24 March

Diabetologia http://link.springer.com/

• 16:12
  Up Front Diabetologia
• 16:12
  Determination of autoantibodies in type 2 diabetes: one simple way to improve classification Diabetologia
  Abstract This letter aims to increase interest in better classification of type 2 diabetes. This can be done in a simple and cheap way via determination of autoantibodies. Autoantibody analysis can be used to detect the 7–12% of people with diabetes that is phenotypic of type 2 diabetes but is, (...)
• 16:12
  Determination of autoantibodies in type 2 diabetes: one simple way to improve classification. Reply by Lean et al to Ludvigsson J [letter] Diabetologia
• 16:12
  Determination of autoantibodies in type 2 diabetes: one simple way to improve classification. Reply by Laferrère to Ludvigsson J [letter] Diabetologia
• 16:12
  Skeletal muscle and intermuscular adipose tissue gene expression profiling identifies new biomarkers with prognostic significance for insulin resistance progression and intervention response Diabetologia
  Abstract Aims/hypothesis Although insulin resistance often leads to type 2 diabetes mellitus, its early stages are often unrecognised, thus reducing the probability of successful prevention and intervention. Moreover, treatment efficacy is affected by the genetics of the individual. We used (...)
• 16:12
  Congenital malformations among offspring of women with type 1 diabetes who use insulin pumps: a prospective cohort study Diabetologia
  Abstract Aims/hypothesis Continuous subcutaneous insulin infusion by insulin pump is often superior in improving glycaemic control compared with conventional multiple daily insulin injection (MDI). However, whether pump treatment leads to improved pregnancy outcomes in terms of congenital (...)
• 16:12
  Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges Diabetologia
  Abstract Diabetes and its complications cause a heavy disease burden globally. Identifying exposures, risk factors and molecular processes causally associated with the development of diabetes can provide important evidence bases for disease prevention and spur novel therapeutic strategies. (...)
• 16:12
  Islet Autoantibody Standardization Program: interlaboratory comparison of insulin autoantibody assay performance in 2018 and 2020 workshops Diabetologia
  Abstract Aims/hypothesis The Islet Autoantibody Standardization Program (IASP) aims to improve the performance of immunoassays measuring autoantibodies in type 1 diabetes and the concordance of results across laboratories. IASP organises international workshops distributing anonymised serum (...)
• 16:12
  Risk of kidney disease following a pregnancy complicated by diabetes: a longitudinal, population-based data-linkage study among Aboriginal women in the Northern Territory, Australia Diabetologia
  Abstract Aims/hypothesis The aim of this work was to investigate the risk of developing chronic kidney disease (CKD) or end-stage kidney disease (ESKD) following a pregnancy complicated by gestational diabetes mellitus (GDM) or pre-existing diabetes among Aboriginal women in the Northern (...)
• 16:12
  Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study Diabetologia
  Abstract Aims/hypothesis Obesity is a major risk factor for type 2 diabetes. However, body composition differs between women and men. In this study we investigate the association between diabetes status and body composition and whether this association is moderated by sex. Methods In a (...)
• 16:12
  Embracing complexity: making sense of diet, nutrition, obesity and type 2 diabetes Diabetologia
  Abstract Nutrition therapy has been emphasised for decades for people with type 2 diabetes, and the vital importance of diet and nutrition is now also recognised for type 2 diabetes prevention. However, the complexity of diet and mixed messages on what is unhealthy, healthy or optimal have led (...)
• 16:12
  Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice Diabetologia
  Abstract Aims/hypothesis Non-alcoholic fatty liver disease (NAFLD) associated with type 2 diabetes may more easily progress towards severe forms of non-alcoholic steatohepatitis (NASH) and cirrhosis. Although the Wnt effector transcription factor 7-like 2 (TCF7L2) is closely associated with (...)
• 16:12
  Separate and combined effects of semaglutide and empagliflozin on kidney oxygenation and perfusion in people with type 2 diabetes: a randomised trial Diabetologia
  Abstract Aims/hypothesis Glucagon-like peptide-1 receptor agonists (GLP-1ras) and sodium–glucose cotransporter 2 inhibitors (SGLT2is) have shown kidney-protective effects. Improved kidney oxygenation and haemodynamic changes are suggested mechanisms; however, human data are scarce. We therefore (...)
• 16:12
  Chaperonin counteracts diet-induced non-alcoholic fatty liver disease by aiding sirtuin 3 in the control of fatty acid oxidation Diabetologia
  Abstract Aims/hypothesis The mitochondrial chaperonin heat shock protein (HSP) 60 is indispensable in protein folding and the mitochondrial stress response; however, its role in nutrient metabolism remains uncertain. This study investigated the role of HSP60 in diet-induced non-alcoholic fatty (...)

23 March

Diabetologia http://link.springer.com/

• 18:00
  Embracing complexity: making sense of diet, nutrition, obesity and type 2 diabetes Diabetologia
  Abstract Nutrition therapy has been emphasised for decades for people with type 2 diabetes, and the vital importance of diet and nutrition is now also recognised for type 2 diabetes prevention. However, the complexity of diet and mixed messages on what is unhealthy, healthy or optimal have led (...)
• 18:00
  Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice Diabetologia
  Abstract Aims/hypothesis Non-alcoholic fatty liver disease (NAFLD) associated with type 2 diabetes may more easily progress towards severe forms of non-alcoholic steatohepatitis (NASH) and cirrhosis. Although the Wnt effector transcription factor 7-like 2 (TCF7L2) is closely associated with (...)
• 18:00
  Chaperonin counteracts diet-induced non-alcoholic fatty liver disease by aiding sirtuin 3 in the control of fatty acid oxidation Diabetologia
  Abstract Aims/hypothesis The mitochondrial chaperonin heat shock protein (HSP) 60 is indispensable in protein folding and the mitochondrial stress response; however, its role in nutrient metabolism remains uncertain. This study investigated the role of HSP60 in diet-induced non-alcoholic fatty (...)

21 March

Diabetologia http://link.springer.com/

• 00:00
  Racial difference in the association between non-alcoholic fatty liver disease and incident type 2 diabetes: findings from the CARDIA study Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) are prevalent diseases of metabolic origin. We examined the association between NAFLD and the development of type 2 diabetes among non-Asian adults, and whether the association differs by race. Methods We (...)
• 00:00
  Racial difference in the association between non-alcoholic fatty liver disease and incident type 2 diabetes: findings from the CARDIA study Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) are prevalent diseases of metabolic origin. We examined the association between NAFLD and the development of type 2 diabetes among non-Asian adults, and whether the association differs by race. Methods We (...)

18 March

Diabetologia http://link.springer.com/

• 00:00
  Long-term cost-effectiveness of implementing a lifestyle intervention during pregnancy to reduce the incidence of gestational diabetes and type 2 diabetes Diabetologia
  Abstract Aims/hypothesis The aim of this study was to determine the long-term cost-effectiveness and return on investment of implementing a structured lifestyle intervention to reduce excessive gestational weight gain and associated incidence of gestational diabetes mellitus (GDM) and type 2 (...)
• 00:00
  Long-term cost-effectiveness of implementing a lifestyle intervention during pregnancy to reduce the incidence of gestational diabetes and type 2 diabetes Diabetologia
  Abstract Aims/hypothesis The aim of this study was to determine the long-term cost-effectiveness and return on investment of implementing a structured lifestyle intervention to reduce excessive gestational weight gain and associated incidence of gestational diabetes mellitus (GDM) and type 2 (...)

17 March

Diabetologia http://link.springer.com/

• 00:00
  Significant impact of time-of-day variation on metformin pharmacokinetics Diabetologia
  Abstract Aims/hypothesis The objective was to investigate if metformin pharmacokinetics is modulated by time-of-day in humans using empirical and mechanistic pharmacokinetic modelling techniques on a large clinical dataset. This study also aimed to generate and test hypotheses on the (...)
• 00:00
  Significant impact of time-of-day variation on metformin pharmacokinetics Diabetologia
  Abstract Aims/hypothesis The objective was to investigate if metformin pharmacokinetics is modulated by time-of-day in humans using empirical and mechanistic pharmacokinetic modelling techniques on a large clinical dataset. This study also aimed to generate and test hypotheses on the (...)

16 March

Diabetologia http://link.springer.com/

• 00:00
  Up Front Diabetologia

15 March

Diabetologia http://link.springer.com/

• 00:00
  Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice Diabetologia
  Abstract Aims/hypothesis N6-methyladenosine (m6A) mRNA methylation and m6A-related proteins (methyltransferase-like 3 [METTL3], methyltransferase-like 14 [METTL14] and YTH domain containing 1 [YTHDC1]) have been shown to regulate islet beta cell function and the pathogenesis of diabetes. (...)

14 March

Diabetologia http://link.springer.com/

• 00:00
  Upregulated TGF-?1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling Diabetologia
  Abstract Aims/hypothesis Glucagon-stimulated hepatic gluconeogenesis contributes to endogenous glucose production during fasting. Recent studies suggest that TGF-? is able to promote hepatic gluconeogenesis in mice. However, the physiological relevance of serum TGF-? levels to human glucose (...)
• 00:00
  The effect of surgical weight loss on diabetes complications in individuals with class II/III obesity Diabetologia
  Abstract Aims/hypothesis The aim of this study was to determine the effect of bariatric surgery on diabetes complications in individuals with class II/III obesity (BMI > 35 kg/m2). Methods We performed a prospective cohort study of participants with obesity who underwent bariatric surgery. At (...)

13 March

Diabetologia http://link.springer.com/

• 00:00
  Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes Diabetologia
  Abstract Aims/hypothesis We previously demonstrated that N-glycosylation of plasma proteins and IgGs is different in children with recent-onset type 1 diabetes compared with their healthy siblings. To search for genetic variants contributing to these changes, we undertook a genetic association (...)
• 00:00
  Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice Diabetologia
  Abstract Aims/hypothesis Beta cells control glucose homeostasis via regulated production and secretion of insulin. This function arises from a highly specialised gene expression programme that is established during development and then sustained, with limited flexibility, in terminally (...)

10 March

Diabetologia http://link.springer.com/

• 00:00
  Drug target Mendelian randomisation: are we really instrumenting drug use? Reply to Anderson EL, Williams DM [letter] Diabetologia
• 00:00
  The prediabetes conundrum: striking the balance between risk and resources Diabetologia
  Abstract The current definition of prediabetes is controversial and subject to continuous debate. Nonetheless, prediabetes is a risk factor for type 2 diabetes, is highly prevalent and is associated with diabetic complications and mortality. Thereby, it has the potential to become a huge (...)
• 00:00
  Sex differences in type 2 diabetes Diabetologia
  Abstract The prevalence of type 2 diabetes mellitus is increasing in both sexes, but men are usually diagnosed at a younger age and lower body fat mass than women. Worldwide, an estimated 17.7 million more men than women have diabetes mellitus. Women appear to bear a greater risk factor burden (...)

8 March

Diabetologia http://link.springer.com/

• 00:00
  Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells Diabetologia
  Abstract Aims/hypothesis Transcriptome analyses revealed insulin-gene-derived transcripts in non-beta endocrine islet cells. We studied alternative splicing of human INS mRNA in pancreatic islets. Methods Alternative splicing of insulin pre-mRNA was determined by PCR analysis performed on (...)
• 00:00
  Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells Diabetologia
  Abstract Aims/hypothesis Transcriptome analyses revealed insulin-gene-derived transcripts in non-beta endocrine islet cells. We studied alternative splicing of human INS mRNA in pancreatic islets. Methods Alternative splicing of insulin pre-mRNA was determined by PCR analysis performed on (...)
• 00:00
  The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes Diabetologia
  Abstract Aims/hypothesis Insulitis is not present in all islets, and it is elusive in humans. Although earlier studies focused on islets that fulfilled certain criteria (e.g. ?15 CD45+ cells or ?6 CD3+ cells), there is a fundamental lack of understanding of the infiltration dynamics in terms of (...)
• 00:00
  The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes Diabetologia
  Abstract Aims/hypothesis Insulitis is not present in all islets, and it is elusive in humans. Although earlier studies focused on islets that fulfilled certain criteria (e.g. ?15 CD45+ cells or ?6 CD3+ cells), there is a fundamental lack of understanding of the infiltration dynamics in terms of (...)

7 March

Diabetologia http://link.springer.com/

• 00:00
  No insulin degludec dose adjustment required after aerobic exercise for people with type 1 diabetes: the ADREM study Diabetologia
  Abstract Aims/hypothesis It is generally recommended to reduce basal insulin doses after exercise to reduce the risk of post-exercise nocturnal hypoglycaemia. Based on its long t½, it is unknown whether such adjustments are required or beneficial for insulin degludec. Methods The ADREM study (...)
• 00:00
  No insulin degludec dose adjustment required after aerobic exercise for people with type 1 diabetes: the ADREM study Diabetologia
  Abstract Aims/hypothesis It is generally recommended to reduce basal insulin doses after exercise to reduce the risk of post-exercise nocturnal hypoglycaemia. Based on its long t½, it is unknown whether such adjustments are required or beneficial for insulin degludec. Methods The ADREM study (...)

2 March

Diabetologia http://link.springer.com/

• 00:00
  The utility of a type 2 diabetes polygenic score in addition to clinical variables for prediction of type 2 diabetes incidence in birth, youth and adult cohorts in an Indigenous study population Diabetologia
  Abstract Aims/hypothesis There is limited information on how polygenic scores (PSs), based on variants from genome-wide association studies (GWASs) of type 2 diabetes, add to clinical variables in predicting type 2 diabetes incidence, particularly in non-European-ancestry populations. Methods (...)
• 00:00
  The utility of a type 2 diabetes polygenic score in addition to clinical variables for prediction of type 2 diabetes incidence in birth, youth and adult cohorts in an Indigenous study population Diabetologia
  Abstract Aims/hypothesis There is limited information on how polygenic scores (PSs), based on variants from genome-wide association studies (GWASs) of type 2 diabetes, add to clinical variables in predicting type 2 diabetes incidence, particularly in non-European-ancestry populations. Methods (...)