between Obesity and Chronic Kidney Disease: Multivariable Mendelian Randomization Analysis and Observational Data From a Bariatric Surgery Cohort Diabetes
  Obesity is postulated to independently increase chronic kidney disease (CKD), even after adjusting for type 2 diabetes (T2D) and hypertension. Dysglycemia below T2D thresholds, frequently seen with obesity, also increases CKD risk. Whether obesity increases CKD independent of dysglycemia and (...)
• 01:00
  Inflammatory Cell Infiltration Into Islets Without PD-L1 Expression Is Associated With the Development of Immune Checkpoint Inhibitor–Related Type 1 Diabetes in Genetically Susceptible Patients Diabetes
  Immune checkpoint inhibitors (ICIs) could cause type 1 diabetes (T1D). However, the underlying mechanism remains unclear. We immunohistochemically analyzed pancreatic specimens from three individuals with ICI-related T1D, and their histopathological data were compared those from three patients (...)

11 January

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  Protein Markers of Diabetes Discovered in an African American Cohort Diabetes
  Proteomics has been used to study type 2 diabetes, but the majority of available data are from White participants. Here, we extend prior work by analyzing a large cohort of self-identified African Americans in the Jackson Heart Study (n = 1,313). We found 325 proteins associated with incident (...)

6 January

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  Fibroblast Growth Factor 6 Promotes Adipocyte Progenitor Cell Proliferation for Adipose Tissue Homeostasis Diabetes
  The de novo differentiation of hyperplastic adipocytes from adipocyte progenitor cells (APCs) is accompanied by a reduction in adipose tissue fibrosis and inflammation and improvement in insulin sensitivity in obesity and aging. However, the regulators of APC proliferation are poorly (...)

23 December

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  The Effect of Glucagon-Like Peptide 1 Receptor Blockade on Glucagon-Induced Stimulation of Insulin Secretion Diabetes
  Data from transgenic rodent models suggest that glucagon acts as an insulin secretagogue by signaling through the glucagon-like peptide 1 receptor (GLP-1R) present on ?-cells. However, its net contribution to physiologic insulin secretion in humans is unknown. To address this question, we (...)
• 01:00
  Mitochondrial Genome–Encoded Long Noncoding RNA and Mitochondrial Stability in Diabetic Retinopathy Diabetes
  Mitochondria experience genomic and functional instability in diabetes, and mitochondrial dysfunction has a critical role in the development of diabetic retinopathy. Diabetes also alters expressions of many long noncoding RNAs (LncRNAs), the RNAs with >200 nucleotides and no open reading frame. (...)

19 December

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  Cross-Ancestry DNA Methylation Marks of Insulin Resistance in Pregnancy: An Integrative Epigenome-Wide Association Study Diabetes
  Although there are some epigenome-wide association studies (EWAS) of insulin resistance, for most of them authors did not replicate their findings, and most are focused on populations of European ancestry, limiting the generalizability. In the Epigenetics in Pregnancy (EPIPREG; n = 294 (...)

16 December

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  Lower Hepatic Fat Is Associated With Improved Insulin Secretion in a High-Risk Prediabetes Subphenotype During Lifestyle Intervention Diabetes
  The objective of this work was to investigate whether impaired insulin secretion can be restored by lifestyle intervention in specific subphenotypes of prediabetes. We assigned 1,045 participants from the Prediabetes Lifestyle Intervention Study (PLIS) to six recently established prediabetes (...)

14 December

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  Roles of Pancreatic Islet Catecholamine Neurotransmitters in Glycemic Control and in Antipsychotic Drug–Induced Dysglycemia Diabetes
  Catecholamine neurotransmitters dopamine (DA) and norepinephrine (NE) are essential for a myriad of functions throughout the central nervous system, including metabolic regulation. These molecules are also present in the pancreas, and their study may shed light on the effects of peripheral (...)
• 01:00
  Issues and Events Diabetes
• 01:00
  In This Issue of Diabetes Diabetes
• 01:00
  Perilipin 1 Antibodies in Patients With Acquired Generalized Lipodystrophy Diabetes
  Wellcome Trust10.13039/100010269219417

12 December

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  High-Fat Diet–Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice Diabetes
  Dysregulated lipid droplet accumulation has been identified as one of the main contributors to liver steatosis during nonalcoholic fatty liver disease (NAFLD). However, the underlying molecular mechanisms for excessive lipid droplet formation in the liver remain largely unknown. In the current (...)

7 December

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  The Importance of Endogenously Secreted GLP-1 and GIP for Postprandial Glucose Tolerance and ?-Cell Function After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Surgery Diabetes
  Enhanced secretion of glucagon-like peptide 1 (GLP-1) seems to be essential for improved postprandial ?-cell function after Roux-en-Y gastric bypass (RYGB) but is less studied after sleeve gastrectomy (SG). Moreover, the role of the other major incretin hormone, glucose-dependent insulinotropic (...)

6 December

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  Rhamnose Displays an Anti-Obesity Effect Through Stimulation of Adipose Dopamine Receptors and Thermogenesis Diabetes
  The imbalance between energy intake and energy expenditure leads to the prevalence of obesity worldwide. A strategy to simultaneously limit energy intake and promote energy expenditure would be an important new obesity treatment. Here, we identified rhamnose as a nonnutritive sweetener to (...)

5 December

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  miR-210-3p Promotes Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Targeting SOCS1-Mediated NF-?B Pathway Diabetes
  Under the condition of chronic obesity, an increased level of free fatty acids along with low oxygen tension in the adipose tissue creates a pathophysiological adipose tissue microenvironment (ATenv), leading to the impairment of adipocyte function and insulin resistance. Here, we found the (...)

30 November

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  DPP-4 Inhibitor and Sulfonylurea Differentially Reverse Type 2 Diabetes–Induced Blood–Brain Barrier Leakage and Normalize Capillary Pericyte Coverage Diabetes
  Microvascular pathology in the brain is one of the suggested mechanisms underlying the increased incidence and progression of neurodegenerative diseases in people with type 2 diabetes (T2D). Although accumulating data suggest a neuroprotective effect of antidiabetics, the underlying mechanisms (...)
• 01:00
  Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling Diabetes
  Complex bidirectional cross talk between adipocytes and adipose tissue immune cells plays an important role in regulating adipose function, inflammation, and insulin responsiveness. Adipocytes secrete the pleiotropic cytokine IL-6 in response to both inflammatory and catabolic stimuli. Previous (...)
• 01:00
  Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo ?-Cell Imaging and Islet-Specific Therapies Diabetes
  Type 1 diabetes (T1D) is a disease in which autoimmune attacks are directed at the insulin-producing ?-cell in the pancreatic islet. Autoantigens on the ?-cell surface membrane are specific markers for molecular recognition and targets for engagement by autoreactive B lymphocytes, which produce (...)

29 November

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  Relationship Between a Sedentary Lifestyle and Adipose Insulin Resistance Diabetes
  Sedentary people have insulin resistance in their skeletal muscle, but whether this also occurs in fat cells was unknown. Insulin inhibition of hydrolysis of triglycerides (antilipolysis) and stimulation of triglyceride formation (lipogenesis) were investigated in subcutaneous fat cells from (...)
• 01:00
  GC-Globulin/Vitamin D–Binding Protein Is Required for Pancreatic ?-Cell Adaptation to Metabolic Stress Diabetes
  GC-globulin (GC), or vitamin D–binding protein, is a multifunctional protein involved in the transport of circulating vitamin 25(OH)D and fatty acids, as well as actin scavenging. In the pancreatic islets, the gene encoding GC, GC/Gc, is highly localized to glucagon-secreting ?-cells. Despite (...)

21 November

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  Erratum. Obese Skeletal Muscle–Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome. Diabetes 2022;71:2256–2271 Diabetes
  In the article cited above, affiliation 6 was incorrectly listed as “Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China” due to a composition error. The correct affiliation 6 is “Department of Endocrinology and Metabolism, Huashan Hospital, Fudan (...)

11 November

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  Isorhapontigenin Attenuates Cardiac Microvascular Injury in Diabetes via the Inhibition of Mitochondria-Associated Ferroptosis Through PRDX2-MFN2-ACSL4 Pathways Diabetes
  Ferroptosis is a newly identified form of regulated cell death that is driven by iron overload and uncontrolled lipid peroxidation, but the role of ferroptosis in cardiac microvascular dysfunction remains unclear. Isorhapontigenin (ISO) is an analog of resveratrol and possesses strong (...)
• 01:00
  Sex Differences in Adipose Tissue Distribution Determine Susceptibility to Neuroinflammation in Mice With Dietary Obesity Diabetes
  Preferential energy storage in subcutaneous adipose tissue (SAT) confers protection against obesity-induced pathophysiology in females. Females also exhibit distinct immunological responses, relative to males. These differences are often attributed to sex hormones, but reciprocal interactions (...)

8 November

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  Impaired Diurnal Pattern of Meal Tolerance and Insulin Sensitivity in Type 2 Diabetes: Implications for Therapy Diabetes
  To assess the diurnal patterns of postprandial glucose tolerance and insulin sensitivity, 19 subjects with type 2 diabetes (8 women; 60 ± 11 years; BMI 32 ± 5 kg/m2) and 19 anthropometrically matched subjects with no diabetes (ND; 11 women; 53 ± 12 years; BMI 29 ± 5 kg/m2) were studied during (...)
• 01:00
  N-end Rule–Mediated Proteasomal Degradation of ATGL Promotes Lipid Storage Diabetes
  Cellular lipid storage is regulated by the balance of lipogenesis and lipolysis. The rate-limiting triglyceride hydrolase ATGL (desnutrin/PNPLA2) is critical for lipolysis. The control of ATGL transcription, localization, and activation has been intensively studied, while regulation of the (...)
• 01:00
  An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes Diabetes
  Identifying the early islet cellular processes of autoimmune type 1 diabetes (T1D) in humans is challenging given the absence of symptoms during this period and the inaccessibility of the pancreas for sampling. In this article, we study temporal events in pancreatic islets in LEW.1WR1 rats, in (...)

3 November

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  Diametrical Effects of Glucose Levels on Microvascular Permeability of Peripheral Nerves in Patients With Type 2 Diabetes With and Without Diabetic Neuropathy Diabetes
  Clinical studies investigating the benefit of glucose control on the progression of diabetic neuropathy (DN) have come to controversial results in patients with type 2 diabetes (T2D). This study aimed to assess associations of HbA1c levels with parameters of nerve perfusion in patients with T2D (...)

2 November

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  Sustained Upregulation of Endothelial Nox4 Mediates Retinal Vascular Pathology in Type 1 Diabetes Diabetes
  NADPH oxidase 4 (Nox4) is a major source of reactive oxygen species (ROS) in retinal endothelial cells (ECs) and is upregulated under hyperglycemic and hypoxic conditions. However, the role of endothelial Nox4 upregulation in long-term retinal blood vessel damage in diabetic retinopathy (DR) (...)

1 November

Diabetes https://diabetes.diabetesjournals.org

• 01:00
  Prostaglandin PGE2 Receptor EP4 Regulates Microglial Phagocytosis and Increases Susceptibility to Diet-Induced Obesity Diabetes
  In rodents, susceptibility to diet-induced obesity requires microglial activation, but the molecular components of this pathway remain incompletely defined. Prostaglandin PGE2 levels increase in the mediobasal hypothalamus during high-fat-diet (HFD) feeding, and the PGE2 receptor EP4 regulates (...)

28 October

Diabetes https://diabetes.diabetesjournals.org

• 02:00
  Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes Diabetes
  Glucokinase (GK, gene symbol GCK) maturity-onset diabetes of the young (MODY) is caused by heterozygous inactivating mutations in GK and impaired glucose sensing. We investigated effects of dorzagliatin, a novel allosteric GK activator, on insulin secretion rates (ISRs) and ?-cell glucose (...)

24 October

Diabetes https://diabetes.diabetesjournals.org

• 02:00
  Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog Diabetes
  Endogenous insulin secretion is a key regulator of postprandial hepatic glucose metabolism, but this process is dysregulated in diabetes. Subcutaneous insulin delivery alters normal insulin distribution, causing relative hepatic insulin deficiency and peripheral hyperinsulinemia, a major risk (...)

18 October

Diabetes https://diabetes.diabetesjournals.org

• 02:00
  The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase Diabetes
  Despite significant progress in understanding the pathogenesis of type 2 diabetes (T2D), the condition remains difficult to manage. Hence, new therapeutic options targeting unique mechanisms of action are required. We have previously observed that elevated skeletal muscle succinyl (...)
• 02:00
  Endothelial-Specific Expression of CIDEC Improves High-Fat Diet–Induced Vascular and Metabolic Dysfunction Diabetes
  Cell death-inducing DNA fragmentation factor-?–like effector C (CIDEC), originally identified to be a lipid droplet–associated protein in adipocytes, positively associates with insulin sensitivity. Recently, we discovered that it is expressed abundantly in human endothelial cells and regulates (...)
• 02:00
  FGF13-Sensitive Alteration of Parkin Safeguards Mitochondrial Homeostasis in Endothelium of Diabetic Nephropathy Diabetes
  Studies of diabetic glomerular injury have raised the possibility of developing useful early biomarkers and therapeutic approaches for the treatment of type 2 diabetic nephropathy (T2DN). In this study, we found that FGF13 expression is induced in glomerular endothelial cells (GECs) during T2DN (...)

11 October

Diabetes https://diabetes.diabetesjournals.org

• 02:00
  Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats Diabetes
  Despite the successes of human genome-wide association studies, the causal genes underlying most metabolic traits remain unclear. We used outbred heterogeneous stock (HS) rats, coupled with expression data and mediation analysis, to identify quantitative trait loci (QTLs) and candidate gene (...)
• 02:00
  Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage Diabetes
  Excessive adiposity is the main cause of obesity and type two diabetes (T2D). Variants in human IMP2/IGF2BP2 gene are associated with increased risk of T2D. However, little is known about its role in adipogenesis and in insulin resistance. Here, we investigate the function of IMP2 during (...)

10 October

Diabetes https://diabetes.diabetesjournals.org

• 02:00
  Causal Associations Between Basal Metabolic Rate and COVID-19 Diabetes
  Many coronavirus disease 2019 (COVID-19) risk factors, including obesity and diabetes, are associated with an abnormal basal metabolic rate (BMR). We aimed to evaluate whether BMR could impact the susceptibility to or severity of COVID-19. We performed genetic correlation and Mendelian (...)

6 October

Diabetes https://diabetes.diabetesjournals.org

• 02:00
  Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4 + T Cells in Type 1 Diabetes Diabetes
  A recent discovery effort resulted in identification of novel splice variant and secretory granule antigens within the HLA class I peptidome of human islets and documentation of their recognition by CD8+ T cells from peripheral blood and human islets. In the current study, we applied a (...)

3 October

Diabetes https://diabetes.diabetesjournals.org

• 02:00
  Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid–Induced Rat ?-Cell Proliferation Diabetes
  The functional mass of insulin-secreting pancreatic ?-cells expands to maintain glucose homeostasis in the face of nutrient excess, in part via replication of existing ?-cells. Type 2 diabetes appears when these compensatory mechanisms fail. Nutrients including glucose and fatty acids are (...)

21 August

Diabetes https://diabetes.diabetesjournals.org

• 02:00
  The Yin and Yang of Modulating ?-Cell DNA Damage Response and Functional Mass Diabetes
  Pancreatic ?-cells secrete the hormone insulin, which is essential to maintain systemic glucose homeostasis. ?-Cell insufficiency due to impaired function, loss of identity, and increased cell death is central to the pathogenesis of diabetes. ?-Cells in adult life are postmitotic, with a limited (...)
• 02:00
  The ?-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events? Diabetes
  Recent reports have revived interest in the active role that ?-cells may play in type 1 diabetes pathogenesis at different stages of disease. In some studies, investigators suggested an initiating role and proposed that type 1 diabetes may be primarily a disease of ?-cells and only secondarily a (...)
• 02:00
  Going With the Flow: Pericyte-Regulated Islet Blood Flow Influences Glucose Homeostasis Diabetes
  Understanding how insulin secretion is regulated and how the ?-cells and islets become dysfunctional is critical to understanding and treating diabetes. The islets of Langerhans are highly vascularized, receiving ?10–20% of the pancreas blood flow (as measured by microbead accumulation) despite (...)
• 02:00
  The Mechanism for Adipose Endotrophin Production Diabetes
  The extracellular matrix (ECM) not only provides a structural support network for the assembly of individual cells into tissues but also affects growth, recruitment, differentiation, and function of the composing cells. In obesity, adipose tissue ECM undergoes remodeling, with dramatic changes (...)
• 02:00
  Metabolomic Markers in Early Pregnancy for Gestational Diabetes Mellitus Diabetes
  Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications, affecting 2–22% of all pregnancies depending on diagnostic criteria and study populations (1). GDM reflects an increased risk of type 2 diabetes (T2D) and cardiovascular diseases after the index pregnancy in (...)
• 02:00
  In This Issue of Diabetes Diabetes
• 02:00
  Issues and Events Diabetes
• 02:00
  A Special Thanks to Lyn Reynolds, Director of the ADA Editorial Office, as She Embarks on Her Retirement Diabetes
  For the past 26 years, the American Diabetes Association and its professional constituents have had the great pleasure of working with Lynda (“Lyn”) Reynolds, the director of the ADA Editorial Office. Lyn first joined ADA’s publishing team in 1997, when she was hired by editor in chief Charles M. (...)
• 02:00
  Erratum. Hepatic CPT1A Facilitates Liver–Adipose Cross Talk via Induction of FGF21 in Mice. Diabetes 2022;71:31–42 Diabetes
  In Fig. 3B of article cited above, for images of iWAT and eWAT, the labels “WT” and “LKO” were inadvertently transposed. LKO (Cpt1a knockout) should have been the label for the first set of images of adipose tissue, and WT (wild type) should have been the label for the second set of (...)
• 02:00
  Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes Diabetes
  Thymic presentation of self-antigens is critical for establishing a functional yet self-tolerant T-cell population. Hybrid peptides formed through transpeptidation within pancreatic ?-cell lysosomes have been proposed as a new class of autoantigens in type 1 diabetes (T1D). While the production (...)
• 02:00
  Infant Mesenchymal Stem Cell Insulin Action Is Associated With Maternal Plasma Free Fatty Acids, Independent of Obesity Status: The Healthy Start Study Diabetes
  Preclinical rodent and nonhuman primate models investigating maternal obesity have highlighted the importance of the intrauterine environment in the development of insulin resistance in offspring; however, it remains unclear if these findings can be translated to humans. To investigate possible (...)
• 02:00
  The Effect of Glucagon on Protein Catabolism During Insulin Deficiency: Exchange of Amino Acids Across Skeletal Muscle and the Splanchnic Bed Diabetes
  Transient insulin deprivation with concurrent hyperglucagonemia is a catabolic state that can occur in type 1 diabetes. To evaluate glucagon’s catabolic effect in the setting of its glucogenic effect, we measured the regional exchanges of amino acid metabolites (amino-metabolites) across muscle (...)
• 02:00
  Causal Graph Among Serum Lipids and Glycemic Traits: A Mendelian Randomization Study Diabetes
  We systematically investigated the bidirectional causality among HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TGs), fasting insulin (FI), and glycated hemoglobin A1c (HbA1c) based on genome-wide association summary statistics of Europeans (n = 1,320,016 for lipids, 151,013 (...)
• 02:00
  New Evidence of Central Nervous System Damage in Diabetes: Impairment of Fine Visual Discrimination Diabetes
  Diabetes can damage both the peripheral sensory organs, causing retinopathy, and the central visual system, leading to contrast sensitivity and impaired color vision in patients without retinopathy. Orientation discrimination is important for shape recognition by the visual system. Our (...)
• 02:00
  The p66 Shc Protein Mediates Insulin Resistance and Secretory Dysfunction in Pancreatic ?-Cells Under Lipotoxic Conditions Diabetes
  We evaluated the role of the p66Shc redox adaptor protein in pancreatic ?-cell insulin resistance that develops under lipotoxic conditions and with excess body fat. Prolonged exposure to palmitate in vitro or the presence of overweight/obesity augmented p66Shc expression levels and caused an (...)
• 02:00
  Diabetic Neuropathy in Hands: An Endemic Complication Waiting to Unfold? Diabetes
  In this cross-sectional study we aimed to quantify the somatosensory dysfunction in the hand in people with diabetes with distal symmetrical polyneuropathy (DSPN) in hands and explore early signs of nerve dysfunction in people with diabetes without DSPN in hands. The clinical diagnosis of DSPN (...)
• 02:00
  Targeting Pancreatic Islet NLRP3 Improves Islet Graft Revascularization Diabetes
  Hypoxia-induced islet cell death, caused by an insufficient revascularization of the grafts, is a major obstacle for successful pancreatic islet transplantation. Recently, it has been reported that the nucleotide-binding oligomerization domain–like receptor protein 3 (NLRP3) inflammasome is (...)
• 02:00
  Pericyte Control of Blood Flow in Intraocular Islet Grafts Impacts Glucose Homeostasis in Mice Diabetes
  The pancreatic islet depends on blood supply to efficiently sense plasma glucose levels and deliver insulin and glucagon into the circulation. Long believed to be passive conduits of nutrients and hormones, islet capillaries were recently found to be densely covered with contractile pericytes (...)
• 02:00
  Vertical Sleeve Gastrectomy Lowers SGLT2/ Slc5a2 Expression in the Mouse Kidney Diabetes
  Bariatric surgery improves glucose homeostasis, but the underlying mechanisms are not fully elucidated. Here, we show that the expression of sodium–glucose cotransporter 2 (SGLT2/Slc5a2) is reduced in the kidney of lean and obese mice following vertical sleeve gastrectomy (VSG). Indicating an (...)
• 02:00
  Acceptance of Murine Islet Allografts Without Immunosuppression in Inguinal Subcutaneous White Adipose Tissue Pretreated With bFGF Diabetes
  Prevention of immune rejection without immunosuppression is the ultimate goal of transplant immunobiology. One way to achieve this in cellular transplantation, such as with islet transplantation, is to create a favorable local environment at the transplant site. In the current study, we found (...)
• 02:00
  Roflumilast-Mediated Phosphodiesterase 4D Inhibition Reverses Diabetes-Associated Cardiac Dysfunction and Remodeling: Effects Beyond Glucose Lowering Diabetes
  Patients with type 2 diabetes have a substantial risk of developing cardiovascular disease. Phosphodiesterase 4 (PDE4) dysregulation is of pathophysiological importance in metabolic disorders. For determination of the role of PDE4 in diabetic cardiac dysfunction, mice fed with a high-fat diet (...)
• 02:00
  The Transcription Factor YY1 Is Essential for Normal DNA Repair and Cell Cycle in Human and Mouse ?-Cells Diabetes
  Identifying the mechanisms behind the ?-cell adaptation to failure is important to develop strategies to manage type 2 diabetes (T2D). Using db/db mice at early stages of the disease process, we took advantage of unbiased RNA sequencing to identify genes/pathways regulated by insulin resistance (...)
• 02:00
  Plasma apoM Levels and Progression to Kidney Dysfunction in Patients With Type 1 Diabetes Diabetes
  Apolipoprotein M (apoM), primarily carried by HDL, has been associated with several conditions, including cardiovascular disease and diabetic nephropathy. This study proposes to examine whether plasma apoM levels are associated with the development of diabetic kidney disease, assessed as (...)
• 02:00
  Immunogenicity and Safety of SARS-CoV-2 mRNA Vaccines in a Cohort of Patients With Type 1 Diabetes Diabetes
  Patients with type 1 diabetes (T1D) may develop severe outcomes during coronavirus disease 2019 (COVID-19), but their ability to generate an immune response against the SARS-CoV-2 mRNA vaccines remains to be established. We evaluated the safety, immunogenicity, and glycometabolic effects of the (...)
• 02:00
  Predictive Metabolomic Markers in Early to Mid-pregnancy for Gestational Diabetes Mellitus: A Prospective Test and Validation Study Diabetes
  Gestational diabetes mellitus (GDM) predisposes pregnant individuals to perinatal complications and long-term diabetes and cardiovascular diseases. We developed and validated metabolomic markers for GDM in a prospective test-validation study. In a case-control sample within the PETALS cohort (...)
• 02:00
  MicroRNA-29 Ameliorates Fibro-Inflammation and Insulin Resistance in HIF1?-Deficient Obese Adipose Tissue by Inhibiting Endotrophin Generation Diabetes
  Dysregulation of extracellular matrix proteins in obese adipose tissue (AT) induces systemic insulin resistance. The metabolic roles of type VI collagen and its cleavage peptide endotrophin in obese AT are well established. However, the mechanisms regulating endotrophin generation remain (...)

30 June

Diabetes https://diabetes.diabetesjournals.org

• 02:00
  Characterization and Clinical Association of Autoantibodies Against Perilipin 1 in Patients With Acquired Generalized Lipodystrophy Diabetes
  Acquired generalized lipodystrophy (AGL) is a rare condition characterized by massive loss of adipose tissue through the body, causing severe metabolic complications. Autoimmune destruction of adipocytes is strongly suspected based on the frequent association of AGL with autoimmune disorders. (...)

24 June

Diabetes https://diabetes.diabetesjournals.org

• 02:00
  Issues and Events Diabetes

16 June

Diabetes https://diabetes.diabetesjournals.org

• 02:00
  Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy Diabetes
  Acquired lipodystrophy is often characterized as an idiopathic subtype of lipodystrophy. Despite suspicion of an immune-mediated pathology, biomarkers such as autoantibodies are generally lacking. Here, we used an unbiased proteome-wide screening approach to identify autoantibodies to the (...)

1 June

Diabetes https://diabetes.diabetesjournals.org

• 02:00
  718-P: Patients Achieving an HbA1c <5.7% with =5% Weight Loss and without Hypoglycemia: A Post Hoc Analysis of SURPASS 1 to 5 - CHENG AY, LINGVAY I, CHOUDHARY P, et al. Diabetes
  In the phase 3 SURPASS studies of tirzepatide (TZP) , a novel dual GIP/GLP-1 receptor agonist developed for the treatment of type 2 diabetes, 23%-62% of TZP-treated participants achieved a HbA1c Disclosure A.Y. Cheng: Advisory Panel; Abbott, AstraZeneca, Bayer AG, Boehringer Ingelheim (...)
• 02:00
  794-P: Real-World Uses and Challenges with Hybrid Closed-Looped Systems among Adolescents with T1D - MORROW T, OKONKWO N, JASER SS. Diabetes
  Previous research on hybrid closed loop (HCL) systems has demonstrated their potential to improve glycemic outcomes and reduce the burden of diabetes care for people with T1D. We sought to describe adolescents' real world use the 670G Medtronic and Tandem Control IQ (CIQ) systems including the (...)
• 02:00
  795-P: Significance and Future Trends of AID Systems from the Perspective of Physicians - HEINEMANN L, HERMANNS N, EHRMANN D, et al. Diabetes
  Aims: How do physicians assess AID-Systems in terms of their current and future importance for diabetes care?Methods: In 2021 3diabetologists in Germany (48% female, average age 53.7 years) were asked via online surveys about their current and future assessment of AID-Systems.The results were (...)
• 02:00
  796-P: Perceived Potential Benefits and Barriers for Using a Bionic Invisible Pancreas - HERMANNS N, FINKE-GROENE K, KULZER B, et al. Diabetes
  A fully implantable automated insulin delivery system consisting of an intraperitoneal pump and an implantable CGM sensor (Bionic Invisible Pancreas - BIP) is under development. The occurrence of potential benefits or barriers to the use of the BIP was assessed in people with diabetes under (...)
• 02:00
  797-P: Usability and Satisfaction of a New Affordable Insulin Pen for All: Positive Outcomes of Two Usability Studies - NIELSEN OK, HUISMAN G, QASEM JA, et al. Diabetes
  Globally, 13 million people (4 million in USA) inject insulin with single use disposable syringes daily. Compared to syringe and vials, pens are known to increase adherence and diabetes control and to reduce healthcare utilization costs. Yet, pens are largely unavailable to low-income groups, (...)
• 02:00
  798-P: A Real-Life Experience with Hybrid Closed-Loop Insulin Delivery Systems in People with Type 1 Diabetes: One Year After - CONVERTINO A, GIULIANI C, BITTERMAN O, et al. Diabetes
  Objective: evaluate the metabolic impact and metrics of the new hybrid closed loop insulin delivery system on the quality of life in patients with type 1 diabetes.Methods: Metrics obtained with CGM with >80% of CGM readings over a 4-week period in real life: Time in Range (TIR%) [target 70-180 (...)
• 02:00
  799-P: Cognitive Assessment in Elderly with Type 1 Diabetes Mellitus on Insulin Pump: A Cross-Sectional Observational Study - RIZZI A, QUARANTA D, L’ABBATE F, et al. Diabetes
  Aims: Aim of the study was to investigate cognitive performance in elderly with type 1 diabetes (T1DM) on insulin pump (CSII) and the correlation between time in range (TIR) and cognitive scores (CS) . Differences in CS according to duration of disease were also investigated.Methods: Subjects (...)
• 02:00
  79-LB: The Effects of Glucose Reporting Tools on Therapeutic Decision Making—A Comparative Reading Study with Primary Care Providers - NOVAK MT, HAYTER G, WRIGHT E, et al. Diabetes
  The discordance between the amount of new therapies for Type 2 diabetes (T2D) and improved outcomes highlights an unmet need for tools to help primary care providers (PCPs) make appropriate therapy adjustments. Here we present a novel CGM-based Glucose Pattern Insights Report (GPIR) that (...)
• 02:00
  79-OR: Conventionalization from Cecal Transplant Recipients Protects Against Type 1 Diabetes Development in Germ-Free NOD Mice - PAN S, ZHANG X, BLASER MJ. Diabetes
  Early-life antibiotic exposure perturbs the microbiome, dysregulates intestinal immune gene expression, and accelerates and amplifies type 1 diabetes (T1D) development in NOD mice. We have previously shown that cecal microbiota transfer (CMT) from healthy donors rescues antibiotic-induced T1D (...)
• 02:00
  7-LB: Gender Differences in Reported Consequences of Level 2 and Level 3 Hypoglycemia among Adults Living with Type 1 Diabetes—A BETTER Registry Analysis - TALBO MK, LEBBAR M, MESSIER V, et al. Diabetes
  Introduction: Hypoglycemia is a common side effect of type 1 diabetes (T1D) therapy with consequences ranging from physical and cognitive impairment to reduced quality of life. Studies evaluating consequences of level 2 (L2H, glucose levelDisclosureM. K. Talbo: None. M. Lebbar: None. V. (...)
• 02:00
  7-OR: Distinct Developmental Origins of Brown Adipose Tissue at Different Anatomical Locations - RUAN H, ZHANG Z, HUANG Z. Diabetes
  Brown adipose tissue (BAT) is a thermogenic organ that promotes metabolic fitness. In humans, there are two spatiotemporally distinct phases of BAT ontogeny: the prenatally developed dorsal-anterior-located interscapular and retroperitoneal BAT; and the postnatally emerged anterior cervical and (...)
• 02:00
  800-P: Real-World Use of Do-It-Yourself Artificial Pancreas Systems in Adults with Type 1 Diabetes - AMUEDO S, ANTEQUERA M, AZRIEL S. Diabetes
  Background and Aims: Members of the diabetes community have started developing their own Do-It-Yourself Artificial Pancreas Systems (DIY APS) , also known as Open-Source Automated Insulin Delivery (AID) Systems and use the online hashtag “#WeAreNotWaiting” to promote the development of it. DIY (...)
• 02:00
  1050-P: COVID-Severity and Diabetes in Pregnancy - RIVERA A, PAUL R, FROLOVA AI, et al. Diabetes
  Diabetes and pregnancy are independently associated with increased risk of severe COVID-infection. However, little is known about the relationship between severe COVID-and diabetes in pregnancy. We sought to determine whether diabetes in pregnancy was associated with increased risk of (...)
• 02:00
  1073-P: Accelerometer-Derived Movement Patterns in Older People with Diabetes and Varying Functional Status - YAHALOM-PERI T, KODESH E, BASSON-SHLEYMOVICH Y, et al. Diabetes
  Introduction: Type 2 Diabetes (T2D) is associated with reduced muscle mass, strength and function leading to frailty and disability. Little is known regarding the continuous movement patterns and glucose fluctuation in these functional states. Aims: To identify differences in movement patterns (...)
• 02:00
  1074-P: Variation in Predicted Fracture Risk by Diabetes and Obesity Status in Older U.S. Asian and White Women - LO JC, CHANDRA M, GORDON NP, et al. Diabetes
  Introduction: Diabetes (DM) is a risk factor for fracture but women with DM have less osteoporosis by bone density (BMD) , due in part to higher body mass index (BMI) . The FRAX fracture risk calculator incorporates age, race/ethnicity, BMD, BMI, and other risk factors but not DM. Few studies (...)
• 02:00
  110-LB: Management of Alpelisib-Induced Hyperglycemia - WEINTRAUB M, LIU D, FLORY J. Diabetes
  The phosphoinositide 3-kinase (PI3K) pathway is a common target for oncologic therapies and mediates much of insulin’s action. The PI3K? inhibitor alpelisib is effective in advanced breast cancer but causes hyperglycemia in up to 80% of patients. The FDA label recommends metformin as first-line (...)
• 02:00
  1124-P: Hemoglobin A1c and BMI Are Not Correlated in Patients with Prediabetes - SINGH G, HOWLAND T, SHAKJIRI B, et al. Diabetes
  The correlation between the hemoglobin A1C and BMI in patients with type 2 diabetes is well established. The present study was undertaken to examine whether a similar correlation is present in patients with prediabetes. Between 2017 and 2021, patients within the Ascension Lourdes primary care (...)
• 02:00
  1125-P: Obstructive Sleep Apnea and Insomnia Are Highly Prevalent in Monogenic Diabetes - AROSEMENA MA, WROBLEWSKI K, TASALI E, et al. Diabetes
  Background: Sleep disorders are highly common in type 1 and type 2 diabetes with important cardiometabolic implications. Maturity Onset Diabetes of the Young (MODY) has unique features compared to type 1 or type 2 diabetes, such that patients are generally lean and not using insulin.Objective: (...)
• 02:00
  1126-P: A New Prostate-Specific Antigen Threshold for Screening Prostate Cancer among Diabetic Patients - LIU C, CHEN Y, LIU J, et al. Diabetes
  Background: The level of prostate-specific antigen (PSA) was reported to be reduced in type 2 diabetes mellitus (T2DM) . Possible low PSA levels in T2DM patients reduce the sensitivity of prostatic cancer (PCa) screening. To improve the effectiveness of early PCa screening inT2DM, it is (...)
• 02:00
  1127-P: Diabetes Risk in Marginalized Urban Settings in Mexico City - SILVA-TINOCO R, BOUCHAN-DELINO S, SR., REVUELTA-LARA L, et al. Diabetes
  Type 2 diabetes (T2D) is a leading cause of morbidity and mortality in Mexico. Routine identification of persons with high risk for developing T2D is poorly executed in low- and middle-income countries. Thus, we aimed to analyze the characteristics of participants of a public health initiative (...)
• 02:00
  1372-P: Hyperglycemia Impacts Mouse Skeletal Muscle in a Sex-Specific Manner - KNAUB L, POTT G, HULETT NA, et al. Diabetes
  Functional Exercise Capacity (FEC) , a universal predictor of cardiovascular and all-cause mortality, is lower in adults and youth with diabetes for reasons that are poorly understood. Skeletal muscle is key determinant of FEC. We hypothesized that skeletal muscle capillary and mitochondrial (...)
• 02:00
  1373-P: Changes in Body Composition Are Associated with Improvement of ß-Cell Function and Insulin Sensitivity after Short-Term Intensive Insulin Therapy in Patients with Newly Diagnosed Type 2 Diabetes - XU C, LI Y, LIU L. Diabetes
  Objective: To investigate the change of muscle strength and body composition during short-term intensive insulin therapy (SIIT) and their association with treatment effects in patients with newly diagnosed type 2 diabetes (T2DM) .Research Design and Method: Patients with newly diagnosed T2DM (...)
• 02:00
  1374-P: In Type 2 Diabetes, the Exocrine Pancreas Has Greater Fibrosis, Fat, Metaplastic Changes, and Microangiopathy - WRIGHT JJ, ESKAROS A, WINDON AL, et al. Diabetes
  Type 2 diabetes (T2D) is associated with increased risk of pancreatic cancer. Our knowledge of exocrine pancreas histopathology in T2D is incomplete. To determine whether T2D is associated with changes in the pancreatic exocrine compartment, we analyzed tissue sections from the pancreatic head, (...)
• 02:00
  1447-P: The Snd1 Coregulator Controls ß-Cell Function - KANOJIA S, DAVIDSON RK, SPAETH J, et al. Diabetes
  The main function of the pancreatic ?-cell is glucose-stimulated insulin secretion (GSIS) which serves to maintain whole body glucose homeostasis. Under type 2 diabetic conditions, a subset of ?-cells fail and lose expression of key transcription factors (TFs) required for GSIS. Among these TFs (...)
• 02:00
  1448-P: Partial Pancreatectomy Increased ?-Cell Volume Density, but Not Compensated ß-Cell Volume in Japanese Subjects - TAKEUCHI Y, MIZUKAMI H, OSONOI S, et al. Diabetes
  In type 2 diabetes, deficit of insulin secretion is often ascribed to the reduction of ?-cell volume, implying that regeneration of ?-cells could be one of its radical treatments. Hitherto, several models are known to elicit ?-cell compensation in rodents. Among them, application of partial (...)
• 02:00
  1449-P: Reducing Ghrelin Levels as a Novel Method to Increase Pancreatic Beta-Cell Mass - GUPTA D, BURSTEIN AW, SHANKAR K, et al. Diabetes
  Objective: Exogenous insulin remains the leading therapy for type 1 diabetes mellitus, T1D. However, current insulin formulations and delivery methods do not match the precision of functioning beta-cells, and even intensive monitoring of blood glucose and use of insulin pumps are not enough to (...)
• 02:00
  144-LB: Pediatric Type 2 Diabetes Prevalence from Real-World Data in the United States - CHAO L, VIDMAR A, ESPINOZA J. Diabetes
  Background: The SEARCH for Diabetes in Youth Study has provided critical insights into the epidemiology of pediatric T2D. The 2021 report estimated an annual percent change (APC) in prevalence of 4.8% between 2009 to 2017. Multi-center longitudinal cohort studies generate robust data, but are (...)
• 02:00
  144-OR: Adipose Modeling of FGF21 Signaling Mutations in a Severe Insulin Resistance Syndrome - PHAN N, ORNITZ DM, STONE SI. Diabetes
  Insulin-mediated pseudoacromegaly (IMPA) is a rare, severe insulin resistance syndrome characterized by tall stature, acanthosis nigricans, obesity, and acromegalic features. Patients with IMPA have normal growth hormone and IGF-1. However, they have markedly increased insulin levels. Our group (...)
• 02:00
  149-LB: Pediatric Exogenous Insulin Antibody Syndrome—Successful Treatment with Mycophenolate Mofetil - SABA L, ORANDI AB, PITTOCK S, et al. Diabetes
  Case Description: A lean, 17-year-old Caucasian male with type 1 diabetes diagnosed at age 9 experienced an abrupt increase in his insulin requirements. He was managed on mixed daily injections. Daily insulin requirements increased from 1.7 units/kg/day to 3.3 units/kg/day over 6 months. His (...)
• 02:00
  149-OR: Genetic Modulation of HNF1A Activity via SGLT2 Deficiency Leads to Transient Intermittent Hyperglycemia: Consequences for HNF1A-MODY - ACOSTA-MONTALVO A, SAPONARO C, THEVENET J, et al. Diabetes
  Hepatocyte Nuclear Factor-1A (HNF1A) is a master regulator of key glucose-responsive genes in metabolic organs such as the intestine, liver, kidney, and pancreas. Heterozygous mutations in HNF1A cause Maturity-Onset-Diabetes-of-the-Young (HNF1A-MODY) . Mutant carriers are normoglycemic in (...)
• 02:00
  14-LB: Clinical Utility of KidneyIntelX on Patients with Early-Stage Diabetic Kidney Disease—A Real-World Evidence Study - TOKITA J, DONOVAN MJ, FIELDS R. Diabetes
  Introduction: KidneyIntelX is a multiplex immunoassay of 3 plasma biomarkers with 7 clinical variables combined using machine-learning to generate a risk score for progressive decline in kidney function over 5 years in individuals with early-stage diabetic kidney disease (DKD) .Methods: A (...)
• 02:00
  14-OR: Harmine and Exenatide Combination Increases Human ß-Cell Survival - ROSSELOT C, LI Y, GUEVARA D, et al. Diabetes
  GLP1R agonists such as Exendin-4 (E) together with DYRK1A inhibitors such as Harmine (H) significantly increase human ?-cell replication in vitro and in vivo. Importantly, 3-month treatment with H+E combination markedly increases human beta cell mass (?7-fold) in islets transplanted in (...)
• 02:00
  20-LB: Heart Failure Hospitalization among African American Compared with White Individuals with Type 2 Diabetes on Empagliflozin—Real-World Data - MISHRIKY BM, CUMMINGS DM, FU Y, et al. Diabetes
  While African Americans (AA) were underrepresented in the SGLT2i CVOT, the results from those trials were generalized to all, regardless of race. Our goal was to evaluate the risk of heart failure hospitalization (hHF) among AA vs. White (Wh) vs. Hispanic (His) patients with type 2 diabetes (...)
• 02:00
  20-OR: The Renal and Vascular Effects of Combined SGLT2 and Angiotensin Converting Enzyme Inhibition - LYTVYN Y, KIMURA K, PETER N, et al. Diabetes
  The goal of this mechanistic trial was to determine the kidney and cardiovascular effects of combined treatment with an SGLT2i (empagliflozin 25mg QD) and an ACEi (ramipril 10mg QD) for 4 weeks in patients at risk of renal hyperfiltration.In this randomized, double-blind, placebo-controlled, (...)
• 02:00
  210-LB: Central Regulation of Peripheral Adiposity by Nos1PVHNeurons - FAULKNER LD, LEWIS K, MEEK TH, et al. Diabetes
  Within the CNS, the paraventricular nucleus of the hypothalamus (PVH) is critical for energy homeostasis, as developmental or mechanical lesions targeting the PVH lead to massive obesity. The PVH is composed of multiple cell types expressing an assortment of neuropeptides, receptors, and (...)
• 02:00
  210-OR: Presence of Type 2 Diabetes (T2D) Affects HDL Particle Proteomic Composition Independently of Obesity or Fatty Liver - BRIL F, PEARCE R, COLLIER TS, et al. Diabetes
  Patients with T2D remain at high risk of cardiovascular (CV) events despite adequate glycemic and LDL-C control. Changes in HDL particle composition and function may explain part of this increased CV risk. The aim of this study was to determine the proteomic composition of isolated HDL (...)
• 02:00
  211-LB: The Islet Tester Mouse, a Stable and Reproducible In Vivo Model to Study Human Islet Function - WAITE E, MAY CL, PANCREAS ANALYSIS PROGRAM (HPAP) H, et al. Diabetes
  The current gold standard for assessing the function of human islet in vivo, is to engraft islets under the kidney capsule of hyperglycemic, immunodeficient mice. Current models, such as Streptozotocin (STZ) treatment or NSG-Akita mice, are limited due to instable hyperglycemia and/or morbidity (...)
• 02:00
  211-OR: Plasma Insulin Is Required for the Increase in Plasma ANGPTL8 Concentration following Glucose Ingestion - ABU-FARHA M, ABUBAKER J, KHAIRI I, et al. Diabetes
  Aim: ANGPTL8 plays an important role in regulating lipoprotein lipase activity. Its plasma level is increased following nutrient ingestion. Its not well characterized whether insulin or glucose drive the increased ANGPTL8 after food uptake. To address this, we examined the dynamic relationship (...)
• 02:00
  212-LB: Decreasing Drp1 Expression in Mouse Liver Activates the Mitochondrial Integrated Stress Response and Exacerbates NASH - STEFFEN J, NGO J, WANG S, et al. Diabetes
  Elevated Drp1-mediated mitochondrial fission was proposed to promote NAFLD, as inhibition of hepatic Drp1 in early life prevented high-fat diet induced liver steatosis in mice. However, whether Drp1-knockdown (Drp1si) can reverse established NASH in adulthood is unknown. Hepatocyte-restricted (...)
• 02:00
  212-OR: Five-Year Follow-Up of Lipid, Inflammatory, Hepatic, and Renal Markers in People with T2 Diabetes on a Very-Low-Carbohydrate Intervention Including Nutritional Ketosis (VLCI) via Continuous Remote Care (CRC) - ROBERTS CP, ATHINARAYANAN SJ, VANTIEGHEM M, et al. Diabetes
  Objective: To address the long-term effectiveness of VLCI for T2D, we report changes in lipids, inflammatory, hepatic, and renal markers at 5y.Research Design and Methods: Of the 200 subjects with T2D reaching 2-years in a non-randomized, controlled trial of CRC emphasizing VLCI, 169 (84.5%) (...)
• 02:00
  213-LB: Combined Oral Contraceptives Drive Inactivity and Hepatic Mitochondrial Oxidative Stress in Female Mice - FULLER K, MCCOIN CS, STIERWALT H, et al. Diabetes
  Background: It is well established that compared to age-matched men, pre-menopausal women are protected against metabolic disease (obesity, diabetes, hepatic steatosis) . However, both epidemiological data on menopause and pre-clinical ovariectomy models show that disruption of estrogen (...)
• 02:00
  213-OR: Antidiabetic Potential of Novel, Long-Acting Amylin Analogue ZP8396 in ZDF Rats - SKARBALIENE J, BAADER-PAGLER T, ERIKSSON P. Diabetes
  Amylin improves glucose homeostasis through at least three distinct mechanisms of action, including prevention of the postprandial rise in plasma glucagon, slowing of gastric emptying, and increased satiety, leading to decreased caloric intake and potential weight loss. Clinical efficacy has (...)
• 02:00
  214-LB: Activating and Disrupting the Liver–Alpha-Cell Axis Respectively Enhances and Impairs Amino Acid Metabolism and Alpha-Cell Growth - CHRISTENSEN EE, GALSGAARD KD, JOHANSEN CD, et al. Diabetes
  Amino acids control alpha cell secretion and growth, while glucagon stimulates hepatic amino acid uptake and ureagenesis, forming the liver-alpha cell axis. Patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes have increased levels of glucagon and amino acids pointing to a (...)
• 02:00
  292-OR: Changes in Glycemia during Exercise Differ for Aerobic, Interval, and Resistance Workouts with No Impact of Insulin Delivery Modality for Adults with Type 1 Diabetes (T1D) - RIDDELL M, PATTON SR, MARTIN CK, et al. Diabetes
  Glycemic responses differ by exercise classification (i.e. aerobic, interval, resistance) in individuals with T1D, but the impact of insulin delivery modality (multiple daily injections [MDI], pump, closed loop) on these differences is unclear. Data from the Type 1 Diabetes Exercise Initiative (...)
• 02:00
  293-OR: Effects on Metabolic Control and Body Composition of Insulin Therapy Optimization in Patients with Cystic Fibrosis–Related Diabetes - GRANCINI V, PORCARO LL, GAGLIO A, et al. Diabetes
  Cystic fibrosis related diabetes (CFRD) occurs in 19% of adolescents and 40-50% of adults with CF. The partial to complete insulin deficiency leads not only to hyperglycaemia, but also to loss of muscle mass and induction of a catabolic state. Therefore, insulin is the only recommended therapy (...)
• 02:00
  294-OR: The Type 1 Diabetes Protective Variant of Tyrosine Kinase 2 (TYK2) Protects ß-Cells from Autoimmunity - TAMAYO A, HUBER M, BUTFILOSKI EJ, et al. Diabetes
  Type 1 diabetes (T1D) is a complex autoimmune disease where genes and environmental factors impact pathogenesis. Analysis of the >150 loci identified by GWAS reveals the compelling theme that candidate genes cluster into pathways. A pathway connecting environment to T1D genetics is the (...)
• 02:00
  295-OR: Identification of Type 1 Diabetes Genes and Regulatory Processes Mediating Pancreatic Beta-Cell Survival in Response to Proinflammatory Cytokines - BENAGLIO P, ZHU H, OKINO M, et al. Diabetes
  The response of beta cells to inflammatory cytokines contributes to type 1 diabetes (T1D) risk, but the specific genes that underlie this response and mediate beta cell survival remain largely unknown. In this study we used a suite of functional genomics assays combined with human genetics, to (...)
• 02:00
  296-OR: Single-Cell Multiomic Analysis of the Human Pancreas in Type 1 Diabetes - MELTON R, BEEBE E, ZENG C, et al. Diabetes
  The cis-regulatory programs of specific cell types in the pancreas that are affected in type 1 diabetes (T1D) are poorly understood. Single cell technology enables detailed interrogation of genomic profiles of cell types within a heterogeneous tissue, and when applied to samples across disease (...)
• 02:00
  297-OR: TXNIP DNA Methylation (DNAme) and Long-Term HbA1c in Type 1 Diabetes (T1D) - MILLER RG, MYCHALECKYJ J, ONENGUT-GUMUSCU S, et al. Diabetes
  DNAme is associated with past HbA1c in DCCT/EDIC but these associations were examined when there was separation in HbA1c distribution by trial intervention arm. Thus, we performed an epigenome-wide association study (EWAS) of DNAme and HbA1c in a T1D cohort without intervention or risk factor (...)
• 02:00
  298-OR: Variant-to-Gene Mapping at the Childhood Obesity Locus on chr12q13 and Subsequent Luciferase Assay Analyses Implicate rs71329as a Causal Variant within the 3’ UTR of FAIM2 - LITTLETON SH, BRADFIELD J, PIPPIN JA, et al. Diabetes
  A key limitation of genome-wide association studies (GWAS) is that they do not specify either the underlying causal variant (s) or the effector gene (s) at a given locus. The widely reproduced obesity FAIM2 locus, named arbitrarily after the nearest gene, is relatively understudied given it is (...)
• 02:00
  299-OR: Molecular and Physiological Consequences of the Diabetes-Related PGC1A Gly482Ser Polymorphism - GALIPEAU M, JOUVET N, COURTY E, et al. Diabetes
  Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1A) is a nuclear transcriptional coregulator that plays a major role in the control of metabolism and mitochondrial biogenesis. We showed that a diabetes-linked single nucleotide polymorphism (SNP rs8192678) within the (...)
• 02:00
  29-LB: Investigating the Molecular Basis of the Microbiota-Mediated Regulation of Postprandial Chylomicron Production - ABDALQADIR NS, ADELI K. Diabetes
  Obesity and insulin resistance have been identified as major global health concerns. They are associated with increased intestinal chylomicron production and subsequent remnant lipoprotein accumulation which lead to postprandial dyslipidemia. Dietary composition influences metabolic output of (...)
• 02:00
  334-OR: Pemvidutide (ALT-801) , a Balanced (1:1) GLP-1/Glucagon Dual Receptor Agonist, Induces Rapid and Marked Weight Loss without the Need for Dose Titration in People with Overweight/Obesity - KLEIN S, NESTOR JJ, JR., HARRIS M, et al. Diabetes
  Background: Weight loss is the cornerstone of therapy for people with overweight/obesity. Pemvidutide is a dual GLP-1/glucagon receptor agonist that provides GLP-1/glucagon agonism in a balanced (1:1) ratio, which is hypothesized to enhance weight loss and minimize gastrointestinal (...)
• 02:00
  550-P: A Randomized Trial of Low-Carbohydrate Diet on Hemoglobin A1c among Individuals with Elevated Hemoglobin A1c - DORANS KS, BAZZANO LA, QI L, et al. Diabetes
  Background: Low-carbohydrate diets decrease hemoglobin A1c among patients with type 2 diabetes mellitus. However, evidence on effects of low-carbohydrate diets on hemoglobin A1c among individuals with prediabetes is limited.Methods: We conducted a randomized parallel-group trial of 150 adults (...)
• 02:00
  551-P: Effects of a Plant-Based Intensive Lifestyle Intervention in Adults with Type 2 Diabetes: A Randomized Controlled Trial - HANICK C, PETERSON CM, SABATÉ J, et al. Diabetes
  Background: The Republic of the Marshall Islands (RMI) has the highest rate of type 2 diabetes (T2D) in the world. Lifestyle interventions, including plant-based diets and exercise, have been shown to effectively manage T2D.Objective: We therefore conducted the largest plant-based lifestyle (...)
• 02:00
  552-P: Changes in Food and Nutrient Intake and Diet Quality on a Low-Fat Vegan Diet Are Associated with Changes in Body Weight and Body Composition in Overweight Adults: A Randomized Clinical Trial - KAHLEOVA H. Diabetes
  Objective: The aim was to identify changes in food, nutrient intake, and diet quality on a low-fat vegan diet and associations with changes in body weight and body composition.Methods: Overweight adults (n=244) were randomly assigned to follow a low-fat vegan diet (n=122) or make no diet (...)
• 02:00
  553-P: Changes in Circulating Bile Acids and the Improvements in Glucose and Insulin Metabolism in Response to Weight-Loss Diets: The POUNDS Lost Trial - HEIANZA Y, WANG X, MA H, et al. Diabetes
  Bile acids (BAs) are synthesized from cholesterol in the liver and are essential for nutrient absorption. The host-derived primary BAs are transformed into secondary BAs in the intestine. Various BA subtypes may play pivotal roles as endocrine molecules to affect glucose and insulin metabolism. (...)
• 02:00
  554-P: Complex Meal Handling with Advanced Hybrid Closed-Loop (AHCL) System - HIRSH M, SHALIT R, SHALEM S, et al. Diabetes
  Background and Aims: Meal management is a major challenge for people with type 1 diabetes (PWD) . We aimed to explore 3 approaches to complex meal planning, from a most comprehensive scheme in open loop (OL) to a simplified, carbohydrate (CHO) counting-free scheme when using the MiniMed™ 780G (...)
• 02:00
  555-P: Premenopausal vs. Postmenopausal Women: Effect of Time-Restricted Eating on Body Weight and Metabolic Health Markers - GABEL K, VARADY K, CIENFUEGOS S, et al. Diabetes
  Background: Time restricted eating (TRE) involves restricting the ad libitum eating window to a specific number of hours daily, while water fasting for the remaining hours.Objective: This study examined if changes in body weight and metabolic risk factors during TRE, differ in women based on (...)
• 02:00
  556-P: The Relationship between Short-Chain Fermentable Carbohydrates (FODMAPs) , Gut Microbiome, and Glucose Intolerance: An Exploratory Analysis - CHU N, HE J, MA RC, et al. Diabetes
  Fermentable oligo-, di-, monosaccharides, and polyols (FODMAPs) are fermentable short-chain carbohydrates that include fructans, galactooligosaccharides (GOS) , lactose, excess fructose, mannitol and sorbitol. Low FODMAP diets in irritable bowel syndrome were associated with reductions in (...)
• 02:00
  557-P: Effect of Monocarbonyl Curcumin Analogues C66 and B2BrBC on Pancreatic Expression of Genes Related to Insulin Signaling Pathway and Oxidative Stress in Streptozotocin-Induced Diabetes - STOJCHEVSKI R, ANGELOVSKI M, VELICHKOVIKJ S, et al. Diabetes
  Curcumin has well documented beneficial effects against diabetes but its poor bioavailability limits its use. Here, we investigated the effects of two monocarbonyl curcumin analogues - (2E,6E) -2,6-bis[ (2-trifluoromethyl) benzylidene]cyclohexanone (C66) and (2E,6E) -2,6-bis (...)
• 02:00
  558-P: Effect of Vitamin D Supplementation on Regression to Normal Glucose Regulation from Prediabetes in the D2d Study - HSIA DS, NELSON JP, VICKERY E, et al. Diabetes
  Regression to normal glucose regulation (NGR) has been reported in response to lifestyle modification and medications. In this secondary analysis of the D2d study, a randomized trial of 4,000 IU/d of vitamin D3 vs. placebo, we determined whether vitamin D increased regression to NGR in people (...)
• 02:00
  703-P: Significant Weight Reduction and Improvement in Glycemic Control among People with T2D after Participation in Diabefly Digital Therapeutics Program - VERMA R, KHADER MA, MALDE F, et al. Diabetes
  Background: Digital therapeutics platforms provide accessible and multidisciplinary care for the management of T2D. The current study explored the effectiveness of the Diabefly program for improving glycemic control in people with T2D.Methods: Diabefly program provides a combination of mobile (...)
• 02:00
  704-P: Time in Range and Time Below Range in Insulin-Treated Older Adults with Type 2 Diabetes - LEITE SO, SILVA M, LAVALLE AR, et al. Diabetes
  Hypoglycemia is the key limiting step for optimizing glycemic control in older adults. Continuous glucose monitoring (CGM) technology has not been well-evaluated in insulin treated older patients with type 2 diabetes (T2D) .Methods: This prospective observational cohort study assessed of (...)
• 02:00
  705-P: CGM Attitudes and Adoption among People with Type 2 Diabetes Using One Drop - SEARS L, IMRISEK SD, HOY-ROSAS JR, et al. Diabetes
  Background: Despite research establishing the strong benefits of continuous glucose monitors (CGMs) in the management of diabetes, adoption remains low among people with type 2 diabetes (T2D) . The present mixed-method study describes CGM attitudes and use among people with T2D.Method: Members (...)
• 02:00
  706-P: CGM Disruption: A Common Phenomenon - CEDENO A, KRUTILOVA P, MARKOV A, et al. Diabetes
  Background: Advances in diabetes technology have led to reliance on continuous glucose monitors (CGM) for glycemic management. Insufficient wear time due to device malfunction, insertion problems, displacement or removal for imaging, medical procedures or hospitalization is common. Prescription (...)
• 02:00
  707-P: Effectiveness of Breathe Well-Being Diabetes Reversal Program in Achieving Diabetes Remission - GOYAL PK, PATRA SK, KAICKER A, et al. Diabetes
  Introduction: Breathe Well-being Diabetes Reversal Program (BDRP) provides personalized Lifestyle Management (LSM) including coaching on diet and exercise as needed by individuals with type 2 diabetes mellitus (T2DM) along with tracking their blood glucose levels, weight, and physical (...)
• 02:00
  708-P: Hypertension Control among People with Diabetes Using a Self-Management Multicondition Digital Platform - HERSHCOVITZ Y, TAMIR M, MANEJWALA O. Diabetes
  Introduction: Digital multicondition platforms seek to assist persons with diabetes in management of their diabetes and comorbidities. Hypertension is reported in over two-thirds of patients with type 2 diabetes. Both are major risk factors for cardiac, stroke, and kidney disorders. Dario’s (...)
• 02:00
  709-P: Persons with High-Risk Diabetes, Depression, and Stress Using a Digital Health Platform Experience an Improvement in Glycemic Management - HERSHCOVITZ Y, TAMIR M, RITHOLZ MD, et al. Diabetes
  Introduction: As the prevalence of type 2 diabetes (T2D) continues to grow worldwide, individuals struggle with how to integrate diabetes self-management into their lives. This is complicated by the high rate of depression and stress among persons with T2D. A multicondition behavior (...)
• 02:00
  70-LB: Lower A1C with Real-Time CGM than with Intermittently-Scanned CGM after One Year—The CORRIDA LIFE Study - RADOVNICKÁ L, HÁSKOVÁ A, DO Q, et al. Diabetes
  We investigated the efficacy of real-time continuous glucose monitoring (rtCGM) and intermittently scanned continuous glucose monitoring (isCGM) on change in A1C. CORRIDA LIFE was a 12 month, real-world, non-randomized trial that assessed the impact of rtCGM (Dexcom G5 or G6) vs. isCGM (...)
• 02:00
  70-OR: Association of Diabetes Screening with Demographic, Neighborhood Level Census, and Area Gentrification Characteristics - THOMAS T, DYER WT, RODRIGUEZ LA, et al. Diabetes
  Research assessing predictors of preventive screening often focuses on individual patient factors, despite known relationships between neighborhood environment and health. Using a retrospective cohort study of 519,826 patients meeting US Preventive Service Task Force guideline recommendation (...)
• 02:00
  710-P: In Patients with Type 2 Diabetes Mellitus (T2DM) , Continuous Glucose Monitoring System (CGMS) Usage Does Not Alter Multiple Measures of Glycemic Variability (GV) - LEE Y, MEHFOOZ A, WANG Q, et al. Diabetes
  Background: The RCT data on CGMS and GV in patients with T2DM have used limited measure of GV metrics. In patients with T2DM on CGMS, we examined whether the use of blinded or unblinded CGMS will affect their GV across a broad swatch of metrics.Methods: A randomized control study involving 40 (...)
• 02:00
  711-P: User Acceptability of Ecological Momentary Assessment to Report Hypoglycemia over Ten Weeks Using a Novel Smartphone Application in the Hypo-METRICS Study: Hypoglycemia Measurements, Thresholds and Impacts - ZAREMBA N, MARTINE-EDITH G, DIVILLY P, et al. Diabetes
  Background: Hypoglycemia and its impact on people with diabetes is typically reported retrospectively and is subject to recall bias. Ecological momentary assessment (EMA) uses repeated sampling to collect real time, granular data about patient experiences, typically over 3-5 days. We developed (...)
• 02:00
  712-P: Suhoor Timing in T1DM Patients Fasting during Ramadan: A Randomized Crossover Trial - ALAMOUDI R, ALASSIRI MA, ALJAWHRJI A, et al. Diabetes
  IDF-DaR guidelines recommend late Suhoor (pre-dawn meal) , this does not give much time for correction and can lead to breaking the fast in the early hours.Objective: To estimate Hypoglycemia risk in T1D fasting Ramadan when eating Suhoor 90-120 minutes before dawn versus 30 minutes before (...)
• 02:00
  713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus? - SABOO BD, VYAS TC, CHENNAMSETTI K, et al. Diabetes
  Aim: To decide most appropriate time to measure fasting blood sugar (FBS) using continuous glucose monitoring (CGM) .Methodology: All persons who came to our clinic between 1st March to 30th August’21 were screened. Out of 60 persons with A1c 130mg/dl who were measuring after 7.30am (using (...)
• 02:00
  714-P: Greater Improvement in Insulin Sensitivity Per Unit Weight Loss with Tirzepatide Compared with Selective GLP-1 Receptor Agonism - MATHER KJ, MARI A, LI J, et al. Diabetes
  Tirzepatide (TZP) , a novel GIP-GLP-1 dual agonist, improved fasting measures of insulin sensitivity partially attributable to weight loss in Phase 2 studies. Studies in mice demonstrated that GIP receptor agonism with TZP improved insulin sensitivity independent of weight loss. To further (...)
• 02:00
  715-P: Tirzepatide as Monotherapy Improved Markers of Beta-Cell Function and Insulin Sensitivity in People with Type 2 Diabetes (SURPASS-1) - LEE C, MAO H, THIEU V, et al. Diabetes
  Tirzepatide (TZP) , a novel dual GIP/GLP-1 receptor agonist, led to greater HbA1c, fasting serum glucose and body weight reductions vs. placebo (PBO) in people with early T2D (baseline mean T2D duration 4.7 y and 54% no prior diabetes medications) from the 40-wk SURPASS-1 trial. In a Phase 2b (...)
• 02:00
  716-P: Systolic Blood Pressure Reduction with Tirzepatide across SURPASS Program: A Mediation Analysis Using Weight Loss as a Factor - LINGVAY I, MOSENZON O, BROWN K, et al. Diabetes
  Tirzepatide (TZP) is a novel dual GIP/GLP-1 receptor agonist for the treatment of type 2 diabetes. Across the SURPASS 1-5 clinical studies, TZP 5, and 15 mg demonstrated significant improvements in HbA1c (-1.9 to -2.6%) , body weight (-6.6 to -13.9%) and systolic blood pressure (SBP) (-2.8 to (...)
• 02:00
  717-P: Glycemic Control with Tirzepatide in People with Type 2 Diabetes by Baseline HbA1c =8.5% or >8.5% - ALEPPO G, DE BLOCK C, LEVINE JA, et al. Diabetes
  Tirzepatide, a once weekly GIP/GLP-1 receptor agonist in development for T2D, demonstrated superior glycemic control in the Phase 3 SURPASS clinical trial program. This post-hoc analysis assessed glycemic control with tirzepatide in participants stratified by baseline (BL) HbA1c (?8.5%, >8.5%) . (...)
• 02:00
  1285-P: Differentiating between Diabetic and Idiopathic Gastroparesis: A Genetic Perspective - SMIESZEK SP. Diabetes
  Gastroparesis is a serious medical condition characterized by delayed gastric emptying and symptoms of nausea, vomiting, bloating, fullness after meals, and abdominal pain. An innate immune dysregulation and injury to the interstitial cells of Cajal and other components of the enteric nervous (...)
• 02:00
  1286-P: Plasma-Induced Signatures Measured at Type 1 Diabetes (T1D) Onset Correlate with Post-onset Beta-Cell Function - BEDRAT A, JIA S, ROETHLE M, et al. Diabetes
  Significant phenotypic diversity exists among T1D patients, supporting the existence of distinct disease endotypes (e.g. duration of the post-onset partial remission period) . To broaden our understanding of T1D heterogeneity and its relationship to disease progression and therapeutic (...)
• 02:00
  1287-P: Deep Immune Phenotyping of Type 1 Diabetes by Machine Learning - VERA-RAMOS J, PRIETL B, HERBSTHOFER L, et al. Diabetes
  Breakdown of self-tolerance is an important common mechanism in autoimmunity. We use machine learning (ML) to identify common patterns and dissimilarities between type 1 diabetes (T1D) , rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) based on immune phenotyping. PBMCs were (...)
• 02:00
  1288-P: Increased Adipose Tissue Expression of IL-23 and Its Association with Inflammation in Individuals with High LDL Cholesterol - AHMAD R, KOCHUMON SP, HASAN A, et al. Diabetes
  Obesity induced chronic low-grade inflammation is a central risk factor for the development of metabolic syndrome. It has been well documented that high LDL-c induces inflammation. The proinflammatory cytokine Il-23 plays a pivotal role in the pathogenesis of inflammatory diseases. IL-23 and (...)
• 02:00
  1289-P: Role of Metformin and Lifestyle Modification in Management of Latent Autoimmune Diabetes in Adults - VELAYATI S, SHANIK M, ROMAO IJ. Diabetes
  Introduction: Latent autoimmune diabetes in adults (LADA) is atypical heterogenic diabetes that is frequently misdiagnosed as type 2 diabetes (T2DM) . LADA can demonstrate features of type 1 or T2DM.1 The diagnosis of LADA is well established, however, there are no universally accepted (...)
• 02:00
  1369-P: The Differential Effects of Estrogen on Determinants of Skeletal Muscle Bioenergetics with a High-Fat, High-Sucrose Diet in Rats - HULETT NA, HULL S, KNAUB L, et al. Diabetes
  Estrogen is a powerful, beneficial regulator of skeletal muscle mitochondria. Premenopausal women with type 2 diabetes (T2D) have relatively greater complications associated with their T2D compared with the effect of the disease in men. We hypothesize that this impact of T2D in women is in part (...)
• 02:00
  136-LB: Health Care Professional (HCP) Perspectives on Support Tools for Diabetes Devices - MESSER LH, VIGERS TB, AKTURK HK, et al. Diabetes
  Purpose: To understand the relative importance of support tools for HCPs to increase engagement with diabetes devicesMethods: Primary care, pediatric and adult endocrinology HCPs completed an online survey assessing their comfort with continuous glucose monitors, connected insulin pens, insulin (...)
• 02:00
  136-OR: Polygenic Scores Improve the Predictive Accuracy of Type 1 Diabetes Classification Algorithms in a Large Biobank Cohort - DEUTSCH AJ, MAJARIAN T, MERCADER JM, et al. Diabetes
  Introduction: Many biobanks use machine learning algorithms to predict patient phenotypes such as type 1 diabetes (T1D) . It is not known how these algorithms perform in patients with different ancestral backgrounds or whether incorporating genetic data improves phenotypic (...)
• 02:00
  1370-P: Effects of Concomitant High-Intensity Interval Training or Resistance Exercise Training on Muscle Protein Synthesis, Body Composition, and Metabolic Markers following 6-Week VLCD among Healthy Overweight/Obese Men - AZIZ M, RAMZAN I, GHARAHDAGHI N, et al. Diabetes
  Background: Very Low-Calorie Diet (VLCD) is effective for rapid weight loss but is associated with lean mass (LM) loss. Resistance exercise training (RET) and high-intensity interval training (HIIT) are known to promote muscle hypertrophy or improvements in cardiopulmonary fitness (CPF) . We (...)
• 02:00
  474-P: Efficacy of Saroglitazar on Diabetes Dyslipidemia with Higher Triglyceride - SINHA A. Diabetes
  Objectives: Diabetes and diabetic dyslipidemia with high triglycerides (TGs) are commonly associated. Saroglitazar is the first dual PPAR ?/? agonist which has been approved in India for diabetes dyslipidemia management. This study aimed at evaluation of the efficacy and long-term safety of (...)
• 02:00
  475-P: Plasma Fatty Acid Composition Is Associated with Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Patients - HIGA M, ICHIJO T. Diabetes
  Type 2 diabetes is frequently complicated by nonalcoholic fatty liver disease (NAFLD) , which is mainly caused by high-fat and high-calorie diets, and obesity. In this regard, both the quantity and quality of fat accumulating in the liver are important, and in particular, the proportion of each (...)
• 02:00
  476-P: Role of TGR5 Signalling in Hepatic Lipid and Lipoprotein Metabolism in Normal and Insulin-Resistant States - ALVARES DL, HOFFMAN SS, ADELI K. Diabetes
  Fasting dyslipidemia is characterized by a lipid profile with elevated triglycerides, increased small dense LDL and low HDL-cholesterol, and is a commonly comorbid with insulin resistance. Bile acid (BA) signalling has been suggested to improve hepatic insulin sensitivity and lipid accumulation (...)
• 02:00
  477-P: Vagal GLP-1–Mediated Reductions in Postprandial Lipids Are Sensitive to Fructose Feeding - HOFFMAN SS, ALVARES DC, ADELI K. Diabetes
  Dyslipidemia is a common co-morbidity of insulin resistance, where chronic elevations in hepatic and intestinal lipoproteins are linked to cardiovascular disease. Postprandial production is regulated in-part by gut-derived hormones such as glucagon-like peptide (GLP) -1. Although (...)
• 02:00
  478-P: GALNT2 Variant Associates with Increased ANGPTL3 Circulation Level and Obesity - THANGAVEL AT, ABU-FARHA M, HEBBAR P, et al. Diabetes
  Background: Polypeptide N-Acetylgalactosaminyltransferase 2 (GALNT2) gene has been associated with serum lipid levels, insulin resistance, and adipogenesis. One of its variants, rs4846914 has been shown to associate with Triglycerides and HDL levels in global genome-wide association studies. (...)
• 02:00
  479-P: Lipid Pattern in Men with Hypogonadism and Type 2 Diabetes Receiving Long-Term Testosterone Treatment Compared with an Untreated Control Group: Update of a Real-World Registry - SAAD F, HAIDER KS, HAIDER A. Diabetes
  Background: Previous studies reported inconsistent effects of testosterone therapy on the lipid profile in men with hypogonadism.Methods: Of 370 men with hypogonadism and T2DM, 190 received testosterone undecanoate 1000 mg/12 weeks (T-group) , 180 opted against treatment (CTRL) . Means and (...)
• 02:00
  47-LB: Higher Weight Loss Is Associated with Improved Quality of Life in Patients with Type 2 Diabetes—SURPASS Program - BOYE K, THIEU V, YU M, et al. Diabetes
  In addition to glycemic control, the ADA recommends weight management for patients with type 2 diabetes (T2D) with overweight or obesity. This analysis explored the association between weight loss and patients’ quality of life using pooled data from the SURPASS clinical trials, regardless of (...)
• 02:00
  47-OR: Efficacy, Durability, and Safety of Faricimab in Diabetic Macular Edema: Two-Year Results from the Phase 3 YOSEMITE and RHINE Trials - DANZIG CJ, WELLS JA, EICHENBAUM D, et al. Diabetes
  Diabetic macular edema (DME) is a major cause of vision loss for people with diabetes. Intravitreal anti-vascular endothelial growth factor (VEGF) therapy is the standard of care for DME; however, there is an unmet need for new strategies that address the multifactorial nature of DME, reduce (...)
• 02:00
  480-P: Correlation of Tg/HDL Ratio and Liver Fibrosis in People with Diabetes in a Tertiary Care Center in India - TEWARI A, TEWARI V, TEWARI J, et al. Diabetes
  Introduction: As per the recent International Diabetes Federation (IDF) atlas, there are 537million adults living with diabetes. Indians with the same body mass index (BMI) have higher central adiposity and insulin resistance compared to Caucasians. High insulin resistance in people with (...)
• 02:00
  481-P: Eligibility for Icosapent Ethyl in Patients with Type 2 Diabetes and Atherosclerotic Cardiovascular Disease: An Analysis of VERTIS CV - KIM JM, BHATT DL, DAGOGO-JACK S, et al. Diabetes
  Among patients with type 2 diabetes (T2D) treated with statins, residual cardiovascular (CV) risk remains. Because icosapent ethyl (IPE) has been shown to decrease CV risk in patients on statin therapy, we explored potential eligibility for IPE therapy in VERTIS CV (NCT01986881) , the CV (...)
• 02:00
  821-P: Randomized Clinical Trial on the Renoprotective Effect of CU01-10in Patients with Diabetic Kidney Disease (DKD) - MOON J, WON K, KIM M, et al. Diabetes
  Background: One of the leading causes of chronic kidney disease, DKD is associated with increased oxidative stress and chronic inflammation. CU01-10is dimethyl fumarate (DMF) which being developed for treatment of DKD. DMF attenuated renal fibrosis via the Nrf2-mediated inhibition of (...)
• 02:00
  822-P: The Harmine and Exendin4 Combination Markedly Expands Human Beta-Cell Mass In Vivo in Diabetic Mice - BELIARD KA, ROSSELOT C, LI Y, et al. Diabetes
  Diabetes results from diminished functional ?-cell mass. Small molecule inhibitors of Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) markedly increase human ?-cell replication in vitro and in vivo. Furthermore, combination of DYRK1A inhibitors such as Harmine (H) with (...)
• 02:00
  823-P: The Long-Acting Dual Amylin and Calcitonin Receptor Agonist KBP Has Increased Efficacy on Weight Loss and Glucose Control Compared with Cagrilintide in Obese and Diabetic Rats - LARSEN AT, SONNE N, MOHAMED K, et al. Diabetes
  Long-acting dual amylin and calcitonin receptor agonists (DACRAs) are novel candidates for treatment of type 2 diabetes (T2D) and obesity due to their beneficial effects on both body weight, glucose control and insulin action. Cagrilintide, which is currently in clinical trials, has shown (...)
• 02:00
  824-P: Dual Amylin and Calcitonin Receptor Agonists Improve Insulin Sensitivity and Increase Tissue-Specific Glucose Uptake Independent of Weight Loss - LARSEN AT, SONNE N, BREDTOFT E, et al. Diabetes
  Dual amylin and calcitonin receptor agonists (DACRAs) are known to induce a significant weight loss and improve glucose tolerance and glucose control in rats. However, it is unknown if DACRAs has an insulin sensitizing effect beyond that induced by weight loss and if DACRAs affect tissue (...)
• 02:00
  825-P: Composite Glucose and C-Peptide Endpoints Show Early Efficacy in Recent-Onset Type 1 Diabetes (T1D) Clinical Trials - JACOBSEN LM, CUTHBERTSON DD, HALLER MJ, et al. Diabetes
  C-peptide area under the curve (AUC) at ?1 year, a standard endpoint of recent-onset T1D clinical trials, is derived from a 120-minute mixed meal tolerance test (MMTT) . We analyzed whether composite glucose and C-peptide endpoints, useful in post hoc analyses of prevention trials, could detect (...)
• 02:00
  826-P: Effect of Finerenone on Occurrence of Vision-Threatening Events in Patients with DR - ROSSING P, ANKER S, GARWEG JG, et al. Diabetes
  Finerenone is a potent and selective mineralocorticoid receptor (MR) antagonist that slowed progression of CKD and reduced risk of CV outcomes vs. placebo in patients with CKD and T2D in the FIDELIO-DKD and FIGARO-DKD phase 3 trials. MR overactivation is involved in DR pathogenesis. To evaluate (...)
• 02:00
  827-P: 2022 Update on the BCG Clinical Trial Programs in Advanced Type 1 Diabetes - KUHTREIBER W, HOSTETTER E, LEE AH, et al. Diabetes
  The bacillus Calmette-Guerin (BCG) vaccine was first introduced a century ago for tuberculosis prevention and is today being tested in double-blinded, randomized clinical trials for treatment of diverse forms of autoimmunity, including type 1 diabetes (T1D) and multiple sclerosis (MS) . At our (...)
• 02:00
  828-P: Preservation of ß-Cell Function in Pancreatic Insufficient Cystic Fibrosis (CF) with Highly Effective CFTR Modulator Therapy - FLATT A, SHEIKH S, PELECKIS AJ, et al. Diabetes
  CF related diabetes is common with pancreatic insufficient CF (PI-CF) . Highly effective modulator therapy enhances aberrant CF transmembrane conductance regulator (CFTR) function and improves pulmonary and nutritional status. Ivacaftor therapy for indicated CFTR mutations enhanced insulin (...)
• 02:00
  82-LB: Improvement of Glycemic Control in People with Type 2 Diabetes Using Basal Insulin (PwT2D-BI) and Continuous Glucose Monitoring (CGM) —U.S. Study Using Machine Learning (ML) - CHINTHAMMIT C, BRNABIC AM, PEREZ-NIEVES M. Diabetes
  Background: CGM provide real-time glucose data that allows users to manage their diabetes holistically. This study aimed to assess the association between glycemic control and CGM use in PwT2D-BI.Methods: This retrospective study used IBM MarketScan® 2015 - 2019 Databases to identify PwT2D-BI (...)
• 02:00
  972-P: DKA: Comparing Care in Medical ICU vs. Stepdown in a Community Hospital - AHMAD T, MEHROTRA N, ALI W, et al. Diabetes
  Background: Although DKA has been traditionally managed in intensive care units (ICU) , some studies suggest that DKA can be safely treated in non-critical care areas.Objective: To compare safety & efficacy of a DKA IV insulin protocol in ICU with stepdown unit (SDU) .Methods: A (...)
• 02:00
  973-P: By How Much Does Red Blood Cell Status Affect the Accuracy of HbA1c? - KARWATH A, WILLIAMS JA, ROUND RA, et al. Diabetes
  Medical conditions can affect haematological factors altering relationship between HbA1c and glucose. Patients were recruited at hospital over 3 visits (*1/**2&3 only) comprising 20 with diabetes and in Fig 1 with liver disease (LD) & hepatitis C (HC) on ribavirin*, on dapsone*, with (...)
• 02:00
  974-P: Implementation of Remote Continuous Data Monitoring within a Clinical Setting for the Management of Type 2 Diabetes Mellitus - CACCELLI M, SAID Y, MOJADO JD, et al. Diabetes
  Introduction: The challenge of managing type 2 diabetes mellitus is well known and was especially highlighted during the pandemic. Advances in the use of technology have resulted in improved glycemic control. The GluCare program uses Remote Continuous Data Monitoring (RCDM) and leverages (...)
• 02:00
  105-LB: Glucose Variability with Second-Generation Basal Insulin Analogs Glargine 300 U/mL and Degludec 100 U/mL, Evaluated by CGM in People with T1D—The InRange Randomized Controlled Trial - BERGENSTAL RM, EDELMAN S, CHOUDHARY P, et al. Diabetes
  Background: InRange has previously demonstrated that insulin glargine 300 U/mL (Gla-300) is non-inferior to insulin degludec 100 U/mL (IDeg-100) in terms of time in glucose range 70--180 mg/dL (primary endpoint) and total glucose coefficient of variation (CV) as measured by CGM in people with (...)
• 02:00
  1120-P: Pilot Study Comparison of Newly Developed Pastry Sugar Tolerance Test with the OGTT: Africans in America Study - DUHUZE-KARERA M, YANG S, SCHENK BR, et al. Diabetes
  As undiagnosed diabetes (DM) rises in Africa and A1C performs suboptimally, attention turns to the OGTT. Obtaining Glucola (75g glucose) for the OGTT is difficult. Analyzing Africans in America data, we previously found that duplicate OGTT were highly reproducible for DM detection (k=0.84) ; (...)
• 02:00
  1121-P: The Combination of the ELF and FIB-4 Scores Have High Predictive Performance for Significant or Advanced Fibrosis in Patients with NAFLD - YOUNOSSI Z, FELIX S, JEFFERS T, et al. Diabetes
  Background: Patients with nonalcoholic fatty liver disease (NAFLD) and fibrosis stage ? 2 (F2-F4) are at risk for adverse outcomes and considered to be candidates for clinical trials. We aimed to use two NITs combined to rule in and rule out fibrosis stages F2-F4 among patients with (...)
• 02:00
  1122-P: Subgroup Analysis to Evaluate Individuals at Risk for Incident Diabetes - ITO R, DAIMON M, MIZUSHIRI S, et al. Diabetes
  Since type 2 diabetes (T2D) is a heterogenous disease, treatment of T2D appears to be better personalized depending on their underlining conditions. A recent attempt to classify adult-onset DM based on only 6 DM related variables (GAD antibodies, age at diagnosis, BMI, HbA1c, and HOMA2 indices) (...)
• 02:00
  1123-P: Racial Differences in Glycemia and A1C in the Vitamin D and Diabetes (D2d) Study - LEBLANC ES, PITTAS AG, MONTGOMERY R, et al. Diabetes
  Understanding the association between glycemia and A1c by race can improve screening for prediabetes and type 2 diabetes (T2D) . This association was examined cross-sectionally in 1016 Black and 2658 White persons screened for D2d (mean age 60; fasting glucose [FG] 1mg/dL; A1c 5.9%) . Of these, (...)
• 02:00
  1165-P: Combined Severe Diabetic Complications: The New Life-Altering Outcome - YAGUCHI Y, FUJIHARA K, YAMADA MH, et al. Diabetes
  Since advanced microangiopathy of diabetes severely impairs activities of daily living (ADL) and quality of life (QoL) and macroangiopathy is life-threatening regardless of severity, treatment of diabetes requires appropriate risk management to avoid all such complications. However, current (...)
• 02:00
  1166-P: Distinct Phenotypes of Multiorgan Abnormalities in Long COVID and Type 2 Diabetes Identified by Multiparametric Magnetic Resonance Imaging - EICHERT N, TELFORD A, ROCA-FERNANDEZ A, et al. Diabetes
  Introduction: Both long COVID and Type 2 Diabetes (T2D) are multi-system conditions requiring multi-organ assessment to monitor organ health and detect co-morbidities earlier. Here, we defined multi-organ abnormalities in both patient groups with a rapid, non-contrast MRI scan.Methods: We (...)
• 02:00
  1167-P: Burden of Cardiorenal Complications (CRCs) in T2D: Take Care of Me Programme - KHUNTI K, FENICI P, GONCALVES S, et al. Diabetes
  Rationale: CRCs are known to be key determinants of patient outcomes in T2D; however, the burden of undiagnosed CRCs in unselected T2D population remains unclear, particularly in low-to-middle income countries (LMICs) . ‘Take CaRe of Me’ (TCOM) programme aims to determine the global burden and (...)
• 02:00
  1168-P: Complications in the Second Year of LANDMARC—Longitudinal Nationwide Study on Real-World Outcomes of Type 2 Diabetes in India - RAIS N, DAS AK, JOSHI S, et al. Diabetes
  Macrovascular and microvascular complications were evaluated during the first 2 years of LANDMARC, a 3-year prospective observational study (CTRI/2017/05/008452) that included participants with T2D on ?2 antihyperglycemic medications. Out of 6234 evaluable participants (mean baseline values - (...)
• 02:00
  1236-P: Cardiometabolic Disease Risk in Metabolically Unhealthy vs. Healthy in Normal Weight and Obesity: Results from 2015 and 20KNHNES Data - SEO M, CHO W, ROSENBERG J, et al. Diabetes
  The concept of metabolically unhealthy vs. healthy obese (MUO vs. MHO) was expanded to non-obese individuals as obesity-related comorbidities exist in a subgroup of metabolically unhealthy vs. healthy normal-weight (MUNW vs. MHNW) . It is unclear if MUNW differs from MHO with respect to (...)
• 02:00
  1211-P: Associations of C-peptide, HOMA2, and GADA with Insulin Initiation and Risk of Hypoglycemia in Type 2 Diabetes - FAN B, LAU EH, WU H, et al. Diabetes
  Background: In patients with type 2 diabetes (T2D) and non-ketotic presentation, low C-peptide (CP) and positivity for glutamic acid decarboxylase antibodies (GADA+) indicate early insulin requirement. In GADA- patients, the associations of CP with insulin use, glycemic response and severe (...)
• 02:00
  1212-P: Cost-Related Medication Nonadherence in Alabama's Medicaid Population with Diabetes - NESS EC, JUAREZ L, HOWELL CR, et al. Diabetes
  Background: Cost-related medication nonadherence (CRMN) occurs when an individual takes less medication than what is prescribed due to difficulty affording their medications. In adults with diabetes, medication nonadherence is associated with worse glycemic control and increased healthcare (...)
• 02:00
  1213-P: REVEAL-CKD: Undiagnosed Chronic Kidney Disease in Patients with Type 2 Diabetes in Germany and France - SCHNEIDER MP, VIRGITTI JB, PEACH E, et al. Diabetes
  Background: Early recognition of chronic kidney disease (CKD) is crucial to slow its progression, yet underdiagnosis remains high. This study assesses prevalence of and factors associated with undiagnosed stage 3 CKD in patients with pre-existing type 2 diabetes (T2D) .Methods: REVEAL-CKD is a (...)
• 02:00
  330-OR: Engagement, Satisfaction, and Preliminary Impact of a Personalized Diabetes Chatbot in a Diverse Cohort of Adults with Type 2 Diabetes - MAGEE MF, NASSAR CM, DUNLEA R, et al. Diabetes
  Strategies are needed to expand diabetes education and support among persons with diabetes (PWD) . We designed a personalized conversational agent (“chatbot”) to provide diabetes education and monitoring. Feasibility and preliminary efficacy were assessed in a pilot cohort of adults with type 2 (...)
• 02:00
  331-OR: Gestational Diabetes Knowledge Improves with Interactive Online Training Modules - KRUTILOVA P, WILLIAMS RC, MOREY R, et al. Diabetes
  Background: GDM (gestational diabetes mellitus) increases the lifetime risk of maternal T2DM by 7-fold and increases the risk for maternal and fetal complications. Prenatal education on nutrition, exercise, and T2DM risk among women with GDM increases the likelihood of postpartum diabetes (...)
• 02:00
  332-OR: Success of Virtual Patient Simulation at Improving Comprehensive Management of Type 2 Diabetes - LARKIN A, LACOUTURE M. Diabetes
  We sought to determine if online, virtual patient simulation (VPS) -based continuing medical education (CME) can improve performance of diabetologists/endocrinologists (D/Es) and PCPs in comprehensive management of T2D.Methods: The CME comprised a patient presenting at two different time points (...)
• 02:00
  333-OR: Oxyntomodulin Analog LY3305677 (LY) Improves Glycemic Control and Weight Loss in Healthy Volunteers and Subjects with Type 2 Diabetes (T2D) - BENSON C, THAM L, DU Y, et al. Diabetes
  LY is an acylated peptide analog of oxyntomodulin, a dual glucagon and GLP-1 receptor agonist. We conducted 2 randomized, double-blind, phase 1 multiple ascending subcutaneous dosing studies in healthy subjects (S1, NCT03325387) and in T2D patients (S2, NCT03928379) to evaluate safety, (...)
• 02:00
  389-P: A Six-Month Periodic Fasting Reduces Microalbuminuria and Improves Metabolic Control in Patients with Type 2 Diabetes and Diabetic Nephropathy: A Randomized Controlled Study - SULAJ A, KOPF S, RAUCHHAUPT EV, et al. Diabetes
  Aim: To assess whether periodic fasting reduces albuminuria and activates nephropathy-driven pathways in patients with type 2 diabetes and diabetic nephropathy.Methods: Forty patients with type 2 diabetes (HbA1c 7.8±0.2% [62.1±2.3 mmol/mol]) and increased albumin-to-creatinine ratio (ACR) were (...)
• 02:00
  38-LB: Physical Activity and Glycemia among Young Adults with Type 1 Diabetes and Overweight or Obesity—Results from Advancing Care for Type 1 Diabetes and Obesity Network (ACT1ON) - MUNTIS FR, IGUDESMAN D, CRISTELLO A, et al. Diabetes
  The ACT1ON pilot study evaluated the feasibility of three dietary strategies to optimize weight and glycemic management among young adults with T1D and overweight or obesity. As a secondary measure, self-reported physical activity (PA) was collected at baseline, 3-, 6-, and 9-months from 68 (...)
• 02:00
  38-OR: Glycemic Control with Ultrarapid Lispro (URLi) vs. Lispro in Children and Adolescents with T1D: PRONTO-Peds - WADWA R, LAFFEL LM, FRANCO DR, et al. Diabetes
  This phase 3, treat-to-target study evaluated efficacy and safety of URLi vs. lispro in 716 pediatric patients (pts) with type 1 diabetes (T1D) . After 4-week lead-in to optimize basal insulin, pts were randomized to double-blind URLi (n=280) or lispro (n=298) injected 0-2 min prior to meals, (...)
• 02:00
  390-P: Adipose Insulin Resistance Relates to Perturbed Renal Hemodynamics in Obese Youth with and without Type 2 Diabetes - PLATNICK C, PRASAD PV, LI L, et al. Diabetes
  Our objective was to compare renal hemodynamic function between obese youth with and without type 2 diabetes (T2D) and relate these measures to adipose insulin resistance (IR) .We assessed insulin sensitivity and kidney function in obese youth with (n=31, 15.8 ± 1.8 years, BMI 35.6 ± 6.6 kg/m2) , (...)
• 02:00
  528-P: Provider Perspectives: Digital Apps in Delivering Diabetes Self-Management Education and Support (DSMES) - MEHROTRA N, KRALL JS, NG J, et al. Diabetes
  Introduction: DSMES is a critical component of diabetes (DM) care. Providers are expected to perform this service, but time for it is limited, especially for ongoing support. Digital tools, like mobile applications (apps) , show promise in extending efforts and supporting self-management, but (...)
• 02:00
  529-P: Impact of Medication Adherence (MA) to Oral Glycemic Agents (OHAs) on Initiation of Dialysis in Patients with Moderately Impaired Renal Function - YAGUCHI Y, FUJIHARA K, YAMADA MH, et al. Diabetes
  Although we showed a significant association of poor adherence to OHAs with start of dialysis, this relationship according to the estimated glomerular filtration rate (eGFR) was not clarified. Patients with eGFR 2 are at high risk for dialysis. To identify the impact of MA by eGFR categories, (...)
• 02:00
  52-LB: Adult’s Lived Experience Using the Insulin-Only Bionic Pancreas - GARZA KP, HOWARD KR, WEISSBERG-BENCHELL J, et al. Diabetes
  The Insulin-only Bionic Pancreas (BP) Pivotal Trial compared the BP initialized only with body weight vs. standard-of-care (SC) . The BP autonomously determines all insulin doses. Meals are announced without carbohydrate counting. For adults aged 19-75 the mean adjusted difference of HbA1c at (...)
• 02:00
  52-OR: The Burden of Food Insecurity on Quality of Life in Adults with Diabetes - WALKER RJ, THORGERSON A, MOSLEY-JOHNSON E, et al. Diabetes
  Food insecurity, or the lack of consistent access to enough food for an active, healthy life, is associated with worse glycemic control and higher mortality in adults with diabetes. However, little is known regarding the burden of food insecurity on health-related quality of life, a global (...)
• 02:00
  530-P: Complex Diabetes Management in Primary Care: Confidence and Opportunities for Specialty Support - MENDEZ CE, MATTOX EA, KADIYALA S, et al. Diabetes
  Access to specialized diabetes care is limited due to shortage of endocrinologists and distance to specialty clinics. In addition, referrals to out-of-network providers frequently results in suboptimal care coordination. Tele-mentoring models such as ECHO (Extension for Community Healthcare (...)
• 02:00
  531-P: Continuous Glucose Monitoring Placement during Physical Activity - THRASHER BJ, DYESS RJ, MCKAY TE, et al. Diabetes
  Objectives: Individuals living with type 1 diabetes (T1D) are encouraged to participate in physical activity (PA) . It is vital that technology used to manage diabetes, such as a continuous glucose monitor (CGM) , provides reliable results during and after exercise. Currently, the Dexcom G6 CGM (...)
• 02:00
  532-P: Voluntary Exercise during Food Restriction Promotes a Sustained Increase in Hepatic Oxidative Metabolism - DEJA S, KUCEJOVA B, MAURER A, et al. Diabetes
  Exercise is an important lifestyle intervention for the prevention and treatment of NAFLD. Importantly, exercise can reduce hepatic steatosis independent of changes in body mass, which may stem from increased oxidative demand in liver during exercise. Increased hepatic gluconeogenesis (GNG) and (...)
• 02:00
  533-P: A Ketogenic Diet Reduces Blood Glucose and Restores Exercise Training–Induced Improvements in Aerobic Capacity in Hyperglycemic Mice - NAVA RC, COONEY EM, LESSARD SJ. Diabetes
  Evidence suggests that hyperglycemia can blunt improvements in aerobic capacity (VO2peak) with exercise training. Accordingly, people with diabetes have lower VO2peak than normoglycemic controls, increasing their risk of complications and mortality. We hypothesized that reducing blood glucose (...)
• 02:00
  534-P: Sustained Improvement of Whole-Body Oxidative Capacity but Not Insulin Sensitivity after Detraining of People with Type 2 Diabetes - MASTROTOTARO L, APOSTOLOPOULOU M, SAATMANN N, et al. Diabetes
  High-intensity interval training (HIIT) improves skeletal muscle mitochondrial oxidative capacity in humans with different degrees of insulin sensitivity, whereas it increases insulin sensitivity along with number of circulating small extracellular vesicle (SEV) mainly in insulin resistant (...)
• 02:00
  535-P: The Effect of Starting Blood Glucose Levels on Electrolyte Balance During and After Exercise in Type 1 Diabetes - MOMENI Z, BOULÉ NG, PRADO C, et al. Diabetes
  ADA guidelines recommend that people with type 1 diabetes (PWT1D) start exercise with blood glucose (BG) levels of 7-mmol/L. Those fearing hypoglycemia often start higher, which may affect kidney function and electrolyte balance. We examined serum and urine electrolyte concentration during (...)
• 02:00
  536-P: Impact of Physical Activity (PA) and Macronutrient Intake on CGM Glucometrics in Youth with T1D - LA BANCA RO, VOLKENING LK, DASSAU E, et al. Diabetes
  Aim: Maintaining in-range glucose on days with PA is challenging for youth with T1D, often requiring fine-tuning of diet and insulin. We examined how PA and macronutrient intake impact glycemic outcomes in youth with T1D.Methods: Youth and parents completed 3-day PA and diet records and youth (...)
• 02:00
  537-P: Timing of Moderate-to-Vigorous Physical Activity Is Associated with Improvements in Glycemic Control in Type 2 Diabetes in the Look AHEAD Study - QIAN J, XIAO Q, WALKUP MP, et al. Diabetes
  Background: We examined the association of time-of-day bout-related moderate-to-vigorous physical activity (bMVPA) with changes in glycemic measures and use of antidiabetic medications in adults with type 2 diabetes.Methods: Look AHEAD participants were randomly assigned to a lifestyle (...)
• 02:00
  538-P: Effects of Exercise Timing on Glucometabolic Response in Patients with Type 2 Diabetes Mellitus: A Meta-analysis of Randomized Controlled Trials - FU Y, TANG X, QIN B, et al. Diabetes
  Background and purpose: Exercise is widely perceived to benefit glycemic control through remodeling metabolic pathways in patients with type 2 diabetes mellitus (T2DM) . Circadian clock-regulated metabolic pathways could be reprogrammed by dietary challenges, timing of exercise relevant to (...)
• 02:00
  539-P: Evaluation of a Comprehensive Physical Fitness Index to Predict Future Prediabetes and Metabolic Syndrome (MetS) - SATO T, FUJIHARA K, YAMADA MH, et al. Diabetes
  Muscle strength, balance, and flexibility has been associated with the development of type 2 diabetes and atherosclerosis, but little is known whether the physical score (PS) , which integrates these physical fitness indices, can predict future metabolic diseases. We investigated the (...)
• 02:00
  53-LB: Youth and Parents’ Experiences Using the Insulin-Only Bionic Pancreas - HOWARD KR, GARZA KP, FELDMAN M, et al. Diabetes
  The Insulin-only Bionic Pancreas (BP) Pivotal Trial compared the BP initialized only with body weight vs. standard-of-care (SC) . The BP autonomously determines all insulin doses. Meals are announced without carbohydrate counting. For youth aged 6-17 the mean adjusted difference of HbA1c at 13 (...)
• 02:00
  53-OR: Diabetes Stigma and Clinical Outcomes in Adolescents and Young Adults: The SEARCH for Diabetes in Youth Study - EITEL KB, ROBERTS AJ, DAGOSTINO R, et al. Diabetes
  We examined the association between diabetes stigma and glycemic control, treatment regimen, and acute and chronic complications in adolescents and young adults (AYAs) with type 1 (T1D) and type 2 diabetes (T2D) in the SEARCH for Diabetes in Youth Study, 2016-2019. A 5-question survey assessed (...)
• 02:00
  540-P: Meta-analysis of Blood Glucose Response to High Intensity Exercise in Adults with Type 1 Diabetes - MCCLURE R, WESEEN E, ALCÁNTARA CORDERO F, et al. Diabetes
  Background: High intensity exercise-induced hyperglycemia is recognized in T1D clinical guidelines, but its occurrence after high intensity intermittent exercise (HIIE) in acute studies is inconsistent. This meta-analysis aimed to examine the available evidence of BG responses to HIIE in adults (...)
• 02:00
  541-P: Patterns of Physical Activity and Cardiometabolic Risk in Hispanic/Latino Adults with or Vulnerable to Type 2 Diabetes - BEVIER WC, LAMUNION S, ROACH M, et al. Diabetes
  While physical activity (PA) improves physical health, and wearable accelerometers clarify PA behavior, patterns of PA and cardiometabolic risk have not been well studied in ethnic minorities. In the Mil Familias observational cohort study of Hispanic/Latino adults with or at risk for type 2 (...)
• 02:00
  783-P: When Automated Insulin Delivery Technology Meets Behavior: A Pilot Exploration of Human-Machine Coadaptation in Type 1 Diabetes - COLMEGNA P, MCFADDEN R, FABRIS C, et al. Diabetes
  Background: Automated Insulin Delivery (AID) devices in type 1 diabetes (T1D) are becoming standard of care, and the need for adaptive AID systems is now well recognized. However, very little is known about how self-treatment behaviors should be adapted to the action of an AID system, (...)
• 02:00
  784-P: An Insulin Infusion Set with Novel Kink-Free Flexible Cannula: In-Vitro/In-Vivo Studies - CHIU C, ZHANG G, CHATTARAJ S, et al. Diabetes
  Objective: The wear duration of insulin infusion sets (IIS) is impacted by initial local trauma caused by cannula insertion and sustained inflammation due mostly to insulin infusion, both of which affect insulin absorption. Efforts have been made to mitigate cannula kinking at insertion and (...)
• 02:00
  785-P: Comparison of Six Months Experience on Hybrid Closed Loop MiniMed 670G System and Advanced Hybrid Closed Loop MiniMed 780G System Using a Structured Initiation Protocol in Children and Adolescents with Type 1 Diabetes - PETROVSKI G, CAMPBELL J, ALKHALAF F, et al. Diabetes
  Background: The objective of this study was to evaluate glycemic outcomes using a structured initiation protocol for Hybrid Closed Loop (HCL) MiniMed 670G and Advanced Hybrid Closed Loop (AHCL) Minimed 780G system in children and adolescents with Type 1 Diabetes (T1D) previously treated with (...)
• 02:00
  786-P: Importance of Data Distribution on Deep Learning Model for Glucose Prediction - ROMERO-UGALDE HM, ADENIS A, DAUDET L, et al. Diabetes
  Objective: This paper analyses the glycemia distribution impact in a deep learning (DL) model for glucose forecast on T1D patients.Method: Data of 139 adult T1D patients equipped with DBLG1 System are used. Data of 70% of the patients is used for hyperoptimizing a DL model (hyperop set) and 30% (...)
• 02:00
  787-P: Quality of Life and Psychological Well-Being among Children with Diabetes Using Open-Source Automated Insulin Delivery Systems: Findings from a Global Survey - KNOLL C, BRAUNE K, BALLHAUSEN H, et al. Diabetes
  Background: Open-source automated insulin delivery (AID) systems have shown to be safe and effective in clinical and real-world studies and to increase quality of life (QoL) in adult users. However, there is a lack of evidence on the effect on health-related QoL and general wellbeing in (...)
• 02:00
  788-P: Development of an Extended-Wear Infusion Set with Angled Cannula - ZHANG G, ANSELMO E, ORTIGOZA JL, et al. Diabetes
  Objective: Medtronic Mio™ 30 infusion set (M30IS) is a single-use consumable for pump users with pre-loaded inserter, utilizing a 30° insertion angle, and labeled for 3-day use. The M30IS wear duration is impacted by initial local trauma caused by insertion & cannula and sustained (...)
• 02:00
  789-P: Evaluating the Feasibility of Incorporating Nonglucose Signals in Automated Insulin Delivery System - BANERJEE A, KAUR R, ZANILETTI I, et al. Diabetes
  Introduction: There is need to improve glucose control and QoL for type 1 diabetes (T1D) using automated insulin delivery (AID) . We evaluated non-glucose signals in subjects with T1D on AID using the multi-functional Empatica E4 device (E4) .Method: During a 2-week prospective AID study for 12 (...)
• 02:00
  78-LB: Association between Daytime vs. Nighttime Mean Glucose and Time-in-Range with A1C in Adults with Type 1 Diabetes - SHAH V, VIGERS TB, PYLE L, et al. Diabetes
  Prior studies using frequent self-monitored blood glucose in patients with type 2 diabetes on oral medications reported that the relative contribution of fasting glucose gradually increased with increasing HbA1c levels (30% for A1c 10.2%) . This has led to targeting fasting glucose first to (...)
• 02:00
  78-OR: LRH-1/NR5A2 Agonism Triggers an Anti-Inflammatory Phenotypic Switch of Immune Cells from Patients with Type 1 Diabetes and Improves Islet Engraftment/Function - COBO-VUILLEUMIER N, RODRIGUEZ-FERNANDEZ S, LORENZO PI, et al. Diabetes
  Administration of the LRH-1 agonist BL0refrains hyperglycemia in 3 mouse models of type 1 diabetes (T1DM) . This antidiabetes action correlated with beta cell mass preservation and the presence of anti, rather than pro, inflammatory immune cells, indicating tolerization. Herein, we sought to (...)
• 02:00
  790-P: Evaluating Psychological Stress Nonglucose Signal for Incorporation in Automated Insulin Delivery System - BANERJEE A, KAUR R, ZANILETTI I, et al. Diabetes
  Introduction: Psychological stress may adversely affect glucose control. However, the effect of stress on efficacy of automated insulin delivery (AID) in Type 1 Diabetes (T1D) is still unknown. We evaluated non-glucose signals in subjects with type 1 diabetes on AID using the Empatica E4 device (...)
• 02:00
  791-P: Clinical Data of a New Insulin Micropump System in Children with Type 1 Diabetes Mellitus (T1DM) - RISTA L, FLORES A, RIVERS M, et al. Diabetes
  Background: To maintain glucose control in T1DM is especially difficult in children that have unpredictable amounts of physical activity and broad eating patterns. Advances in diabetes technology include Continuous Subcutaneous Insulin Infusion (CSII) and patch/tubeless micropumps are newer (...)
• 02:00
  792-P: Evaluation of Long-Term Glycemic Outcomes by Ethnicity in Adults with Type 1 Diabetes Using Control-IQ Technology - GRAHAM R, SINGH H, MUELLER L, et al. Diabetes
  Despite increasing prevalence of T1D in ethnic minorities, they remain underrepresented in research studies evaluating diabetes technologies. Experiences of diverse cohorts are essential to assessing acceptability of diabetes devices. The Control-IQ Observational (CLIO) Study is an ongoing (...)
• 02:00
  793-P: Real-World Data of Four-Year Durability of Glycemia Control with V-Go - VADAKEKALAM J, COPPLE T, TRIGOSO WF. Diabetes
  Patients with diabetes may struggle to comply with numerous injections required for blood glucose control. Previous studies have shown subcutaneous insulin infusion devices, such as V-Go, are an effective alternative to injections despite the limitation of the total daily dose of insulin (TDD) (...)
• 02:00
  484-P: Uncoupling of IL-1beta and VEGF-A Signaling Axis Contributes to Impaired Arteriogenesis in the Context of Aging and Diabetes Mellitus - MANTSOUNGA CS, SHARMA S, LEE C, et al. Diabetes
  Peripheral artery disease (PAD) caused by atherosclerosis leads to considerable morbidity and mortality throughout the world, in large part, due to tissue damage from both acute and chronic occlusive ischemia. Preclinical studies have identified mechanisms involving bone marrow derived (...)
• 02:00
  485-P: DFUCare Deep-Learning–Based Mobile App for Diabetic Foot Ulcer Monitoring - SENDILRAJ V, PILCHER WC, BHASIN MK. Diabetes
  In 2021, 1 out of adults suffered from diabetes mellitus globally. A major complication resulting from this is diabetic foot ulcers (DFU) , which can lead to amputation if improperly managed. Current clinical approaches to DFU have significant limitations, such as the high cost involved in the (...)
• 02:00
  720-P: Change in Body Weight from Baseline with Tirzepatide: Sex Subgroup Analysis of the SURPASS Studies - PLAT AW, RASOULI N, PELESHOK J, et al. Diabetes
  Five Phase 3 SURPASS trials have shown robust efficacy of novel dual GIP/GLP-1 receptor agonist, tirzepatide, in glycaemic control and body weight (BW) loss in adults with Type 2 Diabetes (T2D) . A key secondary endpoint investigated the effect of tirzepatide (5, 10, and 15 mg) versus placebo (...)
• 02:00
  721-P: Insulin-Sparing Effects of Oral Semaglutide: An Analysis of PIONEER 8 - ARODA VR, ABILDLUND MT, AGESEN R, et al. Diabetes
  The PIONEER 8 (NCT03021187) trial demonstrated significant glucose-lowering efficacy of oral semaglutide vs. placebo (pbo) in patients (pts) with T2D inadequately controlled with insulin. Additionally, those assigned to oral semaglutide (7 or 14 mg daily) had a lower total daily insulin dose at (...)
• 02:00
  82-OR: Phase Angle of Bioelectrical Impedance Analysis Correlates with Multiple Parameters of Diabetic Polyneuropathy in Patients with Type 2 Diabetes - SCHIMPFLE L, MOOSHAGE C, TSILINGIRIS D, et al. Diabetes
  Background and Aims: Sensorimotor polyneuropathy (DPN) is the most common diabetic complication and a major contributor to increased morbidity and mortality in diabetic patients. With diagnostic methods still being limited, we aimed to correlate the phase angle (PhA) , a marker derived from (...)
• 02:00
  830-P: The Pan-PPAR Agonist Lanifibranor Improves Nonalcoholic Steatohepatitis (NASH) and Glycemic Control - COOREMAN MP, FRANCQUE S, DZEN L, et al. Diabetes
  Lanifibranor therapy resulted in both NASH resolution and fibrosis reduction in the phase 2b NATIVE study in patients with non-cirrhotic NASH, compared to placebo. PPAR signaling is involved in common pathways of NASH and type 2 diabetes (T2D) . We evaluated the association between the effect (...)
• 02:00
  933-P: Maternal Choices and Preferences for Screening Strategies of Gestational Diabetes Mellitus: A Discrete Choice Experiment - XU T. Diabetes
  Aims: This study aimed to investigate maternal preferences for gestational diabetes mellitus (GDM) screening options in China to identify an optimal GDM screening strategy.Methods: Pregnant women at 24?28 gestational weeks were recruited from Shandong province, China. A discrete choice (...)
• 02:00
  934-P: Real-World Evidence of Glucose Lowering Drug Use, Glycemic Outcomes, and Severe Hypoglycemia in Hong Kong: Eighteen-Year Trends in 0.9 Million Adults with Diabetes - YANG A, WU H, LAU EH, et al. Diabetes
  Introduction: Improvements in glycemic outcomes have stalled since 20in some international surveys. We examined the latest trends in drug use and glycemic outcomes following recent introduction of newer classes of glucose lowering drugs (GLDs) in a territory-wide analysis.Methods: Using data (...)
• 02:00
  935-P: Impact of Social Determinants of Health (SDoH) on Participation in a Remote Monitoring Diabetes Program (RDMP) to Improve Glycemic Control - KOMPALA T, LU W, PAINTER SL, et al. Diabetes
  Introduction: Socioeconomic and educational status impact diabetes self-management and are believed to affect utilization of digital health programs, which could widen healthcare disparities. The objective of this study was to examine SDoH within members of Livongo for Diabetes, a RDMP, and (...)
• 02:00
  936-P: Improving Decision Making by Clinicians for Initiation of Insulin in Adults with Type 2 Diabetes Using Simple Python Program - LAKHANI OJ. Diabetes
  Introduction: The initiation of insulin is significantly delayed in patients with type 2 diabetes. To facilitate primary care doctors for decision making we have written a simple computer program using Python.Methods: The program incorporates evidence based recommendations for insulin (...)
• 02:00
  937-P: Multicenter application of EFR (Endocrine Final Recommendation) Note Embedded in EMR Improves the Accuracy of Diabetes Discharge Regimen in Hospitalized Patients with Diabetes - LLOYD J, ABDULWAHID T, LEVIN J, et al. Diabetes
  Patients with diabetes who are hospitalized often have changes in diabetes treatment regimen during hospitalization. In the ReCoDED study done at our institution, it was found that discharge instructions provided by Endocrine teams were not always accurately translated into discharge (...)
• 02:00
  938-P: Implementation of Psychosocial Screening in the Type 1 Diabetes Exchange Quality Improvement (T1DX-QI) Network - CORATHERS S, OSPELT EL, ROMPICHERLA S, et al. Diabetes
  T1DX-QI is a network of over 40 pediatric and adult centers that share best practices to improve outcomes for people with T1D. Guidelines for comprehensive diabetes care recommend integration of psychosocial screening; however, variable resources and clinical structures influence the degree to (...)
• 02:00
  93-LB: A Randomized Clinical Trial of Safety, Pharmacokinetics, and Pharmacodynamics of Weekly Dosing Supagutide in Healthy Chinese Subjects - MA A, ZHOU Y, LOU Y, et al. Diabetes
  Supaglutide (Supa) is a novel once-weekly, human-derived long-acting GLP-1 analogue developed for patients with type 2 diabetes. In this study, we investigated the safety, pharmacokinetics (PK) , pharmacodynamics (PD) and potential immunogenicity of single-dose subcutaneous injections of Supa (...)
• 02:00
  940-P: Personalized Diabetes Care Reduces Distress and Improves Treatment Satisfaction in Patients with Breast Cancer - HARROD J, CHEUNG YM, FOWLER KM, et al. Diabetes
  In patients with breast cancer (BCa) and diabetes (DM) , diabetes distress (DD) and treatment satisfaction (DTS) can influence cancer management and outcomes, yet there is limited data on how important these factors are in the BCa DM population. In this pilot study we assessed the impact of (...)
• 02:00
  941-P: Impact of Whatsapp-Based Monitoring on Glycemic Control and Exercise Habits in Patients with Diabetes in Indian Population - SABOO B, SHRIVASTAVA A, TEWARI A, et al. Diabetes
  Introduction: Diabetes treatment requires the involvement of people with diabetes in the form of regular exercise and lifestyle measures. Exercise is an important strategy in the management of diabetes. Regular exercise is necessary for good Glycaemic control and Metabolic health. Newer methods (...)
• 02:00
  942-P: Disparities in Telemedicine Use among Pediatric Patients with Type 1 and Type 2 Diabetes - CHAN K, DEMETERCO-BERGGREN C. Diabetes
  Despite the increase in telehealth services in diabetes care during the COVID-pandemic, studies have found disparities in telemedicine (TM) use among patients. Our Diabetes Clinic currently cares for 1400 patients with type 1 diabetes (T1D) with 46% being publicly insured and for 375 patients (...)
• 02:00
  1072-P: Diabetes Mellitus and Risk of Breast Cancer: A Large-Scale, Prospective, Population-Based Cohort Study - XIONG F, WANG J, NIERENBERG JL, et al. Diabetes
  Background: A previous meta-analysis identified a weak association between diabetes and breast cancer (BCa) risk among postmenopausal women. The heterogeneity among studies, however, was substantial, and many of the included studies were susceptible to residual confounding by body mass index (...)
• 02:00
  1101-P: Cardiovascular Risk Factors and Intraoperative Hypotension Predicted Development of Insulin Deficiency and Diabetes after Pancreatectomy - MOON S, LEE J, SOHN H, et al. Diabetes
  Objective: Ischemia in pancreatic islets is critical to beta cell function, however, clinical evidences on the implications for diabetes are lacking. Pancreatectomy can induce diabetes, but the mechanisms are not clearly elucidated. Therefore, we examined if cardiovascular disease (CVD) risk (...)
• 02:00
  1102-P: Identifying Blood Biomarkers for Type 2 Diabetes Subtyping: A Report from the ORIGIN Trial - PIGEYRE M, GERSTEIN HC, GROOP L, et al. Diabetes
  Diabetes (DM) can be classified into 5 subtypes characterized by distinct progression in dysglycaemia and complications. Using 5 clinical variables, we categorized 7017 participants from the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial into 1/auto-immune DM (n=241) , (...)
• 02:00
  1104-P: Prevalence and Clinical Determinants of Nonalcoholic Fatty Liver Disease by Liver Scores in Adults with T1DM - LUNDHOLM MD, BENA JF, ZHOU K, et al. Diabetes
  NAFLD is common in diabetes, however the prevalence and clinical features of NAFLD in T1DM are not well defined.A retrospective, unicenter, cross-sectional analysis was performed of adults with T1DM at our institution from 2015-2018. The hepatic steatosis index (HSI) , Framingham steatosis (...)
• 02:00
  1105-P: Moderate-to-Advanced Liver Fibrosis Is Common in Patients with Type 1 Diabetes (T1D) and Nonalcoholic Fatty Liver Disease (NAFLD) - TOMAH S, SALAH T, AL-BADRI M, et al. Diabetes
  ADA guidelines recommend screening for significant fibrosis in patients with type 2 diabetes and steatosis or elevated ALT. In contrast, there are limited or inconsistent data about the prevalence of NAFLD and liver fibrosis in patients with type 1 diabetes (T1D) . We screened patients with T1D (...)
• 02:00
  1173-P: Metabolomic Signatures of Refined Grains Intake and Risk of Gestational Diabetes - ZHU Y, ZHENG S, NGO A, et al. Diabetes
  Previous studies linked refined grains intake to risk of gestational diabetes (GDM) ; however, the underlying mechanisms remain understudied. We aimed to identify and validate refined grains-related metabolites as biomarkers for GDM. In a nested case-control study of 91 women with GDM and 180 (...)
• 02:00
  1174-P: A Posteriori Dietary Patterns and Insulin-Resistance Status and Diabetes Risk by Hispanic/Latino Heritage in HCHS/SOL - MALDONADO LE, SOTRES-ALVAREZ D, MATTEI J, et al. Diabetes
  We examined links among dietary patterns (DPs) , insulin resistance (IR) , and diabetes risk by heritage (Cuban, Dominican, Mexican, Puerto Rican, and Central and South American) in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) . HCHS/SOL is a population-based cohort of 16,415 (...)
• 02:00
  1208-P: Age-Specific Association between Risk Factors and All-Cause and Cause-Specific Mortality in People with Type 2 Diabetes - WU H, LAU EH, YANG A, et al. Diabetes
  Background: We aimed to examine age-specific association and population attributable fraction (PAF) of risk factors for all-cause and cause-specific mortality in people with type 2 diabetes.Methods: We used data from 360,202 people with type 2 diabetes who underwent metabolic assessment in (...)
• 02:00
  127-LB: Real-World A1C Changes and Prescribing Provider Types among T2DM Patients Initiating Treatment with Oral Semaglutide - FRAZER MS, SWIFT C, LESZKO M, et al. Diabetes
  Purpose: To describe A1c changes and characteristics of patients with type 2 diabetes mellitus (T2DM) initiating oral semaglutide (sema) , by baseline A1c ?9% and DisclosureM. S. Frazer: None. C. Swift: Employee; Novo Nordisk. M. Leszko: None. A. Sargent: None. E. Buysman: None. S. B. Alvarez: (...)
• 02:00
  127-OR: Diabetic Foot Ulcers in Remission: Cyclical-Pressure Topical Wound Oxygen Therapy Significantly Reduces DFU Related Hospitalizations and Amputations over a 12-Month Period - GAROUFALIS MG. Diabetes
  Purpose: The purpose of this real-world evidence (RWE) cohort study was to evaluate whether utilization of Cyclical-Pressure Topical Wound Oxygen (TWO2) therapy had any impact on the incidence of Diabetic Foot Ulcer (DFU) related hospitalizations and amputations over a 12-month period in (...)
• 02:00
  1280-P: Use of Machine Learning to Determine the Relative Influence (RI) of Genetic Risk Scores of Glycemic Traits on Myocardial Infarction and Stroke in 409,633 Participants in the UK Biobank - DESHMUKH H, MILES M, BHAIJI A, et al. Diabetes
  Introduction: Genome-wide association studies have identified numerous glycemic traits-associated SNPs with myocardial infarction (MI) and stroke. However, conventional regression methods combining these large numbers of highly significant SNPs in a weighted genetic risk score (wGRS) have only (...)
• 02:00
  1281-P: Understanding the Interaction between Type 2 Diabetes and COVID-via Extracellular Vesicle Proteomic and Phosphoproteomic Signatures - NUNEZ LOPEZ YO, ILIUK A, CASU A, et al. Diabetes
  Evidence supporting the involvement of EVs in the pathogenesis/severity of SARS-CoV-2 infection is starting to accumulate. However, little is known about their specific associations in the context of COVID-and type 2 diabetes interaction. Our study included 48 plasma samples (N=12/group) (...)
• 02:00
  1335-P: Deciphering Liver Glycome Regulation by the PGC-1/FN3K Axis - SAAR E, DAIME YG, TIROSH A, et al. Diabetes
  Diabetes in general, and specifically in the context of obesity, is characterized by hyperglycemia resulting in non-enzymatic glycation of proteins, a key event in the pathophysiology of diabetes and its chronic complications. Yet, the full scope of molecular targets for glycation, particularly (...)
• 02:00
  1336-P: FoxO1-ATGL-Sirt1-FoxO1 Feed Forward Signaling Mediates Effects on Hepatic Gene Expression and Glucose Homeostasis in LIRKO Mice - O-SULLIVAN I, BHATTACHARYYA S, LIEW C, et al. Diabetes
  FoxO1 is a major target of insulin action and regulates expression of ATGL and its inhibitor, G0S2, in the liver (Cell Rep 15:349, 2016) . Here, we asked whether ATGL mediates effects of FoxO1 in liver-specific insulin receptor knockout (LIRKO) mice. Studies in LIRKO and IR/FoxO1 double (...)
• 02:00
  1337-P: Sex-Specific Variation in Lipid Metabolism in Response to Nutritional Stress Is Associated with Differences in NASH Progression - MOON M, MURALI A, BELLO F, et al. Diabetes
  Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the US, encompassing a disease spectrum defined by steatosis, inflammation (NASH) , and fibrosis. Although the incidence of NASH is less in women compared with men, the mechanistic basis for this (...)
• 02:00
  1338-P: Glucoregulatory Disturbances in Autoimmune Liver Disease and Nonalcoholic Fatty Liver Disease Compared with Healthy Individuals - JENSEN AH, YTTING H, GRANDT J, et al. Diabetes
  Gluco-regulatory disturbances such as hepatic insulin resistance, hyperinsulinemia and prediabetes are commonly present in patients with nonalcoholic fatty liver disease (NAFLD) and those individuals may over time develop full-blown type 2 diabetes. Chronic liver diseases­ such as NAFLD and (...)
• 02:00
  1376-P: Comparison of a-Cell Response to Intravenous or Oral Glucose in Nondiabetic Humans - LAURENTI MC, MANDUCA A, COBELLI C, et al. Diabetes
  Type 2 Diabetes (T2DM) and prediabetes are characterized by ?-cell and ?-cell dysfunction which can occur independently. Defects in ?-cell response to rising glucose can be evaluated with an oral or intravenous challenge: the former reflects normal physiology, the latter is unaffected by incretins (...)
• 02:00
  1377-P: Pramlintide Lowers Postprandial Glucagon Concentrations by Inhibiting Glucagon Secretion without Altering Clearance in Type 1 Diabetes: A [13C15N]-Glucagon Study - RUCHI F, ROMERES D, SCHIAVON M, et al. Diabetes
  To determine the underlying mechanism of pramlintide effects on postprandial (PP) glucagon concentrations, we studied thirteen C-peptide negative T1D subjects (Age 35±yrs, BMI 27.6±2.2 kg/m2, fasting plasma glucose 9.4±4 mM, HbA1c 7.1±1%) on two occasions in random order, with and without 30 ?g of (...)
• 02:00
  1378-P: Chronic Sleep Deprivation Impaired Bone Formation in Growing Rats and Downregulated PI3K/AKT Signaling in Bone Tissues - DUAN X, GUO L. Diabetes
  Background: Sleep deprivation (SD) , recognized as a public health epidemic, impaired glucose metabolism, yet little is known about the association between sleep and bone health.Methods: Twenty 5-week-old male Wistar rats and randomly divided into the CSD and normal control (NC) groups after (...)
• 02:00
  1379-P: Combination of FGF21 and ß3-Adrenergic Treatment in Obese Mice - ZOUHAR P. Diabetes
  An induction of lipolysis by ?3-adrenergic agonist CL316,243 (CL) increases plasma free fatty acid (FFA) level resulting later in ectopic lipid accumulation in liver. The peak of FFA stimulates insulin secretion and causes acute drop of blood glucose (BG) in chow-fed mice. This glucose-lowering (...)
• 02:00
  137-LB: Unmet Social Needs and Uptake of Recommended Diabetes Processes of Care in a High-Need, High-Cost Medicaid Population - DURU O, KLOMHAUS AM, MANGIONE C, et al. Diabetes
  Diabetes patients with unmet social needs (e.g., housing instability, food insecurity) may be less able to complete recommended processes of care than patients without these challenges. We examined survey data from a multi-state sample of Medicaid patients with diabetes (n=6,087) identified by (...)
• 02:00
  137-OR: A Genetic Approach to Detangling the Heterogeneity of Fasting Insulin Levels - SEVILLA M, GOODARZI MO, DICORPO DA, et al. Diabetes
  Fasting insulin (FI) is a heterogeneous trait with high variability between individuals and populations. Increased FI is associated with an increased risk of type 2 diabetes (T2D) and its complications, including coronary artery disease (CAD) and hypertension (HTN) . We hypothesize that we (...)
• 02:00
  145-OR: Selenite Treatment Impacts Adipocyte Metabolism and Counteracts Detrimental Effects of Diet-Induced Insulin Resistance - HAUFFE R, RATH M, KLEINRIDDERS A. Diabetes
  The loss of insulin receptor (IR) in white adipose tissue (WAT) is a feature of type 2 diabetes. Previously, we have demonstrated that feeding mice a preventive selenium rich HFD (SRHFD) , while not influencing obesity development, counteracted diet-induced downregulation of IR and insulin (...)
• 02:00
  1460-P: Tauroursodeoxycholic Acid (tudca) Improves the Morphofunction of Pancreatic Beta Cells in Postweaning Protein-Restricted Mice - SANTOS L, ARAUJO T, ALVES BL, et al. Diabetes
  Protein restriction in the postweaning diet in mice impairs glucose metabolism by reducing insulin secretion from pancreatic ? cells. TUDCA in obese rodents and humans normalized insulin secretion, increased insulin clearance, furthermore recovered mass and the number of ? cells per islet in (...)
• 02:00
  1461-P: Quantifying Proinsulin Misfolding in the Endoplasmic Reticulum - ARUNAGIRI A, ALAM M, HAATAJA L, et al. Diabetes
  We recently reported that normal pancreatic islets or beta cell lines contain a subset of proinsulin molecules that have not achieved the three intramolecular disulfide bonds required for native insulin structure. Indeed, we found that non-native proinsulin monomers can form intermolecular (...)
• 02:00
  1462-P: Effect of Energy Restriction on the Intracellular Metabolism of Rodent Pancreatic ß-Cells In Vitro and Obese Mice - CHIBA K, NOMOTO H, IZUMIHARA R, et al. Diabetes
  Background: In pancreatic ?-cells under diabetic conditions, metabolic stressors cause mitochondrial dysfunction and reduce oxidative phosphorylation, resulting in impaired intracellular metabolism. It has been suggested that aberrant activation of (...)
• 02:00
  1463-P: Steroidogenic Factor 1 in ß cells Moonlights as a Brake on Glucose Intolerance in Obesity - GUO Y, LIU L, LI Y. Diabetes
  Pancreatic ? cells compensate with intense insulin secretion in obese individuals, failure of which marks a vital step in progression to type 2 diabetes (T2DM) . Steroidogenic factor-1 (SF-1) is a nuclear receptor which also locates in non-steroidogenic tissues and participates in metabolic (...)
• 02:00
  1464-P: Computational Modeling for Design of Next Generation Microphysiological Systems for Evaluation of ß-Cell Health and Function - VANDERLAAN E, TEPOLE A, HARBIN SL. Diabetes
  Dynamic insulin secretion is a key focus of ? cell research, with microfluidic devices emerging as a potential means to effectively evaluate this performance parameter in vitro. However, most devices maintain isolated islets in suspension despite evidence that collagen-islet interactions are (...)
• 02:00
  1465-P: Metabolic Remodeling in Pancreatic Beta Cells in Japanese Patients with Type 2 Diabetes - IZUMIHARA R, NOMOTO H, CHIBA K, et al. Diabetes
  Background and Aims: It has been shown that metabolic remodeling from oxidative phosphorylation to glycolysis via activation of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) occurs in pancreatic beta cells in non-Asians with diabetes, resulting in impaired beta cell function. (...)
• 02:00
  217-LB: Hepatic Mig6 Ablation Restores Glucose Homeostasis during Diet-Induced Obesity and Aging - IRIMIA-DOMINGUEZ JM, BLOOM-SALDANA EA, FUEGER PT. Diabetes
  Hepatic epidermal growth factor receptor (EGFR) expression and activation are decreased during steatosis in humans and animal models of obesity. Restoring EGFR activation in obesity-induced endoplasmic reticulum (ER) stress and diabetes is a potential therapy to improve liver function and (...)
• 02:00
  217-OR: A Randomized Controlled Trial Comparing the Safety and Efficacy of IDegLira vs. Basal Bolus in Patients with Poorly Controlled Type 2 Diabetes and Very High HbA1c (>9%–15%) : IDegLira HIGH Trial - GALINDO RJ, MOAZZAMI B, SCIOSCIA MF, et al. Diabetes
  IDegLira-HIGH trial was a non-inferiority, prospective, randomized clinical trial, comparing the efficacy and safety of insulin degludec/liraglutide combination (IDegLira) and a regimen of multiple daily injections (MDI) with basal-bolus insulin (BB) in adults (>18-80 years of age) , with type (...)
• 02:00
  218-LB: Remission of Type 2 Diabetes after Weight Loss in "Normal" Weight People—The ReTUNE Study - TAYLOR R, IRVINE KM, BARNES AC, et al. Diabetes
  Background and aims: Mechanisms underlying weight loss induced remission of type 2 diabetes (T2DM) have been reported only in people with BMI >27kg/m2. The Personal Fat Threshold hypothesis postulated that the same mechanisms in people with BMI 2. Pathophysiology during stepwise dietary weight (...)
• 02:00
  218-OR: The Effect of Insulin Degludec vs. Insulin Glargine U100 on Continuous Glucose Monitoring (CGM) Recorded Glycemic Metrics in People with Type 1 Diabetes and Recurrent Nocturnal Severe Hypoglycemia - BRØSEN JM, AGESEN R, ALIBEGOVIC A, et al. Diabetes
  Background and Aims: Insulin Degludec (IDeg) , in comparison with Insulin Glargine U100 (IGla) , reduces the risk of hypoglycemic events in people with type 1 diabetes (T1D) . The impact on CGM assessed glycemic metrics: the coefficient of variation (CV) , time in range (TIR) , time below range (...)
• 02:00
  219-LB: The Mitochondrial Calcium Uniporter Regulates Hepatic Lipid Accumulation and Mitochondrial Oxidation - LAMOIA TE, HUBBARD BT, GUERRA M, et al. Diabetes
  The mitochondrial calcium uniporter (MCU) facilitates mitochondrial calcium influx, and several enzymes that catalyze key steps of the tricarboxylic acid (TCA) cycle require calcium for their activation. As such, it is generally accepted that rates of mitochondrial oxidation correlate with (...)
• 02:00
  219-OR: Intranasal Insulin Enhanced Resting-State Functional Connectivity of Medio-Prefrontal Cortex in Type 2 Diabetes: A Substudy of the Memory Advancement with Type 2 Diabetes (MemAID) Randomized Control Trial - ZHANG Z, NOVAK V, NOVAK P, et al. Diabetes
  Type 2 diabetes mellitus (T2DM) is associated with impairment of resting-state functional connectivity (rsFC) and cognition. Intranasal insulin (INI) has emerged as potential treatment for T2DM-related cognitive decline. INI treatment has increased perfusion and low-frequency fluctuations in (...)
• 02:00
  21-LB: Transdermal Microneedle Device Delivery of Adipocyte-Specific AAVs to Overexpress Adipose Tissue Neurotrophic Factors in the Treatment of Diabetic Peripheral Neuropathy - BLASZKIEWICZ M, TOWNSEND KL. Diabetes
  Diabetes is the leading cause of peripheral neuropathy (PN) , which results in loss of nerve supply in tissues like skin, adipose and muscle. While there are currently few treatments for PN, early mitigation in the pre-diabetic state with tissue neurotrophic factors may improve nerve function (...)
• 02:00
  21-OR: Optimization of Albuminuria Lowering Treatment by Crossover Rotation to Four Different Drug Classes - CUROVIC V, KROONEN MA, JONGS N, et al. Diabetes
  Introduction: Renin-angiotensin system (RAS) inhibitors decrease urinary albumin:creatinine ratio (UACR) and are guideline recommended drugs for kidney protection but are ineffective in lowering UACR in up to 40% of cases. We hypothesized that rotation to another drug class overcomes resistance (...)
• 02:00
  220-OR: Characteristics Associated with Adding Insulin in Type 2 Diabetes in the Glycemia Reduction Approaches in Diabetes (GRADE) Study - MARTIN C, HOLLANDER PA, KRAUSE-STEINRAUF H, et al. Diabetes
  Delaying insulin when indicated in type 2 diabetes (T2D) prolongs exposure to hyperglycemia. In the GRADE study, adults (N=5047) with T2D (duration 7.5%. Written consent included acceptance of injectable medications, including insulin, and to add or intensify insulin therapy after outcome (...)
• 02:00
  221-LB: Normalisation of Glycemic and Extraglycemic Parameters with T2DM Remission—Insights from RCT Enabled by Whole-Body Digital Twin Technology - SHAMANNA P, SHAH L, MOHAMED M, et al. Diabetes
  We analyzed the efficacy of Twin Precision Treatment (TPT) : a novel whole-body digital twin enabled precision nutrition that measures weight, physical activity, sleep, and sensor glucose values, for achieving remission, at six months among 199 people with T2D enrolled in RCT. The mean age was (...)
• 02:00
  221-OR: Safety and Effectiveness of Insulin Aspart vs. Other Bolus Insulins in Women with Preexisting Type 1 Diabetes during Pregnancy: A Post Hoc Analysis of the EVOLVE Study - MATHIESEN E, ALIBEGOVIC A, ANIL G, et al. Diabetes
  Aims: This post hoc analysis of the real-world EVOLVE study investigated safety and effectiveness of insulin aspart (IAsp) vs. other bolus insulins in pregnant women with pre-existing type 1 diabetes.Methods: Maternal, pregnancy and infant outcomes were assessed in women receiving bolus (...)
• 02:00
  222-LB: Switching Palmitoyl and Oleoyl Position in Sn-2 and Sn-3 of a Triacylglycerol Led to Differential Body Weight Gain Rates and Hepatic Gene Expressions in Mice Fed a High-Fat Diet - HU X, WANG T, CHEN G. Diabetes
  Alterations of fatty acid metabolism have been associated with diabetes. Triacylglycerol (TAG) can be obtained from dietary sources and synthesized de novo. The composition and location of the fatty acyl groups in a TAG can affect its physicochemical features such as melting temperature, and (...)
• 02:00
  222-OR: Effectiveness, Safety, and Treatment Adherence of Follow-On Insulin in Diabetes Management - CHEN X, PHAM T, BARRON JJ, et al. Diabetes
  Background: The high insulin costs have associated with underuse and poor adherence among patients with types 2 diabetes (T2D) . Basaglar was approved by FDA in 2015 as a follow-on insulin to reference insulin Lantus. It presents an opportunity to reduce costs and improve adherence to insulin (...)
• 02:00
  223-LB: Interactive Effects of Dietary Iron and Chronic Hypoxia on Glucose Homeostasis in a T2D Mouse Model - HARRISON AV, MCCLAIN DA, SINK ST, et al. Diabetes
  The micronutrient iron is a risk factor for type II diabetes (T2D) . The effects of iron are, in part, mediated by the iron-sensing hypoxia inducible factor (HIF) pathway. The interactions of iron and hypoxia in the progression of T2D are not fully understood. Mice were fed a fast-food (FF) (...)
• 02:00
  223-OR: ADA Presidents' Select Abstract: Novel Ligand and Kinase-Independent Signaling by the Insulin Receptor - NAGAO H, CAI W, PAN H, et al. Diabetes
  Insulin acts through the insulin receptor (IR) tyrosine kinase and two major canonical post-receptor signaling pathways (the IRS-1/PI3K/Akt pathway and the Shc/Ras/MAP kinase pathway) to exert its classic metabolic and mitogenic actions. To create a detailed map of how different domains of the (...)
• 02:00
  246-LB: Neonatal Microbes Stimulate Beta-Cell Development - HILL JH, GUILLEMIN K, MURTAUGH CL, et al. Diabetes
  Newborns are exposed to environmental microbes that colonize the gut and increase in diversity during childhood to establish the resident microbiota. Concurrently, insulin-producing ?-cells enter a postnatal window of proliferation and maturation. We found that germ-free animal models exhibit (...)
• 02:00
  405-P: Glycemic Control Impacts Renal Function Decline among People with Type 1 Diabetes after the Onset of Diabetic Kidney Disease - SHAH H, MCGILL JB, HIRSCH IB, et al. Diabetes
  While poor glycemic control increases the risk of diabetic kidney disease (DKD) , its impact on renal function decline among those with established DKD is unclear. To examine this, we tested the relationship between baseline HbA1c and renal outcomes in the 3-year Preventing Early Renal Loss (...)
• 02:00
  46-LB: A New Approach to Understand Diabetes Burnout—Examining Potential Burnout Profiles? - ABDOLI S, MILLER KL, HESSLER DM. Diabetes
  Aim: The study aimed to identify latent profiles of diabetes burnout and examine if there are significant differences in psychosocial well-being, diabetes outcomes, and demographic characteristics between individuals with varying burnout profiles.Methods: A national sample of adults with T1D (...)
• 02:00
  46-OR: Differential Effects of RBP3 and Anti-VEGF on Retinal Dysfunctions in Diabetic Retinopathy - LI Q, ONIZUKA S, PARK K, et al. Diabetes
  Background: Anti-vascular endothelial growth factor (anti-VEGF) therapy has revolutionized the treatment of severe diabetic retinopathy (DR) , but significant subset of patients showed inadequate response to anti-VEGF. We have previously reported that retinol binding protein 3 (RBP3) prevented (...)
• 02:00
  470-P: Mitochondrial Long Noncoding RNA and the Compromised Electron Transport Chain Machinery in Diabetic Retinopathy - KOWLURU R, MOHAMMAD G, KUMAR J. Diabetes
  Purpose: Diabetic retinopathy has a complex pathogenesis, and mitochondrial damage is considered to play a central role. Diabetes dysfunctions the mitochondria and damages their DNA (mtDNA) , decreasing the transcription of mtDNA-encoded genes including Cytochrome B (CYTB) , which is important (...)
• 02:00
  471-P: Glycated Haemoglobin in the First Year after Diagnosis of Type 1 Diabetes Is an Independent Risk Factor for Diabetic Retinopathy: The IMDIAB 25 Years Follow-Up Study - MADDALONI E, CARLONE A, PITOCCO D, et al. Diabetes
  Background: Intensive glycemic control reduces the risk of diabetic retinopathy (DR) in people with type 1 diabetes (T1D) . However, the impact of glycemic control during the peri-diagnostic period on the long-term risk of DR is not known.Aim: To evaluate the association between the glycemic (...)
• 02:00
  675-P: DiabetesWise.org: An Innovative and Equitable Approach to Promote Diabetes Device Uptake - WONG JJ, HANES S, NELMES S, et al. Diabetes
  Aim: To identify correlates of device uptake in people with insulin-requiring diabetes before and after interacting with DiabetesWise.org, a free, unbranded online resource.Methods: The sample included 458 participants (Mage=37.1, SD=9.73; 66% female; 81% type 1) with minimal diabetes device (...)
• 02:00
  976-P: Measuring Engagement in a National Quality Improvement Collaborative (T1DX-QI) - OSPELT EL, MUNGMODE A, RIOLES N, et al. Diabetes
  Background: The T1D Exchange Quality Improvement Collaborative (T1DX-QI) is a national quality improvement network focused on improving health outcomes for patients with diabetes by sharing and using data to refine best practices among 41 participating clinics. Due to Covid-restrictions, (...)
• 02:00
  977-P: Utilization of Glucose Management Team–Conducted Remote Patient Visits Decreases Hospital Readmissions for Patients with Diabetes - JOHNS A, PRICE CE, ALOI JA, et al. Diabetes
  Introduction: Hospital readmissions are more common in persons admitted with diabetes as a primary diagnosis, accounting for approximately 20% of unplanned readmissions.1 Poor clinical outcomes and higher costs result.2 Helping people remain out of the hospital with improved diabetes (...)
• 02:00
  978-P: Rare Variants in Melanocortin 4 Receptor Gene (MC4R) Are Associated with Increased Visceral Fat and Altered Glucose Metabolism Independent of the Effect of Obesity in Children - GALUPPO B, MANNAM P, TRICO D, et al. Diabetes
  Melanocortin 4 receptor gene (MC4R) mutations result in early-onset obesity, but it is unclear how they affect abdominal fat distribution, intrahepatic fat, and related metabolic sequelae. 484 overweight/obese (BMI >85th percentile for age, sex, and height) youth (6-21 years) were screened for (...)
• 02:00
  979-P: Risk Factors for Hyperosmolar Hyperglycemic State in Youth-Onset Type 2 Diabetes - EVERETT EM, WISK LE, CHAO L. Diabetes
  Background: The prevalence of youth-onset type 2 diabetes (T2D) has been rising. There is a paucity of data on the risk factors for hyperosmolar hyperglycemic state (HHS) compared to diabetic ketoacidosis (DKA) in this population.Methods: We used the national Kids’ Inpatient Database to identify (...)
• 02:00
  97-LB: The DERMIS Study—Preliminary Evaluation of Skin Changes at Continuous Subcutaneous Insulin Infusion (CSII) Sites in Type 1 Diabetes (T1D) - BARAN JD, KHAKPOUR D, KALUS A, et al. Diabetes
  Background: CSII is used with increased frequency; however, there are no studies evaluating human skin histology related to its use. Objectives: 1) to investigate the skin histology and metabolite changes at CSII sites and 2) associate possible changes with clinical characteristics in a cohort (...)
• 02:00
  97-OR: Fatty Liver Index (FLI) Is an Independent Risk Factor for All-Cause Mortality and Cardiovascular Events in Type 1 Diabetes (T1D) : A 10-Year Observational Study - GAROFOLO M, LUCCHESI D, GUALDANI E, et al. Diabetes
  Nonalcoholic fatty liver disease (NAFLD) increases overall and CVD mortality. We prospectively observed 774 T1D to assess impact of FLI (based on BMI, waist, GGT and triglycerides) on all-cause death and CVD (MI, stroke, amputation, revascularizations) risk. Over a 11-year follow-up, 57 (...)
• 02:00
  980-P: Continuous Glucose Monitor Improves Glycemic Control in Youth-Onset Type 2 Diabetes - CHANG NT, SMITH J, CHAO L. Diabetes
  Background: Youth with type 2 diabetes (T2D) develop early treatment failure. Most patients do not self-monitor blood glucose (SMBG) levels at recommended frequency. Continuous glucose monitor (CGM) has been shown to improve glycemic control in pediatric T1D and adult T2D. Its feasibility and (...)
• 02:00
  981-P: Gut Microbiome Profile of American Indian Children with Obesity and Comparison with Industrialized and Preindustrialized Microbiomes - KOSTIC A, HANSON RL, SINHA M. Diabetes
  Gut microbial composition is associated with metabolic risk and differs markedly between industrialized (IND) and non-industrialized (non-IND) populations.Objective: To characterize the gut microbiome of American Indian (AI) children with overweight/obesity relative to IND and non-IND (...)
• 02:00
  982-P: Perfect Storm in Mississippi: High Rate of Obesity Leading to Surge in Pediatric Diabetes during the COVID-Pandemic - DIXIT N, PASHA S, SUKUMARAN AP, et al. Diabetes
  Background: Mississippi ranks second for childhood obesity prevalence (22%) above the national average of 16 % with significant racial and health disparities. Since March 2020, stay-at home orders, virtual learning, stress, and poor lifestyle may have provided a perfect setup leading to new (...)
• 02:00
  975-P: Simplifying Therapy to Assure Glycemic Control and Engagement (STAGE) for Patients with Clinic Refractory Diabetes - ALEXOPOULOS A, SOLIMAN D, LEWINSKI A, et al. Diabetes
  Patients with type 2 diabetes (T2D) who maintain poor glycemic control despite use of complex insulin regimens may not benefit from this costly and burdensome treatment approach. In a 16-week feasibility pilot, we proactively simplified the insulin regimens of patients with clinic refractory (...)
• 02:00
  105-OR: Microbiome-Derived Metabolite Signatures in Early- to Midpregnancy for Risk of Gestational Diabetes (GDM) - ZHU Y, SUSARLA S, BARUPAL D, et al. Diabetes
  Pre-diagnostic disturbances in gut microbiome and metabolome have been associated with an increased risk of diabetes in non-pregnant populations. However, such prospective studies in pregnant women are scant. We aimed to develop and validate microbiome-derived metabolite predictive markers in (...)
• 02:00
  108-OR: The Effect of Human Pregnancy on Morphology of the Endocrine Pancreas - EGAN AM, HER TK, VELLA A, et al. Diabetes
  In animal models, pregnancy is associated with distinct morphological and functional adaptations in the endocrine pancreas, particularly characterized by ? cell hyperplasia and hypertrophy. Failed islet adaptation to increased metabolic demands in pregnancy contributes to the development of (...)
• 02:00
  1090-P: Prevalence of Diabetic Cardiomyopathy in an Electronic Health Record–Based Cohort - SEGAR MW, PATEL K, VADUGANATHAN M, et al. Diabetes
  Introduction: Diabetic cardiomyopathy (DbCM) is characterized by abnormal cardiac structure/function, associated with incident HF, and has a 67% prevalence in the community. However, the prevalence of DbCM in a real-world, electronic health record (EHR) system is not known.Methods: Adult (...)
• 02:00
  1091-P: Impact of Metabolic Syndrome and Metabolic Dysfunction-Associated Fatty Liver Disease on Cardiovascular Risk in People with and without Type 2 Diabetes - MATSUBAYASHI Y, FUJIHARA K, YAMADA MH, et al. Diabetes
  This study aims to examine the impact of the association between metabolic syndrome (MetS) and metabolic dysfunction-associated fatty liver disease (MAFLD) , which both have insulin resistance and are pathophysiologically similar, on the development of new-onset cardiovascular disease, with and (...)
• 02:00
  1092-P: Lipoprotein Insulin Resistance Index and Mortality in Heart Failure: A Population Study - TURECAMO S, WOLSKA A, OTVOS JD, et al. Diabetes
  Heart failure (HF) is associated with metabolic alterations, including insulin resistance (IR) . Perturbations in lipid metabolism and insulin signaling may impact outcomes, but the relationship between IR and mortality is not well characterized. The Lipoprotein Insulin Resistance Index (LPIR) (...)
• 02:00
  1209-P: Genetic Subtypes of Prediabetes, Healthy Lifestyle, and Risk of Type 2 Diabetes in U.S. Hispanics - LI Y, CHEN G, MOON J, et al. Diabetes
  Prediabetes is a heterogenous metabolic condition. We calculated 5 pathway-based partitioned polygenetic risk scores (pPRS: beta-cell, proinsulin, obesity, lipodystrophy and liver/lipid scores) based on 94 type 2 diabetes (T2D) -associated variants in 3677 individuals with prediabetes from the (...)
• 02:00
  120-OR: Hepatic Steatosis Is Inversely Associated with Improvement of Pancreatic Beta-Cell Function after Vertical Sleeve Gastrectomy in Patients with Type 2 Diabetes - NAKAMURA A, OE Y, KUSUMI M, et al. Diabetes
  Background: Improvement of beta-cell function is reportedly involved in the improvement of glucose tolerance and remission of diabetes after bariatric and metabolic surgery. However, the impact of this surgery on beta-cell function in Japanese patients is not clear. The objective of this study (...)
• 02:00
  1210-P: Associations between HbA1c, Area Level Social Vulnerability, and Poor COVID-Outcomes - HOWELL CR, ZHANG L, WILLIAMS S, et al. Diabetes
  Background: HbA1c has been associated with COVID-poor outcomes in diabetic and non-diabetic populations, while patients living in census tracts with high levels of social vulnerability [measured using the CDC’s Social Vulnerability Index (SVI) ] have experienced poorer outcomes.Objective: To (...)
• 02:00
  1234-P: Serum Fatty Acid Composition as a Biomarker of Diabetes Development: Tokushima Cohort Study - HATA A, AKI N, ICHIHARA T, et al. Diabetes
  Few prospective cohort studies still exist on the association between serum fatty acid (FA) proportions and the enzymes involved in their synthesis and the onset of type 2 diabetes (T2D) . Thus, the aim of the present study was to investigate whether or not serum FA proportions or FA ratios, (...)
• 02:00
  1235-P: A Prospective Characterization of Metabolic and Metabolomic Profiles of COVID-19–Associated New-Onset Diabetes Patients Presenting with DKA from India - DASGUPTA R, MONDAL S, GARAI R, et al. Diabetes
  Background: Recent evidence suggests a bidirectional relationship between COVID-infection and new-onset diabetes (NOD) presenting with DKA.Methodology: This one-year prospective study comprised of 29 COVID-negative DKA (controls) and 52 COVID-positive-DKA patients (18 NOD, 15 T1DM ,T2DM) . NOD (...)
• 02:00
  1282-P: Genetic Susceptibility of Dipeptidyl Peptidase-4 Inhibitor–Associated Bullous Pemphigoid in Chinese Patients with Type 2 Diabetes - SHI M, YANG A, CHOW E, et al. Diabetes
  Objective: The rare risk association of bullous pemphigoid (BP) with use of dipeptidyl peptidase-4 inhibitors (DPP-4i) had been reported including genetic association with HLA variants. We assessed genetic susceptibility of BP associated with DPP-4i use in patients with type 2 diabetes (T2D) (...)
• 02:00
  1283-P: Paired Box 4 R192H (rs2233580) Variant Associated with Type 2 Diabetes Influenced the Response to the Treatment with Hypoglycemic Agents - TEERAWATTANAPONG N, TANGJITTIPOKIN W, SRISAWAT L, et al. Diabetes
  Paired Box 4 (PAX4) variants increase the risk of type 2 diabetes (T2D) and influence response to the treatment with hypoglycemic agents (HAs) in certain Asian populations. However, the influence of PAX4 variants associated with T2D on response to the treatment with different HAs and their (...)
• 02:00
  1284-P: Genetic and Lifestyle Associations with Cardiometabolic Traits and Diabetes Risk Factors in Ethnically Diverse Africans - HUI D, HARRIS D, MCQUILLAN M, et al. Diabetes
  African ancestry populations are underrepresented in human genetic studies, which leaves a knowledge gap about genetic and environmental risk factors for metabolic disease which can bias healthcare treatment. To alleviate these shortcomings, we conducted a series of genome-wide association (...)
• 02:00
  453-P: Role of JARID2 in Regulating Inflammatory Genes via Epigenetic Mechanisms in Monocyte/Macrophages in Type 2 Diabetes - REDDY MA, TANWAR VS, ZHANG L, et al. Diabetes
  The activation of monocytes and macrophages plays a central role in chronic inflammation associated with type 2 diabetes mellitus (T2D) and cardiovascular disease. However, the precise epigenetic mechanisms involved are unclear. From RNA-seq analysis we found dysregulated expression of several (...)
• 02:00
  454-P: Association between Insulin and C-Reactive Protein: Data from Athletes and Coronary Angiography Patients - LEIHERER A, RINDERER M, MUENDLEIN A, et al. Diabetes
  A better understanding of the relationship between insulin and inflammation may have important implications for the treatment and prevention of diabetes. Chronic inflammation and diabetes are associated with coronary artery disease (CAD) . That said, many studies found no correlation between (...)
• 02:00
  455-P: Artificial Intelligence Approach to Treatment Classification in Painful Diabetic Neuropathy - TEH K, WILKINSON ID, SLOAN GP, et al. Diabetes
  Aim: Our study predicted treatment responses in patients with painful DPN (diabetic peripheral neuropathy) by developing a deep learning model using resting state functional magnetic resonance imaging (fMRI) neuroimaging datasets.Methods: Forty-three consecutive patients who received (...)
• 02:00
  456-P: HMGB1 Inhibition Protects Schwann Cells from High Glucose–Induced Cytotoxicity - SHI M, SONG J, CHEN Y, et al. Diabetes
  Objective: Damage to Schwann cells play a crucial role in diabetic peripheral neuropathy (DPN) . To observe whether HMGB1 inhibitor (Glycyrrhizic acid, GA) can prevent diabetic Schwann cells damage and its potential mechanisms.Methods: RSC96 cells were divided into 5 groups: NG group (5.6 (...)
• 02:00
  457-P: Increase in Functional Connectivity of the Thalamus to the Primary Somatosensory Cortex and Insular Cortex after Withdrawal of Neuropathic Pain Medication: A Potential Biomarker of Painful-DPN - SLOAN GP, SELVARAJAH D, TEH K, et al. Diabetes
  Aims: Altered functional connectivity has been identified in key brain regions involved in somatosensory perception in patients with painful diabetic peripheral neuropathy (painful-DPN) , using resting state functional-magnetic resonance imaging (fMRI) . This study aimed to examine the impact (...)
• 02:00
  458-P: Inflammatory Markers and Cardiovascular Autonomic Neuropathy in Type 1 Diabetes - ANG L, GUNARATNAM SG, HUANG Y, et al. Diabetes
  Objective: We aimed to assess the role of chronic inflammation in the pathogenesis of cardiovascular autonomic neuropathy (CAN) , a serious complication of type 1 diabetes (T1D) .Methods: We leveraged an ongoing randomized, placebo-controlled clinical trial targeting inflammation with salsalate (...)
• 02:00
  459-P: Effects of Liraglutide on Somatic Nerve Function in Subjects with Type 2 Diabetes - CASELLINI CM, PARSON H, BAILEY MD, et al. Diabetes
  Background: Preclinical data has shown that GLP-1 receptor agonists play a role in nerve regeneration and repair. However, few studies have investigated the effects of these compounds on nerve function in humans. The aim of this study was to examine the effect of Liraglutide (Lira) on somatic (...)
• 02:00
  676-P: Difference in CGM Estimated Hemoglobin A1c in Adults with Type 1 and Type 2 Diabetes - SALAM M, BAILEY R, CALHOUN P, et al. Diabetes
  The relationship between mean glucose measured using a continuous glucose monitor (CGM) and hemoglobin A1c (A1C) was evaluated in adults with type 1 diabetes (T1D) or type 2 diabetes (T2D) . Data from participants enrolled in the MOBILE, DIAMOND, and WISDM trials and randomized to the CGM arm (...)
• 02:00
  677-P: Impact of Third Dose COVID-Vaccination on Glycaemic Control in Individuals with Type 1 Diabetes Using Flash Glucose Monitoring - PIERALICE S, MONTE L, DEFEUDIS G, et al. Diabetes
  Background: Coronavirus (COVID-19) disease portends a poor prognosis in patients with type 1 diabetes (T1D) . As a consequence, the booster dose of Covid-vaccination should be prioritized in these patients. Nonetheless, concerns exist about vaccine-induced dysglycemia.Objectives: Aim of this (...)
• 02:00
  678-P: Racial and Ethnic Disparities in CGM Use among Adults with Diabetes - ALJEDAANI SM, SIDDIQUI AS, RAJA-KHAN N. Diabetes
  Introduction: Continuous glucose monitoring (CGM) is increasingly being used in the management of diabetes. Racial disparities in use of CGM may contribute to disparities in health outcomes. Studies have shown disparities in use of CGM among different races. However, most of these studies were (...)
• 02:00
  774-P: Impact of Transition to Tandem Control-IQ on Sleep Awakenings in Youth with Type 1 Diabetes (T1D) and Their Parents - KARAMI AJ, PYLE L, VIGERS TB, et al. Diabetes
  Youth with T1D and their parents are susceptible to diabetes-related nocturnal awakenings, which have been associated with reduced sleep duration and quality. We conducted an observational study of youth with T1D starting on the Tandem Control-IQ (CIQ) hybrid closed-loop (HCL) system to (...)
• 02:00
  775-P: Effect of Optimized Settings during Six Months of Real-World MiniMed 780G Advanced Hybrid Closed-Loop (AHCL) Therapy Use in Chile - CASTRO M, CARRASCO BONILLA C, LEON MACEDO JC, et al. Diabetes
  Background and Aims: The pivotal trial of the MiniMed™ 780G system showed that optimized settings of active insulin time (2 hours) and target glucose (100mg/dL) improved glycemic outcomes.1 This study analyzed real-world glycemic outcomes of individuals with T1D in Chile, 6 months after AHCL (...)
• 02:00
  776-P: Glycemic Outcomes after Six Months of Real-World MiniMed 780G Advanced Hybrid Closed-Loop (AHCL) Therapy Use in Chile - CASTRO M, CARRASCO BONILLA C, LEON MACEDO JC, et al. Diabetes
  Objective: MiniMed™ 780G system use has improved glycemic control in clinical trials1,2 and real-world data analyses3. This study evaluated real-word glycemic outcomes before and 6 months after AHCL initiation by individuals with T1D living in Chile.Methods: Data from 37 MiniMed™ 780G users (aged (...)
• 02:00
  777-P: Short-Term Continuous Subcutaneous Insulin Infusion Treatment Improves Peripheral Autonomic Neuropathy in Type 2 Diabetes - JIN J. Diabetes
  Background: Short-term continuous subcutaneous insulin infusion treatment (CSII) in patients with newly diagnosed type 2 diabetes (T2DM) can improve ?-cell function and insulin sensitivity, which results in long-term remission. However, the effect of CSII on peripheral neuropathy is rarely (...)
• 02:00
  778-P: Variations in Insulin Pump Use across Pediatric Endocrinology Centers in the U.S. - MUNGMODE A, ADAMS BV, DOCTER O, et al. Diabetes
  Background: The T1D Exchange Quality Improvement Collaborative (T1DX-QI) is a learning network of over forty US type 1 diabetes clinics. Clinics share best-practice ideas for quality improvement and use data for population health research. This study benchmarks insulin pump use across pediatric (...)
• 02:00
  779-P: Announced Meals at Will with the MINIMED Advanced Hybrid Closed-Loop - MINSKY N, HIRSH M, SHALIT R, et al. Diabetes
  Background: We compared glycemic outcomes and participant experience during MiniMed™ 780G Advanced Hybrid Closed Loop (AHCL) system use while announcing all meals vs. announcing meals at will.Methods: Participants with T1DM used the AHCL system at home during two 90 days phases in which they (...)
• 02:00
  77-LB: How the Incidence of Anxiety and Other Psychosocial Factors Impact Quality of Life in Parents of Children with Type 1 Diabetes Who Used a Continuous Glucose Monitor (CGM) —A Systematic Review - SAWYER BC, HUTSON LM, CIPRICH AP. Diabetes
  This study aimed to perform a systematic review related to how anxiety and other psychosocial factors impact quality of life in parents and their children with type 1 diabetes (T1D) who utilize a continuous glucose monitor (CGM) . Electronic databases and published references were utilized to (...)
• 02:00
  77-OR: Native LDL Upregulate the NLRP3 Inflammasome in Human Adipose Tissue: A Mechanism for Higher Risk for Type 2 Diabetes in Subjects with HyperapoB - BISSONNETTE S, LAMANTIA V, CYR Y, et al. Diabetes
  Background and Hypothesis: Elevated plasma apoB-lipoproteins (hyperapoB, mostly LDL) predicts the incidence of type 2 diabetes (T2D) and its risk factors including systemic activation of the interleukin-1 system (measured as plasma IL-1 receptor antagonist, IL-1Ra) . Moreover, native LDL induce (...)
• 02:00
  780-P: Associations between Insulin Pump Self-Management and HbA1c - RYTTER K, MADSEN KP, ANDERSEN HU, et al. Diabetes
  Background and Aims: It is well-known that diabetes self-management is important for glycemic outcome, also among insulin pump users. We aimed to explore which factors were independently associated with HbA1c.Methods: Adult insulin pump users (18+) with type 1 diabetes from the Capital Region (...)
• 02:00
  781-P: Progressive Acceleration of Insulin Exposure over Seven Days of Infusion Set Wear - BAILEY TS, KASTNER JR, STRANGE P, et al. Diabetes
  Insulin exposure and action are known to differ on each of 3 days of infusion set wear during CSII. We extend these observations to 1 week in a pilot phase study comparing conventional Teflon angled infusion sets to a prototype extended wear set using Capillary Biomedical SteadiFlow™ technology. (...)
• 02:00
  782-P: Swimming with Hybrid Closed-Loop: Connectivity Data from Seven Swimmers in the Omnipod 5 Trial - HUGHES MS, KINGMAN RS, HSU L, et al. Diabetes
  The Omnipod® 5 Automated Insulin Delivery System is a waterproof (IP28) hybrid closed-loop system where the continuous glucose monitor (CGM) communicates directly with the algorithm on the Pod to modulate insulin delivery automatically. However, the system relies on Bluetooth® wireless (...)
• 02:00
  1098-P: Impact of Health Factors on Incident Cardiovascular Disease (CVD) According to Glucose Tolerance Status - IIJIMA T, FUJIHARA K, YAMADA MH, et al. Diabetes
  Breslow’s Health Practice Index (HPI) includes recommendations for a healthy lifestyle and is composed of 7 simple lifestyle factors (sleep, breakfast, snacks, body mass index (BMI) , physical activity, drinking alcohol, and smoking status) . Cardiovascular health metrics (CVHMs) defined (...)
• 02:00
  1099-P: Truncal Fat–to–Leg Fat Ratio and Carotid Plaque Score in Patients with Type 2 Diabetes - SHIN J. Diabetes
  High truncal fat is known to be a risk factor for cardiovascular disease (CVD) , but high leg fat has a protective effect on CVD. We investigated the association between truncal fat-to-leg fat ratio (TLR) and carotid plaque score PS) in patients with type 2 diabetes (T2D) . A total of 1966 (...)
• 02:00
  109-LB: An Investigation into Local Infusion Site Pain after Infusion of URLi Excipients across Sites and Depths - IGNAUT DA, FUKUDA T, RAMANJINEYULU B, et al. Diabetes
  A Phase 1, randomized, 1-day 5-period crossover study in adults with type 1 diabetes on CSII investigated whether pain is dependent on the site and/or depth of infusion of ultra rapid lispro (URLi) excipients.Forty participants (mean age 40.5 years; BMI 27.5) were randomized to 1 of 5 infusion (...)
• 02:00
  1138-P: Impact of Continuous Glucose Monitoring (CGM) on Glycemic Control and Acute Complications in Type 2 Diabetes (T2D) in the Veterans Health Administration (VHA) - REAVEN P, NEWELL M, RIVAS S, et al. Diabetes
  Use of CGM in T2D is rising rapidly, yet little is known regarding its effects on glucose management in the VHA. We thus identified new CGM users (new CGM sensor prescriptions for T2D on insulin) and non-users (T2D receiving glucose strips) during the years 2015-2020 and used national VHA (...)
• 02:00
  1139-P: The Association between Age of Onset of Type 2 Diabetes and the Long-Term Risk for Major Diabetes-Related Complications - MORTON JI, LAZZARINI P, POLKINGHORNE K, et al. Diabetes
  We evaluated the association between age of onset of type 2 diabetes and the risk for major diabetes complications. We included 1.1 million people with type 2 diabetes from the Australian diabetes registry, followed from 2010-2019. We evaluated the incidence of hospitalization for, or death (...)
• 02:00
  113-LB: Oral Menin Inhibitor, BMF-219, Displays a Significant and Durable Reduction in HbA1c in a Type 2 Diabetes Mellitus Rat Model - SOMANATH P, MOURYA S, LI W, et al. Diabetes
  Menin is an epigenetic regulatory protein that plays a key role in beta-cell proliferation and function, as previously demonstrated though increased beta-cell mass generation in Men1 knockout mice (Ja et al., 2021;13 (5) :e13524) . Here, we demonstrate the marked potential of an oral menin (...)
• 02:00
  113-OR: The Best Insulin Delivery System Remains a Human Pancreas - MCCUNE KR, DUBE G, RATNER LE. Diabetes
  Purpose: Patients referred for pancreas transplantation represent a subset of difficult to treat diabetics, who may have clinical factors preventing them from achieving a goal Hgb A1C of ?7%. Advanced insulin delivery systems with continuous glucose monitor (CGM) have been developed to offer (...)
• 02:00
  1171-P: Food Insecurity and Glycemic Goals among Medicare Beneficiaries with Type 2 Diabetes - NG B, STEWART MP, LAMANNA JB, et al. Diabetes
  Food insecurity, a modifiable risk factor, has a significant impact on individuals' health and well-being. This study examined the association between food insecurity and glycemic goals among Medicare beneficiaries aged ?65 years with type 2 diabetes (T2D) , using the 20Medicare Current (...)
• 02:00
  1172-P: Higher Dairy Consumption Is Associated with Lower Risk of Type 2 Diabetes among U.S. Adults: A Nationally Representative Study - TOMAH S, HAMDY O. Diabetes
  Dairy consumption has been associated with a modestly lower risk of type 2 diabetes and other components of the metabolic syndrome in few cohort studies. However, confounding by overall diet quality and physical activity levels remains present. We evaluated 4,934 adults who participated in the (...)
• 02:00
  11-OR: Transcriptome Heterogeneity in Insulin-Positive Insulitic vs. Noninsulitic Human Islets in Type 1 Diabetes (T1D) - DYE AM, ASHBERY G, LENCHIK NI, et al. Diabetes
  Insulitis involves the infiltration of predominantly CD3+ T cells in islets in a patchy distribution between lobes in a pancreas. We hypothesized that gene expression profiling of insulin containing islets (INS+CD3-) vs. insulin containing insulitic islets (INS+CD3+) would show heterogeneity in (...)
• 02:00
  1297-P: Berberine Derivatives as Novel Antidiabetes Agents Targeting Intestinal AMPK and Antimicrobial Peptide-Controlled Gut Microbiome - ZHANG E. Diabetes
  Mammalian 5?-AMP-activated protein kinase (AMPK) is a key nutrient sensor for maintaining cellular energy status and a known therapeutic target for glucose control in type 2 diabetes (T2D) . Despite current understandings of its well-established roles in regulating glucose metabolism in various (...)
• 02:00
  1298-P: Metabolic Clearance of Insulin Is Altered after Gastric Bypass and Sleeve Gastrectomy - RAYAS MS, DEFRONZO RA, GASTALDELLI A, et al. Diabetes
  Roux-en-Y gastric bypass (GB) surgery and sleeve gastrectomy (SG) improve glucose tolerance, in part, by enhancing prandial insulin levels. Post-meal hyperinsulinemia after GB is caused by larger insulin secretion and lower metabolic clearance rate of insulin (MCRI) . Reduced prandial MCRI (...)
• 02:00
  1299-P: Novel Tools to Dissect the Metabolic Roles of Central and Peripheral Dopamine D2-Like Receptors - BONIFAZI A, ELLENBERGER MP, FARINO Z, et al. Diabetes
  Dopamine (DA) D2-like receptors are key physiological modulators of metabolism under healthy and disease states. While D2-like receptors are expressed both in the central nervous system (CNS) and within the periphery, the respective metabolic roles of CNS and peripheral D2-like receptors remain (...)
• 02:00
  129-LB: The Impact of a Passive Alert on Screening for Euglycemic Diabetic Ketoacidosis in Hospitalized Patients Using an Sodium–Glucose Cotransporter 2 Inhibitor - SOLIMAN D, MUSSER R, JACKSON JP, et al. Diabetes
  The use of sodium-glucose cotransporter-2 (SGLT2) inhibitors has recently been associated with euglycemic diabetic ketoacidosis (euDKA) . The absence of hyperglycemia can delay recognition of euDKA. We aimed to increase screening rates for euDKA by implementing a passive alert to providers in (...)
• 02:00
  129-OR: Catastrophic Health Expenditures: A Disproportionate Risk in Uninsured Ethnic Minorities with Diabetes - LINDE S, EGEDE LE. Diabetes
  Background: Chargemaster prices are the list prices that providers and health systems assign to each of their medical services in the US. These charges are often several factors of magnitude higher than those extended to individuals with either private or public insurance, however, these list (...)
• 02:00
  12-LB: A Prediction Model on Incident End-Stage Kidney Disease (ESKD) among Individuals with Type 2 Diabetes (T2D) and Chronic Kidney Disease (CKD) - LIN Y, SHAO H, ANDERSON AH, et al. Diabetes
  Diabetes is the leading cause of ESKD, a costly and disabling condition that often results in premature death. This study aimed to predict incident ESKD among individuals with T2D comorbid with CKD. The ACCORD clinical trial data were split into a training set and a validation set by a ratio of (...)
• 02:00
  1466-P: Pancreatic Delta Cells Switched Islet's Ca2+ Oscillation Modes by Inhibiting Endogenous Glucagon from Alpha Cells - REN H, GROUP C, GROUP L. Diabetes
  Glucose-stimulated pancreatic islets show different patterns of Ca2+ signaling with fast, slow and mixed fast/slow oscillations. However, it is not clear whether they are characteristic features of individual islets. We report islet spontaneous slowdown from fast to slow/mixed Ca2+ oscillation (...)
• 02:00
  1467-P: Chemical Profiles of Acinar Tissue and Pancreatic Islets from Healthy and T2D-Affected Pancreata - RUBAKHIN S, ROMANOVA EV, SWEEDLER JV. Diabetes
  Both the endocrine and exocrine pancreas demonstrate morphological and chemical changes associated with T2D development. Despite significant progress, chemical profiles of the islets and acinar tissue following disease progression are not well characterized. In this work we investigated (...)
• 02:00
  1468-P: Effect of Kcnq1ot1 on Influencing the Function of Pancreatic ß-Cells Targeting miR-92a-1-5p - CHEN Y, LI Y, XU W, et al. Diabetes
  Objective: To study the role and mechanism of Kcnq1ot1 by targeting to regulate miR-92a-1-5p to effect insulin secretion in pancreatic ? cells.Methods: The qRT-PCR was used to detect the expression of Kcnq1ot1 in different tissues of C57BL/6J mice, Min6 with PA intervention, islets of T2D model (...)
• 02:00
  1469-P: Inhibition of the Integrated Stress Response Increases PD-L1 in Islet ß-Cells and Protects against Autoimmune Diabetes - HUANG F, KULKARNI A, SYED F, et al. Diabetes
  Type 1 diabetes (T1D) has become viewed as an autoimmune disease initiated and propagated by stress responses in islet ? cells. The integrated stress response (ISR) is activated upon inflammatory signaling and delimits protein production through the actions of phospho-eIF2?. We hypothesized that (...)
• 02:00
  146-LB: Impact of the COVID-19 Pandemic on Quality of Life in Youth with Type 1 Diabetes - COBRY EC, PYLE L, VIGERS TB, et al. Diabetes
  Diabetes is a risk factor for COVID-19 infection-related complications, increasing fear in this population. The effect of the pandemic on quality of life for youth with type 1 diabetes (T1D) has not been evaluated.Youth with T1D (n=108, mean age 11.6±4.0 yrs, mean T1D duration 5.3±3.9, 57.4% (...)
• 02:00
  146-OR: Loss of Hydroxycarboxylic Acid Receptor 2 (HCA2) Affects Adipose Tissue Homeostasis in a Sex-Specific Manner during Prolonged Fasting - MCCAFFERTY KJ, BRINKER E, GRAFF E, et al. Diabetes
  Hydroxycarboxylic acid receptor 2 (HCA2) , formally known as GPR109A, is a metabolite-sensing receptor expressed predominately on adipocytes, immune cells and intestinal epithelial cells. The primary endogenous ligand of HCA2 is ?-hydroxybutyrate (?OHB) , which is elevated during periods of (...)
• 02:00
  1470-P: GABA Stimulates or Inhibits Insulin and Somatostatin Secretion in Human Pancreatic Islets Depending on Glucose Concentration - FERREIRA S, HAGAN DW, PHELPS E. Diabetes
  GABA is an inhibitory neurotransmitter synthesized and secreted by ?-cells that is reported to modulate glucagon, somatostatin (SST) , and insulin secretion. However, the direction of the effect of GABA, whether stimulatory or inhibitory, on insulin secretion is controversial. Our results from (...)
• 02:00
  1405-P: Bacteroides thetaiotaomicron Fortifies the Gut Mucosa and Improves Host Metabolism in Dietary Obese Mice - LEE J, WELLENSTEIN K, KAHN BB. Diabetes
  Disruption of the intestinal mucosa contributes to insulin resistance in obesity and Type 2 diabetes. Probiotic supplementation, which restores gut microbiota composition and fortifies intestinal barrier function, has therapeutic potential to treat obesity and metabolic disease. Treatment of (...)
• 02:00
  1406-P: ZP8396, a Novel Amylin Analogue, Induces Weight Loss in DIO Rats with a Formulation Space at Physiological pH - SKARBALIENE J, LUNDQVIST J, VILLADSEN J. Diabetes
  ZP8396, currently in phase 1, is a long-acting, amylin analogue designed to improve solubility and stability and allow for co-formulation with other peptides at physiological pH. Here we present in-vivo efficacy and formulation design space of ZP8396. The acute effects on body weight (BW) loss (...)
• 02:00
  340-OR: LY3437943 (LY) , a Novel Triple GIP/GLP-1/Glucagon Receptor Agonist, Provides Glucose Lowering and Weight Loss in Patients with T2DM after 12 Weeks of Treatment - URVA S, LOH M, COSKUN T, et al. Diabetes
  Multi-receptor incretin agonists are being developed for several metabolic disorders. LY is an investigational triple agonist with potent activity on glucose-dependent insulinotropic polypeptide (GIP) , glucagon-like polypeptide-1 (GLP-1) , and glucagon receptors. LY was safely studied in a (...)
• 02:00
  341-OR: Enhanced Responsiveness of ß- and ?-Cells to Glucagon-Like Peptide-1 (GLP-1) in Youth vs. Adults with Impaired Glucose Tolerance (IGT) or Drug-Naïve Type 2 Diabetes (T2D) - NADEAU KJ, TJADEN AH, EHRMANN DA, et al. Diabetes
  In the Restoring Insulin Secretion (RISE) Study, youth (Y) compared to adults (A) had enhanced ?-cell (greater incremental C-peptide [CP] responses) and ?-cell responsiveness (greater glucagon [GG] suppression) . As GLP-1 increases CP and decreases GG, we measured GLP-1 (Mercodia) during a 3-h (...)
• 02:00
  342-OR: Low Incretin Effect Is Associated with Longitudinal Decline of Beta-Cell Function and Insulin Sensitivity in Obese Youth - GALDERISI A, LAT JO, SAMUELS S, et al. Diabetes
  Background: We assessed the longitudinal trajectory of beta-cell function with respect to baseline incretin effect in youth with obesity.Methods: At baseline and two years, youth with obesity and 2-h glucose ? 120mg/dL underwent a 3-hour OGTT and isoglycemic intravenous glucose infusion (to (...)
• 02:00
  588-P: Examining Psychosocial and Comorbidity Factors Associated with Diabetes Distress among Medicaid Beneficiaries - VERDECIAS N, MCQUEEN A, SMITH RE, et al. Diabetes
  Evidence supports diabetes distress’ (distress hereafter) effect on diabetes self-management. Few studies have examined factors that influence distress. We used self-reported cross-sectional data from Medicaid beneficiaries in Louisiana to examine psychosocial and clinical factors and their (...)
• 02:00
  589-P: Health Disparities among People with and without Diabetes during COVID-19: An 18-Month Evaluation - MYERS BA, KLINGENSMITH R, CASANOVA I, et al. Diabetes
  This study describes the mental health of US adults with and without diabetes (ND) over an 18-month period of the COVID-pandemic. A 12-month web-based survey was administered in May 2020 (N = 2,176) to June 2021 and November 2021 (18MO; N = 1,192) including demographics, pandemic experiences, (...)
• 02:00
  805-P: Sarcopenia in Insulin-Treated Older Adult Patients with Type 2 Diabetes - LEITE SO, BASTOS M, SILVA M, et al. Diabetes
  Background: The relationship of sarcopenia with relevant features of T2D and its treatment are inconsistent in the literature.Aims: To evaluate the prevalence of sarcopenia in insulin treated older adults with T2DM.Methods: This is a cross sectional data from a prospective observational cohort (...)
• 02:00
  806-P: Correlation of Derived Time in Range (dTIR) and Time in Range (TIR) in People with Type 2 Diabetes (T2D) Treated with IDegLira (IDL) , Degludec, or Liraglutide: A Post Hoc Analysis of the DUAL I Trial - PHILIS-TSIMIKAS A, DCRUZ JM, SIVARATHINASAMI R, et al. Diabetes
  Background and Aims: TIR (blood glucose 70-180 mg/dL) , measured by continuous glucose monitoring (CGM) , provides a more comprehensive picture of glycemic control than A1c alone. Derived TIR (dTIR) , a calculated estimate of TIR, is useful when CGM data are unavailable. This post hoc analysis (...)
• 02:00
  807-P: Glycemic Control in People with Type 2 Diabetes (PWT2D) Switching from NPH to Insulin Glargine 300 U/mL (Gla-300) : REALI Pooled Database - MÜLLER-WIELAND D, FREEMANTLE N, BONADONNA RC, et al. Diabetes
  The effectiveness of Gla-300 in PWT2D switching from NPH is not widely documented. REALI database combines individual data from 14 European studies in T2D. We analyzed data from PWT2D uncontrolled on prior basal insulin (BI) , 1282 switching from NPH and 2899 from other non-NPH BIs (mainly (...)
• 02:00
  808-P: Association between Analogue Compared with Human Insulin and the Outcomes of Mortality, Hospitalization, MACE, and Hypoglycemia in Hemodialysis Patients with Type 2 Diabetes: The ARO Research Initiative - EBERT T, SATTAR N, GREIG M, et al. Diabetes
  Aims: Poor glycemic control may contribute to the very high mortality rate in patients with type 2 diabetes (T2D) receiving hemodialysis (HD) . Whether analogue compared to human insulin therapy associates with different outcomes is unknown.Methods: Incident HD patients with T2D on insulin (...)
• 02:00
  1088-P: Racial, Socioeconomic, and Geographical Disparities in Cardiovascular Disease (CVD) among Medicare Beneficiaries with Diabetes (DM) - PARK J, ZHOU X, ZHANG P. Diabetes
  Despite a high prevalence of DM and CVD in older adults in the US, relatively little is known about how CVD prevalence varies by sociodemographic factors in older adults with DM. Using the 2017-20Medicare Current Beneficiaries Survey, we examined the prevalence of self-reported myocardial (...)
• 02:00
  1130-P: A Prospective Cohort Study on the Predictive Value of Controlled Attenuation Parameter Measured by FibroScan to the Transition of Metabolic Status - LI J, HUANG Z, DENG W, et al. Diabetes
  Aims: Our previous study validated that controlled attenuation parameter (CAP) was a sensitive surrogate marker for evaluating metabolic derangement. However, prospective studies are needed to assess its usefulness for transition of metabolic status over time. In this study, predictive effect (...)
• 02:00
  1131-P: Progression to Diabetes Despite a Baseline Fasting Plasma Glucose = 80mg/dL: A Population-Based Case-Control Study - MOHAN S, VELLA A, EGAN AM. Diabetes
  While elevations in baseline fasting plasma glucose (FPG) are associated with risk of type 2 diabetes mellitus (DM) , some individuals with lower FPG will also develop DM. The aim of this study was to identify factors associated with DM in people with a baseline FPG of ? 80mg/dL. Using the (...)
• 02:00
  1132-P: Classification and Prediction of Diabetes Using Electronic Health Records and Wearable Devices for Clinical Decision Support - SHAHIDEHPOUR A, FRITSCHI C, RASHID M, et al. Diabetes
  Introduction: Diagnosis of T2DM necessitates clinical tests that are time-consuming and expensive. Machine learning (ML) techniques can accelerate the diagnosis and classification of T2DM and allow clinicians to personalize treatments based on blood glucose concentrations (BGC) , physical (...)
• 02:00
  1244-P: Glycemic Trend in the Second Year of LANDMARC—Longitudinal Nationwide Study on Real-World Outcomes of Type 2 Diabetes in India - JOSHI S, DAS AK, KUMAR K, et al. Diabetes
  Glycemic change from baseline to 2-years was examined during the second year of LANDMARC, a 3-year prospective observational study (CTRI/2017/05/008452) , which included participants with T2D taking ?2 antihyperglycemic medications (with/without glycemic control) . Out of 6234 evaluable (...)
• 02:00
  1437-P: Waist-to-Height Ratio Is a Better Indicator Instead of Waist Circumference for Diagnosing Metabolic Syndrome in Type 2 Diabetes - KE J, WANG J, MA Y, et al. Diabetes
  Waist circumference (WC) is currently one of the components of metabolic syndrome (MetS) , but the cutoff points of WC for diagnosing MetS vary between races and genders. Therefore, the aim of this study is to search an anthropometric indicator instead of WC that would be applicable across (...)
• 02:00
  1438-P: Association between Screen Time, Including That for Smartphones, and Overweight/Obesity among Children in Japan - IKEDA I, FUJIHARA K, MORIKAWA SY, et al. Diabetes
  The association between screen time (ST) , including that for smartphones, and overweight/obesity (OW/OB) in children was examined separately for boys and girls, considering the influence of lifestyle factors including diet, physical activity, and sleep time. A cross-sectional study was (...)
• 02:00
  1439-P: Association between Sleep Duration, Bedtime, and Hyperglycemia or Overweight/Obesity among Japanese Children - SHIOZAKI H, FUJIHARA K, YAMADA MH, et al. Diabetes
  In adults, short sleep duration and late bedtime were associated with hyperglycemia and obesity, but these relationships in children are little known. We evaluated the association of bedtime and sleep duration with overweight/obesity or hyperglycemia in children by sex, considering the effects (...)
• 02:00
  143-LB: Hepatic Insulin Resistance Index (HIR-I) in Youth—Does Race/Ethnicity Matter? - CHO W, BACHA F, TFAYLI HM, et al. Diabetes
  Surrogate indices for insulin resistance of various insulin-responsive tissues are critical in epidemiological studies of youth at risk for developing type 2 diabetes (T2D) . Having established surrogate indices for peripheral insulin sensitivity (JCEM 2011; 96:2136) , we aimed to develop HIR-I (...)
• 02:00
  143-OR: Mapping Genetic Determinants of Blood Glucose Control in the Action to Control Cardiovascular Risk in Diabetes Study Group (ACCORD) - HOUSE JS, ROTROFF DM, FONSECA V, et al. Diabetes
  The hemoglobin glycation index (HGI) is the difference between observed HbA1c and predicted HbA1c from FPG using linear regression. HGI is an important biomarker of clinical management/drug treatment outcomes and can identify individuals at high risk for multiple adverse events and outcomes (...)
• 02:00
  1440-P: Effects of Two Weight-Loss Medications, Liraglutide and Orlistat, on Liver Enzymes in Patients with Overweight or Obesity in a Real-World Setting - GORGOJO-MARTINEZ JJ, CHICHARRO P, FERREIRA-OCAMPO PJ, et al. Diabetes
  The aim of this analysis of the XENSOR study was to assess the effect of 2 weight-loss drugs on hepatic serum biomarkers in patients with overweight or obesity and insufficient weight loss (WL) after a lifestyle modification program. A retrospective real-world study (RWS) was conducted (...)
• 02:00
  1441-P: Fidelity of BMI and Waist Circumference as Adiposity Measures in White and Black Adults - LIU Z, PATEL AA, DAGOGO-JACK S. Diabetes
  Background: Body mass index (BMI) and waist circumference (WC) are routine clinical estimates of obesity. We tested the fidelity of BMI and WC against direct body fat measures in Black (B) vs. White (W) Americans.Subjects and Methods: We analyzed the relationship between BMI vs. total fat, WC (...)
• 02:00
  1442-P: Association of Elevated Serum FABP1 with Hyperuricemia in Patients with Obesity and the Alteration after Sleeve Gastrectomy - QU S, HUI Y. Diabetes
  Aims: FABP1’s relationship with obesity-related hyperuricemia remains unknown. We aimed to evaluate FABP1-level changes in patients with obesity-related hyperuricemia and changes after laparoscopic sleeve gastrectomy (LSG) .Materials and Methods: Participants were categorized according to uric (...)
• 02:00
  1097-P: Value of Blood Pressure Measurement Earlier vs. Later in Life to Predict Cardiovascular Mortality - LEIHERER A, ULMER H, MUENDLEIN A, et al. Diabetes
  We here aimed at comparing the value of systolic blood pressure (BP) earlier versus later in life to predict cardiovascular mortality. In a cardiovascular observation study (OS) we prospectively recorded fatal cardiovascular events over up to years in 1282 patients of whom 570 had the Metabolic (...)
• 02:00
  1350-P: Elucidation of Terminal Fatty Acid–Derived Acetyl-CoA Preference for Ketogenic Flux - MCLEOD M, RAGAVAN M, RUSHIN A, et al. Diabetes
  Insulin resistance is a major contributor to nonalcoholic fatty liver disease (NAFLD) . NAFLD is a progressive disease that leads to impaired hepatic function and liver cirrhosis. Increased ketogenesis has been correlated with a protective phenotype in mice and humans. During our study we (...)
• 02:00
  1455-P: The Loss of Pancreatic ß-Cell Complement 1q-Like-3 Secreted Protein Increases Insulin Secretion in Lean and Obese Mice - RAHMAN M, MD, ALSHARIF H, BHATNAGAR S. Diabetes
  Previously, we identified complement-1q like-3 (C1ql3) secreted protein as a hub gene affecting pancreatic islet function in obese mice using network biology. We demonstrated that the recombinant C1ql3 protein inhibits insulin secretion stimulated by exendin-4 (an agonist for GLP-1 receptor) (...)
• 02:00
  1456-P: Molecular Architecture of AR Action in Insulin Secretion in Male Pancreatic ß-Cells - MOTA DE SA P, QADIR M, BLANDINO-ROSANO M, et al. Diabetes
  Male mice lacking the androgen receptor (AR) in islet ? cells exhibit blunted glucose-stimulated insulin secretion (GSIS) , leading to hypoinsulinemia and hyperglycemia. We showed that dihydrotestosterone (DHT) activation of an extranuclear AR in ? cells potentiates GSIS by amplifying the (...)
• 02:00
  1457-P: Cholesterol Accumulation in Islets Increases Steroidogenic Acute Regulatory (StAR) Protein Expression and Decreases Islet Cell Viability and ß-Cell Function - AKTER R, HOGAN MF, ESSER N, et al. Diabetes
  Diabetes is associated with elevated plasma cholesterol (Chol) , with its intracellular accumulation resulting in ?-cell dysfunction. In steroidogenic tissues, StAR facilitates Chol transport from the outer to inner mitochondrial membrane for subsequent metabolism. We have shown that StAR is (...)
• 02:00
  1458-P: Lipophagy Is Constitutively Active in Pancreatic Beta Cells and Maintains Insulin Secretion - LIU S, BRENNECKE BR, YANG U, et al. Diabetes
  Lipid droplets (LDs) , organelles important for intracellular lipid metabolism, are actively formed in rat and human adult beta cells and affect islet function and health. Acute mobilization of LDs by adipose triglyceride lipase in beta cells is known to support insulin secretion. As LD (...)
• 02:00
  1459-P: Human Islet Cell Transcriptome Analysis Using Single Nucleus RNA-seq Reveals New Beta-Cell Markers and Define Distinct Beta-Cell Subpopulations with Different Transcriptional Activity - KANG R, LI Y, ROSSELOT C, et al. Diabetes
  Single-cell RNA sequencing (scRNA-seq) of human islets requires cell dissociation and does not provide information on the transcriptional status of islet cells. On the other hand, single-nucleus RNA sequencing (snRNA-seq) does not require cell dissociation and provides abundant information on (...)
• 02:00
  145-LB: Regional Grey Matter Volume and Cerebral Blood Flow in Obese Youth With and Without Type 2 Diabetes - BRADY R, SHAH AS, DIFRANCESCO MW. Diabetes
  Neurocognitive decline, dementia and stroke are associated with obesity and type 2 diabetes (T2D) in adults. Volumetric brain changes and cerebral vascular impairment, which may mediate these outcomes, have been demonstrated in youth-onset T2D and obesity. A key to understanding the brain (...)
• 02:00
  165-OR: Norepinephrine Acts on Glutamatergic Neurons in the Ventromedial Hypothalamus to Stimulate the Release of Counterregulatory Hormones - APPADURAI DA, CHAN O. Diabetes
  Release of glutamate in the ventromedial hypothalamus (VMH) is important for stimulating the counterregulatory hormone responses to hypoglycemia. It is currently not known whether VMH glutamatergic neurotransmission is influenced by adrenergic inputs. To address this question, we examined (...)
• 02:00
  166-OR: Brain Responses to Hypoglycemia following Contrasting Hypoglycemia Awareness Restoration Strategies: A Comparison of the HARPdoc and HypoAware Studies - JACOB P, AMIEL SA, NWOKOLO M, et al. Diabetes
  Background: Restoration of symptoms in response to hypogycemia has been seen in people with type 1 diabetes (T1D) and impaired awareness of hypoglycaemia (IAH) using an education and diabetes technology approach (HypoAware Study) and a psycho-educational approach addressing cognitions (HARPdoc (...)
• 02:00
  167-LB: Persisting Disparity in Prevalence of Diabetes in Appalachian Region of Kentucky between 2016–2020 - RAJ R, SADEK B, SEETHA M, et al. Diabetes
  Background: People in the Appalachian region of KY face serious and unique health challenges influenced by socioeconomic status, rural location, and culture. Diabetes prevalence in the Appalachian region of KY is known to be consistently higher when compared to national and state-wide (...)
• 02:00
  167-OR: Inequities in Glycemic Outcomes for Patients with Type 1 Diabetes: Six-Year (2016–2021) Longitudinal Follow-Up by Race and Ethnicity of 36,390 Patients in the T1Dx-QI Collaborative - EBEKOZIEN O, NOOR N, KAMBOJ MK, et al. Diabetes
  Introduction: The multi-center T1D Exchange QI Collaborative (T1DX-QI) is a learning health network sharing de-identified electronic medical record data for type 1 diabetes (T1D) care improvement.Objectives: To investigate trends in racial and ethnic inequities in glycemic outcomes in children (...)
• 02:00
  168-LB: Presentation of New Onset Diabetes in Youth during the COVID-19 Pandemic - CITRON K, STEIN CR, ILKOWITZ J, et al. Diabetes
  Background: Early research suggests during the COVID-19 pandemic there was an increase in new onset diabetes mellitus (DM) and greater severity at presentation. We examined pandemic related trends of new onset DM among patients at a pediatric diabetes center in New York, NY.Methods: We (...)
• 02:00
  168-OR: Patterns of Continuous Glucose Monitoring Utilization in Adults with Type 1 Diabetes, 2016–2019 - LEE KE, FOWLKES J, LACY ME. Diabetes
  Background: Continuous glucose monitoring (CGM) improves diabetes control by reducing HbA1c and decreasing rates of hypoglycemia. Despite clinical benefits and clear guidelines from the American Diabetes Association, 365 days of continuous eligibility were followed from their first (...)
• 02:00
  169-LB: Structural Echocardiographic Abnormalities in T2D —Mexico Cohort of Take Care of Me Program - SAHAGUN-SANCHEZ G, GUTIÉRREZ-FAJARDO P, MEZA-LEDEZMA O, et al. Diabetes
  Rationale: Due to gaps in detecting subclinical cardiac abnormalities in T2D, we evaluated prevalence and clinical manifestations of early echocardiographic (echo) abnormalities in primary care in Mexico.Methods: Mexico cohort of the ongoing ‘Take CaRe of Me program’ enrolled 2760 people with T2D (...)
• 02:00
  186-LB: Relationship of the Diagnosis of Diabetes Mellitus (DM) and Hyperglycemia without DM Diagnosis at Hospital Admission with the Evolution of Patients Hospitalized for COVID-19 in a Private Hospital Center in Asunción-Paraguay - CANATA MG, LOGWIN SA, BUENO COLMAN ED, et al. Diabetes
  Aim: To analyze the relationship between diagnosis of DM, Hyperglycemia of hospital admission and evolution of patients hospitalized for COVID-19 in the Sanatorium “Las Lomas” Asunción, Paraguay. Materials and methods: Observational, analytical, case-control, retrospective design. Total (...)
• 02:00
  186-OR: Novel Autoantibodies to Deamidated IA2 Extracellular Domain in Type 1 Diabetes - JIA X, MIAO D, ZHANG C, et al. Diabetes
  Background: Insulinoma antigen-2 (IA2) is a major self-antigen in T1D with post translational modification (PTM) of the extracellular domain (IA2ec) by deamidation eliciting T cell responses in T1D patients. Yet the autoantibodies (Abs) to these IA2ec PTM epitopes in T1D has not been (...)
• 02:00
  187-LB: Leveling Health Disparities through Digital Health—Associations between Risk for Health Inequity and Diabetes App Satisfaction, Use, and Outcomes - IMRISEK SD, NAGRA H, HOY-ROSAS JR, et al. Diabetes
  Introduction: Disparities in health outcomes are well documented in the literature, with factors such as race, education and income increasing the risk of inequity. Mobile health (mHealth) may help bridge the health equity gap. This study investigates use and attitudes toward One Drop's mHealth (...)
• 02:00
  187-OR: Declines in ß-Cell Glucose Responsiveness Correlate with Loss of Glucose Metabolism during T1D Pathogenesis - HUBER M, RUPNIK M, DROTAR DM, et al. Diabetes
  Features of type 1 diabetes (T1D) include loss of first-phase insulin secretion in response to glucose, declining c-peptide, and glucose intolerance; indicating ? cell dysfunction. Here, we investigate the mechanisms of this dysfunction with the hypothesis that immune dysregulation during the (...)
• 02:00
  275-OR: Inhibition of Hepatic ACC Decreases Ketogenesis during Fasting due to Elevated Amino Acid Availability - DEJA S, FLETCHER JA, KUCEJOVA B, et al. Diabetes
  Activation of fatty acid oxidation is a promising therapy for NAFLD. Lowering acetyl-CoA carboxylase (ACC) activity depletes malonyl-CoA, activates CPT1, and increases mitochondrial fatty acid delivery. ACC1/2 liver double KO mice (LDKO) are protected from hepatic steatosis and have elevated (...)
• 02:00
  276-OR: Impaired Glucagon-Mediated Suppression of VLDL-TG Secretion in Individuals with MAFLD - HEEBØLL S, RISIKESAN JR, GRONBAEK H, et al. Diabetes
  Background: Individuals with Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) have both elevated triglyceride and glucagon levels, although glucagon suppresses the very-low-density lipoprotein-triglyceride (VLDL-TG) secretion in lean individuals. Therefore, we hypothesized that the (...)
• 02:00
  277-OR: Increased Liver Fat Is Associated with Severe Metabolic Perturbations in Men Born with a Low Birth Weight - ELINGAARD-LARSEN L, JUSTESEN L, VILLUMSEN SO, et al. Diabetes
  Background: Ectopic fat deposition resulting from impaired subcutaneous adipose tissue expandability may take center stage in the pathophysiological events linking low birth weight (LBW) with increased risk of developing Type 2 diabetes (T2D) . However, the extent to which adult LBW subjects (...)
• 02:00
  278-OR: ADA Presidents' Select Abstract: Impact of Overnight Blood Glucose on Next-Day Functioning in T1D - PYATAK E, SPRUIJT-METZ D, SCHNEIDER S, et al. Diabetes
  Introduction: While people with T1D report that blood glucose (BG) fluctuations affect their day-to-day functioning, these relationships are poorly understood. Using continuous glucose monitoring (CGM) , accelerometry, and momentary surveys and cognitive tasks, we sought to understand how (...)
• 02:00
  279-OR: Self-Efficacy, Diabetes Distress, Self-Care, and Blood Glucose: Within-Person Pathways in Adults with T1D - GONZALEZ JS, SPRUIJT-METZ D, SCHNEIDER S, et al. Diabetes
  Introduction: Research links self-efficacy and diabetes distress to suboptimal diabetes self-care and blood glucose (BG) regulation. However, most studies rely on between-person comparisons that cannot rule out confounding by unmeasured variables or capture the dynamic interplay among these (...)
• 02:00
  27-LB: Prevalence and Severity of Diabetic Retinopathy in African Americans with End-Stage Kidney Disease - EGEOLU M, MANISHIMWE E, ZABALA ZE, et al. Diabetes
  Background and Methods: This cross-sectional study determined the prevalence of diabetic retinopathy (DR) in non-Hispanic African Americans (AA) with end-stage-kidney disease (ESKD) and their impact on quality of life. A total of 95 adults with type 1 (n= 10) and type 2 (n= 85) on dialysis (...)
• 02:00
  482-P: Do Varied Off-Loading Modalities Have Differing Impacts Upon Users' Fall Risk? - CREWS RT, ROSENBLATT NJ. Diabetes
  Aim: Adherence to offloading devices for diabetic foot ulcers (DFU) is poor and postural instability influences adherence. Prior research suggests an ankle-high removable cast walker (RCW) in tandem with a contralateral shoe lift might increase users’ balance relative to a traditional knee-high (...)
• 02:00
  483-P: Predictors of Major Adverse Lower Limb Events for Chronic Arterial Trophic Disorders - VOSGIN-DINCLAUX V, MOHAMMEDI K, CARADU C. Diabetes
  Background: Peripheral arterial disease (PAD) affects more than 200 million people with an ever-increasing prevalence. Faced with this public health issue, it seems crucial to take an interest in PAD management. In this study, we evaluated the predictors of major adverse lower limb events (...)
• 02:00
  134-OR: Cost-Effectiveness of a Real-Time Continuous Glucose Monitoring System vs. Self-Monitoring of Blood Glucose in Type 2 Diabetes Patients on Insulin in Canada - ISITT JJ, ROZE S, COGSWELL G, et al. Diabetes
  A health economic analysis was conducted to determine the cost-effectiveness of a real-time continuous glucose monitoring (rt-CGM) system versus self-monitoring of blood glucose (SMBG) in Type 2 diabetes (T2D) patients treated with insulin. The IQVIA CORE diabetes model was utilized for the (...)
• 02:00
  152-OR: Evidence Linking Loss of Hypothalamic Perineuronal Nets to Obesity Pathogenesis - ALONGE KM, DORFMAN MD, SCARLETT JM, et al. Diabetes
  Defective neurocircuit activity within the hypothalamic arcuate nucleus (ARC) , a crucial brain area for the regulation of metabolism, is implicated in obesity pathogenesis. Perineuronal nets (PNNs) are extracellular matrix structures that regulate neurocircuit activity, and PNN loss can (...)
• 02:00
  153-LB: Type 1 Diabetes (T1D) Onset and COVID-19—Effect of the Second Wave on Diabetes Ketoacidosis and ICU Admission Rates in Newly Diagnosed Children with T1D in Kuwait - OTHMAN F, AL-ABDULRAZZAQ D, ALKANDARI H. Diabetes
  Introduction: The COVID-19 pandemic had affected access to healthcare services around the globe. On February 24th, 2020, the first wave of the pandemic was announced. The government of Kuwait had implemented public health measures including curfews, nationwide lockdowns, and limited access to (...)
• 02:00
  153-OR: Ventromedial Hypothalamic Nucleus Controls Glucose Metabolism through Adipose Tissue Lipolysis - AFFINATI A, FLAK J, KODUR N, et al. Diabetes
  The central nervous system (CNS) coordinates metabolic target organ function to optimize blood glucose levels, while dysregulation of this system leads to impaired glycemia. Attempts to improve glucose control through CNS targeting are hindered by a incomplete understanding of the specific (...)
• 02:00
  154-LB: Population-Based Optimization of Metabolic Monitoring for Autoantibody-Positive Individuals at Risk for Type 1 Diabetes - OROURKE C, SPEAKE C, YLESCUPIDEZ A, et al. Diabetes
  Diabetic ketoacidosis (DKA) is often the sentinel event to a diagnosis of clinical type 1 diabetes. Research studies involving antibody positive (AAB+) individuals at risk for developing type 1 diabetes have demonstrated that metabolic monitoring every 6 months with oral glucose tolerance (...)
• 02:00
  205-OR: Nutrient Sensor OGT Regulates Glucose Homeostasis through ß-Cell Autophagy via mTORC1 Pathway - JO S, ALEJANDRO E. Diabetes
  A key aspect of type 2 diabetes (T2D) is the failure of ?-cells to secrete sufficient insulin to tightly control blood glucose. Nutrient sensor mTORC1 balances cell growth and degradative process (autophagy) to maintain ?-cell health and function. Changes to mTORC1 activity and autophagy are (...)
• 02:00
  206-LB: Increase of Hexokinase-2 Protein without Increase of Other Glycolytic Enzymes in Myotubes with High Glucose Concentration Supports the Hypothesis of Hexokinase-2-Linked Unscheduled Glycolysis as a Driver of Insulin Resistance - XUE M, RABBANI N, THORNALLEY P. Diabetes
  Insulin resistance in skeletal muscle is the major metabolic defect leading to the development of type 2 diabetes. The initiating dysfunction driving development of insulin resistance has not been disclosed. Recently, stabilization of hexokinase-2 (HK2) to proteolysis by increased glucose (...)
• 02:00
  27-OR: Fatty Acid Uptake and Metabolism in Human Adipose Tissue Is Decreased upon Consuming an Isocaloric High–Saturated Fat Diet and Partially Genetically Determined - KRUSE M, OST A, HORNEMANN S, et al. Diabetes
  CD36 transports fatty acids (FA) into adipocytes and is increased in white adipose tissue (WAT) in obesity. In rodents, however, it was shown that CD36 knock out is protective for diet induced adiposity. In humans a hypocaloric high fat diet decreased CD36 gene expression in WAT. This study (...)
• 02:00
  280-OR: Updated Diabetes Family Conflict Scale (DFC) Includes Continuous Glucose Monitoring (CGM) Items - CHEN C, SHAPIRA A, VOLKENING LK, et al. Diabetes
  Introduction: With increased CGM use in youth with T1D, it is timely to assess diabetes-specific family conflict related to CGM use. We aimed to evaluate the psychometric properties of an updated DFC measure that includes CGM items.Methods: Youth with T1D and their parents completed youth and (...)
• 02:00
  281-OR: Psychosocial Benefits of Using Control-IQ Technology: Long-Term Outcomes from a Multiethnic Adult Cohort with Type 1 Diabetes - SINGH H, ALENCAR G, SANCHEZ H, et al. Diabetes
  There is mounting evidence supporting the benefits of hybrid closed loop systems for type 1 diabetes (T1D) management. However, published studies lack long-term evaluation of these technologies in ethnically diverse patients including patient-reported outcomes (PROs) assessing lived experiences (...)
• 02:00
  282-OR: The Emotional Burden of Diabetes during Emerging Adulthood: “Cost. Everything Else Is Secondary.” - VITALE RJ, WENTZELL K, LAFFEL LM. Diabetes
  Emerging adults (EA) with type 1 diabetes (T1D) have multiple developmental stage-specific challenges in diabetes management, including the transition to financial independence. The recently validated Problem Areas in Diabetes-EA (PAID-EA) survey is the first measure of diabetes distress (DD) (...)
• 02:00
  283-OR: Neighborhood Disadvantage for Teens with Type 1 Diabetes (T1D) : Associations with Glycemic and Psychosocial Outcomes - O'DONNELL MB, DURAN B, ZHOU C, et al. Diabetes
  Background: For teens with T1D, stress related to neighborhood disadvantage may exacerbate diabetes distress and contribute to disparities in care and outcomes.Objective: We explored associations among neighborhood disadvantage and clinical/psychosocial outcomes to identify patterns to inform (...)
• 02:00
  284-OR: Diabetes Technology Access for Youth with T1D and High Social Risk: Comparing Intervention Outcomes - LELY J, HARRIS MA, NARANJO D, et al. Diabetes
  Objective: Health disparities exist in diabetes technology access for those youth with T1D who experience high social risk, despite likely benefits. Novel Interventions in Children’s Healthcare (NICH) , designed to improve health for youth with T1D experiencing such disparities, has previously (...)
• 02:00
  286-OR: The CREATE Trial: Randomized Clinical Trial Comparing Open-Source Automated Insulin Delivery with Sensor Augmented Pump Therapy in Type 1 Diabetes - BURNSIDE MJ, LEWIS DM, CROCKET H, et al. Diabetes
  Objective: Open-source automated insulin delivery (AID) pre-dated the availability of commercial systems and is used by thousands of people with T1D despite no regulatory approval. Our objective was to examine efficacy and safety of open-source AID.Methods: A 24 week, multi-center RCT in (...)
• 02:00
  287-OR: Eliminating Manual Meal Bolusing: A Feasibility Trial Using MiniMed 780G and Hand Gesture Algorithms - ROY A, GROSMAN B, MILLER D, et al. Diabetes
  Background: Carb-counting is a significant burden for persons with diabetes who require insulin to mitigate postprandial hyperglycemia. A closed-loop (CL) system with auto meal-bolus that eliminates manual mealtime bolusing was studied in adults with T1D.Methods: The system included the (...)
• 02:00
  288-OR: Effect of 24 Months of Optimised Glucose Control on Residual C-Peptide Secretion in Youth with New Onset Type 1 Diabetes (T1D) - BOUGHTON CK, WARE J, ALLEN JM, et al. Diabetes
  Background: We assessed whether improved glucose control with hybrid closed loop can preserve C-peptide secretion compared to standard insulin therapy in youth with T1D.Methods: In a multicentre, randomised, parallel trial, youth aged to DisclosureC.K. Boughton: Consultant; CamDiab Ltd. J. (...)
• 02:00
  542-P: Determinants of Objectively Measured Physical Activity in Chinese Immigrants in the U.S. with Prior Gestational Diabetes - HUANG S, ASH GI, NAM S, et al. Diabetes
  Background: Women with prior gestational diabetes (GD) have times the risk of developing type 2 diabetes (T2D) as women without prior GD. Chinese immigrants in the US are disproportionately affected by GD and T2D. Physical activity (PA) is a modifiable lifestyle strategy to reduce the risk of (...)
• 02:00
  543-P: Interruptions in Cardiac Rehabilitation Sessions Are Disproportionately Higher in Patients with Diabetes - KHONG AA, JUNKER M, GIANCATERINO S, et al. Diabetes
  Background: The clinical benefits of cardiac rehabilitation (CR) are attendance related; hence, interruptions or cancellations (I/C) of CR sessions limit clinical effectiveness. However, data on the frequency of I/C in CR is sparse. In this study, we aim to characterize the prevalence and (...)
• 02:00
  544-P: Poor Glycemic Control Leads to Major Disruptions of Cardiac Rehabilitation - KHONG AA, GIANCATERINO S, JUNKER M, et al. Diabetes
  Background: We have shown that 50% of cardiac rehabilitation (CR) patients have at least one exercise session interrupted or cancelled (I/C) . These disruptions were highly correlated with a diabetes mellitus (DM) diagnosis. The aim of this study was to characterize the frequency of I/C at the (...)
• 02:00
  545-P: The Impact of Gender on Physical Activity Preferences and Barriers in Adults with Type 1 Diabetes: A Qualitative Study - LOGAN JE, PREVOST M, BRAZEAU A, et al. Diabetes
  Exercise studies involving people with type 1 diabetes (T1D) have tested young, fit, men. As such, current insulin adjustment and carbohydrate intake advice may not work for women. A recent secondary analysis found different blood glucose (BG) responses to a weight lifting protocol between male (...)
• 02:00
  546-P: Video Call-Based Assessment of Physical Fitness through Diabefly Digital Therapeutics Program for People with T2D in India - BHAGAT M, MANDLEKAR AS, VERMA R, et al. Diabetes
  Background: Exercise is an integral aspect for effective diabetes management. Supervised home-based exercise through exercise prescriptions customized based on a person's exercise status, pain complaints and fitness levels can help in better adherence and low risk of injury while reducing (...)
• 02:00
  547-P: Changes in Body Weight and Glucoregulatory Markers by Eight-Hour Time-Restricted Eating vs. Daily Calorie Restriction: A 6-Month Randomized Controlled Trial - CIENFUEGOS S, LIN S, GABEL K, et al. Diabetes
  Background: Intermittent fasting has gained substantial popularity in the past decade. The most popular form of intermittent fasting is time restricted eating (TRE) , which involves eating within a 4-to-10-hour window and water fasting for the rest of the day. Short-term studies (2 months) (...)
• 02:00
  548-P: Food Insecurity during COVID-Is Associated with Worse Outcomes among People with Type 2 Diabetes - STEVENSON J, GOWEN R, YE E, et al. Diabetes
  Background: Low food security is associated with increased barriers to diabetes management, and COVID-has exacerbated food insecurity in the United States. This study assessed correlation between food insecurity and health outcomes among people with type 2 diabetes (T2D) during the first year (...)
• 02:00
  549-P: A Premeal Drink of Low-Dose Whey Protein (WP) Microgel Rapidly Increases Bioavailability of Branched Chain Amino Acids (BCAA) in People with Type 2 Diabetes (T2D) : A Randomized, Placebo-Controlled Crossover Study - NEELAND I, AHRÉN B, CORTHÉSY JV, et al. Diabetes
  BCAAs are key ingredients of WPs with biomodulatory effects. We recently reported that a highly-concentrated low-dose (10g, 40 Cal) WP pre-meal drink (125 mL) , generated with novel micelle-technology (WP microgel [WPM]) , ingested 15 min ahead of a pizza-meal (622 Cal) , vs placebo (PBO) , (...)
• 02:00
  54-LB: Distinct Mechanisms Are Responsible for the Increase in Endogenous Glucose Production and Ketone Formation following Empagliflozin in T2DM Patients - ABDELGANI S, ADAMS JM, III, DANIELE G, et al. Diabetes
  Aim: To examine the mechanisms responsible for the increase in glucose and ketone production caused by SGLT2 inhibition with empagliflozin in T2DM patients.Research Design and Methods: 12 T2DM subjects (Age = 53; BMI = 31.7; HbA1c = 7.4%) participated in two studies performed in random order. (...)
• 02:00
  54-OR: Psychosocial Factors and Medication Adherence in Young Adults with Youth-Onset Type 2 Diabetes: Longitudinal Results from the iCount Study - TRIEF PM, KALICHMAN S, USCHNER D, et al. Diabetes
  Aim: To identify psychosocial factors in young adults (mean age 26 yrs) that predict medication adherence 1 year later in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY2) observational study.Methods: Validated psychosocial measures (attitudes, beliefs, self-efficacy, (...)
• 02:00
  397-P: eGFR Changes from Adolescence into Young Adulthood in Type 1 Diabetes: Evaluation of Novel eGFR Formulae - BABALOLA F, SOCHETT EB, CURTIS J, et al. Diabetes
  Background: Diabetic kidney disease (DKD) is one of the leading causes of CKD and ESRD. Decline in eGFR represents an early marker of DKD that may precede microalbuminuria. The optimal eGFR formula during transition from adolescence into adulthood remains unclear.Objective: To assess (...)
• 02:00
  398-P: KIM-1 and TNFR 1 and Associations with Early Diabetic Nephropathy Histology - TIAN F, PRINCE D, DORIA A, et al. Diabetes
  Aim: GFR and urine albumin excretion (UAE) are prevailing measures used to detect and monitor diabetic nephropathy (DN) . We tested whether serum kidney injury molecule-1 (KIM-1) and tumor necrosis factor receptor-1 (TNFR1) , markers of DN progression, are associated with DN renal structural (...)
• 02:00
  399-P: Associations among Biomarkers of Inflammation, Tubular Injury, and Lipid Metabolism with Gestational Diabetes Mellitus (GDM) Status, Microalbuminuria, and Retinopathy in the MARIGOLD Study - LIU H, SRIDHAR VS, LOVBLOM L, et al. Diabetes
  Levels of hyperglycemia below those for diagnosis of diabetes are associated with microvascular injury, though the duration required to induce these complications remains poorly understood. This is especially relevant in patients with GDM due to its transient nature, which can nevertheless (...)
• 02:00
  39-LB: A Comparison of Insulin Glargine U300 and Insulin Degludec around Spontaneous Exercise Sessions in People with Type 1 Diabetes—The ULTRAFLEXI-1 Study - MOSER O, MUELLER A, ABERER F, et al. Diabetes
  Background and aims: Regular physical activity and exercise represent a corner stone in the treatment of type 1 diabetes (T1D) , however, exercise-induced hypoglycemia remains the major barrier to a physically active lifestyle. Therefore, the ULTRAFLEXI-1 study compared two basal insulin (...)
• 02:00
  39-OR: Improved Psychosocial and Quality of Life Measures in Children and Youth with Type 1 Diabetes Initiating Control-IQ Technology - ZUIJDWIJK CS, COURTNEY J, MITSAKAKIS N, et al. Diabetes
  Objective: To determine perceptions of the impact of Control-IQ™ technology (CIQ) on psychosocial functioning and quality of life (QoL) in children/ youth with T1D and their parents, using patient and parent reported outcome measures (PROMs) .Research Design and Methods: Single-center (...)
• 02:00
  3-LB: A Free-Living Walking-Based Exercise Programme Improves HbA1c in Individuals with Obesity, with Additional Benefits of Nutritional Status on Metabolic Health - BARRETT JS, SHEPHERD SO, WAGENMAKERS A, et al. Diabetes
  Background: Regular exercise improves insulin resistance and glycaemic control, but ‘real world’ programmes are not universally effective. Laboratory studies show that post-breakfast exercise improves postprandial glucose excursions with subsequent meals while pre-breakfast exercise augments (...)
• 02:00
  3-OR: Hepatocyte Gdf15 Is Sufficient for Increased Plasma GDF15 Levels and Body Weight Constraint during High-Fat–Diet Feeding and Restores Insulin Sensitivity in a Liver-Specific Manner - XIE B, MURALI A, VANDEVENDER A, et al. Diabetes
  Growth and differentiation factor 15 (GDF15) is a stress-induced secreted protein whose plasma levels are increased in obese patients. Recombinant GDF15 reduces body weight (BW) and improves glycemia in obese models, which is largely attributed to central action of GDF15 to suppress feeding. (...)
• 02:00
  400-P: More Pronounced Effect of Empagliflozin-Losartan Combination Therapy on Measured GFR and Blood Pressure vs. Either of the Drugs: A Crossover RCT in People with Type 2 Diabetes - VAN RAALTE D, HEERSPINK HL, SCHOLTES R. Diabetes
  Introduction: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) and renin-angiotensin system inhibitors (RASi) improve kidney outcomes in people with type 2 diabetes (T2D) . Both drugs favorably affect kidney hemodynamic function which is characterized an acute GFR drop (reflecting reduced (...)
• 02:00
  401-P: Development of Predictive Models for Health Care Outcomes of Patients with Chronic Kidney Disease and Type 2 Diabetes - SHEER R, NAIR R, PASQUALE MK, et al. Diabetes
  Progression of chronic kidney disease (CKD) is associated with increased risk of cardiovascular or renal events that contribute to increasing healthcare costs. The purpose of this study was to develop predictive models for rapid progression of CKD, days out of the home, and high costs for (...)
• 02:00
  402-P: Machine Learning Approach to Evaluate the Prospective Kidney Failure Risk of the Complement Proteome in T1D - DOM Z, MOON S, PICKETT S, et al. Diabetes
  We tested the Complement proteome’s prognostic accuracy for kidney outcomes in T1D using a machine learning (ML) approach.Methods: This prospective cohort study comprised 193 Joslin Kidney Study subjects with T1D and an overt diabetic kidney disease at baseline followed for years. We performed (...)
• 02:00
  403-P: Reduced Mitochondrial DNA Copy Number in Type 1 Diabetes and Nephropathy and Correlates Thereof - JANUSZEWSKI AS, CARROLL L, LOH YW, et al. Diabetes
  Background: Mitochondrial DNA (Mt-DNA) copy number (mtDNA-CN) has been proposed as a marker of diabetic kidney disease (DKD) . Most studies are in type 2 diabetes. We determined mtDNA-CN in adults with type 1 diabetes vs. non-diabetic subjects, including associations with complications and risk (...)
• 02:00
  404-P: Relationships among Triglyceride (TG) Concentrations across Lipoprotein Subclasses, Intraglomerular Hemodynamics, and Kidney Oxygen Availability in Adolescents with Type 1 Diabetes (T1D) - PAULEY ME, TOMMERDAHL KL, VINOVSKIS C, et al. Diabetes
  TG concentrations across lipoprotein subclasses associate with diabetic kidney disease (DKD) in adults with T1D, but little is known about this relationship in youth with T1D. We evaluated cross-sectional relationships among TG concentrations across lipoprotein subclasses, intraglomerular (...)
• 02:00
  649-P: Real-Time Continuous Glucose Monitoring in the Hospital Identifies and Prompts Treatment for Hypoglycemia - BAKER M, WELSH J. Diabetes
  Reliance on point-of-care (POC) blood glucose measurements for inpatient diabetes management can result in long between-measurement intervals, which contribute to undetected and untreated dysglycemia. The G6 real-time continuous glucose monitoring (RT-CGM) system (Dexcom) allows for remote (...)
• 02:00
  64-LB: Long-Term Effectiveness of the My Dose Coach Application on the Maintenance of Glycemic Control in Patients with Type 2 Diabetes Mellitus in Uncontrolled - POLANCO MA. Diabetes
  Introduction: My Dose Coach (MDC) is an app designed for basal insulin dose titration that has demonstrated its versatility in several clinical studies. We evaluated its effect on the maintenance of glycemic control for 28 weeks in patients with type 2 Diabetes.Objective: Compare the efficacy (...)
• 02:00
  64-OR: Reduction of HbA1c in Adults with Type 2 Diabetes through Sugarfit's Diabetes Reversal Program Using a Coach-Led, Technology-Enabled, and Habit-Based Approach: A Retrospective Analysis - MEHRA C, RAYMOND AM, PRABHU R, et al. Diabetes
  This study aimed to compare the changes in vital variables pertaining to type 2 diabetes (T2D) using Sugarfit’s Diabetes Reversal Program (SDRP) and a group with NO personal coach assistance. This is a retrospective analysis of people with T2D who participated in SDRP compared with those who (...)
• 02:00
  650-P: Artificial Intelligence and Individualized Optimal Glycemic Target in ICU Patients - YUN J, LEE G, KIM J, et al. Diabetes
  Introduction: Deep learning methods, commonly called artificial intelligence (AI) , have been widely adopted in medical research. Reinforcement learning is a particularly promising AI tool that can generate optimal strategies based on non-optimized training data. The aim of the currentstudy was (...)
• 02:00
  651-P: Continuous Glucose Monitoring in Primary Care: Explaining Characteristics Associated with CGM Prescription - OSER T, HALL T, WARMAN MK, et al. Diabetes
  Background: Continuous glucose monitors (CGM) provide clearer, more actionable data than self-monitoring of blood glucose and are associated with improved outcomes (e.g., reduced HbA1c) . Barriers to endocrinology care create disparities in CGM access. Expanding CGM use in primary care can (...)
• 02:00
  652-P: Gaps Remain in Achieving Target T1D Glycemic Goals Despite Advanced Technologies - LAFFEL LM, LIU J, TITIEVSKY L, et al. Diabetes
  Continuous glucose monitoring (CGM) metrics and self-reported disease characteristics (severe hypoglycemic events [SHEs], HbA1c) warrant further description in people with T1D using CGM and pumps, including hybrid closed-loop systems (HCLS) . We conducted a one-time online survey of adults with (...)
• 02:00
  653-P: Post-Breakfast Glycemic Profiles in Hispanic/Latino Adults with or at Risk of Type 2 Diabetes - PAI A, SANTIAGO RF, BEVIER WC, et al. Diabetes
  Hispanic/Latinos in the U.S. bear an excess burden of type 2 diabetes (T2D) . In type 1 diabetes and insulin-treated T2D, continuous glucose monitoring (CGM) is an established technology to guide therapy, yet CGM use and studies are rare in people with/at-risk of non-insulin treated T2D and (...)
• 02:00
  9-LB: Increased Islet Expression of Somatostatin and Glucagon in Male Rats with Insulin-Dependent Type 2 Diabetes - HOFFMAN EG, ATHERLEY SC, AKBARIAN N, et al. Diabetes
  Background: Pancreatic islet remodelling in type 1 diabetes increases somatostatin (SST) expression, which inhibits glucagon counterregulation to hypoglycemia. Here, we characterized islet morphology and hormone composition in a rodent model of insulin-deficient type 2 diabetes (T2D) .Methods: (...)
• 02:00
  9-OR: ADA Presidents' Select Abstract: m6A mRNA Methylation Regulates the Innate Immune Response in Human Beta Cells - DE JESUS DF, ZHANG Z, BROWN NK, et al. Diabetes
  Innate immunity is directly associated with Type 1 diabetes (T1D) . Recently, N6-methyladenosine (m6A) has been shown to modulate human ?-cell biology and innate immunity. Here, we focused on the contribution of m6A in modulating T1D development. RNA-seq. in ?-cells revealed downregulation of the (...)
• 02:00
  1145-P: Individual SGLT2 Inhibitors and the Risk of Diabetic Ketoacidosis - ABRAHAMI D, D'ANDREA E, KIM SC, et al. Diabetes
  SGLT2 inhibitors (SGLT2i) are increasingly prescribed to treat type 2 diabetes (T2D) given their cardiovascular benefits. However, SGLT2i are known to increase the risk of diabetic ketoacidosis (DKA) , a rare yet serious outcome. It remains unclear whether individual SGLT2i are associated with (...)
• 02:00
  1146-P: SGLT2 Inhibitors and the Risk of Early Bladder Cancer Events - ABRAHAMI D, TESFAYE H, YIN H, et al. Diabetes
  SGLT2 inhibitors (SGLT2is) have been shown to reduce the risk of cardiovascular and mortality events in large cardiovascular outcome trials in patients with type 2 diabetes. However, their safety profile is controversial, with some trials reporting imbalances in bladder cancer events, all of (...)
• 02:00
  1147-P: Trends in Diabetes-Related Foot Disease Hospitalization, Revascularization, and Amputations in Australia 20to 2019 - QUIGLEY M, MORTON JI, LAZZARINI PA, et al. Diabetes
  Hospitalization for diabetes-related foot disease adds considerable burden for people living with diabetes and often leads to lower extremity amputation. We evaluated trends in the incidence of foot disease related hospital admission, revascularization and amputation procedures among people (...)
• 02:00
  1261-P: Is Glycemic Control Better in Adults with Type 1 Diabetes When Office Visits are Supplemented with Telehealth Visits? - TOSCHI E, ADAM A, SLYNE C, et al. Diabetes
  Objective: Since the COVID-pandemic began, instead of in-office care alone, many institutions implemented hybrid care (in-office + telemedicine) . It is not known if hybrid care is as effective as in-office visits in regards to achieving glycemic goals.Methods: Clinical characteristics of (...)
• 02:00
  1321-P: Reproductive Experience Impairs Warm Sensing in Female Mice - ZHANG N, HE Y, XU Y. Diabetes
  The maternal body experiences drastic alterations in energy balance during pregnancy and lactation, but little is known about the long-term metabolic changes after this reproductive experience. Here we systemically compared the metabolic phenotypes in reproductive experienced (RE) female mice (...)
• 02:00
  1322-P: Role of Macrophage NOD1 in Fat-Induced ß-Cell Dysfunction - RAHMAN S, YUNG J, ZHANG Y, et al. Diabetes
  In individuals with obesity, free fatty acids (FFA) are chronically raised resulting in ß-cell dysfunction, leading to type 2 diabetes (T2D) . Recent data implicate the role of inflammation in developing ß-cell dysfunction, which is in part mediated by nucleotide-oligomerization domain 1 (NOD1) , (...)
• 02:00
  1323-P: Insulin Secretion at Diabetes Remission in Obese Blacks Presenting with Diabetic Ketoacidosis - STEFANOVSKI D, OLADEJO O, UMPIERREZ GE, et al. Diabetes
  In obese Blacks presenting with diabetic ketoacidosis (DKA) at new-onset of diabetes, intensive insulin treatment improves ?-cell function so that ˜70% achieve near-normoglycemia remission (HbA1c < 7%, fasting blood glucose [BG]3 months. It is unknown whether glycemic measures and insulin (...)
• 02:00
  1324-P: Short-Term Effects of Glycemia-Lowering Medications on ß-Cell Function in the GRADE Study - RASOULI N, ALBU J, COHEN RM, et al. Diabetes
  Therapies that preserve ?-cell function and enhance glycemic control in type 2 diabetes are of great value. We examined ?-cell function in GRADE participants after one year of intervention with insulin glargine U-100, glimepiride, liraglutide or sitagliptin. Participants who remained on (...)
• 02:00
  1325-P: Modulation of Overnight Free Fatty Acid and Glucose Concentrations and Their Effect on Postprandial Islet Function and Glucose Metabolism - WELCH AA, SCHEMBRI WISMAYER D, EGAN AM, et al. Diabetes
  Individuals with prediabetes can be classified by fasting and glucose tolerance status. Previously we observed that elevated fasting Free Fatty Acids (FFA) are associated with Impaired Glucose Tolerance (IGT) and decreased ?-cell function (quantified as Disposition Index (DI)) . Impaired Fasting (...)
• 02:00
  141-OR: Associations between Type 2 Diabetes Partitioned/Process-Specific Polygenic Scores and Metabolic Traits - WEDEKIND LE, HSUEH W, KOBES S, et al. Diabetes
  Polygenic scores (PS) for type 2 diabetes (T2D) associate strongly with disease status. Since T2D is heterogenous, using “partitioned” PS (pPS) that capture distinct etiological processes may improve clinical utility. A previous study in Europeans identified 6 pPS from genetic clusters (GCs) (...)
• 02:00
  1420-P: Gestational Diabetes Glyburide Treatment and Glycemic Control: Associations with Risk of Subsequent Child Obesity - JOSEFSON JL, SUN B, GREENBERG M, et al. Diabetes
  Gestational diabetes mellitus (GDM) increases offspring obesity risk. GDM severity, treatment, glycemic control and postnatal feeding behaviors increase or alleviate child obesity risk. This study sought to evaluate GDM treatment (glyburide vs. diet) and glycemic control related to (...)
• 02:00
  1421-P: Long-Term Type 2 Diabetes Remission after Bariatric Surgery in Patients with and without Liver Steatosis - LAUTENBACH A, WERNECKE M, MEYHÖFER SM, et al. Diabetes
  Background: Nonalcoholic steatohepatitis (NASH) is considered the hepatic manifestation of insulin resistance. Therefore, we aimed to assess the association between biopsy-proven liver steatosis and long-term remission of type 2 diabetes (T2D) 8 years following different bariatric (...)
• 02:00
  147-LB: Effects of the COVID-19 Pandemic on Type 1 Diabetes Outcomes - GEISER L, PYLE L, VIGERS TB, et al. Diabetes
  As the COVID-19 pandemic has disrupted daily life, it is important to understand its effects on youth with T1D. The COVID-19 Exposure and Family Impact Survey (CEFIS) was used to examine COVID-19 effects on diabetes metrics in a pediatric T1D population.Parents of youth with T1D (n=108; mean (...)
• 02:00
  147-OR: Glucose Intolerance of Hereditary Progeria Werner Syndrome and Cellular Senescence in Their Adipose Tissue - SAWADA D, KATO H, MAEZAWA Y, et al. Diabetes
  Background: Werner syndrome (WS) is a hereditary premature aging disorder in which various signs of accelerated aging develop after puberty. These signs include gray hair, cataracts, diabetes, myocardial infarction, and malignant tumors. Patients with WS frequently show severe insulin (...)
• 02:00
  180-LB: Plasma miRNAs May Be Associated with Waist Circumference and Insulin Resistance among Women with Polycystic Ovary Syndrome—Pilot Study - WANDER P, ENQUOBAHRIE D, BAMMLER T, et al. Diabetes
  Background: Insulin resistance (IR) and central obesity are common in PCOS, but pathomechanisms for IR in PCOS are not established. Circulating microRNAs (miRNAs) are non-invasive biomarkers of tissue gene expression that may contribute to the pathogenesis of IR and central adiposity in (...)
• 02:00
  180-OR: Empagliflozin Does Not Affect Pancreatic Fat Content and Insulin Secretion in Humans with Prediabetes - HUMMEL J, MACHANN J, DANNECKER C, et al. Diabetes
  Introduction: Pancreatic fat accumulation is a potential pathogenic factor in type 2 diabetes. Evidence from hypocaloric diet indicates that reduction of pancreatic fat could contribute to an improvement in ß-cell function. There is no established pharmacological approach to reduce pancreatic (...)
• 02:00
  181-LB: Fracture Risk of Antidiabetic Agents in Type 2 Diabetes—A Network Meta-analysis - HSUAN TSAI W, KE KONG S, TSAI M. Diabetes
  Background: Diabetes is associated with greater risk of fracture. Our aim is to evaluate the correlation of different antidiabetic agents with the risk of fracture among subjects with type 2 diabetes.Methods: The literature search was conducted in PubMed, Embase, and ClinicalTrials.gov on 22 (...)
• 02:00
  181-OR: Sympathetic Activity in Patients with Type 2 Diabetes Mellitus Treated with Empagliflozin or Hydrochlorothiazide - HEUSSER K, TANK J, FISCHER A, et al. Diabetes
  Changes in sympathetic nervous system activity may contribute to beneficial effects of sodium glucose transporter (SGLT2) inhibition on cardiovascular outcomes. We hypothesized that SGLT inhibition with empagliflozin lowers sympathetic activity compared with hydrochlorothiazide (HCT) to discern (...)
• 02:00
  182-LB: Delayed Onset of Parkinson’s Disease among Type 2 Diabetes Subjects—Data from an Observational Study - COLOSIMO S, CEREDA E, DEL SORBO F, et al. Diabetes
  Background and aim: Parkinson's disease (PD) is a common neurodegenerative movement disorder. Treatment aims at symptoms control and prevention of complications. Although type 2 diabetes (T2D) is a well-established risk factor for cerebrovascular diseases, evidence is lacking with regards to (...)
• 02:00
  182-OR: Clinical Effects of SGLT2 Inhibitors in HNF1A-Diabetes (MODY3) : A Case Series - MAAGENSEN H, HAEDERSDAL S, KROGH J, et al. Diabetes
  Mutations in hepatocyte nuclear factor 1-alpha (HNF1A) cause HNF1A-diabetes (or maturity-onset diabetes of the young type 3 (MODY3)) . Treatment of HNF1A-diabetes is primarily based on sulphonylureas (SU) and secondarily insulins, glucagon-like peptide 1 receptor agonists (GLP1-RA) and (...)
• 02:00
  183-LB: High Daily Doses of Insulin in Type 2 Diabetes—Predictors beyond Weight - DURON TABORA J, AMBLEE A, TAHSIN B, et al. Diabetes
  In clinical practice, needing ? 200 units insulin/day is defined as severe insulin resistance. This study seeks to identify predictive characteristics of those with type 2 diabetes and severe insulin resistance (? 200 units insulin/day) vs. those using 200 units daily (high insulin users - HIU) (...)
• 02:00
  183-OR: Overcoming Immunological Barriers for “Off-the-Shelf” iPSC-Derived Islets - HU X, WHITE K, OLROYD AG, et al. Diabetes
  Improved differentiation protocols allow large-scale generation of induced pluripotent stem cell (iPSC) -derived islets. In order to make allogeneic “off-the-shelf” islets clinically useful and avoid rejection absent immunosuppression (IS) , they need to evade host immune responses, a property we (...)
• 02:00
  184-LB: Patient-Reported Outcomes (PROs) to Treatment in Type 1 Diabetes (T1D) from the International Diabetes Management Practices Study (IDMPS) - GAGLIARDINO JJ, ASCHNER P, ILKOVA HM, et al. Diabetes
  Introduction: Achieving optimal HbA1c in people with T1D requires good treatment acceptance and self-management.Methods: IDMPS is an international, observational study investigating care practices and clinical profiles of people with diabetes in developing countries. The present analysis of (...)