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AbstractFunding AcknowledgementsType of funding sources: Public grant(s) – National budget only. Main funding source(s): Singapore Ministry of Health’s National Medical Research CouncilBackgroundThere are little data on the interplay between post-acute myocardial infarction (MI), left ventricular (...)
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AbstractFunding AcknowledgementsType of funding sources: Foundation. Main funding source(s): National Natural Science Foundation of ChinaBackgroundExploring the mechanisms of valvular heart disease (VHD) at the cellular level may be useful to identify new therapeutic targets; however, the (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundHypertrophic cardiomyopathy (HCM), characterized by unexplained left ventricular hypertrophy and outcomes ranging from normal life expectancy to heart failure and sudden cardiac death, has a global prevalence of about 1 in (...)
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AbstractFunding AcknowledgementsType of funding sources: Public Institution(s). Main funding source(s): Sia CH was supported by the National University of Singapore Yong Loo Lin School of Medicine’s Junior Academic Faculty SchemeBackgroundAortic stenosis (AS) is related to several (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundRheumatic heart disease (RHD) is a preventable valve disease following acute rheumatic fever. It results in >300,000 deaths annually worldwide (1). While commonly encountered in the developing world, the prevalence in (...)
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AbstractFunding AcknowledgementsType of funding sources: None.AimsSevere coronary calcification is a serious impediment to optimal stent expansion and can lead to stent failure and adverse outcomes. We hereby present Indian experience with intravascular lithotripsy(IVL) for the treatment of (...)
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AbstractFunding AcknowledgementsType of funding sources: None.Background/IntroductionThe landscape of aortic valve replacement (AVR) has evolved dramatically over the years, but long-term outcomes have yet to be comprehensively explored.PurposeTo compare long-term mortality among three AVR (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundStroke during Transcatheter Aortic Valve implantation (TAVI) is not an uncommon complication with potential devastating consequences. With the extension of TAVI to the low-risk patient, stroke prevention takes on increasing (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundNovel strategies to improve the long-term risk stratification of valvular surgery are urgently needed as a result of the increasing prevalence of valvular heart diseases globally.PurposeThis study aimed to evaluate the (...)
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AbstractFunding AcknowledgementsType of funding sources: Public Institution(s). Main funding source(s): La Trobe UniversityIntroductionmHealth technologies have evolved rapidly in recent years and are now widely implemented for the secondary prevention of coronary artery disease (CAD). While (...)
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AbstractFunding AcknowledgementsType of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): Terrals Technologies Private LimitedBackgroundDigital therapeutics (DTx) has emerged as a new approach in recent years making use of connected devices, smartphone software and (...)
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AbstractFunding AcknowledgementsType of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): Terrals Technologies Private LimitedBackgroundCardiovascular risk scores serve as a useful tool to reinforce the importance of lifestyle modifications and treatment compliance. (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundA large proportion of premature deaths are related to metabolic diseases in the young adult population. We examined the global trends and mortality of metabolic diseases using estimates from the Global Burden of Diseases, (...)
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AbstractFunding AcknowledgementsType of funding sources: Private company. Main funding source(s): Novartis Corporation Sdn BhdBackgroundHeart failure is a debilitating disease associated with multiple comorbidities and poor prognosis. Dyslipidemia, is the top 5 most common comorbidities, (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundLife after percutaneous coronary angioplasty (PTCA) has been sparsely studied unlike the plethora of studies after coronary bypass surgery (CABG). It is mandatory that the patient make life style changes and be drug (...)
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AbstractFunding AcknowledgementsType of funding sources: Foundation. Main funding source(s): The Japan Cardiovascular Research Foundation under a contract with Bayer YakuhinBackgroundThe AFIRE (Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery (...)
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AbstractFunding AcknowledgementsType of funding sources: None.Background and ObjectivesReal-world trends in the utility and type of gatekeeping studies in invasive coronary angiography (ICA) requires further investigation.MethodsWe identified outpatients who underwent noninvasive cardiac tests (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundPatients with embolic stroke of undetermined source (ESUS) have no immediate attributable cause despite initial evaluation. Occult paroxysmal atrial fibrillation (pAF) diagnosed on prolonged electrocardiographic monitoring (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundIncidences of rhythm disturbance in pregnant are commonly seen. Catheter ablation of arrhythmias has been shown to be effective and safe. Data on perinatal outcomes and results of zero-fluoroscopy catheter ablation in (...)
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AbstractFunding AcknowledgementsType of funding sources: None.Background and AimsAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia in post-cardiac surgery. It is associated with substantial morbidity and mortality, thus portending a significant burden to patients and the (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionOral Vitamin K antagonist (VKA) is still widely used for anticoagulation. Anticoagulation clinics are set up to monitor patients’ INR and adjust their VKA doses accordingly. Anticoagulation clinic in our centre introduced (...)
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AbstractFunding AcknowledgementsType of funding sources: Public grant(s) – National budget only. Main funding source(s): Ministry of Health MalaysiaBackgroundStroke secondary to atrial fibrillation (AF) is common and often associated with higher risk of stroke recurrence. Detection of AF is (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundRight ventricular apical (RVA) pacing deleterious effects on left ventricular ejection fraction (LVEF) had been demonstrated. Non-apical pacing, such as right ventricular mid-septal (RVMS) and His Bundle pacing, appear as (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundLeadless pacemakers (L-PM) are a new safe alternative technology for pacing the right ventricle. However, not enough information is available on their potential benefits for quality of life (QoL) in patients with L-PM. The (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionPatients with HFpEF usually have severe exercise intolerance which leads to poor quality of life. While SGLT2 inhibitors in HFrEF patients have been proven beneficial, with HFpEF it remains uncertain. This meta-analysis (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundSGLT2 inhibition has been a breakthrough approach in the treatment for heart failure. A most recent trial of Dapagliflozin has shown its robust benefit in patients with HFpEF and HFmrEF. However, the positive outcomes of (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundSodium glucose co-transporter 2 (SGLT2) inhibitors have been recommended in the practice guidelines for the treatment of patients with heart failure with reduced ejection fraction, however their effects among patients with (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundCardiovascular disease (CVD) is the leading cause of death in Central Asia. In 2019, crude mortality rate in the region was 348.13 per 100,000 population. Heart failure (HF) is important CVD subtype owing to even worse (...)
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AbstractFunding AcknowledgementsType of funding sources: Private company. Main funding source(s): Novartis Corporation Sdn BhdBackgroundIn real world settings, factors that may affect prognosis of HF patients include comorbidities, lack of guideline-directed medical therapies (GDMT) and (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundsBoth brain natriuretic peptide (BNP) and N-terminal proBNP (NT-pro BNP) are established biomarkers that are necessary in the diagnosis and management of heart failure (HF). Recently with the introduction of angiotensin (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundCardiac tamponade is a medical emergency which requires prompt medical intervention via pericardiocentesis. Diverse etiologies has been attributed, with malignancy and Tuberculous effusions being the leading causes. The aim (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundAntenatal diagnosis of single ventricle congenital heart disease (CHD) allows prenatal counselling, better parental preparation and support as well as improved perinatal management. Expectant parents frequently ask about (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundCOVID-19 has been reported to cause cardiac injury. It can be detected by an electrocardiogram (ECG), which may show markers that may predict clinical outcome. Robust data on the ECG abnormalities among COVID-19 patients (...)
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AbstractFunding AcknowledgementsType of funding sources: None.Background/Introduction24-hour Holter monitors have been used widely to assess patients with suspected and known arrhythmias. Recent studies have shown increased yield of arrhythmia detection with longer durations of Holter (...)
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AbstractFunding AcknowledgementsType of funding sources: None.ObjectivesTo determine the association between levels of triglyceride (TG) and all-cause mortality and cardiovascular outcomes. To evaluate the concentration of TG associated with the lower range and lowest risk of adverse outcomes (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundAcute myocardial infarction (AMI) remains a public health issue with high morbidity and mortality rates and significantly reduces patients' health-related quality of life. The identification of factors influencing coronary (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundMorphological features of neointimal tissue play a pivotal role in the pathophysiology of In-Stent Restenosis (ISR) after percutaneous coronary intervention, hence understanding these features and patterns is (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundOut-of-hospital cardiac arrest (OHCA) outcomes are unsatisfactory despite postcardiac arrest care. Early prediction of prognoses might help stratify patients and provide tailored therapy.PurposeIn this study, we derived and (...)
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AbstractFunding AcknowledgementsType of funding sources: None.ObjectiveTo determine the clinical feasibility of novel serum biomarkers by comparing them with conventional serum biomarkers in out-of-hospital cardiac arrest (OHCA) patients treated with target temperature management (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionStudies investigating the relationship between percutaneous coronary intervention operator volumes and patient adverse events largely, but not consistently, suggest an inverse association. A recent study of rotational (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundShorter duration of dual antiplatelet therapy after drug-eluting stent implantation is required in patients with high bleeding risk (HBR) irrespective of the presence of concomitant high thrombotic risk (HTR). The (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundOccurrence of hyperkalemia has been a great limitation in the full implementation of a guideline-directed medical therapy especially in patients with heart failure. Recent developments have exhibited the positive role of (...)
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AbstractFunding AcknowledgementsType of funding sources: Other. Main funding source(s): Industry Alignment Fund – Pre-positioning ProgrammeBackgroundEpicardial adipose tissue (EAT) is the visceral fat deposit within the pericardium that surrounds the heart and the coronary arteries. EAT volume (...)
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AbstractFunding AcknowledgementsType of funding sources: Public grant(s) – National budget only. Main funding source(s): Mosti TED1 grantBackgroundNo study has used interpretative Machine Learning (ML) algorithms to predict in-hospital mortality for the Asian elderly (65+). TIMI predicts (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionSTEMI carries the highest risk among the AMI and the mortality is influenced by many factors. Hospital delays are the most easily audited and should be analyzed and improved.MethodologyParticipants were adults aged > 19 (...)
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AbstractFunding AcknowledgementsType of funding sources: None.Background/IntroductionCoronavirus disease (COVID-19) continues to cause considerable morbidity and mortality worldwide. The complication in patients with severe COVID-19 disease include arrhythmias, peri-myocarditis (PM), and heart (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionFor detecting myocardial injury in severe and critical COVID-19, the electrocardiogram (ECG) is neither sensitive nor specific; but in a resource-poor environment, it remains relevant. Changes in the ECG can be a (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionIntravenous double-syringe technique (DST) of adenosine administration consists of an intravenous bolus of adenosine via three-way stopcock followed by an immediate 10-20ml sodium chloride 0.9% flush and is the (...)
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AbstractFunding AcknowledgementsType of funding sources: Public grant(s) – National budget only. Main funding source(s): Singapore National Medical Research CouncilSingapore Khoo Teck Puat Hospital STAR grantBackgroundAlthough a low insulin sensitivity (insulin resistance) has been considered as (...)
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AbstractFunding AcknowledgementsType of funding sources: None.Background/IntroductionStress echocardiography is an important test used in the evaluation of myocardial ischemia. Despite this, not much is known about sex differences between men and women undergoing stress echocardiography, with (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundLeptospirosis is a zoonotic disease caused by Leptospira species that remains endemic in the Philippines. In severe cases, patients present with multiple organ system failure such as acute renal failure and acute (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionAtrial fibrillation (AF) is a common arrhythmia that causes various complications if left untreated. Current primary care guidelines recommend administration of antiarrhythmic drugs (AAD) as the preferred treatment (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundAlthough current guidelines recommend the use of direct oral anticoagulants in patients with non-valvular atrial fibrillation (NVAF), the use of vitamin K antagonists (VKA) is still very widespread, especially in low to (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundDuring the COVID-19 pandemic, systematic switching patients of eligible patients with atrial fibrillation from warfarin to direct oral anticoagulants (DOACs) was encouraged to simplify drug dosing and obviate the need for (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundCardiovascular disease is the leading cause of death in chronic kidney disease (CKD) patients. Calcified coronary artery is highly prevalent and more severe among these group. Coronary calcium score was used as a risk (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundAsian Indians are affected at least a decade earlier with cardiovascular diseases (CVD), in their most productive midlife years as compared to people of European ancestry. This is the first study from Indian sub-continent (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionLeft ventricular thrombus (LVT) is a known complication of acute myocardial infarction (AMI) and other cardiomyopathies. LVT increases the risk of stroke and systemic embolism, hence treatment with oral anticoagulation is (...)
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AbstractFunding AcknowledgementsType of funding sources: Private company. Main funding source(s): A consortium of six companies in Korea (Daiichi Sankyo, Boston Scientific, Terumo, Biotronik, Qualitech Korea, and Dio).BackgroundPatients with coronary artery disease and impaired renal function (...)
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AbstractFunding AcknowledgementsType of funding sources: Public Institution(s). Main funding source(s): Ching-Hui Sia was supported by the National University of Singapore Yong Loo Lin School of Medicine's Junior Academic Fellowship Scheme.BackgroundFunctional mitral regurgitation (FMR) (...)
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AbstractFunding AcknowledgementsType of funding sources: Public Institution(s). Main funding source(s): Ching-Hui Sia was supported by the National University of Singapore Yong Loo Lin School of Medicine's Junior Academic Fellowship Scheme.BackgroundFunctional mitral regurgitation (FMR) is the (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundInfective endocarditis (IE) has been associated with an elevated mortality rate despite major advances in diagnostic and therapeutic methods for the past decades.Purposeto evaluate predictors of in-hospital all-cause (...)
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AbstractFunding AcknowledgementsType of funding sources: Public hospital(s). Main funding source(s): Sanming Project of Medicine in Shenzhen, China;HKU-SZH Fund for Shenzhen Key Medical DisciplineBackgroundProsthetic valve endocarditis (PVE) is a rare but serious complication following valvular (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundDiabetes is a well-known risk factor for cardiovascular diseases and continues to be a global public health challenge. In Australia, prevalence rates of diabetes increase with age with almost 1 in 5 older people reported (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundThe prevalence of coronary heart disease increases with age and older people accounted for a large proportion of patients presenting with coronary heart disease. Advancement in percutaneous coronary intervention (PCI) has (...)
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AbstractFunding AcknowledgementsType of funding sources: Public hospital(s). Main funding source(s): University of Hong Kong, Queen Mary HospitalObjectiveTo evaluate the association between pre-diabetes and cardiovascular events in patients treated with anthracyclines containing chemotherapy (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundPatients with chronic kidney disease, especially end-stage renal disease, exhibit a very high cardiovascular risk. In Vietnam, chronic kidney disease and cardiovascular disease (CVD) are very common in older people. (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundMyocardial infarction (MI), caused by partial or total interruption of myocardial blood supply, is among the leading causes of morbidity and death. It can go silent (undetected), or it can be a catastrophic occurrence with (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionDespite the recent advancements in the management of Complete Heart Block (CHB), the aetiology of CHB is still idiopathic in most of the cases. Our study explores this hitherto untouched aspect of complete heart (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundThe Amplatzer Amulet and Watchman devices are the two most frequently used devices for percutaneous LAA closure globally.AimTo evaluate the safety and clinical outcomes associated with these two devices in patients (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundRight heart and renal dysfunction occurring due to volume fluid redistribution remain a front-line issue in the development of the syndrome of congestion in chronic heart failure (HF). Quantitative total blood volume (TBV) (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundGlycemic control is an important clinical issue in the management of patients with heart failure (HF). Variability of Glycated hemoglobin A1c (HbA1c) has been proven to be a predictor of cardiovascular events. However, (...)
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AbstractFunding AcknowledgementsType of funding sources: Public hospital(s). Main funding source(s): Rajavithi hospitalIntroductionMyocardial infarction is one of the most common cardiovascular disease in the world including Thai population. The current treatment strategy is percutaneous (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionCoronary angiography (CAG) has been recommended for patients with well-established risk factors. However, striking rates of coronary angiograms were turning out to be normal and very little is known regarding the (...)
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AbstractFunding AcknowledgementsType of funding sources: Other. Main funding source(s): Monash University MalaysiaBackgroundIschaemic Heart Disease (IHD) is the leading cause of death in Malaysia (1), and there is an increasing trend in mortality due to IHD from 15.2% in 2019 to 17.2% in 2020 (...)
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AbstractFunding AcknowledgementsType of funding sources: Other. Main funding source(s): Institute of Cardiovascular disease, Madras Medical MissionBackgroundType 2 Diabetes (DM) is a pro-inflammatory state in the pathogenesis of Atherosclerosis with the presence of many active proteins, of (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundAtherosclerosis is inherently an inflammatory process, with a complex interplay of inflammatory markers. It is established that these inflammatory markers play an important role in patients of Coronary Artery Disease(CAD) (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundPrevious studies have shown that females with type 2 diabetes mellitus (T2DM) may have an excess mortality risk compared to males. Furthermore, other studies have reported sex differences in managing cardiovascular risk (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionIn 2012, coronary heart disease and stroke are the leading causes of death worldwide, accounting for more than 31% of deaths from all causes. In 2020, PH statistics showed that ischemic heart diseases were the leading (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundCoronavirus disease 2019 (Covid-19) has become a global pandemic. Covid-19 increases morbidity in patients with underlying cardiovascular disease. The six-minute walk test (6MWT) is a simple test for assessing (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundThe management of coronary artery disease (CAD) has developed significantly in the last few decades. One of the therapeutic modalities that could be considered to patients with refractory angina caused by CAD is external (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundIntracoronary imaging and fractional flow reserve measurements (FFR) are helpful in optimisation of percutaneous coronary intervention (PCI) for patients with stable coronary artery disease, but their comparative efficacy (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionInfluenza infection has been linked to adverse cardiovascular events in coronary artery disease (CAD) patients. Despite the compelling link between influenza vaccine’s protective potential in observational studies, the (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundUntil now, right heart catheterization is still the gold standard for pulmonary hypertension examination, but this examination is invasive, has a risk of action, and is limited. Echocardiography provides an alternative (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundPulmonary hypertension (PH) is a high mortality and an uncrackable disease up to date. The complex pathophysiology is one of the reasons for only a view treatment that can be given to patients with PH. Recent studies have (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundCardiac rehabilitation (CR), an integral component of cardiovascular disease (CVD) management in developed countries, is yet to become mainstream in India. With the prevailing gross mismatch between the need and the (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionSickle cell disease (SCD) is an inherited disorder of globin chains that cause haemolysis, thrombosis and chronic organ damage. SCD affects multiple organs including the cardiovascular system. The two main subtypes of SCD (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionSickle cell disease (SCD) is an inherited disorder of globin chains that cause haemolysis and chronic organ damage. It is an autosomal recessive condition. SCD is a condition more prevalent in sub-saharan Africa. It is (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundAcute Coronary Syndrome (ACS) is a leading cause of demise in the Asia-Pacific region. Women, especially those more than 65 years old, do not seek treatment immediately because symptoms are usually atypical. A study done in (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundMyocardial Bridge (MB) over the coronary artery and myocardial coat (MC) over the cardiac veins are sometimes detected in angiography and cadaveric dissection. Left anterior descending (LAD) branch of left coronary artery (...)
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AbstractFunding AcknowledgementsType of funding sources: Public grant(s) – National budget only. Main funding source(s): This research is supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of (...)
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AbstractFunding AcknowledgementsType of funding sources: Public grant(s) – National budget only. Main funding source(s): Ministry of Higher Education, Malaysia (Fundamental Research Grant Scheme)BackgroundCardiovascular disease is the primary cause of death in Malaysia. Past studies have shown (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionIn December 2019, a novel Coronavirus disease 2019 (COVID-19) was discovered and spread rapidly worldwide. The virus spared no country in its contagiousness. The most common clinical manifestations are respiratory (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionCoronavirus disease 2019 (COVID-19) has caused significant morbidity and mortality worldwide and has been associated with several cardiac complications including myocarditis. COVID-19 patients with myocardial injury have (...)
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AbstractFunding AcknowledgementsType of funding sources: Public Institution(s). Main funding source(s): National University of Singapore Yong Loo Lin School of Medicine's Junior Academic Fellowship SchemeBackgroundThe optimal method of risk stratification of hypertrophic cardiomyopathy (HCM) (...)
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AbstractFunding AcknowledgementsType of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): Boston Scientific JapanBackgroundTranscatheter left atrial appendage closure (LAAC) provides an alternative to oral anticoagulation for thromboembolic risk reduction in patients (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundOne of the most common co-morbidities identified among COVID-19 patients was hypertension. Debates on use of Angiotensin-Converting Enzyme Inhibitors (ACEI) and Angiotensin-Receptor blockers (ARB) emerged due to an (...)
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AbstractFunding AcknowledgementsType of funding sources: Private company. Main funding source(s): Servier, FranceBackgroundHypertension poses a significant healthcare burden in Asia. Detection, treatment and control of hypertension are suboptimal, despite the existence of clear international (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundHyperkalemia is a common complication and increases the risk of cardiac arrhythmias and mortality in patients with type 2 diabetes (T2DM), especially in those with diabetic nephropathy. We investigated the risk of (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundPrevious studies have shown that the prevalence of cardiovascular diseases is related to the patient's age and gender differences, but the effect of age on platelet function remains controversial. Platelet function should (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundEpicardial adipose tissue (EAT) has garnered attention as a potential imaging biomarker for the risk stratification of cardiovascular diseases (CVD). However, the prognostic utility of EAT due to inter-ethnic differences (...)
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AbstractFunding AcknowledgementsType of funding sources: Public grant(s) – National budget only. Main funding source(s): NMRC COVID-19 Research FundObjectiveThis is the first prospective cohort study in Singapore to investigate the COVID-19 vaccine-associated myocarditis to understand its (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundStroke is a major global health issue and Climate change is the biggest and most urgent challenges. The Asia and Pacific region have been more vulnerable to climate change and extreme heat exposure than other regions of the (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundWe have witnessed a dramatic dip in adherence to cardiovascular health behaviors during the COVID-19 pandemic. Data from across the globe has shown that risk factors for cardiovascular disease (CVD) such as decreased (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundThe association between non-alcoholic fatty liver disease (NAFLD) with cardiovascular and cerebrovascular outcomes, as well as their clinical impact, has yet to be established in the literature.ObjectiveWe aim to evaluate (...)
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AbstractFunding AcknowledgementsType of funding sources: Public grant(s) – National budget only. Main funding source(s): Singapore National Medical Research Council grants: CSA-INV/0020/2017 and CS-IRG (MOH-000066)BackgroundHeart failure (HF) is a common but often unrecognized complication of (...)
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AbstractFunding AcknowledgementsType of funding sources: Private hospital(s). Main funding source(s): Jakarta Heart CenterBackgroundManaging ST-Segment Elevation Myocardial Infarction (STEMI) patients was always challenging for Healthcare Professionals (HCP) to pursue time-sensitive treatment.1 (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundA high body mass index (BMI) is seems to be associated with an increased incidence of coronary artery disease. If the affected person is young, the consequences are more tragic. There are variable information on the (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundPulmonary arterial hypertension (PAH) is a disease characterised by an increase in pulmonary vascular resistance and pulmonary artery pressure. Phosphodiesterase type 5 (PDE5) inhibitors, with sildenafil the earliest among (...)
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AbstractFunding AcknowledgementsType of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): Janssen Australia and New Zealand (Janssen-Cilag Pty Ltd)Pulmonary Arterial Hypertension (PAH) management strategies focus on lowering mortality risk, extending the patient’s (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundOCT is an excellent tool to determine plaque morphology in Acute Coronary Syndromes. While plaque rupture has been determined to be the dominant morphology in ST Elevation Myocardial Infarction, there is paucity of (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundThere is emerging evidence showing improvement in clinical outcomes with optical coherence tomography (OCT) and intravascular ultrasound (IVUS)-guided elective percutaneous coronary intervention (PCI). Yet data supporting (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionMany patients with CCS are usually referred for invasive treatment early on first come first serve basis. Proper clinical assessment of the severity of symptoms and optimization of the medical therapy lack before referral (...)
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AbstractFunding AcknowledgementsType of funding sources: Private hospital(s). Main funding source(s): Jakarta Heart CenterBackgroundCOVID-19 became a main health problem and causes heavy impact, especially for healthcare system. Managing ST-Segment Elevation Myocardial Infarction (STEMI) (...)
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AbstractFunding AcknowledgementsType of funding sources: Public Institution(s). Main funding source(s): RistekdiktiBackground and AimsThe SARS-CoV-2 virus can infect adipocyte cells via ACE2 Receptor thus triggering ACE2 overexpression and cytokine storms which cause lethal complications. (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundAtrial fibrillation (AF) and Diabetes mellitus (DM) often coexist. As DM is considered while calculating the thromboembolic risk for AF patients, little is known about the prescription pattern of antithrombotic therapies in (...)
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AbstractFunding AcknowledgementsType of funding sources: None.TitleThe Effect of Therapeutic Dose Anticoagulation Versus Prophylactic Dose Anticoagulation in Reducing Venous Thromboembolism (VTE), Arterial Thrombosis (ATE) or Death Events Among Hospitalized Non-critically Ill COVID-19 Patients: (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundAlthough clopidogrel is the basic drug for antiplatelet therapy in patients with coronary artery disease (CAD). However, loss of function (LOF) allelic variants located within the CYP2C19 gene may reduce the production of (...)
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AbstractFunding AcknowledgementsType of funding sources: Foundation. Main funding source(s): British Heart FoundationAcademy of Medical SciencesBackgroundLV myocardial interstitial fibrosis has been reported to influence LA morphology and function via LV remodelling and diastolic dysfunction. (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionDespite optimal medical treatment, the 5-years mortality and HF readmission rate was 75.3% and 48.5%, respectively. The current guidelines recommended cardiac resynchronization therapy (CRT) by implanting biventricular (...)
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AbstractFunding AcknowledgementsType of funding sources: None.ObjectivesConflicting results regarding sex-based differences in the outcomes of out-of-hospital cardiac arrest (OHCA) patients have been reported. Furthermore, no study has examined whether differences in in-hospital interventions (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionSelexipag is an oral selective prostacyclin IP receptor agonist indicated for treatment of pulmonary arterial hypertension (PAH). Data on its real-world safety and efficacy in Asians is lacking.PurposeWe sought to (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundThe introduction of the oral prostanoid selexipag for treating severe adult pulmonary arterial hypertension (PH) has contributed to reduced rates of death and secondary complications in PAH. Pediatric physicians have (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundThe growing prevalence of metabolic diseases is a major concern. We sought to examine the global trends and mortality of metabolic diseases using estimates from the Global Burden of Diseases, Injuries and Risk Factors Study (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionThe archipelagic nature of the Philippines is unique and the geographic areas of responsibility for ST elevation myocardial infarction patients should be defined.MethodologyThe list of registered PCI capable hospitals and (...)
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AbstractFunding AcknowledgementsType of funding sources: None.Background and PurposeLongitudinal change in the left atrium prior to the onset of heart failure has not been as well studied as left atrial (LA) dysfunction in pre-existing heart failure. This study used cardiac magnetic resonance (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionOut of hospital cardiac arrest (OHCA) carries a high rate of mortality and can be due to cardiac or non-cardiac causes. We reviewed consecutive patients presenting with OHCA to the emergency department of a regional (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionTo address the risks of transmission by COVID-19, various recommendations been released by medical societies, which include strongly advocating for the use of personal protective equipment. In addition, hands-only (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionEmbolic strokes of undetermined source (ESUS) constitute a significant proportion of all ischemic strokes, but sex-based comparisons of clinical characteristics and outcomes of ESUS patients have not been well explored. (...)
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AbstractFunding AcknowledgementsType of funding sources: None.ObjectiveTo investigate the prevalence of arterial thromboembolic (TE) complications including stroke, peripheral arterial disease (PAD) and myocardial infarction (MI) and mortality among COVID-19 patients admitted to an ICU at a (...)
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AbstractFunding AcknowledgementsType of funding sources: Public Institution(s). Main funding source(s): National Medical Research Council, Ministry of Health, Singapore and the Lee FoundationBackgroundLeft ventricular (LV) mass and coronary artery calcium score (CACS) are both independent (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundManagement and pathophysiology of diabetes and hypertension has always been the centre of research, with new insights being found consistently. CVD is the major cause of mortality in patients with type 2 diabetes and (...)
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AbstractFunding AcknowledgementsType of funding sources: None.Background/IntroductionAtrial fibrillation is common. Cardioversion to restore sinus rhythm is successful in over 90% of cases, but reversion to atrial fibrillation within a year occurs in the majority. Although predictors of (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionCatheter ablation (CA) is used as a treatment option in selected patients with atrial fibrillation (AF) and heart failure with reduced ejection fraction (HFrEF) as studies have shown that it reduces heart failure (HF) (...)
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AbstractFunding AcknowledgementsType of funding sources: Public Institution(s). Main funding source(s): National Key Research and Development Program of ChinaBackgroundPara-Hisian paroxysmal supraventricular tachycardia (PSVT) is associated with a higher risk of atrioventricular block due to (...)
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AbstractFunding AcknowledgementsType of funding sources: None.BackgroundAlthough bradyarrhythmias may occur in pregnant patients, there are few data on their management, pregnancy course and perinatal outcomes.PurposeTo evaluate the effects of bradyarrhythmias on the course and outcomes of (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionTransthyretin cardiac amyloidosis (ATTR-CA) is an emerging cause of heart failure (HF) and is associated with cardiac mass hypertrophy and voltage impairment, but little is known on how theses markers interplay with (...)
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AbstractFunding AcknowledgementsType of funding sources: Private company. Main funding source(s): Novartis (Thailand) LimitedBackground/IntroductionHeart failure (HF) is a major health problem due to its significant prevalence, disease burden and cost, mainly driven by high rates of (...)
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AbstractFunding AcknowledgementsType of funding sources: None.IntroductionSacubitril/Valsartan is the cornerstone in the treatment of heart failure with reduced ejection fraction (HFrEF). However, there is limited data on their risk-benefit in patients with acute heart failure requiring (...)