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272 posts
21 January
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Gut Dysbiosis in Experimental Kidney Disease: A Meta-Analysis of Rodent Repository Data - J Am Soc NephrolBackground Rodent studies have popularized the notion that uremia may induce pathologic changes in the gut microbiota that contribute to kidney disease progression. Although single-cohort rodent studies have yielded insights into host-microbiota relationships in various disease processes, their (...) -- Meta-analysis - Chronic Kidney Disease
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07:00Prevalence of Self-reported Kidney Disease in Older Adults by Sexual Orientation: Behavioral Risk Factor Surveillance System Analysis (2014-2019) - J Am Soc NephrolBackground: Existing research documents disparities in chronic kidney disease (CKD) by age, race/ethnicity, and access to health care. However, research on CKD in LGBT+ older adults, despite their higher rates of diabetes, heart disease, smoking, and alcohol use, is limited Methods: Pooled data (...) -- Clinical Research - Chronic Kidney Disease
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07:00Protein Carbamylation and the Risk of End-Stage Kidney Disease in Patients with Chronic Kidney Disease - J Am Soc NephrolBackground Protein carbamylation, a posttranslational protein modification partially driven by elevated blood urea levels, associates with adverse outcomes in end-stage kidney disease (ESKD). However, little is known about protein carbamylation’s relationship to clinical outcomes in the much (...) -- Clinical Research - Chronic Kidney Disease
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07:00Hyperactivation of YAP/TAZ Drives Alterations in Mesangial Cells through Stabilization of N-Myc in Diabetic Nephropathy - J Am Soc NephrolBackground: Mesangial cells (MCs) in the kidney are central to maintaining glomerular integrity, and their impairment leads to major glomerular diseases including diabetic nephropathy (DN). Although high blood glucose elicits abnormal alterations in MCs, the underlying molecular mechanism is (...) -- Basic Research - Chronic Kidney Disease
20 January
J Am Soc Nephrol https://jasn.asnjournals.org/
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No abstract available -- Perspective
17 January
J Am Soc Nephrol https://jasn.asnjournals.org/
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Background The effect of intensive BP lowering (to systolic BP of -- Original Article - Meta-analysis
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No abstract available -- Editorial
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07:00Navigating the Dobbs Versus Jackson America for Patients with CKD and Kidney Transplants - J Am Soc NephrolNo abstract available -- Perspective
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No abstract available -- Editorial
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07:00The Importance of Maintaining Reproductive Choices for Kidney Transplant Recipients - J Am Soc NephrolNo abstract available -- Perspective
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07:00ADAMTS7-Mediated Complement Factor H Degradation Potentiates Complement Activation to Contributing to Renal Injuries - J Am Soc NephrolBackground The dysfunction of complement factor H (CFH), the main soluble complement negative regulator, potentiates various complement-induced renal injuries. However, insights into the underlying mechanism of CFH dysfunction remain limited. In this study, we investigated whether extracellular (...) -- Basic Research
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07:00Tubular Epithelial Cell HMGB1 Promotes AKI-CKD Transition by Sensitizing Cycling Tubular Cells to Oxidative Stress: A Rationale for Targeting HMGB1 during AKI Recovery - J Am Soc NephrolBackground Late diagnosis is a hurdle for treatment of acute kidney injury (AKI), but targeting AKI-CKD transition may improve outcomes. High mobility group box-1 (HMGB1) is a nuclear regulator of transcription and a driver of necroinflammation in AKI. We hypothesized that HMGB1 would also (...) -- Basic Research: Original Article
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07:00The nephrologist’s role in supporting people with chronic kidney disease and unplanned pregnancy post-Dobbs - J Am Soc NephrolNo abstract available -- Perspective
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07:00A Clinical Workflow for Cost-saving High-rate Diagnosis of Genetic Kidney Diseases - J Am Soc NephrolBackground: Whole-exome sequencing increases the diagnostic rate of genetic kidney disorders but accessibility, interpretation of results, and costs limit use in daily practice. Methods: Univariable analysis of a historical cohort of 392 patients who underwent whole-exome sequencing for kidney (...) -- Original Article - Clinical Research
13 January
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Immune Checkpoint Molecule TIGIT Regulates Kidney T Cell Functions and Contributes to Acute Kidney Injury - J Am Soc NephrolBackground: T cells play pathogenic and reparative roles during acute kidney injury (AKI). However, mechanisms regulating T cell responses are relatively unknown. We investigated the roles of the novel immune checkpoint molecule T cell immunoreceptor with Ig and ITIM domains (TIGIT) in kidney T (...) -- Original Article - Basic Research
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07:00Podocyte Geranylgeranyl Transferase Type-I Is Essential for Maintenance of the Glomerular Filtration Barrier - J Am Soc NephrolBackground Impairment of the glomerular filtration barrier is in part attributed to podocyte foot process effacement, entailing disruption of the actin cytoskeleton and the slit diaphragm. Maintenance of the actin cytoskeleton, which contains a complex signaling network through its connections (...) -- Original Article - Basic Research
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07:00Lineage Tracing and Single-Nucleus Multiomics Reveal Novel Features of Adaptive and Maladaptive Repair after Acute Kidney Injury Single-Cell Multiomics of AKI Responses - J Am Soc NephrolBackground Acute kidney injury (AKI) triggers a proliferative response as part of an intrinsic cellular repair program, which can lead to adaptive renal repair, restoring kidney structure and function, or maladaptive repair with persistence of injured proximal tubule cells (PTCs) and an altered (...) -- Original Article - Basic Research
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No abstract available -- Perspective: Chronic Kidney Disease
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07:00Membranous Nephropathy in Syphilis is Associated with Neuron-Derived Neurotrophic Factor - J Am Soc NephrolBackground: Syphilis is a common sexually transmitted infection. Membranous nephropathy (MN) is a common cause of proteinuria in syphilis. The target antigen is not known in most cases of syphilis-associated MN. Methods: We performed laser microdissection of glomeruli and mass spectrometry (...) -- Original Article - Rapid Communications
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07:00Genetic and Physiological Effects of Insulin-like Growth factor-1 (IGF-1) on Human Urate Homeostasis - J Am Soc NephrolBackground: Metabolic syndrome and hyperinsulinemia are associated with hyperuricemia. Insulin infusion in healthy volunteers elevates serum urate (SU) by activating net urate reabsorption in the renal proximal tubule, whereas IGF-1 infusion reduces SU by mechanisms unknown. Variation within (...) -- Original Article - Basic Research
5 January
J Am Soc Nephrol https://jasn.asnjournals.org/
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No abstract available -- Invited Perspective
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Background: Primary membranous nephropathy (MN) is an autoimmune kidney disease in which immune complexes are deposited beneath the epithelium in the glomeruli. The condition introduces a high risk for end-stage kidney disease. Seventy to 80 percent of MN patients have circulating antibodies (...) -- Research Letters
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Background: The incidence of chronic kidney disease (CKD) is associated with genetic factors. However, genetic markers associated with the progression of CKD have not been fully elucidated. Methods: We conducted a genome-wide association study among 1,738 CKD patients, mainly from the KoreaN (...) -- Original Article - Clinical Research
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07:00Utilization and Outcomes of Clinically Indicated Invasive Cardiac Care in Veterans with Acute Coronary Syndrome and Chronic Kidney Disease - J Am Soc NephrolBackground Previous studies have shown that patients with chronic kidney disease (CKD) are less likely than those without CKD to receive invasive care to treat acute coronary syndrome. However, few studies have accounted for whether such care was clinically indicated or assessed whether nonuse (...) -- Original Article - Clinical Research
15 December
J Am Soc Nephrol https://jasn.asnjournals.org/
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Background: Hepatocyte nuclear factor 1-beta (HNF1B) is an essential transcription factor during embryogenesis. Mutations in HNF1B are the most common monogenic causes of congenital cystic dysplastic renal malformations. The direct functional consequences of mutations in HNF1B on its (...) -- Original Article - Basic Research
30 November
J Am Soc Nephrol https://jasn.asnjournals.org/
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19:00Artificial Intelligence You Can Trust: What Matters Beyond Performance When Applying Artificial Intelligence to Renal Histopathology? - J Am Soc NephrolAlthough still in its infancy, artificial intelligence (AI) analysis of kidney biopsy images is anticipated to become an integral aspect of renal histopathology. As these systems are developed, the focus will understandably be on developing ever more accurate models, but successful translation (...)
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19:00Designing Interventions Addressing Structural Racism to Reduce Kidney Health Disparities: A Report from a National Institute of Diabetes and Digestive and Kidney Diseases Workshop - J Am Soc NephrolStructural racism embodies the many ways in which society fosters racial discrimination through "mutually reinforcing inequitable systems" that limit access to resources and opportunities that can promote health and well being among marginalized communities. To achieve health equity, and kidney (...)
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19:00Activation of Stimulator of IFN Genes (STING) Causes Proteinuria and Contributes to Glomerular Diseases - J Am Soc NephrolBackground The signaling molecule stimulator of IFN genes (STING) was identified as a crucial regulator of the DNA-sensing cyclic GMP-AMP synthase (cGAS)-STING pathway, and this signaling pathway regulates inflammation and energy homeostasis under conditions of obesity, kidney fibrosis, and (...)
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19:00Nephrotic Syndrome Gene TBC1D8B Is Required for Endosomal Maturation and Nephrin Endocytosis in Drosophila - J Am Soc NephrolBackground Variants in TBC1D8B cause nephrotic syndrome. TBC1D8B is a GTPase-activating protein for Rab11 (RAB11-GAP) that interacts with nephrin, but how it controls nephrin trafficking or other podocyte functions remains unclear. Methods We generated a stable deletion in Tbc1d8b and used (...)
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19:00Anatomical Evidence for Parasympathetic Innervation of the Renal Vasculature and Pelvis - J Am Soc NephrolBackground The kidneys critically contribute to body homeostasis under the control of the autonomic nerves, which enter the kidney along the renal vasculature. Although the renal sympathetic and sensory nerves have long been confirmed, no significant anatomic evidence exists for renal (...)
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19:00Effector Memory-Expressing CD45RA (TEMRA) CD8+ T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2X4 Receptor-Dependent Proinflammatory and Migratory Responses - J Am Soc NephrolBackground The mechanisms regulating CD8+ T cell migration to nonlymphoid tissue during inflammation have not been fully elucidated, and the migratory properties of effector memory CD8+ T cells that re-express CD45RA (TEMRA CD8+ T cells) remain unclear, despite their roles in autoimmune (...)
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Background Children with glomerular disease have unique risk factors for compromised bone health. Studies addressing skeletal complications in this population are lacking. Methods This retrospective cohort study utilized data from PEDSnet, a national network of pediatric health systems with (...)
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19:00A Population-Based Analysis of the Risk of Glomerular Disease Relapse after COVID-19 Vaccination - J Am Soc NephrolBackground Although case reports have described relapses of glomerular disease after COVID-19 vaccination, evidence of a true association is lacking. In this population-level analysis, we sought to determine relative and absolute risks of glomerular disease relapse after COVID-19 vaccination. (...)
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19:00Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance - J Am Soc NephrolBackground CKD is characterized by a sustained proinflammatory response of the immune system, promoting hypertension and cardiovascular disease. The underlying mechanisms are incompletely understood but may be linked to gut dysbiosis. Dysbiosis has been described in adults with CKD; however, (...)
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19:00Expansion of Escherichia-Shigella in Gut Is Associated with the Onset and Response to Immunosuppressive Therapy of IgA Nephropathy - J Am Soc NephrolBackground Gut dysbiosis is postulated to participate in the pathogenesis of IgA nephropathy (IgAN). However, the key bacterial taxa closely associated with IgAN onset and treatment response have not been identified. Methods We recruited 127 patients with IgAN who were treatment naive and 127 (...)
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19:00HLA-DQ Mismatches Lead to More Unacceptable Antigens, Greater Sensitization, and Increased Disparities in Repeat Transplant Candidates - J Am Soc NephrolBackground In single-center studies, HLA-DQ mismatches stimulate the most pathogenic donor-specific antibodies. However, because of limitations of transplant registries, this cannot be directly confirmed with registry-based analyses. Methods We evaluated patients in the Scientific Registry of (...)
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19:00Banff Human Organ Transplant Transcripts Correlate with Renal Allograft Pathology and Outcome: Importance of Capillaritis and Subpathologic Rejection - J Am Soc NephrolBackground To seek insights into the pathogenesis of chronic active antibody–mediated rejection (CAMR), we performed mRNA analysis and correlated transcripts with pathologic component scores and graft outcomes. Methods We utilized the NanoString nCounter platform and the Banff Human Organ (...)
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29 November
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Negative Modulation of B Cell Activation by Melanocortin 1 Receptor Signaling Protects against Membranous Nephropathy - J Am Soc NephrolBackground Emerging evidence suggests that the pituitary neuropeptide melanocortins—specifically, adrenocorticotropic hormone—offer a novel nonsteroidogenic therapeutic modality for membranous nephropathy (MN). However, the mechanism(s) of action remains elusive. Methods To investigate whether (...) -- Basic Research – Pharmacology and Therapeutic Development
23 November
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Reproductive Healthcare Is a Key Component of Comprehensive Care for Adolescents with CKD - J Am Soc NephrolNo abstract available -- Perspective
22 November
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs - J Am Soc NephrolBackground About 40 disease genes have been described to date for isolated CAKUT, the most common cause of childhood chronic kidney disease. However, these genes account for only 20% of cases. ARHGEF6, a guanine nucleotide exchange factor that is implicated in biologic processes such as cell (...) -- Basic Research
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Background Intact expression of podocyte histone deacetylases (HDAC) during development is essential for maintaining a normal glomerular filtration barrier because of its role in modulating DNA damage and preventing premature senescence. Methods Germline podocyte-specific Hdac1 and 2 (Hdac1/2) (...) -- Basic Research – Glomerulonephritis and Interstitial Nephritis
17 November
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Treatment Effect of the SGLT2 Inhibitor Empagliflozin on Chronic Syndrome of Inappropriate Antidiuresis: Results of a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial - J Am Soc NephrolBackground The syndrome of inappropriate antidiuresis (SIAD) is characterized by a reduction of free water excretion with consecutive hypotonic hyponatremia and is therefore challenging to treat. The sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin promotes osmotic diuresis via (...) -- Clinical Research: Acid Base and Electrolyte Disorders
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07:00Changes in Glomerular Volume, Sclerosis, and Ischemia at 5 Years after Kidney Transplantation: Incidence and Correlation with Late Graft Failure - J Am Soc NephrolBackground Histology can provide insight into the biology of renal allograft loss. However, studies are lacking that use quantitative morphometry to simultaneously assess changes in mean glomerular volume and in the percentages of globally sclerosed glomeruli (GSG) and ischemic-appearing (...) -- Clinical Research: Transplantation
11 November
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00National Projections for Clinical Implications of Race-Free Creatinine-Based GFR Estimating Equations - J Am Soc NephrolBackground The National Kidney Foundation and American Society of Nephrology Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease recently recommended a new race-free creatinine-based equation for eGFR. The effect on recommended clinical care across race and ethnicity (...) -- Clinical Epidemiology: Chronic Kidney Disease
9 November
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Long-Read Sequencing Identifies Novel Pathogenic Intronic Variants in Gitelman Syndrome - J Am Soc NephrolBackground Gitelman syndrome is a salt-losing tubulopathy characterized by hypokalemic alkalosis and hypomagnesemia. It is caused by homozygous recessive or compound heterozygous pathogenic variants in SLC12A3 , which encodes the Na+-Cl? cotransporter (NCC). In up to 10% of patients with (...) -- Clinical Research: Genetic Disease of the Kidney
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Background FSGS is the final common pathway to nephron loss in most forms of severe or progressive glomerular injury. Although podocyte injury initiates FSGS, parietal epithelial cells (PECs) are the main effectors. Because PDGF takes part in fibrotic processes, we hypothesized that the ligand (...) -- Basic Research: Chronic Kidney Disease
7 November
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Can Kidney Organoid Xenografts Accelerate Therapeutic Development for Genetic Kidney Disorders? - J Am Soc NephrolA number of genetic kidney diseases can now be replicated experimentally, using kidney organoids generated from human pluripotent stem cells. This methodology holds great potential for drug discovery. Under in vitro conditions, however, kidney organoids remain developmentally immature, develop (...) -- Review
31 October
J Am Soc Nephrol https://jasn.asnjournals.org/
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06:00Translation Rescue by Targeting Ppp1r15a through Its Upstream Open Reading Frame in Sepsis-Induced Acute Kidney Injury in a Murine Model - J Am Soc NephrolBackground Translation shutdown is a hallmark of late-phase, sepsis-induced kidney injury. Methods for controlling protein synthesis in the kidney are limited. Reversing translation shutdown requires dephosphorylation of the eukaryotic initiation factor 2 (eIF2) subunit eIF2?; this is mediated (...) -- Original Article: Basic Research
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18:00Hypoxia-Inducible Factor-Prolyl Hydroxyl Domain Inhibitors: From Theoretical Superiority to Clinical Noninferiority Compared with Current ESAs? - J Am Soc NephrolAnemia is a common complication of chronic kidney disease; it is mainly treated with erythropoiesis-stimulating agents (ESAs) and iron. Experimental studies extensively investigated the mechanisms involved in the body’s response to hypoxia and led to the discovery of the hypoxia-inducible factor (...)
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18:00Steroid-Resistant Nephrotic Syndrome-Associated MYO1E Mutations Have Differential Effects on Myosin 1e Localization, Dynamics, and Activity - J Am Soc NephrolBackground Myo1e is a nonmuscle motor protein enriched in podocytes. Mutations in MYO1E are associated with steroid-resistant nephrotic syndrome (SRNS). Most of the MYO1E variants identified by genomic sequencing have not been functionally characterized. Here, we set out to analyze two (...)
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18:00A Novel Mouse Model of Idiopathic Nephrotic Syndrome Induced by Immunization with the Podocyte Protein Crb2 - J Am Soc NephrolBackground The cause of podocyte injury in idiopathic nephrotic syndrome (INS) remains unknown. Although recent evidence points to the role of B cells and autoimmunity, the lack of animal models mediated by autoimmunity limits further research. We aimed to establish a mouse model mimicking (...)
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18:00Data-Driven Chronic Allograft Phenotypes: A Novel and Validated Complement for Histologic Assessment of Kidney Transplant Biopsies - J Am Soc NephrolBackground No validated system currently exists to realistically characterize the chronic pathology of kidney transplants that represents the dynamic disease process and spectrum of disease severity. We sought to develop and validate a tool to describe chronicity and severity of renal (...)
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18:00Early Molecular Events Mediating Loss of Aquaporin-2 during Ureteral Obstruction in Rats - J Am Soc NephrolBackground Ureteral obstruction is marked by disappearance of the vasopressin-dependent water channel aquaporin-2 (AQP2) in the renal collecting duct and polyuria upon reversal. Most studies of unilateral ureteral obstruction (UUO) models have examined late time points, obscuring the early (...)
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18:00A Comparison of US Medicare Expenditures for Hemodialysis and Peritoneal Dialysis - J Am Soc NephrolBackground Observations that peritoneal dialysis (PD) may be an effective, lower-cost alternative to hemodialysis for the treatment of ESKD have led to policies encouraging PD and subsequent increases in its use in the United States. Methods In a retrospective cohort analysis of Medicare (...)
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18:00Nuclear Magnetic Resonance Metabolomic Profiling and Urine Chemistries in Incident Kidney Stone Formers Compared with Controls - J Am Soc NephrolBackground The urine metabolites and chemistries that contribute to kidney stone formation are not fully understood. This study examined differences between the urine metabolic and chemistries profiles of first-time stone formers and controls. Methods High-resolution 1H-nuclear magnetic (...)
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18:00Differences in Phosphate and Parathyroid Hormone Concentrations over the Day among Patients on Hemodialysis - J Am Soc NephrolBackground Elevated serum phosphate and parathyroid hormone (PTH) concentrations are associated with cardiovascular events, bone disease, and mortality in patients on maintenance hemodialysis. Although circadian changes are known in people with CKD, it is unknown whether differences occur in (...)
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18:00Correlates and Consequences of an Acute Change in eGFR in Response to the SGLT2 Inhibitor Dapagliflozin in Patients with CKD - J Am Soc NephrolBackground Dapagliflozin reduces kidney failure risk in patients with CKD but can result in a reversible acute reduction in eGFR upon treatment initiation. Determinants of this eGFR reduction and its associations with efficacy and safety outcomes are unknown. Methods The DAPA-CKD trial (...)
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18:00Blood Transcriptomes of SARS-CoV-2-Infected Kidney Transplant Recipients Associated with Immune Insufficiency Proportionate to Severity - J Am Soc NephrolBackground Among patients with COVID-19, kidney transplant recipients (KTRs) have poor outcomes compared with non-KTRs. To provide insight into management of immunosuppression during acute illness, we studied immune signatures from the peripheral blood during and after COVID-19 infection from (...)
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27 October
J Am Soc Nephrol https://jasn.asnjournals.org/
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Background: Genomic Disorders (GDs) are associated with many comorbid outcomes, including chronic kidney disease (CKD). Identification of GDs has diagnostic utility. Background: Genomic Disorders (GDs) are associated with many comorbid outcomes, including chronic kidney disease (CKD). (...) -- Original Article - Basic Research
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07:00The New Kidney-Focused Companies: A Privatized Approach to Value-Based Care and Addressing Social Determinants of Health - J Am Soc NephrolNo abstract available -- Perspective
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Background In March 2021, the United States implemented a new kidney allocation system (KAS250) for deceased donor kidney transplantation (DDKT), which eliminated the donation service area-based allocation and replaced it with a system on the basis of distance from donor hospital to transplant (...) -- Clinical Epidemiology: Transplantation
26 October
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Glucose/Fructose Delivery to the Distal Nephron Activates the Sodium-Chloride Cotransporter via the Calcium-Sensing Receptor - J Am Soc NephrolBackground The calcium-sensing receptor (CaSR) in the distal convoluted tubule (DCT) activates the NaCl cotransporter (NCC). Glucose acts as a positive allosteric modulator of the CaSR. Under physiologic conditions, no glucose is delivered to the DCT, and fructose delivery depends on (...) -- Basic Research: Acid Base and Electrolyte Disorders
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Background: Testican-2 was recently identified as a podocyte-derived protein that is released into circulation by the kidneys and is positively correlated with estimated glomerular filtration rate (eGFR) and eGFR slope. However, whether higher testican-2 levels are associated with lower risk of (...) -- Original Article - Clinical Research
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07:00Distinguishing among HCO3?, CO3=, and H+ as Substrates of Proteins That Appear To Be “Bicarbonate” Transporters - J Am Soc NephrolBackground Differentiating among HCO3?, CO3=, and H+ movements across membranes has long seemed impossible. We now seek to discriminate unambiguously among three alternate mechanisms: the inward flux of 2 HCO3? (mechanism 1), the inward flux of 1 CO3= (mechanism 2), and the CO2/HCO3?-stimulated (...) -- Basic Research: Acid Base and Electrolyte Disorders
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No abstract available -- Editorial
25 October
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Basic Requirements for Improving Home Dialysis Utilization: Specialty Nephrology Care and Pre-End Stage Kidney Disease Education - J Am Soc NephrolNo abstract available -- Invited Feature
21 October
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00XBP1 Activation Reduces Severity of Polycystic Kidney Disease due to a Nontruncating Polycystin-1 Mutation in Mice - J Am Soc NephrolBackground Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in Pkd1 and Pkd2. They encode the polytopic integral membrane proteins polycystin-1 (PC1) and polycystin-2 (PC2), respectively, which are expressed on primary cilia. Formation of kidney cysts in ADPKD starts (...) -- Original Article: Basic Research
19 October
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00A New DDX58 Pathogenic Variant Causes Lupus Nephritis Due to RIG-I Hyperactivation and its Clinical Implication - J Am Soc NephrolBackground: Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus, with heterogeneous phenotypes and different responses to therapy. Identifying genetic causes of LN can facilitate more individual treatment strategies. Background: Lupus nephritis (LN) is (...) -- Original Article - Basic Research
5 October
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Genetic Variants of the COL4A3, COL4A4, and COL4A5 Genes Contribute to Thinned Glomerular Basement Membrane Lesions in Sporadic IgA Nephropathy Patients - J Am Soc NephrolBackground Thinned glomerular basement membrane (tGBM) lesions are not uncommon in IgA nephropathy (IgAN). Type IV collagen—built of ?3, ?4, and ?5 chains, encoded by COL4A3/COL4A4/COL4A5 genes—is the major component of glomerular basement membrane (GBM). In recent years, mutations in type IV (...) -- Clinical Research
4 October
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients - J Am Soc NephrolBackground: Ischemia-reperfusion (IR) of a kidney transplant (KTx) upregulates tumor necrosis factor alpha (TNF) production that amplifies allograft inflammation and may negatively impact transplant outcomes. Background: Ischemia-reperfusion (IR) of a kidney transplant (KTx) upregulates tumor (...) -- Original Article - Clinical Research
30 September
J Am Soc Nephrol https://jasn.asnjournals.org/
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Background Primary membranous nephropathy (MN) is caused by circulating autoantibodies binding to antigens on the podocyte surface. PLA2R1 is the main target antigen in 70%–80% of cases, but the pathogenesis is unresolved in 10%–15% of patients. Methods We used native western blotting to (...)
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19:00SARS-CoV-2 Infection during the Omicron Surge among Patients Receiving Dialysis: The Role of Circulating Receptor-Binding Domain Antibodies and Vaccine Doses - J Am Soc NephrolBackground It is unclear whether circulating antibody levels conferred protection against SARS-CoV-2 infection among patients receiving dialysis during the Omicron-dominant period. Methods We followed monthly semiquantitative SARS-CoV-2 RBD IgG index values in a randomly selected nationwide (...)
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19:00Carbamylation of Integrin alphaIIbbeta3: The Mechanistic Link to Platelet Dysfunction in ESKD - J Am Soc NephrolBackground Bleeding diatheses, common among patients with ESKD, can lead to serious complications, particularly during invasive procedures. Chronic urea overload significantly increases cyanate concentrations in patients with ESKD, leading to carbamylation, an irreversible modification of (...)
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19:00Phloretin Improves Ultrafiltration and Reduces Glucose Absorption during Peritoneal Dialysis in Rats - J Am Soc NephrolBackground Harmful glucose exposure and absorption remain major limitations of peritoneal dialysis (PD). We previously showed that inhibition of sodium glucose cotransporter 2 did not affect glucose transport during PD in rats. However, more recently, we found that phlorizin, a dual blocker of (...)
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19:00Dapagliflozin Prevents Kidney Glycogen Accumulation and Improves Renal Proximal Tubule Cell Functions in a Mouse Model of Glycogen Storage Disease Type 1b - J Am Soc NephrolBackground Mutations in SLC37A4, which encodes the intracellular glucose transporter G6PT, cause the rare glycogen storage disease type 1b (GSD1b). A long-term consequence of GSD1b is kidney failure, which requires KRT. The main protein markers of proximal tubule function, including NaPi2A, (...)
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19:00Blocking CCL8-CCR8-Mediated Early Allograft Inflammation Improves Kidney Transplant Function - J Am Soc NephrolBackground In kidney transplantation, early allograft inflammation impairs long-term allograft function. However, precise mediators of early kidney allograft inflammation are unclear, making it challenging to design therapeutic interventions. Methods We used an allogeneic murine kidney (...)
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Background CKD is more prevalent in women, but more men receive kidney replacement therapy for kidney failure. This apparent contradiction is not well understood. Methods We investigated sex differences in the loss of kidney function and whether any sex disparities could be explained by (...)
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19:00Sex Differences in the Recognition, Monitoring, and Management of CKD in Health Care: An Observational Cohort Study - J Am Soc NephrolIntroduction Reported sex differences in the etiology, population prevalence, progression rates, and health outcomes of people with CKD may be explained by differences in health care. Methods We evaluated sex as the variable of interest in a health care–based study of adults (n=227,847) with (...)
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19:00Markers of Kidney Tubular Secretion and Risk of Adverse Events in SPRINT Participants with CKD - J Am Soc NephrolBackground Kidney tubular secretion is an essential mechanism for clearing many common antihypertensive drugs and other metabolites and toxins. It is unknown whether novel measures of tubular secretion are associated with adverse events (AEs) during hypertension treatment. Methods Among 2089 (...)
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19:00Prognostic Implications of a Morphometric Evaluation for Chronic Changes on All Diagnostic Native Kidney Biopsies - J Am Soc NephrolBackground Semiquantitative visual inspection for glomerulosclerosis, interstitial fibrosis, and arteriosclerosis is often used to assess chronic changes in native kidney biopsies. Morphometric evaluation of these and other chronic changes may improve the prognostic assessment. Methods We (...)
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Background Compared with the general Medicare population, patients with ESKD have worse quality metrics for end-of-life care, including a higher percentage experiencing hospitalizations and in-hospital deaths and a lower percentage referred to hospice. We developed a Concurrent Hospice and (...)
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27 September
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Kidney Organoids Generated Using an Allelic Series of NPHS2 Point Variants Reveal Distinct Intracellular Podocin Mistrafficking - J Am Soc NephrolBackground:NPHS2 variants are the most common cause of steroid-resistant nephrotic syndrome in >1-month-old children. Missense NPHS2 variants were reported to cause mistrafficking of the encoded protein, PODOCIN, but this conclusion was based on overexpression in some non-podocyte cell lines. (...) -- Original Article - Basic Research
22 September
J Am Soc Nephrol https://jasn.asnjournals.org/
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07:00Induction of Long-lasting Regulatory B Lymphocytes by Modified Immune Cells in Kidney Transplant Recipients - J Am Soc NephrolBackground We recently demonstrated that donor-derived modified immune cells (MICs)—PBMCs that acquire immunosuppressive properties after a brief treatment— induced specific immunosuppression against the allogeneic donor when administered prior to kidney transplantation. We found an up to 68-fold (...) -- Original Article - Clinical Research
31 August
J Am Soc Nephrol https://jasn.asnjournals.org/
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The glomerular vascular pole is the gate for the afferent and efferent arterioles and mesangial cells and a frequent location of peripolar cells with an unclear function. It has been studied in definitive detail for >30 years, and functionally interrogated in the context of signal (...)
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19:00Systematic Review and Meta-Analysis of Plasma and Urine Biomarkers for CKD Outcomes - J Am Soc NephrolBackground Sensitive and specific biomarkers are needed to provide better biologic insight into the risk of incident and progressive CKD. However, studies have been limited by sample size and design heterogeneity. Methods In this assessment of the prognostic value of preclinical plasma and (...)
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19:00Kidney Failure Alters Parathyroid Pin1 Phosphorylation and Parathyroid Hormone mRNA-Binding Proteins, Leading to Secondary Hyperparathyroidism - J Am Soc NephrolBackground Secondary hyperparathyroidism (SHP) is a common complication of CKD that increases morbidity and mortality. In experimental SHP, increased parathyroid hormone (PTH) expression is due to enhanced PTH mRNA stability, mediated by changes in its interaction with stabilizing AUF1 and (...)
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19:00Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney - J Am Soc NephrolBackground The embryonic renal stroma consists of multiple molecularly distinct cell subpopulations, the functional significance of which is largely unknown. Previous work has demonstrated that the transcription factors YAP and TAZ play roles in the development and morphogenesis of the (...)
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19:00Nuclear Condensation of CDYL Links Histone Crotonylation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease - J Am Soc NephrolBackground Emerging evidence indicates that epigenetic modulation of gene expression plays a key role in the progression of autosomal dominant polycystic kidney disease (ADPKD). However, the molecular basis for how the altered epigenome modulates transcriptional responses, and thereby disease (...)
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19:00KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency-Related Polycystic Kidney Disease - J Am Soc NephrolBackground Ciliogenesis-associated kinase 1 (CILK1) is a ciliary gene that localizes in primary cilia and regulates ciliary transport. Mutations in CILK1 cause various ciliopathies. However, the pathogenesis of CILK1-deficient kidney disease is unknown. Methods To examine whether CILK1 (...)
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19:00Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy - J Am Soc NephrolBackground The complement system is highly activated in primary membranous nephropathy (MN). Identifying the complement components that damage podocytes has important therapeutic implications. This study investigated the role of C3a and the C3a receptor (C3aR) in the pathogenesis of MN. (...)
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Background Hurricanes are severe weather events that can disrupt power, water, and transportation systems. These disruptions may be deadly for patients requiring maintenance dialysis. We hypothesized that the mortality risk among patients requiring maintenance dialysis would be increased in (...)
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Background Despite reports of hematuria and proteinuria with rosuvastatin use at the time of its approval by the US Food and Drug Association (FDA), little postmarketing surveillance exists to assess real-world risk. Current labeling suggests dose reduction (maximum daily dose of 10 mg) for (...)
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Background Observational studies suggest that adequate dietary potassium intake (90–120 mmol/day) may be renoprotective, but the effects of increasing dietary potassium and the risk of hyperkalemia are unknown. Methods This is a prespecified analysis of the run-in phase of a clinical trial in (...)
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Background Greenhouse gas emissions from hemodialysis treatment in the United States have not been quantified. In addition, no previous studies have examined how much emissions vary across facilities, treatments, and emission contributors. Methods To estimate the magnitude and sources of (...)
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30 June
J Am Soc Nephrol https://jasn.asnjournals.org/
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19:00Transplantation Mediates Much of the Racial Disparity in Survival from Childhood-Onset Kidney Failure - J Am Soc NephrolBackground The role of kidney transplantation in differential survival in Black and White patients with childhood-onset kidney failure is unexplored. Methods We analyzed 30-year cohort data of children beginning RRT before 18 years of age between January 1980 and December 2017 (n=28,337) in (...)
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19:00Maturation of GFR in Term-Born Neonates: An Individual Participant Data Meta-Analysis - J Am Soc NephrolBackground The evidence from individual studies to support the maturational pattern of GFR in healthy, term-born neonates is inconclusive. We performed an individual participant data (IPD) meta-analysis of reported measured GFR (mGFR) data, aiming to establish neonatal GFR reference values. (...)
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19:00A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection - J Am Soc NephrolBackground Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) uses full-length angiotensin converting enzyme 2 (ACE2) as a main receptor to enter target cells. The goal of this study was to demonstrate the preclinical efficacy of a novel soluble ACE2 protein with increased (...)
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Background We reasoned that unraveling the dynamic changes in accessibility of genomic regulatory elements and gene expression at single-cell resolution will inform the basic mechanisms of nephrogenesis. Methods We performed single-cell ATAC-seq and RNA-seq both individually (singleomes; (...)
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19:00Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells - J Am Soc NephrolBackground Impaired mineral ion metabolism is a hallmark of CKD–metabolic bone disorder. It can lead to pathologic vascular calcification and is associated with an increased risk of cardiovascular mortality. Loss of calcium-sensing receptor (CaSR) expression in vascular smooth muscle cells (...)
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19:00Brief Early Life Angiotensin-Converting Enzyme Inhibition Offers Renoprotection in Sheep with a Solitary Functioning Kidney at 8 Months of Age - J Am Soc NephrolBackground Children born with a solitary functioning kidney (SFK) are predisposed to develop hypertension and kidney injury. Glomerular hyperfiltration and hypertrophy contribute to the pathophysiology of kidney injury. Angiotensin-converting enzyme inhibition (ACEi) can mitigate (...)
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Background Adult progenitor cells presumably demonstrate clonogenicity, self-renewal, and multipotentiality, and can regenerate cells under various conditions. Definitive evidence demonstrating the existence of such progenitor cells in adult mammalian kidneys is lacking. Method We performed (...)
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19:00The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia - J Am Soc NephrolBackground Insulin resistance, hypertension, hyperuricemia, and hypercholesterolemia are hypothesized to be important intermediates in the relationship between excess body weight and CKD risk. However, the magnitude of the total effect of excess body weight on ESKD mediated through these four (...)
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19:00Association of Proximal Tubular Secretory Clearance with Long-Term Decline in Cognitive Function - J Am Soc NephrolBackground People with chronic kidney disease (CKD) are at high risk for cognitive impairment and progressive cognitive decline. Retention of protein-bound organic solutes that are normally removed by tubular secretion is hypothesized to contribute to cognitive impairment in CKD. Methods We (...)
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19:00Hypomagnesemia, Hypocalcemia, and Tubulointerstitial Nephropathy Caused by Claudin-16 Autoantibodies - J Am Soc NephrolBackground Chronic hypomagnesemia is commonly due to diarrhea, alcoholism, and drugs. More rarely, it is caused by genetic defects in the effectors of renal magnesium reabsorption. Methods In an adult patient with acquired severe hypomagnesemia, hypocalcemia, tubulointerstitial nephropathy, (...)
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19:00Kidney Biopsy Features Most Predictive of Clinical Outcomes in the Spectrum of Minimal Change Disease and Focal Segmental Glomerulosclerosis - J Am Soc NephrolBackground Heterogeneity in disease course and treatment response among patients with MCD/FSGS necessitates a granular evaluation of kidney tissue features. This study aimed to identify histologic and ultrastructural descriptors of structural changes most predictive of clinical outcomes in the (...)
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31 May
J Am Soc Nephrol https://jasn.asnjournals.org/
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The United States Department of Health and Human Services launched the Advancing American Kidney Health Initiative in 2019, which included a goal of transforming dialysis care from an in-center to a largely home-based dialysis program. A substantial motivator for this transition is the (...)
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19:00Empagliflozin Changes Urine Supersaturation by Decreasing pH and Increasing Citrate - J Am Soc NephrolClinical Trial registry name and registration number: Empagliflozin and Renal Oxygenation in Healthy Volunteers (EMPA-REIN), NCT03093103
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Background After kidney injury, macrophages transition from initial proinflammatory activation to a proreparative phenotype characterized by expression of arginase-1 (Arg1), mannose receptor 1 (Mrc1), and macrophage scavenger receptor 1 (Msr1). The mechanism by which these alternatively (...)
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19:00Protein Kinase A Downregulation Delays the Development and Progression of Polycystic Kidney Disease - J Am Soc NephrolBackground Upregulation of cAMP-dependent and cAMP-independent PKA signaling is thought to promote cystogenesis in polycystic kidney disease (PKD). PKA-I regulatory subunit RIα is increased in kidneys of orthologous mouse models. Kidney-specific knockout of RIα upregulates PKA (...)
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Background In recent years, many studies have focused on the intestinal environment to elucidate pathogenesis of various diseases, including kidney diseases. Impairment of the intestinal barrier function, the "leaky gut," reportedly contributes to pathologic processes in some disorders. (...)
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19:00Reduced Glomerular Filtration in Diabetes Is Attributable to Loss of Density and Increased Resistance of Glomerular Endothelial Cell Fenestrations - J Am Soc NephrolBackground Glomerular endothelial cell (GEnC) fenestrations are recognized as an essential component of the glomerular filtration barrier, yet little is known about how they are regulated and their role in disease. Methods We comprehensively characterized GEnC fenestral and functional renal (...)
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19:00Factor H-Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy - J Am Soc NephrolBackground C3 glomerulopathy (C3G) is a heterogeneous group of chronic renal diseases characterized predominantly by glomerular C3 deposition and complement dysregulation. Mutations in factor H–related (FHR) proteins resulting in duplicated dimerization domains are prototypical of C3G, although (...)
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Background The pathophysiology of AKI during tumor lysis syndrome (TLS) is not well understood due to the paucity of data. We aimed to decipher crystal-dependent and crystal-independent mechanisms of TLS-induced AKI. Methods Crystalluria, plasma cytokine levels, and extracellular histones (...)
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19:00Acute Kidney Injury Associates with Long-Term Increases in Plasma TNFR1, TNFR2, and KIM-1: Findings from the CRIC Study - J Am Soc NephrolBackground Some markers of inflammation—TNF receptors 1 and 2 (TNFR1 and TNFR2)—are independently associated with progressive CKD, as is a marker of proximal tubule injury, kidney injury molecule 1 (KIM-1). However, whether an episode of hospitalized AKI may cause long-term changes in these (...)
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19:00Immunosuppressant Medication Use in Patients with Kidney Allograft Failure: A Prospective Multicenter Canadian Cohort Study - J Am Soc NephrolBackground Patients with kidney transplant failure have a high risk of hospitalization and death due to infection. The optimal use of immunosuppressants after transplant failure remains uncertain and clinical practice varies widely. Methods This prospective cohort study enrolled patients (...)
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19:00Long-Term Efficacy and Safety of Repeated Rituximab to Maintain Remission in Idiopathic Childhood Nephrotic Syndrome: An International Study - J Am Soc NephrolBackground Long-term outcomes after multiple courses of rituximab among children with frequently relapsing, steroid-dependent nephrotic syndrome (FRSDNS) are unknown. Methods A retrospective cohort study at 16 pediatric nephrology centers from ten countries in Asia, Europe, and North America (...)
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Background Molecular characterization of nephropathies may facilitate pathophysiologic insight, development of targeted therapeutics, and transcriptome-based disease classification. Although membranous nephropathy (MN) is a common cause of adult-onset nephrotic syndrome, the molecular pathways (...)
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29 April
J Am Soc Nephrol https://jasn.asnjournals.org/
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19:00DGAT2 Inhibition Potentiates Lipid Droplet Formation To Reduce Cytotoxicity in APOL1 Kidney Risk Variants - J Am Soc NephrolBackground Two variants in the gene encoding apolipoprotein L1 (APOL1) that are highly associated with African ancestry are major contributors to the large racial disparity in rates of human kidney disease. We previously demonstrated that recruitment of APOL1 risk variants G1 and G2 from the (...)
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19:00Galactose-Deficient IgA1 B cells in the Circulation of IgA Nephropathy Patients Carry Preferentially Lambda Light Chains and Mucosal Homing Receptors - J Am Soc NephrolBackground IgA nephropathy (IgAN) primary glomerulonephritis is characterized by the deposition of circulating immune complexes composed of polymeric IgA1 molecules with altered O-glycans (Gd-IgA1) and anti-glycan antibodies in the kidney mesangium. The mesangial IgA deposits and serum IgA1 (...)
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19:00Chimeric Fusion between Clostridium Ramosum IgA Protease and IgG Fc Provides Long-Lasting Clearance of IgA Deposits in Mouse Models of IgA Nephropathy - J Am Soc NephrolBackground IgA nephropathy is a common primary glomerulonephritis caused by mesangial deposition of poly-IgA complexes. The disease follows a variable course of clinical progression, with a high risk of kidney failure. Although no specific therapy is available, enzymatic strategies to clear (...)
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Background The ANCA autoantigens proteinase 3 (PR3) and myeloperoxidase (MPO) are exclusively expressed by neutrophils and monocytes. ANCA-mediated activation of these cells is the key driver of the vascular injury process in ANCA-associated vasculitis (AAV), and neutrophil serine proteases (...)
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19:00Serum Protein Exposure Activates a Core Regulatory Program Driving Human Proximal Tubule Injury - J Am Soc NephrolBackground The kidneys efficiently filter waste products while retaining serum proteins in the circulation. However, numerous diseases compromise this barrier function, resulting in spillage of serum proteins into the urine (proteinuria). Some studies of glomerular filtration suggest that (...)
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19:00Interleukin-33 Exacerbates IgA Glomerulonephritis in Transgenic Mice Overexpressing B Cell Activating Factor - J Am Soc NephrolBackground The cytokine IL-33 is an activator of innate lymphoid cells 2 (ILC2s) in innate immunity and allergic inflammation. B cell activating factor (BAFF) plays a central role in B cell proliferation and differentiation, and high levels of this protein cause excess antibody production, (...)
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19:00Association of Clonal Hematopoiesis of Indeterminate Potential with Worse Kidney Function and Anemia in Two Cohorts of Patients with Advanced Chronic Kidney Disease - J Am Soc NephrolBackground Clonal hematopoiesis of indeterminate potential (CHIP) is an inflammatory premalignant disorder resulting from acquired genetic mutations in hematopoietic stem cells. This condition is common in aging populations and associated with cardiovascular morbidity and overall mortality, (...)
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19:00Longitudinal TNFR1 and TNFR2 and Kidney Outcomes: Results from AASK and VA NEPHRON-D - J Am Soc NephrolBackground Higher baseline levels of soluble TNF receptors (TNFR1 and TNFR2) have been associated with progressive CKD. Whether longitudinal changes in these biomarkers of inflammation are also associated with worse kidney outcomes has been less studied. Methods We evaluated associations of (...)
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19:00Interventions To Attenuate Vascular Calcification Progression in Chronic Kidney Disease: A Systematic Review of Clinical Trials - J Am Soc NephrolBackground Vascular calcification is associated with cardiovascular morbidity and mortality in people with CKD. Evidence-based interventions that may attenuate its progression in CKD remain uncertain. Methods We conducted a systematic review of prospective clinical trials of interventions to (...)
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19:00Hematopoietic Stem Cell Transplant-Membranous Nephropathy Is Associated with Protocadherin FAT1 - J Am Soc NephrolBackground Membranous nephropathy (MN) is a common cause of proteinuria in patients receiving a hematopoietic stem cell transplant (HSCT). The target antigen in HSCT-associated MN is unknown. Methods We performed laser microdissection and tandem mass spectrometry (MS/MS) of glomeruli from 250 (...)
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31 March
J Am Soc Nephrol https://jasn.asnjournals.org/
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19:00The Impact of Vaccination on Incidence and Outcomes of SARS-CoV-2 Infection in Patients with Kidney Failure in Scotland - J Am Soc NephrolBackground Patients with kidney failure requiring KRT are at high risk of complications and death following SARS-CoV-2 infection, with variable antibody responses to vaccination reported. We investigated the effects of COVID-19 vaccination on the incidence of infection, hospitalization, and (...)
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19:00Comparative Effectiveness of mRNA-based BNT162b2 Vaccine versus Adenovirus Vector-Based Ad26.COV2.S Vaccine for the Prevention of COVID-19 among Dialysis Patients - J Am Soc NephrolBackground Studies have demonstrated that mRNA-based SARS-CoV-2 vaccines are highly effective among patients on dialysis. Because individual vaccines may be differentially available or acceptable to patients, it is important to understand comparative effectiveness relative to other vaccines, (...)
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19:00Claudin-10a Deficiency Shifts Proximal Tubular Cl- Permeability to Cation Selectivity via Claudin-2 Redistribution - J Am Soc NephrolBackground The tight junction proteins claudin-2 and claudin-10a form paracellular cation and anion channels, respectively, and are expressed in the proximal tubule. However, the physiologic role of claudin-10a in the kidney has been unclear. Methods To investigate the physiologic role of (...)
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19:00A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome - J Am Soc NephrolBackground Alport syndrome is a genetic disorder characterized by a defective glomerular basement membrane, tubulointerstitial fibrosis, inflammation, and progressive renal failure. IL-11 was recently implicated in fibrotic kidney disease, but its role in Alport syndrome is unknown. Methods (...)
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Background The endocytic reabsorption of proteins in the proximal tubule requires a complex machinery and defects can lead to tubular proteinuria. The precise mechanisms of endocytosis and processing of receptors and cargo are incompletely understood. EHD1 belongs to a family of proteins (...)
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19:00A Comprehensive Immune Cell Atlas of Cystic Kidney Disease Reveals the Involvement of Adaptive Immune Cells in Injury-Mediated Cyst Progression in Mice - J Am Soc NephrolBackground Inducible disruption of cilia-related genes in adult mice results in slowly progressive cystic disease, which can be greatly accelerated by renal injury. Methods To identify in an unbiased manner modifier cells that may be influencing the differential rate of cyst growth in injured (...)
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19:00Lipopolysaccharide Pretreatment Prevents Medullary Vascular Congestion following Renal Ischemia by Limiting Early Reperfusion of the Medullary Circulation - J Am Soc NephrolBackground Vascular congestion of the renal medulla—trapped red blood cells in the medullary microvasculature—is a hallmark finding at autopsy in patients with ischemic acute tubular necrosis. Despite this, the pathogenesis of vascular congestion is not well defined. Methods In this study, to (...)
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19:00alpha-Parvin Defines a Specific Integrin Adhesome to Maintain the Glomerular Filtration Barrier - J Am Soc NephrolBackground The cell-matrix adhesion between podocytes and the glomerular basement membrane is essential for the integrity of the kidney’s filtration barrier. Despite increasing knowledge about the complexity of integrin adhesion complexes, an understanding of the regulation of these protein (...)
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Introduction CKD is associated with alterations of tubular function. Renal gluconeogenesis is responsible for 40% of systemic gluconeogenesis during fasting, but how and why CKD affects this process and the repercussions of such regulation are unknown. Methods We used data on the renal (...)
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19:00Endopeptidase Cleavage of Anti-Glomerular Basement Membrane Antibodies in vivo in Severe Kidney Disease: An Open-Label Phase 2a Study - J Am Soc NephrolBackground The prognosis for kidney survival is poor in patients presenting with circulating anti–glomerular basement membrane (GBM) antibodies and severe kidney injury. It is unknown if treatment with an endopeptidase that cleaves circulating and kidney bound IgG can alter the prognosis. (...)
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19:00Vaccine Effectiveness Against SARS-CoV-2 Infection and Severe Outcomes in the Maintenance Dialysis Population in Ontario, Canada - J Am Soc NephrolBackground Vaccination studies in the hemodialysis population have demonstrated decreased antibody response compared with healthy controls, but vaccine effectiveness for preventing SARS-CoV-2 infection and severe disease is undetermined. Methods We conducted a retrospective cohort study in (...)
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19:00Roxadustat Versus Epoetin Alfa for Treating Anemia in Patients with Chronic Kidney Disease on Dialysis: Results from the Randomized Phase 3 ROCKIES Study - J Am Soc NephrolBackground Concerns regarding cardiovascular safety with current treatments for anemia in patients with dialysis-dependent (DD)-CKD have encouraged the development of alternatives. Roxadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, stimulates erythropoiesis by (...)
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28 February
J Am Soc Nephrol https://jasn.asnjournals.org/
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Understanding nephron loss is a primary strategy for preventing CKD progression. Death of renal tubular cells may occur by apoptosis during developmental and regenerative processes. However, during AKI, the transition of AKI to CKD, sepsis-associated AKI, and kidney transplantation ferroptosis (...)
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AKI affects approximately 13.3 million people around the world each year, causing CKD and/or mortality. The mammalian kidney cannot generate new nephrons after postnatal renal damage and regenerative therapies for AKI are not available. Human kidney tissue culture systems can complement animal (...)
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19:00Recurrence of Anti-Semaphorin 3B-Mediated Membranous Nephropathy after Kidney Transplantation - J Am Soc NephrolBackground Membranous nephropathy (MN) is rare in pediatric patients, although its diagnosis may be underestimated in children who are responsive to corticosteroid therapy prescribed for a suspicion of minimal change disease. It is most often associated with an autoimmune disease, (...)
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19:00Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin - J Am Soc NephrolBackground Uromodulin, the most abundant protein excreted in normal urine, plays major roles in kidney physiology and disease. The mechanisms regulating the urinary excretion of uromodulin remain essentially unknown. Methods We conducted a meta-analysis of genome-wide association studies for (...)
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19:00Vitamin C Deficiency Causes Cell Type-Specific Epigenetic Reprogramming and Acute Tubular Necrosis in a Mouse Model - J Am Soc NephrolBackground Vitamin C deficiency is found in patients with variable kidney diseases. However, the role of vitamin C as an epigenetic regulator in renal homeostasis and pathogenesis remains largely unknown. Methods We showed that vitamin C deficiency leads to acute tubular necrosis (ATN) using (...)
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19:00Gentamicin Inhibits Ca2+ Channel TRPV5 and Induces Calciuresis Independent of the Calcium-Sensing Receptor-Claudin-14 Pathway - J Am Soc NephrolBackground Treatment with the aminoglycoside antibiotic gentamicin can be associated with severe adverse effects, including renal Ca2+ wasting. The underlying mechanism is unknown but it has been proposed to involve activation of the Ca2+-sensing receptor (CaSR) in the thick ascending limb, (...)
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Background Endothelial cell injury is a common nidus of renal injury in patients and consistent with the high prevalence of AKI reported during the coronavirus disease 2019 pandemic. This cell type expresses integrin α5 (ITGA5), which is essential to the Tie2 signaling pathway. The (...)
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19:00Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice - J Am Soc NephrolBackground Mutations in the ubiquitin ligase scaffold protein Cullin 3 (CUL3) gene cause the disease familial hyperkalemic hypertension (FHHt). In the kidney, mutant CUL3 (CUL3-9) increases abundance of With-No-Lysine (K) Kinase 4 (WNK4), inappropriately activating sterile 20/SPS-1–related (...)
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19:00Risk Prediction Models for Atherosclerotic Cardiovascular Disease in Patients with Chronic Kidney Disease: The CRIC Study - J Am Soc NephrolBackground Individuals with CKD may be at high risk for atherosclerotic cardiovascular disease (ASCVD). However, there are no ASCVD risk prediction models developed in CKD populations to inform clinical care and prevention. Methods We developed and validated 10-year ASCVD risk prediction (...)
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19:00Angiopoietins as Prognostic Markers for Future Kidney Disease and Heart Failure Events after Acute Kidney Injury - J Am Soc NephrolBackground The mechanisms underlying long-term sequelae after AKI remain unclear. Vessel instability, an early response to endothelial injury, may reflect a shared mechanism and early trigger for CKD and heart failure. Methods To investigate whether plasma angiopoietins, markers of vessel (...)
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19:00Kidney Histopathology Can Predict Kidney Function in ANCA-Associated Vasculitides with Acute Kidney Injury Treated with Plasma Exchanges - J Am Soc NephrolBackground Data from the PEXIVAS trial challenged the role of plasma exchange (PLEX) in ANCA-associated vasculitides (AAV). We aimed to describe kidney biopsy from patients with AAV treated with PLEX, evaluate whether histopathologic findings could predict kidney function, and identify which (...)
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Background Knowledge of the effect of kidney transplantation on bone is limited and fragmentary. The aim of this study was to characterize the evolution of bone disease in the first post-transplant year. Methods We performed a prospective, observational cohort study in patients referred for (...)
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31 January
J Am Soc Nephrol https://jasn.asnjournals.org/
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19:00Secondary Immunodeficiency Related to Kidney Disease (SIDKD)--Definition, Unmet Need, and Mechanisms - J Am Soc NephrolKidney disease is a known risk factor for poor outcomes of COVID-19 and many other serious infections. Conversely, infection is the second most common cause of death in patients with kidney disease. However, little is known about the underlying secondary immunodeficiency related to kidney (...)
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19:00Spatially Resolved Transcriptomic Analysis of Acute Kidney Injury in a Female Murine Model - J Am Soc NephrolBackground Single-cell sequencing technologies have advanced our understanding of kidney biology and disease, but the loss of spatial information in these datasets hinders our interpretation of intercellular communication networks and regional gene expression patterns. New spatial (...)
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19:00Acute Treatment Effects on GFR in Randomized Clinical Trials of Kidney Disease Progression - J Am Soc NephrolBackground Acute changes in GFR can occur after initiation of interventions targeting progression of CKD. These acute changes complicate the interpretation of long-term treatment effects. Methods To assess the magnitude and consistency of acute effects in randomized clinical trials and (...)
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Background Gitelman syndrome is the most frequent hereditary salt-losing tubulopathy characterized by hypokalemic alkalosis and hypomagnesemia. Gitelman syndrome is caused by biallelic pathogenic variants in SLC12A3, encoding the Na+-Cl– cotransporter (NCC) expressed in the distal convoluted (...)
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19:00Xanthine Oxidoreductase Inhibitors Suppress the Onset of Exercise-Induced AKI in High HPRT Activity Urat1-Uox Double Knockout Mice - J Am Soc NephrolBackground Hereditary renal hypouricemia type 1 (RHUC1) is caused by URAT1/SLC22A12 dysfunction, resulting in urolithiasis and exercise-induced AKI (EIAKI). However, because there is no useful experimental RHUC1 animal model, the precise pathophysiologic mechanisms underlying EIAKI have yet to (...)
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19:00Kidney-Targeted Renalase Agonist Prevents Cisplatin-Induced Chronic Kidney Disease by Inhibiting Regulated Necrosis and Inflammation - J Am Soc NephrolBackground Repeated administration of cisplatin causes CKD. In previous studies, we reported that the kidney-secreted survival protein renalase (RNLS) and an agonist peptide protected mice from cisplatin-induced AKI. Methods To investigate whether kidney-targeted delivery of RNLS might (...)
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Background Receptor-interacting protein kinase 3 (RIPK3), a component of necroptosis pathways, may have an independent role in inflammation. It has been unclear which RIPK3-expressing cells are responsible for the anti-inflammatory effect of overall Ripk3 deficiency and whether Ripk3 (...)
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19:00Using Machine Learning to Identify Metabolomic Signatures of Pediatric Chronic Kidney Disease Etiology - J Am Soc NephrolBackground Untargeted plasma metabolomic profiling combined with machine learning (ML) may lead to discovery of metabolic profiles that inform our understanding of pediatric CKD causes. We sought to identify metabolomic signatures in pediatric CKD based on diagnosis: FSGS, obstructive uropathy (...)
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19:00The Trifecta Study: Comparing Plasma Levels of Donor-derived Cell-Free DNA with the Molecular Phenotype of Kidney Transplant Biopsies - J Am Soc NephrolBackground The relationship between the donor-derived cell-free DNA fraction (dd-cfDNA[%]) in plasma in kidney transplant recipients at time of indication biopsy and gene expression in the biopsied allograft has not been defined. Methods In the prospective, multicenter Trifecta study, we (...)
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19:00Mycophenolate Mofetil after Rituximab for Childhood-Onset Complicated Frequently-Relapsing or Steroid-Dependent Nephrotic Syndrome - J Am Soc NephrolBackground Rituximab is the standard therapy for childhood-onset complicated frequently relapsing or steroid-dependent nephrotic syndrome (FRNS/SDNS). However, most patients redevelop FRNS/SDNS after peripheral B cell recovery. Methods We conducted a multicenter, randomized, double-blind, (...)
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19:00Automated Segmentation of Kidney Cortex and Medulla in CT Images: A Multisite Evaluation Study - J Am Soc NephrolBackground In kidney transplantation, a contrast CT scan is obtained in the donor candidate to detect subclinical pathology in the kidney. Recent work from the Aging Kidney Anatomy study has characterized kidney, cortex, and medulla volumes using a manual image-processing tool. However, this (...)
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19:00Effect of a 3-Year Lifestyle Intervention in Patients with Chronic Kidney Disease: A Randomized Clinical Trial - J Am Soc NephrolBackground Supervised lifestyle interventions have the potential to significantly improve physical activity and fitness in patients with CKD. Methods To assess the efficacy of a lifestyle intervention in patients with CKD to improve cardiorespiratory fitness and exercise capacity over 36 (...)
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19:00Management of Adults with Newly Diagnosed Atrial Fibrillation with and without CKD - J Am Soc NephrolBackground Atrial fibrillation (AF) is highly prevalent in CKD and is associated with worse cardiovascular and kidney outcomes. Limited data exist on use of AF pharmacotherapies and AF-related procedures by CKD status. We examined a large "real-world" contemporary population with incident AF (...)
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