30 June

J Am Soc Nephrol https://jasn.asnjournals.org/

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  Predicting Future Outcomes from Kidney Biopsies with MCD/FSGS Lesions: Opportunities and Limitations - Anders, H.-J., Boor, P. J Am Soc Nephrol
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  Kidney Health Disparities: The Goal is Elimination - Wesson, D. E. J Am Soc Nephrol
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  Equitable Transplantation: A Modifiable Risk Factor for Disparities in Mortality in ESKD - Laster, M., Norris, K. C. J Am Soc Nephrol
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  Navigating to Kidney Health Equity - Griffith, D. M., Umeukeje, E. M. J Am Soc Nephrol
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  United States Renal Data System Spotlight on Racial and Ethnic Health Equity: Progress, but Much Remains to Discover, Understand, and Improve - Johansen, K. L., Powe, N. R. J Am Soc Nephrol
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  Looking Upstream-The Role of Primary Care in Addressing US Race Inequities in Kidney Health - Boulware, L. E. J Am Soc Nephrol
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  Culturally Concordant Community-Health Workers: Building Sustainable Community-Based Interventions that Eliminate Kidney Health Disparities - Cervantes, L., Robinson, B. M., Steiner, J. F., Myaskovsky, L. J Am Soc Nephrol
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  Recognizing the Potential Importance of Religion and Spirituality in the Care of Black Americans with Kidney Failure - Gelfand, S. L., Fitchett, G., Moss, A. H. J Am Soc Nephrol
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  Racial and Ethnic Disparities in Home Dialysis Use in the United States: Barriers and Solutions - Rizzolo, K., Cervantes, L., Shen, J. I. J Am Soc Nephrol
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  Lack of Cultural and Language Concordant Nutrition Education for Hispanic/Latinx Individuals with CKD: A Call to Action - Perez, L. M., Biruete, A. J Am Soc Nephrol
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  Transplantation Mediates Much of the Racial Disparity in Survival from Childhood-Onset Kidney Failure - Becerra, A. Z., Chan, K. E., Eggers, P. W., Norton, J., Kimmel, P. L., Schulman, I. H., Mendley, S. R. J Am Soc Nephrol
  Background The role of kidney transplantation in differential survival in Black and White patients with childhood-onset kidney failure is unexplored. Methods We analyzed 30-year cohort data of children beginning RRT before 18 years of age between January 1980 and December 2017 (n=28,337) in (...)
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  Maturation of GFR in Term-Born Neonates: An Individual Participant Data Meta-Analysis - Smeets, N. J. L., IntHout, J., van der Burgh, M. J. P., Schwartz, G. J., Schreuder, M. F., de Wildt, S. N. J Am Soc Nephrol
  Background The evidence from individual studies to support the maturational pattern of GFR in healthy, term-born neonates is inconclusive. We performed an individual participant data (IPD) meta-analysis of reported measured GFR (mGFR) data, aiming to establish neonatal GFR reference values. (...)
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  A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection - Hassler, L., Wysocki, J., Gelarden, I., Sharma, I., Tomatsidou, A., Ye, M., Gula, H., Nicoleascu, V., Randall, G., Pshenychnyi, S., Khurram, N., Kanwar, Y., Missiakas, D., Henkin, J., Yeldandi, A., Batlle, D. J Am Soc Nephrol
  Background Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) uses full-length angiotensin converting enzyme 2 (ACE2) as a main receptor to enter target cells. The goal of this study was to demonstrate the preclinical efficacy of a novel soluble ACE2 protein with increased (...)
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  Single-Cell Chromatin and Gene-Regulatory Dynamics of Mouse Nephron Progenitors - Hilliard, S., Tortelote, G., Liu, H., Chen, C.-H., El-Dahr, S. S. J Am Soc Nephrol
  Background We reasoned that unraveling the dynamic changes in accessibility of genomic regulatory elements and gene expression at single-cell resolution will inform the basic mechanisms of nephrogenesis. Methods We performed single-cell ATAC-seq and RNA-seq both individually (singleomes; (...)
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  Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells - Schepelmann, M., Ranieri, M., Lopez-Fernandez, I., Webberley, T. S., Brennan, S. C., Yarova, P. L., Graca, J., Hanif, U.-K., Mu?ller, C., Manhardt, T., Salzmann, M., Quasnichka, H., Price, S. A., Ward, D. T., Gilbert, T., Matchkov, V. V., Fenton, R. A., Herberger, A., Hwong, J., Santa Maria, C., Tu, C.-L., Kallay, E., Valenti, G., Chang, W., Riccardi, D. J Am Soc Nephrol
  Background Impaired mineral ion metabolism is a hallmark of CKD–metabolic bone disorder. It can lead to pathologic vascular calcification and is associated with an increased risk of cardiovascular mortality. Loss of calcium-sensing receptor (CaSR) expression in vascular smooth muscle cells (...)
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  Brief Early Life Angiotensin-Converting Enzyme Inhibition Offers Renoprotection in Sheep with a Solitary Functioning Kidney at 8 Months of Age - McArdle, Z., Singh, R. R., Bielefeldt-Ohmann, H., Moritz, K. M., Schreuder, M. F., Denton, K. M. J Am Soc Nephrol
  Background Children born with a solitary functioning kidney (SFK) are predisposed to develop hypertension and kidney injury. Glomerular hyperfiltration and hypertrophy contribute to the pathophysiology of kidney injury. Angiotensin-converting enzyme inhibition (ACEi) can mitigate (...)
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  Aqp2+ Progenitor Cells Maintain and Repair Distal Renal Segments - Gao, C., Zhang, L., Chen, E., Zhang, W. J Am Soc Nephrol
  Background Adult progenitor cells presumably demonstrate clonogenicity, self-renewal, and multipotentiality, and can regenerate cells under various conditions. Definitive evidence demonstrating the existence of such progenitor cells in adult mammalian kidneys is lacking. Method We performed (...)
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  The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia - Fritz, J., Brozek, W., Concin, H., Nagel, G., Kerschbaum, J., Lhotta, K., Ulmer, H., Zitt, E. J Am Soc Nephrol
  Background Insulin resistance, hypertension, hyperuricemia, and hypercholesterolemia are hypothesized to be important intermediates in the relationship between excess body weight and CKD risk. However, the magnitude of the total effect of excess body weight on ESKD mediated through these four (...)
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  Association of Proximal Tubular Secretory Clearance with Long-Term Decline in Cognitive Function - Lidgard, B., Bansal, N., Zelnick, L. R., Hoofnagle, A., Chen, J., Colaizzo, D., Dobre, M., Mills, K. T., Porter, A. C., Rosas, S. E., Sarnak, M. J., Seliger, S., Sondheimer, J., Tamura, M. K., Yaffe, K., Kestenbaum, B., the CRIC Study Investigators, The CRIC Study Investigators, Appel, Cohen, Feldman, Go, Lash, Nelson, Rahman, Rao, Shah, Unruh J Am Soc Nephrol
  Background People with chronic kidney disease (CKD) are at high risk for cognitive impairment and progressive cognitive decline. Retention of protein-bound organic solutes that are normally removed by tubular secretion is hypothesized to contribute to cognitive impairment in CKD. Methods We (...)
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  Hypomagnesemia, Hypocalcemia, and Tubulointerstitial Nephropathy Caused by Claudin-16 Autoantibodies - Figueres, L., Bruneau, S., Prot-Bertoye, C., Brideau, G., Neel, M., Griveau, C., Cheval, L., Bignon, Y., Dimitrov, J., Dejoie, T., Ville, S., Kandel-Aznar, C., Moreau, A., Houillier, P., Fakhouri, F. J Am Soc Nephrol
  Background Chronic hypomagnesemia is commonly due to diarrhea, alcoholism, and drugs. More rarely, it is caused by genetic defects in the effectors of renal magnesium reabsorption. Methods In an adult patient with acquired severe hypomagnesemia, hypocalcemia, tubulointerstitial nephropathy, (...)
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  Kidney Biopsy Features Most Predictive of Clinical Outcomes in the Spectrum of Minimal Change Disease and Focal Segmental Glomerulosclerosis - Zee, J., Liu, Q., Smith, A. R., Hodgin, J. B., Rosenberg, A., Gillespie, B. W., Holzman, L. B., Barisoni, L., Mariani, L. H., for the Nephrotic Syndrome Study Network (NEPTUNE), The NEPTUNE Members, Adler, Alter, Athavale, Atkinson, Avila-Casado, Bagnasco, Baker, Barisoni, Bidot, Blake, Bray, Canetta, Chernitskiy, Cooper, Dell, Dell, Derebail, Desmond, Eddy, Fermin, Fervenza, Flynn, Fornoni, Froment, Gadegbeku, Gaut, Gibson, Gillespie, Gipson, Greenbaum, Hewitt, Hingorani, Hladunewich, Hodgin, Hogan, Holzman, Itteera, Jefferson, Kallem, Kaskel, Klida, Kretzler, Kopp, Kretzler, Kurtz, (...) J Am Soc Nephrol
  Background Heterogeneity in disease course and treatment response among patients with MCD/FSGS necessitates a granular evaluation of kidney tissue features. This study aimed to identify histologic and ultrastructural descriptors of structural changes most predictive of clinical outcomes in the (...)
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  Calcium-Based Phosphate Binders and Plasma Oxalate Concentration in Dialysis Patients - Oka, Y., Miyazaki, M., Takatsu, S., Matsuda, H. J Am Soc Nephrol
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  Clinical Studies of Vaccine Efficacy - Ashby, D. J Am Soc Nephrol
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  Authors Reply: Calcium-Based Phosphate Binders and Plasma Oxalate Concentration in Dialysis Patients - Pfau, A., Knauf, F. J Am Soc Nephrol
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  Authors Reply: Clinical Studies of Vaccine Efficacy - Bell, S., Campbell, J., Lambourg, E., Mark, P. J Am Soc Nephrol
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  This Month's Highlights J Am Soc Nephrol
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  GFR and eGFR in Term-Born Neonates - Filler, G., Sharma, A. P., Exantus, J. J Am Soc Nephrol
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  Autoimmune Renal Calcium and Magnesium Wasting - Schlingmann, K. P., Konrad, M. J Am Soc Nephrol