1 July

Diabetologia http://link.springer.com/

• 00:00
  Up Front Diabetologia
• 00:00
  Healthful eating patterns, serum metabolite profile and risk of diabetes in a population-based prospective study of US Hispanics/Latinos Diabetologia
  Abstract Aims/hypothesis We aimed to evaluate associations of multiple recommended dietary patterns (i.e. the alternate Mediterranean diet [aMED], the Healthy Eating Index [HEI]-2015 and the healthful Plant-based Diet Index [hPDI]) with serum metabolite profile, and to examine (...)
• 00:00
  Unravelling innervation of pancreatic islets Diabetologia
  Abstract The central and peripheral nervous systems play critical roles in regulating pancreatic islet function and glucose metabolism. Over the last century, in vitro and in vivo studies along with examination of human pancreas samples have revealed the structure of islet innervation, (...)
• 00:00
  Association of gut microbiota with glycaemic traits and incident type 2 diabetes, and modulation by habitual diet: a population-based longitudinal cohort study in Chinese adults Diabetologia
  Abstract Aims/hypothesis The gut microbiome is mainly shaped by diet, and varies across geographical regions. Little is known about the longitudinal association of gut microbiota with glycaemic control. We aimed to identify gut microbiota prospectively associated with glycaemic traits and type (...)

30 June

Diabetologia http://link.springer.com/

• 00:00
  A genome-wide cross-trait analysis identifies shared loci and causal relationships of type 2 diabetes and glycaemic traits with polycystic ovary syndrome Diabetologia
  Abstract Aims/hypothesis The link underlying abnormal glucose metabolism, type 2 diabetes and polycystic ovary syndrome (PCOS) that is independent of BMI remains unclear in observational studies. We aimed to clarify this association using a genome-wide cross-trait approach. Methods Summary (...)
• 00:00
  Gut microbiota mediate melatonin signalling in association with type 2 diabetes Diabetologia
  Abstract Aims/hypothesis It has been shown that melatonin plays a general beneficial role in type 2 diabetes in rodents but its role in humans is controversial. In the present study, we investigated the association between serum melatonin and type 2 diabetes risk in a southern Chinese (...)

28 June

Diabetologia http://link.springer.com/

• 00:00
  Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease Diabetologia
  Abstract Aims/hypothesis Diabetic kidney disease (DKD) is the leading cause of kidney failure and has a substantial genetic component. Our aim was to identify novel genetic factors and genes contributing to DKD by performing meta-analysis of previous genome-wide association studies (GWAS) on (...)
• 00:00
  Clinical variable-based cluster analysis identifies novel subgroups with a distinct genetic signature, lipidomic pattern and cardio-renal risks in Asian patients with recent-onset type 2 diabetes Diabetologia
  Abstract Aims/hypothesis We sought to subtype South East Asian patients with type 2 diabetes by de novo cluster analysis on clinical variables, and to determine whether the novel subgroups carry distinct genetic and lipidomic features as well as differential cardio-renal risks. Methods (...)

24 June

Diabetologia http://link.springer.com/

• 00:00
  Continuous glucose monitoring and hypoglycaemia events: unmet needs. Reply to Papaioannou TG, Snoudou D and Tsiofis C [letter] Diabetologia
• 00:00
  A roadmap to achieve pharmacological precision medicine in diabetes Diabetologia
  Abstract Current pharmacological treatment of diabetes is largely algorithmic. Other than for cardiovascular disease or renal disease, where sodium–glucose cotransporter 2 inhibitors and/or glucagon-like peptide-1 receptor agonists are indicated, the choice of treatment is based upon overall (...)

23 June

Diabetologia http://link.springer.com/

• 00:00
  Continuous glucose monitoring and hypoglycaemia events: unmet needs Diabetologia

22 June

Diabetologia http://link.springer.com/

• 00:00
  The role of mental disorders in precision medicine for diabetes: a narrative review Diabetologia
  Abstract This narrative review aims to examine the value of addressing mental disorders as part of the care of people with type 1 and type 2 diabetes in terms of four components of precision medicine. First, we review the empirical literature on the role of common mental disorders in the (...)

21 June

Diabetologia http://link.springer.com/

• 00:00
  Up Front Diabetologia
• 00:00
  Precision prognostics for the development of complications in diabetes Diabetologia
  Abstract Individuals with diabetes face higher risks for macro- and microvascular complications than their non-diabetic counterparts. The concept of precision medicine in diabetes aims to optimise treatment decisions for individual patients to reduce the risk of major diabetic complications, (...)

20 June

Diabetologia http://link.springer.com/

• 00:00
  Correction to: Association of gut microbiota with glycaemic traits and incident type 2 diabetes, and modulation by habitual diet: a population-based longitudinal cohort study in Chinese adults Diabetologia

18 June

Diabetologia http://link.springer.com/

• 00:00
  Umbilical cord blood DNA methylation in children who later develop type 1 diabetes Diabetologia
  Abstract Aims/hypothesis Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA methylation is associated with later progression to type 1 diabetes. Methods Reduced (...)

16 June

Diabetologia http://link.springer.com/

• 00:00
  A miR-125/Sirtuin-7 pathway drives the pro-calcific potential of myeloid cells in diabetic vascular disease Diabetologia
  Abstract Aims/hypothesis Ectopic calcification is a typical feature of diabetic vascular disease and resembles an accelerated ageing phenotype. We previously found an excess of myeloid calcifying cells in diabetic individuals. We herein examined molecular and cellular pathways linking (...)
• 00:00
  Exploring ethnic representativeness in diabetes clinical trial enrolment from 2000 to 2020: a chronological survey Diabetologia
  Abstract Aims/hypothesis Ethnic representativeness of participant enrolment in diabetes RCTs involving multiple ethnicities remains unknown. The aims of this study were to evaluate the status and temporal trend of ethnic representativeness in enrolment to diabetes RCTs, and to assess (...)

15 June

Diabetologia http://link.springer.com/

• 00:00
  Impact of diabetes on COVID-19 prognosis beyond comorbidity burden: the CORONADO initiative Diabetologia
  Abstract Aims/hypothesis Diabetes has been recognised as a pejorative prognostic factor in coronavirus disease 2019 (COVID-19). Since diabetes is typically a disease of advanced age, it remains unclear whether diabetes remains a COVID-19 risk factor beyond advanced age and associated (...)

10 June

Diabetologia http://link.springer.com/

• 00:00
  GLP-1 receptor nitration contributes to loss of brain pericyte function in a mouse model of diabetes Diabetologia
  Abstract Aims/hypothesis We have previously shown that diabetes causes pericyte dysfunction, leading to loss of vascular integrity and vascular cognitive impairment and dementia (VCID). Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs), used in managing type 2 diabetes mellitus, (...)

5 June

Diabetologia http://link.springer.com/

• 00:00
  Obesity in late adolescence and incident type 1 diabetes in young adulthood Diabetologia
  Abstract Aims/hypothesis Studies in children have reported an association between increased BMI and risk for developing type 1 diabetes, but evidence in late adolescence is limited. We studied the association between BMI in late adolescence and incident type 1 diabetes in young adulthood. (...)

2 June

Diabetologia http://link.springer.com/

• 00:00
  Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes is characterised by hyperglucagonaemia and perturbed function of pancreatic glucagon-secreting alpha cells but the molecular mechanisms contributing to these phenotypes are poorly understood. Insulin-degrading enzyme (IDE) is present within all islet (...)
• 00:00
  Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes is characterised by hyperglucagonaemia and perturbed function of pancreatic glucagon-secreting alpha cells but the molecular mechanisms contributing to these phenotypes are poorly understood. Insulin-degrading enzyme (IDE) is present within all islet (...)

1 June

Diabetologia http://link.springer.com/

• 00:00
  Correction to: Defining the underlying defect in insulin action in type 2 diabetes Diabetologia
• 00:00
  Correction to: The suitability of patient-reported outcome measures used to assess the impact of hypoglycaemia on quality of life in people with diabetes: a systematic review using COSMIN methods Diabetologia
• 00:00
  Long-term outcomes of dietary carbohydrate restriction for HbA1c reduction in type 2 diabetes mellitus are needed Diabetologia
• 00:00
  Long-term outcomes of dietary carbohydrate restriction for HbA1c reduction in type 2 diabetes mellitus are needed. Reply to Kang J and Ma E [letter] Diabetologia
• 00:00
  Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats Diabetologia
  Abstract Aim/hypothesis Urocortin-3 (UCN3) is a glucoregulatory peptide produced in the gut and pancreatic islets. The aim of this study was to clarify the acute effects of UCN3 on glucose regulation following an oral glucose challenge and to investigate the mechanisms involved. Methods We (...)
• 00:00
  Mortality trends in type 1 diabetes: a multicountry analysis of six population-based cohorts Diabetologia
  Abstract Aims/hypothesis Mortality has declined in people with type 1 diabetes in recent decades. We examined how the pattern of decline differs by country, age and sex, and how mortality trends in type 1 diabetes relate to trends in general population mortality. Methods We assembled (...)
• 00:00
  XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice Diabetologia
  Abstract Aims/hypothesis Pancreatic beta cell dedifferentiation, transdifferentiation into other islet cells and apoptosis have been implicated in beta cell failure in type 2 diabetes, although the mechanisms are poorly defined. The endoplasmic reticulum stress response factor X-box binding (...)
• 00:00
  Characteristics of adults with type 1 diabetes and treatment-resistant problematic hypoglycaemia: a baseline analysis from the HARPdoc RCT Diabetologia
  Abstract Aims/hypothesis Problematic hypoglycaemia still complicates insulin therapy for some with type 1 diabetes. This study describes baseline emotional, cognitive and behavioural characteristics in participants in the HARPdoc trial, which evaluates a novel intervention for (...)
• 00:00
  Maturation of beta cells: lessons from in vivo and in vitro models Diabetologia
  Abstract The ability to maintain normoglycaemia, through glucose-sensitive insulin release, is a key aspect of postnatal beta cell function. However, terminally differentiated beta cell identity does not necessarily imply functional maturity. Beta cell maturation is therefore a continuation of (...)
• 00:00
  Mucosal-associated invariant T cells are associated with insulin resistance in childhood obesity, and disrupt insulin signalling via IL-17 Diabetologia
  Abstract Aims/hypothesis Mucosal-associated invariant T cells (MAIT cells) are an abundant population of innate T cells. When activated, MAIT cells rapidly produce a range of cytokines, including IFN?, TNF-? and IL-17. Several studies have implicated MAIT cells in the development of metabolic (...)
• 00:00
  Long-term outcomes of dietary carbohydrate restriction for HbA1c reduction in type 2 diabetes mellitus are needed Diabetologia

24 May

Diabetologia http://link.springer.com/

• 00:00
  Risk of incident obstructive sleep apnoea in patients with type 1 diabetes: a population-based retrospective cohort study Diabetologia
  Abstract Aims/hypothesis People with type 2 diabetes are at increased risk of developing obstructive sleep apnoea. However, it is not known whether people with type 1 diabetes are also at an increased risk of obstructive sleep apnoea. This study aimed to examine whether people with type 1 (...)

20 May

Diabetologia http://link.springer.com/

• 00:00
  Precision nutrition in diabetes: when population-based dietary advice gets personal Diabetologia
  Abstract Diet plays a fundamental role in maintaining long-term health, with healthful diets being endorsed by current dietary guidelines for the prevention and management of type 2 diabetes. However, the response to dietary interventions varies widely, highlighting the need for refinement and (...)

19 May

Diabetologia http://link.springer.com/

• 00:00
  Low- and middle-income countries demonstrate rapid growth of type 2 diabetes: an analysis based on Global Burden of Disease 1990–2019 data Diabetologia
  Abstract Aims/hypothesis The study aims to quantify the global trend of the disease burden of type 2 diabetes caused by various risks factors by country income tiers. Methods Data on type 2 diabetes, including mortality and disability-adjusted life years (DALYs) during 1990–2019, were obtained (...)

17 May

Diabetologia http://link.springer.com/

• 00:00
  Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: a systematic review and meta-analysis Diabetologia
  Abstract Aims/hypothesis Tirzepatide is a novel dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) currently under review for marketing approval. Individual trials have assessed the clinical profile of tirzepatide vs different (...)
• 00:00
  Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: a systematic review and meta-analysis Diabetologia
  Abstract Aims/hypothesis Tirzepatide is a novel dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) currently under review for marketing approval. Individual trials have assessed the clinical profile of tirzepatide vs different (...)

12 May

Diabetologia http://link.springer.com/

• 00:00
  Addition of intermittently scanned continuous glucose monitoring to standard care in a cohort of pregnant women with type 1 diabetes: effect on glycaemic control and pregnancy outcomes Diabetologia
  Abstract Aims/hypothesis The aim of this study was to assess whether the addition of intermittently scanned continuous glucose monitoring (isCGM) to standard care (self-monitoring of blood glucose [SMBG] alone) improves glycaemic control and pregnancy outcomes in women with type 1 diabetes and (...)

11 May

Diabetologia http://link.springer.com/

• 00:00
  Health impact of seven herpesviruses on (pre)diabetes incidence and HbA1c: results from the KORA cohort Diabetologia
  Abstract Aims/hypothesis The prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are seropositive for herpesviruses. This study examines the prospective association of herpesviruses with (pre)diabetes to evaluate their (...)

5 May

Diabetologia http://link.springer.com/

• 00:00
  Human adipose-derived mesenchymal stem cells prevent type 1 diabetes induced by immune checkpoint blockade Diabetologia
  Abstract Aims/hypothesis Immunomodulators blocking cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) or programmed death-ligand 1 (PD-L1) have improved the treatment of a broad spectrum of cancers. These immune checkpoint inhibitors (ICIs) (...)
• 00:00
  Human adipose-derived mesenchymal stem cells prevent type 1 diabetes induced by immune checkpoint blockade Diabetologia
  Abstract Aims/hypothesis Immunomodulators blocking cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) or programmed death-ligand 1 (PD-L1) have improved the treatment of a broad spectrum of cancers. These immune checkpoint inhibitors (ICIs) (...)

4 May

Diabetologia http://link.springer.com/

• 00:00
  Insulin allergy: a diagnostic and therapeutic strategy based on a retrospective cohort and a case–control study Diabetologia
  Abstract Aims/hypothesis Insulin allergy is a rare but significant clinical challenge. We aimed to develop a management workflow by (1) validating clinical criteria to guide diagnosis, based on a retrospective cohort, and (2) assessing the diagnostic performance of confirmatory tests, based on (...)

1 May

Diabetologia http://link.springer.com/

• 00:00
  Correction to: A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY Diabetologia
• 00:00
  Ertugliflozin, renoprotection and potential confounding by muscle wasting Diabetologia
• 00:00
  Urinary albumin/creatinine ratio tertiles predict risk of diabetic retinopathy progression: a natural history study from the Adolescent Cardio-Renal Intervention Trial (AdDIT) observational cohort Diabetologia
  Abstract Aims/hypothesis We hypothesised that adolescents with type 1 diabetes with a urinary albumin/creatinine ratio (ACR) in the upper tertile of the normal range (high ACR) are at greater risk of three-step diabetic retinopathy progression (3DR) independent of glycaemic control. Methods (...)
• 00:00
  Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes is a complex metabolic disease with increasing prevalence worldwide. Improving the prediction of incident type 2 diabetes using epigenetic markers could help tailor prevention efforts to those at the highest risk. The aim of this study was to identify (...)
• 00:00
  Ertugliflozin, renoprotection and potential confounding by muscle wasting. Reply to Groothof D, Post A, Gans ROB et al [letter] Diabetologia
• 00:00
  Early DNA methylation changes in children developing beta cell autoimmunity at a young age Diabetologia
  Abstract Aims/hypothesis Type 1 diabetes is a chronic autoimmune disease of complex aetiology, including a potential role for epigenetic regulation. Previous epigenomic studies focused mainly on clinically diagnosed individuals. The aim of the study was to assess early DNA methylation changes (...)
• 00:00
  Spatial and transcriptional heterogeneity of pancreatic beta cell neogenesis revealed by a time-resolved reporter system Diabetologia
  Abstract Aims/hypothesis While pancreatic beta cells have been shown to originate from endocrine progenitors in ductal regions, it remains unclear precisely where beta cells emerge from and which transcripts define newborn beta cells. We therefore investigated characteristics of newborn beta (...)
• 00:00
  Prediabetes blunts DPP4 genetic control of postprandial glycaemia and insulin secretion Diabetologia
  Abstract Aims/hypothesis Imbalances in glucose metabolism are hallmarks of clinically silent prediabetes (defined as impaired fasting glucose and/or impaired glucose tolerance) representing dysmetabolism trajectories leading to type 2 diabetes. CD26/dipeptidyl peptidase 4 (DPP4) is a (...)
• 00:00
  Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice Diabetologia
  Abstract Aims/hypothesis Diabetic cardiomyopathy (DCM) is a serious and under-recognised complication of diabetes. The first sign is diastolic dysfunction, which progresses to heart failure. The pathophysiology of DCM is incompletely understood but microcirculatory changes are important. (...)
• 00:00
  Familial aggregation and shared genetic loading for major psychiatric disorders and type 2 diabetes Diabetologia
  Abstract Aims/hypothesis Psychiatric disorders, such as schizophrenia (SCZ), major depressive disorder (MDD) and bipolar disorder (BPD), are highly comorbid with type 2 diabetes. However, the mechanisms underlying such comorbidity are understudied. This study explored the familial aggregation (...)
• 00:00
  Ertugliflozin, renoprotection and potential confounding by muscle wasting Diabetologia

30 April

Diabetologia http://link.springer.com/

• 00:00
  Congenital beta cell defects are not associated with markers of islet autoimmunity, even in the context of high genetic risk for type 1 diabetes Diabetologia
  Abstract Aims/hypothesis A key unanswered question in type 1 diabetes is whether beta cells initiate their own destruction or are victims of an aberrant immune response (beta cell suicide or homicide?). To investigate this, we assessed islet autoantibodies in individuals with congenital beta (...)
• 00:00
  Genetic risk of type 2 diabetes modifies the effects of a lifestyle intervention aimed at the prevention of gestational and postpartum diabetes Diabetologia
  Abstract Aims/hypothesis The aim of this study was to assess the interaction between genetic risk and lifestyle intervention on the occurrence of gestational diabetes mellitus (GDM) and postpartum diabetes. Methods The RADIEL study is an RCT aimed at prevention of GDM and postpartum diabetes (...)
• 00:00
  Early vs late histological confirmation of coeliac disease in children with new-onset type 1 diabetes Diabetologia
  Abstract Aim Screening for coeliac disease in asymptomatic children with new-onset type 1 diabetes is controversial. The aim of this study was to analyse whether the confirmation of coeliac disease in children with new-onset type 1 diabetes and positive screening results can be postponed. (...)
• 00:00
  Paternal eNOS deficiency in mice affects glucose homeostasis and liver glycogen in male offspring without inheritance of eNOS deficiency itself Diabetologia
  Abstract Aims/hypothesis It was shown that maternal endothelial nitric oxide synthase (eNOS) deficiency causes fatty liver disease and numerically lower fasting glucose in female wild-type offspring, suggesting that parental genetic variants may influence the offspring’s phenotype via (...)

28 April

Diabetologia http://link.springer.com/

• 00:00
  Mediators of the association between educational attainment and type 2 diabetes mellitus: a two-step multivariable Mendelian randomisation study Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes mellitus is a major health burden disproportionately affecting those with lower educational attainment (EA). We aimed to obtain causal estimates of the association between EA and type 2 diabetes and to quantify mediating effects of known modifiable risk (...)
• 00:00
  Lessons from single-cell RNA sequencing of human islets Diabetologia
  Abstract Islet dysfunction is central in type 2 diabetes and full-blown type 2 diabetes develops first when the beta cells lose their ability to secrete adequate amounts of insulin in response to raised plasma glucose. Several mechanisms behind beta cell dysfunction have been put forward but (...)

27 April

Diabetologia http://link.springer.com/

• 00:00
  The 26RFa (QRFP)/GPR103 neuropeptidergic system in mice relays insulin signalling into the brain to regulate glucose homeostasis Diabetologia
  Abstract Aims/hypothesis 26RFa (pyroglutamilated RFamide peptide [QRFP]) is a biologically active peptide that regulates glucose homeostasis by acting as an incretin and by increasing insulin sensitivity at the periphery. 26RFa is also produced by a neuronal population localised in the (...)

26 April

Diabetologia http://link.springer.com/

• 00:00
  Correction to: Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function Diabetologia

21 April

Diabetologia http://link.springer.com/

• 00:00
  Effect of dapagliflozin on kidney and cardiovascular outcomes by baseline KDIGO risk categories: a post hoc analysis of the DAPA-CKD trial Diabetologia
  Abstract Aims/hypothesis In the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) trial, dapagliflozin reduced the risks of progressive kidney disease, hospitalised heart failure or cardiovascular death, and death from all causes in patients with chronic (...)
• 00:00
  Sleep deprivation prevents counterregulatory adaptation to recurrent hypoglycaemia Diabetologia
  Abstract Aims/hypothesis Attenuated counterregulation after recurrent hypoglycaemia is a major complication of diabetes treatment. As there is previous evidence for the relevance of sleep in metabolic control, we assessed the acute contribution of sleep to the counterregulatory adaptation to (...)

14 April

Diabetologia http://link.springer.com/

• 00:00
  Up Front Diabetologia
• 00:00
  Up Front Diabetologia

12 April

Diabetologia http://link.springer.com/

• 00:00
  Where to for precision treatment of HNF1A-MODY? Diabetologia
• 00:00
  Incident cardiovascular disease by clustering of favourable risk factors in type 1 diabetes: the EURODIAB Prospective Complications Study Diabetologia
  Abstract Aims The aim of this prospective study was to examine CVD risk reduction in type 1 diabetes (1) for people with favourable cardiovascular health metrics and (2) by clustering of these metrics. Methods Data from 2313 participants from the EURODIAB Prospective Complications Study were (...)
• 00:00
  Where to for precision treatment of HNF1A-MODY? Diabetologia
• 00:00
  Incident cardiovascular disease by clustering of favourable risk factors in type 1 diabetes: the EURODIAB Prospective Complications Study Diabetologia
  Abstract Aims The aim of this prospective study was to examine CVD risk reduction in type 1 diabetes (1) for people with favourable cardiovascular health metrics and (2) by clustering of these metrics. Methods Data from 2313 participants from the EURODIAB Prospective Complications Study were (...)

11 April

Diabetologia http://link.springer.com/

• 00:00
  Per- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN) Diabetologia
  Abstract Aims/hypothesis Diabetogenic effects of per- and polyfluoroalkyl substances (PFAS) have been suggested. However, evidence based on prospective cohort studies is limited. We examined the association between serum PFAS concentrations and incident diabetes in the Study of Women’s Health (...)
• 00:00
  Per- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN) Diabetologia
  Abstract Aims/hypothesis Diabetogenic effects of per- and polyfluoroalkyl substances (PFAS) have been suggested. However, evidence based on prospective cohort studies is limited. We examined the association between serum PFAS concentrations and incident diabetes in the Study of Women’s Health (...)

8 April

Diabetologia http://link.springer.com/

• 00:00
  Plasma metabolite profiles related to plant-based diets and the risk of type 2 diabetes Diabetologia
  Abstract Aims/hypothesis Plant-based diets, especially when rich in healthy plant foods, have been associated with a lower risk of type 2 diabetes. However, whether plasma metabolite profiles related to plant-based diets reflect this association was unknown. The aim of this study was to (...)

5 April

Diabetologia http://link.springer.com/

• 00:00
  Coordination of glucose monitoring, self-care behaviour and mental health: achieving precision monitoring in diabetes Diabetologia
  Abstract Monitoring of glucose plays an essential role in the management of diabetes. However, to fully understand and meaningfully interpret glucose levels, additional information on context is necessary. Important contextual factors include data on behaviours such as eating, exercise, (...)
• 00:00
  Elevated cerebrospinal fluid glucose levels and diabetes mellitus are associated with activation of the neurotoxic polyol pathway Diabetologia
  Abstract Aims/hypothesis During hyperglycaemia, some glucose bypasses glycolysis and is metabolised via the potentially neurotoxic polyol pathway, in which glucose is metabolised to sorbitol and fructose. Increased polyol concentrations have been demonstrated in the cerebrospinal fluid (CSF) (...)

1 April

Diabetologia http://link.springer.com/

• 00:00
  Long-term outcomes of dietary carbohydrate restriction for HbA1c reduction in type 2 diabetes mellitus are needed. Reply to Kang J and Ma E [letter] Diabetologia
• 00:00
  Up front Diabetologia
• 00:00
  Understanding the pathogenesis of lean non-autoimmune diabetes in an African population with newly diagnosed diabetes Diabetologia
  Abstract Aims/hypothesis Apparent type 2 diabetes is increasingly reported in lean adult individuals in sub-Saharan Africa. However, studies undertaking robust clinical and metabolic characterisation of lean individuals with new-onset type 2 diabetes are limited in this population. This (...)
• 00:00
  Lipids, hyperreflective crystalline deposits and diabetic retinopathy: potential systemic and retinal-specific effect of lipid-lowering therapies Diabetologia
  Abstract The metabolically active retina obtains essential lipids by endogenous biosynthesis and from the systemic circulation. Clinical studies provide limited and sometimes conflicting evidence as to the relationships between circulating lipid levels and the development and progression of (...)
• 00:00
  Using genetics to assess the association of commonly used antihypertensive drugs with diabetes, glycaemic traits and lipids: a trans-ancestry Mendelian randomisation study Diabetologia
  Abstract Aims/hypothesis Diabetes and hyperlipidaemia are common comorbidities in people with hypertension. Despite similar protective effects on CVD, different classes of antihypertensive drugs have different effects on CVD risk factors, including diabetes, glucose metabolism and lipids. (...)
• 00:00
  Effectiveness of continuous glucose monitoring in maintaining glycaemic control among people with type 1 diabetes mellitus: a systematic review of randomised controlled trials and meta-analysis Diabetologia
  Abstract Aims/hypothesis The aim of this work was to assess the effectiveness of continuous glucose monitoring (CGM) vs self-monitoring of blood glucose (SMBG) in maintaining glycaemic control among people with type 1 diabetes mellitus. Methods Cochrane Library, PubMed, Embase, CINAHL, (...)
• 00:00
  A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY Diabetologia
  Abstract Aims/hypothesis Systematic studies on the phenotypic consequences of variants causal of HNF1A-MODY are rare. Our aim was to assess the phenotype of carriers of a single HNF1A variant and genetic and clinical factors affecting the clinical spectrum. Methods We conducted a family-based (...)
• 00:00
  Adiponectin deficiency induces hepatic steatosis during pregnancy and gestational diabetes in mice Diabetologia
  Abstract Aims/hypothesis Obesity and hepatic steatosis are risk factors for gestational diabetes mellitus (GDM), a common complication of pregnancy. Adiponectin is a fat-derived hormone that improves hepatic steatosis and insulin sensitivity. Low levels of circulating adiponectin are (...)
• 00:00
  A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY Diabetologia
  Abstract Aims/hypothesis Systematic studies on the phenotypic consequences of variants causal of HNF1A-MODY are rare. Our aim was to assess the phenotype of carriers of a single HNF1A variant and genetic and clinical factors affecting the clinical spectrum. Methods We conducted a family-based (...)

24 March

Diabetologia http://link.springer.com/

• 00:00
  Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats Diabetologia
  Abstract Aim/hypothesis Urocortin-3 (UCN3) is a glucoregulatory peptide produced in the gut and pancreatic islets. The aim of this study was to clarify the acute effects of UCN3 on glucose regulation following an oral glucose challenge and to investigate the mechanisms involved. Methods We (...)
• 00:00
  Characteristics of adults with type 1 diabetes and treatment-resistant problematic hypoglycaemia: a baseline analysis from the HARPdoc RCT Diabetologia
  Abstract Aims/hypothesis Problematic hypoglycaemia still complicates insulin therapy for some with type 1 diabetes. This study describes baseline emotional, cognitive and behavioural characteristics in participants in the HARPdoc trial, which evaluates a novel intervention for (...)

23 March

Diabetologia http://link.springer.com/

• 00:00
  Correction to: Defining the underlying defect in insulin action in type 2 diabetes Diabetologia
• 00:00
  Correction to: The suitability of patient-reported outcome measures used to assess the impact of hypoglycaemia on quality of life in people with diabetes: a systematic review using COSMIN methods Diabetologia

22 March

Diabetologia http://link.springer.com/

• 00:00
  Mortality trends in type 1 diabetes: a multicountry analysis of six population-based cohorts Diabetologia
  Abstract Aims/hypothesis Mortality has declined in people with type 1 diabetes in recent decades. We examined how the pattern of decline differs by country, age and sex, and how mortality trends in type 1 diabetes relate to trends in general population mortality. Methods We assembled (...)
• 00:00
  XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice Diabetologia
  Abstract Aims/hypothesis Pancreatic beta cell dedifferentiation, transdifferentiation into other islet cells and apoptosis have been implicated in beta cell failure in type 2 diabetes, although the mechanisms are poorly defined. The endoplasmic reticulum stress response factor X-box binding (...)

21 March

Diabetologia http://link.springer.com/

• 00:00
  Pharmacoepigenetics in type 2 diabetes: is it clinically relevant? Diabetologia
  Abstract Data generated over nearly two decades clearly demonstrate the importance of epigenetic modifications and mechanisms in the pathogenesis of type 2 diabetes. However, the role of pharmacoepigenetics in type 2 diabetes is less well established. The field of pharmacoepigenetics covers (...)

19 March

Diabetologia http://link.springer.com/

• 00:00
  Mucosal-associated invariant T cells are associated with insulin resistance in childhood obesity, and disrupt insulin signalling via IL-17 Diabetologia
  Abstract Aims/hypothesis Mucosal-associated invariant T cells (MAIT cells) are an abundant population of innate T cells. When activated, MAIT cells rapidly produce a range of cytokines, including IFN?, TNF-? and IL-17. Several studies have implicated MAIT cells in the development of metabolic (...)

16 March

Diabetologia http://link.springer.com/

• 00:00
  The COVID-19 pandemic may be receding but the diabetes pandemic rages on Diabetologia
• 00:00
  Up Front Diabetologia
• 00:00
  Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase Diabetologia
  Abstract Aims/hypothesis Although targeted in extrapancreatic tissues by several drugs used to treat type 2 diabetes, the role of AMP-activated protein kinase (AMPK) in the control of insulin secretion is still debatable. Previous studies have used pharmacological activators of limited (...)
• 00:00
  Incidence of newly diagnosed diabetes after Covid-19 Diabetologia
  Abstract Aims/hypothesis The aim of this work was to investigate diabetes incidence after infection with coronavirus disease-2019 (Covid-19). Individuals with acute upper respiratory tract infections (AURI), which are frequently caused by viruses, were selected as a non-exposed control group. (...)
• 00:00
  The COVID-19 pandemic may be receding but the diabetes pandemic rages on Diabetologia
• 00:00
  Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase Diabetologia
  Abstract Aims/hypothesis Although targeted in extrapancreatic tissues by several drugs used to treat type 2 diabetes, the role of AMP-activated protein kinase (AMPK) in the control of insulin secretion is still debatable. Previous studies have used pharmacological activators of limited (...)
• 00:00
  Up Front Diabetologia
• 00:00
  Incidence of newly diagnosed diabetes after Covid-19 Diabetologia
  Abstract Aims/hypothesis The aim of this work was to investigate diabetes incidence after infection with coronavirus disease-2019 (Covid-19). Individuals with acute upper respiratory tract infections (AURI), which are frequently caused by viruses, were selected as a non-exposed control group. (...)

15 March

Diabetologia http://link.springer.com/

• 00:00
  Loss of function of renal Glut2 reverses hyperglycaemia and normalises body weight in mouse models of diabetes and obesity Diabetologia
  Abstract Aims/hypothesis Renal GLUT2 is increased in diabetes, thereby enhancing glucose reabsorption and worsening hyperglycaemia. Here, we determined whether loss of Glut2 (also known as Slc2a2) specifically in the kidneys would reverse hyperglycaemia and normalise body weight in mouse (...)
• 00:00
  Loss of function of renal Glut2 reverses hyperglycaemia and normalises body weight in mouse models of diabetes and obesity Diabetologia
  Abstract Aims/hypothesis Renal GLUT2 is increased in diabetes, thereby enhancing glucose reabsorption and worsening hyperglycaemia. Here, we determined whether loss of Glut2 (also known as Slc2a2) specifically in the kidneys would reverse hyperglycaemia and normalise body weight in mouse (...)

11 March

Diabetologia http://link.springer.com/

• 00:00
  Diabetes, GDF-15 and incident heart failure: the atherosclerosis risk in communities study Diabetologia
  Abstract Aims/hypothesis Elevated circulating growth differentiation factor-15 (GDF-15), a marker of cellular stress, is associated with both heart failure (HF) and diabetes. However, it is unclear to what extent GDF-15 is associated with HF among individuals with and without diabetes. Methods (...)
• 00:00
  The insulin market reaches 100 Diabetologia
• 00:00
  High-intensity interval training for 12 weeks improves cardiovascular autonomic function but not somatosensory nerve function and structure in overweight men with type 2 diabetes Diabetologia
  Abstract Aims/hypothesis It remains unclear whether and which modality of exercise training as a component of lifestyle intervention may exert favourable effects on somatosensory and autonomic nerve tests in people with type 2 diabetes. Methods Cardiovascular autonomic and somatosensory nerve (...)
• 00:00
  Diabetes, GDF-15 and incident heart failure: the atherosclerosis risk in communities study Diabetologia
  Abstract Aims/hypothesis Elevated circulating growth differentiation factor-15 (GDF-15), a marker of cellular stress, is associated with both heart failure (HF) and diabetes. However, it is unclear to what extent GDF-15 is associated with HF among individuals with and without diabetes. Methods (...)
• 00:00
  The insulin market reaches 100 Diabetologia
• 00:00
  High-intensity interval training for 12 weeks improves cardiovascular autonomic function but not somatosensory nerve function and structure in overweight men with type 2 diabetes Diabetologia
  Abstract Aims/hypothesis It remains unclear whether and which modality of exercise training as a component of lifestyle intervention may exert favourable effects on somatosensory and autonomic nerve tests in people with type 2 diabetes. Methods Cardiovascular autonomic and somatosensory nerve (...)

9 March

Diabetologia http://link.springer.com/

• 00:00
  Referees 2021 Diabetologia
• 00:00
  Referees 2021 Diabetologia

5 March

Diabetologia http://link.springer.com/

• 00:00
  Reversibility of brain glucose kinetics in type 2 diabetes mellitus Diabetologia
  Abstract Aims/hypothesis We have previously shown that individuals with uncontrolled type 2 diabetes have a blunted rise in brain glucose levels measured by 1H magnetic resonance spectroscopy. Here, we investigate whether reductions in HbA1c normalise intracerebral glucose levels. Methods (...)
• 00:00
  Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function Diabetologia
  Abstract Aims/hypothesis South Asians in general, and Asian Indians in particular, have higher risk of type 2 diabetes compared with white Europeans, and a younger age of onset. The reasons for the younger age of onset in relation to obesity, beta cell function and insulin sensitivity are (...)
• 00:00
  Reversibility of brain glucose kinetics in type 2 diabetes mellitus Diabetologia
  Abstract Aims/hypothesis We have previously shown that individuals with uncontrolled type 2 diabetes have a blunted rise in brain glucose levels measured by 1H magnetic resonance spectroscopy. Here, we investigate whether reductions in HbA1c normalise intracerebral glucose levels. Methods (...)
• 00:00
  Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function Diabetologia
  Abstract Aims/hypothesis South Asians in general, and Asian Indians in particular, have higher risk of type 2 diabetes compared with white Europeans, and a younger age of onset. The reasons for the younger age of onset in relation to obesity, beta cell function and insulin sensitivity are (...)

4 March

Diabetologia http://link.springer.com/

• 00:00
  When therapeutic drugs lead to diabetes Diabetologia
  Abstract Drug-induced diabetes mellitus is a growing problem in clinical practice. New, potent medications contribute to this problem in a population already at high risk of developing glucose disturbances because of poor lifestyle habits and high prevalence of being overweight/obese. The (...)
• 00:00
  When therapeutic drugs lead to diabetes Diabetologia
  Abstract Drug-induced diabetes mellitus is a growing problem in clinical practice. New, potent medications contribute to this problem in a population already at high risk of developing glucose disturbances because of poor lifestyle habits and high prevalence of being overweight/obese. The (...)
• 00:00
  Maturation of beta cells: lessons from in vivo and in vitro models Diabetologia
  Abstract The ability to maintain normoglycaemia, through glucose-sensitive insulin release, is a key aspect of postnatal beta cell function. However, terminally differentiated beta cell identity does not necessarily imply functional maturity. Beta cell maturation is therefore a continuation of (...)

3 March

Diabetologia http://link.springer.com/

• 00:00
  Spatial and transcriptional heterogeneity of pancreatic beta cell neogenesis revealed by a time-resolved reporter system Diabetologia
  Abstract Aims/hypothesis While pancreatic beta cells have been shown to originate from endocrine progenitors in ductal regions, it remains unclear precisely where beta cells emerge from and which transcripts define newborn beta cells. We therefore investigated characteristics of newborn beta (...)
• 00:00
  Correction to: A multigenerational study on phenotypic consequences of the most common causal variant of HNF1A-MODY Diabetologia
• 00:00
  Ertugliflozin, renoprotection and potential confounding by muscle wasting. Reply to Groothof D, Post A, Gans ROB et al [letter] Diabetologia

1 March

Diabetologia http://link.springer.com/

• 00:00
  The insulin hypersecretion hypothesis: cause or effect? Reply to Polychronakos C [letter] Diabetologia
• 00:00
  The insulin hypersecretion hypothesis: cause or effect? Diabetologia
• 00:00
  Up Front Diabetologia
• 00:00
  Prevalence of type 2 diabetes in psychiatric disorders: an umbrella review with meta-analysis of 245 observational studies from 32 systematic reviews Diabetologia
  Abstract Aims/hypothesis Estimates of the global prevalence of type 2 diabetes vary between 6% and 9%. The prevalence of type 2 diabetes has been investigated in psychiatric populations but a critical appraisal of the existing evidence is lacking, and an overview is needed. This umbrella (...)
• 00:00
  The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice Diabetologia
  Abstract Aims/hypothesis Second-generation antipsychotic (SGA) drugs have been associated with the development of type 2 diabetes and the metabolic syndrome in patients with schizophrenia. In this study, we aimed to investigate the effects of two different SGA drugs, olanzapine and (...)
• 00:00
  MicroRNA-193b impairs muscle growth in mouse models of type 2 diabetes by targeting the PDK1/Akt signalling pathway Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes is associated with a reduction in skeletal muscle mass; however, how the progression of sarcopenia is induced and regulated remains largely unknown. We aimed to find out whether a specific microRNA (miR) may contribute to skeletal muscle atrophy in type (...)
• 00:00
  Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet Diabetologia
  Abstract Aims/hypothesis Despite a similar fat storing function, visceral (intra-abdominal) white adipose tissue (WAT) is detrimental, whereas subcutaneous WAT is considered to protect against metabolic disease. Recent findings indicate that thermogenic genes, expressed in brown adipose tissue (...)
• 00:00
  Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes is a growing global public health challenge. Investigating quantitative traits, including fasting glucose, fasting insulin and HbA1c, that serve as early markers of type 2 diabetes progression may lead to a deeper understanding of the genetic aetiology (...)
• 00:00
  Differences in the prevalence of erectile dysfunction between novel subgroups of recent-onset diabetes Diabetologia
  Abstract Aims/hypothesis In men with diabetes, the prevalence of erectile dysfunction increases with advanced age and longer diabetes duration and is substantially higher in men with type 2 diabetes than those with type 1 diabetes. This study aimed to evaluate the prevalence of erectile (...)
• 00:00
  Artificial intelligence utilising corneal confocal microscopy for the diagnosis of peripheral neuropathy in diabetes mellitus and prediabetes Diabetologia
  Abstract Aims/hypothesis We aimed to develop an artificial intelligence (AI)-based deep learning algorithm (DLA) applying attribution methods without image segmentation to corneal confocal microscopy images and to accurately classify peripheral neuropathy (or lack of). Methods The AI-based (...)
• 00:00
  Longitudinal changes in glucose during pregnancy in women with gestational diabetes risk factors Diabetologia
  Abstract Aims/hypothesis Despite recommendations to screen women with diabetes risk factors for hyperglycaemia in the first trimester, criteria for normal glucose values in early pregnancy have not been firmly established. We aimed to compare glucose levels in early pregnancy with those later (...)
• 00:00
  Higher baseline inflammatory marker levels predict greater cognitive decline in older people with type 2 diabetes: year 10 follow-up of the Edinburgh Type 2 Diabetes Study Diabetologia
  Abstract Aims/hypothesis We aimed to determine the longitudinal association of circulating markers of systemic inflammation with subsequent long-term cognitive change in older people with type 2 diabetes. Methods The Edinburgh Type 2 Diabetes Study is a prospective cohort study of 1066 adults (...)
• 00:00
  Advanced liver fibrosis measured by transient elastography predicts chronic kidney disease development in individuals with non-alcoholic fatty liver disease Diabetologia
  Abstract Aims/hypothesis Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are progressive chronic conditions that share important cardiometabolic risk factors and pathogenic mechanisms. We investigated the association between liver fibrosis measured by transient (...)
• 00:00
  The insulin hypersecretion hypothesis: cause or effect? Reply to Polychronakos C [letter] Diabetologia
• 00:00
  The insulin hypersecretion hypothesis: cause or effect? Diabetologia
• 00:00
  Prevalence of type 2 diabetes in psychiatric disorders: an umbrella review with meta-analysis of 245 observational studies from 32 systematic reviews Diabetologia
  Abstract Aims/hypothesis Estimates of the global prevalence of type 2 diabetes vary between 6% and 9%. The prevalence of type 2 diabetes has been investigated in psychiatric populations but a critical appraisal of the existing evidence is lacking, and an overview is needed. This umbrella (...)
• 00:00
  The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice Diabetologia
  Abstract Aims/hypothesis Second-generation antipsychotic (SGA) drugs have been associated with the development of type 2 diabetes and the metabolic syndrome in patients with schizophrenia. In this study, we aimed to investigate the effects of two different SGA drugs, olanzapine and (...)
• 00:00
  MicroRNA-193b impairs muscle growth in mouse models of type 2 diabetes by targeting the PDK1/Akt signalling pathway Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes is associated with a reduction in skeletal muscle mass; however, how the progression of sarcopenia is induced and regulated remains largely unknown. We aimed to find out whether a specific microRNA (miR) may contribute to skeletal muscle atrophy in type (...)
• 00:00
  Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet Diabetologia
  Abstract Aims/hypothesis Despite a similar fat storing function, visceral (intra-abdominal) white adipose tissue (WAT) is detrimental, whereas subcutaneous WAT is considered to protect against metabolic disease. Recent findings indicate that thermogenic genes, expressed in brown adipose tissue (...)
• 00:00
  Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes is a growing global public health challenge. Investigating quantitative traits, including fasting glucose, fasting insulin and HbA1c, that serve as early markers of type 2 diabetes progression may lead to a deeper understanding of the genetic aetiology (...)
• 00:00
  Differences in the prevalence of erectile dysfunction between novel subgroups of recent-onset diabetes Diabetologia
  Abstract Aims/hypothesis In men with diabetes, the prevalence of erectile dysfunction increases with advanced age and longer diabetes duration and is substantially higher in men with type 2 diabetes than those with type 1 diabetes. This study aimed to evaluate the prevalence of erectile (...)
• 00:00
  Artificial intelligence utilising corneal confocal microscopy for the diagnosis of peripheral neuropathy in diabetes mellitus and prediabetes Diabetologia
  Abstract Aims/hypothesis We aimed to develop an artificial intelligence (AI)-based deep learning algorithm (DLA) applying attribution methods without image segmentation to corneal confocal microscopy images and to accurately classify peripheral neuropathy (or lack of). Methods The AI-based (...)
• 00:00
  Longitudinal changes in glucose during pregnancy in women with gestational diabetes risk factors Diabetologia
  Abstract Aims/hypothesis Despite recommendations to screen women with diabetes risk factors for hyperglycaemia in the first trimester, criteria for normal glucose values in early pregnancy have not been firmly established. We aimed to compare glucose levels in early pregnancy with those later (...)
• 00:00
  Higher baseline inflammatory marker levels predict greater cognitive decline in older people with type 2 diabetes: year 10 follow-up of the Edinburgh Type 2 Diabetes Study Diabetologia
  Abstract Aims/hypothesis We aimed to determine the longitudinal association of circulating markers of systemic inflammation with subsequent long-term cognitive change in older people with type 2 diabetes. Methods The Edinburgh Type 2 Diabetes Study is a prospective cohort study of 1066 adults (...)
• 00:00
  Advanced liver fibrosis measured by transient elastography predicts chronic kidney disease development in individuals with non-alcoholic fatty liver disease Diabetologia
  Abstract Aims/hypothesis Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are progressive chronic conditions that share important cardiometabolic risk factors and pathogenic mechanisms. We investigated the association between liver fibrosis measured by transient (...)

25 February

Diabetologia http://link.springer.com/

• 00:00
  Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice Diabetologia
  Abstract Aims/hypothesis Diabetic cardiomyopathy (DCM) is a serious and under-recognised complication of diabetes. The first sign is diastolic dysfunction, which progresses to heart failure. The pathophysiology of DCM is incompletely understood but microcirculatory changes are important. (...)

23 February

Diabetologia http://link.springer.com/

• 00:00
  Familial aggregation and shared genetic loading for major psychiatric disorders and type 2 diabetes Diabetologia
  Abstract Aims/hypothesis Psychiatric disorders, such as schizophrenia (SCZ), major depressive disorder (MDD) and bipolar disorder (BPD), are highly comorbid with type 2 diabetes. However, the mechanisms underlying such comorbidity are understudied. This study explored the familial aggregation (...)

22 February

Diabetologia http://link.springer.com/

• 00:00
  Prediabetes blunts DPP4 genetic control of postprandial glycaemia and insulin secretion Diabetologia
  Abstract Aims/hypothesis Imbalances in glucose metabolism are hallmarks of clinically silent prediabetes (defined as impaired fasting glucose and/or impaired glucose tolerance) representing dysmetabolism trajectories leading to type 2 diabetes. CD26/dipeptidyl peptidase 4 (DPP4) is a (...)

19 February

Diabetologia http://link.springer.com/

• 00:00
  Up front Diabetologia
• 00:00
  Urinary albumin/creatinine ratio tertiles predict risk of diabetic retinopathy progression: a natural history study from the Adolescent Cardio-Renal Intervention Trial (AdDIT) observational cohort Diabetologia
  Abstract Aims/hypothesis We hypothesised that adolescents with type 1 diabetes with a urinary albumin/creatinine ratio (ACR) in the upper tertile of the normal range (high ACR) are at greater risk of three-step diabetic retinopathy progression (3DR) independent of glycaemic control. Methods (...)

15 February

Diabetologia http://link.springer.com/

• 00:00
  Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes is a complex metabolic disease with increasing prevalence worldwide. Improving the prediction of incident type 2 diabetes using epigenetic markers could help tailor prevention efforts to those at the highest risk. The aim of this study was to identify (...)

12 February

Diabetologia http://link.springer.com/

• 00:00
  Lifestyle interventions in pregnancy targeting GDM prevention: looking ahead to precision medicine Diabetologia
  Abstract Gestational diabetes mellitus (GDM) is the most prevalent pregnancy-related endocrinopathy, affecting up to 25% of pregnancies worldwide. Pregnant individuals who develop GDM have an increased risk of complications during pregnancy and birth, as well as future development of type 2 (...)

11 February

Diabetologia http://link.springer.com/

• 00:00
  Lipids, hyperreflective crystalline deposits and diabetic retinopathy: potential systemic and retinal-specific effect of lipid-lowering therapies Diabetologia
  Abstract The metabolically active retina obtains essential lipids by endogenous biosynthesis and from the systemic circulation. Clinical studies provide limited and sometimes conflicting evidence as to the relationships between circulating lipid levels and the development and progression of (...)

10 February

Diabetologia http://link.springer.com/

• 00:00
  Early DNA methylation changes in children developing beta cell autoimmunity at a young age Diabetologia
  Abstract Aims/hypothesis Type 1 diabetes is a chronic autoimmune disease of complex aetiology, including a potential role for epigenetic regulation. Previous epigenomic studies focused mainly on clinically diagnosed individuals. The aim of the study was to assess early DNA methylation changes (...)

9 February

Diabetologia http://link.springer.com/

• 00:00
  Effectiveness of continuous glucose monitoring in maintaining glycaemic control among people with type 1 diabetes mellitus: a systematic review of randomised controlled trials and meta-analysis Diabetologia
  Abstract Aims/hypothesis The aim of this work was to assess the effectiveness of continuous glucose monitoring (CGM) vs self-monitoring of blood glucose (SMBG) in maintaining glycaemic control among people with type 1 diabetes mellitus. Methods Cochrane Library, PubMed, Embase, CINAHL, (...)
• 00:00
  Understanding the pathogenesis of lean non-autoimmune diabetes in an African population with newly diagnosed diabetes Diabetologia
  Abstract Aims/hypothesis Apparent type 2 diabetes is increasingly reported in lean adult individuals in sub-Saharan Africa. However, studies undertaking robust clinical and metabolic characterisation of lean individuals with new-onset type 2 diabetes are limited in this population. This (...)

8 February

Diabetologia http://link.springer.com/

• 00:00
  One size does not fit all: an historian’s perspective on precision diabetes medicine Diabetologia
  Abstract This article offers an historical approach to exploring precision medicine’s potential for reducing health disparities in diabetes. It examines case studies from the twentieth-century USA, from early twentieth-century beliefs that Jews were most at risk of developing diabetes to claims (...)

7 February

Diabetologia http://link.springer.com/

• 00:00
  Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes and atherosclerotic CVD share many risk factors. This study aimed to systematically assess a broad range of continuous traits to separate their direct effects on coronary and peripheral artery disease from those mediated by type 2 diabetes. Methods Our (...)
• 00:00
  Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes and atherosclerotic CVD share many risk factors. This study aimed to systematically assess a broad range of continuous traits to separate their direct effects on coronary and peripheral artery disease from those mediated by type 2 diabetes. Methods Our (...)

5 February

Diabetologia http://link.springer.com/

• 00:00
  Proinflammatory cytokines induce rapid, NO-independent apoptosis, expression of chemotactic mediators and interleukin-32 secretion in human pluripotent stem cell-derived beta cells Diabetologia
  Abstract Aims/hypothesis The aim of this study was to examine the effects of proinflammatory cytokines on cells of different developmental stages during the generation of stem cell-derived beta cells (SC-beta cells) from human pluripotent stem cells (hPSCs). We wanted to find out to what (...)
• 00:00
  Proinflammatory cytokines induce rapid, NO-independent apoptosis, expression of chemotactic mediators and interleukin-32 secretion in human pluripotent stem cell-derived beta cells Diabetologia
  Abstract Aims/hypothesis The aim of this study was to examine the effects of proinflammatory cytokines on cells of different developmental stages during the generation of stem cell-derived beta cells (SC-beta cells) from human pluripotent stem cells (hPSCs). We wanted to find out to what (...)

4 February

Diabetologia http://link.springer.com/

• 00:00
  Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation—relevance for (pre)diabetes: The Maastricht Study Diabetologia
  Abstract Aims/hypothesis Biomarkers of endothelial dysfunction and low-grade inflammation are important in the pathogenesis of CVD and can potentially be modified by physical activity and sedentary behaviour. Effects of physical activity on biomarkers of endothelial dysfunction may be (...)
• 00:00
  Sedentary behaviour and physical activity are associated with biomarkers of endothelial dysfunction and low-grade inflammation—relevance for (pre)diabetes: The Maastricht Study Diabetologia
  Abstract Aims/hypothesis Biomarkers of endothelial dysfunction and low-grade inflammation are important in the pathogenesis of CVD and can potentially be modified by physical activity and sedentary behaviour. Effects of physical activity on biomarkers of endothelial dysfunction may be (...)

2 February

Diabetologia http://link.springer.com/

• 00:00
  The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day Diabetologia
  Abstract Aims/hypothesis In our modern society, artificial light is available around the clock and most people expose themselves to electrical light and light-emissive screens during the dark period of the natural light/dark cycle. Such suboptimal lighting conditions have been associated with (...)
• 00:00
  The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day Diabetologia
  Abstract Aims/hypothesis In our modern society, artificial light is available around the clock and most people expose themselves to electrical light and light-emissive screens during the dark period of the natural light/dark cycle. Such suboptimal lighting conditions have been associated with (...)

1 February

Diabetologia http://link.springer.com/

• 00:00
  Breastfeeding and circulating immunological markers during the first 3 years of life: the DIABIMMUNE study Diabetologia
  Abstract Aims/hypothesis Our aim was to study the association between duration of breastfeeding and circulating immunological markers during the first 3 years of life in children with HLA-conferred susceptibility to type 1 diabetes. Methods We performed a longitudinal analysis of 38 (...)
• 00:00
  Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle Diabetologia
  Abstract Aims/hypothesis Energy-dense nutrition generally induces insulin resistance, but dietary composition may differently affect glucose metabolism. This study investigated initial effects of monounsaturated vs saturated lipid meals on basal and insulin-stimulated myocellular glucose (...)
• 00:00
  Impact of insufficient sleep on dysregulated blood glucose control under standardised meal conditions Diabetologia
  Abstract Aims/hypothesis Sleep, diet and exercise are fundamental to metabolic homeostasis. In this secondary analysis of a repeated measures, nutritional intervention study, we tested whether an individual’s sleep quality, duration and timing impact glycaemic response to a breakfast meal the (...)
• 00:00
  Fatty acid-binding protein 4: a key regulator of ketoacidosis in new-onset type 1 diabetes Diabetologia
  Abstract Aims/hypothesis Fatty acid-binding protein 4 (FABP4) is an adipokine with a key regulatory role in glucose and lipid metabolism. We prospectively evaluated the role of FABP4 in the pathophysiology of diabetic ketoacidosis (DKA) in new-onset type 1 diabetes. Methods Clinical and (...)
• 00:00
  Relative leucocyte telomere length is associated with incident end-stage kidney disease and rapid decline of kidney function in type 2 diabetes: analysis from the Hong Kong Diabetes Register Diabetologia
  Abstract Aims/hypothesis Few large-scale prospective studies have investigated associations between relative leucocyte telomere length (rLTL) and kidney dysfunction in individuals with type 2 diabetes. We examined relationships between rLTL and incident end-stage kidney disease (ESKD) and the (...)
• 00:00
  Environmental risk factors of type 2 diabetes—an exposome approach Diabetologia
  Abstract Type 2 diabetes is one of the major chronic diseases accounting for a substantial proportion of disease burden in Western countries. The majority of the burden of type 2 diabetes is attributed to environmental risks and modifiable risk factors such as lifestyle. The environment we (...)
• 00:00
  Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies Diabetologia
  Abstract Aims/hypothesis The term prediabetes is used for individuals who have impaired glucose metabolism whose glucose or HbA1c levels are not yet high enough to be diagnosed as diabetes. Prediabetes may already be associated with an increased risk of chronic ‘diabetes-related’ complications. (...)
• 00:00
  Lipoprotein particle sizes and incident type 2 diabetes: the PREVEND cohort study Diabetologia
• 00:00
  Up front Diabetologia
• 00:00
  A PSAD Group response to the consensus report on the definition and interpretation of remission in type 2 diabetes: a psychosocial perspective is needed Diabetologia
• 00:00
  Systematic genetic testing for recessively inherited monogenic diabetes: a cross-sectional study in paediatric diabetes clinics Diabetologia
  Abstract Aims/hypothesis Current clinical guidelines for childhood-onset monogenic diabetes outside infancy are mainly focused on identifying and testing for dominantly inherited, predominantly MODY genes. There are no systematic studies of the recessively inherited causes of monogenic (...)
• 00:00
  Individualised screening of diabetic foot: creation of a prediction model based on penalised regression and assessment of theoretical efficacy Diabetologia
  Abstract Aims/hypothesis A large proportion of people with diabetes do not receive proper foot screening due to insufficiencies in healthcare systems. Introducing an effective risk prediction model into the screening protocol would potentially reduce the required screening frequency for those (...)
• 00:00
  Associations of plasma glycerophospholipid profile with modifiable lifestyles and incident diabetes in middle-aged and older Chinese Diabetologia
  Abstract Aims/hypothesis Glycerophospholipid (GPL) perturbance was linked to the pathogenesis of diabetes in animal studies but prospective studies in humans are rare, particularly in Asians. We aimed to investigate the associations between plasma GPLs and incident diabetes and to explore (...)
• 00:00
  Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes Diabetologia
  Abstract Aims/hypothesis Slow progressors to type 1 diabetes are individuals positive for multiple pancreatic islet autoantibodies who have remained diabetes-free for at least 10 years; regulation of the autoimmune response is understudied in this group. Here, we profile CD4+ regulatory T (...)
• 00:00
  Use of electronic patient data overview with alerts in primary care increases prescribing of lipid-lowering medications in patients with type 2 diabetes Diabetologia
  Abstract Aims/hypothesis We aimed to assess whether general practices (GPs) using an electronic disease management program (DMP) with population overviews, including alerts when patients failed to receive guideline-recommended prescription medications, increased prescriptions of lipid-lowering (...)
• 00:00
  Upregulation of HLA class II in pancreatic beta cells from organ donors with type 1 diabetes Diabetologia
  Abstract Aims/hypothesis We aimed to characterise and quantify the expression of HLA class II (HLA-II) in human pancreatic tissue sections and to analyse its induction in human islets. Methods We immunostained human pancreatic tissue sections from non-diabetic (n = 5), autoantibody positive (...)
• 00:00
  Lipoprotein particle sizes and incident type 2 diabetes: the PREVEND cohort study Diabetologia
• 00:00
  Up front Diabetologia
• 00:00
  A PSAD Group response to the consensus report on the definition and interpretation of remission in type 2 diabetes: a psychosocial perspective is needed Diabetologia
• 00:00
  Systematic genetic testing for recessively inherited monogenic diabetes: a cross-sectional study in paediatric diabetes clinics Diabetologia
  Abstract Aims/hypothesis Current clinical guidelines for childhood-onset monogenic diabetes outside infancy are mainly focused on identifying and testing for dominantly inherited, predominantly MODY genes. There are no systematic studies of the recessively inherited causes of monogenic (...)
• 00:00
  Individualised screening of diabetic foot: creation of a prediction model based on penalised regression and assessment of theoretical efficacy Diabetologia
  Abstract Aims/hypothesis A large proportion of people with diabetes do not receive proper foot screening due to insufficiencies in healthcare systems. Introducing an effective risk prediction model into the screening protocol would potentially reduce the required screening frequency for those (...)
• 00:00
  Associations of plasma glycerophospholipid profile with modifiable lifestyles and incident diabetes in middle-aged and older Chinese Diabetologia
  Abstract Aims/hypothesis Glycerophospholipid (GPL) perturbance was linked to the pathogenesis of diabetes in animal studies but prospective studies in humans are rare, particularly in Asians. We aimed to investigate the associations between plasma GPLs and incident diabetes and to explore (...)
• 00:00
  Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes Diabetologia
  Abstract Aims/hypothesis Slow progressors to type 1 diabetes are individuals positive for multiple pancreatic islet autoantibodies who have remained diabetes-free for at least 10 years; regulation of the autoimmune response is understudied in this group. Here, we profile CD4+ regulatory T (...)
• 00:00
  Use of electronic patient data overview with alerts in primary care increases prescribing of lipid-lowering medications in patients with type 2 diabetes Diabetologia
  Abstract Aims/hypothesis We aimed to assess whether general practices (GPs) using an electronic disease management program (DMP) with population overviews, including alerts when patients failed to receive guideline-recommended prescription medications, increased prescriptions of lipid-lowering (...)
• 00:00
  Upregulation of HLA class II in pancreatic beta cells from organ donors with type 1 diabetes Diabetologia
  Abstract Aims/hypothesis We aimed to characterise and quantify the expression of HLA class II (HLA-II) in human pancreatic tissue sections and to analyse its induction in human islets. Methods We immunostained human pancreatic tissue sections from non-diabetic (n = 5), autoantibody positive (...)
• 00:00
  Breastfeeding and circulating immunological markers during the first 3 years of life: the DIABIMMUNE study Diabetologia
  Abstract Aims/hypothesis Our aim was to study the association between duration of breastfeeding and circulating immunological markers during the first 3 years of life in children with HLA-conferred susceptibility to type 1 diabetes. Methods We performed a longitudinal analysis of 38 (...)
• 00:00
  Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle Diabetologia
  Abstract Aims/hypothesis Energy-dense nutrition generally induces insulin resistance, but dietary composition may differently affect glucose metabolism. This study investigated initial effects of monounsaturated vs saturated lipid meals on basal and insulin-stimulated myocellular glucose (...)
• 00:00
  Impact of insufficient sleep on dysregulated blood glucose control under standardised meal conditions Diabetologia
  Abstract Aims/hypothesis Sleep, diet and exercise are fundamental to metabolic homeostasis. In this secondary analysis of a repeated measures, nutritional intervention study, we tested whether an individual’s sleep quality, duration and timing impact glycaemic response to a breakfast meal the (...)
• 00:00
  Fatty acid-binding protein 4: a key regulator of ketoacidosis in new-onset type 1 diabetes Diabetologia
  Abstract Aims/hypothesis Fatty acid-binding protein 4 (FABP4) is an adipokine with a key regulatory role in glucose and lipid metabolism. We prospectively evaluated the role of FABP4 in the pathophysiology of diabetic ketoacidosis (DKA) in new-onset type 1 diabetes. Methods Clinical and (...)
• 00:00
  Relative leucocyte telomere length is associated with incident end-stage kidney disease and rapid decline of kidney function in type 2 diabetes: analysis from the Hong Kong Diabetes Register Diabetologia
  Abstract Aims/hypothesis Few large-scale prospective studies have investigated associations between relative leucocyte telomere length (rLTL) and kidney dysfunction in individuals with type 2 diabetes. We examined relationships between rLTL and incident end-stage kidney disease (ESKD) and the (...)
• 00:00
  Environmental risk factors of type 2 diabetes—an exposome approach Diabetologia
  Abstract Type 2 diabetes is one of the major chronic diseases accounting for a substantial proportion of disease burden in Western countries. The majority of the burden of type 2 diabetes is attributed to environmental risks and modifiable risk factors such as lifestyle. The environment we (...)
• 00:00
  Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies Diabetologia
  Abstract Aims/hypothesis The term prediabetes is used for individuals who have impaired glucose metabolism whose glucose or HbA1c levels are not yet high enough to be diagnosed as diabetes. Prediabetes may already be associated with an increased risk of chronic ‘diabetes-related’ complications. (...)

28 January

Diabetologia http://link.springer.com/

• 00:00
  Adiponectin deficiency induces hepatic steatosis during pregnancy and gestational diabetes in mice Diabetologia
  Abstract Aims/hypothesis Obesity and hepatic steatosis are risk factors for gestational diabetes mellitus (GDM), a common complication of pregnancy. Adiponectin is a fat-derived hormone that improves hepatic steatosis and insulin sensitivity. Low levels of circulating adiponectin are (...)

26 January

Diabetologia http://link.springer.com/

• 00:00
  Using genetics to assess the association of commonly used antihypertensive drugs with diabetes, glycaemic traits and lipids: a trans-ancestry Mendelian randomisation study Diabetologia
  Abstract Aims/hypothesis Diabetes and hyperlipidaemia are common comorbidities in people with hypertension. Despite similar protective effects on CVD, different classes of antihypertensive drugs have different effects on CVD risk factors, including diabetes, glucose metabolism and lipids. (...)
• 00:00
  Up Front Diabetologia

19 January

Diabetologia http://link.springer.com/

• 00:00
  Effects of progressive resistance training in individuals with type 2 diabetic polyneuropathy: a randomised assessor-blinded controlled trial Diabetologia
  Abstract Aims/hypothesis The aim of this study was to evaluate the effects of progressive resistance training (PRT) on muscle strength, intraepidermal nerve fibre density (IENFD) and motor function in individuals with type 2 diabetic polyneuropathy (DPN) and to compare potential adaptations to (...)
• 00:00
  Effects of progressive resistance training in individuals with type 2 diabetic polyneuropathy: a randomised assessor-blinded controlled trial Diabetologia
  Abstract Aims/hypothesis The aim of this study was to evaluate the effects of progressive resistance training (PRT) on muscle strength, intraepidermal nerve fibre density (IENFD) and motor function in individuals with type 2 diabetic polyneuropathy (DPN) and to compare potential adaptations to (...)

18 January

Diabetologia http://link.springer.com/

• 00:00
  Characterising the age-dependent effects of risk factors on type 1 diabetes progression Diabetologia
  Abstract Aims/hypothesis Age is known to be one of the most important stratifiers of disease progression in type 1 diabetes. However, what drives the difference in rate of progression between adults and children is poorly understood. Evidence suggests that many type 1 diabetes disease (...)
• 00:00
  Circulating metabolite profile in young adulthood identifies long-term diabetes susceptibility: the Coronary Artery Risk Development in Young Adults (CARDIA) study Diabetologia
  Abstract Aims/hypothesis The aim of this work was to define metabolic correlates and pathways of diabetes pathogenesis in young adults during a subclinical latent phase of diabetes development. Methods We studied 2083 young adults of Black and White ethnicity in the prospective observational (...)
• 00:00
  Characterising the age-dependent effects of risk factors on type 1 diabetes progression Diabetologia
  Abstract Aims/hypothesis Age is known to be one of the most important stratifiers of disease progression in type 1 diabetes. However, what drives the difference in rate of progression between adults and children is poorly understood. Evidence suggests that many type 1 diabetes disease (...)
• 00:00
  Circulating metabolite profile in young adulthood identifies long-term diabetes susceptibility: the Coronary Artery Risk Development in Young Adults (CARDIA) study Diabetologia
  Abstract Aims/hypothesis The aim of this work was to define metabolic correlates and pathways of diabetes pathogenesis in young adults during a subclinical latent phase of diabetes development. Methods We studied 2083 young adults of Black and White ethnicity in the prospective observational (...)

15 January

Diabetologia http://link.springer.com/

• 00:00
  Cardiovascular risk prediction in type 2 diabetes: a comparison of 22 risk scores in primary care settings Diabetologia
  Abstract Aims/hypothesis We aimed to compare the performance of risk prediction scores for CVD (i.e., coronary heart disease and stroke), and a broader definition of CVD including atrial fibrillation and heart failure (CVD+), in individuals with type 2 diabetes. Methods Scores were identified (...)
• 00:00
  Cardiovascular risk prediction in type 2 diabetes: a comparison of 22 risk scores in primary care settings Diabetologia
  Abstract Aims/hypothesis We aimed to compare the performance of risk prediction scores for CVD (i.e., coronary heart disease and stroke), and a broader definition of CVD including atrial fibrillation and heart failure (CVD+), in individuals with type 2 diabetes. Methods Scores were identified (...)

12 January

Diabetologia http://link.springer.com/

• 00:00
  Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells Diabetologia
  Abstract Aims/hypothesis Chronic exposure of pancreatic beta cells to high glucose and fatty acids has been proposed to induce glucolipotoxicity. However, contradictory results suggest adaptations of the beta cells, which might be instrumental for partial preservation of the secretory (...)
• 00:00
  Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells Diabetologia
  Abstract Aims/hypothesis Chronic exposure of pancreatic beta cells to high glucose and fatty acids has been proposed to induce glucolipotoxicity. However, contradictory results suggest adaptations of the beta cells, which might be instrumental for partial preservation of the secretory (...)

7 January

Diabetologia http://link.springer.com/

• 00:00
  Metabolic, structural and biochemical changes in diabetes and the development of heart failure Diabetologia
  Abstract Diabetes contributes to the development of heart failure through various metabolic, structural and biochemical changes. The presence of diabetes increases the risk for the development of cardiovascular disease (CVD), and since the introduction of cardiovascular outcome trials to test (...)
• 00:00
  Dietary carbohydrate restriction augments weight loss-induced improvements in glycaemic control and liver fat in individuals with type 2 diabetes: a randomised controlled trial Diabetologia
  Abstract Aims/hypothesis Lifestyle modification and weight loss are cornerstones of type 2 diabetes management. However, carbohydrate restriction may have weight-independent beneficial effects on glycaemic control. This has been difficult to demonstrate because low-carbohydrate diets readily (...)
• 00:00
  Metabolic, structural and biochemical changes in diabetes and the development of heart failure Diabetologia
  Abstract Diabetes contributes to the development of heart failure through various metabolic, structural and biochemical changes. The presence of diabetes increases the risk for the development of cardiovascular disease (CVD), and since the introduction of cardiovascular outcome trials to test (...)
• 00:00
  Dietary carbohydrate restriction augments weight loss-induced improvements in glycaemic control and liver fat in individuals with type 2 diabetes: a randomised controlled trial Diabetologia
  Abstract Aims/hypothesis Lifestyle modification and weight loss are cornerstones of type 2 diabetes management. However, carbohydrate restriction may have weight-independent beneficial effects on glycaemic control. This has been difficult to demonstrate because low-carbohydrate diets readily (...)
• 00:00
  Do gene–environment interactions have implications for the precision prevention of type 2 diabetes? Diabetologia
  Abstract The past decades have seen a rapid global rise in the incidence of type 2 diabetes. This surge has been driven by diabetogenic environmental changes that may act together with a genetic predisposition to type 2 diabetes. It is possible that there is a synergistic gene–environment (...)

4 January

Diabetologia http://link.springer.com/

• 00:00
  A novel diabetes typology: towards precision diabetology from pathogenesis to treatment Diabetologia
  Abstract The current classification of diabetes, based on hyperglycaemia, islet-directed antibodies and some insufficiently defined clinical features, does not reflect differences in aetiological mechanisms and in the clinical course of people with diabetes. This review discusses evidence from (...)

1 January

Diabetologia http://link.springer.com/

• 00:00
  Correction to: Neuron-specific biomarkers predict hypo- and hyperalgesia in individuals with diabetic peripheral neuropathy Diabetologia
• 00:00
  Correction to: DR15-DQ6 remains dominantly protective against type 1 diabetes throughout the first five decades of life Diabetologia
• 00:00
  Correction to: Flash glucose monitoring and automated bolus calculation in type 1 diabetes treated with multiple daily insulin injections: a 26 week randomised, controlled, multicentre trial Diabetologia
• 00:00
  Correction to: Subgroups of patients with young-onset type 2 diabetes in India reveal insulin deficiency as a major driver Diabetologia
• 00:00
  Predicting non-insulin-dependent state in patients with slowly progressive insulin-dependent (type 1) diabetes mellitus or latent autoimmune diabetes in adults Diabetologia
• 00:00
  Predicting non-insulin-dependent state in patients with slowly progressive insulin-dependent (type 1) diabetes mellitus or latent autoimmune diabetes in adults. Reply to Sugiyama K and Saisho Y [letter] Diabetologia
• 00:00
  IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes is characterised by islet amyloid and toxic oligomers of islet amyloid polypeptide (IAPP). We posed the questions, (1) does IAPP toxicity induce an islet response comparable to that in humans with type 2 diabetes, and if so, (2) what are the key (...)
• 00:00
  Type 2 diabetes risks and determinants in second-generation migrants and mixed ethnicity people of South Asian and African Caribbean descent in the UK Diabetologia
  Abstract Aims/hypothesis Excess risks of type 2 diabetes in UK South Asians (SA) and African Caribbeans (AC) compared with Europeans remain unexplained. We studied risks and determinants of type 2 diabetes in first- and second-generation (born in the UK) migrants, and in those of mixed (...)
• 00:00
  Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes confers a greater relative increase in CVD risk in women compared with men. We examined sex differences in intraorgan fat and hepatic VLDL1-triacylglycerol (VLDL1-TG) export before and after major dietary weight loss. Methods A group with type 2 (...)
• 00:00
  The association between gestational diabetes and stillbirth: a systematic review and meta-analysis Diabetologia
  Abstract Aims/hypothesis Controversy exists over whether gestational diabetes increases the risk of stillbirth. The aim of this review was to examine the association between gestational diabetes and stillbirth. Methods We performed searches of the published literature to May 2021. Study (...)
• 00:00
  Kidney outcomes and all-cause mortality in people with type 2 diabetes exhibiting non-albuminuric kidney insufficiency Diabetologia
  Abstract Aim/hypothesis It remains unclear whether people with diabetes exhibiting non-albuminuric kidney insufficiency have higher risk of kidney function decline and mortality compared with those exhibiting preserved kidney function without albuminuria. Furthermore, information regarding the (...)
• 00:00
  Subgroups of patients with young-onset type 2 diabetes in India reveal insulin deficiency as a major driver Diabetologia
  Abstract Aim/hypothesis Five subgroups were described in European diabetes patients using a data driven machine learning approach on commonly measured variables. We aimed to test the applicability of this phenotyping in Indian individuals with young-onset type 2 diabetes. Methods We applied (...)
• 00:00
  Validation of the classification for type 2 diabetes into five subgroups: a report from the ORIGIN trial Diabetologia
  Abstract Aims/hypothesis Data analyses from Swedish individuals with newly diagnosed diabetes have suggested that diabetes could be classified into five subtypes that differ with respect to the progression of dysglycaemia and the incidence of diabetes consequences. We assessed this (...)
• 00:00
  Diabetes status modifies the long-term effect of lipoprotein-associated phospholipase A2 on major coronary events Diabetologia
  Abstract Aims/hypothesis Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has an independent prognostic association with major coronary events (MCE). However, no study has investigated whether type 2 diabetes status modifies the effect of Lp-PLA2 activity or inhibition on the risk of (...)
• 00:00
  Association of birthweight and penetrance of diabetes in individuals with HNF4A-MODY: a cohort study Diabetologia
• 00:00
  Diets for weight management in adults with type 2 diabetes: an umbrella review of published meta-analyses and systematic review of trials of diets for diabetes remission Diabetologia
  Abstract Aims/hypothesis Weight reduction is fundamental for type 2 diabetes management and remission, but uncertainty exists over which diet type is best to achieve and maintain weight loss. We evaluated dietary approaches for weight loss, and remission, in people with type 2 diabetes to (...)
• 00:00
  Urinary metabolite profiling and risk of progression of diabetic nephropathy in 2670 individuals with type 1 diabetes Diabetologia
  Abstract Aims/hypothesis This prospective, observational study examines associations between 51 urinary metabolites and risk of progression of diabetic nephropathy in individuals with type 1 diabetes by employing an automated NMR metabolomics technique suitable for large-scale urine sample (...)
• 00:00
  Impaired postprandial skeletal muscle vascular responses to a mixed meal challenge in normoglycaemic people with a parent with type 2 diabetes Diabetologia
  Abstract Aims/hypothesis Microvascular blood flow (MBF) increases in skeletal muscle postprandially to aid in glucose delivery and uptake in muscle. This vascular action is impaired in individuals who are obese or have type 2 diabetes. Whether MBF is impaired in normoglycaemic people at risk (...)
• 00:00
  Correction to: Neuron-specific biomarkers predict hypo- and hyperalgesia in individuals with diabetic peripheral neuropathy Diabetologia
• 00:00
  Correction to: DR15-DQ6 remains dominantly protective against type 1 diabetes throughout the first five decades of life Diabetologia
• 00:00
  Correction to: Flash glucose monitoring and automated bolus calculation in type 1 diabetes treated with multiple daily insulin injections: a 26 week randomised, controlled, multicentre trial Diabetologia
• 00:00
  Correction to: Subgroups of patients with young-onset type 2 diabetes in India reveal insulin deficiency as a major driver Diabetologia
• 00:00
  Predicting non-insulin-dependent state in patients with slowly progressive insulin-dependent (type 1) diabetes mellitus or latent autoimmune diabetes in adults Diabetologia
• 00:00
  Predicting non-insulin-dependent state in patients with slowly progressive insulin-dependent (type 1) diabetes mellitus or latent autoimmune diabetes in adults. Reply to Sugiyama K and Saisho Y [letter] Diabetologia
• 00:00
  IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes is characterised by islet amyloid and toxic oligomers of islet amyloid polypeptide (IAPP). We posed the questions, (1) does IAPP toxicity induce an islet response comparable to that in humans with type 2 diabetes, and if so, (2) what are the key (...)
• 00:00
  Type 2 diabetes risks and determinants in second-generation migrants and mixed ethnicity people of South Asian and African Caribbean descent in the UK Diabetologia
  Abstract Aims/hypothesis Excess risks of type 2 diabetes in UK South Asians (SA) and African Caribbeans (AC) compared with Europeans remain unexplained. We studied risks and determinants of type 2 diabetes in first- and second-generation (born in the UK) migrants, and in those of mixed (...)
• 00:00
  Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes confers a greater relative increase in CVD risk in women compared with men. We examined sex differences in intraorgan fat and hepatic VLDL1-triacylglycerol (VLDL1-TG) export before and after major dietary weight loss. Methods A group with type 2 (...)
• 00:00
  The association between gestational diabetes and stillbirth: a systematic review and meta-analysis Diabetologia
  Abstract Aims/hypothesis Controversy exists over whether gestational diabetes increases the risk of stillbirth. The aim of this review was to examine the association between gestational diabetes and stillbirth. Methods We performed searches of the published literature to May 2021. Study (...)
• 00:00
  Kidney outcomes and all-cause mortality in people with type 2 diabetes exhibiting non-albuminuric kidney insufficiency Diabetologia
  Abstract Aim/hypothesis It remains unclear whether people with diabetes exhibiting non-albuminuric kidney insufficiency have higher risk of kidney function decline and mortality compared with those exhibiting preserved kidney function without albuminuria. Furthermore, information regarding the (...)
• 00:00
  Subgroups of patients with young-onset type 2 diabetes in India reveal insulin deficiency as a major driver Diabetologia
  Abstract Aim/hypothesis Five subgroups were described in European diabetes patients using a data driven machine learning approach on commonly measured variables. We aimed to test the applicability of this phenotyping in Indian individuals with young-onset type 2 diabetes. Methods We applied (...)
• 00:00
  Validation of the classification for type 2 diabetes into five subgroups: a report from the ORIGIN trial Diabetologia
  Abstract Aims/hypothesis Data analyses from Swedish individuals with newly diagnosed diabetes have suggested that diabetes could be classified into five subtypes that differ with respect to the progression of dysglycaemia and the incidence of diabetes consequences. We assessed this (...)
• 00:00
  Diabetes status modifies the long-term effect of lipoprotein-associated phospholipase A2 on major coronary events Diabetologia
  Abstract Aims/hypothesis Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has an independent prognostic association with major coronary events (MCE). However, no study has investigated whether type 2 diabetes status modifies the effect of Lp-PLA2 activity or inhibition on the risk of (...)
• 00:00
  Association of birthweight and penetrance of diabetes in individuals with HNF4A-MODY: a cohort study Diabetologia
• 00:00
  Diets for weight management in adults with type 2 diabetes: an umbrella review of published meta-analyses and systematic review of trials of diets for diabetes remission Diabetologia
  Abstract Aims/hypothesis Weight reduction is fundamental for type 2 diabetes management and remission, but uncertainty exists over which diet type is best to achieve and maintain weight loss. We evaluated dietary approaches for weight loss, and remission, in people with type 2 diabetes to (...)
• 00:00
  Urinary metabolite profiling and risk of progression of diabetic nephropathy in 2670 individuals with type 1 diabetes Diabetologia
  Abstract Aims/hypothesis This prospective, observational study examines associations between 51 urinary metabolites and risk of progression of diabetic nephropathy in individuals with type 1 diabetes by employing an automated NMR metabolomics technique suitable for large-scale urine sample (...)
• 00:00
  Impaired postprandial skeletal muscle vascular responses to a mixed meal challenge in normoglycaemic people with a parent with type 2 diabetes Diabetologia
  Abstract Aims/hypothesis Microvascular blood flow (MBF) increases in skeletal muscle postprandially to aid in glucose delivery and uptake in muscle. This vascular action is impaired in individuals who are obese or have type 2 diabetes. Whether MBF is impaired in normoglycaemic people at risk (...)

4 December

Diabetologia http://link.springer.com/

• 00:00
  Eva Maria Kohner, 23 February 1929–24 September 2021 Diabetologia
• 00:00
  Eva Maria Kohner, 23 February 1929–24 September 2021 Diabetologia

2 December

Diabetologia http://link.springer.com/

• 00:00
  Association between weight change and incidence of cardiovascular disease events and mortality among adults with type 2 diabetes: a systematic review of observational studies and behavioural intervention trials Diabetologia
  Abstract Aims/hypothesis Weight loss is often recommended in the treatment of type 2 diabetes. While evidence has shown that large weight loss may lead to diabetes remission and improvement in cardiovascular risk factors, long-term impacts are unclear. We performed a systematic review of (...)
• 00:00
  Association between weight change and incidence of cardiovascular disease events and mortality among adults with type 2 diabetes: a systematic review of observational studies and behavioural intervention trials Diabetologia
  Abstract Aims/hypothesis Weight loss is often recommended in the treatment of type 2 diabetes. While evidence has shown that large weight loss may lead to diabetes remission and improvement in cardiovascular risk factors, long-term impacts are unclear. We performed a systematic review of (...)

1 December

Diabetologia http://link.springer.com/

• 00:00
  Correction to: The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) Diabetologia
  Graphical abstract
• 00:00
  Up front Diabetologia
• 00:00
  Correction to: The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) Diabetologia
  Graphical abstract
• 00:00
  Up front Diabetologia
• 00:00
  Up front Diabetologia
• 00:00
  The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of M?ori and Pacific ancestry Diabetologia
  Abstract Aims/hypothesis The minor A allele of rs373863828 (CREBRF p.Arg457Gln) is associated with increased BMI, but reduced risk of type 2 and gestational diabetes in Polynesian (Pacific peoples and Aotearoa New Zealand M?ori) populations. This study investigates the effect of the A allele on (...)
• 00:00
  Neuron-specific biomarkers predict hypo- and hyperalgesia in individuals with diabetic peripheral neuropathy Diabetologia
  Abstract Aims/hypothesis The individual risk of progression of diabetic peripheral neuropathy is difficult to predict for each individual. Mutations in proteins that are responsible for the process of myelination are known to cause neurodegeneration and display alteration in experimental (...)
• 00:00
  The efficacy and safety of novel classes of glucose-lowering drugs for cardiovascular outcomes: a network meta-analysis of randomised clinical trials Diabetologia
  Abstract Aims/hypothesis Several cardiovascular outcome trials on sodium–glucose cotransporter 2 inhibitors (SGLT2i) have been released recently, including trials enrolling patients with congestive heart failure (CHF) and chronic kidney disease (CKD). Comparisons of the efficacy and safety of (...)
• 00:00
  Leveraging human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide signalling Diabetologia
  Abstract Aims/hypothesis The aim of this study was to leverage human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide (GIP) signalling. Methods Data were obtained from summary statistics of large-scale genome-wide association studies. We (...)
• 00:00
  Type 1 diabetes in 2017: global estimates of incident and prevalent cases in children and adults Diabetologia
  Abstract Aims/hypothesis Data on type 1 diabetes incidence and prevalence are limited, particularly for adults. This study aims to estimate global numbers of incident and prevalent cases of type 1 diabetes in 2017 for all age groups, by country and areas defined by income and region. Methods (...)
• 00:00
  Type 2 diabetes burden among migrants in Europe: unravelling the causal pathways Diabetologia
  Abstract European populations are ethnically and culturally diverse due to international migration. Evidence indicates large ethnic inequalities in the prevalence of type 2 diabetes. This review discusses the burden of type 2 diabetes and its related complications, and the potential (...)
• 00:00
  Risk factors and incidence over time for lower extremity amputations in people with type 1 diabetes: an observational cohort study of 46,088 patients from the Swedish National Diabetes Registry Diabetologia
  Abstract Aims/hypothesis The aim of this work was to study the incidence over time of lower extremity amputations and determine variables associated with increased risk of amputations in people with type 1 diabetes. Methods Individuals with type 1 diabetes registered in the Swedish National (...)
• 00:00
  Flash glucose monitoring and automated bolus calculation in type 1 diabetes treated with multiple daily insulin injections: a 26 week randomised, controlled, multicentre trial Diabetologia
  Abstract Aims/hypothesis We aimed to compare the effects of intermittently scanned continuous glucose monitoring (isCGM) and carbohydrate counting with automated bolus calculation (ABC) with usual care. Methods In a randomised, controlled, open-label trial carried out at five diabetes clinics (...)
• 00:00
  Rivaroxaban compared with low-dose aspirin in individuals with type 2 diabetes and high cardiovascular risk: a randomised trial to assess effects on endothelial function, platelet activation and vascular biomarkers Diabetologia
  Abstract Aims/hypothesis Individuals with type 2 diabetes mellitus and subclinical inflammation have stimulated coagulation, activated platelets and endothelial dysfunction. Recent studies with the direct factor Xa inhibitor rivaroxaban in combination with low-dose aspirin demonstrated a (...)
• 00:00
  The novel GCK variant p.Val455Leu associated with hyperinsulinism is susceptible to allosteric activation and is conducive to weight gain and the development of diabetes Diabetologia
  Abstract Aims/hypothesis The mammalian enzyme glucokinase (GK), expressed predominantly in liver and pancreas, plays an essential role in carbohydrate metabolism. Monogenic GK disorders emphasise the role of GK in determining the blood glucose set point. Methods A family with congenital (...)
• 00:00
  Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women Diabetologia
  Abstract Aims/hypothesis In our current society sedentary behaviour predominates in most people and is associated with the risk of developing type 2 diabetes. It has been suggested that replacing sitting time by standing and walking could be beneficial for individuals with type 2 diabetes but (...)
• 00:00
  Characterisation of Ppy-lineage cells clarifies the functional heterogeneity of pancreatic beta cells in mice Diabetologia
  Abstract Aims/hypothesis Pancreatic polypeptide (PP) cells, which secrete PP (encoded by the Ppy gene), are a minor population of pancreatic endocrine cells. Although it has been reported that the loss of beta cell identity might be associated with beta-to-PP cell-fate conversion, at present, (...)
• 00:00
  Risk for ketonaemia in type 1 diabetes pregnancies with sensor-augmented pump therapy with predictive low glucose suspend compared with low glucose suspend: a crossover RCT Diabetologia
  Abstract Aims To determine the frequency of ketonaemia in pregnant women with type 1 diabetes treated with a sensor-augmented pump (SAP) in predictive low glucose suspend (PLGS) mode compared with low glucose suspend (LGS) mode. Methods An open-label crossover pilot RCT in ten women with type (...)
• 00:00
  The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) Diabetologia
  Abstract The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) convened a writing group to develop a consensus statement on the management of type 1 diabetes in adults. The writing group has considered the rapid development of new treatments and (...)
• 00:00
  The importance of increasing population diversity in genetic studies of type 2 diabetes and related glycaemic traits Diabetologia
  Abstract Type 2 diabetes has a global prevalence, with epidemiological data suggesting that some populations have a higher risk of developing this disease. However, to date, most genetic studies of type 2 diabetes and related glycaemic traits have been performed in individuals of European (...)
• 00:00
  Immunoregulated insulitis and slow-progressing type 1 diabetes after duodenopancreatectomy Diabetologia
  Abstract Aims/hypothesis We report the case of a woman who underwent a partial pancreatectomy for a serous cystadenoma when aged 56 years. She had been diagnosed with diabetes 6 years before and had Hashimoto’s thyroiditis. Despite positive anti-GAD autoantibodies (GADA) and previous surgery, (...)
• 00:00
  Joint effects of educational attainment, type 2 diabetes and coexisting morbidity on disability pension: results from a longitudinal, nationwide, register-based study Diabetologia
  Abstract Aims/hypothesis High prevalence of coexisting morbidity in people with type 2 diabetes highlights the need to include interactions with education and comorbidity in the assessments of societal consequences of type 2 diabetes. The purpose of this study was to estimate the joint effects (...)
• 00:00
  Higher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile Diabetologia
  Abstract Aims/hypothesis Higher maternal BMI during pregnancy is associated with higher offspring birthweight, but it is not known whether this is solely the result of adverse metabolic consequences of higher maternal adiposity, such as maternal insulin resistance and fetal exposure to higher (...)
• 00:00
  Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring—the heart as a target for fetal programming in rats Diabetologia
  Abstract Aims/hypothesis The impact of diabetic pregnancy has been investigated extensively regarding offspring metabolism; however, little is known about the influence on the heart. We aimed to characterise the effects of a diabetic pregnancy on male adult offspring cardiac health after (...)
• 00:00
  Up front Diabetologia
• 00:00
  The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of M?ori and Pacific ancestry Diabetologia
  Abstract Aims/hypothesis The minor A allele of rs373863828 (CREBRF p.Arg457Gln) is associated with increased BMI, but reduced risk of type 2 and gestational diabetes in Polynesian (Pacific peoples and Aotearoa New Zealand M?ori) populations. This study investigates the effect of the A allele on (...)
• 00:00
  Neuron-specific biomarkers predict hypo- and hyperalgesia in individuals with diabetic peripheral neuropathy Diabetologia
  Abstract Aims/hypothesis The individual risk of progression of diabetic peripheral neuropathy is difficult to predict for each individual. Mutations in proteins that are responsible for the process of myelination are known to cause neurodegeneration and display alteration in experimental (...)
• 00:00
  The efficacy and safety of novel classes of glucose-lowering drugs for cardiovascular outcomes: a network meta-analysis of randomised clinical trials Diabetologia
  Abstract Aims/hypothesis Several cardiovascular outcome trials on sodium–glucose cotransporter 2 inhibitors (SGLT2i) have been released recently, including trials enrolling patients with congestive heart failure (CHF) and chronic kidney disease (CKD). Comparisons of the efficacy and safety of (...)
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  Leveraging human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide signalling Diabetologia
  Abstract Aims/hypothesis The aim of this study was to leverage human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide (GIP) signalling. Methods Data were obtained from summary statistics of large-scale genome-wide association studies. We (...)
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  Type 1 diabetes in 2017: global estimates of incident and prevalent cases in children and adults Diabetologia
  Abstract Aims/hypothesis Data on type 1 diabetes incidence and prevalence are limited, particularly for adults. This study aims to estimate global numbers of incident and prevalent cases of type 1 diabetes in 2017 for all age groups, by country and areas defined by income and region. Methods (...)
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  Type 2 diabetes burden among migrants in Europe: unravelling the causal pathways Diabetologia
  Abstract European populations are ethnically and culturally diverse due to international migration. Evidence indicates large ethnic inequalities in the prevalence of type 2 diabetes. This review discusses the burden of type 2 diabetes and its related complications, and the potential (...)
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  Risk factors and incidence over time for lower extremity amputations in people with type 1 diabetes: an observational cohort study of 46,088 patients from the Swedish National Diabetes Registry Diabetologia
  Abstract Aims/hypothesis The aim of this work was to study the incidence over time of lower extremity amputations and determine variables associated with increased risk of amputations in people with type 1 diabetes. Methods Individuals with type 1 diabetes registered in the Swedish National (...)
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  Flash glucose monitoring and automated bolus calculation in type 1 diabetes treated with multiple daily insulin injections: a 26 week randomised, controlled, multicentre trial Diabetologia
  Abstract Aims/hypothesis We aimed to compare the effects of intermittently scanned continuous glucose monitoring (isCGM) and carbohydrate counting with automated bolus calculation (ABC) with usual care. Methods In a randomised, controlled, open-label trial carried out at five diabetes clinics (...)
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  Rivaroxaban compared with low-dose aspirin in individuals with type 2 diabetes and high cardiovascular risk: a randomised trial to assess effects on endothelial function, platelet activation and vascular biomarkers Diabetologia
  Abstract Aims/hypothesis Individuals with type 2 diabetes mellitus and subclinical inflammation have stimulated coagulation, activated platelets and endothelial dysfunction. Recent studies with the direct factor Xa inhibitor rivaroxaban in combination with low-dose aspirin demonstrated a (...)
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  The novel GCK variant p.Val455Leu associated with hyperinsulinism is susceptible to allosteric activation and is conducive to weight gain and the development of diabetes Diabetologia
  Abstract Aims/hypothesis The mammalian enzyme glucokinase (GK), expressed predominantly in liver and pancreas, plays an essential role in carbohydrate metabolism. Monogenic GK disorders emphasise the role of GK in determining the blood glucose set point. Methods A family with congenital (...)
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  Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women Diabetologia
  Abstract Aims/hypothesis In our current society sedentary behaviour predominates in most people and is associated with the risk of developing type 2 diabetes. It has been suggested that replacing sitting time by standing and walking could be beneficial for individuals with type 2 diabetes but (...)
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  Characterisation of Ppy-lineage cells clarifies the functional heterogeneity of pancreatic beta cells in mice Diabetologia
  Abstract Aims/hypothesis Pancreatic polypeptide (PP) cells, which secrete PP (encoded by the Ppy gene), are a minor population of pancreatic endocrine cells. Although it has been reported that the loss of beta cell identity might be associated with beta-to-PP cell-fate conversion, at present, (...)
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  Risk for ketonaemia in type 1 diabetes pregnancies with sensor-augmented pump therapy with predictive low glucose suspend compared with low glucose suspend: a crossover RCT Diabetologia
  Abstract Aims To determine the frequency of ketonaemia in pregnant women with type 1 diabetes treated with a sensor-augmented pump (SAP) in predictive low glucose suspend (PLGS) mode compared with low glucose suspend (LGS) mode. Methods An open-label crossover pilot RCT in ten women with type (...)
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  The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) Diabetologia
  Abstract The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) convened a writing group to develop a consensus statement on the management of type 1 diabetes in adults. The writing group has considered the rapid development of new treatments and (...)
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  The importance of increasing population diversity in genetic studies of type 2 diabetes and related glycaemic traits Diabetologia
  Abstract Type 2 diabetes has a global prevalence, with epidemiological data suggesting that some populations have a higher risk of developing this disease. However, to date, most genetic studies of type 2 diabetes and related glycaemic traits have been performed in individuals of European (...)
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  Immunoregulated insulitis and slow-progressing type 1 diabetes after duodenopancreatectomy Diabetologia
  Abstract Aims/hypothesis We report the case of a woman who underwent a partial pancreatectomy for a serous cystadenoma when aged 56 years. She had been diagnosed with diabetes 6 years before and had Hashimoto’s thyroiditis. Despite positive anti-GAD autoantibodies (GADA) and previous surgery, (...)
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  Joint effects of educational attainment, type 2 diabetes and coexisting morbidity on disability pension: results from a longitudinal, nationwide, register-based study Diabetologia
  Abstract Aims/hypothesis High prevalence of coexisting morbidity in people with type 2 diabetes highlights the need to include interactions with education and comorbidity in the assessments of societal consequences of type 2 diabetes. The purpose of this study was to estimate the joint effects (...)
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  Higher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile Diabetologia
  Abstract Aims/hypothesis Higher maternal BMI during pregnancy is associated with higher offspring birthweight, but it is not known whether this is solely the result of adverse metabolic consequences of higher maternal adiposity, such as maternal insulin resistance and fetal exposure to higher (...)
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  Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring—the heart as a target for fetal programming in rats Diabetologia
  Abstract Aims/hypothesis The impact of diabetic pregnancy has been investigated extensively regarding offspring metabolism; however, little is known about the influence on the heart. We aimed to characterise the effects of a diabetic pregnancy on male adult offspring cardiac health after (...)