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The United States Department of Health and Human Services launched the Advancing American Kidney Health Initiative in 2019, which included a goal of transforming dialysis care from an in-center to a largely home-based dialysis program. A substantial motivator for this transition is the (...)
19:00Empagliflozin Changes Urine Supersaturation by Decreasing pH and Increasing Citrate -
Harmacek, D., Pruijm, M., Burnier, M., Muller, M.-E., Ghajarzadeh-Wurzner, A., Bonny, O., Zanchi, A.
J Am Soc Nephrol
Clinical Trial registry name and registration number: Empagliflozin and Renal Oxygenation in Healthy Volunteers (EMPA-REIN), NCT03093103
19:00Arginase-1 Is Required for Macrophage-Mediated Renal Tubule Regeneration -
Shin, N. S., Marlier, A., Xu, L., Doilicho, N., Linberg, D., Guo, J., Cantley, L. G.
J Am Soc Nephrol
Background After kidney injury, macrophages transition from initial proinflammatory activation to a proreparative phenotype characterized by expression of arginase-1 (Arg1), mannose receptor 1 (Mrc1), and macrophage scavenger receptor 1 (Msr1). The mechanism by which these alternatively (...)
19:00Protein Kinase A Downregulation Delays the Development and Progression of Polycystic Kidney Disease -
Wang, X., Jiang, L., Thao, K., Sussman, C. R., LaBranche, T., Palmer, M., Harris, P. C., McKnight, G. S., Hoeflich, K. P., Schalm, S., Torres, V. E.
J Am Soc Nephrol
Background Upregulation of cAMP-dependent and cAMP-independent PKA signaling is thought to promote cystogenesis in polycystic kidney disease (PKD). PKA-I regulatory subunit RIα is increased in kidneys of orthologous mouse models. Kidney-specific knockout of RIα upregulates PKA (...)
19:00Intestinal Bacterial Translocation Contributes to Diabetic Kidney Disease -
Linh, H. T., Iwata, Y., Senda, Y., Sakai-Takemori, Y., Nakade, Y., Oshima, M., Nakagawa-Yoneda, S., Ogura, H., Sato, K., Minami, T., Kitajima, S., Toyama, T., Yamamura, Y., Miyagawa, T., Hara, A., Shimizu, M., Furuichi, K., Sakai, N., Yamada, H., Asanuma, K., Matsushima, K., Wada, T.
J Am Soc Nephrol
Background In recent years, many studies have focused on the intestinal environment to elucidate pathogenesis of various diseases, including kidney diseases. Impairment of the intestinal barrier function, the "leaky gut," reportedly contributes to pathologic processes in some disorders. (...)
19:00Reduced Glomerular Filtration in Diabetes Is Attributable to Loss of Density and Increased Resistance of Glomerular Endothelial Cell Fenestrations -
Finch, N. C., Fawaz, S. S., Neal, C. R., Butler, M. J., Lee, V. K., Salmon, A. J., Lay, A. C., Stevens, M., Dayalan, L., Band, H., Mellor, H. H., Harper, S. J., Shima, D. T., Welsh, G. I., Foster, R. R., Satchell, S. C.
J Am Soc Nephrol
Background Glomerular endothelial cell (GEnC) fenestrations are recognized as an essential component of the glomerular filtration barrier, yet little is known about how they are regulated and their role in disease. Methods We comprehensively characterized GEnC fenestral and functional renal (...)
19:00Factor H-Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy -
Marquez-Tirado, B., Gutierrez-Tenorio, J., Tortajada, A., Lucientes Continente, L., Caravaca-Fontan, F., Malik, T. H., Roldan Montero, R., Elias, S., Saiz Gonzalez, A., Fernandez-Juarez, G., Sanchez-Corral, P., Pickering, M. C., Praga, M., Rodriguez de Cordoba, S., Goicoechea de Jorge, E.
J Am Soc Nephrol
Background C3 glomerulopathy (C3G) is a heterogeneous group of chronic renal diseases characterized predominantly by glomerular C3 deposition and complement dysregulation. Mutations in factor H–related (FHR) proteins resulting in duplicated dimerization domains are prototypical of C3G, although (...)
19:00Tumor Lysis Syndrome and AKI: Beyond Crystal Mechanisms -
Arnaud, M., Loiselle, M., Vaganay, C., Pons, S., Letavernier, E., Demonchy, J., Fodil, S., Nouacer, M., Placier, S., Frere, P., Arrii, E., Lion, J., Mooney, N., Itzykson, R., Djediat, C., Puissant, A., Zafrani, L.
J Am Soc Nephrol
Background The pathophysiology of AKI during tumor lysis syndrome (TLS) is not well understood due to the paucity of data. We aimed to decipher crystal-dependent and crystal-independent mechanisms of TLS-induced AKI. Methods Crystalluria, plasma cytokine levels, and extracellular histones (...)
19:00Acute Kidney Injury Associates with Long-Term Increases in Plasma TNFR1, TNFR2, and KIM-1: Findings from the CRIC Study -
McCoy, I. E., Hsu, J. Y., Bonventre, J. V., Parikh, C. R., Go, A. S., Liu, K. D., Ricardo, A. C., Srivastava, A., Cohen, D. L., He, J., Chen, J., Rao, P. S., Hsu, C.-y., on behalf of the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators, Chronic Renal Insufficiency Cohort (CRIC) Study Investigators, Appel, Feldman, Lash, Nelson, Rahman, Shah, Unruh
J Am Soc Nephrol
Background Some markers of inflammation—TNF receptors 1 and 2 (TNFR1 and TNFR2)—are independently associated with progressive CKD, as is a marker of proximal tubule injury, kidney injury molecule 1 (KIM-1). However, whether an episode of hospitalized AKI may cause long-term changes in these (...)
19:00Immunosuppressant Medication Use in Patients with Kidney Allograft Failure: A Prospective Multicenter Canadian Cohort Study -
Knoll, G., Campbell, P., Chasse, M., Fergusson, D., Ramsay, T., Karnabi, P., Perl, J., House, A. A., Kim, J., Johnston, O., Mainra, R., Houde, I., Baran, D., Treleaven, D. J., Senecal, L., Tibbles, L. A., Hebert, M.-J., White, C., Karpinski, M., Gill, J. S.
J Am Soc Nephrol
Background Patients with kidney transplant failure have a high risk of hospitalization and death due to infection. The optimal use of immunosuppressants after transplant failure remains uncertain and clinical practice varies widely. Methods This prospective cohort study enrolled patients (...)
19:00Long-Term Efficacy and Safety of Repeated Rituximab to Maintain Remission in Idiopathic Childhood Nephrotic Syndrome: An International Study -
Chan, E. Y.-h., Yu, E. L. M., Angeletti, A., Arslan, Z., Basu, B., Boyer, O., Chan, C.-Y., Colucci, M., Dorval, G., Dossier, C., Drovandi, S., Ghiggeri, G. M., Gipson, D. S., Hamada, R., Hogan, J., Ishikura, K., Kamei, K., Kemper, M. J., Ma, A. L.-t., Parekh, R. S., Radhakrishnan, S., Saini, P., Shen, Q., Sinha, R., Subun, C., Teo, S., Vivarelli, M., Webb, H., Xu, H., Yap, H. K., Tullus, K.
J Am Soc Nephrol
Background Long-term outcomes after multiple courses of rituximab among children with frequently relapsing, steroid-dependent nephrotic syndrome (FRSDNS) are unknown. Methods A retrospective cohort study at 16 pediatric nephrology centers from ten countries in Asia, Europe, and North America (...)
19:00Molecular Characterization of Membranous Nephropathy -
Sealfon, R., Mariani, L., Avila-Casado, C., Nair, V., Menon, R., Funk, J., Wong, A., Lerner, G., Hayashi, N., Troyanskaya, O., Kretzler, M., Beck, L. H.
J Am Soc Nephrol
Background Molecular characterization of nephropathies may facilitate pathophysiologic insight, development of targeted therapeutics, and transcriptome-based disease classification. Although membranous nephropathy (MN) is a common cause of adult-onset nephrotic syndrome, the molecular pathways (...)