285 posts

26 January

Diabetologia http://link.springer.com/

00:00
CCR2-positive monocytes contribute to the pathogenesis of early diabetic retinopathy in mice Diabetologia

Abstract Aims/hypothesis Accumulating evidence suggests that leucocytes play a critical role in diabetes-induced vascular lesions and other abnormalities that characterise the early stages of diabetic retinopathy. However, the role of monocytes has yet to be fully investigated; therefore, we (...)
00:00
Do sex differences in paediatric type 1 diabetes care exist? A systematic review Diabetologia

Abstract Aims/hypothesis Sex differences are present in cardiovascular care and in outcomes among adults with type 1 diabetes mellitus, which typically commences in childhood. Whether sex influences care and outcomes in childhood is not known. This systematic review provides an overview of sex (...)

24 January

Diabetologia http://link.springer.com/

19 January

Diabetologia http://link.springer.com/

00:00
Environmental exposures are important for type 2 diabetes pathophysiology in sub-Saharan African populations Diabetologia

18 January

Diabetologia http://link.springer.com/

00:00
Risk of kidney disease following a pregnancy complicated by diabetes: a longitudinal, population-based data-linkage study among Aboriginal women in the Northern Territory, Australia Diabetologia

Abstract Aims/hypothesis The aim of this work was to investigate the risk of developing chronic kidney disease (CKD) or end-stage kidney disease (ESKD) following a pregnancy complicated by gestational diabetes mellitus (GDM) or pre-existing diabetes among Aboriginal women in the Northern (...)

17 January

Diabetologia http://link.springer.com/

00:00
Counter-regulatory responses to postprandial hypoglycaemia in patients with post-bariatric hypoglycaemia vs surgical and non-surgical control individuals Diabetologia

Abstract Aims/hypothesis Post-bariatric hypoglycaemia is an increasingly recognised complication of bariatric surgery, manifesting particularly after Roux-en-Y gastric bypass. While hyperinsulinaemia is an established pathophysiological feature, the role of counter-regulation remains unclear. (...)

14 January

Diabetologia http://link.springer.com/

00:00
Cardiovascular outcomes in type 1 and type 2 diabetes Diabetologia

Abstract Diabetes is one of the most prevalent cardiometabolic disorders on the planet. Type 1 diabetes accounts for only a minority of all cases (recently estimated to be ~2% globally); however, since this is a disorder with an early onset, many people live with type 1 diabetes for a long (...)
00:00
Congenital malformations among offspring of women with type 1 diabetes who use insulin pumps: a prospective cohort study Diabetologia

Abstract Aims/hypothesis Continuous subcutaneous insulin infusion by insulin pump is often superior in improving glycaemic control compared with conventional multiple daily insulin injection (MDI). However, whether pump treatment leads to improved pregnancy outcomes in terms of congenital (...)
00:00
Missing the forest-plot for the trees Diabetologia

Abstract Systematic reviews and meta-analyses are methods increasingly used in biomedical research since their introduction in the 1970s. They serve to replace other non-systematic and cherry-picked narrative reviews, which are highly variable in their approach, structure and content. Their (...)

12 January

Diabetologia http://link.springer.com/

00:00
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression Diabetologia

Abstract Aims/hypothesis Genome-wide studies have uncovered multiple independent signals at the RREB1 locus associated with altered type 2 diabetes risk and related glycaemic traits. However, little is known about the function of the zinc finger transcription factor Ras-responsive element (...)

11 January

Diabetologia http://link.springer.com/

00:00
Determination of autoantibodies in type 2 diabetes: one simple way to improve classification Diabetologia

Abstract This letter aims to increase interest in better classification of type 2 diabetes. This can be done in a simple and cheap way via determination of autoantibodies. Autoantibody analysis can be used to detect the 7–12% of people with diabetes that is phenotypic of type 2 diabetes but is, (...)
00:00
Prospective randomised placebo-controlled trial assessing the efficacy of silver dressings to enhance healing of acute diabetes-related foot ulcers Diabetologia

Abstract Aims/hypothesis Silver dressings are used for their antimicrobial properties but there is limited evidence of clinical benefit when managing diabetes-related foot ulcers (DFUs). We aimed to assess whether silver dressings in acute DFUs increased the proportion of ulcers healed (...)

2 January

Diabetologia http://link.springer.com/

14:20
Women in diabetes research: we can do better. Reply to Bonnefond A [letter] Diabetologia
14:20
Diabetes and the COVID-19 pandemic Diabetologia

Abstract Almost immediately after the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus emerged, it was evident that people with chronic diseases, including diabetes, were disproportionately affected, with an increased risk of hospitalisation and mortality. Over the ensuing 2 (...)
14:20
The impact of population-level HbA1c screening on reducing diabetes diagnostic delay in middle-aged adults: a UK Biobank analysis Diabetologia

Abstract Aims/hypothesis Screening programmes can detect cases of undiagnosed diabetes earlier than symptomatic or incidental diagnosis. However, the improvement in time to diagnosis achieved by screening programmes compared with routine clinical care is unclear. We aimed to use the UK Biobank (...)
14:20
The European Diabetes Forum (EUDF): a forum for turning the tide on diabetes in Europe Diabetologia
14:20
Global trends in the incidence of hospital admissions for diabetes-related foot disease and amputations: a review of national rates in the 21st century Diabetologia

Abstract Aims/hypothesis Diabetic foot disease (DFD) is a leading cause of hospital admissions and amputations. Global trends in diabetes-related amputations have been previously reviewed, but trends in hospital admissions for multiple other DFD conditions have not. This review analysed the (...)
14:20
Hepatic Acat2 overexpression promotes systemic cholesterol metabolism and adipose lipid metabolism in mice Diabetologia

Abstract Aims/hypothesis Acetyl coenzyme A acetyltransferase (ACAT), also known as acetoacetyl-CoA thiolase, catalyses the formation of acetoacetyl-CoA from acetyl-CoA and forms part of the isoprenoid biosynthesis pathway. Thus, ACAT plays a central role in cholesterol metabolism in a variety (...)
14:20
The incidence of childhood-onset type 1 diabetes, time trends and association with the population composition in Sweden: a 40 year follow-up Diabetologia

Abstract Aims/hypothesis During the 1980s and 1990s, the incidence of childhood-onset type 1 diabetes more than doubled in Sweden, followed by a plateau. In the present 40 year follow-up, we investigated if the incidence remained stable and whether this could be explained by increased (...)
14:20
The relationship between islet autoantibody status and the genetic risk of type 1 diabetes in adult-onset type 1 diabetes Diabetologia

Abstract Aims/hypothesis The reason for the observed lower rate of islet autoantibody positivity in clinician-diagnosed adult-onset vs childhood-onset type 1 diabetes is not known. We aimed to explore this by assessing the genetic risk of type 1 diabetes in autoantibody-negative and -positive (...)
14:20
MicroRNA biomarkers of type 2 diabetes: evidence synthesis from meta-analyses and pathway modelling Diabetologia

Abstract Aims/hypothesis MicroRNAs are being sought as biomarkers for the early identification of type 2 diabetes. This study aimed to synthesise the evidence from microRNA–type 2 diabetes association studies and microRNA-regulated type 2 diabetes pathway delineation studies that met stringent (...)
14:20
Preclinical exploration of combined glucagon inhibition and liver-preferential insulin for treatment of diabetes using in vitro assays and rat and mouse models Diabetologia

Abstract Aims/hypothesis Normalisation of blood glucose in individuals with diabetes is recommended to reduce development of diabetic complications. However, risk of severe hypoglycaemia with intensive insulin therapy is a major obstacle that prevents many individuals with diabetes from (...)
14:20
Investigating the causal relationships between excess adiposity and cardiometabolic health in men and women Diabetologia

Abstract Aims/hypothesis Excess adiposity is differentially associated with increased risk of cardiometabolic disease in men and women, according to observational studies. Causal inference studies largely assume a linear relationship between BMI and cardiometabolic outcomes, which may not be (...)
14:20
Importance of beta cell mass for glycaemic control in people with type 1 diabetes Diabetologia

Abstract Aims/hypothesis The role of beta cell mass in the balance of glucose control and hypoglycaemic burden in people with type 1 diabetes is unclear. We applied positron emission tomography (PET) imaging with radiolabelled exendin to compare beta cell mass among people with type 1 diabetes (...)
14:20
Intra-islet insulin synthesis defects are associated with endoplasmic reticulum stress and loss of beta cell identity in human diabetes Diabetologia

Abstract Aims/hypothesis Endoplasmic reticulum (ER) stress and beta cell dedifferentiation both play leading roles in impaired insulin secretion in overt type 2 diabetes. Whether and how these factors are related in the natural history of the disease remains, however, unclear. Methods In this (...)
14:20
Outdoor light at night in relation to glucose homoeostasis and diabetes in Chinese adults: a national and cross-sectional study of 98,658 participants from 162 study sites Diabetologia

Abstract Aims/hypothesis Exposure to artificial light at night (LAN) disrupts the circadian timing system and might be a risk factor for diabetes. Our aim was to estimate the associations of chronic exposure to outdoor LAN with glucose homoeostasis markers and diabetes prevalence based on a (...)
14:20
Correction to: Effects of long-term exercise on plasma adipokine levels and inflammation-related gene expression in subcutaneous adipose tissue in sedentary dysglycaemic, overweight men and sedentary normoglycaemic men of healthy weight Diabetologia
14:20
Up Front Diabetologia
14:20
Women in diabetes research: we can do better Diabetologia

24 December

Diabetologia http://link.springer.com/

12:36
Quantifying the utility of islet autoantibody levels in the prediction of type 1 diabetes in children Diabetologia

Abstract Aims/hypothesis The aim of this study was to explore the utility of islet autoantibody (IAb) levels for the prediction of type 1 diabetes in autoantibody-positive children. Methods Prospective cohort studies in Finland, Germany, Sweden and the USA followed 24,662 children at (...)
12:36
The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations Diabetologia

Abstract Aims/hypothesis We examined the contribution of rare HNF1A variants to type 2 diabetes risk and age of diagnosis, and the extent to which their impact is affected by overall genetic susceptibility, across three ancestry groups. Methods Using exome sequencing data of 160,615 (...)
12:36
Hyperbaric oxygen rapidly improves tissue-specific insulin sensitivity and mitochondrial capacity in humans with type 2 diabetes: a randomised placebo-controlled crossover trial Diabetologia

Abstract Aims/hypothesis Hyperbaric oxygen (HBO) therapy may improve hyperglycaemia in humans with type 2 diabetes, but underlying mechanisms are unclear. Our objective was to examine the glucometabolic effects of HBO on whole-body glucose disposal in humans with type 2 diabetes. Methods In a (...)
12:36
Milder loss of insulin-containing islets in individuals with type 1 diabetes and type 2 diabetes-associated TCF7L2 genetic variants Diabetologia

Abstract Aims/hypothesis TCF7L2 variants are the strongest genetic risk factor for type 2 diabetes. In individuals with type 1 diabetes, these variants are associated with a higher C-peptide AUC, a lower glucose AUC during an OGTT, single autoantibody positivity near diagnosis, particularly in (...)
12:36
Proteomic analysis of diabetes genetic risk scores identifies complement C2 and neuropilin-2 as predictors of type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) Study Diabetologia

Abstract Aims/hypothesis Genetic predisposition to type 2 diabetes is well-established, and genetic risk scores (GRS) have been developed that capture heritable liabilities for type 2 diabetes phenotypes. However, the proteins through which these genetic variants influence risk have not been (...)
12:36
Secular trend for increasing birthweight in offspring of pregnant women with type 1 diabetes: is improved placentation the reason? Diabetologia

Abstract Despite enormous progress in managing blood glucose levels, pregnancy in women with type 1 diabetes still carries risks for the growing fetus. While, previously, fetal undergrowth was not uncommon in these women, with improved maternal glycaemic control we now see an increased (...)
12:36
Factors associated with favourable 5 year outcomes in islet transplant alone recipients with type 1 diabetes complicated by severe hypoglycaemia in the Collaborative Islet Transplant Registry Diabetologia

Abstract Aims/hypothesis Islet transplantation has been studied in small cohorts of recipients with type 1 diabetes complicated by severe hypoglycaemic events (SHEs). We determined factors associated with favourable outcomes in a large cohort of recipients reported to the Collaborative Islet (...)
12:36
Targeted proteomics identifies potential biomarkers of dysglycaemia, beta cell function and insulin sensitivity in Black African men and women Diabetologia

Abstract Aims/hypothesis Using a targeted proteomics approach, we aimed to identify and validate circulating proteins associated with impaired glucose metabolism (IGM) and type 2 diabetes in a Black South African cohort. In addition, we assessed sex-specific associations between the validated (...)
12:36
Up Front Diabetologia
12:36
Metabolic traits affecting the relationship between liver fat and intrapancreatic fat: a mediation analysis Diabetologia

Abstract Aims/hypothesis The clinical importance of fat deposition in the liver and pancreas is increasingly recognised. However, to what extent deposition of fat in these two depots is affected by intermediate variables is unknown. The aim of this work was to conduct a mediation analysis with (...)
12:36
Changes in the gut bacteriome upon gluten-free diet intervention do not mediate beta cell preservation Diabetologia

Abstract Aims/hypothesis We previously detected indications that beta cell function is protected by gluten-free diet (GFD) introduced shortly after the onset of childhood type 1 diabetes. The present aim was to assess whether GFD was associated with changes in the gut bacteriome composition (...)
12:36
Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes Diabetologia

Abstract Aims/hypothesis Antibodies specific to oxidative post-translational modifications (oxPTM) of insulin (oxPTM-INS) are present in most individuals with type 1 diabetes, even before the clinical onset. However, the antigenic determinants of such response are still unknown. In this study, (...)
12:36
A new beta cell-specific mitophagy reporter mouse shows that metabolic stress leads to accumulation of dysfunctional mitochondria despite increased mitophagy Diabetologia

Abstract Aims/hypothesis Mitophagy, the selective autophagy of mitochondria, is essential for maintenance of mitochondrial function. Recent studies suggested that defective mitophagy in beta cells caused diabetes. However, because of technical difficulties, the development of a convenient and (...)
12:36
Loneliness increases the risk of type 2 diabetes: a 20 year follow-up – results from the HUNT study Diabetologia

Abstract Aims/hypothesis Type 2 diabetes is one of the leading causes of death globally and its incidence has increased dramatically over the last two decades. Recent research suggests that loneliness is a possible risk factor for type 2 diabetes. This 20 year follow-up study examined whether (...)
12:36
Ketones: the double-edged sword of SGLT2 inhibitors? Diabetologia

Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors are a class of medications used by individuals with type 2 diabetes that reduce hyperglycaemia by targeting glucose transport in the kidney, preventing its reabsorption, thereby inducing glucosuria. Besides improving HbA1c and reducing (...)
12:36
Automated insulin delivery: benefits, challenges, and recommendations. A Consensus Report of the Joint Diabetes Technology Working Group of the European Association for the Study of Diabetes and the American Diabetes Association Diabetologia

Abstract A technological solution for the management of diabetes in people who require intensive insulin therapy has been sought for decades. The last 10 years have seen substantial growth in devices that can be integrated into clinical care. Driven by the availability of reliable systems for (...)
12:36
Smoking, use of smokeless tobacco, HLA genotypes and incidence of latent autoimmune diabetes in adults Diabetologia

Abstract Aims/hypotheses Smoking and use of smokeless tobacco (snus) are associated with an increased risk of type 2 diabetes. We investigated whether smoking and snus use increase the risk of latent autoimmune diabetes in adults (LADA) and elucidated potential interaction with HLA high-risk (...)
12:36
Liver, visceral and subcutaneous fat in men and women of South Asian and white European descent: a systematic review and meta-analysis of new and published data Diabetologia

Abstract Aims/hypothesis South Asians have a two- to fivefold higher risk of developing type 2 diabetes than those of white European descent. Greater central adiposity and storage of fat in deeper or ectopic depots are potential contributing mechanisms. We collated existing and new data on the (...)
12:36
Hedgehog interacting protein activates sodium–glucose cotransporter 2 expression and promotes renal tubular epithelial cell senescence in a mouse model of type 1 diabetes Diabetologia

Abstract Aims/hypothesis Senescent renal tubular cells may be linked to diabetic kidney disease (DKD)-related tubulopathy. We studied mice with or without diabetes in which hedgehog interacting protein (HHIP) was present or specifically knocked out in renal tubules (HhipRT-KO), hypothesising (...)
12:36
Differential contribution of alpha and beta cell dysfunction to impaired fasting glucose and impaired glucose tolerance Diabetologia

Abstract Aims/hypothesis People with isolated impaired fasting glucose (IFG) have normal beta cell function. We hypothesised that an increased glucose threshold for beta cell secretion explains IFG. Methods We used graded glucose infusion to examine the relationship of insulin secretion rate (...)

1 August

Diabetologia http://link.springer.com/

00:00
Up Front Diabetologia
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Insulin allergy: a diagnostic and therapeutic strategy based on a retrospective cohort and a case–control study Diabetologia

Abstract Aims/hypothesis Insulin allergy is a rare but significant clinical challenge. We aimed to develop a management workflow by (1) validating clinical criteria to guide diagnosis, based on a retrospective cohort, and (2) assessing the diagnostic performance of confirmatory tests, based on (...)
00:00
Low- and middle-income countries demonstrate rapid growth of type 2 diabetes: an analysis based on Global Burden of Disease 1990–2019 data Diabetologia

Abstract Aims/hypothesis The study aims to quantify the global trend of the disease burden of type 2 diabetes caused by various risks factors by country income tiers. Methods Data on type 2 diabetes, including mortality and disability-adjusted life years (DALYs) during 1990–2019, were obtained (...)
00:00
Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes: results from the diabetes prevention study PREVIEW Diabetologia

Abstract Aims/hypothesis Lifestyle interventions are the first-line treatment option for body weight and cardiometabolic health management. However, whether age groups or women and men respond differently to lifestyle interventions is under debate. We aimed to examine age- and sex-specific (...)
00:00
IgM-associated gut bacteria in obesity and type 2 diabetes in C57BL/6 mice and humans Diabetologia

Abstract Aims/hypothesis IgM is the primary antibody produced by B cells and we hypothesise that IgM antibodies to gut microbiota may play a role in immunometabolism in obesity and type 2 diabetes. To test our hypothesis, we used B6 mice deficient in activation-induced cytidine deaminase (...)
00:00
Addition of intermittently scanned continuous glucose monitoring to standard care in a cohort of pregnant women with type 1 diabetes: effect on glycaemic control and pregnancy outcomes Diabetologia

Abstract Aims/hypothesis The aim of this study was to assess whether the addition of intermittently scanned continuous glucose monitoring (isCGM) to standard care (self-monitoring of blood glucose [SMBG] alone) improves glycaemic control and pregnancy outcomes in women with type 1 diabetes and (...)
00:00
Mediators of the association between educational attainment and type 2 diabetes mellitus: a two-step multivariable Mendelian randomisation study Diabetologia

Abstract Aims/hypothesis Type 2 diabetes mellitus is a major health burden disproportionately affecting those with lower educational attainment (EA). We aimed to obtain causal estimates of the association between EA and type 2 diabetes and to quantify mediating effects of known modifiable risk (...)
00:00
High levels of blood circulating immune checkpoint molecules in children with new-onset type 1 diabetes are associated with the risk of developing an additional autoimmune disease Diabetologia

Abstract Aims/hypothesis We assessed the levels of blood circulating immune checkpoint molecules (ICMs) at diagnosis of type 1 diabetes, and determined their association with the risk of developing an additional autoimmune disorder over time. Methods Children with new-onset type 1 diabetes (n (...)
00:00
Genetic risk of type 2 diabetes modifies the effects of a lifestyle intervention aimed at the prevention of gestational and postpartum diabetes Diabetologia

Abstract Aims/hypothesis The aim of this study was to assess the interaction between genetic risk and lifestyle intervention on the occurrence of gestational diabetes mellitus (GDM) and postpartum diabetes. Methods The RADIEL study is an RCT aimed at prevention of GDM and postpartum diabetes (...)
00:00
Lessons from single-cell RNA sequencing of human islets Diabetologia

Abstract Islet dysfunction is central in type 2 diabetes and full-blown type 2 diabetes develops first when the beta cells lose their ability to secrete adequate amounts of insulin in response to raised plasma glucose. Several mechanisms behind beta cell dysfunction have been put forward but (...)
00:00
Children at onset of type 1 diabetes show altered N-glycosylation of plasma proteins and IgG Diabetologia

Abstract Aims/hypothesis Individual variation in plasma N-glycosylation has mainly been studied in the context of diabetes complications, and its role in type 1 diabetes onset is largely unknown. Our aims were to undertake a detailed characterisation of the plasma and IgG N-glycomes in (...)
00:00
Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes: results from the diabetes prevention study PREVIEW Diabetologia

Abstract Aims/hypothesis Lifestyle interventions are the first-line treatment option for body weight and cardiometabolic health management. However, whether age groups or women and men respond differently to lifestyle interventions is under debate. We aimed to examine age- and sex-specific (...)
00:00
Health impact of seven herpesviruses on (pre)diabetes incidence and HbA1c: results from the KORA cohort Diabetologia

Abstract Aims/hypothesis The prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are seropositive for herpesviruses. This study examines the prospective association of herpesviruses with (pre)diabetes to evaluate their (...)
00:00
IgM-associated gut bacteria in obesity and type 2 diabetes in C57BL/6 mice and humans Diabetologia

Abstract Aims/hypothesis IgM is the primary antibody produced by B cells and we hypothesise that IgM antibodies to gut microbiota may play a role in immunometabolism in obesity and type 2 diabetes. To test our hypothesis, we used B6 mice deficient in activation-induced cytidine deaminase (...)
00:00
Risk of incident obstructive sleep apnoea in patients with type 1 diabetes: a population-based retrospective cohort study Diabetologia

Abstract Aims/hypothesis People with type 2 diabetes are at increased risk of developing obstructive sleep apnoea. However, it is not known whether people with type 1 diabetes are also at an increased risk of obstructive sleep apnoea. This study aimed to examine whether people with type 1 (...)
00:00
High levels of blood circulating immune checkpoint molecules in children with new-onset type 1 diabetes are associated with the risk of developing an additional autoimmune disease Diabetologia

Abstract Aims/hypothesis We assessed the levels of blood circulating immune checkpoint molecules (ICMs) at diagnosis of type 1 diabetes, and determined their association with the risk of developing an additional autoimmune disorder over time. Methods Children with new-onset type 1 diabetes (n (...)
00:00
Children at onset of type 1 diabetes show altered N-glycosylation of plasma proteins and IgG Diabetologia

Abstract Aims/hypothesis Individual variation in plasma N-glycosylation has mainly been studied in the context of diabetes complications, and its role in type 1 diabetes onset is largely unknown. Our aims were to undertake a detailed characterisation of the plasma and IgG N-glycomes in (...)

25 July

Diabetologia http://link.springer.com/

00:00
Islet amyloid polypeptide aggregation exerts cytotoxic and proinflammatory effects on the islet vasculature in mice Diabetologia

Abstract Aims/hypothesis The islet vasculature, including its constituent islet endothelial cells, is a key contributor to the microenvironment necessary for normal beta cell health and function. In type 2 diabetes, islet amyloid polypeptide (IAPP) aggregates, forming amyloid deposits that (...)
00:00
Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: a randomised crossover trial Diabetologia

Abstract Aims/hypothesis Time-restricted eating (TRE) is suggested to improve metabolic health by limiting food intake to a defined time window, thereby prolonging the overnight fast. This prolonged fast is expected to lead to a more pronounced depletion of hepatic glycogen stores overnight (...)

22 July

Diabetologia http://link.springer.com/

00:00
Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage Diabetologia

Abstract Aims/hypothesis Enteroviral infection has been implicated consistently as a key environmental factor correlating with the appearance of autoimmunity and/or the presence of overt type 1 diabetes, in which pancreatic insulin-producing beta cells are destroyed by an autoimmune response. (...)
00:00
Consortium-based approach to receiving an EMA qualification opinion on the use of islet autoantibodies as enrichment biomarkers in type 1 diabetes clinical studies Diabetologia

Abstract The development of medical products that can delay or prevent progression to stage 3 type 1 diabetes faces many challenges. Of note, optimising patient selection for type 1 diabetes prevention clinical trials is hindered by significant patient heterogeneity and a lack of (...)
00:00
Glycaemic thresholds for counterregulatory hormone and symptom responses to hypoglycaemia in people with and without type 1 diabetes: a systematic review Diabetologia

Abstract Aim/hypothesis The physiological counterregulatory response to hypoglycaemia is reported to be organised hierarchically, with hormone responses usually preceding symptomatic awareness and autonomic responses preceding neuroglycopenic responses. To compare thresholds for activation of (...)
00:00
Assessment of the bi-directional relationship between blood mitochondrial DNA copy number and type 2 diabetes mellitus: a multivariable-adjusted regression and Mendelian randomisation study Diabetologia

Abstract Aims/hypothesis Mitochondrial dysfunction, which can be approximated by blood mitochondrial DNA copy number (mtDNA-CN), has been implicated in the pathogenesis of type 2 diabetes mellitus. Thus far, however, insights from prospective cohort studies and Mendelian randomisation (MR) (...)
00:00
Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage Diabetologia

Abstract Aims/hypothesis Enteroviral infection has been implicated consistently as a key environmental factor correlating with the appearance of autoimmunity and/or the presence of overt type 1 diabetes, in which pancreatic insulin-producing beta cells are destroyed by an autoimmune response. (...)
00:00
Consortium-based approach to receiving an EMA qualification opinion on the use of islet autoantibodies as enrichment biomarkers in type 1 diabetes clinical studies Diabetologia

Abstract The development of medical products that can delay or prevent progression to stage 3 type 1 diabetes faces many challenges. Of note, optimising patient selection for type 1 diabetes prevention clinical trials is hindered by significant patient heterogeneity and a lack of (...)
00:00
Glycaemic thresholds for counterregulatory hormone and symptom responses to hypoglycaemia in people with and without type 1 diabetes: a systematic review Diabetologia

Abstract Aim/hypothesis The physiological counterregulatory response to hypoglycaemia is reported to be organised hierarchically, with hormone responses usually preceding symptomatic awareness and autonomic responses preceding neuroglycopenic responses. To compare thresholds for activation of (...)
00:00
Assessment of the bi-directional relationship between blood mitochondrial DNA copy number and type 2 diabetes mellitus: a multivariable-adjusted regression and Mendelian randomisation study Diabetologia

Abstract Aims/hypothesis Mitochondrial dysfunction, which can be approximated by blood mitochondrial DNA copy number (mtDNA-CN), has been implicated in the pathogenesis of type 2 diabetes mellitus. Thus far, however, insights from prospective cohort studies and Mendelian randomisation (MR) (...)

21 July

Diabetologia http://link.springer.com/

00:00
Associations of polysocial risk score, lifestyle and genetic factors with incident type 2 diabetes: a prospective cohort study Diabetologia

Abstract Aim/hypothesis We aimed to investigate the association between polysocial risk score (PsRS), an estimator of individual-level exposure to cumulative social risks, and incident type 2 diabetes in the UK Biobank study. Methods This study includes 319,832 participants who were free of (...)
00:00
Associations of polysocial risk score, lifestyle and genetic factors with incident type 2 diabetes: a prospective cohort study Diabetologia

Abstract Aim/hypothesis We aimed to investigate the association between polysocial risk score (PsRS), an estimator of individual-level exposure to cumulative social risks, and incident type 2 diabetes in the UK Biobank study. Methods This study includes 319,832 participants who were free of (...)

20 July

Diabetologia http://link.springer.com/

00:00
Up Front Diabetologia

19 July

Diabetologia http://link.springer.com/

00:00
ICAM-1 on the luminal surface of endothelial cells is induced to a greater extent in mouse retina than in other tissues in diabetes Diabetologia

Abstract Aims/hypothesis Induction of intercellular adhesion molecule-1 (ICAM-1) has been implicated in the development of macrovascular and microvascular diseases such as diabetic retinopathy. Lesions of diabetic retinopathy are unique to the retina but the reason for this is unclear, as all (...)
00:00
Retinal microvascular associations with cardiometabolic risk factors differ by diabetes status: results from the UK Biobank Diabetologia

Abstract Aims/hypothesis The aim of the study was to examine the association of retinal vessel morphometry with BP, body composition and biochemistry, and to determine whether these associations differ by diabetes status. Methods The UK Biobank ocular assessment included 68,550 participants (...)

18 July

Diabetologia http://link.springer.com/

00:00
Potential confounders in the association between per- and polyfluoroalkyl substance exposure and diabetes. Reply to Harada KH, Harada Sassa M [letter] Diabetologia

16 July

Diabetologia http://link.springer.com/

00:00
Potential confounders in the association between per- and polyfluoroalkyl substance exposure and diabetes Diabetologia

8 July

Diabetologia http://link.springer.com/

00:00
Glucose-mediated insulin secretion is improved in FHL2-deficient mice and elevated FHL2 expression in humans is associated with type 2 diabetes Diabetologia

Abstract Aims/hypothesis The general population is ageing, involving an enhanced incidence of chronic diseases such as type 2 diabetes. With ageing, DNA methylation of FHL2 increases, as well as expression of the four and a half LIM domains 2 (FHL2) protein in human pancreatic islets. We (...)
00:00
The efficacy of canagliflozin in diabetes subgroups stratified by data-driven clustering or a supervised machine learning method: a post hoc analysis of canagliflozin clinical trial data Diabetologia

Abstract Aims/hypothesis Data-driven diabetes subgroups have shown distinct clinical characteristics and disease progression, although there is a lack of evidence that this information can guide clinical decisions. We aimed to investigate whether diabetes subgroups, identified by data-driven (...)

1 July

Diabetologia http://link.springer.com/

00:00
Up Front Diabetologia
00:00
Healthful eating patterns, serum metabolite profile and risk of diabetes in a population-based prospective study of US Hispanics/Latinos Diabetologia

Abstract Aims/hypothesis We aimed to evaluate associations of multiple recommended dietary patterns (i.e. the alternate Mediterranean diet [aMED], the Healthy Eating Index [HEI]-2015 and the healthful Plant-based Diet Index [hPDI]) with serum metabolite profile, and to examine (...)
00:00
Unravelling innervation of pancreatic islets Diabetologia

Abstract The central and peripheral nervous systems play critical roles in regulating pancreatic islet function and glucose metabolism. Over the last century, in vitro and in vivo studies along with examination of human pancreas samples have revealed the structure of islet innervation, (...)
00:00
Association of gut microbiota with glycaemic traits and incident type 2 diabetes, and modulation by habitual diet: a population-based longitudinal cohort study in Chinese adults Diabetologia

Abstract Aims/hypothesis The gut microbiome is mainly shaped by diet, and varies across geographical regions. Little is known about the longitudinal association of gut microbiota with glycaemic control. We aimed to identify gut microbiota prospectively associated with glycaemic traits and type (...)

30 June

Diabetologia http://link.springer.com/

00:00
A genome-wide cross-trait analysis identifies shared loci and causal relationships of type 2 diabetes and glycaemic traits with polycystic ovary syndrome Diabetologia

Abstract Aims/hypothesis The link underlying abnormal glucose metabolism, type 2 diabetes and polycystic ovary syndrome (PCOS) that is independent of BMI remains unclear in observational studies. We aimed to clarify this association using a genome-wide cross-trait approach. Methods Summary (...)
00:00
Gut microbiota mediate melatonin signalling in association with type 2 diabetes Diabetologia

Abstract Aims/hypothesis It has been shown that melatonin plays a general beneficial role in type 2 diabetes in rodents but its role in humans is controversial. In the present study, we investigated the association between serum melatonin and type 2 diabetes risk in a southern Chinese (...)

28 June

Diabetologia http://link.springer.com/

00:00
Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease Diabetologia

Abstract Aims/hypothesis Diabetic kidney disease (DKD) is the leading cause of kidney failure and has a substantial genetic component. Our aim was to identify novel genetic factors and genes contributing to DKD by performing meta-analysis of previous genome-wide association studies (GWAS) on (...)
00:00
Clinical variable-based cluster analysis identifies novel subgroups with a distinct genetic signature, lipidomic pattern and cardio-renal risks in Asian patients with recent-onset type 2 diabetes Diabetologia

Abstract Aims/hypothesis We sought to subtype South East Asian patients with type 2 diabetes by de novo cluster analysis on clinical variables, and to determine whether the novel subgroups carry distinct genetic and lipidomic features as well as differential cardio-renal risks. Methods (...)

24 June

Diabetologia http://link.springer.com/

00:00
Continuous glucose monitoring and hypoglycaemia events: unmet needs. Reply to Papaioannou TG, Snoudou D and Tsiofis C [letter] Diabetologia
00:00
A roadmap to achieve pharmacological precision medicine in diabetes Diabetologia

Abstract Current pharmacological treatment of diabetes is largely algorithmic. Other than for cardiovascular disease or renal disease, where sodium–glucose cotransporter 2 inhibitors and/or glucagon-like peptide-1 receptor agonists are indicated, the choice of treatment is based upon overall (...)

23 June

Diabetologia http://link.springer.com/

00:00
Continuous glucose monitoring and hypoglycaemia events: unmet needs Diabetologia

22 June

Diabetologia http://link.springer.com/

00:00
The role of mental disorders in precision medicine for diabetes: a narrative review Diabetologia

Abstract This narrative review aims to examine the value of addressing mental disorders as part of the care of people with type 1 and type 2 diabetes in terms of four components of precision medicine. First, we review the empirical literature on the role of common mental disorders in the (...)

21 June

Diabetologia http://link.springer.com/

00:00
Up Front Diabetologia
00:00
Precision prognostics for the development of complications in diabetes Diabetologia

Abstract Individuals with diabetes face higher risks for macro- and microvascular complications than their non-diabetic counterparts. The concept of precision medicine in diabetes aims to optimise treatment decisions for individual patients to reduce the risk of major diabetic complications, (...)

20 June

Diabetologia http://link.springer.com/

00:00
Correction to: Association of gut microbiota with glycaemic traits and incident type 2 diabetes, and modulation by habitual diet: a population-based longitudinal cohort study in Chinese adults Diabetologia

18 June

Diabetologia http://link.springer.com/

00:00
Umbilical cord blood DNA methylation in children who later develop type 1 diabetes Diabetologia

Abstract Aims/hypothesis Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA methylation is associated with later progression to type 1 diabetes. Methods Reduced (...)

16 June

Diabetologia http://link.springer.com/

00:00
A miR-125/Sirtuin-7 pathway drives the pro-calcific potential of myeloid cells in diabetic vascular disease Diabetologia

Abstract Aims/hypothesis Ectopic calcification is a typical feature of diabetic vascular disease and resembles an accelerated ageing phenotype. We previously found an excess of myeloid calcifying cells in diabetic individuals. We herein examined molecular and cellular pathways linking (...)
00:00
Exploring ethnic representativeness in diabetes clinical trial enrolment from 2000 to 2020: a chronological survey Diabetologia

Abstract Aims/hypothesis Ethnic representativeness of participant enrolment in diabetes RCTs involving multiple ethnicities remains unknown. The aims of this study were to evaluate the status and temporal trend of ethnic representativeness in enrolment to diabetes RCTs, and to assess (...)

15 June

Diabetologia http://link.springer.com/

00:00
Impact of diabetes on COVID-19 prognosis beyond comorbidity burden: the CORONADO initiative Diabetologia

Abstract Aims/hypothesis Diabetes has been recognised as a pejorative prognostic factor in coronavirus disease 2019 (COVID-19). Since diabetes is typically a disease of advanced age, it remains unclear whether diabetes remains a COVID-19 risk factor beyond advanced age and associated (...)

10 June

Diabetologia http://link.springer.com/

00:00
GLP-1 receptor nitration contributes to loss of brain pericyte function in a mouse model of diabetes Diabetologia

Abstract Aims/hypothesis We have previously shown that diabetes causes pericyte dysfunction, leading to loss of vascular integrity and vascular cognitive impairment and dementia (VCID). Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs), used in managing type 2 diabetes mellitus, (...)

5 June

Diabetologia http://link.springer.com/

00:00
Obesity in late adolescence and incident type 1 diabetes in young adulthood Diabetologia

Abstract Aims/hypothesis Studies in children have reported an association between increased BMI and risk for developing type 1 diabetes, but evidence in late adolescence is limited. We studied the association between BMI in late adolescence and incident type 1 diabetes in young adulthood. (...)

2 June

Diabetologia http://link.springer.com/

00:00
Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation Diabetologia

Abstract Aims/hypothesis Type 2 diabetes is characterised by hyperglucagonaemia and perturbed function of pancreatic glucagon-secreting alpha cells but the molecular mechanisms contributing to these phenotypes are poorly understood. Insulin-degrading enzyme (IDE) is present within all islet (...)
00:00
Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation Diabetologia

Abstract Aims/hypothesis Type 2 diabetes is characterised by hyperglucagonaemia and perturbed function of pancreatic glucagon-secreting alpha cells but the molecular mechanisms contributing to these phenotypes are poorly understood. Insulin-degrading enzyme (IDE) is present within all islet (...)

1 June

Diabetologia http://link.springer.com/

00:00
Correction to: Defining the underlying defect in insulin action in type 2 diabetes Diabetologia
00:00
Correction to: The suitability of patient-reported outcome measures used to assess the impact of hypoglycaemia on quality of life in people with diabetes: a systematic review using COSMIN methods Diabetologia
00:00
Long-term outcomes of dietary carbohydrate restriction for HbA1c reduction in type 2 diabetes mellitus are needed Diabetologia
00:00
Long-term outcomes of dietary carbohydrate restriction for HbA1c reduction in type 2 diabetes mellitus are needed. Reply to Kang J and Ma E [letter] Diabetologia
00:00
Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats Diabetologia

Abstract Aim/hypothesis Urocortin-3 (UCN3) is a glucoregulatory peptide produced in the gut and pancreatic islets. The aim of this study was to clarify the acute effects of UCN3 on glucose regulation following an oral glucose challenge and to investigate the mechanisms involved. Methods We (...)
00:00
Mortality trends in type 1 diabetes: a multicountry analysis of six population-based cohorts Diabetologia

Abstract Aims/hypothesis Mortality has declined in people with type 1 diabetes in recent decades. We examined how the pattern of decline differs by country, age and sex, and how mortality trends in type 1 diabetes relate to trends in general population mortality. Methods We assembled (...)
00:00
XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice Diabetologia

Abstract Aims/hypothesis Pancreatic beta cell dedifferentiation, transdifferentiation into other islet cells and apoptosis have been implicated in beta cell failure in type 2 diabetes, although the mechanisms are poorly defined. The endoplasmic reticulum stress response factor X-box binding (...)
00:00
Characteristics of adults with type 1 diabetes and treatment-resistant problematic hypoglycaemia: a baseline analysis from the HARPdoc RCT Diabetologia

Abstract Aims/hypothesis Problematic hypoglycaemia still complicates insulin therapy for some with type 1 diabetes. This study describes baseline emotional, cognitive and behavioural characteristics in participants in the HARPdoc trial, which evaluates a novel intervention for (...)
00:00
Maturation of beta cells: lessons from in vivo and in vitro models Diabetologia

Abstract The ability to maintain normoglycaemia, through glucose-sensitive insulin release, is a key aspect of postnatal beta cell function. However, terminally differentiated beta cell identity does not necessarily imply functional maturity. Beta cell maturation is therefore a continuation of (...)
00:00
Mucosal-associated invariant T cells are associated with insulin resistance in childhood obesity, and disrupt insulin signalling via IL-17 Diabetologia

Abstract Aims/hypothesis Mucosal-associated invariant T cells (MAIT cells) are an abundant population of innate T cells. When activated, MAIT cells rapidly produce a range of cytokines, including IFN?, TNF-? and IL-17. Several studies have implicated MAIT cells in the development of metabolic (...)
00:00
Long-term outcomes of dietary carbohydrate restriction for HbA1c reduction in type 2 diabetes mellitus are needed Diabetologia

24 May

Diabetologia http://link.springer.com/

00:00
Risk of incident obstructive sleep apnoea in patients with type 1 diabetes: a population-based retrospective cohort study Diabetologia

Abstract Aims/hypothesis People with type 2 diabetes are at increased risk of developing obstructive sleep apnoea. However, it is not known whether people with type 1 diabetes are also at an increased risk of obstructive sleep apnoea. This study aimed to examine whether people with type 1 (...)

20 May

Diabetologia http://link.springer.com/

00:00
Precision nutrition in diabetes: when population-based dietary advice gets personal Diabetologia

Abstract Diet plays a fundamental role in maintaining long-term health, with healthful diets being endorsed by current dietary guidelines for the prevention and management of type 2 diabetes. However, the response to dietary interventions varies widely, highlighting the need for refinement and (...)

19 May

Diabetologia http://link.springer.com/

00:00
Low- and middle-income countries demonstrate rapid growth of type 2 diabetes: an analysis based on Global Burden of Disease 1990–2019 data Diabetologia

Abstract Aims/hypothesis The study aims to quantify the global trend of the disease burden of type 2 diabetes caused by various risks factors by country income tiers. Methods Data on type 2 diabetes, including mortality and disability-adjusted life years (DALYs) during 1990–2019, were obtained (...)

17 May

Diabetologia http://link.springer.com/

00:00
Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: a systematic review and meta-analysis Diabetologia

Abstract Aims/hypothesis Tirzepatide is a novel dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) currently under review for marketing approval. Individual trials have assessed the clinical profile of tirzepatide vs different (...)
00:00
Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: a systematic review and meta-analysis Diabetologia

Abstract Aims/hypothesis Tirzepatide is a novel dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) currently under review for marketing approval. Individual trials have assessed the clinical profile of tirzepatide vs different (...)

12 May

Diabetologia http://link.springer.com/

00:00
Addition of intermittently scanned continuous glucose monitoring to standard care in a cohort of pregnant women with type 1 diabetes: effect on glycaemic control and pregnancy outcomes Diabetologia

Abstract Aims/hypothesis The aim of this study was to assess whether the addition of intermittently scanned continuous glucose monitoring (isCGM) to standard care (self-monitoring of blood glucose [SMBG] alone) improves glycaemic control and pregnancy outcomes in women with type 1 diabetes and (...)

11 May

Diabetologia http://link.springer.com/

00:00
Health impact of seven herpesviruses on (pre)diabetes incidence and HbA1c: results from the KORA cohort Diabetologia

Abstract Aims/hypothesis The prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are seropositive for herpesviruses. This study examines the prospective association of herpesviruses with (pre)diabetes to evaluate their (...)

5 May

Diabetologia http://link.springer.com/

00:00
Human adipose-derived mesenchymal stem cells prevent type 1 diabetes induced by immune checkpoint blockade Diabetologia

Abstract Aims/hypothesis Immunomodulators blocking cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) or programmed death-ligand 1 (PD-L1) have improved the treatment of a broad spectrum of cancers. These immune checkpoint inhibitors (ICIs) (...)
00:00
Human adipose-derived mesenchymal stem cells prevent type 1 diabetes induced by immune checkpoint blockade Diabetologia

Abstract Aims/hypothesis Immunomodulators blocking cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) or programmed death-ligand 1 (PD-L1) have improved the treatment of a broad spectrum of cancers. These immune checkpoint inhibitors (ICIs) (...)

4 May

Diabetologia http://link.springer.com/

00:00
Insulin allergy: a diagnostic and therapeutic strategy based on a retrospective cohort and a case–control study Diabetologia

Abstract Aims/hypothesis Insulin allergy is a rare but significant clinical challenge. We aimed to develop a management workflow by (1) validating clinical criteria to guide diagnosis, based on a retrospective cohort, and (2) assessing the diagnostic performance of confirmatory tests, based on (...)

1 May

Diabetologia http://link.springer.com/

00:00
Correction to: A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY Diabetologia
00:00
Ertugliflozin, renoprotection and potential confounding by muscle wasting Diabetologia
00:00
Urinary albumin/creatinine ratio tertiles predict risk of diabetic retinopathy progression: a natural history study from the Adolescent Cardio-Renal Intervention Trial (AdDIT) observational cohort Diabetologia

Abstract Aims/hypothesis We hypothesised that adolescents with type 1 diabetes with a urinary albumin/creatinine ratio (ACR) in the upper tertile of the normal range (high ACR) are at greater risk of three-step diabetic retinopathy progression (3DR) independent of glycaemic control. Methods (...)
00:00
Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts Diabetologia

Abstract Aims/hypothesis Type 2 diabetes is a complex metabolic disease with increasing prevalence worldwide. Improving the prediction of incident type 2 diabetes using epigenetic markers could help tailor prevention efforts to those at the highest risk. The aim of this study was to identify (...)
00:00
Ertugliflozin, renoprotection and potential confounding by muscle wasting. Reply to Groothof D, Post A, Gans ROB et al [letter] Diabetologia
00:00
Early DNA methylation changes in children developing beta cell autoimmunity at a young age Diabetologia

Abstract Aims/hypothesis Type 1 diabetes is a chronic autoimmune disease of complex aetiology, including a potential role for epigenetic regulation. Previous epigenomic studies focused mainly on clinically diagnosed individuals. The aim of the study was to assess early DNA methylation changes (...)
00:00
Spatial and transcriptional heterogeneity of pancreatic beta cell neogenesis revealed by a time-resolved reporter system Diabetologia

Abstract Aims/hypothesis While pancreatic beta cells have been shown to originate from endocrine progenitors in ductal regions, it remains unclear precisely where beta cells emerge from and which transcripts define newborn beta cells. We therefore investigated characteristics of newborn beta (...)
00:00
Prediabetes blunts DPP4 genetic control of postprandial glycaemia and insulin secretion Diabetologia

Abstract Aims/hypothesis Imbalances in glucose metabolism are hallmarks of clinically silent prediabetes (defined as impaired fasting glucose and/or impaired glucose tolerance) representing dysmetabolism trajectories leading to type 2 diabetes. CD26/dipeptidyl peptidase 4 (DPP4) is a (...)
00:00
Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice Diabetologia

Abstract Aims/hypothesis Diabetic cardiomyopathy (DCM) is a serious and under-recognised complication of diabetes. The first sign is diastolic dysfunction, which progresses to heart failure. The pathophysiology of DCM is incompletely understood but microcirculatory changes are important. (...)
00:00
Familial aggregation and shared genetic loading for major psychiatric disorders and type 2 diabetes Diabetologia

Abstract Aims/hypothesis Psychiatric disorders, such as schizophrenia (SCZ), major depressive disorder (MDD) and bipolar disorder (BPD), are highly comorbid with type 2 diabetes. However, the mechanisms underlying such comorbidity are understudied. This study explored the familial aggregation (...)
00:00
Ertugliflozin, renoprotection and potential confounding by muscle wasting Diabetologia

30 April

Diabetologia http://link.springer.com/

00:00
Genetic risk of type 2 diabetes modifies the effects of a lifestyle intervention aimed at the prevention of gestational and postpartum diabetes Diabetologia

Abstract Aims/hypothesis The aim of this study was to assess the interaction between genetic risk and lifestyle intervention on the occurrence of gestational diabetes mellitus (GDM) and postpartum diabetes. Methods The RADIEL study is an RCT aimed at prevention of GDM and postpartum diabetes (...)
00:00
Congenital beta cell defects are not associated with markers of islet autoimmunity, even in the context of high genetic risk for type 1 diabetes Diabetologia

Abstract Aims/hypothesis A key unanswered question in type 1 diabetes is whether beta cells initiate their own destruction or are victims of an aberrant immune response (beta cell suicide or homicide?). To investigate this, we assessed islet autoantibodies in individuals with congenital beta (...)
00:00
Early vs late histological confirmation of coeliac disease in children with new-onset type 1 diabetes Diabetologia

Abstract Aim Screening for coeliac disease in asymptomatic children with new-onset type 1 diabetes is controversial. The aim of this study was to analyse whether the confirmation of coeliac disease in children with new-onset type 1 diabetes and positive screening results can be postponed. (...)
00:00
Paternal eNOS deficiency in mice affects glucose homeostasis and liver glycogen in male offspring without inheritance of eNOS deficiency itself Diabetologia

Abstract Aims/hypothesis It was shown that maternal endothelial nitric oxide synthase (eNOS) deficiency causes fatty liver disease and numerically lower fasting glucose in female wild-type offspring, suggesting that parental genetic variants may influence the offspring’s phenotype via (...)

28 April

Diabetologia http://link.springer.com/

00:00
Mediators of the association between educational attainment and type 2 diabetes mellitus: a two-step multivariable Mendelian randomisation study Diabetologia

Abstract Aims/hypothesis Type 2 diabetes mellitus is a major health burden disproportionately affecting those with lower educational attainment (EA). We aimed to obtain causal estimates of the association between EA and type 2 diabetes and to quantify mediating effects of known modifiable risk (...)
00:00
Lessons from single-cell RNA sequencing of human islets Diabetologia

Abstract Islet dysfunction is central in type 2 diabetes and full-blown type 2 diabetes develops first when the beta cells lose their ability to secrete adequate amounts of insulin in response to raised plasma glucose. Several mechanisms behind beta cell dysfunction have been put forward but (...)

27 April

Diabetologia http://link.springer.com/

00:00
The 26RFa (QRFP)/GPR103 neuropeptidergic system in mice relays insulin signalling into the brain to regulate glucose homeostasis Diabetologia

Abstract Aims/hypothesis 26RFa (pyroglutamilated RFamide peptide [QRFP]) is a biologically active peptide that regulates glucose homeostasis by acting as an incretin and by increasing insulin sensitivity at the periphery. 26RFa is also produced by a neuronal population localised in the (...)

26 April

Diabetologia http://link.springer.com/

00:00
Correction to: Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function Diabetologia

21 April

Diabetologia http://link.springer.com/

00:00
Effect of dapagliflozin on kidney and cardiovascular outcomes by baseline KDIGO risk categories: a post hoc analysis of the DAPA-CKD trial Diabetologia

Abstract Aims/hypothesis In the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) trial, dapagliflozin reduced the risks of progressive kidney disease, hospitalised heart failure or cardiovascular death, and death from all causes in patients with chronic (...)
00:00
Sleep deprivation prevents counterregulatory adaptation to recurrent hypoglycaemia Diabetologia

Abstract Aims/hypothesis Attenuated counterregulation after recurrent hypoglycaemia is a major complication of diabetes treatment. As there is previous evidence for the relevance of sleep in metabolic control, we assessed the acute contribution of sleep to the counterregulatory adaptation to (...)

14 April

Diabetologia http://link.springer.com/

00:00
Up Front Diabetologia
00:00
Up Front Diabetologia

12 April

Diabetologia http://link.springer.com/

00:00
Where to for precision treatment of HNF1A-MODY? Diabetologia
00:00
Incident cardiovascular disease by clustering of favourable risk factors in type 1 diabetes: the EURODIAB Prospective Complications Study Diabetologia

Abstract Aims The aim of this prospective study was to examine CVD risk reduction in type 1 diabetes (1) for people with favourable cardiovascular health metrics and (2) by clustering of these metrics. Methods Data from 2313 participants from the EURODIAB Prospective Complications Study were (...)
00:00
Where to for precision treatment of HNF1A-MODY? Diabetologia
00:00
Incident cardiovascular disease by clustering of favourable risk factors in type 1 diabetes: the EURODIAB Prospective Complications Study Diabetologia

Abstract Aims The aim of this prospective study was to examine CVD risk reduction in type 1 diabetes (1) for people with favourable cardiovascular health metrics and (2) by clustering of these metrics. Methods Data from 2313 participants from the EURODIAB Prospective Complications Study were (...)

11 April

Diabetologia http://link.springer.com/

00:00
Per- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN) Diabetologia

Abstract Aims/hypothesis Diabetogenic effects of per- and polyfluoroalkyl substances (PFAS) have been suggested. However, evidence based on prospective cohort studies is limited. We examined the association between serum PFAS concentrations and incident diabetes in the Study of Women’s Health (...)
00:00
Per- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN) Diabetologia

Abstract Aims/hypothesis Diabetogenic effects of per- and polyfluoroalkyl substances (PFAS) have been suggested. However, evidence based on prospective cohort studies is limited. We examined the association between serum PFAS concentrations and incident diabetes in the Study of Women’s Health (...)

8 April

Diabetologia http://link.springer.com/

00:00
Plasma metabolite profiles related to plant-based diets and the risk of type 2 diabetes Diabetologia

Abstract Aims/hypothesis Plant-based diets, especially when rich in healthy plant foods, have been associated with a lower risk of type 2 diabetes. However, whether plasma metabolite profiles related to plant-based diets reflect this association was unknown. The aim of this study was to (...)

5 April

Diabetologia http://link.springer.com/

00:00
Coordination of glucose monitoring, self-care behaviour and mental health: achieving precision monitoring in diabetes Diabetologia

Abstract Monitoring of glucose plays an essential role in the management of diabetes. However, to fully understand and meaningfully interpret glucose levels, additional information on context is necessary. Important contextual factors include data on behaviours such as eating, exercise, (...)
00:00
Elevated cerebrospinal fluid glucose levels and diabetes mellitus are associated with activation of the neurotoxic polyol pathway Diabetologia

Abstract Aims/hypothesis During hyperglycaemia, some glucose bypasses glycolysis and is metabolised via the potentially neurotoxic polyol pathway, in which glucose is metabolised to sorbitol and fructose. Increased polyol concentrations have been demonstrated in the cerebrospinal fluid (CSF) (...)

1 April

Diabetologia http://link.springer.com/

00:00
Long-term outcomes of dietary carbohydrate restriction for HbA1c reduction in type 2 diabetes mellitus are needed. Reply to Kang J and Ma E [letter] Diabetologia
00:00
Up front Diabetologia
00:00
Understanding the pathogenesis of lean non-autoimmune diabetes in an African population with newly diagnosed diabetes Diabetologia

Abstract Aims/hypothesis Apparent type 2 diabetes is increasingly reported in lean adult individuals in sub-Saharan Africa. However, studies undertaking robust clinical and metabolic characterisation of lean individuals with new-onset type 2 diabetes are limited in this population. This (...)
00:00
Lipids, hyperreflective crystalline deposits and diabetic retinopathy: potential systemic and retinal-specific effect of lipid-lowering therapies Diabetologia

Abstract The metabolically active retina obtains essential lipids by endogenous biosynthesis and from the systemic circulation. Clinical studies provide limited and sometimes conflicting evidence as to the relationships between circulating lipid levels and the development and progression of (...)
00:00
Using genetics to assess the association of commonly used antihypertensive drugs with diabetes, glycaemic traits and lipids: a trans-ancestry Mendelian randomisation study Diabetologia

Abstract Aims/hypothesis Diabetes and hyperlipidaemia are common comorbidities in people with hypertension. Despite similar protective effects on CVD, different classes of antihypertensive drugs have different effects on CVD risk factors, including diabetes, glucose metabolism and lipids. (...)
00:00
Effectiveness of continuous glucose monitoring in maintaining glycaemic control among people with type 1 diabetes mellitus: a systematic review of randomised controlled trials and meta-analysis Diabetologia

Abstract Aims/hypothesis The aim of this work was to assess the effectiveness of continuous glucose monitoring (CGM) vs self-monitoring of blood glucose (SMBG) in maintaining glycaemic control among people with type 1 diabetes mellitus. Methods Cochrane Library, PubMed, Embase, CINAHL, (...)
00:00
A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY Diabetologia

Abstract Aims/hypothesis Systematic studies on the phenotypic consequences of variants causal of HNF1A-MODY are rare. Our aim was to assess the phenotype of carriers of a single HNF1A variant and genetic and clinical factors affecting the clinical spectrum. Methods We conducted a family-based (...)
00:00
Adiponectin deficiency induces hepatic steatosis during pregnancy and gestational diabetes in mice Diabetologia

Abstract Aims/hypothesis Obesity and hepatic steatosis are risk factors for gestational diabetes mellitus (GDM), a common complication of pregnancy. Adiponectin is a fat-derived hormone that improves hepatic steatosis and insulin sensitivity. Low levels of circulating adiponectin are (...)
00:00
A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY Diabetologia

Abstract Aims/hypothesis Systematic studies on the phenotypic consequences of variants causal of HNF1A-MODY are rare. Our aim was to assess the phenotype of carriers of a single HNF1A variant and genetic and clinical factors affecting the clinical spectrum. Methods We conducted a family-based (...)

24 March

Diabetologia http://link.springer.com/

00:00
Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats Diabetologia

Abstract Aim/hypothesis Urocortin-3 (UCN3) is a glucoregulatory peptide produced in the gut and pancreatic islets. The aim of this study was to clarify the acute effects of UCN3 on glucose regulation following an oral glucose challenge and to investigate the mechanisms involved. Methods We (...)
00:00
Characteristics of adults with type 1 diabetes and treatment-resistant problematic hypoglycaemia: a baseline analysis from the HARPdoc RCT Diabetologia

Abstract Aims/hypothesis Problematic hypoglycaemia still complicates insulin therapy for some with type 1 diabetes. This study describes baseline emotional, cognitive and behavioural characteristics in participants in the HARPdoc trial, which evaluates a novel intervention for (...)

23 March

Diabetologia http://link.springer.com/

22 March

Diabetologia http://link.springer.com/

00:00
Mortality trends in type 1 diabetes: a multicountry analysis of six population-based cohorts Diabetologia

Abstract Aims/hypothesis Mortality has declined in people with type 1 diabetes in recent decades. We examined how the pattern of decline differs by country, age and sex, and how mortality trends in type 1 diabetes relate to trends in general population mortality. Methods We assembled (...)
00:00
XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice Diabetologia

Abstract Aims/hypothesis Pancreatic beta cell dedifferentiation, transdifferentiation into other islet cells and apoptosis have been implicated in beta cell failure in type 2 diabetes, although the mechanisms are poorly defined. The endoplasmic reticulum stress response factor X-box binding (...)

21 March

Diabetologia http://link.springer.com/

00:00
Pharmacoepigenetics in type 2 diabetes: is it clinically relevant? Diabetologia

Abstract Data generated over nearly two decades clearly demonstrate the importance of epigenetic modifications and mechanisms in the pathogenesis of type 2 diabetes. However, the role of pharmacoepigenetics in type 2 diabetes is less well established. The field of pharmacoepigenetics covers (...)

19 March

Diabetologia http://link.springer.com/

00:00
Mucosal-associated invariant T cells are associated with insulin resistance in childhood obesity, and disrupt insulin signalling via IL-17 Diabetologia

Abstract Aims/hypothesis Mucosal-associated invariant T cells (MAIT cells) are an abundant population of innate T cells. When activated, MAIT cells rapidly produce a range of cytokines, including IFN?, TNF-? and IL-17. Several studies have implicated MAIT cells in the development of metabolic (...)

16 March

Diabetologia http://link.springer.com/

00:00
The COVID-19 pandemic may be receding but the diabetes pandemic rages on Diabetologia
00:00
Up Front Diabetologia
00:00
Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase Diabetologia

Abstract Aims/hypothesis Although targeted in extrapancreatic tissues by several drugs used to treat type 2 diabetes, the role of AMP-activated protein kinase (AMPK) in the control of insulin secretion is still debatable. Previous studies have used pharmacological activators of limited (...)
00:00
Incidence of newly diagnosed diabetes after Covid-19 Diabetologia

Abstract Aims/hypothesis The aim of this work was to investigate diabetes incidence after infection with coronavirus disease-2019 (Covid-19). Individuals with acute upper respiratory tract infections (AURI), which are frequently caused by viruses, were selected as a non-exposed control group. (...)
00:00
The COVID-19 pandemic may be receding but the diabetes pandemic rages on Diabetologia
00:00
Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase Diabetologia

Abstract Aims/hypothesis Although targeted in extrapancreatic tissues by several drugs used to treat type 2 diabetes, the role of AMP-activated protein kinase (AMPK) in the control of insulin secretion is still debatable. Previous studies have used pharmacological activators of limited (...)
00:00
Up Front Diabetologia
00:00
Incidence of newly diagnosed diabetes after Covid-19 Diabetologia

Abstract Aims/hypothesis The aim of this work was to investigate diabetes incidence after infection with coronavirus disease-2019 (Covid-19). Individuals with acute upper respiratory tract infections (AURI), which are frequently caused by viruses, were selected as a non-exposed control group. (...)

15 March

Diabetologia http://link.springer.com/

00:00
Loss of function of renal Glut2 reverses hyperglycaemia and normalises body weight in mouse models of diabetes and obesity Diabetologia

Abstract Aims/hypothesis Renal GLUT2 is increased in diabetes, thereby enhancing glucose reabsorption and worsening hyperglycaemia. Here, we determined whether loss of Glut2 (also known as Slc2a2) specifically in the kidneys would reverse hyperglycaemia and normalise body weight in mouse (...)
00:00
Loss of function of renal Glut2 reverses hyperglycaemia and normalises body weight in mouse models of diabetes and obesity Diabetologia

Abstract Aims/hypothesis Renal GLUT2 is increased in diabetes, thereby enhancing glucose reabsorption and worsening hyperglycaemia. Here, we determined whether loss of Glut2 (also known as Slc2a2) specifically in the kidneys would reverse hyperglycaemia and normalise body weight in mouse (...)

11 March

Diabetologia http://link.springer.com/

00:00
Diabetes, GDF-15 and incident heart failure: the atherosclerosis risk in communities study Diabetologia

Abstract Aims/hypothesis Elevated circulating growth differentiation factor-15 (GDF-15), a marker of cellular stress, is associated with both heart failure (HF) and diabetes. However, it is unclear to what extent GDF-15 is associated with HF among individuals with and without diabetes. Methods (...)
00:00
The insulin market reaches 100 Diabetologia
00:00
High-intensity interval training for 12 weeks improves cardiovascular autonomic function but not somatosensory nerve function and structure in overweight men with type 2 diabetes Diabetologia

Abstract Aims/hypothesis It remains unclear whether and which modality of exercise training as a component of lifestyle intervention may exert favourable effects on somatosensory and autonomic nerve tests in people with type 2 diabetes. Methods Cardiovascular autonomic and somatosensory nerve (...)
00:00
Diabetes, GDF-15 and incident heart failure: the atherosclerosis risk in communities study Diabetologia

Abstract Aims/hypothesis Elevated circulating growth differentiation factor-15 (GDF-15), a marker of cellular stress, is associated with both heart failure (HF) and diabetes. However, it is unclear to what extent GDF-15 is associated with HF among individuals with and without diabetes. Methods (...)
00:00
The insulin market reaches 100 Diabetologia
00:00
High-intensity interval training for 12 weeks improves cardiovascular autonomic function but not somatosensory nerve function and structure in overweight men with type 2 diabetes Diabetologia

Abstract Aims/hypothesis It remains unclear whether and which modality of exercise training as a component of lifestyle intervention may exert favourable effects on somatosensory and autonomic nerve tests in people with type 2 diabetes. Methods Cardiovascular autonomic and somatosensory nerve (...)

9 March

Diabetologia http://link.springer.com/

00:00
Referees 2021 Diabetologia
00:00
Referees 2021 Diabetologia

5 March

Diabetologia http://link.springer.com/

00:00
Reversibility of brain glucose kinetics in type 2 diabetes mellitus Diabetologia

Abstract Aims/hypothesis We have previously shown that individuals with uncontrolled type 2 diabetes have a blunted rise in brain glucose levels measured by 1H magnetic resonance spectroscopy. Here, we investigate whether reductions in HbA1c normalise intracerebral glucose levels. Methods (...)
00:00
Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function Diabetologia

Abstract Aims/hypothesis South Asians in general, and Asian Indians in particular, have higher risk of type 2 diabetes compared with white Europeans, and a younger age of onset. The reasons for the younger age of onset in relation to obesity, beta cell function and insulin sensitivity are (...)
00:00
Reversibility of brain glucose kinetics in type 2 diabetes mellitus Diabetologia

Abstract Aims/hypothesis We have previously shown that individuals with uncontrolled type 2 diabetes have a blunted rise in brain glucose levels measured by 1H magnetic resonance spectroscopy. Here, we investigate whether reductions in HbA1c normalise intracerebral glucose levels. Methods (...)
00:00
Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function Diabetologia

Abstract Aims/hypothesis South Asians in general, and Asian Indians in particular, have higher risk of type 2 diabetes compared with white Europeans, and a younger age of onset. The reasons for the younger age of onset in relation to obesity, beta cell function and insulin sensitivity are (...)

4 March

Diabetologia http://link.springer.com/

00:00
When therapeutic drugs lead to diabetes Diabetologia

Abstract Drug-induced diabetes mellitus is a growing problem in clinical practice. New, potent medications contribute to this problem in a population already at high risk of developing glucose disturbances because of poor lifestyle habits and high prevalence of being overweight/obese. The (...)
00:00
When therapeutic drugs lead to diabetes Diabetologia

Abstract Drug-induced diabetes mellitus is a growing problem in clinical practice. New, potent medications contribute to this problem in a population already at high risk of developing glucose disturbances because of poor lifestyle habits and high prevalence of being overweight/obese. The (...)
00:00
Maturation of beta cells: lessons from in vivo and in vitro models Diabetologia

Abstract The ability to maintain normoglycaemia, through glucose-sensitive insulin release, is a key aspect of postnatal beta cell function. However, terminally differentiated beta cell identity does not necessarily imply functional maturity. Beta cell maturation is therefore a continuation of (...)

3 March

Diabetologia http://link.springer.com/

00:00
Spatial and transcriptional heterogeneity of pancreatic beta cell neogenesis revealed by a time-resolved reporter system Diabetologia

Abstract Aims/hypothesis While pancreatic beta cells have been shown to originate from endocrine progenitors in ductal regions, it remains unclear precisely where beta cells emerge from and which transcripts define newborn beta cells. We therefore investigated characteristics of newborn beta (...)
00:00
Correction to: A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY Diabetologia
00:00
Ertugliflozin, renoprotection and potential confounding by muscle wasting. Reply to Groothof D, Post A, Gans ROB et al [letter] Diabetologia

1 March

Diabetologia http://link.springer.com/

00:00
The insulin hypersecretion hypothesis: cause or effect? Reply to Polychronakos C [letter] Diabetologia
00:00
The insulin hypersecretion hypothesis: cause or effect? Diabetologia
00:00
Up Front Diabetologia
00:00
Prevalence of type 2 diabetes in psychiatric disorders: an umbrella review with meta-analysis of 245 observational studies from 32 systematic reviews Diabetologia

Abstract Aims/hypothesis Estimates of the global prevalence of type 2 diabetes vary between 6% and 9%. The prevalence of type 2 diabetes has been investigated in psychiatric populations but a critical appraisal of the existing evidence is lacking, and an overview is needed. This umbrella (...)
00:00
The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice Diabetologia

Abstract Aims/hypothesis Second-generation antipsychotic (SGA) drugs have been associated with the development of type 2 diabetes and the metabolic syndrome in patients with schizophrenia. In this study, we aimed to investigate the effects of two different SGA drugs, olanzapine and (...)
00:00
MicroRNA-193b impairs muscle growth in mouse models of type 2 diabetes by targeting the PDK1/Akt signalling pathway Diabetologia

Abstract Aims/hypothesis Type 2 diabetes is associated with a reduction in skeletal muscle mass; however, how the progression of sarcopenia is induced and regulated remains largely unknown. We aimed to find out whether a specific microRNA (miR) may contribute to skeletal muscle atrophy in type (...)
00:00
Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet Diabetologia

Abstract Aims/hypothesis Despite a similar fat storing function, visceral (intra-abdominal) white adipose tissue (WAT) is detrimental, whereas subcutaneous WAT is considered to protect against metabolic disease. Recent findings indicate that thermogenic genes, expressed in brown adipose tissue (...)
00:00
Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study Diabetologia

Abstract Aims/hypothesis Type 2 diabetes is a growing global public health challenge. Investigating quantitative traits, including fasting glucose, fasting insulin and HbA1c, that serve as early markers of type 2 diabetes progression may lead to a deeper understanding of the genetic aetiology (...)
00:00
Differences in the prevalence of erectile dysfunction between novel subgroups of recent-onset diabetes Diabetologia

Abstract Aims/hypothesis In men with diabetes, the prevalence of erectile dysfunction increases with advanced age and longer diabetes duration and is substantially higher in men with type 2 diabetes than those with type 1 diabetes. This study aimed to evaluate the prevalence of erectile (...)
00:00
Artificial intelligence utilising corneal confocal microscopy for the diagnosis of peripheral neuropathy in diabetes mellitus and prediabetes Diabetologia

Abstract Aims/hypothesis We aimed to develop an artificial intelligence (AI)-based deep learning algorithm (DLA) applying attribution methods without image segmentation to corneal confocal microscopy images and to accurately classify peripheral neuropathy (or lack of). Methods The AI-based (...)
00:00
Longitudinal changes in glucose during pregnancy in women with gestational diabetes risk factors Diabetologia

Abstract Aims/hypothesis Despite recommendations to screen women with diabetes risk factors for hyperglycaemia in the first trimester, criteria for normal glucose values in early pregnancy have not been firmly established. We aimed to compare glucose levels in early pregnancy with those later (...)
00:00
Higher baseline inflammatory marker levels predict greater cognitive decline in older people with type 2 diabetes: year 10 follow-up of the Edinburgh Type 2 Diabetes Study Diabetologia

Abstract Aims/hypothesis We aimed to determine the longitudinal association of circulating markers of systemic inflammation with subsequent long-term cognitive change in older people with type 2 diabetes. Methods The Edinburgh Type 2 Diabetes Study is a prospective cohort study of 1066 adults (...)
00:00
Advanced liver fibrosis measured by transient elastography predicts chronic kidney disease development in individuals with non-alcoholic fatty liver disease Diabetologia

Abstract Aims/hypothesis Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are progressive chronic conditions that share important cardiometabolic risk factors and pathogenic mechanisms. We investigated the association between liver fibrosis measured by transient (...)
00:00
The insulin hypersecretion hypothesis: cause or effect? Reply to Polychronakos C [letter] Diabetologia
00:00
The insulin hypersecretion hypothesis: cause or effect? Diabetologia
00:00
Prevalence of type 2 diabetes in psychiatric disorders: an umbrella review with meta-analysis of 245 observational studies from 32 systematic reviews Diabetologia

Abstract Aims/hypothesis Estimates of the global prevalence of type 2 diabetes vary between 6% and 9%. The prevalence of type 2 diabetes has been investigated in psychiatric populations but a critical appraisal of the existing evidence is lacking, and an overview is needed. This umbrella (...)
00:00
The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice Diabetologia

Abstract Aims/hypothesis Second-generation antipsychotic (SGA) drugs have been associated with the development of type 2 diabetes and the metabolic syndrome in patients with schizophrenia. In this study, we aimed to investigate the effects of two different SGA drugs, olanzapine and (...)
00:00
MicroRNA-193b impairs muscle growth in mouse models of type 2 diabetes by targeting the PDK1/Akt signalling pathway Diabetologia

Abstract Aims/hypothesis Type 2 diabetes is associated with a reduction in skeletal muscle mass; however, how the progression of sarcopenia is induced and regulated remains largely unknown. We aimed to find out whether a specific microRNA (miR) may contribute to skeletal muscle atrophy in type (...)
00:00
Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet Diabetologia

Abstract Aims/hypothesis Despite a similar fat storing function, visceral (intra-abdominal) white adipose tissue (WAT) is detrimental, whereas subcutaneous WAT is considered to protect against metabolic disease. Recent findings indicate that thermogenic genes, expressed in brown adipose tissue (...)
00:00
Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study Diabetologia

Abstract Aims/hypothesis Type 2 diabetes is a growing global public health challenge. Investigating quantitative traits, including fasting glucose, fasting insulin and HbA1c, that serve as early markers of type 2 diabetes progression may lead to a deeper understanding of the genetic aetiology (...)
00:00
Differences in the prevalence of erectile dysfunction between novel subgroups of recent-onset diabetes Diabetologia

Abstract Aims/hypothesis In men with diabetes, the prevalence of erectile dysfunction increases with advanced age and longer diabetes duration and is substantially higher in men with type 2 diabetes than those with type 1 diabetes. This study aimed to evaluate the prevalence of erectile (...)
00:00
Artificial intelligence utilising corneal confocal microscopy for the diagnosis of peripheral neuropathy in diabetes mellitus and prediabetes Diabetologia

Abstract Aims/hypothesis We aimed to develop an artificial intelligence (AI)-based deep learning algorithm (DLA) applying attribution methods without image segmentation to corneal confocal microscopy images and to accurately classify peripheral neuropathy (or lack of). Methods The AI-based (...)
00:00
Longitudinal changes in glucose during pregnancy in women with gestational diabetes risk factors Diabetologia

Abstract Aims/hypothesis Despite recommendations to screen women with diabetes risk factors for hyperglycaemia in the first trimester, criteria for normal glucose values in early pregnancy have not been firmly established. We aimed to compare glucose levels in early pregnancy with those later (...)
00:00
Higher baseline inflammatory marker levels predict greater cognitive decline in older people with type 2 diabetes: year 10 follow-up of the Edinburgh Type 2 Diabetes Study Diabetologia

Abstract Aims/hypothesis We aimed to determine the longitudinal association of circulating markers of systemic inflammation with subsequent long-term cognitive change in older people with type 2 diabetes. Methods The Edinburgh Type 2 Diabetes Study is a prospective cohort study of 1066 adults (...)
00:00
Advanced liver fibrosis measured by transient elastography predicts chronic kidney disease development in individuals with non-alcoholic fatty liver disease Diabetologia

Abstract Aims/hypothesis Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are progressive chronic conditions that share important cardiometabolic risk factors and pathogenic mechanisms. We investigated the association between liver fibrosis measured by transient (...)

25 February

Diabetologia http://link.springer.com/

00:00
Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice Diabetologia

Abstract Aims/hypothesis Diabetic cardiomyopathy (DCM) is a serious and under-recognised complication of diabetes. The first sign is diastolic dysfunction, which progresses to heart failure. The pathophysiology of DCM is incompletely understood but microcirculatory changes are important. (...)

23 February

Diabetologia http://link.springer.com/

00:00
Familial aggregation and shared genetic loading for major psychiatric disorders and type 2 diabetes Diabetologia

Abstract Aims/hypothesis Psychiatric disorders, such as schizophrenia (SCZ), major depressive disorder (MDD) and bipolar disorder (BPD), are highly comorbid with type 2 diabetes. However, the mechanisms underlying such comorbidity are understudied. This study explored the familial aggregation (...)

22 February

Diabetologia http://link.springer.com/

00:00
Prediabetes blunts DPP4 genetic control of postprandial glycaemia and insulin secretion Diabetologia

Abstract Aims/hypothesis Imbalances in glucose metabolism are hallmarks of clinically silent prediabetes (defined as impaired fasting glucose and/or impaired glucose tolerance) representing dysmetabolism trajectories leading to type 2 diabetes. CD26/dipeptidyl peptidase 4 (DPP4) is a (...)

19 February

Diabetologia http://link.springer.com/

00:00
Up front Diabetologia
00:00
Urinary albumin/creatinine ratio tertiles predict risk of diabetic retinopathy progression: a natural history study from the Adolescent Cardio-Renal Intervention Trial (AdDIT) observational cohort Diabetologia

Abstract Aims/hypothesis We hypothesised that adolescents with type 1 diabetes with a urinary albumin/creatinine ratio (ACR) in the upper tertile of the normal range (high ACR) are at greater risk of three-step diabetic retinopathy progression (3DR) independent of glycaemic control. Methods (...)

15 February

Diabetologia http://link.springer.com/

00:00
Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts Diabetologia

Abstract Aims/hypothesis Type 2 diabetes is a complex metabolic disease with increasing prevalence worldwide. Improving the prediction of incident type 2 diabetes using epigenetic markers could help tailor prevention efforts to those at the highest risk. The aim of this study was to identify (...)

12 February

Diabetologia http://link.springer.com/

00:00
Lifestyle interventions in pregnancy targeting GDM prevention: looking ahead to precision medicine Diabetologia

Abstract Gestational diabetes mellitus (GDM) is the most prevalent pregnancy-related endocrinopathy, affecting up to 25% of pregnancies worldwide. Pregnant individuals who develop GDM have an increased risk of complications during pregnancy and birth, as well as future development of type 2 (...)

11 February

Diabetologia http://link.springer.com/

00:00
Lipids, hyperreflective crystalline deposits and diabetic retinopathy: potential systemic and retinal-specific effect of lipid-lowering therapies Diabetologia

Abstract The metabolically active retina obtains essential lipids by endogenous biosynthesis and from the systemic circulation. Clinical studies provide limited and sometimes conflicting evidence as to the relationships between circulating lipid levels and the development and progression of (...)

10 February

Diabetologia http://link.springer.com/

00:00
Early DNA methylation changes in children developing beta cell autoimmunity at a young age Diabetologia

Abstract Aims/hypothesis Type 1 diabetes is a chronic autoimmune disease of complex aetiology, including a potential role for epigenetic regulation. Previous epigenomic studies focused mainly on clinically diagnosed individuals. The aim of the study was to assess early DNA methylation changes (...)

9 February

Diabetologia http://link.springer.com/

00:00
Effectiveness of continuous glucose monitoring in maintaining glycaemic control among people with type 1 diabetes mellitus: a systematic review of randomised controlled trials and meta-analysis Diabetologia

Abstract Aims/hypothesis The aim of this work was to assess the effectiveness of continuous glucose monitoring (CGM) vs self-monitoring of blood glucose (SMBG) in maintaining glycaemic control among people with type 1 diabetes mellitus. Methods Cochrane Library, PubMed, Embase, CINAHL, (...)
00:00
Understanding the pathogenesis of lean non-autoimmune diabetes in an African population with newly diagnosed diabetes Diabetologia

Abstract Aims/hypothesis Apparent type 2 diabetes is increasingly reported in lean adult individuals in sub-Saharan Africa. However, studies undertaking robust clinical and metabolic characterisation of lean individuals with new-onset type 2 diabetes are limited in this population. This (...)

8 February

Diabetologia http://link.springer.com/

00:00
One size does not fit all: an historian’s perspective on precision diabetes medicine Diabetologia

Abstract This article offers an historical approach to exploring precision medicine’s potential for reducing health disparities in diabetes. It examines case studies from the twentieth-century USA, from early twentieth-century beliefs that Jews were most at risk of developing diabetes to claims (...)

7 February

Diabetologia http://link.springer.com/

00:00
Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes Diabetologia

Abstract Aims/hypothesis Type 2 diabetes and atherosclerotic CVD share many risk factors. This study aimed to systematically assess a broad range of continuous traits to separate their direct effects on coronary and peripheral artery disease from those mediated by type 2 diabetes. Methods Our (...)
00:00
Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes Diabetologia

Abstract Aims/hypothesis Type 2 diabetes and atherosclerotic CVD share many risk factors. This study aimed to systematically assess a broad range of continuous traits to separate their direct effects on coronary and peripheral artery disease from those mediated by type 2 diabetes. Methods Our (...)

5 February

Diabetologia http://link.springer.com/

00:00
Proinflammatory cytokines induce rapid, NO-independent apoptosis, expression of chemotactic mediators and interleukin-32 secretion in human pluripotent stem cell-derived beta cells Diabetologia

Abstract Aims/hypothesis The aim of this study was to examine the effects of proinflammatory cytokines on cells of different developmental stages during the generation of stem cell-derived beta cells (SC-beta cells) from human pluripotent stem cells (hPSCs). We wanted to find out to what (...)
00:00
Proinflammatory cytokines induce rapid, NO-independent apoptosis, expression of chemotactic mediators and interleukin-32 secretion in human pluripotent stem cell-derived beta cells Diabetologia

Abstract Aims/hypothesis The aim of this study was to examine the effects of proinflammatory cytokines on cells of different developmental stages during the generation of stem cell-derived beta cells (SC-beta cells) from human pluripotent stem cells (hPSCs). We wanted to find out to what (...)

4 February

Diabetologia http://link.springer.com/

00:00
Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation—relevance for (pre)diabetes: The Maastricht Study Diabetologia

Abstract Aims/hypothesis Biomarkers of endothelial dysfunction and low-grade inflammation are important in the pathogenesis of CVD and can potentially be modified by physical activity and sedentary behaviour. Effects of physical activity on biomarkers of endothelial dysfunction may be (...)
00:00
Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation—relevance for (pre)diabetes: The Maastricht Study Diabetologia

Abstract Aims/hypothesis Biomarkers of endothelial dysfunction and low-grade inflammation are important in the pathogenesis of CVD and can potentially be modified by physical activity and sedentary behaviour. Effects of physical activity on biomarkers of endothelial dysfunction may be (...)

2 February

Diabetologia http://link.springer.com/

00:00
The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day Diabetologia

Abstract Aims/hypothesis In our modern society, artificial light is available around the clock and most people expose themselves to electrical light and light-emissive screens during the dark period of the natural light/dark cycle. Such suboptimal lighting conditions have been associated with (...)
00:00
The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day Diabetologia

Abstract Aims/hypothesis In our modern society, artificial light is available around the clock and most people expose themselves to electrical light and light-emissive screens during the dark period of the natural light/dark cycle. Such suboptimal lighting conditions have been associated with (...)

1 February

Diabetologia http://link.springer.com/

00:00
Breastfeeding and circulating immunological markers during the first 3 years of life: the DIABIMMUNE study Diabetologia

Abstract Aims/hypothesis Our aim was to study the association between duration of breastfeeding and circulating immunological markers during the first 3 years of life in children with HLA-conferred susceptibility to type 1 diabetes. Methods We performed a longitudinal analysis of 38 (...)
00:00
Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle Diabetologia

Abstract Aims/hypothesis Energy-dense nutrition generally induces insulin resistance, but dietary composition may differently affect glucose metabolism. This study investigated initial effects of monounsaturated vs saturated lipid meals on basal and insulin-stimulated myocellular glucose (...)
00:00
Impact of insufficient sleep on dysregulated blood glucose control under standardised meal conditions Diabetologia

Abstract Aims/hypothesis Sleep, diet and exercise are fundamental to metabolic homeostasis. In this secondary analysis of a repeated measures, nutritional intervention study, we tested whether an individual’s sleep quality, duration and timing impact glycaemic response to a breakfast meal the (...)
00:00
Fatty acid-binding protein 4: a key regulator of ketoacidosis in new-onset type 1 diabetes Diabetologia

Abstract Aims/hypothesis Fatty acid-binding protein 4 (FABP4) is an adipokine with a key regulatory role in glucose and lipid metabolism. We prospectively evaluated the role of FABP4 in the pathophysiology of diabetic ketoacidosis (DKA) in new-onset type 1 diabetes. Methods Clinical and (...)
00:00
Relative leucocyte telomere length is associated with incident end-stage kidney disease and rapid decline of kidney function in type 2 diabetes: analysis from the Hong Kong Diabetes Register Diabetologia

Abstract Aims/hypothesis Few large-scale prospective studies have investigated associations between relative leucocyte telomere length (rLTL) and kidney dysfunction in individuals with type 2 diabetes. We examined relationships between rLTL and incident end-stage kidney disease (ESKD) and the (...)
00:00
Environmental risk factors of type 2 diabetes—an exposome approach Diabetologia

Abstract Type 2 diabetes is one of the major chronic diseases accounting for a substantial proportion of disease burden in Western countries. The majority of the burden of type 2 diabetes is attributed to environmental risks and modifiable risk factors such as lifestyle. The environment we (...)
00:00
Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies Diabetologia

Abstract Aims/hypothesis The term prediabetes is used for individuals who have impaired glucose metabolism whose glucose or HbA1c levels are not yet high enough to be diagnosed as diabetes. Prediabetes may already be associated with an increased risk of chronic ‘diabetes-related’ complications. (...)
00:00
Lipoprotein particle sizes and incident type 2 diabetes: the PREVEND cohort study Diabetologia
00:00
Up front Diabetologia
00:00
A PSAD Group response to the consensus report on the definition and interpretation of remission in type 2 diabetes: a psychosocial perspective is needed Diabetologia
00:00
Systematic genetic testing for recessively inherited monogenic diabetes: a cross-sectional study in paediatric diabetes clinics Diabetologia

Abstract Aims/hypothesis Current clinical guidelines for childhood-onset monogenic diabetes outside infancy are mainly focused on identifying and testing for dominantly inherited, predominantly MODY genes. There are no systematic studies of the recessively inherited causes of monogenic (...)
00:00
Individualised screening of diabetic foot: creation of a prediction model based on penalised regression and assessment of theoretical efficacy Diabetologia

Abstract Aims/hypothesis A large proportion of people with diabetes do not receive proper foot screening due to insufficiencies in healthcare systems. Introducing an effective risk prediction model into the screening protocol would potentially reduce the required screening frequency for those (...)
00:00
Associations of plasma glycerophospholipid profile with modifiable lifestyles and incident diabetes in middle-aged and older Chinese Diabetologia

Abstract Aims/hypothesis Glycerophospholipid (GPL) perturbance was linked to the pathogenesis of diabetes in animal studies but prospective studies in humans are rare, particularly in Asians. We aimed to investigate the associations between plasma GPLs and incident diabetes and to explore (...)
00:00
Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes Diabetologia

Abstract Aims/hypothesis Slow progressors to type 1 diabetes are individuals positive for multiple pancreatic islet autoantibodies who have remained diabetes-free for at least 10 years; regulation of the autoimmune response is understudied in this group. Here, we profile CD4+ regulatory T (...)
00:00
Use of electronic patient data overview with alerts in primary care increases prescribing of lipid-lowering medications in patients with type 2 diabetes Diabetologia

Abstract Aims/hypothesis We aimed to assess whether general practices (GPs) using an electronic disease management program (DMP) with population overviews, including alerts when patients failed to receive guideline-recommended prescription medications, increased prescriptions of lipid-lowering (...)
00:00
Upregulation of HLA class II in pancreatic beta cells from organ donors with type 1 diabetes Diabetologia

Abstract Aims/hypothesis We aimed to characterise and quantify the expression of HLA class II (HLA-II) in human pancreatic tissue sections and to analyse its induction in human islets. Methods We immunostained human pancreatic tissue sections from non-diabetic (n = 5), autoantibody positive (...)
00:00
Lipoprotein particle sizes and incident type 2 diabetes: the PREVEND cohort study Diabetologia
00:00
Up front Diabetologia
00:00
A PSAD Group response to the consensus report on the definition and interpretation of remission in type 2 diabetes: a psychosocial perspective is needed Diabetologia
00:00
Systematic genetic testing for recessively inherited monogenic diabetes: a cross-sectional study in paediatric diabetes clinics Diabetologia

Abstract Aims/hypothesis Current clinical guidelines for childhood-onset monogenic diabetes outside infancy are mainly focused on identifying and testing for dominantly inherited, predominantly MODY genes. There are no systematic studies of the recessively inherited causes of monogenic (...)
00:00
Individualised screening of diabetic foot: creation of a prediction model based on penalised regression and assessment of theoretical efficacy Diabetologia

Abstract Aims/hypothesis A large proportion of people with diabetes do not receive proper foot screening due to insufficiencies in healthcare systems. Introducing an effective risk prediction model into the screening protocol would potentially reduce the required screening frequency for those (...)
00:00
Associations of plasma glycerophospholipid profile with modifiable lifestyles and incident diabetes in middle-aged and older Chinese Diabetologia

Abstract Aims/hypothesis Glycerophospholipid (GPL) perturbance was linked to the pathogenesis of diabetes in animal studies but prospective studies in humans are rare, particularly in Asians. We aimed to investigate the associations between plasma GPLs and incident diabetes and to explore (...)
00:00
Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes Diabetologia

Abstract Aims/hypothesis Slow progressors to type 1 diabetes are individuals positive for multiple pancreatic islet autoantibodies who have remained diabetes-free for at least 10 years; regulation of the autoimmune response is understudied in this group. Here, we profile CD4+ regulatory T (...)
00:00
Use of electronic patient data overview with alerts in primary care increases prescribing of lipid-lowering medications in patients with type 2 diabetes Diabetologia

Abstract Aims/hypothesis We aimed to assess whether general practices (GPs) using an electronic disease management program (DMP) with population overviews, including alerts when patients failed to receive guideline-recommended prescription medications, increased prescriptions of lipid-lowering (...)
00:00
Upregulation of HLA class II in pancreatic beta cells from organ donors with type 1 diabetes Diabetologia

Abstract Aims/hypothesis We aimed to characterise and quantify the expression of HLA class II (HLA-II) in human pancreatic tissue sections and to analyse its induction in human islets. Methods We immunostained human pancreatic tissue sections from non-diabetic (n = 5), autoantibody positive (...)
00:00
Breastfeeding and circulating immunological markers during the first 3 years of life: the DIABIMMUNE study Diabetologia

Abstract Aims/hypothesis Our aim was to study the association between duration of breastfeeding and circulating immunological markers during the first 3 years of life in children with HLA-conferred susceptibility to type 1 diabetes. Methods We performed a longitudinal analysis of 38 (...)
00:00
Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle Diabetologia

Abstract Aims/hypothesis Energy-dense nutrition generally induces insulin resistance, but dietary composition may differently affect glucose metabolism. This study investigated initial effects of monounsaturated vs saturated lipid meals on basal and insulin-stimulated myocellular glucose (...)
00:00
Impact of insufficient sleep on dysregulated blood glucose control under standardised meal conditions Diabetologia

Abstract Aims/hypothesis Sleep, diet and exercise are fundamental to metabolic homeostasis. In this secondary analysis of a repeated measures, nutritional intervention study, we tested whether an individual’s sleep quality, duration and timing impact glycaemic response to a breakfast meal the (...)
00:00
Fatty acid-binding protein 4: a key regulator of ketoacidosis in new-onset type 1 diabetes Diabetologia

Abstract Aims/hypothesis Fatty acid-binding protein 4 (FABP4) is an adipokine with a key regulatory role in glucose and lipid metabolism. We prospectively evaluated the role of FABP4 in the pathophysiology of diabetic ketoacidosis (DKA) in new-onset type 1 diabetes. Methods Clinical and (...)
00:00
Relative leucocyte telomere length is associated with incident end-stage kidney disease and rapid decline of kidney function in type 2 diabetes: analysis from the Hong Kong Diabetes Register Diabetologia

Abstract Aims/hypothesis Few large-scale prospective studies have investigated associations between relative leucocyte telomere length (rLTL) and kidney dysfunction in individuals with type 2 diabetes. We examined relationships between rLTL and incident end-stage kidney disease (ESKD) and the (...)
00:00
Environmental risk factors of type 2 diabetes—an exposome approach Diabetologia

Abstract Type 2 diabetes is one of the major chronic diseases accounting for a substantial proportion of disease burden in Western countries. The majority of the burden of type 2 diabetes is attributed to environmental risks and modifiable risk factors such as lifestyle. The environment we (...)
00:00
Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies Diabetologia

Abstract Aims/hypothesis The term prediabetes is used for individuals who have impaired glucose metabolism whose glucose or HbA1c levels are not yet high enough to be diagnosed as diabetes. Prediabetes may already be associated with an increased risk of chronic ‘diabetes-related’ complications. (...)

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17 May

12 May

11 May

5 May

4 May

1 May

30 April

28 April

27 April

26 April

21 April

14 April

12 April

11 April

8 April

5 April

1 April

24 March

23 March

22 March

21 March

19 March

16 March

15 March

11 March

9 March

5 March

4 March

3 March

1 March

25 February

23 February

22 February

19 February

15 February