30 June

J Am Soc Nephrol https://jasn.asnjournals.org/

• 19:00
  Predicting Future Outcomes from Kidney Biopsies with MCD/FSGS Lesions: Opportunities and Limitations - Anders, H.-J., Boor, P. J Am Soc Nephrol
• 19:00
  Kidney Health Disparities: The Goal is Elimination - Wesson, D. E. J Am Soc Nephrol
• 19:00
  Equitable Transplantation: A Modifiable Risk Factor for Disparities in Mortality in ESKD - Laster, M., Norris, K. C. J Am Soc Nephrol
• 19:00
  Navigating to Kidney Health Equity - Griffith, D. M., Umeukeje, E. M. J Am Soc Nephrol
• 19:00
  United States Renal Data System Spotlight on Racial and Ethnic Health Equity: Progress, but Much Remains to Discover, Understand, and Improve - Johansen, K. L., Powe, N. R. J Am Soc Nephrol
• 19:00
  Looking Upstream-The Role of Primary Care in Addressing US Race Inequities in Kidney Health - Boulware, L. E. J Am Soc Nephrol
• 19:00
  Culturally Concordant Community-Health Workers: Building Sustainable Community-Based Interventions that Eliminate Kidney Health Disparities - Cervantes, L., Robinson, B. M., Steiner, J. F., Myaskovsky, L. J Am Soc Nephrol
• 19:00
  Recognizing the Potential Importance of Religion and Spirituality in the Care of Black Americans with Kidney Failure - Gelfand, S. L., Fitchett, G., Moss, A. H. J Am Soc Nephrol
• 19:00
  Racial and Ethnic Disparities in Home Dialysis Use in the United States: Barriers and Solutions - Rizzolo, K., Cervantes, L., Shen, J. I. J Am Soc Nephrol
• 19:00
  Lack of Cultural and Language Concordant Nutrition Education for Hispanic/Latinx Individuals with CKD: A Call to Action - Perez, L. M., Biruete, A. J Am Soc Nephrol
• 19:00
  Transplantation Mediates Much of the Racial Disparity in Survival from Childhood-Onset Kidney Failure - Becerra, A. Z., Chan, K. E., Eggers, P. W., Norton, J., Kimmel, P. L., Schulman, I. H., Mendley, S. R. J Am Soc Nephrol
  Background The role of kidney transplantation in differential survival in Black and White patients with childhood-onset kidney failure is unexplored. Methods We analyzed 30-year cohort data of children beginning RRT before 18 years of age between January 1980 and December 2017 (n=28,337) in (...)
• 19:00
  Maturation of GFR in Term-Born Neonates: An Individual Participant Data Meta-Analysis - Smeets, N. J. L., IntHout, J., van der Burgh, M. J. P., Schwartz, G. J., Schreuder, M. F., de Wildt, S. N. J Am Soc Nephrol
  Background The evidence from individual studies to support the maturational pattern of GFR in healthy, term-born neonates is inconclusive. We performed an individual participant data (IPD) meta-analysis of reported measured GFR (mGFR) data, aiming to establish neonatal GFR reference values. (...)
• 19:00
  A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection - Hassler, L., Wysocki, J., Gelarden, I., Sharma, I., Tomatsidou, A., Ye, M., Gula, H., Nicoleascu, V., Randall, G., Pshenychnyi, S., Khurram, N., Kanwar, Y., Missiakas, D., Henkin, J., Yeldandi, A., Batlle, D. J Am Soc Nephrol
  Background Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) uses full-length angiotensin converting enzyme 2 (ACE2) as a main receptor to enter target cells. The goal of this study was to demonstrate the preclinical efficacy of a novel soluble ACE2 protein with increased (...)
• 19:00
  Single-Cell Chromatin and Gene-Regulatory Dynamics of Mouse Nephron Progenitors - Hilliard, S., Tortelote, G., Liu, H., Chen, C.-H., El-Dahr, S. S. J Am Soc Nephrol
  Background We reasoned that unraveling the dynamic changes in accessibility of genomic regulatory elements and gene expression at single-cell resolution will inform the basic mechanisms of nephrogenesis. Methods We performed single-cell ATAC-seq and RNA-seq both individually (singleomes; (...)
• 19:00
  Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells - Schepelmann, M., Ranieri, M., Lopez-Fernandez, I., Webberley, T. S., Brennan, S. C., Yarova, P. L., Graca, J., Hanif, U.-K., Mu?ller, C., Manhardt, T., Salzmann, M., Quasnichka, H., Price, S. A., Ward, D. T., Gilbert, T., Matchkov, V. V., Fenton, R. A., Herberger, A., Hwong, J., Santa Maria, C., Tu, C.-L., Kallay, E., Valenti, G., Chang, W., Riccardi, D. J Am Soc Nephrol
  Background Impaired mineral ion metabolism is a hallmark of CKD–metabolic bone disorder. It can lead to pathologic vascular calcification and is associated with an increased risk of cardiovascular mortality. Loss of calcium-sensing receptor (CaSR) expression in vascular smooth muscle cells (...)
• 19:00
  Brief Early Life Angiotensin-Converting Enzyme Inhibition Offers Renoprotection in Sheep with a Solitary Functioning Kidney at 8 Months of Age - McArdle, Z., Singh, R. R., Bielefeldt-Ohmann, H., Moritz, K. M., Schreuder, M. F., Denton, K. M. J Am Soc Nephrol
  Background Children born with a solitary functioning kidney (SFK) are predisposed to develop hypertension and kidney injury. Glomerular hyperfiltration and hypertrophy contribute to the pathophysiology of kidney injury. Angiotensin-converting enzyme inhibition (ACEi) can mitigate (...)
• 19:00
  Aqp2+ Progenitor Cells Maintain and Repair Distal Renal Segments - Gao, C., Zhang, L., Chen, E., Zhang, W. J Am Soc Nephrol
  Background Adult progenitor cells presumably demonstrate clonogenicity, self-renewal, and multipotentiality, and can regenerate cells under various conditions. Definitive evidence demonstrating the existence of such progenitor cells in adult mammalian kidneys is lacking. Method We performed (...)
• 19:00
  The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia - Fritz, J., Brozek, W., Concin, H., Nagel, G., Kerschbaum, J., Lhotta, K., Ulmer, H., Zitt, E. J Am Soc Nephrol
  Background Insulin resistance, hypertension, hyperuricemia, and hypercholesterolemia are hypothesized to be important intermediates in the relationship between excess body weight and CKD risk. However, the magnitude of the total effect of excess body weight on ESKD mediated through these four (...)
• 19:00
  Association of Proximal Tubular Secretory Clearance with Long-Term Decline in Cognitive Function - Lidgard, B., Bansal, N., Zelnick, L. R., Hoofnagle, A., Chen, J., Colaizzo, D., Dobre, M., Mills, K. T., Porter, A. C., Rosas, S. E., Sarnak, M. J., Seliger, S., Sondheimer, J., Tamura, M. K., Yaffe, K., Kestenbaum, B., the CRIC Study Investigators, The CRIC Study Investigators, Appel, Cohen, Feldman, Go, Lash, Nelson, Rahman, Rao, Shah, Unruh J Am Soc Nephrol
  Background People with chronic kidney disease (CKD) are at high risk for cognitive impairment and progressive cognitive decline. Retention of protein-bound organic solutes that are normally removed by tubular secretion is hypothesized to contribute to cognitive impairment in CKD. Methods We (...)
• 19:00
  Hypomagnesemia, Hypocalcemia, and Tubulointerstitial Nephropathy Caused by Claudin-16 Autoantibodies - Figueres, L., Bruneau, S., Prot-Bertoye, C., Brideau, G., Neel, M., Griveau, C., Cheval, L., Bignon, Y., Dimitrov, J., Dejoie, T., Ville, S., Kandel-Aznar, C., Moreau, A., Houillier, P., Fakhouri, F. J Am Soc Nephrol
  Background Chronic hypomagnesemia is commonly due to diarrhea, alcoholism, and drugs. More rarely, it is caused by genetic defects in the effectors of renal magnesium reabsorption. Methods In an adult patient with acquired severe hypomagnesemia, hypocalcemia, tubulointerstitial nephropathy, (...)
• 19:00
  Kidney Biopsy Features Most Predictive of Clinical Outcomes in the Spectrum of Minimal Change Disease and Focal Segmental Glomerulosclerosis - Zee, J., Liu, Q., Smith, A. R., Hodgin, J. B., Rosenberg, A., Gillespie, B. W., Holzman, L. B., Barisoni, L., Mariani, L. H., for the Nephrotic Syndrome Study Network (NEPTUNE), The NEPTUNE Members, Adler, Alter, Athavale, Atkinson, Avila-Casado, Bagnasco, Baker, Barisoni, Bidot, Blake, Bray, Canetta, Chernitskiy, Cooper, Dell, Dell, Derebail, Desmond, Eddy, Fermin, Fervenza, Flynn, Fornoni, Froment, Gadegbeku, Gaut, Gibson, Gillespie, Gipson, Greenbaum, Hewitt, Hingorani, Hladunewich, Hodgin, Hogan, Holzman, Itteera, Jefferson, Kallem, Kaskel, Klida, Kretzler, Kopp, Kretzler, Kurtz, (...) J Am Soc Nephrol
  Background Heterogeneity in disease course and treatment response among patients with MCD/FSGS necessitates a granular evaluation of kidney tissue features. This study aimed to identify histologic and ultrastructural descriptors of structural changes most predictive of clinical outcomes in the (...)
• 19:00
  Calcium-Based Phosphate Binders and Plasma Oxalate Concentration in Dialysis Patients - Oka, Y., Miyazaki, M., Takatsu, S., Matsuda, H. J Am Soc Nephrol
• 19:00
  Clinical Studies of Vaccine Efficacy - Ashby, D. J Am Soc Nephrol
• 19:00
  Authors Reply: Calcium-Based Phosphate Binders and Plasma Oxalate Concentration in Dialysis Patients - Pfau, A., Knauf, F. J Am Soc Nephrol
• 19:00
  Authors Reply: Clinical Studies of Vaccine Efficacy - Bell, S., Campbell, J., Lambourg, E., Mark, P. J Am Soc Nephrol
• 19:00
  This Month's Highlights J Am Soc Nephrol
• 19:00
  GFR and eGFR in Term-Born Neonates - Filler, G., Sharma, A. P., Exantus, J. J Am Soc Nephrol
• 19:00
  Autoimmune Renal Calcium and Magnesium Wasting - Schlingmann, K. P., Konrad, M. J Am Soc Nephrol

31 May

J Am Soc Nephrol https://jasn.asnjournals.org/

• 19:00
  This Month's Highlights J Am Soc Nephrol
• 19:00
  More than a Marker: Arginase-1 in Kidney Repair - von Vietinghoff, S., Schmitt, R. J Am Soc Nephrol
• 19:00
  Of Mice and MAVS-Diabetic Kidney Disease and the Leaky Gut - Farre, R., Dejongh, S., Meijers, B. J Am Soc Nephrol
• 19:00
  Crystals or His(stones): Rethinking AKI in Tumor Lysis Syndrome - Basile, D. P. J Am Soc Nephrol
• 19:00
  Molecular Characterization of Membranous Nephropathy: Quo Vadis? - Fervenza, F. C., Glassock, R. J. J Am Soc Nephrol
• 19:00
  The Advancing American Kidney Health Initiative: The Challenge of Measuring Success - Quinn, R. R., Lam, N. N., Ravani, P., Oliver, M. J., Blake, P. G., Tonelli, M. J Am Soc Nephrol
• 19:00
  Cost Barriers to More Widespread Use of Peritoneal Dialysis in the United States - Baerman, E. A., Kaplan, J., Shen, J. I., Winkelmayer, W. C., Erickson, K. F. J Am Soc Nephrol
  The United States Department of Health and Human Services launched the Advancing American Kidney Health Initiative in 2019, which included a goal of transforming dialysis care from an in-center to a largely home-based dialysis program. A substantial motivator for this transition is the (...)
• 19:00
  Empagliflozin Changes Urine Supersaturation by Decreasing pH and Increasing Citrate - Harmacek, D., Pruijm, M., Burnier, M., Muller, M.-E., Ghajarzadeh-Wurzner, A., Bonny, O., Zanchi, A. J Am Soc Nephrol
  Clinical Trial registry name and registration number: Empagliflozin and Renal Oxygenation in Healthy Volunteers (EMPA-REIN), NCT03093103
• 19:00
  Arginase-1 Is Required for Macrophage-Mediated Renal Tubule Regeneration - Shin, N. S., Marlier, A., Xu, L., Doilicho, N., Linberg, D., Guo, J., Cantley, L. G. J Am Soc Nephrol
  Background After kidney injury, macrophages transition from initial proinflammatory activation to a proreparative phenotype characterized by expression of arginase-1 (Arg1), mannose receptor 1 (Mrc1), and macrophage scavenger receptor 1 (Msr1). The mechanism by which these alternatively (...)
• 19:00
  Protein Kinase A Downregulation Delays the Development and Progression of Polycystic Kidney Disease - Wang, X., Jiang, L., Thao, K., Sussman, C. R., LaBranche, T., Palmer, M., Harris, P. C., McKnight, G. S., Hoeflich, K. P., Schalm, S., Torres, V. E. J Am Soc Nephrol
  Background Upregulation of cAMP-dependent and cAMP-independent PKA signaling is thought to promote cystogenesis in polycystic kidney disease (PKD). PKA-I regulatory subunit RIα is increased in kidneys of orthologous mouse models. Kidney-specific knockout of RIα upregulates PKA (...)
• 19:00
  Intestinal Bacterial Translocation Contributes to Diabetic Kidney Disease - Linh, H. T., Iwata, Y., Senda, Y., Sakai-Takemori, Y., Nakade, Y., Oshima, M., Nakagawa-Yoneda, S., Ogura, H., Sato, K., Minami, T., Kitajima, S., Toyama, T., Yamamura, Y., Miyagawa, T., Hara, A., Shimizu, M., Furuichi, K., Sakai, N., Yamada, H., Asanuma, K., Matsushima, K., Wada, T. J Am Soc Nephrol
  Background In recent years, many studies have focused on the intestinal environment to elucidate pathogenesis of various diseases, including kidney diseases. Impairment of the intestinal barrier function, the "leaky gut," reportedly contributes to pathologic processes in some disorders. (...)
• 19:00
  Reduced Glomerular Filtration in Diabetes Is Attributable to Loss of Density and Increased Resistance of Glomerular Endothelial Cell Fenestrations - Finch, N. C., Fawaz, S. S., Neal, C. R., Butler, M. J., Lee, V. K., Salmon, A. J., Lay, A. C., Stevens, M., Dayalan, L., Band, H., Mellor, H. H., Harper, S. J., Shima, D. T., Welsh, G. I., Foster, R. R., Satchell, S. C. J Am Soc Nephrol
  Background Glomerular endothelial cell (GEnC) fenestrations are recognized as an essential component of the glomerular filtration barrier, yet little is known about how they are regulated and their role in disease. Methods We comprehensively characterized GEnC fenestral and functional renal (...)
• 19:00
  Factor H-Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy - Marquez-Tirado, B., Gutierrez-Tenorio, J., Tortajada, A., Lucientes Continente, L., Caravaca-Fontan, F., Malik, T. H., Roldan Montero, R., Elias, S., Saiz Gonzalez, A., Fernandez-Juarez, G., Sanchez-Corral, P., Pickering, M. C., Praga, M., Rodriguez de Cordoba, S., Goicoechea de Jorge, E. J Am Soc Nephrol
  Background C3 glomerulopathy (C3G) is a heterogeneous group of chronic renal diseases characterized predominantly by glomerular C3 deposition and complement dysregulation. Mutations in factor H–related (FHR) proteins resulting in duplicated dimerization domains are prototypical of C3G, although (...)
• 19:00
  Tumor Lysis Syndrome and AKI: Beyond Crystal Mechanisms - Arnaud, M., Loiselle, M., Vaganay, C., Pons, S., Letavernier, E., Demonchy, J., Fodil, S., Nouacer, M., Placier, S., Frere, P., Arrii, E., Lion, J., Mooney, N., Itzykson, R., Djediat, C., Puissant, A., Zafrani, L. J Am Soc Nephrol
  Background The pathophysiology of AKI during tumor lysis syndrome (TLS) is not well understood due to the paucity of data. We aimed to decipher crystal-dependent and crystal-independent mechanisms of TLS-induced AKI. Methods Crystalluria, plasma cytokine levels, and extracellular histones (...)
• 19:00
  Acute Kidney Injury Associates with Long-Term Increases in Plasma TNFR1, TNFR2, and KIM-1: Findings from the CRIC Study - McCoy, I. E., Hsu, J. Y., Bonventre, J. V., Parikh, C. R., Go, A. S., Liu, K. D., Ricardo, A. C., Srivastava, A., Cohen, D. L., He, J., Chen, J., Rao, P. S., Hsu, C.-y., on behalf of the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators, Chronic Renal Insufficiency Cohort (CRIC) Study Investigators, Appel, Feldman, Lash, Nelson, Rahman, Shah, Unruh J Am Soc Nephrol
  Background Some markers of inflammation—TNF receptors 1 and 2 (TNFR1 and TNFR2)—are independently associated with progressive CKD, as is a marker of proximal tubule injury, kidney injury molecule 1 (KIM-1). However, whether an episode of hospitalized AKI may cause long-term changes in these (...)
• 19:00
  Immunosuppressant Medication Use in Patients with Kidney Allograft Failure: A Prospective Multicenter Canadian Cohort Study - Knoll, G., Campbell, P., Chasse, M., Fergusson, D., Ramsay, T., Karnabi, P., Perl, J., House, A. A., Kim, J., Johnston, O., Mainra, R., Houde, I., Baran, D., Treleaven, D. J., Senecal, L., Tibbles, L. A., Hebert, M.-J., White, C., Karpinski, M., Gill, J. S. J Am Soc Nephrol
  Background Patients with kidney transplant failure have a high risk of hospitalization and death due to infection. The optimal use of immunosuppressants after transplant failure remains uncertain and clinical practice varies widely. Methods This prospective cohort study enrolled patients (...)
• 19:00
  Long-Term Efficacy and Safety of Repeated Rituximab to Maintain Remission in Idiopathic Childhood Nephrotic Syndrome: An International Study - Chan, E. Y.-h., Yu, E. L. M., Angeletti, A., Arslan, Z., Basu, B., Boyer, O., Chan, C.-Y., Colucci, M., Dorval, G., Dossier, C., Drovandi, S., Ghiggeri, G. M., Gipson, D. S., Hamada, R., Hogan, J., Ishikura, K., Kamei, K., Kemper, M. J., Ma, A. L.-t., Parekh, R. S., Radhakrishnan, S., Saini, P., Shen, Q., Sinha, R., Subun, C., Teo, S., Vivarelli, M., Webb, H., Xu, H., Yap, H. K., Tullus, K. J Am Soc Nephrol
  Background Long-term outcomes after multiple courses of rituximab among children with frequently relapsing, steroid-dependent nephrotic syndrome (FRSDNS) are unknown. Methods A retrospective cohort study at 16 pediatric nephrology centers from ten countries in Asia, Europe, and North America (...)
• 19:00
  Molecular Characterization of Membranous Nephropathy - Sealfon, R., Mariani, L., Avila-Casado, C., Nair, V., Menon, R., Funk, J., Wong, A., Lerner, G., Hayashi, N., Troyanskaya, O., Kretzler, M., Beck, L. H. J Am Soc Nephrol
  Background Molecular characterization of nephropathies may facilitate pathophysiologic insight, development of targeted therapeutics, and transcriptome-based disease classification. Although membranous nephropathy (MN) is a common cause of adult-onset nephrotic syndrome, the molecular pathways (...)
• 19:00
  Kidney Histopathology in ANCA-Associated Vasculitides Treated with Plasma Exchange - Casal Moura, M., Soler, M. J., Sethi, S., Fervenza, F. C., Specks, U. J Am Soc Nephrol
• 19:00
  Authors Reply: Kidney Histopathology in ANCA-Associated Vasculitides Treated with Plasma Exchange - Nezam, D., Porcher, R., Grolleau, F., Terrier, B., on behalf of the French Vasculitis Study Group, The French Vasculitis Study Group, Cottin, Faguer, Guillevin, Jourde-Chiche, Karras, Mouthon, Neel, Puechal, Pugnet, Samson, Taille, Terrier J Am Soc Nephrol
• 19:00
  Unveiling the Role of Additional Histological Parameters in ANCA-Associated Vasculitis - LImperio, V., Pagni, F. J Am Soc Nephrol
• 19:00
  Correction: The Impact of Vaccination on Incidence and Outcomes of SARS-CoV-2 Infection in Patients with Kidney Failure in Scotland J Am Soc Nephrol

29 April

J Am Soc Nephrol https://jasn.asnjournals.org/

• 19:00
  This Month's Highlights J Am Soc Nephrol
• 19:00
  Further Evidence for the Mucosal Origin of Pathogenic IgA in IgA Nephropathy - Cheung, C. K., Barratt, J. J Am Soc Nephrol
• 19:00
  A View on Cathepsin C as a Target for Therapy in AAV - Kain, R., Nackenhorst, M. C. J Am Soc Nephrol
• 19:00
  Clonal Hematopoiesis and CKD Progression - Niroula, A., Belizaire, R. J Am Soc Nephrol
• 19:00
  Enabling Patient Choice: The "Deciding Not to Decide" Option for Older Adults Facing Dialysis Decisions - Saeed, F., Moss, A. H., Duberstein, P. R., Fiscella, K. A. J Am Soc Nephrol
• 19:00
  SARS-CoV-2-Specific T Cell Responses Are Not Associated with Protection against Reinfection in Hemodialysis Patients - Shankar, S., Beckett, J., Tipton, T., Ogbe, A., Kasanyinga, M., Dold, C., Lumley, S., Dengu, F., Rompianesi, G., Elgilani, F., Longet, S., Deeks, A., Payne, R. P., Duncan, C. J. A., Richter, A., de Silva, T. I., Turtle, L., Bull, K., Barnardo, M., Friend, P. J., Dunachie, S. J., Hester, J., Issa, F., Barnes, E., Carroll, M. W., Klenerman, P. J Am Soc Nephrol
• 19:00
  DGAT2 Inhibition Potentiates Lipid Droplet Formation To Reduce Cytotoxicity in APOL1 Kidney Risk Variants - Chun, J., Riella, C. V., Chung, H., Shah, S. S., Wang, M., Magraner, J. M., Ribas, G. T., Ribas, H. T., Zhang, J.-Y., Alper, S. L., Friedman, D. J., Pollak, M. R. J Am Soc Nephrol
  Background Two variants in the gene encoding apolipoprotein L1 (APOL1) that are highly associated with African ancestry are major contributors to the large racial disparity in rates of human kidney disease. We previously demonstrated that recruitment of APOL1 risk variants G1 and G2 from the (...)
• 19:00
  Galactose-Deficient IgA1 B cells in the Circulation of IgA Nephropathy Patients Carry Preferentially Lambda Light Chains and Mucosal Homing Receptors - Zachova, K., Jemelkova, J., Kosztyu, P., Ohyama, Y., Takahashi, K., Zadrazil, J., Orsag, J., Matousovic, K., Galuszkova, D., Petejova, N., Mestecky, J., Raska, M. J Am Soc Nephrol
  Background IgA nephropathy (IgAN) primary glomerulonephritis is characterized by the deposition of circulating immune complexes composed of polymeric IgA1 molecules with altered O-glycans (Gd-IgA1) and anti-glycan antibodies in the kidney mesangium. The mesangial IgA deposits and serum IgA1 (...)
• 19:00
  Chimeric Fusion between Clostridium Ramosum IgA Protease and IgG Fc Provides Long-Lasting Clearance of IgA Deposits in Mouse Models of IgA Nephropathy - Xie, X., Li, J., Liu, P., Wang, M., Gao, L., Wan, F., Lv, J., Zhang, H., Jin, J. J Am Soc Nephrol
  Background IgA nephropathy is a common primary glomerulonephritis caused by mesangial deposition of poly-IgA complexes. The disease follows a variable course of clinical progression, with a high risk of kidney failure. Although no specific therapy is available, enzymatic strategies to clear (...)
• 19:00
  Targeting Cathepsin C in PR3-ANCA Vasculitis - Jerke, U., Eulenberg-Gustavus, C., Rousselle, A., Nicklin, P., Kreideweiss, S., Grundl, M. A., Eickholz, P., Nickles, K., Schreiber, A., Korkmaz, B., Kettritz, R. J Am Soc Nephrol
  Background The ANCA autoantigens proteinase 3 (PR3) and myeloperoxidase (MPO) are exclusively expressed by neutrophils and monocytes. ANCA-mediated activation of these cells is the key driver of the vascular injury process in ANCA-associated vasculitis (AAV), and neutrophil serine proteases (...)
• 19:00
  Serum Protein Exposure Activates a Core Regulatory Program Driving Human Proximal Tubule Injury - Lidberg, K. A., Muthusamy, S., Adil, M., Mahadeo, A., Yang, J., Patel, R. S., Wang, L., Bammler, T. K., Reichel, J., Yeung, C. K., Himmelfarb, J., Kelly, E. J., Akilesh, S. J Am Soc Nephrol
  Background The kidneys efficiently filter waste products while retaining serum proteins in the circulation. However, numerous diseases compromise this barrier function, resulting in spillage of serum proteins into the urine (proteinuria). Some studies of glomerular filtration suggest that (...)
• 19:00
  Interleukin-33 Exacerbates IgA Glomerulonephritis in Transgenic Mice Overexpressing B Cell Activating Factor - Wang, Y. M., Shaw, K., Zhang, G. Y., Chung, E. Y. M., Hu, M., Cao, Q., Wang, Y., Zheng, G., Wu, H., Chadban, S. J., McCarthy, H. J., Harris, D. C. H., Mackay, F., Grey, S. T., Alexander, S. I. J Am Soc Nephrol
  Background The cytokine IL-33 is an activator of innate lymphoid cells 2 (ILC2s) in innate immunity and allergic inflammation. B cell activating factor (BAFF) plays a central role in B cell proliferation and differentiation, and high levels of this protein cause excess antibody production, (...)
• 19:00
  Association of Clonal Hematopoiesis of Indeterminate Potential with Worse Kidney Function and Anemia in Two Cohorts of Patients with Advanced Chronic Kidney Disease - Vlasschaert, C., McNaughton, A. J. M., Chong, M., Cook, E. K., Hopman, W., Kestenbaum, B., Robinson-Cohen, C., Garland, J., Moran, S. M., Pare, G., Clase, C. M., Tang, M., Levin, A., Holden, R., Rauh, M. J., Lanktree, M. B. J Am Soc Nephrol
  Background Clonal hematopoiesis of indeterminate potential (CHIP) is an inflammatory premalignant disorder resulting from acquired genetic mutations in hematopoietic stem cells. This condition is common in aging populations and associated with cardiovascular morbidity and overall mortality, (...)
• 19:00
  Longitudinal TNFR1 and TNFR2 and Kidney Outcomes: Results from AASK and VA NEPHRON-D - Chen, T. K., Coca, S. G., Estrella, M. M., Appel, L. J., Coresh, J., Thiessen Philbrook, H., Obeid, W., Fried, L. F., Heerspink, H. J. L., Ix, J. H., Shlipak, M. G., Kimmel, P. L., Parikh, C. R., Grams, M. E., on behalf of the CKD Biomarkers Consortium (BioCon), CKD Biomarkers Consortium (BioCon), Ramachandran, Massaro, Clish, Schelling, Denburg, Furth, Warady, Bonventre, Waikar, McMahon, Sabbisetti, Coresh, Grams, Rebholz, Abraham, Tin, Parikh, Klein, Coca, Ferket, Nadkarni, Rhee, Kimmel, Gossett, Rovin, Shlipak, Sarnak, Levey, Inker, Foster, Gutierrez, Ix, Dubin, Seegmiller, Hostetter, (...) J Am Soc Nephrol
  Background Higher baseline levels of soluble TNF receptors (TNFR1 and TNFR2) have been associated with progressive CKD. Whether longitudinal changes in these biomarkers of inflammation are also associated with worse kidney outcomes has been less studied. Methods We evaluated associations of (...)
• 19:00
  Interventions To Attenuate Vascular Calcification Progression in Chronic Kidney Disease: A Systematic Review of Clinical Trials - Xu, C., Smith, E. R., Tiong, M. K., Ruderman, I., Toussaint, N. D. J Am Soc Nephrol
  Background Vascular calcification is associated with cardiovascular morbidity and mortality in people with CKD. Evidence-based interventions that may attenuate its progression in CKD remain uncertain. Methods We conducted a systematic review of prospective clinical trials of interventions to (...)
• 19:00
  Hematopoietic Stem Cell Transplant-Membranous Nephropathy Is Associated with Protocadherin FAT1 - Sethi, S., Madden, B., Casal Moura, M., Nasr, S. H., Klomjit, N., Gross, L., Negron, V., Charlesworth, M. C., Alexander, M. P., Leung, N., Specks, U., Fervenza, F. C., Haas, M. J Am Soc Nephrol
  Background Membranous nephropathy (MN) is a common cause of proteinuria in patients receiving a hematopoietic stem cell transplant (HSCT). The target antigen in HSCT-associated MN is unknown. Methods We performed laser microdissection and tandem mass spectrometry (MS/MS) of glomeruli from 250 (...)
• 19:00
  More Research is Still Needed To Support The Real-world Generalizability of The Benefits of Lifestyle Interventions for CKD - Huang, L., Zhang, F. J Am Soc Nephrol
• 19:00
  Authors Reply: More Research is Still Needed to Support the Real-World Generalizability of the Benefits of Lifestyle Interventions for Chronic Kidney Disease - Beetham, K. S., Coombes, J. S., Howden, E. J. J Am Soc Nephrol
• 19:00
  The Subcellular Localization of RRAGD - Ma, T., Zhang, L., Chen, L. J Am Soc Nephrol
• 19:00
  Authors Reply: The Subcellular Localization of RRAGD - Schlingmann, K. P., Jouret, F., Knoers, N. V. A. M., de Baaij, J. H. F. J Am Soc Nephrol
• 19:00
  Correction: Mycophenolate Mofetil after Rituximab for Childhood-Onset Complicated Frequently-Relapsing or Steroid-Dependent Nephrotic Syndrome J Am Soc Nephrol

31 March

J Am Soc Nephrol https://jasn.asnjournals.org/

• 19:00
  This Month's Highlights J Am Soc Nephrol
• 19:00
  New Insights into the Pivotal Roles of Claudins in Proximal Tubule Electrolyte Reabsorption - Aronson, P. S. J Am Soc Nephrol
• 19:00
  Endocytosis Begins inside the Cell - Beenken, A. J Am Soc Nephrol
• 19:00
  The Search for the Perfect Agent for Anemia Management in Chronic Kidney Disease - Locatelli, F., Del Vecchio, L. J Am Soc Nephrol
• 19:00
  Premature Death in Kidney Transplant Recipients: The Time for Trials is Now - Vinson, A. J., Singh, S., Chadban, S., Cherney, D., Gaber, O., Gill, J. S., Helgeson, E., Herzog, C. A., Jardine, M., Jha, V., Kasiske, B. L., Mannon, R. B., Michos, E. D., Mottl, A. K., Newby, K., Roy-Chaudhury, P., Sawinski, D., Sharif, A., Sridhar, V. S., Tuttle, K. R., Vock, D. M., Matas, A. J Am Soc Nephrol
• 19:00
  The Non-Inferiority Complex: What Do Non-Inferiority Trials Tell Us? - Assimon, M. M., Cutter, G. R., Bargman, J. M. J Am Soc Nephrol
• 19:00
  The Impact of Vaccination on Incidence and Outcomes of SARS-CoV-2 Infection in Patients with Kidney Failure in Scotland - Bell, S., Campbell, J., Lambourg, E., Watters, C., ONeil, M., Almond, A., Buck, K., Carr, E. J., Clark, L., Cousland, Z., Findlay, M., Joss, N., Metcalfe, W., Petrie, M., Spalding, E., Traynor, J. P., Sanu, V., Thomson, P., Methven, S., Mark, P. B. J Am Soc Nephrol
  Background Patients with kidney failure requiring KRT are at high risk of complications and death following SARS-CoV-2 infection, with variable antibody responses to vaccination reported. We investigated the effects of COVID-19 vaccination on the incidence of infection, hospitalization, and (...)
• 19:00
  Comparative Effectiveness of mRNA-based BNT162b2 Vaccine versus Adenovirus Vector-Based Ad26.COV2.S Vaccine for the Prevention of COVID-19 among Dialysis Patients - Brunelli, S. M., Sibbel, S., Karpinski, S., Marlowe, G., Walker, A. G., Giullian, J., Van Wyck, D., Kelley, T., Lazar, R., Zywno, M. L., Connaire, J. J., Young, A., Tentori, F. J Am Soc Nephrol
  Background Studies have demonstrated that mRNA-based SARS-CoV-2 vaccines are highly effective among patients on dialysis. Because individual vaccines may be differentially available or acceptable to patients, it is important to understand comparative effectiveness relative to other vaccines, (...)
• 19:00
  Claudin-10a Deficiency Shifts Proximal Tubular Cl- Permeability to Cation Selectivity via Claudin-2 Redistribution - Breiderhoff, T., Himmerkus, N., Meoli, L., Fromm, A., Sewerin, S., Kriuchkova, N., Nagel, O., Ladilov, Y., Krug, S. M., Quintanova, C., Stumpp, M., Garbe-Scho?nberg, D., Westernstro?er, U., Merkel, C., Brinkhus, M. A., Altmu?ller, J., Schweiger, M. R., Mu?ller, D., Mutig, K., Morawski, M., Halbritter, J., Milatz, S., Bleich, M., Gu?nzel, D. J Am Soc Nephrol
  Background The tight junction proteins claudin-2 and claudin-10a form paracellular cation and anion channels, respectively, and are expressed in the proximal tubule. However, the physiologic role of claudin-10a in the kidney has been unclear. Methods To investigate the physiologic role of (...)
• 19:00
  A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome - Widjaja, A. A., Shekeran, S. G., Adami, E., Ting, J. G. W., Tan, J., Viswanathan, S., Lim, S. Y., Tan, P. H., Hu?bner, N., Coffman, T., Cook, S. A. J Am Soc Nephrol
  Background Alport syndrome is a genetic disorder characterized by a defective glomerular basement membrane, tubulointerstitial fibrosis, inflammation, and progressive renal failure. IL-11 was recently implicated in fibrotic kidney disease, but its role in Alport syndrome is unknown. Methods (...)
• 19:00
  A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness - Issler, N., Afonso, S., Weissman, I., Jordan, K., Cebrian-Serrano, A., Meindl, K., Dahlke, E., Tziridis, K., Yan, G., Robles-Lopez, J. M., Tabernero, L., Patel, V., Kesselheim, A., Klootwijk, E. D., Stanescu, H. C., Dumitriu, S., Iancu, D., Tekman, M., Mozere, M., Jaureguiberry, G., Outtandy, P., Russell, C., Forst, A.-L., Sterner, C., Heinl, E.-S., Othmen, H., Tegtmeier, I., Reichold, M., Schiessl, I. M., Limm, K., Oefner, P., Witzgall, R., Fu, L., Theilig, F., Schilling, A., Shuster Biton, E., Kalfon, L., Fedida, A., Arnon-Sheleg, E., Ben Izhak, O., Magen, D., Anikster, Y., Schulze, H., (...) J Am Soc Nephrol
  Background The endocytic reabsorption of proteins in the proximal tubule requires a complex machinery and defects can lead to tubular proteinuria. The precise mechanisms of endocytosis and processing of receptors and cargo are incompletely understood. EHD1 belongs to a family of proteins (...)
• 19:00
  A Comprehensive Immune Cell Atlas of Cystic Kidney Disease Reveals the Involvement of Adaptive Immune Cells in Injury-Mediated Cyst Progression in Mice - Song, C. J., Li, Z., Ahmed, U. K. B., Bland, S. J., Yashchenko, A., Liu, S., Aloria, E. J., Lever, J. M., Gonzalez, N. M., Bickel, M. A., Giles, C. B., Georgescu, C., Wren, J. D., Lang, M. L., Benveniste, E. N., Harrington, L. E., Tsiokas, L., George, J. F., Jones, K. L., Crossman, D. K., Agarwal, A., Mrug, M., Yoder, B. K., Hopp, K., Zimmerman, K. A. J Am Soc Nephrol
  Background Inducible disruption of cilia-related genes in adult mice results in slowly progressive cystic disease, which can be greatly accelerated by renal injury. Methods To identify in an unbiased manner modifier cells that may be influencing the differential rate of cyst growth in injured (...)
• 19:00
  Lipopolysaccharide Pretreatment Prevents Medullary Vascular Congestion following Renal Ischemia by Limiting Early Reperfusion of the Medullary Circulation - McLarnon, S. R., Wilson, K., Patel, B., Sun, J., Sartain, C. L., Mejias, C. D., Musall, J. B., Sullivan, J. C., Wei, Q., Chen, J.-K., Hyndman, K. A., Marshall, B., Yang, H., Fogo, A. B., OConnor, P. M. J Am Soc Nephrol
  Background Vascular congestion of the renal medulla—trapped red blood cells in the medullary microvasculature—is a hallmark finding at autopsy in patients with ischemic acute tubular necrosis. Despite this, the pathogenesis of vascular congestion is not well defined. Methods In this study, to (...)
• 19:00
  alpha-Parvin Defines a Specific Integrin Adhesome to Maintain the Glomerular Filtration Barrier - Rogg, M., Maier, J. I., Van Wymersch, C., Helmsta?dter, M., Sammarco, A., Lindenmeyer, M., Zareba, P., Montanez, E., Walz, G., Werner, M., Endlich, N., Benzing, T., Huber, T. B., Schell, C. J Am Soc Nephrol
  Background The cell-matrix adhesion between podocytes and the glomerular basement membrane is essential for the integrity of the kidney’s filtration barrier. Despite increasing knowledge about the complexity of integrin adhesion complexes, an understanding of the regulation of these protein (...)
• 19:00
  Decreased Renal Gluconeogenesis Is a Hallmark of Chronic Kidney Disease - Verissimo, T., Faivre, A., Rinaldi, A., Lindenmeyer, M., Delitsikou, V., Veyrat-Durebex, C., Heckenmeyer, C., Fernandez, M., Berchtold, L., Dalga, D., Cohen, C., Naesens, M., Ricksten, S.-E., Martin, P.-Y., Pugin, J., Merlier, F., Haupt, K., Rutkowski, J. M., Moll, S., Cippa, P. E., Legouis, D., de Seigneux, S. J Am Soc Nephrol
  Introduction CKD is associated with alterations of tubular function. Renal gluconeogenesis is responsible for 40% of systemic gluconeogenesis during fasting, but how and why CKD affects this process and the repercussions of such regulation are unknown. Methods We used data on the renal (...)
• 19:00
  Endopeptidase Cleavage of Anti-Glomerular Basement Membrane Antibodies in vivo in Severe Kidney Disease: An Open-Label Phase 2a Study - Uhlin, F., Szpirt, W., Kronbichler, A., Bruchfeld, A., Soveri, I., Rostaing, L., Daugas, E., Lionet, A., Kamar, N., Rafat, C., Myslivecek, M., Tesar, V., Fernstro?m, A., Kjellman, C., Elfving, C., McAdoo, S., Mo?lne, J., Bajema, I., Sonesson, E., Segelmark, M. J Am Soc Nephrol
  Background The prognosis for kidney survival is poor in patients presenting with circulating anti–glomerular basement membrane (GBM) antibodies and severe kidney injury. It is unknown if treatment with an endopeptidase that cleaves circulating and kidney bound IgG can alter the prognosis. (...)
• 19:00
  Vaccine Effectiveness Against SARS-CoV-2 Infection and Severe Outcomes in the Maintenance Dialysis Population in Ontario, Canada - Oliver, M. J., Thomas, D., Balamchi, S., Ip, J., Naylor, K., Dixon, S. N., McArthur, E., Kwong, J., Perl, J., Atiquzzaman, M., Singer, J., Yeung, A., Hladunewich, M., Yau, K., Garg, A. X., Leis, J. A., Levin, A., Krajden, M., Blake, P. G. J Am Soc Nephrol
  Background Vaccination studies in the hemodialysis population have demonstrated decreased antibody response compared with healthy controls, but vaccine effectiveness for preventing SARS-CoV-2 infection and severe disease is undetermined. Methods We conducted a retrospective cohort study in (...)
• 19:00
  Roxadustat Versus Epoetin Alfa for Treating Anemia in Patients with Chronic Kidney Disease on Dialysis: Results from the Randomized Phase 3 ROCKIES Study - Fishbane, S., Pollock, C. A., El-Shahawy, M., Escudero, E. T., Rastogi, A., Van, B. P., Frison, L., Houser, M., Pola, M., Little, D. J., Guzman, N., Pergola, P. E. J Am Soc Nephrol
  Background Concerns regarding cardiovascular safety with current treatments for anemia in patients with dialysis-dependent (DD)-CKD have encouraged the development of alternatives. Roxadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, stimulates erythropoiesis by (...)
• 19:00
  Advanced Tertiary Lymphoid Tissues in Protocol Biopsies in Kidney Transplant Recipients: Addressing Additional Methods To Detect Intragraft B Cells - du Long, R., Florquin, S., Kers, J. J Am Soc Nephrol
• 19:00
  Authors Reply: Advanced Tertiary Lymphoid Tissues in Protocol Biopsies in Kidney Transplant Recipients: Addressing Additional Methods To Detect Intragraft B Cells - Sato, Y., Lee, Y. H., Taniguchi, K., Yoshikawa, T., Boor, P., Floege, J., Yanagita, M. J Am Soc Nephrol
• 19:00
  SARS-CoV-2 Vaccination in Kidney Transplant Recipients: Should We Consider Intradermal Vaccination? - Wijtvliet, V., Wissing, K. M., Abramowicz, D., Ledeganck, K. J. J Am Soc Nephrol
• 19:00
  Authors Reply: SARS-CoV-2 Vaccination in Kidney Transplant Recipients: Should We Consider Intradermal Vaccination? - Schrezenmeier, E., Sattler, A., Halleck, F., Budde, K. J Am Soc Nephrol
• 19:00
  Correction: Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity J Am Soc Nephrol

28 February

J Am Soc Nephrol https://jasn.asnjournals.org/

• 19:00
  This Month's Highlights J Am Soc Nephrol
• 19:00
  Urine Uromodulin and Genetics of its Variation - Franceschini, N., Le, T. H. J Am Soc Nephrol
• 19:00
  Cardiovascular Risk Prediction Scores in CKD: What Are We Missing? - Soomro, Q. H., Charytan, D. M. J Am Soc Nephrol
• 19:00
  Plasma Exchange in ANCA-Associated Vasculitis: For Whom (If Any)? - Walsh, M. J Am Soc Nephrol
• 19:00
  Extracellular Vesicles as Novel Players in Kidney Disease - Blijdorp, C. J., Burger, D., Llorente, A., Martens-Uzunova, E. S., Erdbru?gger, U. J Am Soc Nephrol
• 19:00
  Mechanisms and Models of Kidney Tubular Necrosis and Nephron Loss - Maremonti, F., Meyer, C., Linkermann, A. J Am Soc Nephrol
  Understanding nephron loss is a primary strategy for preventing CKD progression. Death of renal tubular cells may occur by apoptosis during developmental and regenerative processes. However, during AKI, the transition of AKI to CKD, sepsis-associated AKI, and kidney transplantation ferroptosis (...)
• 19:00
  Tissue Culture Models of AKI: From Tubule Cells to Human Kidney Organoids - Bejoy, J., Qian, E. S., Woodard, L. E. J Am Soc Nephrol
  AKI affects approximately 13.3 million people around the world each year, causing CKD and/or mortality. The mammalian kidney cannot generate new nephrons after postnatal renal damage and regenerative therapies for AKI are not available. Human kidney tissue culture systems can complement animal (...)
• 19:00
  Recurrence of Anti-Semaphorin 3B-Mediated Membranous Nephropathy after Kidney Transplantation - Fila, M., Debiec, H., Perrochia, H., Djouadi, N., Verpont, M.-C., Buob, D., Ronco, P. J Am Soc Nephrol
  Background Membranous nephropathy (MN) is rare in pediatric patients, although its diagnosis may be underestimated in children who are responsive to corticosteroid therapy prescribed for a suspicion of minimal change disease. It is most often associated with an autoimmune disease, (...)
• 19:00
  Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin - Joseph, C. B., Mariniello, M., Yoshifuji, A., Schiano, G., Lake, J., Marten, J., Richmond, A., Huffman, J. E., Campbell, A., Harris, S. E., Troyanov, S., Cocca, M., Robino, A., Theriault, S., Eckardt, K.-U., Wuttke, M., Cheng, Y., Corre, T., Kolcic, I., Black, C., Bruat, V., Concas, M. P., Sala, C., Aeschbacher, S., Schaefer, F., Bergmann, S., Campbell, H., Olden, M., Polasek, O., Porteous, D. J., Deary, I. J., Madore, F., Awadalla, P., Girotto, G., Ulivi, S., Conen, D., Wuehl, E., Olinger, E., Wilson, J. F., Bochud, M., Ko?ttgen, A., Hayward, C., Devuyst, (...) J Am Soc Nephrol
  Background Uromodulin, the most abundant protein excreted in normal urine, plays major roles in kidney physiology and disease. The mechanisms regulating the urinary excretion of uromodulin remain essentially unknown. Methods We conducted a meta-analysis of genome-wide association studies for (...)
• 19:00
  Vitamin C Deficiency Causes Cell Type-Specific Epigenetic Reprogramming and Acute Tubular Necrosis in a Mouse Model - Yu, Z., Xu, Z., Liang, Y., Yin, P., Shi, Y., Yu, J., Hao, J., Wang, T., Ci, W. J Am Soc Nephrol
  Background Vitamin C deficiency is found in patients with variable kidney diseases. However, the role of vitamin C as an epigenetic regulator in renal homeostasis and pathogenesis remains largely unknown. Methods We showed that vitamin C deficiency leads to acute tubular necrosis (ATN) using (...)
• 19:00
  Gentamicin Inhibits Ca2+ Channel TRPV5 and Induces Calciuresis Independent of the Calcium-Sensing Receptor-Claudin-14 Pathway - van Megen, W. H., Beggs, M. R., An, S.-W., Ferreira, P. G., Lee, J. J., Wolf, M. T., Alexander, R. T., Dimke, H. J Am Soc Nephrol
  Background Treatment with the aminoglycoside antibiotic gentamicin can be associated with severe adverse effects, including renal Ca2+ wasting. The underlying mechanism is unknown but it has been proposed to involve activation of the Ca2+-sensing receptor (CaSR) in the thick ascending limb, (...)
• 19:00
  Integrin alpha5 Is Regulated by miR-218-5p in Endothelial Progenitor Cells - Liu, J., Li, Y., Lyu, L., Xiao, L., Memon, A. A., Yu, X., Halim, A., Patel, S., Osman, A., Yin, W., Jiang, J., Naini, S., Lim, K., Zhang, A., Williams, J. D., Koester, R., Qi, K. Z., Fucci, Q.-A., Ding, L., Chang, S., Patel, A., Mori, Y., Chaudhari, A., Bao, A., Liu, J., Lu, T.-S., Siedlecki, A. J Am Soc Nephrol
  Background Endothelial cell injury is a common nidus of renal injury in patients and consistent with the high prevalence of AKI reported during the coronavirus disease 2019 pandemic. This cell type expresses integrin α5 (ITGA5), which is essential to the Tie2 signaling pathway. The (...)
• 19:00
  Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice - Maeoka, Y., Ferdaus, M. Z., Cornelius, R. J., Sharma, A., Su, X.-T., Miller, L. N., Robertson, J. A., Gurley, S. B., Yang, C.-L., Ellison, D. H., McCormick, J. A. J Am Soc Nephrol
  Background Mutations in the ubiquitin ligase scaffold protein Cullin 3 (CUL3) gene cause the disease familial hyperkalemic hypertension (FHHt). In the kidney, mutant CUL3 (CUL3-9) increases abundance of With-No-Lysine (K) Kinase 4 (WNK4), inappropriately activating sterile 20/SPS-1–related (...)
• 19:00
  Risk Prediction Models for Atherosclerotic Cardiovascular Disease in Patients with Chronic Kidney Disease: The CRIC Study - Bundy, J. D., Rahman, M., Matsushita, K., Jaeger, B. C., Cohen, J. B., Chen, J., Deo, R., Dobre, M. A., Feldman, H. I., Flack, J., Kallem, R. R., Lash, J. P., Seliger, S., Shafi, T., Weiner, S. J., Wolf, M., Yang, W., Allen, N. B., Bansal, N., He, J., the CRIC Study Investigators J Am Soc Nephrol
  Background Individuals with CKD may be at high risk for atherosclerotic cardiovascular disease (ASCVD). However, there are no ASCVD risk prediction models developed in CKD populations to inform clinical care and prevention. Methods We developed and validated 10-year ASCVD risk prediction (...)
• 19:00
  Angiopoietins as Prognostic Markers for Future Kidney Disease and Heart Failure Events after Acute Kidney Injury - Mansour, S. G., Bhatraju, P. K., Coca, S. G., Obeid, W., Wilson, F. P., Stanaway, I. B., Jia, Y., Thiessen-Philbrook, H., Go, A. S., Ikizler, T. A., Siew, E. D., Chinchilli, V. M., Hsu, C.-y., Garg, A. X., Reeves, W. B., Liu, K. D., Kimmel, P. L., Kaufman, J. S., Wurfel, M. M., Himmelfarb, J., Parikh, S. M., Parikh, C. R., for the ASSESS-AKI Consortium J Am Soc Nephrol
  Background The mechanisms underlying long-term sequelae after AKI remain unclear. Vessel instability, an early response to endothelial injury, may reflect a shared mechanism and early trigger for CKD and heart failure. Methods To investigate whether plasma angiopoietins, markers of vessel (...)
• 19:00
  Kidney Histopathology Can Predict Kidney Function in ANCA-Associated Vasculitides with Acute Kidney Injury Treated with Plasma Exchanges - Nezam, D., Porcher, R., Grolleau, F., Morel, P., Titeca-Beauport, D., Faguer, S., Karras, A., Solignac, J., Jourde-Chiche, N., Maurier, F., Sakhi, H., El Karoui, K., Mesbah, R., Carron, P. L., Audard, V., Ducloux, D., Paule, R., Augusto, J.-F., Aniort, J., Tiple, A., Rafat, C., Beaudreuil, S., Puechal, X., Gobert, P., Massy, Z., Hanrotel, C., Bally, S., Martis, N., Durel, C.-A., Desbuissons, G., Godmer, P., Hummel, A., Perrin, F., Neel, A., De Moreuil, C., Goulenok, T., Guerrot, D., Grange, S., Foucher, A., Deroux, A., Cordonnier, C., Guilbeau-Frugier, C., Modesto-Segonds, A., Nochy, D., (...) J Am Soc Nephrol
  Background Data from the PEXIVAS trial challenged the role of plasma exchange (PLEX) in ANCA-associated vasculitides (AAV). We aimed to describe kidney biopsy from patients with AAV treated with PLEX, evaluate whether histopathologic findings could predict kidney function, and identify which (...)
• 19:00
  Natural History of Bone Disease following Kidney Transplantation - Jorgensen, H. S., Behets, G., Bammens, B., Claes, K., Meijers, B., Naesens, M., Sprangers, B., Kuypers, D. R. J., Cavalier, E., DHaese, P., Evenepoel, P. J Am Soc Nephrol
  Background Knowledge of the effect of kidney transplantation on bone is limited and fragmentary. The aim of this study was to characterize the evolution of bone disease in the first post-transplant year. Methods We performed a prospective, observational cohort study in patients referred for (...)
• 19:00
  Autoimmune Podocytopathies: A Novel Sub-Group of Diseases from Childhood Idiopathic Nephrotic Syndrome - Ye, Q., Chen, A., Lai, E. Y., Mao, J. J Am Soc Nephrol
• 19:00
  Inflammation, Serum Iron, and Risk of Mortality and Cardiovascular Events in Nondialysis CKD Patients - Rostoker, G., Lepeytre, F., Rottembourg, J. J Am Soc Nephrol
• 19:00
  Authors Reply - Watts, A. J. B., Keller, K. H., Weins, A. J Am Soc Nephrol
• 19:00
  Authors Reply - Guedes, M., Robinson, B., Bieber, B., Pecoits-Filho, R. J Am Soc Nephrol
• 19:00
  Correction: Beneficial Effects of Myo-Inositol Oxygenase Deficiency in Cisplatin-Induced AKI J Am Soc Nephrol

31 January

J Am Soc Nephrol https://jasn.asnjournals.org/

• 19:00
  This Month's Highlights J Am Soc Nephrol
• 19:00
  Cisplatin-Induced Kidney Injury: Delivering the Goods - Curry, J. N., McCormick, J. A. J Am Soc Nephrol
• 19:00
  Comparing Plasma Donor-Derived Cell-free DNA to Indication Kidney Biopsy Tissue Gene Expression: Toward Understanding the Molecular Equivalents of Non-Invasive Tests - Kurian, S., Friedewald, J. J Am Soc Nephrol
• 19:00
  Secondary Immunodeficiency Related to Kidney Disease (SIDKD)--Definition, Unmet Need, and Mechanisms - Steiger, S., Rossaint, J., Zarbock, A., Anders, H.-J. J Am Soc Nephrol
  Kidney disease is a known risk factor for poor outcomes of COVID-19 and many other serious infections. Conversely, infection is the second most common cause of death in patients with kidney disease. However, little is known about the underlying secondary immunodeficiency related to kidney (...)
• 19:00
  Spatially Resolved Transcriptomic Analysis of Acute Kidney Injury in a Female Murine Model - Dixon, E. E., Wu, H., Muto, Y., Wilson, P. C., Humphreys, B. D. J Am Soc Nephrol
  Background Single-cell sequencing technologies have advanced our understanding of kidney biology and disease, but the loss of spatial information in these datasets hinders our interpretation of intercellular communication networks and regional gene expression patterns. New spatial (...)
• 19:00
  Acute Treatment Effects on GFR in Randomized Clinical Trials of Kidney Disease Progression - Neuen, B. L., Tighiouart, H., Heerspink, H. J. L., Vonesh, E. F., Chaudhari, J., Miao, S., Chan, T. M., Fervenza, F. C., Floege, J., Goicoechea, M., Herrington, W. G., Imai, E., Jafar, T. H., Lewis, J. B., Li, P. K.-T., Locatelli, F., Maes, B. D., Perrone, R. D., Praga, M., Perna, A., Schena, F. P., Wanner, C., Wetzels, J. F. M., Woodward, M., Xie, D., Greene, T., Inker, L. A., on behalf of CKD-EPI Clinical Trials J Am Soc Nephrol
  Background Acute changes in GFR can occur after initiation of interventions targeting progression of CKD. These acute changes complicate the interpretation of long-term treatment effects. Methods To assess the magnitude and consistency of acute effects in randomized clinical trials and (...)
• 19:00
  Gitelman-Like Syndrome Caused by Pathogenic Variants in mtDNA - Viering, D., Schlingmann, K. P., Hureaux, M., Nijenhuis, T., Mallett, A., Chan, M. M. Y., van Beek, A., van Eerde, A. M., Coulibaly, J.-M., Vallet, M., Decramer, S., Pelletier, S., Klaus, G., Ko?mhoff, M., Beetz, R., Patel, C., Shenoy, M., Steenbergen, E. J., Anderson, G., Bongers, E. M. H. F., Bergmann, C., Panneman, D., Rodenburg, R. J., Kleta, R., Houillier, P., Konrad, M., Vargas-Poussou, R., Knoers, N. V. A. M., Bockenhauer, D., de Baaij, J. H. F., the Genomics England Research (...) J Am Soc Nephrol
  Background Gitelman syndrome is the most frequent hereditary salt-losing tubulopathy characterized by hypokalemic alkalosis and hypomagnesemia. Gitelman syndrome is caused by biallelic pathogenic variants in SLC12A3, encoding the Na+-Cl– cotransporter (NCC) expressed in the distal convoluted (...)
• 19:00
  Xanthine Oxidoreductase Inhibitors Suppress the Onset of Exercise-Induced AKI in High HPRT Activity Urat1-Uox Double Knockout Mice - Hosoya, T., Uchida, S., Shibata, S., Tomioka, N. H., Matsumoto, K., Hosoyamada, M. J Am Soc Nephrol
  Background Hereditary renal hypouricemia type 1 (RHUC1) is caused by URAT1/SLC22A12 dysfunction, resulting in urolithiasis and exercise-induced AKI (EIAKI). However, because there is no useful experimental RHUC1 animal model, the precise pathophysiologic mechanisms underlying EIAKI have yet to (...)
• 19:00
  Kidney-Targeted Renalase Agonist Prevents Cisplatin-Induced Chronic Kidney Disease by Inhibiting Regulated Necrosis and Inflammation - Guo, X., Xu, L., Velazquez, H., Chen, T.-M., Williams, R. M., Heller, D. A., Burtness, B., Safirstein, R., Desir, G. V. J Am Soc Nephrol
  Background Repeated administration of cisplatin causes CKD. In previous studies, we reported that the kidney-secreted survival protein renalase (RNLS) and an agonist peptide protected mice from cisplatin-induced AKI. Methods To investigate whether kidney-targeted delivery of RNLS might (...)
• 19:00
  Bone Marrow-Derived RIPK3 Mediates Kidney Inflammation in Acute Kidney Injury - Martin-Sanchez, D., Guerrero-Mauvecin, J., Fontecha-Barriuso, M., Mendez-Barbero, N., Saiz, M. L., Lopez-Diaz, A. M., Sanchez-Nino, M. D., Carrasco, S., Cannata-Ortiz, P., Ruiz-Ortega, M., Ortiz, A., Sanz, A. B. J Am Soc Nephrol
  Background Receptor-interacting protein kinase 3 (RIPK3), a component of necroptosis pathways, may have an independent role in inflammation. It has been unclear which RIPK3-expressing cells are responsible for the anti-inflammatory effect of overall Ripk3 deficiency and whether Ripk3 (...)
• 19:00
  Using Machine Learning to Identify Metabolomic Signatures of Pediatric Chronic Kidney Disease Etiology - Lee, A. M., Hu, J., Xu, Y., Abraham, A. G., Xiao, R., Coresh, J., Rebholz, C., Chen, J., Rhee, E. P., Feldman, H. I., Ramachandran, V. S., Kimmel, P. L., Warady, B. A., Furth, S. L., Denburg, M. R., for the CKD Biomarkers Consortium J Am Soc Nephrol
  Background Untargeted plasma metabolomic profiling combined with machine learning (ML) may lead to discovery of metabolic profiles that inform our understanding of pediatric CKD causes. We sought to identify metabolomic signatures in pediatric CKD based on diagnosis: FSGS, obstructive uropathy (...)
• 19:00
  The Trifecta Study: Comparing Plasma Levels of Donor-derived Cell-Free DNA with the Molecular Phenotype of Kidney Transplant Biopsies - Halloran, P. F., Reeve, J., Madill-Thomsen, K. S., Demko, Z., Prewett, A., Billings, P., the Trifecta Investigators J Am Soc Nephrol
  Background The relationship between the donor-derived cell-free DNA fraction (dd-cfDNA[%]) in plasma in kidney transplant recipients at time of indication biopsy and gene expression in the biopsied allograft has not been defined. Methods In the prospective, multicenter Trifecta study, we (...)
• 19:00
  Mycophenolate Mofetil after Rituximab for Childhood-Onset Complicated Frequently-Relapsing or Steroid-Dependent Nephrotic Syndrome - Iijima, K., Sako, M., Oba, M., Tanaka, S., Hamada, R., Sakai, T., Ohwada, Y., Ninchoji, T., Yamamura, T., Machida, H., Shima, Y., Tanaka, R., Kaito, H., Araki, Y., Morohashi, T., Kumagai, N., Gotoh, Y., Ikezumi, Y., Kubota, T., Kamei, K., Fujita, N., Ohtsuka, Y., Okamoto, T., Yamada, T., Tanaka, E., Shimizu, M., Horinochi, T., Konishi, A., Omori, T., Nakanishi, K., Ishikura, K., Ito, S., Nakamura, H., Nozu, K., on behalf of Japanese Study Group of Kidney Disease in (...) J Am Soc Nephrol
  Background Rituximab is the standard therapy for childhood-onset complicated frequently relapsing or steroid-dependent nephrotic syndrome (FRNS/SDNS). However, most patients redevelop FRNS/SDNS after peripheral B cell recovery. Methods We conducted a multicenter, randomized, double-blind, (...)
• 19:00
  Automated Segmentation of Kidney Cortex and Medulla in CT Images: A Multisite Evaluation Study - Korfiatis, P., Denic, A., Edwards, M. E., Gregory, A. V., Wright, D. E., Mullan, A., Augustine, J., Rule, A. D., Kline, T. L. J Am Soc Nephrol
  Background In kidney transplantation, a contrast CT scan is obtained in the donor candidate to detect subclinical pathology in the kidney. Recent work from the Aging Kidney Anatomy study has characterized kidney, cortex, and medulla volumes using a manual image-processing tool. However, this (...)
• 19:00
  Effect of a 3-Year Lifestyle Intervention in Patients with Chronic Kidney Disease: A Randomized Clinical Trial - Beetham, K. S., Krishnasamy, R., Stanton, T., Sacre, J. W., Douglas, B., Isbel, N. M., Coombes, J. S., Howden, E. J. J Am Soc Nephrol
  Background Supervised lifestyle interventions have the potential to significantly improve physical activity and fitness in patients with CKD. Methods To assess the efficacy of a lifestyle intervention in patients with CKD to improve cardiorespiratory fitness and exercise capacity over 36 (...)
• 19:00
  Management of Adults with Newly Diagnosed Atrial Fibrillation with and without CKD - Bansal, N., Zelnick, L. R., Reynolds, K., Harrison, T. N., Lee, M.-S., Singer, D. E., Sung, S. H., Fan, D., Go, A. S. J Am Soc Nephrol
  Background Atrial fibrillation (AF) is highly prevalent in CKD and is associated with worse cardiovascular and kidney outcomes. Limited data exist on use of AF pharmacotherapies and AF-related procedures by CKD status. We examined a large "real-world" contemporary population with incident AF (...)
• 19:00
  Confirmed Drop in Treatment of Patients with Incident End-Stage Kidney Disease During the Novel Coronavirus Disease 2019 Pandemic - Jacobs, L., Devresse, A., Baudoux, T., Collart, F. J Am Soc Nephrol
• 19:00
  Authors Reply - Wetmore, J. B., Johansen, K. L., Weinhandl, E. D. J Am Soc Nephrol
• 19:00
  Arteritis Status and Renal Involvement in ANCA-Associated Vasculitis - Aendekerk, J. P., Timmermans, S. A. M. E. G., Busch, M. H., van Paassen, P., the Limburg Renal Registry J Am Soc Nephrol
• 19:00
  Authors Reply - Boudhabhay, I., Coutance, G., Karras, A., Duong Van Huyen, J. P. J Am Soc Nephrol

30 December

J Am Soc Nephrol https://jasn.asnjournals.org/

• 19:00
  This Month's Highlights J Am Soc Nephrol
• 19:00
  Genome-wide Admixture Mapping of eGFR and CKD Identify European and African Ancestry-of-Origin Loci in US Hispanics/Latinos - Nestor, J. G., Winkler, C. A. J Am Soc Nephrol
• 19:00
  A Novel Pathological Mechanism of Tertiary Lymphoid Structure Formation in the Renal Pelvis - Yamamoto, S., Yanagita, M. J Am Soc Nephrol
• 19:00
  Disarming the Old Foe. Restoring T-Cell Immune Function with mTor-Inhibitors to Tackle Cytomegalovirus Infection - Bestard, O., Crespo, E. J Am Soc Nephrol
• 19:00
  Nudging Behavioral Economics into Nephrology Care Delivery Research - Wilk, A. S., Tuot, D. S. J Am Soc Nephrol
• 19:00
  We Must all Join the Effort to Dismantle Environmental Racism - Al-Aly, Z. J Am Soc Nephrol
• 19:00
  Regrow or Repair: An Update on Potential Regenerative Therapies for the Kidney - Little, M. H., Humphreys, B. D. J Am Soc Nephrol
  Fifteen years ago, this journal published a review outlining future options for regenerating the kidney. At that time, stem cell populations were being identified in multiple tissues, the concept of stem cell recruitment to a site of injury was of great interest, and the possibility of (...)
• 19:00
  COVID-19 Vaccine Type and Humoral Immune Response in Patients Receiving Dialysis - Garcia, P., Anand, S., Han, J., Montez-Rath, M. E., Sun, S., Shang, T., Parsonnet, J., Chertow, G. M., Schiller, B., Abra, G. J Am Soc Nephrol
• 19:00
  Estimating Nephron Number from Biopsies: Impact on Clinical Studies - Morozov, D., Parvin, N., Conaway, M., Oxley, G., Baldelomar, E. J., Cwiek, A., deRonde, K., Beeman, S. C., Charlton, J. R., Bennett, K. M. J Am Soc Nephrol
  Background Accumulating evidence supports an association between nephron number and susceptibility to kidney disease. However, it is not yet possible to directly measure nephron number in a clinical setting. Recent clinical studies have used glomerular density from a single biopsy and whole (...)
• 19:00
  Real-World Effectiveness and Immunogenicity of BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines in Patients on Hemodialysis - Sibbel, S., McKeon, K., Luo, J., Wendt, K., Walker, A. G., Kelley, T., Lazar, R., Zywno, M. L., Connaire, J. J., Tentori, F., Young, A., Brunelli, S. M. J Am Soc Nephrol
  Background Patients on hemodialysis have an elevated risk for COVID-19 but were not included in efficacy trials of SARS-CoV-2 vaccines. Methods We conducted a retrospective, observational study to estimate the real-world effectiveness and immunogenicity of two mRNA SARS-CoV-2 vaccines in a (...)
• 19:00
  Systematic Review and Meta-Analyses of the Effects of Phosphate-Lowering Agents in Nondialysis CKD - Lioufas, N. M., Pascoe, E. M., Hawley, C. M., Elder, G. J., Badve, S. V., Block, G. A., Johnson, D. W., Toussaint, N. D. J Am Soc Nephrol
  Background Benefits of phosphate-lowering interventions on clinical outcomes in patients with CKD are unclear; systematic reviews have predominantly involved patients on dialysis. This study aimed to summarize evidence from randomized controlled trials (RCTs) concerning benefits and risks of (...)
• 19:00
  Genome-Wide Admixture Mapping of Estimated Glomerular Filtration Rate and Chronic Kidney Disease Identifies European and African Ancestry-of-Origin Loci in Hispanic and Latino Individuals in the United States - Horimoto, A. R. V. R., Xue, D., Cai, J., Lash, J. P., Daviglus, M. L., Franceschini, N., Thornton, T. A. J Am Soc Nephrol
  Background Admixture mapping is a powerful approach for gene mapping of complex traits that leverages the diverse genetic ancestry in populations with recent admixture, such as Hispanic or Latino individuals in the United States. These individuals have an increased risk of CKD. Methods We (...)
• 19:00
  Close Association between Altered Urine-Urothelium Barrier and Tertiary Lymphoid Structure Formation in the Renal Pelvis during Nephritis - Ichii, O., Hosotani, M., Masum, M. A., Horino, T., Otani, Y., Namba, T., Nakamura, T., Hosny Ali, E. Y., Kon, Y. J Am Soc Nephrol
  Background Kidneys with chronic inflammation develop tertiary lymphoid structures (TLSs). Infectious pyelonephritis is characterized by renal pelvis (RP) inflammation. However, the pathologic features of TLSs, including their formation and association with non-infectious nephritis, are (...)
• 19:00
  GWAS in Mice Maps Susceptibility to HIV-Associated Nephropathy to the Ssbp2 Locus - Steers, N. J., Gupta, Y., DAgati, V. D., Lim, T. Y., DeMaria, N., Mo, A., Liang, J., Stevens, K. O., Ahram, D. F., Lam, W. Y., Gagea, M., Nagarajan, L., Sanna-Cherchi, S., Gharavi, A. G. J Am Soc Nephrol
  Background To gain insight into the pathogenesis of collapsing glomerulopathy, a rare form of FSGS that often arises in the setting of viral infections, we performed a genome-wide association study (GWAS) among inbred mouse strains using a murine model of HIV-1 associated nephropathy (HIVAN). (...)
• 19:00
  mTOR Inhibitors Prevent CMV Infection through the Restoration of Functional alphabeta and gammadelta T cells in Kidney Transplantation - Kaminski, H., Marseres, G., Yared, N., Nokin, M.-J., Pitard, V., Zouine, A., Garrigue, I., Loizon, S., Capone, M., Gauthereau, X., Mamani-Matsuda, M., Coueron, R., Duran, R. V., Pinson, B., Pellegrin, I., Thiebaut, R., Couzi, L., Merville, P., Dechanet-Merville, J. J Am Soc Nephrol
  Background The reported association of mTOR-inhibitor (mTORi) treatment with a lower incidence of cytomegalovirus (CMV) infection in kidney transplant recipients (KTR) who are CMV seropositive (R+) remains unexplained. Methods The incidence of CMV infection and T-cell profile was compared (...)
• 19:00
  Super-Resolution Imaging of the Filtration Barrier Suggests a Role for Podocin R229Q in Genetic Predisposition to Glomerular Disease - Butt, L., Unnersjo?-Jess, D., Ho?hne, M., Hahnfeldt, R., Reilly, D., Rinschen, M. M., Plagmann, I., Diefenhardt, P., Bra?hler, S., Brinkko?tter, P. T., Brismar, H., Blom, H., Schermer, B., Benzing, T. J Am Soc Nephrol
  Background Diseases of the kidney’s glomerular filtration barrier are a leading cause of end stage renal failure. Despite a growing understanding of genes involved in glomerular disorders in children, the vast majority of adult patients lack a clear genetic diagnosis. The protein podocin (...)
• 19:00
  Three-Dimensional Visualization of the Podocyte Actin Network Using Integrated Membrane Extraction, Electron Microscopy, and Machine Learning - Qu, C., Roth, R., Puapatanakul, P., Loitman, C., Hammad, D., Genin, G. M., Miner, J. H., Suleiman, H. Y. J Am Soc Nephrol
  Background Actin stress fibers are abundant in cultured cells, but little is known about them in vivo. In podocytes, much evidence suggests that mechanobiologic mechanisms underlie podocyte shape and adhesion in health and in injury, with structural changes to actin stress fibers potentially (...)
• 19:00
  Effect of Nudge-Based Intervention on Adherence to Physician Visit Recommendations and Early Health Outcomes among Individuals Identified with Chronic Kidney Disease in Screens - Fukuma, S., Sasaki, S., Taguri, M., Goto, R., Misumi, T., Saigusa, Y., Tsugawa, Y. J Am Soc Nephrol
  Background Although CKD screening programs have been provided in many settings, little is known as to how we can effectively translate those screening programs into improved health. Methods We conducted a randomized clinical trial on national health screening for CKD in Japan between April (...)
• 19:00
  Advanced Tertiary Lymphoid Tissues in Protocol Biopsies are Associated with Progressive Graft Dysfunction in Kidney Transplant Recipients - Lee, Y. H., Sato, Y., Saito, M., Fukuma, S., Saito, M., Yamamoto, S., Komatsuda, A., Fujiyama, N., Satoh, S., Lee, S.-H., Boor, P., Habuchi, T., Floege, J., Yanagita, M. J Am Soc Nephrol
  Background Tertiary lymphoid tissues (TLTs) are ectopic lymphoid tissues found in chronically inflamed organs. Although studies have documented TLT formation in transplanted kidneys, the clinical relevance of these TLTs remains controversial. We examined the effects of TLTs on future graft (...)
• 19:00
  Activation of the Calcium Receptor by Calcimimetic Agents Is Preserved Despite Modest Attenuating Effects of Hyperphosphatemia - Goodman, W. G., Ward, D. T., Martin, K. J., Drayer, D., Moore, C., Xu, J., Lai, J., Chon, Y., Nemeth, E. F. J Am Soc Nephrol
  Background Phosphorus levels in the range seen clinically among patients undergoing dialysis have been reported to attenuate calcium receptor activation and modify parathyroid hormone (PTH) release from isolated parathyroid glands in vitro. Some clinicians and providers of dialysis thus have (...)
• 19:00
  Alpha Globin Gene Copy Number Is Associated with Prevalent Chronic Kidney Disease and Incident End-Stage Kidney Disease among Black Americans - Ruhl, A. P., Jeffries, N., Yang, Y., Naik, R. P., Patki, A., Pecker, L. H., Mott, B. T., Zakai, N. A., Winkler, C. A., Kopp, J. B., Lange, L. A., Irvin, M. R., Gutierrez, O. M., Cushman, M., Ackerman, H. C. J Am Soc Nephrol
  Background α-Globin is expressed in endothelial cells of resistance arteries, where it limits endothelial nitric oxide signaling and enhances α-adrenergic–mediated vasoconstriction. α-Globin gene (HBA) copy number is variable in people of African descent and other populations (...)
• 19:00
  Hyperkalemia Risk with Finerenone: Results from the FIDELIO-DKD Trial - Agarwal, R., Joseph, A., Anker, S. D., Filippatos, G., Rossing, P., Ruilope, L. M., Pitt, B., Kolkhof, P., Scott, C., Lawatscheck, R., Wilson, D. J., Bakris, G. L., on behalf of the FIDELIO-DKD Investigators J Am Soc Nephrol
  Background Finerenone reduced risk of cardiorenal outcomes in patients with CKD and type 2 diabetes in the FIDELIO-DKD trial. We report incidences and risk factors for hyperkalemia with finerenone and placebo in FIDELIO-DKD. Methods This post hoc safety analysis defined hyperkalemia as (...)
• 19:00
  Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology - Watts, A. J. B., Keller, K. H., Lerner, G., Rosales, I., Collins, A. B., Sekulic, M., Waikar, S. S., Chandraker, A., Riella, L. V., Alexander, M. P., Troost, J. P., Chen, J., Fermin, D., Yee, J. L., Sampson, M. G., Beck, L. H., Henderson, J. M., Greka, A., Rennke, H. G., Weins, A. J Am Soc Nephrol
  Background Failure of the glomerular filtration barrier, primarily by loss of slit diaphragm architecture, underlies nephrotic syndrome in minimal change disease. The etiology remains unknown. The efficacy of B cell–targeted therapies in some patients, together with the known proteinuric effect (...)
• 19:00
  Correction: Manipulation of Nephron-Patterning Signals Enables Selective Induction of Podocytes from Human Pluripotent Stem Cells J Am Soc Nephrol

30 November

J Am Soc Nephrol https://jasn.asnjournals.org/

• 15:14
  CRISPR/Cas9-Engineered HLA-Deleted Glomerular Endothelial Cells as a Tool to Predict Pathogenic Non-HLA Antibodies in Kidney Transplant Recipients - Lamarthee, B., Burger, C., Leclaire, C., Lebraud, E., Zablocki, A., Morin, L., Lebreton, X., Charreau, B., Snanoudj, R., Charbonnier, S., Blein, T., Hardy, M., Zuber, J., Satchell, S., Gallazzini, M., Terzi, F., Legendre, C., Taupin, J. L., Rabant, M., Tinel, C., Anglicheau, D. J Am Soc Nephrol
  Background After kidney transplantation, donor-specific antibodies against human leukocyte antigen donor-specific antibodies (HLA-DSAs) drive antibody-mediated rejection (ABMR) and are associated with poor transplant outcomes. However, ABMR histology (ABMRh) is increasingly reported in kidney (...)
• 15:14
  Conversion from Calcineurin Inhibitor- to Belatacept-Based Maintenance Immunosuppression in Renal Transplant Recipients: A Randomized Phase 3b Trial - Budde, K., Prashar, R., Haller, H., Rial, M. C., Kamar, N., Agarwal, A., de Fijter, J. W., Rostaing, L., Berger, S. P., Djamali, A., Leca, N., Allamassey, L., Gao, S., Polinsky, M., Vincenti, F. J Am Soc Nephrol
  Background Calcineurin inhibitors (CNIs) are standard of care after kidney transplantation, but they are associated with nephrotoxicity and reduced long-term graft survival. Belatacept, a selective T cell costimulation blocker, is approved for the prophylaxis of kidney transplant rejection. (...)
• 15:14
  This Month's Highlights J Am Soc Nephrol
• 15:14
  COVID-19 Vaccination in Kidney Transplant Recipients: An Ounce Pre-Transplant is Worth a Pound Post-Transplant - Chandran, S., Stock, P. G. J Am Soc Nephrol
• 15:14
  Making the Connection - Oxburgh, L. J Am Soc Nephrol
• 15:14
  Back to the Future: The Role of Metabolic Studies in Therapeutic Advances - Milliner, D. S., Lieske, J. C. J Am Soc Nephrol
• 15:14
  IgA Nephropathy Needs a Diagnostic Marker of Immunologic Activity to Select the Right Patients for Immunotherapies - Hilhorst, M., Anders, H.-J. J Am Soc Nephrol
• 15:14
  It Is Time for Patient-Reported Outcome Measures to Be Included in the Approval Process for Solid Organ Transplant Medications - Formica, R. N., Turgeon, N. J Am Soc Nephrol
• 15:14
  Removing Race from Kidney Disease Diagnosis - Quaggin, S. E., Palevsky, P. M. J Am Soc Nephrol
• 15:14
  Global Health Education in Nephrology: The Time has Come - Ingenhoff, R., Brewster, U., Rastegar, A., Kalyesubula, R., Knauf, F. J Am Soc Nephrol
• 15:14
  A Unifying Approach for GFR Estimation: Recommendations of the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease - Delgado, C., Baweja, M., Crews, D. C., Eneanya, N. D., Gadegbeku, C. A., Inker, L. A., Mendu, M. L., Miller, W. G., Moxey-Mims, M. M., Roberts, G. V., St. Peter, W. L., Warfield, C., Powe, N. R. J Am Soc Nephrol
  Background In response to a national call for re-evaluation of the use of race in clinical algorithms, the National Kidney Foundation (NKF) and the American Society of Nephrology (ASN) established a Task Force to reassess inclusion of race in the estimation of GFR in the United States and its (...)
• 15:14
  Patient Activation Measure in Dialysis-Dependent Patients in the United States - Cukor, D., Zelnick, L. R., Charytan, D. M., Shallcross, A. J., Mehrotra, R. J Am Soc Nephrol
• 15:14
  Second Wave Antibodies in Autoimmune Renal Diseases: The Case of Lupus Nephritis - Angeletti, A., Bruschi, M., Moroni, G., Sinico, R. A., Franceschini, F., Fredi, M., Vaglio, A., Cavagna, L., Petretto, A., Pratesi, F., Migliorini, P., Locatelli, F., Pazzola, G., Pesce, G., Bagnasco, M., Manfredi, A., Ramirez, G. A., Esposito, P., Murdaca, G., Negrini, S., Cipriani, L., Trezzi, B., Emmi, G., Cavazzana, I., Binda, V., dAlessandro, M., Fenaroli, P., Pisani, I., Garibotto, G., Montecucco, C., Santoro, D., Scolari, F., Volpi, S., Mosca, M., Tincani, A., Candiano, G., Prunotto, M., Verrina, E., Ravelli, A., Ghiggeri, G. (...) J Am Soc Nephrol
  Clinical Trial registry name and registration number: Zeus study, NCT02403115
• 15:14
  Use of a Smartphone Camera at the Bedside to Assess Adequacy of Kidney Biopsies - Singh, G., Massak, M., Czaplicki, M., Young, E., Sharma, S., Chang, A., Bhanushali, A., Anand, P. J Am Soc Nephrol
• 15:14
  B and T Cell Responses after a Third Dose of SARS-CoV-2 Vaccine in Kidney Transplant Recipients - Schrezenmeier, E., Rincon-Arevalo, H., Stefanski, A.-L., Potekhin, A., Staub-Hohenbleicher, H., Choi, M., Bachmann, F., Pross, V., Hammett, C., Schrezenmeier, H., Ludwig, C., Jahrsdo?rfer, B., Lino, A. C., Eckardt, K.-U., Kotsch, K., Do?rner, T., Budde, K., Sattler, A., Halleck, F. J Am Soc Nephrol
  Background Accumulating evidence sugges ts solid organ transplant recipients, as opposed to the general population, show strongly impaired responsiveness toward standard SARS-CoV-2 mRNA-based vaccination, demanding alternative strategies for protectio n o f this vulnerable group. Methods In (...)
• 15:14
  Generation of Distal Renal Segments Involves a Unique Population of Aqp2+ Progenitor Cells - Gao, C., Chen, L., Chen, E., Tsilosani, A., Xia, Y., Zhang, W. J Am Soc Nephrol
  Background Progenitor cells have clonogenicity, self-renewal, and multipotential capacity, and they can generate multiple types of cells during development. Evidence demonstrating the existence of such progenitor cells for renal distal segments is lacking. Methods To identify Aqp2+ progenitor (...)
• 15:14
  Physiologic Regulation of Systemic Klotho Levels by Renal CaSR Signaling in Response to CaSR Ligands and pHo - Yoon, J., Liu, Z., Lee, E., Liu, L., Ferre, S., Pastor, J., Zhang, J., Moe, O. W., Chang, A. N., Miller, R. T. J Am Soc Nephrol
  Background The kidney is the source of sKlotho and kidney-specific loss of Klotho leads to a phenotype resembling the premature multiorgan failure phenotype in Klotho-hypomorphic mice (kl/kl mice). Klotho and the Ca-sensing receptor (CaSR) are highly expressed in the distal convoluted tubule (...)
• 15:14
  CHOP-ASO Ameliorates Glomerular and Tubular Damage on Top of ACE Inhibition in Diabetic Kidney Disease - Shahzad, K., Fatima, S., Al-Dabet, M. M., Gadi, I., Khawaja, H., Ambreen, S., Elwakiel, A., Klo?ting, N., Blu?her, M., Nawroth, P. P., Mertens, P. R., Michel, S., Jaschinski, F., Klar, R., Isermann, B. J Am Soc Nephrol
  Background Maladaptive endoplasmic reticulum stress signaling in diabetic kidney disease (DKD) is linked to increased glomerular and tubular expression of the cell-death–promoting transcription factor C/EBP homologous protein (CHOP). Here, we determined whether locked nucleic acid (...)
• 15:14
  IL-17 Receptor C Signaling Controls CD4+ TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases - Schmidt, T., Luebbe, J., Kilian, C., Riedel, J.-H., Hiekmann, S., Asada, N., Ginsberg, P., Robben, L., Song, N., Kaffke, A., Peters, A., Borchers, A., Flavell, R. A., Gagliani, N., Pelzcar, P., Huber, S., Huber, T. B., Turner, J.-E., Paust, H.-J., Krebs, C. F., Panzer, U. J Am Soc Nephrol
  Background IL-17A–producing CD4+ T helper (TH17) cells play a critical role in autoimmune and chronic inflammatory diseases, such as crescentic GN. The proinflammatory effects of IL-17 are mediated by the activation of the IL-17RA/IL-17RC complex. Although the expression of these receptors on (...)
• 15:14
  Heterozygous Mutation of Vegfr3 Reduces Renal Lymphatics without Renal Dysfunction - Liu, H., Hiremath, C., Patterson, Q., Vora, S., Shang, Z., Jamieson, A. R., Fiolka, R., Dean, K. M., Dellinger, M. T., Marciano, D. K. J Am Soc Nephrol
  Background Lymphatic abnormalities are observed in several types of kidney disease, but the relationship between the renal lymphatic system and renal function is unclear. The discovery of lymphatic-specific proteins, advances in microscopy, and available genetic mouse models provide the tools (...)
• 15:14
  Detection of PKD1 and PKD2 Somatic Variants in Autosomal Dominant Polycystic Kidney Cyst Epithelial Cells by Whole-Genome Sequencing - Zhang, Z., Bai, H., Blumenfeld, J., Ramnauth, A. B., Barash, I., Prince, M., Tan, A. Y., Michaeel, A., Liu, G., Chicos, I., Rennert, L., Giannakopoulos, S., Larbi, K., Hughes, S., Salvatore, S. P., Robinson, B. D., Kapur, S., Rennert, H. J Am Soc Nephrol
  Background Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the development of multiple cysts in the kidneys. It is often caused by pathogenic mutations in PKD1 and PKD2 genes that encode polycystin proteins. Although the molecular mechanisms for (...)
• 15:14
  Activation of the Hypoxia-Inducible Factor Pathway Inhibits Epithelial Sodium Channel-Mediated Sodium Transport in Collecting Duct Principal Cells - Dizin, E., Olivier, V., Roth, I., Sassi, A., Arnoux, G., Ramakrishnan, S., Morel, S., Kwak, B. R., Loffing, J., Hummler, E., Wenger, R. H., Frew, I. J., Feraille, E. J Am Soc Nephrol
  Background Active sodium reabsorption is the major factor influencing renal oxygen consumption and production of reactive oxygen species (ROS). Increased sodium reabsorption uses more oxygen, which may worsen medullary hypoxia and produce more ROS via enhanced mitochondrial ATP synthesis. Both (...)
• 15:14
  Guanidinylated Apolipoprotein C3 (ApoC3) Associates with Kidney and Vascular Injury - Schunk, S. J., Hermann, J., Sarakpi, T., Triem, S., Lellig, M., Hahm, E., Zewinger, S., Schmit, D., Becker, E., Mo?llmann, J., Lehrke, M., Kramann, R., Boor, P., Lipp, P., Laufs, U., Ma?rz, W., Reiser, J., Jankowski, J., Fliser, D., Speer, T., Jankowski, V. J Am Soc Nephrol
  Background Coexistent CKD and cardiovascular diseases are highly prevalent in Western populations and account for substantial mortality. We recently found that apolipoprotein C-3 (ApoC3), a major constituent of triglyceride-rich lipoproteins, induces sterile systemic inflammation by activating (...)
• 15:14
  Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases - Yu, Z., Jin, J., Tin, A., Ko?ttgen, A., Yu, B., Chen, J., Surapaneni, A., Zhou, L., Ballantyne, C. M., Hoogeveen, R. C., Arking, D. E., Chatterjee, N., Grams, M. E., Coresh, J. J Am Soc Nephrol
  Background Genome-wide association studies (GWAS) have revealed numerous loci for kidney function (eGFR). The relationship between polygenic predictors of eGFR, risk of incident adverse kidney outcomes, and the plasma proteome is not known. Methods We developed a genome-wide polygenic risk (...)
• 15:14
  Endogenous Oxalate Production in Primary Hyperoxaluria Type 1 Patients - Garrelfs, S. F., van Harskamp, D., Peters-Sengers, H., van den Akker, C. H. P., Wanders, R. J. A., Wijburg, F. A., van Goudoever, J. B., Groothoff, J. W., Schierbeek, H., Oosterveld, M. J. S. J Am Soc Nephrol
  Background Primary hyperoxaluria type 1 (PH1) is an inborn error of glyoxylate metabolism, characterized by increased endogenous oxalate production. The metabolic pathways underlying oxalate synthesis have not been fully elucidated, and upcoming therapies require more reliable outcome (...)
• 15:14
  Intensity of Macrophage Infiltration in Glomeruli Predicts Response to Immunosuppressive Therapy in Patients with IgA Nephropathy - Xie, D., Zhao, H., Xu, X., Zhou, Z., Su, C., Jia, N., Liu, Y., Hou, F. F. J Am Soc Nephrol
  Background The lack of a tool for predicting the response to immunosuppressive therapy in IgA nephropathy (IgAN) limits patient-specific risk stratification and early treatment decision making. Models for predicting response to immunosuppression in IgAN that can be applied at the time of (...)
• 15:14
  Effect of Low-Dose Methotrexate on eGFR and Kidney Adverse Events: A Randomized Clinical Trial - Sparks, J. A., Vanni, K. M. M., Sparks, M. A., Xu, C., Santacroce, L. M., Glynn, R. J., Ridker, P. M., Solomon, D. H. J Am Soc Nephrol
  Background Low-dose methotrexate (LD-MTX) is contraindicated in advanced CKD, but kidney safety in normal kidney function or mild-to-moderate CKD is less clear. Methods We performed a secondary analysis for eGFR and kidney AEs using the randomized double-blind, placebo-controlled (...)
• 15:14
  Predictors and Dynamics of the Humoral and Cellular Immune Response to SARS-CoV-2 mRNA Vaccines in Hemodialysis Patients: A Multicenter Observational Study - Van Praet, J., Reynders, M., De Bacquer, D., Viaene, L., Schoutteten, M. K., Caluwe, R., Doubel, P., Heylen, L., De Bel, A. V., Van Vlem, B., Steensels, D., De Vriese, A. S. J Am Soc Nephrol
  Background Preliminary evidence suggests patients on hemodialysis have a blunted early serological response to SARS-CoV-2 vaccination. Optimizing the vaccination strategy in this population requires a thorough understanding of predictors and dynamics of humoral and cellular immune responses to (...)
• 15:14
  Delayed Kinetics of IgG, but Not IgA, Antispike Antibodies in Transplant Recipients following SARS-CoV-2 Infection - Cravedi, P., Ahearn, P., Wang, L., Yalamarti, T., Hartzell, S., Azzi, Y., Menon, M. C., Jain, A., Billah, M., Fernandez-Vina, M., Gebel, H. M., Woodle, E. S., Haddad, N. S., Morrison-Porter, A., Lee, F. E.-H., Sanz, I., Akalin, E., Girnita, A., Maltzman, J. S. J Am Soc Nephrol
  Background Kidney transplant recipients are at increased risk of severe outcomes during COVID-19. Antibodies against the virus are thought to offer protection, but a thorough characterization of anti–SARS-CoV-2 immune globulin isotypes in kidney transplant recipients following SARS-CoV-2 (...)

29 October

J Am Soc Nephrol https://jasn.asnjournals.org/

• 21:45
  Indoleamine 2,3-dioxygenase-1, a Novel Therapeutic Target for Post-Vascular Injury Thrombosis in CKD - Walker, J. A., Richards, S., Whelan, S. A., Yoo, S. B., Russell, T. L., Arinze, N., Lotfollahzadeh, S., Napoleon, M. A., Belghasem, M., Lee, N., Dember, L. M., Ravid, K., Chitalia, V. C. J Am Soc Nephrol
  Background CKD, characterized by retained uremic solutes, is a strong and independent risk factor for thrombosis after vascular procedures. Uremic solutes such as indoxyl sulfate (IS) and kynurenine (Kyn) mediate prothrombotic effect through tissue factor (TF). IS and Kyn biogenesis depends on (...)
• 21:45
  This Month's Highlights J Am Soc Nephrol
• 21:45
  Tribute to Barbara T. Murphy - Quaggin, S. E., Gill, J. S. J Am Soc Nephrol
• 21:45
  Beyond Transcription Factors: Remodeling Chromatin in the Metanephric Mesenchyme - El-Dahr, S. S. J Am Soc Nephrol
• 21:45
  Predictive Enrichment in Kidney RCTs: Is Albuminuria the Answer? - Odutayo, A., Cherney, D. Z. I. J Am Soc Nephrol
• 21:45
  Understanding Risks and Our Responsibility to Living Donors - Gill, J. S., Schold, J., Kaplan, B. J Am Soc Nephrol
• 21:45
  The Art and Science of Medicine ... and Standardized Test Scores - Quaggin, S. E., Safar-Boueri, L. J Am Soc Nephrol
• 21:45
  Podocyte Aging: Why and How Getting Old Matters - Shankland, S. J., Wang, Y., Shaw, A. S., Vaughan, J. C., Pippin, J. W., Wessely, O. J Am Soc Nephrol
  The effects of healthy aging on the kidney, and how these effects intersect with superimposed diseases, are highly relevant in the context of the population’s increasing longevity. Age-associated changes to podocytes, which are terminally differentiated glomerular epithelial cells, adversely (...)
• 21:45
  Analysis of Performance Trends from 2010-2019 on the American Board of Internal Medicine Nephrology Certifying Exam - Berns, J. S., Weng, W., Jaar, B. G., Lipner, R. S., Brossman, B. G., McDonald, F. S. J Am Soc Nephrol
  Background The pass rate on the American Board of Internal Medicine (ABIM) nephrology certifying exam has declined and is among the lowest of all internal medicine (IM) subspecialties. In recent years, there have also been fewer applicants for the nephrology fellowship match. Methods This (...)
• 21:45
  Impaired Humoral but Substantial Cellular Immune Response to Variants of Concern B1.1.7 and B.1.351 in Hemodialysis Patients after Vaccination with BNT162b2 - Thieme, C. J., Blazquez-Navarro, A., Safi, L., Kaliszczyk, S., Paniskaki, K., Neumann, I. E., Schmidt, K., Stockhausen, M., Ho?rstrup, J., Cinkilic, O., Flitsch-Kiefner, L., Meister, T. L., Marheinecke, C., Pfaender, S., Steinmann, E., Seibert, F. S., Stervbo, U., Westhoff, T. H., Roch, T., Babel, N. J Am Soc Nephrol
• 21:45
  Testing of Worn Face Masks for Timely Diagnosis of SARS-CoV-2 in Hemodialysis Patients - Wang, X., Grobe, N., Haq, Z., Thwin, O., Fuentes, L. R., Maddux, D., Kotanko, P. J Am Soc Nephrol
• 21:45
  Large Between-Patient Variability in eGFR Decline before Clinical Trial Enrollment and Impact on Atrasentans Efficacy: A Post Hoc Analysis from the SONAR Trial - Waijer, S. W., de Vries, S. T., Busch, R., Xie, D., Gansevoort, R. T., Hou, F. F., Gorriz, J. L., Laverman, G. D., De Nicola, L., Pascual, J., Provenzano, M., Pergola, P. E., Tang, S. C. W., Wanner, C., Zaoui, P., Parving, H.-H., de Zeeuw, D., Heerspink, H. J. L. J Am Soc Nephrol
• 21:45
  Immunogenicity of SARS-CoV-2 Vaccine in Dialysis - Lacson, E., Argyropoulos, C. P., Manley, H. J., Aweh, G., Chin, A. I., Salman, L. H., Hsu, C. M., Johnson, D. S., Weiner, D. E. J Am Soc Nephrol
  Background Patients receiving maintenance dialysis represent a high-risk, immune-compromised population with 15%–25% COVID-19 mortality rate who were unrepresented in clinical trials of mRNA vaccines. Methods All patients receiving maintenance dialysis who received two doses of SARS-CoV-2 mRNA (...)
• 21:45
  Donor-Specific Antibody Is Associated with Increased Expression of Rejection Transcripts in Renal Transplant Biopsies Classified as No Rejection - Madill-Thomsen, K. S., Bo?hmig, G. A., Bromberg, J., Einecke, G., Eskandary, F., Gupta, G., Hidalgo, L. G., Myslak, M., Viklicky, O., Perkowska-Ptasinska, A., Halloran, P. F., the INTERCOMEX Investigators, Mannon, Seron, Sellares, Akalin, de Freitas, Picton, Bromberg, Weir, Budde, Heinbokel, Einecke, Yang, Narins, Samaniego-Picota, Lefaucheur, Loupy, Myslak, Perkowska-Ptasinska, Bingaman, Brennan, Malone, Kasiske, Halloran, Matas, Djamali, Bo?hmig, Eskandary, (...) J Am Soc Nephrol
  Background Donor -specific HLA antibody (DSA) is present in many kidney transplant patients whose biopsies are classified as no rejection (NR). We explored whether in some NR kidneys DSA has subtle effects not currently being recognized. Methods We used microarrays to examine the relationship (...)
• 21:45
  Ferroptosis Promotes Cyst Growth in Autosomal Dominant Polycystic Kidney Disease Mouse Models - Zhang, X., Li, L. X., Ding, H., Torres, V. E., Yu, C., Li, X. J Am Soc Nephrol
  Background Autosomal dominant polycystic kidney disease (ADPKD), the most common inherited kidney disease, is regulated by different forms of cell death, including apoptosis and autophagy. However, the role in ADPKD of ferroptosis, a recently discovered form of cell death mediated by iron and (...)
• 21:45
  Glomerular Endothelial Cell-Derived microRNA-192 Regulates Nephronectin Expression in Idiopathic Membranous Glomerulonephritis - Mu?ller-Deile, J., Sopel, N., Ohs, A., Rose, V., Gro?ner, M., Wrede, C., Hegermann, J., Daniel, C., Amann, K., Zahner, G., Schiffer, M. J Am Soc Nephrol
  Background Autoantibodies binding to podocyte antigens cause idiopathic membranous glomerulonephritis (iMGN). However, it remains elusive how autoantibodies reach the subepithelial space because the glomerular filtration barrier (GFB) is size selective and almost impermeable for antibodies. (...)
• 21:45
  PodoSighter: A Cloud-Based Tool for Label-Free Podocyte Detection in Kidney Whole-Slide Images - Govind, D., Becker, J. U., Miecznikowski, J., Rosenberg, A. Z., Dang, J., Tharaux, P. L., Yacoub, R., Thaiss, F., Hoyer, P. F., Manthey, D., Lutnick, B., Worral, A. M., Mohammad, I., Walavalkar, V., Tomaszewski, J. E., Jen, K.-Y., Sarder, P. J Am Soc Nephrol
  Background Podocyte depletion precedes progressive glomerular damage in several kidney diseases. However, the current standard of visual detection and quantification of podocyte nuclei from brightfield microscopy images is laborious and imprecise. Methods We have developed PodoSighter, an (...)
• 21:45
  Chromatin Remodelers Interact with Eya1 and Six2 to Target Enhancers to Control Nephron Progenitor Cell Maintenance - Li, J., Xu, J., Jiang, H., Zhang, T., Ramakrishnan, A., Shen, L., Xu, P.-X. J Am Soc Nephrol
  Background Eya1 is a critical regulator of nephron progenitor cell specification and interacts with Six2 to promote NPC self-renewal. Haploinsufficiency of these genes causes kidney hypoplasia. However, how the Eya1-centered network operates remains unknown. Methods We engineered a (...)
• 21:45
  Kidney Outcomes in Long COVID - Bowe, B., Xie, Y., Xu, E., Al-Aly, Z. J Am Soc Nephrol
  Background COVID-19 is associated with increased risk of post-acute sequelae involving pulmonary and extrapulmonary organ systems—referred to as long COVID. However, a detailed assessment of kidney outcomes in long COVID is not yet available. Methods We built a cohort of 1,726,683 US Veterans (...)
• 21:45
  Renal Histologic Analysis Provides Complementary Information to Kidney Function Measurement for Patients with Early Diabetic or Hypertensive Disease - Quinn, G. Z., Abedini, A., Liu, H., Ma, Z., Cucchiara, A., Havasi, A., Hill, J., Palmer, M. B., Susztak, K. J Am Soc Nephrol
  Background Patients with diabetic or hypertensive kidney disease rarely undergo kidney biopsy because nephrologists commonly believe that biopsy-related risk outweighs the potential benefits of obtaining histologic information to guide clinical decisions. Although kidney function is acutely (...)
• 21:45
  Impaired Tubular Secretion of Organic Solutes in Advanced Chronic Kidney Disease - Mair, R. D., Lee, S., Plummer, N. S., Sirich, T. L., Meyer, T. W. J Am Soc Nephrol
  Background The clearance of solutes removed by tubular secretion may be altered out of proportion to the GFR in CKD. Recent studies have described considerable variability in the secretory clearance of waste solutes relative to the GFR in patients with CKD. Methods To test the hypothesis that (...)
• 21:45
  mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy - Schlingmann, K. P., Jouret, F., Shen, K., Nigam, A., Arjona, F. J., Dafinger, C., Houillier, P., Jones, D. P., Kleineru?schkamp, F., Oh, J., Godefroid, N., Eltan, M., Gu?ran, T., Burtey, S., Parotte, M.-C., Ko?nig, J., Braun, A., Bos, C., Ibars Serra, M., Rehmann, H., Zwartkruis, F. J. T., Renkema, K. Y., Klingel, K., Schulze-Bahr, E., Schermer, B., Bergmann, C., Altmu?ller, J., Thiele, H., Beck, B. B., Dahan, K., Sabatini, D., Liebau, M. C., Vargas-Poussou, R., Knoers, N. V. A. M., Konrad, M., de Baaij, J. H. (...) J Am Soc Nephrol
  Background Over the last decade, advances in genetic techniques have resulted in the identification of rare hereditary disorders of renal magnesium and salt handling. Nevertheless, approximately 20% of all patients with tubulopathy lack a genetic diagnosis. Methods We performed whole-exome (...)
• 21:45
  Early Response in Albuminuria and Long-Term Kidney Protection during Treatment with an Endothelin Receptor Antagonist: A Prespecified Analysis from the SONAR Trial - Heerspink, H. J. L., Xie, D., Bakris, G., Correa-Rotter, R., Hou, F.-F., Kitzman, D. W., Kohan, D., Makino, H., McMurray, J. J. V., Perkovic, V., Rossing, P., Parving, H.-H., de Zeeuw, D., on behalf on the SONAR Investigators J Am Soc Nephrol
  Background Whether early reduction in albuminuria with atrasentan treatment predicts its long-term kidney-protective effect is unknown. Methods To assess the long-term effects on kidney outcomes of atrasentan versus placebo in the SONAR trial, we enrolled patients who had type 2 diabetes and (...)
• 21:45
  Preserved Cerebral Oxygenation with Worsening Global Myocardial Strain during Pediatric Chronic Hemodialysis - Idrovo, A., Pignatelli, R., Loar, R., Nieuwsma, A., Geer, J., Solomon, C., Swartz, S., Ghanayem, N., Akcan-Arikan, A., Srivaths, P. J Am Soc Nephrol
  Background Cerebral and myocardial hypoperfusion occur during hemodialysis in adults. Pediatric patients receiving chronic hemodialysis have fewer cardiovascular risk factors, yet cardiovascular morbidity remains prominent. Methods We conducted a prospective observational study of pediatric (...)
• 21:45
  The Clinical Application of Urine Soluble CD163 in ANCA-Associated Vasculitis - Moran, S. M., Scott, J., Clarkson, M. R., Conlon, N., Dunne, J., Griffin, M. D., Griffin, T. P., Groarke, E., Holian, J., Judge, C., Wyse, J., McLoughlin, K., OHara, P. V., Kretzler, M., Little, M. A., Nephrotic Syndrome Study Network (NEPTUNE), Sedor, Dell, Schachere, Negrey, Lemley, Lim, Srivastava, Garrett, Sethna, Laurent, Appel, Toledo, Greenbaum, Wang, Kang, Adler, LaPage, Athavale, Itteera, Atkinson, Boynton, Fervenza, Lieske, Hogan, Chernitskiy, Kaskel, Ross, Flynn, Kopp, Blake, Trachtman, Zhdanova, Modersitzki, Vento, Lafayette, Mehta, Gadegbeku, Quinn-Boyle, Hladunewich, Reich, (...) J Am Soc Nephrol
  Background Up to 70% of patients with ANCA-associated vasculitis (AAV) develop GN, with 26% progressing to ESKD. Diagnostic-grade and noninvasive tools to detect active renal inflammation are needed. Urinary soluble CD163 (usCD163) is a promising biomarker of active renal vasculitis, but a (...)
• 21:45
  Intermediate Renal Outcomes, Kidney Failure, and Mortality in Obese Kidney Donors - Ibrahim, H. N., Murad, D. N., Hebert, S. A., Adrogue, H. E., Nguyen, H., Nguyen, D. T., Matas, A. J., Graviss, E. A. J Am Soc Nephrol
  Background Obesity is associated with the two archetypal kidney disease risk factors: hypertension and diabetes. Concerns that the effects of diabetes and hypertension in obese kidney donors might be magnified in their remaining kidney have led to the exclusion of many obese candidates from (...)
• 21:45
  Changes in Treatment of Patients with Incident ESKD during the Novel Coronavirus Disease 2019 Pandemic - Wetmore, J. B., Johansen, K. L., Liu, J., Peng, Y., Gilbertson, D. T., Weinhandl, E. D. J Am Soc Nephrol
  Background The COVID-19 pandemic caused major disruptions to care for patients with advanced CKD. Methods We investigated the incidence of documented ESKD, ESKD treatment modalities, changes in eGFR at dialysis initiation, and use of incident central venous catheters (CVCs) by epidemiologic (...)
• 21:45
  Longitudinal Outcomes of COVID-19-Associated Collapsing Glomerulopathy and Other Podocytopathies - Kudose, S., Santoriello, D., Bomback, A. S., Sekulic, M., Batal, I., Stokes, M. B., Ghavami, I. A., Kim, J. S., Marasa, M., Xu, K., Peleg, Y., Barasch, J., Canetta, P., Rasouly, H. M., Gharavi, A. G., Markowitz, G. S., DAgati, V. D. J Am Soc Nephrol
  Background The long-term outcome of COVID-19–associated collapsing glomerulopathy is unknown. Methods We retrospectively identified 76 native kidney biopsies from patients with history of COVID-19 between March 2020 and April 2021. Presenting and outcome data were obtained for all 23 patients (...)
• 21:45
  Heterogenous Role of IRF4 in Kidney Fibrosis - Liu, Z., Zhang, J. J Am Soc Nephrol
• 21:45
  Need for a Validation Study before Using the Two-Step Algorithm for dd-cfDNA to Screen for Acute Rejection - Gupta, A., Kaplan, B. J Am Soc Nephrol
• 21:45
  Authors Reply - Harris, R. C., Zhang, M.-Z. J Am Soc Nephrol
• 21:45
  Authors Reply - Bunnapradist, S., Tabriziani, H. J Am Soc Nephrol
• 21:45
  Incidence of Arteritis and Peritubular Capillaritis in ANCA-associated Vasculitis - Hakroush, S., Tampe, B. J Am Soc Nephrol

1 October

J Am Soc Nephrol https://jasn.asnjournals.org/

• 19:51
  This Month's Highlights J Am Soc Nephrol
• 19:51
  Renal Nerve Ablation in Nephritis and Beyond - Rodionova, K., Ditting, T., Veelken, R. J Am Soc Nephrol
• 19:51
  Considerations in the Study of Body Mass Index Variability - Gregg, L. P., Navaneethan, S. D. J Am Soc Nephrol
• 19:51
  Coding Variants in Susceptibility to Diabetic Kidney Disease - Liu, L., Kiryluk, K. J Am Soc Nephrol
• 19:51
  Mendelian Randomization Analysis as a Tool to Gain Insights into Causes of Diseases: A Primer - Tin, A., Ko?ttgen, A. J Am Soc Nephrol
  Many Mendelian randomization (MR) studies have been published recently, with inferences on the causal relationships between risk factors and diseases that have potential implications for clinical research. In nephrology, MR methods have been applied to investigate potential causal relationships (...)
• 19:51
  Acquired Decline in Ultrafiltration in Peritoneal Dialysis: The Role of Glucose - Krediet, R. T. J Am Soc Nephrol
  Ultrafiltration is essential in peritoneal dialysis (PD) for maintenance of euvolemia, making ultrafiltration insufficiency—preferably called ultrafiltration failure—an important complication. The mechanisms of ultrafiltration and ultrafiltration failure are more complex than generally assumed, (...)
• 19:51
  Introducing a Special Series: Addressing Racial and Ethnic Disparities in Kidney Disease - Briggs, J. P., Wesson, D. J Am Soc Nephrol
• 19:51
  Racial Inequalities in Drinking Water Lead Exposure: A Wake-Up Call to Protect Patients with End Stage Kidney Disease - Nigra, A. E., Navas-Acien, A. J Am Soc Nephrol
• 19:51
  Toward Antiracist Reimbursement Policy in End-Stage Kidney Disease: From Equality to Equity - Taylor, K., Crews, D. C. J Am Soc Nephrol
• 19:51
  Associations of Community Water Lead Concentrations with Hemoglobin Concentrations and Erythropoietin-Stimulating Agent Use among Patients with Advanced CKD - Danziger, J., Mukamal, K. J., Weinhandl, E. J Am Soc Nephrol
  Background Although patients with kidney disease may be particularly susceptible to the adverse health effects associated with lead exposure, whether levels of lead found commonly in drinking water are associated with adverse outcomes in patients with ESKD is not known. Methods To investigate (...)
• 19:51
  Antibody Response to COVID-19 Vaccination in Patients Receiving Dialysis - Anand, S., Montez-Rath, M. E., Han, J., Garcia, P., Cadden, L., Hunsader, P., Kerschmann, R., Beyer, P., Dittrich, M., Block, G. A., Boyd, S. D., Parsonnet, J., Chertow, G. M. J Am Soc Nephrol
• 19:51
  Using both the Fraction and Quantity of Donor-Derived Cell-Free DNA to Detect Kidney Allograft Rejection - Bunnapradist, S., Homkrailas, P., Ahmed, E., Fehringer, G., Billings, P. R., Tabriziani, H. J Am Soc Nephrol
• 19:51
  Urine APOL1 Isoforms Reflect Plasma-Derived Liver-Synthesized Proteins - Althage, M., Heinrich, T. M., Miliotis, T., Bogstedt, A., Ma, L., Gautreaux, M. D., Hicks, P. J., Palmer, N. D., MacPhee, I., Hartleib-Geschwindner, J., Greasley, P. J., Freedman, B. I. J Am Soc Nephrol
• 19:51
  Renal Denervation Exacerbates LPS- and Antibody-induced Acute Kidney Injury, but Protects from Pyelonephritis in Mice - Bo?hner, A. M. C., Jacob, A. M., Heuser, C., Stumpf, N. E., Effland, A., Abdullah, Z., Meyer-Schwesiger, C., von Vietinghoff, S., Kurts, C. J Am Soc Nephrol
  Background Renal denervation (RDN) is an invasive intervention to treat drug-resistant arterial hypertension. Its therapeutic value is contentious. Here we examined the effects of RDN on inflammatory and infectious kidney disease models in mice. Methods Mice were unilaterally or bilaterally (...)
• 19:51
  O- and N-Glycosylation of Serum Immunoglobulin A is Associated with IgA Nephropathy and Glomerular Function - Dotz, V., Visconti, A., Lomax-Browne, H. J., Clerc, F., Hipgrave Ederveen, A. L., Medjeral-Thomas, N. R., Cook, H. T., Pickering, M. C., Wuhrer, M., Falchi, M. J Am Soc Nephrol
  Background IgA nephropathy (IgAN) is the most common primary glomerular disease worldwide and is a leading cause of renal failure. The disease mechanisms are not completely understood, but a higher abundance of galactose-deficient IgA is recognized to play a crucial role in IgAN pathogenesis. (...)
• 19:51
  Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform for RNAi to Treat AKI - Tang, T.-T., Wang, B., Li, Z.-L., Wen, Y., Feng, S.-T., Wu, M., Liu, D., Cao, J.-Y., Yin, Q., Yin, D., Fu, Y.-Q., Gao, Y.-M., Ding, Z.-Y., Qian, J.-Y., Wu, Q.-L., Lv, L.-L., Liu, B.-C. J Am Soc Nephrol
  Background AKI is a significant public health problem with high morbidity and mortality. Unfortunately, no definitive treatment is available for AKI. RNA interference (RNAi) provides a new and potent method for gene therapy to tackle this issue. Methods We engineered red blood cell–derived (...)
• 19:51
  Macula Densa NOS1beta Modulates Renal Hemodynamics and Blood Pressure during Pregnancy: Role in Gestational Hypertension - Wei, J., Zhang, J., Jiang, S., Xu, L., Qu, L., Pang, B., Jiang, K., Wang, L., Intapad, S., Buggs, J., Cheng, F., Mohapatra, S., Juncos, L. A., Osborn, J. L., Granger, J. P., Liu, R. J Am Soc Nephrol
  Background Regulation of renal hemodynamics and BP via tubuloglomerular feedback (TGF) may be an important adaptive mechanism during pregnancy. Because the β-splice variant of nitric oxide synthase 1 (NOS1β) in the macula densa is a primary modulator of TGF, we evaluated its role in (...)
• 19:51
  Single-Nucleus RNA Sequencing Identifies New Classes of Proximal Tubular Epithelial Cells in Kidney Fibrosis - Lu, Y.-A., Liao, C.-T., Raybould, R., Talabani, B., Grigorieva, I., Szomolay, B., Bowen, T., Andrews, R., Taylor, P. R., Fraser, D. J Am Soc Nephrol
  Background Proximal tubular cells (PTCs) are the most abundant cell type in the kidney. PTCs are central to normal kidney function and to regeneration versus organ fibrosis following injury. This study used single-nucleus RNA sequencing (snRNAseq) to describe the phenotype of PTCs in renal (...)
• 19:51
  High SARS-CoV-2 Viral Load in Urine Sediment Correlates with Acute Kidney Injury and Poor COVID-19 Outcome - Caceres, P. S., Savickas, G., Murray, S. L., Umanath, K., Uduman, J., Yee, J., Liao, T.-D., Bolin, S., Levin, A. M., Khan, M. N., Sarkar, S., Fitzgerald, J., Maskey, D., Ormsby, A. H., Sharma, Y., Ortiz, P. A. J Am Soc Nephrol
  Background AKI is a complication of coronavirus disease 2019 (COVID-19) that is associated with high mortality. Despite documented kidney tropism of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there are no consistent reports of viral detection in urine or correlation with (...)
• 19:51
  Integrative Cistromic and Transcriptomic Analyses Identify CREB Target Genes in Cystic Renal Epithelial Cells - Liu, Z., Liu, Y., Dang, L., Geng, M., Sun, Y., Lu, Y., Fang, Z., Xiong, H., Chen, Y. J Am Soc Nephrol
  Background Genome-wide mapping of transcription factor (TF) binding sites is essential to identify a TF’s direct target genes in kidney development and diseases. However, due to the cellular complexity of the kidney and limited numbers of a given cell type, it has been challenging to determine (...)
• 19:51
  Erythropoietin Reduces Auto- and Alloantibodies by Inhibiting T Follicular Helper Cell Differentiation - Guglielmo, C., Bin, S., Cantarelli, C., Hartzell, S., Angeletti, A., Donadei, C., Cumpelik, A., Anderson, L., Cody, E., Sage, P. T., La Manna, G., Fiaccadori, E., Heeger, P. S., Cravedi, P. J Am Soc Nephrol
  Background Although high-affinity IgG auto- and alloantibodies are important drivers of kidney inflammation that can result in ESKD, therapeutic approaches that effectively reduce such pathogenic antibodies remain elusive. Erythropoietin (EPO) has immunomodulatory functions, but its effects on (...)
• 19:51
  MicroRNA-23b-3p Deletion Induces an IgA Nephropathy-like Disease Associated with Dysregulated Mucosal IgA Synthesis - Li, H., Chen, Z., Chen, W., Li, J., Liu, Y., Ma, H., Shi, M., Sun, X., Yao, X., Li, Z., Pawluczyk, I. Z. A., Zhang, S., Barratt, J., Lv, J., Wang, K., Zhao, B. J Am Soc Nephrol
  Background IgA nephropathy (IgAN) is the most common primary GN worldwide. Circulating immune complexes form that are prone to deposition in the mesangium, where they trigger glomerular inflammation. A growing body of evidence suggests that dysregulated expression of microRNAs in IgAN may play (...)
• 19:51
  Cilastatin Ameliorates Rhabdomyolysis-induced AKI in Mice - Matsushita, K., Mori, K., Saritas, T., Eiwaz, M. B., Funahashi, Y., Nickerson, M. N., Hebert, J. F., Munhall, A. C., McCormick, J. A., Yanagita, M., Hutchens, M. P. J Am Soc Nephrol
  Background Rhabdomyolysis, the destruction of skeletal muscle, is a significant cause of AKI and death in the context of natural disaster and armed conflict. Rhabdomyolysis may also initiate CKD. Development of specific pharmacologic therapy is desirable because supportive care is nearly (...)
• 19:51
  The Prognostic Significance of Body Mass Index and Metabolic Parameter Variabilities in Predialysis CKD: A Nationwide Observational Cohort Study - Park, S., Cho, S., Lee, S., Kim, Y., Park, S., Kim, Y. C., Han, S. S., Lee, H., Lee, J. P., Joo, K. W., Lim, C. S., Kim, Y. S., Han, K., Kim, D. K. J Am Soc Nephrol
  Background The association between variabilities in body mass index (BMI) or metabolic parameters and prognosis of patients with CKD has rarely been studied. Methods In this retrospective observational study on the basis of South Korea’s national health screening database, we identified (...)
• 19:51
  Patient Health Outcomes following Dialysis Facility Closures in the United States - Niu, J., Saeed, M. K., Winkelmayer, W. C., Erickson, K. F. J Am Soc Nephrol
  Background Ongoing changes to reimbursement of United States dialysis care may increase the risk of dialysis facility closures. Closures may be particularly detrimental to the health of patients receiving dialysis, who are medically complex and clinically tenuous. Methods We used two separate (...)
• 19:51
  A Higher Foci Density of Interstitial Fibrosis and Tubular Atrophy Predicts Progressive CKD after a Radical Nephrectomy for Tumor - Ricaurte Archila, L., Denic, A., Mullan, A. F., Narasimhan, R., Bogojevic, M., Thompson, R. H., Leibovich, B. C., Sangaralingham, S. J., Smith, M. L., Alexander, M. P., Rule, A. D. J Am Soc Nephrol
  Background Chronic tubulointerstitial injury on kidney biopsy is usually quantified by the percentage of cortex with interstitial fibrosis/tubular atrophy (IF/TA). Whether other patterns of IF/TA or inflammation in the tubulointerstitium have prognostic importance beyond percentage IF/TA is (...)
• 19:51
  Association of Coding Variants in Hydroxysteroid 17-beta Dehydrogenase 14 (HSD17B14) with Reduced Progression to End Stage Kidney Disease in Type 1 Diabetes - Mychaleckyj, J. C., Valo, E., Ichimura, T., Ahluwalia, T. S., Dina, C., Miller, R. G., Shabalin, I. G., Gyorgy, B., Cao, J., Onengut-Gumuscu, S., Satake, E., Smiles, A. M., Haukka, J. K., Tregouet, D.-A., Costacou, T., ONeil, K., Paterson, A. D., Forsblom, C., Keenan, H. A., Pezzolesi, M. G., Pragnell, M., Galecki, A., Rich, S. S., Sandholm, N., Klein, R., Klein, B. E., Susztak, K., Orchard, T. J., Korstanje, R., King, G. L., Hadjadj, S., Rossing, P., Bonventre, J. V., Groop, P.-H., Warram, J. H., Krolewski, A. (...) J Am Soc Nephrol
  Background Rare variants in gene coding regions likely have a greater impact on disease-related phenotypes than common variants through disruption of their encoded protein. We searched for rare variants associated with onset of ESKD in individuals with type 1 diabetes at advanced kidney (...)
• 19:51
  Human or Chimeric Monoclonal Anti-CD20 Antibodies for Children with Nephrotic Syndrome: A Superiority Randomized Trial - Ravani, P., Colucci, M., Bruschi, M., Vivarelli, M., Cioni, M., DiDonato, A., Cravedi, P., Lugani, F., Antonini, F., Prunotto, M., Emma, F., Angeletti, A., Ghiggeri, G. M. J Am Soc Nephrol
  Background The chimeric anti-CD20 monoclonal antibody rituximab is effective in steroid-dependent and calcineurin inhibitor–dependent forms of nephrotic syndrome, but many patients relapse at 1 year. Because ofatumumab, a fully human anti-CD20 monoclonal antibody, has a more extended binding (...)
• 19:51
  Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in Children - Greenberg, J. H., Abraham, A. G., Xu, Y., Schelling, J. R., Feldman, H. I., Sabbisetti, V. S., Ix, J. H., Jogalekar, M. P., Coca, S., Waikar, S. S., Shlipak, M. G., Warady, B. A., Vasan, R. S., Kimmel, P. L., Bonventre, J. V., Denburg, M., Parikh, C. R., Furth, S., on behalf of the CKD Biomarkers Consortium, CKD Biomarker consortium, Ramachandran, Schelling, Denburg, Furth, Warady, Bonventre, Waikar, Sabbisetti, Coresh, Grams, Rebholz, Abraham, Parikh, Coca, Rhee, Kimmel, Kusek, Rovin, Shlipak, Sarnak, Gutierrez, Ix, Dubin, Hostetter, Deo, Feldman, Xie, Shou, Ballard, Whitehead, Collins, (...) J Am Soc Nephrol
  Background Novel urine biomarkers may improve identification of children at greater risk of rapid kidney function decline, and elucidate the pathophysiology of CKD progression. Methods We investigated the relationship between urine biomarkers of kidney tubular health (EGF and α-1 (...)
• 19:51
  Long-Term Outcomes of Children Undergoing Dialysis-treated AKI: Some Opinions and Prospects - Wei, S. J Am Soc Nephrol
• 19:51
  Pediatric Acute Kidney Injury Survivors Need Risk Stratification and Individualized Follow-Up - Zhao, Y., Pu, Y., Zhang, L., Fu, P. J Am Soc Nephrol
• 19:51
  Authors Reply - Robinson, C. H., Jeyakumar, N., Wald, R., Zappitelli, M., Chanchlani, R. J Am Soc Nephrol
• 19:51
  Correction: Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy J Am Soc Nephrol

31 August

J Am Soc Nephrol https://jasn.asnjournals.org/

• 20:00
  This Month's Highlights J Am Soc Nephrol
• 20:00
  Comparative Health Care Spending for Dialysis: An Example of Public Cost Containment? - Tummalapalli, S. L., Anderson, G. F. J Am Soc Nephrol
• 20:00
  The Bloody Mystery of Glomerular Tuft Development - Marciano, D. K. J Am Soc Nephrol
• 20:00
  Big Data and Glomerular Disease: Uncovering Common Outcomes of Rare Disease - Glenn, D. A., Hogan, S. L. J Am Soc Nephrol
• 20:00
  Predictors of Kidney Disease Progression in Diabetes and Precision Medicine: Something Old, Something New, and Something Borrowed - Vasquez-Rios, G., Coca, S. G. J Am Soc Nephrol
• 20:00
  Barriers to Reducing Hemodialysis Time and Frequency in Patients with Residual Kidney Function - Meyer, T. W., Blanco, I. J., Grimm, J. C., Leypoldt, J. K., Sirich, T. L. J Am Soc Nephrol
• 20:00
  Recent Approaches to Targeting Canonical NFkappaB Signaling in the Early Inflammatory Response to Renal IRI - Reid, S., Scholey, J. W. J Am Soc Nephrol
  Ischemia reperfusion injury (IRI) is the most common cause of in-hospital AKI and is associated with increased morbidity and mortality. IRI is associated with an early phase of inflammation primarily regulated by the canonical NFB signaling pathway. Despite recent advances in our understanding (...)
• 20:00
  Molecular Mechanisms of Renal Magnesium Reabsorption - Ellison, D. H., Maeoka, Y., McCormick, J. A. J Am Soc Nephrol
  Magnesium is an essential cofactor in many cellular processes, and aberrations in magnesium homeostasis can have life-threatening consequences. The kidney plays a central role in maintaining serum magnesium within a narrow range (0.70–1.10 mmol/L). Along the proximal tubule and thick ascending (...)
• 20:00
  Dialysis and Total Health Care Costs in the United States and Worldwide: The Financial Impact of a Single-Payer Dominant System in the US - Pockros, B. M., Finch, D. J., Weiner, D. E. J Am Soc Nephrol
• 20:00
  Hemodialysis Patients Make Long-Lived Antibodies against SARS-CoV-2 that May Be Associated with Reduced Reinfection - Banham, G. D., Godlee, A., Faustini, S. E., Cunningham, A. F., Richter, A., Harper, L., on behalf of the COVID-HD Birmingham Study Group J Am Soc Nephrol
• 20:00
  Racial Adjustment Adversely Affects Glomerular Filtration Estimates in Black Americans Living with HIV - Atta, M. G., Zook, K., Brown, T. T., Vaidya, D., Tao, X., Maier, P., Schwartz, G. J., Lucas, G. M. J Am Soc Nephrol
• 20:00
  Antibody and T Cell Response to SARS-CoV-2 Messenger RNA BNT162b2 Vaccine in Kidney Transplant Recipients and Hemodialysis Patients - Bertrand, D., Hamzaoui, M., Lemee, V., Lamulle, J., Hanoy, M., Laurent, C., Lebourg, L., Etienne, I., Lemoine, M., Le Roy, F., Nezam, D., Plantier, J.-C., Boyer, O., Guerrot, D., Candon, S. J Am Soc Nephrol
  Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with a high rate of mortality in patients with ESKD, and vaccination is hoped to prevent infection. Methods Between January 18 and February 24, 2021, 225 kidney transplant recipients (KTRs) and 45 patients (...)
• 20:00
  Humoral Response after SARS-CoV-2 mRNA Vaccination in a Cohort of Hemodialysis Patients and Kidney Transplant Recipients - Danthu, C., Hantz, S., Dahlem, A., Duval, M., Ba, B., Guibbert, M., El Ouafi, Z., Ponsard, S., Berrahal, I., Achard, J.-M., Bocquentin, F., Allot, V., Rerolle, J.-P., Alain, S., Toure, F. J Am Soc Nephrol
  Background Kidney transplant recipients and patients receiving hemodialysis are immunocompromised populations that are prioritized for COVID-19 vaccination but were excluded from clinical trials of SARS-CoV-2 mRNA vaccines. Antibody titers and rates of seroconversion after vaccination are (...)
• 20:00
  Inhibiting Focal Adhesion Kinase Ameliorates Cyst Development in Polycystin-1-Deficient Polycystic Kidney Disease in Animal Model - He, J., Zhang, S., Qiu, Z., Li, X., Huang, H., Jin, W., Xu, Y., Shao, G., Wang, L., Meng, J., Wang, S., Geng, X., Jia, Y., Li, M., Yang, B., Jenny Lu, H. A., Zhou, H. J Am Soc Nephrol
  Background Autosomal dominant polycystic kidney disease (ADPKD) is characterized by numerous cysts originating from renal tubules and is associated with significant tubular epithelial cell proliferation. Focal adhesion kinase (FAK) promotes tumor growth by regulating multiple proliferative (...)
• 20:00
  Tripartite Separation of Glomerular Cell Types and Proteomes from Reporter-Free Mice - Hatje, F. A., Wedekind, U., Sachs, W., Loreth, D., Reichelt, J., Demir, F., Kosub, C., Heintz, L., Tomas, N. M., Huber, T. B., Skuza, S., Sachs, M., Zielinski, S., Rinschen, M. M., Meyer-Schwesinger, C. J Am Soc Nephrol
  Background The glomerulus comprises podocytes, mesangial cells, and endothelial cells, which jointly determine glomerular filtration. Understanding this intricate functional unit beyond the transcriptome requires bulk isolation of these cell types for biochemical investigations. We developed a (...)
• 20:00
  Large-Scale Proteomic Assessment of Urinary Extracellular Vesicles Highlights Their Reliability in Reflecting Protein Changes in the Kidney - Wu, Q., Poulsen, S. B., Murali, S. K., Grimm, P. R., Su, X.-T., Delpire, E., Welling, P. A., Ellison, D. H., Fenton, R. A. J Am Soc Nephrol
  Background Urinary extracellular vesicles (uEVs) are secreted into urine by cells from the kidneys and urinary tract. Although changes in uEV proteins are used for quantitative assessment of protein levels in the kidney or biomarker discovery, whether they faithfully reflect (patho)physiologic (...)
• 20:00
  Sex-Dependent Effects of Nephron Ift88 Disruption on BP, Renal Function, and Cystogenesis - Hu, C., Lakshmipathi, J., Binning, E., Hyndman, K. A., Stuart, D., Kohan, D. E. J Am Soc Nephrol
  Background Primary cilia regulation of renal function and BP in health and disease is incompletely understood. This study investigated the effect of nephron ciliary loss on renal physiology, BP, and ensuing cystogenesis. Methods Mice underwent doxycycline (DOX)-inducible nephron-specific (...)
• 20:00
  Signatures and Specificity of Tissue-Resident Lymphocytes Identified in Human Renal Peritumor and Tumor Tissue - Dornieden, T., Sattler, A., Pascual-Reguant, A., Ruhm, A. H., Thiel, L. G., Bergmann, Y. S., Thole, L. M. L., Ko?hler, R., Ku?hl, A. A., Hauser, A. E., Boral, S., Friedersdorff, F., Kotsch, K. J Am Soc Nephrol
  Background Tissue-resident memory T (TRM) cells are known to be important for the first line of defense in mucosa-associated tissues. However, the composition, localization, effector function, and specificity of TRM cells in the human kidney and their relevance for renal pathology have not (...)
• 20:00
  Human Kidney Spheroids and Monolayers Provide Insights into SARS-CoV-2 Renal Interactions - Omer, D., Pleniceanu, O., Gnatek, Y., Namestnikov, M., Cohen-Zontag, O., Goldberg, S., Friedman, Y. E., Friedman, N., Mandelboim, M., Vitner, E. B., Achdout, H., Avraham, R., Zahavy, E., Israely, T., Mayan, H., Dekel, B. J Am Soc Nephrol
  Background Although coronavirus disease 2019 (COVID-19) causes significan t morbidity, mainly from pulmonary involvement, extrapulmonary symptoms are also major componen ts of the disease. Kidney disease, usually presenting as AKI, is particularly severe among patients with COVID-19. It is (...)
• 20:00
  Slit2-Robo Signaling Promotes Glomerular Vascularization and Nephron Development - Li, J., Geraldo, L. H., Dubrac, A., Zarkada, G., Eichmann, A. J Am Soc Nephrol
  Background Kidney function requires continuous blood filtration by glomerular capillaries. Disruption of glomerular vascular development or maintenance contributes to the pathogenesis of kidney diseases, but the signaling events regulating renal endothelium development remain incompletely (...)
• 20:00
  Prevalence Estimates of Predicted Pathogenic COL4A3-COL4A5 Variants in a Population Sequencing Database and Their Implications for Alport Syndrome - Gibson, J., Fieldhouse, R., Chan, M. M. Y., Sadeghi-Alavijeh, O., Burnett, L., Izzi, V., Persikov, A. V., Gale, D. P., Storey, H., Savige, J., on behalf of the Genomics England Research Consortium J Am Soc Nephrol
  Background The reported prevalence of Alport syndrome varies from one in 5000 to one in 53,000 individuals. This study estimated the frequencies of predicted pathogenic COL4A3–COL4A5 variants in sequencing databases of populations without known kidney disease. Methods Predicted pathogenic (...)
• 20:00
  Proteins Associated with Risk of Kidney Function Decline in the General Population - Grams, M. E., Surapaneni, A., Chen, J., Zhou, L., Yu, Z., Dutta, D., Welling, P. A., Chatterjee, N., Zhang, J., Arking, D. E., Chen, T. K., Rebholz, C. M., Yu, B., Schlosser, P., Rhee, E. P., Ballantyne, C. M., Boerwinkle, E., Lutsey, P. L., Mosley, T., Feldman, H. I., Dubin, R. F., Ganz, P., Lee, H., Zheng, Z., Coresh, J. J Am Soc Nephrol
  Background Proteomic profiling may allow identification of plasma proteins that associate with subsequent changesin kidney function, elucidating biologic processes underlying the development and progression of CKD. Methods We quantified the association between 4877 plasma proteins and a (...)
• 20:00
  Primary Nephrotic Syndrome and Risks of ESKD, Cardiovascular Events, and Death: The Kaiser Permanente Nephrotic Syndrome Study - Go, A. S., Tan, T. C., Chertow, G. M., Ordonez, J. D., Fan, D., Law, D., Yankulin, L., Wojcicki, J. M., Zheng, S., Chen, K. K., Khoshniat-Rad, F., Yang, J., Parikh, R. V. J Am Soc Nephrol
  Background Little population-based data exist about adults with primary nephrotic syndrome. Methods To evaluate kidney, cardiovascular, and mortality outcomes in adults with primary nephrotic syndrome, we identified adults within an integrated health care delivery system (Kaiser Permanente (...)
• 20:00
  Self-Reported Medication Use and Urinary Drug Metabolites in the German Chronic Kidney Disease (GCKD) Study - Kotsis, F., Schultheiss, U. T., Wuttke, M., Schlosser, P., Mielke, J., Becker, M. S., Oefner, P. J., Karoly, E. D., Mohney, R. P., Eckardt, K.-U., Sekula, P., Ko?ttgen, A., on behalf of the GCKD Investigators, GCKD Investigators, Eckardt, Meiselbach, Schneider, Schiffer, Prokosch, Ba?rthlein, Beck, Reis, Ekici, Becker, Becker-Grosspitsch, Alberth-Schmidt, Hausknecht, Weigel, Walz, Ko?ttgen, Schultheiss, Kotsis, Meder, Mitsch, Reinhard, Floege, Saritas, Schaeffner, Baid-Agrawal, Theisen, Haller, Menne, Zeier, Sommerer, Theilinger, Wolf, Busch, Paul, Sitter, Wanner, Krane, Bo?rner-Klein, (...) J Am Soc Nephrol
  Background Polypharmacy is common among patients with CKD, but little is known about the urinary excretion of many drugs and their metabolites among patients with CKD. Methods To evaluate self-reported medication use in relation to urine drug metabolite levels in a large cohort of patients (...)
• 20:00
  Comprehensive Search for Novel Circulating miRNAs and Axon Guidance Pathway Proteins Associated with Risk of ESKD in Diabetes - Satake, E., Saulnier, P.-J., Kobayashi, H., Gupta, M. K., Looker, H. C., Wilson, J. M., Md Dom, Z. I., Ihara, K., ONeil, K., Krolewski, B., Pipino, C., Pavkov, M. E., Nair, V., Bitzer, M., Niewczas, M. A., Kretzler, M., Mauer, M., Doria, A., Najafian, B., Kulkarni, R. N., Duffin, K. L., Pezzolesi, M. G., Kahn, C. R., Nelson, R. G., Krolewski, A. S. J Am Soc Nephrol
  Background Mechanisms underlying the pro gression of diabetic kidney disease to ESKD are not fully understood. Methods We performed global microRNA (miRNA) analysis on plasma from two cohorts consisting of 375 individuals with type 1 and type 2 diabetes with late diabetic kidney disease, and (...)
• 20:00
  Effects of Dapagliflozin in Stage 4 Chronic Kidney Disease - Chertow, G. M., Vart, P., Jongs, N., Toto, R. D., Gorriz, J. L., Hou, F. F., McMurray, J. J. V., Correa-Rotter, R., Rossing, P., Sjo?stro?m, C. D., Stefansson, B. V., Langkilde, A. M., Wheeler, D. C., Heerspink, H. J. L., DAPA-CKD Trial Committees and Investigators J Am Soc Nephrol
  Background In the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized, placebo-controlled trial, the sodium-glucose cotransporter 2 inhibitor dapagliflozin significantly reduced risk of kidney failure and prolonged survival in patients with CKD with (...)
• 20:00
  Reappraisal of Renal Arteritis in ANCA-associated Vasculitis: Clinical Characteristics, Pathology, and Outcome - Boudhabhay, I., Delestre, F., Coutance, G., Gnemmi, V., Quemeneur, T., Vandenbussche, C., Lazareth, H., Canaud, G., Tricot, L., Gosset, C., Hummel, A., Terrier, B., Rabant, M., van Daalen, E. E., Wester Trejo, M. A. C., Bajema, I. M., Karras, A., Duong Van Huyen, J.-P. J Am Soc Nephrol
  Background Renal involvement in ANCA–associated vasculitis (AAV) is associated with poor outcomes. The clinical significance of arteritis of the small kidney arteries has not been evaluated in detail. Methods In a multicenter cohort of patients with AAV and renal involvement, we sought to (...)
• 20:00
  High Oxalate Concentrations Correlate with Increased Risk for Sudden Cardiac Death in Dialysis Patients - Pfau, A., Ermer, T., Coca, S. G., Tio, M. C., Genser, B., Reichel, M., Finkelstein, F. O., Ma?rz, W., Wanner, C., Waikar, S. S., Eckardt, K.-U., Aronson, P. S., Drechsler, C., Knauf, F. J Am Soc Nephrol
  Background The clinical significance of accumulating toxic terminal metabolites such as oxalate in patients with kidney failure is not well understood. Methods To evaluate serum oxalate concentrations and risk of all-cause mortality and cardiovascular events in a cohort of patients with (...)
• 20:00
  Novel Phenotypes for Acute Kidney Transplant Rejection Using Semi-Supervised Clustering - Matas, A. J., Mannon, R. B., Rush, D., Helgeson, E. J Am Soc Nephrol
• 20:00
  Authors Reply - Vaulet, T., Thaunat, O., Naesens, M. J Am Soc Nephrol
• 20:00
  Addressing Transplant Candidacy When Evaluating Safety of Direct Oral Anticoagulant Agents in Patients on Hemodialysis - Heher, E., Elias, N. J Am Soc Nephrol
• 20:00
  Authors Reply - De Vriese, A. S. J Am Soc Nephrol

30 July

J Am Soc Nephrol https://jasn.asnjournals.org/

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  This Month's Highlights J Am Soc Nephrol
• 20:00
  Transplant Biopsy Assessment in 21st Century - Malone, A. F. J Am Soc Nephrol
• 20:00
  Biobanks Linked to Electronic Health Records Accelerate Genomic Discovery - Crawford, D. C., Sedor, J. R. J Am Soc Nephrol
• 20:00
  Novel Insights into Mechanisms of Intestinal Phosphate Absorption in Patients with Chronic Kidney Disease - Kritmetapak, K., Kumar, R. J Am Soc Nephrol
• 20:00
  Prevention of Post-Transplantation Diabetes: Small Steps, Big Opportunities - Sharif, A. J Am Soc Nephrol
• 20:00
  Procurement Biopsies in Kidney Transplantation: More Information May Not Lead to Better Decisions - Lentine, K. L., Kasiske, B., Axelrod, D. A. J Am Soc Nephrol
• 20:00
  Current Methodological Challenges of Single-Cell and Single-Nucleus RNA-Sequencing in Glomerular Diseases - Deleersnijder, D., Callemeyn, J., Arijs, I., Naesens, M., Van Craenenbroeck, A. H., Lambrechts, D., Sprangers, B. J Am Soc Nephrol
  Single-cell RNA sequencing (scRNA-seq) and single-nucleus RNA-seq (snRNA-seq) allow transcriptomic profiling of thousands of cells from a renal biopsy specimen at a single-cell resolution. Both methods are promising tools to unravel the underlying pathophysiology of glomerular diseases. This (...)
• 20:00
  Circulating Soluble Fms-like Tyrosine Kinase in Renal Diseases Other than Preeclampsia - Wewers, T. M., Schulz, A., Nolte, I., Pavensta?dt, H., Brand, M., Di Marco, G. S. J Am Soc Nephrol
  Soluble Fms-like tyrosine kinase (sFlt-1/sVEGFR1) is a naturally occurring antagonist of vascular endothelial growth factor (VEGF). Despite being a secreted, soluble protein lacking cytoplasmic and transmembrane domains, sFlt-1 can act locally and be protective against excessive (...)
• 20:00
  Presence of SARS-CoV-2 Antibodies in Spent Peritoneal Dialysate - Wang, X., Grobe, N., Patel, A., Sharma, S., Uribarri, J., Kotanko, P. J Am Soc Nephrol
• 20:00
  Race-Free Equations for eGFR: Comparing Effects on CKD Classification - Diao, J. A., Powe, N. R., Manrai, A. K. J Am Soc Nephrol
• 20:00
  A Biallelic Frameshift Mutation in Nephronectin Causes Bilateral Renal Agenesis in Humans - Dai, L., Li, J., Xie, L., Wang, W., Lu, Y., Xie, M., Huang, J., Shen, K., Yang, H., Pei, C., Zhao, Y., Zhang, W. J Am Soc Nephrol
  Background Bilateral renal agenesis (BRA) is a lethal con genital anomaly caused by the failure of normal development of both kidneys early in embryonic development. Oligohydramnios on fetal ultrasonography reveals BRA. Although the exact causes are not clear, BRA is associated with mutations (...)
• 20:00
  Antibody Status, Disease History, and Incidence of SARS-CoV-2 Infection Among Patients on Chronic Dialysis - Cohen, D. E., Sibbel, S., Marlowe, G., Bludorn, K., Miller, D., Kelley, T., Connaire, J., Young, A., Tentori, F., Brunelli, S. M. J Am Soc Nephrol
  Background Although reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rare among individuals with few coronavirus disease 2019 (COVID-19) risk factors, the ability of naturally acquired immunity to prevent reinfection among patients with ESKD is not known. (...)
• 20:00
  Laminin-521 is a Novel Target of Autoantibodies Associated with Lung Hemorrhage in Anti-GBM Disease - Shen, C.-r., Jia, X.-y., Luo, W., Olaru, F., Cui, Z., Zhao, M.-h., Borza, D.-B. J Am Soc Nephrol
  Background Antiglomerular basement membrane (anti-GBM) disease is characterized by GN and often pulmonary hemorrhage, mediated by autoantibodies that typically recognize cryptic epitopes within α345(IV) collagen—a major component of the glomerular and alveolar basement membranes. (...)
• 20:00
  Increasing mTORC1 Pathway Activity or Methionine Supplementation during Pregnancy Reverses the Negative Effect of Maternal Malnutrition on the Developing Kidney - Makayes, Y., Resnick, E., Hinden, L., Aizenshtein, E., Shlomi, T., Kopan, R., Nechama, M., Volovelsky, O. J Am Soc Nephrol
  Background Low nephron number at birth is associated with a high risk of CKD in adulthood because nephrogenesis is completed in utero. Poor intrauterine environment impairs nephron endowment via an undefined molecular mechanism. A calorie-restricted diet (CRD) mouse model examined the effect (...)
• 20:00
  TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease - Cordido, A., Nunez-Gonzalez, L., Martinez-Moreno, J. M., Lamas-Gonzalez, O., Rodriguez-Osorio, L., Perez-Gomez, M. V., Martin-Sanchez, D., Outeda, P., Chiaravalli, M., Watnick, T., Boletta, A., Diaz, C., Carracedo, A., Sanz, A. B., Ortiz, A., Garcia-Gonzalez, M. A. J Am Soc Nephrol
  Background In autosomal dominant polycystic kidney disease (ADPKD), cyst development and enlargement lead to ESKD. Macrophage recruitment and interstitial inflammation promote cyst growth. TWEAK is a TNF superfamily (TNFSF) cytokine that regulates inflammatory responses, cell proliferation, (...)
• 20:00
  Data-Driven Kidney Transplant Phenotyping as a Histology-Independent Framework for Biomarker Discovery - Buscher, K., Heitplatz, B., van Marck, V., Song, J., Loismann, S., Rixen, R., Hu?chtmann, B., Kurian, S., Ehinger, E., Wolf, D., Ley, K., Pavensta?dt, H., Reuter, S. J Am Soc Nephrol
  Background In transplant medicine, clinical decision making largely relies on histology of biopsy specimens. However, histology suffers from low specificity, sensitivity, and reproducibility, leading to suboptimal stratification of patients. We developed a histology-independent immune (...)
• 20:00
  Phase Separation of MAGI2-Mediated Complex Underlies Formation of Slit Diaphragm Complex in Glomerular Filtration Barrier - Zhang, H., Lin, L., Liu, J., Pan, L., Lin, Z., Zhang, M., Zhang, J., Cao, Y., Zhu, J., Zhang, R. J Am Soc Nephrol
  Background Slit diaphragm is a specialized adhesion junction between the opposing podocytes, establishing the final filtration barrier to urinary protein loss. At the cytoplasmic insertion site of each slit diaphragm there is an electron-dense and protein-rich cellular compartment that is (...)
• 20:00
  Uncovering Modifier Genes of X-Linked Alport Syndrome Using a Novel Multiparent Mouse Model - Takemon, Y., Wright, V., Davenport, B., Gatti, D. M., Sheehan, S. M., Letson, K., Savage, H. S., Lennon, R., Korstanje, R. J Am Soc Nephrol
  Background Mutations in COL4A5 are responsible for 80% of cases of X-linked Alport Syndrome (XLAS). Although genes that cause AS are well characterized, people with AS who have similar genetic mutations present with a wide variation in the extent of kidney impairment and age of onset, (...)
• 20:00
  REST and Stress Resistance in the Aging Kidney - Magassa, S., Aron, L., Hoguin, C., Isnard, P., Terzi, F., Legendre, C., Yankner, B. A., Canaud, G. J Am Soc Nephrol
  Background CKD is associated with the loss of functional nephr ons, leading to increased mechanical and metabolic stress in the remaining cells, particularly for cells constituting the filtration barrier, such as podocytes. The failure of podocytes to mount an adequate stress response can lead (...)
• 20:00
  Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy - Kim, S. R., Puranik, A. S., Jiang, K., Chen, X., Zhu, X.-Y., Taylor, I., Khodadadi-Jamayran, A., Lerman, A., Hickson, L. J., Childs, B. G., Textor, S. C., Tchkonia, T., Niewold, T. B., Kirkland, J. L., Lerman, L. O. J Am Soc Nephrol
  Background Peripheral vascular diseases may induce chronic ischemia and cellular injury distal to the arterial obstruction. Cellular senescence involves proliferation arrest in response to stress, which can damage neighboring cells. Renal artery stenosis (RAS) induces stenotic-kidney (...)
• 20:00
  Long-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort Study - Robinson, C. H., Jeyakumar, N., Luo, B., Wald, R., Garg, A. X., Nash, D. M., McArthur, E., Greenberg, J. H., Askenazi, D., Mammen, C., Thabane, L., Goldstein, S., Parekh, R. S., Zappitelli, M., Chanchlani, R. J Am Soc Nephrol
  Background AKI is common during pediatric hospitalizations and associated with adverse short-term outcomes. However, long-term outcomes among survivors of pediatric AKI who received dialysis remain uncertain. Methods To determine the long-term risk of kidney failure (defined as receipt of (...)
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  Serum Biomarkers of Iron Stores Are Associated with Increased Risk of All-Cause Mortality and Cardiovascular Events in Nondialysis CKD Patients, with or without Anemia - Guedes, M., Muenz, D. G., Zee, J., Bieber, B., Stengel, B., Massy, Z. A., Mansencal, N., Wong, M. M. Y., Charytan, D. M., Reichel, H., Waechter, S., Pisoni, R. L., Robinson, B. M., Pecoits-Filho, R., CKDopps Investigators J Am Soc Nephrol
  Background Approximately 30%–45% of patients with nondialysis CKD have iron deficiency. Iron therapy in CKD has focused primarily on supporting erythropoiesis. In patients with or without anemia, there has not been a comprehensive approach to estimating the association between serum biomarkers (...)
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  Medical Records-Based Genetic Studies of the Complement System - Khan, A., Shang, N., Petukhova, L., Zhang, J., Shen, Y., Hebbring, S. J., Moncrieffe, H., Kottyan, L. C., Namjou-Khales, B., Knevel, R., Raychaudhuri, S., Karlson, E. W., Harley, J. B., Stanaway, I. B., Crosslin, D., Denny, J. C., Elkind, M. S. V., Gharavi, A. G., Hripcsak, G., Weng, C., Kiryluk, K. J Am Soc Nephrol
  Background Genetic variants in complement genes have been associated with a wide range of human disease states, but well-powered genetic association studies of complement activation have not been performed in large multiethnic cohorts. Methods We performed medical records–based genome-wide and (...)
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  Racial and Neighborhood-Level Disparities in COVID-19 Incidence among Patients on Hemodialysis in New York City - Tummalapalli, S. L., Silberzweig, J., Cukor, D., Lin, J. T., Barbar, T., Liu, Y., Kim, K., Parker, T. S., Levine, D. M., Ibrahim, S. A. J Am Soc Nephrol
  Background The coronavirus disease 2019 (COVID-19) pandemic has disproportionately affected socially disadvantaged populations. Whether disparities in COVID-19 incidence related to race/ethnicity and socioeconomic factors exist in the hemodialysis population is unknown. Methods Our study (...)
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  Intestinal Phosphorus Absorption in Moderate CKD and Healthy Adults Determined Using a Radioisotopic Tracer - Stremke, E. R., Wiese, G. N., Moe, S. M., Wastney, M. E., Moorthi, R. N., Hill Gallant, K. M. J Am Soc Nephrol
  Background Reducing intestinal phosphorus absorption is a cornerstone in CKD-MBD management. Yet, knowledge gaps include how CKD pathophysiology affects intestinal phosphorus absorption. In vivo rodent studies suggest that intestinal phosphorus absorption remains inappropriately normal in (...)
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  Missing Self-Induced Microvascular Rejection of Kidney Allografts: A Population-Based Study - Callemeyn, J., Senev, A., Coemans, M., Lerut, E., Sprangers, B., Kuypers, D., Koenig, A., Thaunat, O., Emonds, M.-P., Naesens, M. J Am Soc Nephrol
  Background Circulating anti-HLA donor-specific antibodies (HLA-DSA) are often absent in kidney transplant recipients with microvascular inflammation (MVI). Missing self, the inability of donor endothelial cells to provide HLA I–mediated signals to inhibitory killer cell Ig-like receptors (KIRs) (...)
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  Early Postoperative Basal Insulin Therapy versus Standard of Care for the Prevention of Diabetes Mellitus after Kidney Transplantation: A Multicenter Randomized Trial - Schwaiger, E., Krenn, S., Kurnikowski, A., Bergfeld, L., Perez-Saez, M. J., Frey, A., Topitz, D., Bergmann, M., Ho?dlmoser, S., Bachmann, F., Halleck, F., Kron, S., Hafner-Giessauf, H., Eller, K., Rosenkranz, A. R., Crespo, M., Faura, A., Tura, A., Song, P. X. K., Port, F. K., Pascual, J., Budde, K., Ristl, R., Werzowa, J., Hecking, M. J Am Soc Nephrol
  Background Post-transplantation diabetes mellitus (PTDM) might be preventable. Methods This open-label, multicenter randomized trial compared 133 kidney transplant recipients given intermediate-acting insulin isophane for postoperative afternoon glucose ≥140 mg/dl with 130 patients given (...)
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  Considerations in Comparing Proximal Tubule Cell Culture Models - Weisz, O. A. J Am Soc Nephrol
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  Correction: Long-Term Exposure to Ambient PM2.5 and Increased Risk of Chronic Kidney Disease Prevalence in China J Am Soc Nephrol