192 posts

8 March

J Hypertens http://journals.lww.com/jhypertension/

00:04
State of ambulatory hypertension education in U.S. internal medicine residency programs: a needs assessment survey - Gallagher, Benjamin D.; Windish, Donna M. J Hypertens

No abstract available -- CORRESPONDENCE
00:04
Analyzing various factors in the association between exercise and arterial stiffness in older Veterans - Gawash, Ahmed; Lo, David F. J Hypertens

No abstract available -- CORRESPONDENCE
00:04
Addressing diagnostic inertia following incidental adrenal mass discovery in patients with hypertension - Woods, Alison P.; Feeney, Timothy; Papageorge, Marianna V.; de Geus, Susanna W.L.; Tseng, Jennifer F.; Knapp, Philip E.; McAneny, David; Drake, F. Thurston J Hypertens

No abstract available -- CORRESPONDENCE

22 February

J Hypertens http://journals.lww.com/jhypertension/

07:00
Association between lifetime cannabis use and arterial stiffness in a middle-aged general population - Vallée, Alexandre J Hypertens

Background: No studies have investigated the association between arterial stiffness index (ASI) and cannabis use. The purpose of this study is to examine sex-stratified associations of cannabis use and ASI levels in a middle-aged general population. Methods: Cannabis use of 46 219 volunteers of (...) -- ORIGINAL ARTICLES

15 February

J Hypertens http://journals.lww.com/jhypertension/

07:00
Blood pressure variability: methodological aspects, clinical relevance and practical indications for management - a European Society of Hypertension position paper? - Parati, Gianfranco; Bilo, Grzegorz; Kollias, Anastasios; Pengo, Martino; Ochoa, Juan Eugenio; Castiglioni, Paolo; Stergiou, George S.; Mancia, Giuseppe; Asayama, Kei; Asmar, Roland; Avolio, Alberto; Caiani, Enrico G.; De La Sierra, Alejandro; Dolan, Eamon; Grillo, Andrea; Guzik, Przemys?aw; Hoshide, Satoshi; Head, Geoffrey A.; Imai, Yutaka; Juhanoja, Eeva; Kahan, Thomas; Kario, Kazuomi; Kotsis, Vasilios; Kreutz, Reinhold; Kyriakoulis, Konstantinos G.; Li, Yan; Manios, Efstathios; Mihailidou, Anastasia S.; Modesti, Pietro Amedeo; Omboni, Stefano; Palatini, Paolo; Persu, Alexandre; (...) J Hypertens

Blood pressure is not a static parameter, but rather undergoes continuous fluctuations over time, as a result of the interaction between environmental and behavioural factors on one side and intrinsic cardiovascular regulatory mechanisms on the other side. Increased blood pressure variability (...) -- CONSENSUS DOCUMENT

10 February

J Hypertens http://journals.lww.com/jhypertension/

07:00
Sleep irregularity and the association with hypertension and blood pressure levels: the ELSA-Brasil study - Parise, Barbara K.; Santos, Ronaldo B.; Mesas, Arthur E.; Silva, Wagner A.; Giatti, Soraya; Aielo, Aline N.; Cunha, Lorenna F.; Souza, Silvana P.; Bortolotto, Luiz A.; Griep, Rosane H.; Lotufo, Paulo A.; Bensenor, Isabela M.; Drager, Luciano F. J Hypertens

Objective: To evaluate the associations of sleep irregularity with hypertension (HTN) and blood pressure (BP) levels. Methods: Adult participants from the ELSA-Brasil performed a clinical evaluation including objective sleep duration (actigraphy), insomnia, and a sleep study for defining (...) -- ORIGINAL ARTICLES

8 February

J Hypertens http://journals.lww.com/jhypertension/

00:46
Evening or morning dosing of antihypertensive medications: valid epidemiological findings for consensus statement - Kawada, Tomoyuki J Hypertens

No abstract available -- CORRESPONDENCE
00:46
Reply to ‘Evening or morning dosing of antihypertensive medications: valid epidemiological findings for consensus statement’ - Stergiou, George; MacDonald, Thomas; Young, Robin; Kyriakoulis, Konstantinos G.; Kollias, Anastasios; Williams, Bryan; Tomaszewski, Maciej J Hypertens

No abstract available -- CORRESPONDENCE

1 February

J Hypertens http://journals.lww.com/jhypertension/

07:00
Sex-specific associations of reservoir–excess pressure parameters with age and subclinical vascular remodeling - Gimblet, Colin J.; Armstrong, Matthew K.; Nuckols, Virginia R.; DuBose, Lyndsey E.; Holwerda, Seth W.; Luehrs, Rachel E.; Lane, Abbi D.; Voss, Michelle W.; Pierce, Gary L. J Hypertens

Objective: Central artery reservoir pressure and excess pressure (XSP) are associated with cardiovascular disease (CVD) events and mortality. However, sex differences in the trajectory of central reservoir pressure and XSP with advancing age and their relations with vascular markers of (...) -- ORIGINAL ARTICLES
07:00
Relative prognostic importance of aortic and brachial blood pressures for cardiovascular and mortality outcomes in patients with resistant hypertension and diabetes: a two cohorts prospective study - Cardoso, Claudia R.L.; Leite, Nathalie C.; Salles, Gil F. J Hypertens

Objective: The prognostic importance of derived central/aortic blood pressures (BPs) in relation to brachial office and ambulatory BPs has never been investigated in patients with resistant hypertension (RHT) or type 2 diabetes (T2D). We aimed to evaluate it in two cohorts with 532 individuals (...) -- ORIGINAL ARTICLES

31 January

J Hypertens http://journals.lww.com/jhypertension/

07:00
The relationship between arginine vasopressin gene polymorphisms and plasma copeptin and hypertensive disorders of pregnancy: a nested case-control study - Sun, Yexiu; Guo, Ying; Xu, He; Zhao, Ji; Wu, Di; Hu, Jianwei; Wang, Dandan; Wu, Lei; Peng, Hao; Li, Hongmei J Hypertens

Objectives: This study aims to explore the relationship between polymorphism of the arginine vasopressin (AVP) gene and plasma copeptin concentration with the occurrence of hypertension in pregnancy. Methods: We conducted a matched nested case–control study in Chinese women. The genotypes of (...) -- ORIGINAL ARTICLES
07:00
Prevalence and clinical characteristics of renovascular hypertension associated with fibromuscular dysplasia in China - Kang, Yuan-Yuan; Chen, Yang; Wu, Qi-Hong; Dong, Hui; Zou, Yu-Bao; Gao, Ping-Jin; Xu, Jian-Zhong; Jiang, Xiong-Jing; Wang, Ji-Guang J Hypertens

Objectives: The aim of this study was to investigate the clinical characteristics of renal artery fibromuscular dysplasia (FMD) in patients in China and identify the cure rate of hypertension after angioplasty. Methods: Consecutive hypertensive patients with renal artery stenosis caused by FMD (...) -- ORIGINAL ARTICLES

30 January

J Hypertens http://journals.lww.com/jhypertension/

07:00
The effect of age, sex and BMI on the aldosterone-to-renin ratio in essential hypertensive individuals - Alnazer, Rawan M.; Veldhuizen, Gregory P.; de Leeuw, Peter W.; Kroon, Abraham A. J Hypertens

Objective: The aldosterone-to-renin ratio (ARR) is widely used as a screening test for primary aldosteronism, but its determinants in patients with essential hypertension are not fully known. The purpose of the present investigation is to identify the impact of age, sex and BMI on renin, (...) -- ORIGINAL ARTICLES
07:00
Stagnating rates of blood pressure control in Australia: insights from opportunistic screening of 10 046 participants of the May Measurement Month campaigns - Carnagarin, Revathy; Nolde, Janis M.; Yang, Jun; Marques, Francine Z.; Picone, Dean S.; Lambert, Gavin W.; Beaney, Thomas; Poulter, Neil R.; Schutte, Aletta E.; Reid, Christopher M.; Brockman, Derrin; Schlaich, Markus P. J Hypertens

Background: Raised blood pressure (BP) remains the single most important modifiable risk factor contributing to cardiovascular and all-cause mortality in Australia and worldwide. May Measurement Month, a global BP measurement and screening campaign initiated by the International Society of (...) -- ORIGINAL ARTICLES

25 January

J Hypertens http://journals.lww.com/jhypertension/

07:00
Transcription factor AP-2 gamma/Krüppel-like factor 10 axis is involved in miR-3656-related dysfunction of endothelial cells in hypertension - Ren, Yaxuan; Shi, Jikang; Liu, Sainan; Zhu, Wenfei; Shao, Aiyu; Qiao, Yichun; Li, Yong; Liu, Yunkai; Cheng, Yi; Liu, Yawen J Hypertens

Background: Dysfunction of endothelial cells links to microvascular rarefaction, reflecting the pathogenesis of hypertension. Our previous studies found that miR-3656 reduces nitric oxide generation and von Willebrand factor (vWF) cleavage, thereby retarding blood flow and potentially (...) -- ORIGINAL ARTICLES
07:00
Oscillometric pulse wave velocity estimated via the Mobil-O-Graph shows excellent accuracy in children, adolescents and young adults: an invasive validation study - Walser, Matthias; Schlichtiger, Jenny; Dalla-Pozza, Robert; Mandilaras, Guido; Tengler, Anja; Ulrich, Sarah; Oberhoffer, Felix Sebastian; Oberhoffer-Fritz, Renate; Böhm, Birgit; Haas, Nikolaus A.; Jakob, André J Hypertens

Aims: Increased arterial stiffness, measured as arterial pulse wave velocity (PWV) is associated with an elevated cardiovascular risk. Although noninvasive PWV measurement methods have been validated by invasive measurement, there is little such data on pediatric patients. The purpose of this (...) -- ORIGINAL ARTICLES

24 January

J Hypertens http://journals.lww.com/jhypertension/

07:00
Association between blood pressure and angiotensin-converting enzymes activity in prepubertal children? - Gaspar, Ana R.; Andrade, Beatriz; Mosca, Sara; Ferreira-Duarte, Mariana; Teixeira, Ana; Cosme, Dina; Albino-Teixeira, António; Ronchi, Fernanda A.; Leite, Ana P.; Casarini, Dulce E.; Areias, José C.; Sousa, Teresa; Afonso, Alberto C.; Morato, Manuela; Correia-Costa, Liane J Hypertens

Objectives: Angiotensin-converting enzymes’ (ACEs) relationship with blood pressure (BP) during childhood has not been clearly established. We aimed to compare ACE and ACE2 activities between BMI groups in a sample of prepubertal children, and to characterize the association between these (...) -- ORIGINAL ARTICLES

19 January

J Hypertens http://journals.lww.com/jhypertension/

07:00
Hyperkalemia by eplerenone or esaxerenone in the presence or absence of clarithromycin in hypertensive patients: a retrospective observational cohort study - Hirai, Toshinori; Ueda, Shun; Ogura, Toru; Katayama, Kan; Dohi, Kaoru; Hosohata, Keiko; Aoyama, Takahiko; Matsumoto, Yoshiaki; Iwamoto, Takuya J Hypertens

Objective: Mineralocorticoid receptor antagonists (MRAs), eplerenone and esaxerenone, cause hyperkalemia dose-dependently. We investigated the cytochrome P450 3A4-mediated drug?drug interaction between the MRAs and clarithromycin. Methods: This retrospective observational study included adult (...) -- ORIGINAL ARTICLES
07:00
Association between renal sympathetic denervation and arterial stiffness: the ASORAS study - Zeijen, Victor J.M.; Feyz, Lida; Kardys, Isabella; Geleijnse, Marcel L.; Van Mieghem, Nicolas M.; Zijlstra, Felix; Lafeber, Melvin; Van Der Geest, Rob J.; Hirsch, Alexander; Daemen, Joost J Hypertens

Objectives: Renal sympathetic denervation (RDN) reduces blood pressure (BP). However, one out of three patients does not exhibit a significant BP response to the therapy. This study investigates the association between noninvasive vascular stiffness indices and RDN-mediated BP reduction. (...) -- ORIGINAL ARTICLES
07:00
Benefit of treatment based on indapamide mostly combined with perindopril on mortality and cardiovascular outcomes: a pooled analysis of four trials - Chalmers, John; Mourad, Jean-Jacques; Brzozowska-Villatte, Romualda; De Champvallins, Martine; Mancia, Giuseppe J Hypertens

Objective: The aim of this study was to assess the reduction in all-cause death and cardiovascular outcomes associated with the administration of the thiazide-like diuretic indapamide monotherapy or in combination with perindopril as a blood pressure lowering drug in randomized controlled (...) -- ORIGINAL ARTICLES

17 January

J Hypertens http://journals.lww.com/jhypertension/

07:00
Biomechanics models predict increasing smooth muscle tone as a novel therapeutic target for central arterial dysfunction in hypertension - Pewowaruk, Ryan J.; Colebank, Mitchel J.; Spronck, Bart; Korcarz, Claudia E.; Gepner, Adam D. J Hypertens

Introduction: Vasodilation can paradoxically increase arterial stiffness in older, hypertensive adults. This study modeled increasing smooth muscle tone as a therapeutic strategy to improve central arterial dysfunction in hypertension using participant-specific simulations. Methods: (...) -- ORIGINAL ARTICLES
07:00
Circ_0001326 suppresses trophoblast cell proliferation, invasion, migration and epithelial–mesenchymal transition progression in preeclampsia by miR-188-3p/HtrA serine peptidase 1 axis - Gao, Xue; Qu, Haina; Zhang, Yue J Hypertens

Background: It has been reported that the alteration of circular RNAs (circRNAs) during preeclampsia (PE) can be associated with the pathogenesis of this disease. Herein, this work investigated the potential functions and mechanism of circ_0001326 in PE process. Methods: The levels of genes and (...) -- ORIGINAL ARTICLES

12 January

J Hypertens http://journals.lww.com/jhypertension/

07:00
Effects of blood pressure unawareness and poor adherence to antihypertensive drugs on outcomes of cerebrovascular accidents among patients with their first-ever stroke - Bawand, Rashed; Ghiasian, Masoud; Khazaei, Mojtaba; Samadyan, Mustapha; Moradi, Abbas J Hypertens

Aims: Our main target was to investigate the relationship of blood pressure (BP) unawareness and poor antihypertensive drug adherence with the clinical outcomes of the stroke including hospitalization time, degree of disability, and mortality rate. Methods and results: In this cross-sectional (...) -- ORIGINAL ARTICLES
07:00
Combined effects of blood pressure and glycemic status on risk of heart failure: a population-based study - Kobayashi, Ayako; Fujihara, Kazuya; Yamada, Mayuko Harada; Sato, Takaaki; Yaguchi, Yuta; Kitazawa, Masaru; Matsubayashi, Yasuhiro; Iwanaga, Midori; Yamada, Takaho; Kodama, Satoru; Sone, Hirohito J Hypertens

Aims: To investigate the combined effects of blood pressure (BP) and glycemic status on the risk of heart failure. Methods: Examined was a Japanese claims database from 2008 to 2019 on 589 621 individuals. Cox proportional hazards model identified the incidence of heart failure among five (...) -- ORIGINAL ARTICLES
07:00
Methods of arterial stiffness calculation and cardiovascular disease events: the multiethnic study of atherosclerosis - Pewowaruk, Ryan J.; Korcarz, Claudia; Stein, James H.; Bluemke, David; Tedla, Yacob; Gepner, Adam D. J Hypertens

Background: A wide variety of different formulae have been used to calculate local arterial stiffness with little external validation in relationship to cardiovascular events. We compared the associations of several arterial stiffness calculations in a large, multiethnic cohort. Methods: The (...) -- ORIGINAL ARTICLES
07:00
CircRNA_06354 might promote early-onset preeclampsia in humans via hsa-miR-92a-3p/vascular endothelial growth factor-A - Zhang, Yueming; Zhao, Yuanyuan; Yu, Fangfang; Li, Xiang; Chen, Xionghui; Zhu, Dan; Sun, Jie; Huang, Qin; Li, Min; Sun, Miao; Zhang, Pengjie J Hypertens

Background: Early-onset preeclampsia (EOPE) is a serious pregnancy disorder with multisystem complications. Recently, circRNA was reported to participate in the progression of EOPE. However, the role and mechanism of circRNA_06354 in the pathophysiological development of EOPE remain unclear. (...) -- ORIGINAL ARTICLES
07:00
How acute renal failure led to the diagnosis of aortic coarctation - Kantauskaite, Marta; Fürst, Günter; Minko, Peter; Antoch, Gerald; Rump, Lars Christian; Potthoff, Sebastian Alexander J Hypertens

The present case report focuses on a rare presentation of aortic coarctation. A 38-year-old man with well-controlled arterial hypertension, minimal change glomerulonephritis and colitis ulcerosa was suffering from recurrent acute renal failure episodes during viral gastroenteritis. No other (...) -- CASE REPORTS

9 January

J Hypertens http://journals.lww.com/jhypertension/

07:00
Revisiting malignant hypertension: rationale and design of the ‘HAMA cohort’, on behalf of the ESH working group ‘hypertension and the kidney’ - Boulestreau, Romain; Lorthioir, Aurélien; Persu, Alexandre; Sarafidis, Pantelis; Cremer, Antoine; Tharaux, Pierre-Louis; Rubin, Sebastien; Maier, Benjamin; Mazighi, Mikael; Paques, Michel; Bonnin, Sophie; Dreau, Herve; Debeugny, Stéphane; Halimi, Jean Michel; Gosse, Philippe J Hypertens

Background: Malignant hypertension has not disappeared and is associated with a poor prognosis. Yet, so far, it has received limited attention from the medical community. Guidelines are mainly based on expert consensus and low quality evidences. Method: We set up a prospective, multicenter, (...) -- ORIGINAL ARTICLES

3 January

J Hypertens http://journals.lww.com/jhypertension/

07:00
Training, detraining and retraining effects of moderate vs. high intensity exercise training programme on cardiovascular risk factors - Ávila-Gandía, Vicente; Ramos-Campo, Domingo Jesús; García-Sánchez, Esther; Luque-Rubia, Antonio Jesús; López, Asensio; López-Román, Francisco Javier J Hypertens

Background: The aim of the present study was to analyse the effect of 12 weeks of training, 7 weeks of detraining and 16 weeks of retraining using a moderate or high intensity training programme on cardiovascular risk factors in hypertensive patients. Method: Thirty-four patients took part in (...) -- ORIGINAL ARTICLES
07:00
Association between lung function and hypertension and home hypertension in a Japanese population: the Tohoku Medical Megabank Community-Based Cohort Study - Takase, Masato; Yamada, Mitsuhiro; Nakamura, Tomohiro; Nakaya, Naoki; Kogure, Mana; Hatanaka, Rieko; Nakaya, Kumi; Chiba, Ippei; Kanno, Ikumi; Nochioka, Kotaro; Tsuchiya, Naho; Hirata, Takumi; Hamanaka, Yohei; Sugawara, Junichi; Kobayashi, Tomoko; Fuse, Nobuo; Uruno, Akira; Kodama, Eiichi N.; Kuriyama, Shinichi; Tsuji, Ichiro; Hozawa, Atsushi J Hypertens

Background: Although several studies have shown an inverse association between lung function and hypertension, few studies have examined the association between lung function and hypertension among never-smokers, and no study has investigated the association between lung function and home (...) -- ORIGINAL ARTICLES
07:00
Unilateral renal atrophy 4 years after renal sympathetic denervation: a case report - Zeijen, Victor J.M.; Hirsch, Alexander; Betjes, Michiel G.H.; Daemen, Joost J Hypertens

Renal sympathetic denervation (RDN) carries a low risk of renal artery stenosis, and most cases occur within the first year. However, limited data are available on long-term incidence. Here, we present a case of a 68-year-old woman who underwent radiofrequency RDN for resistant hypertension. (...) -- CASE REPORTS
19:14
Cardiovascular disease risk in patients with type 2 diabetes and hypertension - Kawada, Tomoyuki J Hypertens

No abstract available -- CORRESPONDENCE
19:14
ESH Summer School 2022: great experience for participants and an important achievement for ESH organization - Brguljan-Hitij, Jana; McNally, Ryan; Šinigoj, Petra; Hornstrup, Bodil Gade; Oppelaar, Marjet; Lovic, Dragan J Hypertens

No abstract available -- CORRESPONDENCE
19:14
Intravenous antihypertensive drugs: a double-edged sword? - van Twist, Daan J.L.; Kietselaer, Bas L.J.H. J Hypertens

No abstract available -- EDITORIAL
19:14
Urine excretion of C3dg and sC5b-9 coincide with proteinuria and development of preeclampsia in pregnant women with type-1 diabetes - Isaksson, Gustaf L.; Nielsen, Lise H.; Palarasah, Yaseelan; Jensen, Dorte M.; Andersen, Lise L. T.; Madsen, Kirsten; Bistrup, Claus; Jørgensen, Jan S.; Ovesen, Per G.; Jensen, Boye L. J Hypertens

Objective: Pregnant women with type-1 diabetes have an increased risk of preeclampsia with kidney injury and cardiovascular complications. Urine excretion of plasmin and soluble membrane attack complex (sC5b-9) is elevated in severe preeclampsia. We hypothesized a coupling between these events (...) -- ORIGINAL ARTICLES
19:14
Adrenomedullin in paraventricular nucleus attenuates adipose afferent reflex and sympathoexcitation via receptors mediated nitric oxide–gamma-aminobutyric acid A type receptor pathway in rats with obesity-related hypertension - Wang, Fang-Zheng; Qian, Pei; Liu, Mu-Yue; Ding, Lei; Wang, Hong-Yu; Wang, Qian; Ding, Zi-Yang; Jin, Fei-Yu; Li, Rui-Gang; Zhou, Ye-Bo J Hypertens

Background: Hypothalamic paraventricular nucleus (PVN) is an important central site for the control of the adipose afferent reflex (AAR) that increases sympathetic outflow and blood pressure in obesity-related hypertension (OH). Method: In this study, we investigated the effects of nitric oxide (...) -- ORIGINAL ARTICLES

27 December

J Hypertens http://journals.lww.com/jhypertension/

07:00
Adolescent blood pressure classification curves and cardiometabolic risk factors: a comparison of the Brazilian and American references - Medeiros, Brenda M.; Da Silva, Thiago L.N.; Bloch, Katia V.; Kuschnir, Maria C.C.; Sbaraini, Mariana; Schaan, Beatriz D.; Cureau, Felipe V. J Hypertens

Background: The American Academy of Pediatrics (AAP) adolescent blood pressure (BP) percentiles were updated in 2017, and have been used as reference in Brazil since then. However, specific BP percentiles for Brazilian adolescents were recently proposed based on data from the Study of (...) -- ORIGINAL ARTICLES
07:00
Trends in stroke, cardiovascular disease, and medical expenditure under a community-based long-term stroke prevention program - Yamagishi, Kazumasa; Sankai, Tomoko; Muraki, Isao; Umesawa, Mitsumasa; Cui, Renzhe; Imano, Hironori; Kihara, Tomomi; Noda, Hiroyuki; Ikeda, Ai; Ohira, Tetsuya; Tanigawa, Takeshi; Kitamura, Akihiko; Sato, Shinichi; Kiyama, Masahiko; Iso, Hiroyasu J Hypertens

Background: Evidence on the effects of preventive measures for noncommunicable disease is urgently needed for low-income and middle-income countries suffering from stroke epidemics along with population aging. Objectives: We sought to examine the impact of a community-based stroke prevention (...) -- ORIGINAL ARTICLES
07:00
One-month changes in blood pressure-adjusted pulse wave velocity for predicting long-term cardiovascular outcomes in patients undergoing percutaneous coronary intervention - Kim, Hack-Lyoung; Joh, Hyun Sung; Lim, Woo-Hyun; Seo, Jae-Bin; Kim, Sang-Hyun; Zo, Joo-Hee; Kim, Myung-A J Hypertens

Objective: The prognostic value of changes in arterial stiffness has not been well evaluated. This study was conducted to investigate whether the change in arterial stiffness one month after percutaneous coronary intervention (PCI) affects the long-term cardiovascular prognosis. Methods: A (...) -- ORIGINAL ARTICLES

24 December

J Hypertens http://journals.lww.com/jhypertension/

12:39
Geriatricians’ perspective on findings from the STEP and the SPRINT trials with a special focus on their similarities and differences - Bahat, Gulistan; Ozkok, Serdar; Petrovic, Mirko; Benetos, Athanese J Hypertens

No abstract available -- CORRESPONDENCE
12:39
Dynamic of bedside ultrasound venous and pulmonary congestion assessment in patients with arterial hypertension and decompensated heart failure: Erratum J Hypertens

No abstract available -- ERRATA
12:39
Patient profiling in acute decompensated heart failure: Erratum J Hypertens

No abstract available -- ERRATA

22 December

J Hypertens http://journals.lww.com/jhypertension/

07:00
Challenges in the evaluation of endothelial cell dysfunction: a statement from the European Society of Hypertension Working Group on Endothelin and Endothelial Factors - Rossi, Gian Paolo; Barton, Matthias; Dhaun, Neeraj; Rizzoni, Damiano; Seccia, Teresa M. J Hypertens

Endothelial cell function is mediated by different mechanisms in different vascular beds. Moreover, in humans, endothelial cell dysfunction triggers and accelerates the progression of cardiovascular and chronic kidney diseases. Progression of such diseases can be in part mitigated by the (...) -- CONSENSUS DOCUMENT
07:00
Orthostatic hypotension, falls and in-hospital mortality among elderly patients with and without type 2 diabetes - Beretta, Mileni V.; Milan, Victoria B.; Hoffmeister, Mariana C.; Rodrigues, Ticiana C. J Hypertens

Objectives: To evaluate the association of falls and in-hospital mortality with the presence of orthostatic hypotension and type 2 diabetes mellitus (T2D). The study also aims to identify whether the orthostatic hypotension assessed at 1 min or at 3 min can predict falls and mortality, as a (...) -- ORIGINAL ARTICLES
07:00
Saturated fatty acid promotes calcification via suppressing SIRT6 expression in vascular smooth muscle cells - Tao, Yafen; Wu, Yue; Jiang, Chuanyue; Wang, Qianghua; Geng, Xu; Chen, Lei; Zhou, Sihui; Wang, Xuegu; Han, Mingliang; Du, Danli; Ding, Biao; Li, Xiang J Hypertens

Background: This study aims to investigate the effects of saturated free fatty acid on calcification and SIRT6 expression in vascular smooth muscle cells (VSMCs) and the role of SIRT6 in regulating VSMC calcification. Methods: Sprague–Dawley rats were randomly allocated to two groups: rats with (...) -- ORIGINAL ARTICLES
07:00
Associations of childhood adiposity with adult intima–media thickness and inflammation: a 20-year longitudinal population-based cohort - Fujikawa, Tomona; Kobayashi, Masatake; Wagner, Sandra; Duarte, Kevin; Scherdel, Pauline; Heude, Barbara; Dupont, Vincent; Bozec, Erwan; Bresso, Emmanuel; Zannad, Faiez; Rossignol, Patrick; Girerd, Nicolas J Hypertens

Background: The associations between childhood adiposity and adult increased carotid intima–media thickness (cIMT) have been well established, which might be corroborated by the association between adiposity in children and inflammation in adults. However, longitudinal data regarding biological (...) -- ORIGINAL ARTICLES
07:00
Unmasking left ventricular systolic dysfunction in masked hypertension: looking at myocardial strain. A review and meta-analysis - Cuspidi, Cesare; Gherbesi, Elisa; Faggiano, Andrea; Sala, Carla; Grassi, Guido; Tadic, Marijana J Hypertens

Background and Aim: A growing body of evidence supports the view that masked hypertension (MH) (i.e. normal office and elevated out-of-office BP) is a blood pressure (BP) phenotype associated with increased risk of subclinical organ damage, cardiovascular disease and death as compared to true (...) -- ORIGINAL ARTICLES
07:00
Concomitantly higher resting arterial blood pressure and transduction of sympathetic neural activity in human obesity without hypertension - Holwerda, Seth W.; Gangwish, Megan E.; Luehrs, Rachel E.; Nuckols, Virginia R.; Thyfault, John P.; Miles, John M.; Pierce, Gary L. J Hypertens

Objective: Central (abdominal) obesity is associated with elevated adrenergic activity and arterial blood pressure (BP). Therefore, we tested the hypothesis that transduction of spontaneous muscle sympathetic nerve activity (MSNA) to BP, that is, sympathetic transduction, is augmented in (...) -- ORIGINAL ARTICLES

16 December

J Hypertens http://journals.lww.com/jhypertension/

07:00
Health football beats them all: subgroup analysis of the 3F (Fit&Fun with Football) study on white-coat hypertension, sustained hypertension, dippers, nondippers, and on pharmacologically un(treated) arterial hypertension - Schrader, Bastian; Conradi, Charis; Lüders, Stephan; Vaske, Bernhardt; Koziolek, Martin; Gehlenborg, Eugen; Haller, Hermann; Elsässer, Albrecht; Schrader, Joachim J Hypertens

Background: The 3F study (Fit&Fun with Football) demonstrated a significant reduction in blood pressure, antihypertensive medication, body weight, stress and depression through health football. Health football could be a popular tool to unleash the full preventive potential of physical (...) -- ORIGINAL ARTICLES
07:00
Associations of polygenic risk scores for preeclampsia and blood pressure with hypertensive disorders of pregnancy - Nurkkala, Jouko; Kauko, Anni; FinnGen, ; Laivuori, Hannele; Saarela, Tanja; Tyrmi, Jaakko S.; Vaura, Felix; Cheng, Susan; Bello, Natalie A.; Aittokallio, Jenni; Niiranen, Teemu J Hypertens

Background: Preexisting hypertension increases risk for preeclampsia. We examined whether a generic blood pressure polygenic risk score (BP-PRS), compared with a preeclampsia-specific polygenic risk score (PE-PRS), could better predict hypertensive disorders of pregnancy. Methods: Our study (...) -- ORIGINAL ARTICLES

14 December

J Hypertens http://journals.lww.com/jhypertension/

07:00
A novel professional automated auscultatory blood pressure monitor with visual display of Korotkoff sounds: InBody BPBIO480KV validation according to the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization Universal Standard - Ntineri, Angeliki; Theodosiadi, Aikaterini; Menti, Ariadni; Kyriakoulis, Konstantinos G.; Ntousopoulos, Vasileios; Kollias, Anastasios; Stergiou, George S. J Hypertens

Objective: A novel automated auscultatory upper arm-cuff blood pressure (BP) monitor (InBody BPBIO480KV) for office use was developed. An electronic stethoscope embedded in the device cuff records the Korotkoff sounds, which are audible to the user and graphically displayed during cuff (...) -- ORIGINAL ARTICLES

13 December

J Hypertens http://journals.lww.com/jhypertension/

07:00
Postpartum medical management of hypertension and risk of readmission for hypertensive complications - Lovgren, Todd; Connealy, Brendan; Yao, Ruofan; D. Dahlke, Joshua J Hypertens

Objective: To compare the risk of readmission in those receiving no treatment, labetalol, nifedipine or both at hospital discharge following delivery complicated by presence of hypertension. Study design: Retrospective study at a single tertiary care center over a 4-year period (2017–2020). (...) -- ORIGINAL ARTICLES

8 December

J Hypertens http://journals.lww.com/jhypertension/

07:00
Effect of finerenone on ambulatory blood pressure in chronic kidney disease in type 2 diabetes - Agarwal, Rajiv; Ruilope, Luis M.; Ruiz-Hurtado, Gema; Haller, Hermann; Schmieder, Roland E.; Anker, Stefan D.; Filippatos, Gerasimos; Pitt, Bertram; Rossing, Peter; Lambelet, Marc; Nowack, Christina; Kolkhof, Peter; Joseph, Amer; Bakris, George L J Hypertens

Objective: Finerenone is a selective nonsteroidal mineralocorticoid receptor antagonist with a short half-life. Its effects on cardiorenal outcomes were thought to be mediated primarily via nonhemodynamic pathways, but office blood pressure (BP) measurements were insufficient to fully assess (...) -- ORIGINAL ARTICLES
07:00
Exercise increases arterial stiffness independent of blood pressure in older Veterans - Pewowaruk, Ryan J.; Hein, Amy J.; Hansen, Kristin M.; Barnes, Jill N.; Chesler, Naomi C.; Korcarz, Claudia E.; Gepner, Adam D. J Hypertens

Background: Exercise-induced changes in arterial function could contribute to a hypertensive response to exercise (HRE) in older individuals. We performed the present analysis to define the acute arterial stiffness response to exercise in ambulatory older adults. Methods: Thirty-nine Veterans (...) -- ORIGINAL ARTICLES

2 December

J Hypertens http://journals.lww.com/jhypertension/

07:00
A meta-analysis of the haemodynamics of primary hypertension in children and adults - Li, Ye; Haseler, Emily; McNally, Ryan; Sinha, Manish D.; Chowienczyk, Phil J. J Hypertens

We performed a systematic review and meta-analysis to determine the relative contributions of elevated cardiac output and systemic vascular resistance to hypertension in children and adults. This included 27 studies on 11 765 hypertensive and normotensive children and adults in whom cardiac (...) -- REVIEWS

28 November

J Hypertens http://journals.lww.com/jhypertension/

07:00
Age-related patterns of ambulatory blood pressure in a large cohort of individuals referred to Italian community pharmacies: results from the templar project - Omboni, Stefano; Ballatore, Tommaso; Rizzi, Franco; Tomassini, Fernanda; Campolo, Luca; Panzeri, Edoardo J Hypertens

Objectives: Ambulatory blood pressure monitoring (ABPM) provides extensive information on several BP parameters other than the average BP during daily life. Through this analysis of the TEMPLAR study, we sought to understand better the features of age-related changes in ABP patterns and (...) -- ORIGINAL ARTICLES

25 November

J Hypertens http://journals.lww.com/jhypertension/

07:00
Time of blood pressure in target range in acute ischemic stroke - Kakaletsis, Nikolaos; Ntaios, George; Milionis, Haralampos; Protogerou, Athanasios D.; Karagiannaki, Anastasia; Chouvarda, Ioanna; Dourliou, Vasiliki; Ladakis, Ioannis; Kaiafa, Georgia; Daios, Stylianos; Doumas, Michael; Savopoulos, Christos J Hypertens

Objective: The purpose of this study was to investigate the association of blood pressure (BP) time-in-target range (TTR) derived from 24-h ambulatory BP monitoring (ABPM) during the acute phase of ischemic stroke (AIS), with the severity of stroke and its predictive value for the 3 months (...) -- ORIGINAL ARTICLES
07:00
Sleep fragmentation during rapid eye movement sleep and hypertension in obstructive sleep apnea - Ren, Rong; Zhang, Ye; Yang, Linghui; Shi, Yuan; Covassin, Naima; Tang, Xiangdong J Hypertens

Objective: Sleep fragmentation determined by repetitive arousals from sleep in obstructive sleep apnea (OSA) is associated with hypertension. We aimed to quantify the independent association of arousals during rapid eye movement (REM)/non-rapid eye movement (NREM) sleep with prevalent (...) -- ORIGINAL ARTICLES

18 November

J Hypertens http://journals.lww.com/jhypertension/

07:00
Hypotensive unawareness in Parkinson's disease-related autonomic dysfunction - Slavescu, Andreea; Byrne, Lisa; Lavan, Amanda; Briggs, Robert J Hypertens

This case demonstrates how orthostatic hypotension in the absence of typical symptoms of light-headedness/dizziness when changing posture, can contribute to the burden of falls in Parkinson's disease. At least one-third of people with severe orthostatic hypotension do not report typical (...) -- CASE REPORT
07:00
PERson-centredness in Hypertension management using Information Technology: a randomized controlled trial in primary care - Andersson, Ulrika; Nilsson, Peter M.; Kjellgren, Karin; Hoffmann, Mikael; Wennersten, André; Midlöv, Patrik J Hypertens

Objectives: To increase the proportion of individuals with hypertension obtaining a blood pressure (BP) of less than 140/90 mmHg by improving the management of hypertension in daily life from a person-centred perspective. Methods: In this unblinded randomized controlled trial, we tested an (...) -- ORIGINAL ARTICLES
07:00
Antihypertensive medication classes and the risk of dementia over a decade of follow-up - Schroevers, Jakob L.; Eggink, Esmé; Hoevenaar-Blom, Marieke P.; Van Dalen, Jan Willem; Van Middelaar, Tessa; Van Gool, Willem A.; Richard, Edo; Moll Van Charante, Eric P. J Hypertens

Introduction: Use of angiotensin II (ATII)-stimulating antihypertensive medication (AHM), including angiotensin receptor blockers (ARBs) and dihydropyridine calcium channel blockers (CCBs), has been associated with lower dementia risk. Previous studies had relatively short follow-up periods. (...) -- ORIGINAL ARTICLES
07:00
Estimating population level 24-h sodium excretion using spot urine samples in older adults in rural South Africa - Du Toit, Jacques D.; Kapaon, David; Crowther, Nigel J.; Abrahams-Gessel, Shafika; Fabian, June; Kabudula, Chodziwadziwa W.; Wade, Alisha N.; Tollman, Stephen; Gaziano, Thomas A. J Hypertens

Background: South Africa has introduced regulations to reduce sodium in processed foods. Assessing salt consumption with 24-h urine collection is logistically challenging and expensive. We assess the accuracy of using spot urine samples to estimate 24-h urine sodium (24hrUNa) excretion at the (...) -- ORIGINAL ARTICLES
07:00
Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage - Ghazi, Lama; Li, Fan; Simonov, Michael; Yamamoto, Yu; Nugent, James T.; Greenberg, Jason H.; Bakhoum, Christine Y.; Peixoto, Aldo J.; Wilson, F. Perry J Hypertens

Background: Treatment of severe inpatient hypertension (HTN) that develops during hospitalization is not informed by guidelines. Intravenous (i.v.) antihypertensives are used to manage severe HTN even in the absence of acute target organ damage; however they may result in unpredictable blood (...) -- ORIGINAL ARTICLES
07:00
Effects of minimally and ultra-processed foods on blood pressure in Brazilian adults: a two-year follow up of the CUME Project - Rezende-Alves, Katiusse; Hermsdorff, Helen Hermana Miranda; Miranda, Aline Elizabeth da Silva; Bressan, Josefina; Mendonça, Raquel de Deus; de Oliveira, Fernando Luiz Pereira; Pimenta, Adriano Marçal J Hypertens

Aim: To assess the association of food consumption according to degree of processing with changes in systolic (SBP) and diastolic (DBP) blood pressure in adult participants of a Brazilian cohort. Methods: Longitudinal study with 2496 adult participants of the Cohort of Universities of Minas (...) -- ORIGINAL ARTICLES

17 November

J Hypertens http://journals.lww.com/jhypertension/

07:00
Cardiovagal baroreflex sensitivity, blood pressure and blood pressure variability – the Maastricht study - Zhou, Tan Lai; Reulen, Jos P.H.; Van Der Staaij, Hilde; Stehouwer, Coen D.A.; Van Greevenbroek, Marleen; Henry, Ronald M.A.; Kroon, Abraham A. J Hypertens

Objective: Low baroreflex sensitivity (BRS) has been hypothesized to underlie high blood pressure (BP) and greater BP variability on the longer term, but evidence is scarce. In addition, these associations may differ by sex and (pre)diabetes. Therefore, we investigated whether cardiovagal BRS (...) -- ORIGINAL ARTICLES

16 November

J Hypertens http://journals.lww.com/jhypertension/

07:00
Isolated systolic or diastolic hypertension and mortality risk in young adults using the 2017 American College of Cardiology/American Heart Association blood pressure guideline: a longitudinal cohort study - Bo, Yacong; Yu, Tsung; Guo, Cui; Chang, Ly-yun; Huang, Junjie; Wong, Martin C.S.; Tam, Tony; Lao, Xiang Qian J Hypertens

Background: Little is known regarding the health effects of different hypertension phenotypes including isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and systolic and diastolic hypertension (SDH) defined by the 2017 American College of Cardiology (ACC)/American (...) -- ORIGINAL ARTICLES

9 November

J Hypertens http://journals.lww.com/jhypertension/

07:00
Ulinastatin ameliorates preeclampsia induced by N(gamma)-nitro-l-arginine methyl ester in a rat model via inhibition of the systemic and placental inflammatory response - Yu, Zhiqiang; Liu, Yan; Zhang, Yan; Cui, Jian; Dong, Yan; Zhang, Li; Liu, Peng; Hao, Yingxin; Xu, Yanning; Wang, Jianbo J Hypertens

Background: The pathogenesis of preeclampsia (PE) is associated with inflammation and endothelial damage. Ulinastatin (UTI) mainly inhibits proteolytic activity and significantly reduces the release of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-?) from macrophages. It also (...) -- ORIGINAL ARTICLES

7 November

J Hypertens http://journals.lww.com/jhypertension/

07:00
Association of sodium intake with adverse left atrial function and left atrioventricular coupling in Chinese - Yin, Lili; Mei, Jiajie; Dong, Jianli; Qu, Xiaofeng; Jiang, Yinong J Hypertens

Objectives: High sodium intake is strongly associated with hypertension and obesity. This study aims to investigate the relationship between 24-h urinary sodium (a surrogate measure of sodium intake), ambulatory blood pressure parameters, left atrial function, and left atrioventricular (...) -- ORIGINAL ARTICLES

2 November

J Hypertens http://journals.lww.com/jhypertension/

06:00
Hypertension in Turner syndrome: a review of proposed mechanisms, management and new directions - Jones, Lily; Blair, Joanne; Hawcutt, Daniel B.; Lip, Gregory Y.H.; Shantsila, Alena J Hypertens

Acquired cardiovascular diseases account for much of the increased risk of premature death in patients with Turner syndrome (TS). Hypertension is a major modifiable cardiovascular risk factor. It has a high prevalence in TS developing at an early age and thus leading to prolonged exposure to (...) -- REVIEWS
06:00
Systolic and diastolic left ventricular function in children with primary hypertension: a systematic review and meta-analysis - Rus, Rina R.; Pac, Micha?; Obrycki, ?ukasz; Sa?sak, Elif; Azukaitis, Karolis; Sinha, Manish D.; Jankauskiene, Augustina; Litwin, Mieczys?aw J Hypertens

Objective: Evaluation of left ventricular function provides early evidence of target-organ damage in children with primary hypertension. We performed a systematic review and meta-analysis of left ventricular systolic and diastolic function in children and adolescents with primary hypertension. (...) -- ORIGINAL ARTICLES
06:00
Accelerated vascular age in adolescents with primary hypertension - Obrycki, ?ukasz; Sarnecki, J?drzej; Pac, Micha?; Derezi?ski, Tadeusz; Lewandowska, Weronika; Feber, Janusz; Litwin, Mieczys?aw J Hypertens

Background: Primary hypertension may lead to early vascular ageing. We aimed to evaluate differences between expected vascular age based on pulse wave velocity (PWV)/carotid intima-media thickness (cIMT) and actual chronological age (CHA) in adolescents with primary hypertension. Methods: Three (...) -- ORIGINAL ARTICLES
06:00
Serum uric acid / serum creatinine ratio as a predictor of cardiovascular events. Detection of prognostic cardiovascular cut-off values - Casiglia, Edoardo; Tikhonoff, Valérie; Virdis, Agostino; Grassi, Guido; Angeli, Fabio; Barbagallo, Carlo M.; Bombelli, Michele; Cicero, Arrigo F.G.; Cirillo, Massimo; Cirillo, Pietro; Dell’Oro, Raffaella; D’elia, Lanfranco; Desideri, Giovambattista; Ferri, Claudio; Galletti, Ferruccio; Gesualdo, Loreto; Giannattasio, Cristina; Iaccarino, Guido; Lippa, Luciano; Mallamaci, Francesca; Masi, Stefano; Maloberti, Alessandro; Masulli, Maria; Mazza, Alberto; Mengozzi, Alessandro; Muiesan, Maria Lorenza; Nazzaro, Pietro; Palatini, Paolo; Parati, Gianfranco; Pontremoli, Roberto; Quarti-Trevano, Fosca; (...) J Hypertens

Objective: In the frame of the Uric Acid Right for Heart Health (URRAH) study, a nationwide multicenter study involving adult participants recruited on a regional community basis from all the territory of Italy under the patronage of the Working Group on Uric Acid and Cardiovascular Risk of the (...) -- ORIGINAL ARTICLES
06:00
The use of loop diuretics in the context of hypertensive disorders of pregnancy: a systematic review and meta-analysis - Malhamé, Isabelle; Dong, Susan; Syeda, Ambreen; Ashraf, Rizwana; Zipursky, Jonathan; Horn, Daphne; Daskalopoulou, Stella S.; D'Souza, Rohan J Hypertens

Aims: Addressing volume expansion may improve the management of hypertension across the pregnancy continuum. We conducted a systematic review to summarize the evidence on the use of loop diuretics in the context of hypertensive disorders during pregnancy and the postpartum period. Methods and (...) -- REVIEWS

27 October

J Hypertens http://journals.lww.com/jhypertension/

07:00
Changes in ambulatory blood pressure during the transition to retirement - Karelius, Saana; Vahtera, Jussi; Suorsa, Kristin; Heinonen, Olli J.; Pentti, Jaana; Niiranen, Teemu J.; Stenholm, Sari J Hypertens

Objectives: Retirement is a major life event characterized by removal of work-related stressors and changes in health behaviours. The association between retirement and changes in blood pressure (BP), and particularly in ambulatory BP, has been scarcely studied. We aimed to examine changes in (...) -- ORIGINAL ARTICLES

20 October

J Hypertens http://journals.lww.com/jhypertension/

07:00
Systolic blood pressure at age 40 and cognitive function 25 years later: the Akershus Cardiac Examination (ACE) 1950 Study - Walle-Hansen, Marte M.; Berge, Trygve; Vigen, Thea; Myrstad, Marius; Hagberg, Guri; Ihle-Hansen, Hege; Sandset, Else C.; Thommessen, Bente; Ariansen, Inger K.H.; Lyngbakken, Magnus N.; Røsjø, Helge; Rønning, Ole M.; Tveit, Arnljot; Ihle-Hansen, Håkon J Hypertens

Objectives: Hypertension in midlife is a risk factor for cognitive impairment. Still, the ideal midlife blood pressure (BP) remains unknown. We examined associations between different systolic blood pressure (SBP) levels at the age of 40–43 years and change in SBP over a 25-year period with (...) -- ORIGINAL ARTICLES
07:00
Impact of oscillometric measurement artefacts in ambulatory blood pressure monitoring on estimates of average blood pressure and of its variability: a pilot study - Bothe, Tomas L.; Bilo, Grzegorz; Parati, Gianfranco; Haberl, Ralph; Pilz, Niklas; Patzak, Andreas J Hypertens

Objective: Ambulatory blood pressure monitoring (ABPM) plays an important role in the diagnosis of hypertension. However, methodological factors and the measurement conditions affect the results and may lead to incorrect classification of the patient. We performed a pilot study to evaluate the (...) -- ORIGINAL ARTICLES

14 October

J Hypertens http://journals.lww.com/jhypertension/

07:00
Symptom experiences in hypertension: a mixed methods systematic review - Horne, Carolyn E.; Stayt, Louise C.; Schutz, Susan; Smith, Christopher M.; Haberstroh, Amanda; Bolin, Linda P.; Taylor, Catherine L.; Moosavi, Shakeeb H.; Bibbey, Adam J Hypertens

Aim: Understanding patients’ hypertension (HTN) symptoms can assist healthcare professionals’ awareness of individual, cultural, and behavioral responses and improve diagnostic accuracy to optimize treatment. The purpose of this review was to evaluate and synthesize current literature exploring (...) -- REVIEWS

7 October

J Hypertens http://journals.lww.com/jhypertension/

07:00
Bidirectional association between SBP variability and arterial stiffness in patients with chronic kidney disease: findings from KNOW-CKD study - Park, Cheol Ho; Kim, Hyung Woo; Park, Jung Tak; Chang, Tae Ik; Yoo, Tae-Hyun; Park, Sue Kyung; Kim, Yeong Hoon; Chae, Dong-Wan; Chung, Wookyung; Oh, Kook-Hwan; Kang, Shin-Wook; Han, Seung Hyeok J Hypertens

Objective: Studies on the mutual relationship between blood pressure (BP) variability and arterial stiffness using time-dependent changes in arterial stiffness are scarce. Methods: In this prospective cohort of Korean patients with chronic kidney disease (CKD) G1-G5 without kidney replacement (...) -- ORIGINAL ARTICLES
07:00
Endothelin type A receptor blockade attenuates aorto-caval fistula-induced heart failure in rats with angiotensin II-dependent hypertension - Kala, Petr; Gawrys, Olga; Miklovi?, Matúš; Va?ourková, Zdenka; Škaroupková, Petra; Jíchová, Šárka; Sadowski, Janusz; Kompanowska-Jezierska, Elzbieta; Walkowska, Agnieszka; Veselka, Josef; Táborský, Miloš; Maxová, Hana; Van??ková, Ivana; ?ervenka, Lud?k J Hypertens

Objective: Evaluation of the effect of endothelin type A (ETA) receptor blockade on the course of volume-overload heart failure in rats with angiotensin II-dependent hypertension. Methods: Ren-2 renin transgenic rats (TGR) were used as a model of hypertension. Heart failure was induced by (...) -- ORIGINAL ARTICLES
07:00
Central blood pressure estimation in type 1 diabetes: impact and implications of peripheral calibration method - Helleputte, Simon; Spronck, Bart; Sharman, James E.; Van Bortel, Luc; Segers, Patrick; Calders, Patrick; Lapauw, Bruno; De Backer, Tine J Hypertens

Objective: Peripheral blood pressure (BP) waveforms are used for noninvasive central BP estimation. Central BP could assist in cardiovascular risk assessment in patients with type 1 diabetes mellitus (T1DM). However, correct calibration of peripheral BP waveforms is important to accurately (...) -- ORIGINAL ARTICLES

4 October

J Hypertens http://journals.lww.com/jhypertension/

07:00
Quadratic relationship between systolic blood pressure and white matter lesions in individuals with hypertension - Woldstad, Christopher; Rusinek, Henry; Sweeney, Elizabeth; Butler, Tracy; Li, Yi; Tanzi, Emily; Mardy, Christopher; Harvey, Patrick; de Leon, Mony J.; Glodzik, Lidia J Hypertens

Background: There is a well documented relationship between cardiovascular risk factors and the development of brain injury, which can lead to cognitive dysfunction. Hypertension (HTN) is a condition increasing the risk of silent and symptomatic ischemic brain lesions. Although benefits of (...) -- ORIGINAL ARTICLES
07:00
Relationship of 24-h ambulatory blood pressure variability with micro and macrovascular parameters and hypertension status - Papadopoulou, Stella-Lida; Gkaliagkousi, Eugenia; Dipla, Konstantina; Koletsos, Nikolaos; Zafeiridis, Andreas; Zabulis, Xenophon; Lazaridis, Antonios; Stergiou, George; Douma, Stella; Triantafyllou, Areti J Hypertens

Objectives: Increased blood pressure variability (BPV) has been associated with an increased risk of subclinical organ damage and cardiovascular events, independently of elevated average BP values. We aimed to investigate the association of BPV indices with micro- and macrovascular parameters, (...) -- ORIGINAL ARTICLES
07:00
Blood pressure reduction cut-points for orthostatic hypotension in stroke survivors using a sit-up test: a multicentre cross-sectional study - Oyake, Kazuaki; Tateishi, Takaki; Murayama, Jun; Shijima, Naoki; Sekizuka, Tasuku; Otaka, Yohei; Momose, Kimito J Hypertens

Objective: The sit-up test is used to assess orthostatic hypotension in stroke survivors who cannot stand independently without using a tilt table. However, no study has identified the optimal cut-points for orthostatic hypotension using the test. Therefore, this study aimed to examine the (...) -- ORIGINAL ARTICLES

19 September

J Hypertens http://journals.lww.com/jhypertension/

07:00
End-diastolic velocity mediates the relationship between renal resistive index and the risk of death - Halimi, Jean-Michel; Vernier, Louis-Marie; Gueguen, Juliette; Goin, Nicolas; Gatault, Philippe; Sautenet, Bénédicte; Barbet, Christelle; Longuet, Hélène; Roumy, Jérôme; Buchler, Matthias; Blacher, Jacques; de Freminville, Jean-Baptiste J Hypertens

Objective: Renal resistive index predicts the risk of death in many populations but the mechanism linking renal resistive index and death remains elusive. Renal resistive index is derived from end-diastolic velocity (EDV) and peak systolic velocity (PSV). However, the predictive value of EDV or (...) -- ORIGINAL ARTICLES
07:00
Sleep and risk of hypertension in general American adults: the National Health and Nutrition Examination Surveys (2015–2018) - Li, Chunnan; Shang, Shaomei; Liang, Wannian J Hypertens

Objective: The purpose of research is to investigate the associations of sleep factors separately and jointly with risk of hypertension. Methods: The National Health and Nutrition Examination Surveys (NHANES) is a nationally representative survey. Participants aged over 20 years with complete (...) -- ORIGINAL ARTICLES

13 September

J Hypertens http://journals.lww.com/jhypertension/

07:00
Genetically predicted blood pressure, antihypertensive drugs and risk of heart failure: a Mendelian randomization study - Lian, Jiao; Shi, Xuezhong; Jia, Xiaocan; Fan, Jingwen; Wang, Yuping; Zhao, Yang; Yang, Yongli J Hypertens

Background: Elevated blood pressure (BP) was associated with higher risk of heart failure, but the relationship between BP-lowering via antihypertensive drugs and diminution of heart failure was inconclusive. This study aimed to estimate the causal association of BP with heart failure, and (...) -- ORIGINAL ARTICLES
07:00
Utilizing 3D printing to facilitate surgical in-situ paediatric renal artery aneurysm repair for refractory hypertension - Chandak, Pankaj; Kessaris, Nicos; Karunanithy, Narayan; Byrne, Nick; Newton, Joanna; Bharadwaj, R.; Assia-Zamora, Sergio; Shenoy, Mohan; Sallam, Morad; Sinha, Manish D. J Hypertens

Renal artery aneurysmal (RAA) disease is a rare, but potentially life-threatening cause of renovascular disease presenting with hypertension. Conventional management involves aneurysmal excision followed by renal auto-transplantation. We present the management of a 13-year-old girl with complex (...) -- CASE REPORT

1 July

J Hypertens http://journals.lww.com/jhypertension/

07:00
The interaction of estimated glomerular filtration rate with circadian blood pressure variation: do not forget the impact of albuminuria - Georgianos, Panagiotis I.; Vaios, Vasilios; Sgouropoulou, Vasiliki; Liakopoulos, Vassilios J Hypertens

No abstract available -- CORRESPONDENCE
07:00
Blood pressure management through application-based telehealth platforms: a systematic review and meta-analysis - Kalagara, Roshini; Chennareddy, Susmita; Scaggiante, Jacopo; Matsoukas, Stavros; Bhimani, Abhiraj; Smith, Colton; Putrino, David; Dangayach, Neha S.; Mocco, J.; Schnipper, Jeffrey L.; Auerbach, Andrew D.; Kellner, Christopher P. J Hypertens

Background and objectives: Hypertension management has several challenges, including poor compliance with medications and patients being lost to follow-up. Recently, remote patient monitoring and telehealth technologies have emerged as promising methods of blood pressure management. We aimed to (...) -- REVIEWS
07:00
Practical guide for the management of hypertensive disorders during pregnancy - Antza, Christina; Stabouli, Stella; Kotsis, Vasilios J Hypertens

Hypertensive disorders of pregnancy, including gestational hypertension, preeclampsia, and eclampsia, are a worldwide health problem. Hypertensive disorders of pregnancy affect more than 10% of pregnancies and are associated with increased mortality and morbidity for both mother and fetus. (...) -- REVIEWS
07:00
Arterial stiffness and renal function decline: are all stiffness measurements equally predictive? - Laurent, Stéphane J Hypertens

No abstract available -- EDITORIAL COMMENTARIES
07:00
Severe COVID-19 infection and cardiovascular disease – a long-term relationship or short myocardial affair? - Motwani, Manish J Hypertens

No abstract available -- EDITORIAL COMMENTARIES
07:00
Prevalence of hypertension and hypertension phenotypes after three visits in Chinese urban children - Dong, Jie; Dong, Hongbo; Yan, Yinkun; Cheng, Hong; Zhao, Xiaoyuan; Mi, Jie J Hypertens

Objective: This study aims to evaluate the prevalence of hypertension and hypertension subtypes among Chinese children aged 6–17 years in a multicenter school-based sample by three separate screenings. Methods: Students from six major cities in China (Changchun, Beijing, Jinan, Shanghai, (...) -- ORIGINAL ARTICLES
07:00
Cardiovascular outcome 6 months after severe coronavirus disease 2019 infection - Raafs, Anne G.; Ghossein, Mohammed A.; Brandt, Yentl; Henkens, Michiel T.H.M.; Kooi, M. Eline; Vernooy, Kevin; Spaanderman, Marc E.A.; Gerretsen, Suzanne; van Santen, Susanne; Driessen, Rob G.H.; Knackstedt, Christian; van der Horst, Iwan C.C.; van Bussel, Bas C.T.; Heymans, Stephane R.B.; Ghossein-Doha, Chahinda J Hypertens

Objectives: In coronavirus disease 2019 (COVID-19), cardiovascular risk factors and myocardial injury relate to increased mortality. We evaluated the extent of cardiac sequelae 6 months after hospital discharge in patients surviving ICU hospitalization for COVID-19. Methods: All survivors of (...) -- ORIGINAL ARTICLES
07:00
Epidemiology and outcomes of hypertensive crisis in patients with chronic kidney disease: a nationwide analysis - Pothuru, Suveenkrishna; Chan, Wan-Chi; Ranka, Sagar; Acharya, Prakash; Mehta, Harsh; Cannon, Chad; Yarlagadda, Sri G.; Shah, Zubair; Gupta, Kamal J Hypertens

Background: The epidemiology and outcomes of hypertensive crisis (HTN-C) in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have not been well studied. The objective of our study is to describe the incidence, clinical characteristics, and outcomes of emergency (...) -- ORIGINAL ARTICLES
07:00
Predictive ability of arterial stiffness parameters for renal function decline: a retrospective cohort study comparing cardio-ankle vascular index, pulse wave velocity and cardio-ankle vascular index0 - Nagayama, Daiji; Fujishiro, Kentaro; Miyoshi, Toru; Horinaka, Shigeo; Suzuki, Kenji; Shimizu, Kazuhiro; Saiki, Atsuhito; Shirai, Kohji J Hypertens

Objective: The relative usefulness of arterial stiffness parameters on renal function remains controversial. This study aimed to compare the predictive ability of three arterial stiffness parameters at baseline; cardio-ankle vascular index (CAVI), heart–ankle pulse wave velocity (haPWV) and (...) -- ORIGINAL ARTICLES
07:00
Transcriptomics of angiotensin II-induced long noncoding and coding RNAs in endothelial cells - Bu, Shuhan; Nguyen, Hien C.; Michels, David C.R.; Rasheed, Berk; Nikfarjam, Sepideh; Singh, Rohan; Wang, Lynn; Patel, Darshil A.; Singh, Shweta; Qadura, Mohammad; Singh, Krishna K. J Hypertens

Objective: Angiotensin II (Ang II)-induced endothelial dysfunction plays an important role in the pathogenesis of cardiovascular diseases such as systemic hypertension, cardiac hypertrophy and atherosclerosis. Recently, long noncoding RNAs (lncRNAs) have been shown to play an essential role in (...) -- ORIGINAL ARTICLES
07:00
Sirtuin1 inhibitor attenuates hypertension in spontaneously hypertensive rats: role of Gi? proteins and nitroxidative stress - Arifen, Nahida; Li, Yuan; Srivastava, Ashok K.; Anand-Srivastava, Madhu B. J Hypertens

Background: We recently showed that vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHR) exhibit overexpression of Sirtuin1 (Sirt1) that contributes to the enhanced expression of Gi? proteins implicated in the development of hypertension in SHR. Method: The present (...) -- ORIGINAL ARTICLES
07:00
Prevalence and associated factors of obstructive sleep apnea in refractory hypertension - Chedier, Bernardo; Roderjan, Christian N.; Cavalcanti, Aline H.; de Souza, Fabio; Muxfeldt, Elizabeth S. J Hypertens

Background: Refractory hypertension (RfHT) and obstructive sleep apnea (OSA) share common pathophysiological mechanisms and probably are intrinsically associated, but their prevalence, clinical profile, and polysomnography (PSG) pattern remain misunderstood. Objective: To describe OSA (...) -- ORIGINAL ARTICLES
07:00
Association of home and office systolic and diastolic hypertension with glucose metabolism in a general population: the Ohasama study - Tatsumi, Yukako; Satoh, Michihiro; Asayama, Kei; Murakami, Takahisa; Hirose, Takuo; Hara, Azusa; Tsubota-Utsugi, Megumi; Inoue, Ryusuke; Kikuya, Masahiro; Nomura, Kyoko; Metoki, Hirohito; Hozawa, Atsushi; Katagiri, Hideki; Imai, Yutaka; Ohkubo, Takayoshi J Hypertens

Objective: This study was performed to investigate the association of hypertension subtypes with glucose metabolism among the Japanese general population. Methods: The study involved 646 residents (mean age: 62.4 years) without treatment for hypertension or a history of diabetes from Ohasama, a (...) -- ORIGINAL ARTICLES
07:00
Association of ambulatory blood pressure with aortic valve and coronary artery calcification - Sawayama, Yuichi; Hisamatsu, Takashi; Kadota, Aya; Torii, Sayuki; Kondo, Keiko; Fujiyoshi, Akira; Higo, Yosuke; Harada, Akiko; Watanabe, Yoshiyuki; Nakagawa, Yoshihisa; Miura, Katsuyuki; Ueshima, Hirotsugu J Hypertens

Objective: We aimed to investigate the effect of ambulatory blood pressure (BP) on aortic valve calcification (AVC) and coronary artery calcification (CAC), which are subclinical atherosclerotic diseases. Methods: In this population-based, cross-sectional study, we assessed office BP, mean (...) -- ORIGINAL ARTICLES
07:00
Association of gestational hypertension and preeclampsia with nonsyndromic orofacial clefts in China: a large prospective cohort study - An, Hang; Jin, Ming; Li, Zhiwen; Zhang, Le; Zhang, Yali; Li, Hongtian; Liu, Jianmeng; Ye, Rongwei; Li, Nan J Hypertens

Background: The associations between hypertensive disorders of pregnancy and nonsyndromic orofacial clefts (NSOFCs) are not consistent or based on case–control study design. We hypothesize that OFCs and NSOFCs are associated with hypertensive disease in pregnancy. Methods: Data were collected (...) -- ORIGINAL ARTICLES
07:00
Lifestyle modification and cognitive function among individuals with resistant hypertension: cognitive outcomes from the TRIUMPH trial - Smith, Patrick J.; Sherwood, Andrew; Hinderliter, Alan L.; Mabe, Stephanie; Watkins, Lana L.; Craighead, Linda; Ingle, Krista; Tyson, Crystal; Avorgbedor, Forgive; Lin, Pao-Hwa; Kraus, William E.; Liao, Lawrence; Blumenthal, James A. J Hypertens

Background: Resistant hypertension is associated with increased risk of cognitive decline, stroke, and dementia. Lifestyle modification has been suggested to improve cognitive function through its salutary effects on vascular function. Methods: Participants included 140 patients with resistant (...) -- ORIGINAL ARTICLES
07:00
Disparities between determinants of impaired vascular structure and function in young people with primary hypertension: a systematic review - Azukaitis, Karolis; Sinha, Manish D.; Obrycki, ?ukasz; Pac, Micha?; Bjelakovic, Bojko; Jankauskiene, Augustina; Litwin, Mieczys?aw J Hypertens

Objective: Early effects of primary hypertension on arterial structure and function in children and young people (CYP) and their determinants remain elusive. We aimed to review independent determinants of carotid intima–media thickness (cIMT), carotid wall cross-sectional area (WCSA) and (...) -- ORIGINAL ARTICLES
07:00
Home blood pressure monitoring schedule: optimal and minimum based on 2122 individual participants’ data - Kyriakoulis, Konstantinos G.; Ntineri, Angeliki; Niiranen, Teemu J.; Lindroos, Annika; Jula, Antti; Schwartz, Claire; Kollias, Anastasios; Andreadis, Emmanuel A.; McManus, Richard J.; Stergiou, George S. J Hypertens

Objectives: Home blood pressure (HBP) monitoring has become a primary method for hypertension diagnosis and management. This analysis aimed to investigate the optimal and minimum schedule for HBP monitoring. Methods: A retrospective analysis of cross-sectional data was performed, which involved (...) -- ORIGINAL ARTICLES
07:00
Association between genetic risk of high SBP and hypertension control: the CoLaus|PsyColaus study - Marques-Vidal, Pedro; Chekanova, Valeriya; Vaucher, Julien J Hypertens

Objective: To assess whether a genetic risk score (GRS) for high SBP is associated with poor control of hypertension. Methods: Data from the four waves of a population-based, prospective study conducted in Lausanne, Switzerland. Control of hypertension was defined based on SBP less than 140 (...) -- ORIGINAL ARTICLES
07:00
Distinct transcriptomic profile of small arteries of hypertensive patients with chronic kidney disease identified miR-338-3p targeting GPX3 and PTPRS - Berillo, Olga; Huo, Ku-Geng; Richer, Chantal; Fraulob-Aquino, Júlio C.; Briet, Marie; Lipman, Mark L.; Sinnett, Daniel; Paradis, Pierre; Schiffrin, Ernesto L. J Hypertens

Objective: Hypertension is associated with vascular injury, which contributes to end-organ damage. MicroRNAs regulating mRNAs have been shown to play a role in vascular injury in hypertensive mice. We aimed to identify differentially expressed microRNAs and their mRNA targets in small arteries (...) -- ORIGINAL ARTICLES
07:00
Spot urinary sodium to monitor relative changes in population salt intake during the UK salt reduction programme - Tan, Monique; Wang, Changqiong; Song, Jing; He, Feng J.; MacGregor, Graham A. J Hypertens

Objectives: The most accurate method to measure population salt intake is to collect the complete 24-h urinary sodium excretion (24-h UNa) but it is resource intensive and is rarely carried out frequently. We, therefore, assessed the use of spot urinary sodium concentration to monitor relative (...) -- ORIGINAL ARTICLES
07:00
Barriers to up-titrated antihypertensive strategies in 12 sub-Saharan African countries: the Multination Evaluation of hypertension in Sub-Saharan Africa Study - Cavagna, Pauline; Kramoh, Kouadio Euloge; Diop, Ibrahima Bara; Kouam Kouam, Charles; Ikama, Meo Stéphane; Takombe, Jean Laurent; Damorou, Jean Marie; Ali Toure, Ibrahim; Balde, Dadhi M.; Dzudie, Anastase; Khoury, Stéphanie; Perier, Marie Cécile; Asselin, Anouk; Azizi, Michel; Houenassi, Martin Dèdonougbo; Kane, Abdoul; Kimbally-Kaki, Suzy Gisèle; Kingue, Samuel; Limbole, Emmanuel; Mfeukeu Kuate, Liliane; Mipinda, Jean Bruno; Ferreira, Beatriz; Nhavoto, Carol; Sidy Ali, Abdallahi; Empana, Jean Philippe; N’guetta, Roland; Jouven, Xavier; Antignac, (...) J Hypertens

Background: Sub-Saharan Africa (SSA) faces the highest rate of hypertension worldwide. The high burden of elevated blood pressure (BP) in black people has been emphasized. Guidelines recommend two or more antihypertensive medications to achieve a BP control. We aimed to identify factors (...) -- ORIGINAL ARTICLES
07:00
Role of the angiotensin type 1 receptor in modulating the carotid chemoreflex in an ovine model of renovascular hypertension - Sohn, Chris Sung-Eun; Chang, Joshua Wen-Han; George, Bindu; Chen, Siyi; Ramchandra, Rohit J Hypertens

Objective: The carotid body has been implicated as an important mediator and putative target for hypertension. Previous studies have indicated an important role for angiotensin II in mediating carotid body function via angiotensin type-1 receptors (AT1R); however, their role in modulating (...) -- ORIGINAL ARTICLES
07:00
Aortic root dilatation and aortic stiffness - Murakami, Tomoaki; Shiraishi, Masahiro; Niwa, Koichiro J Hypertens

No abstract available -- CORRESPONDENCE
07:00
The sex difference in the association of enhanced brachial–ankle pulse wave velocity and adverse cardiac remodeling: the possible background mechanism - Murakami, Tomoaki; Shiraishi, Masahiro J Hypertens

No abstract available -- CORRESPONDENCE

1 June

J Hypertens http://journals.lww.com/jhypertension/

07:00
Reproducibility of masked hypertension and office-based hypertension: a systematic review and meta-analysis - Antza, Christina; Farmakis, Ioannis; Doundoulakis, Ioannis; Akrivos, Evangelos; Stalikas, Nikolaos; Zafeiropoulos, Stefanos; Kostopoulos, Georgios; Stabouli, Stella; Giannakoulas, George; Kotsis, Vasilios J Hypertens

Blood pressure (BP) phenotypes have a prognostic significance for target organ damage in long-term studies. However, it remains uncertain whether a single baseline phenotype classification is reproducible over time and represents accurately the patients’ BP status. The aim of this study was to (...) -- REVIEW
07:00
Blood pressure variability and structural brain changes: a systematic review - Gutteridge, Daria S.; Tully, Phillip J.; Ghezzi, Erica S.; Jamadar, Sharna; Smith, Ashleigh E.; Commerford, Toby; Keage, Hannah A.D. J Hypertens

Background: Blood pressure variability (BPV) has been linked with cognitive impairment and dementia. However, the pathophysiological mechanisms by which BPV affects cognition are unclear. This systematic review aims to assess the links between different BPV measures and white and grey matter (...) -- REVIEW
07:00
Effect of different treatments for obstructive sleep apnoea on blood pressure - Kou, Chengkun; Zhao, Xu; Lin, Xin; Fan, Xin; Wang, Qiongying; Yu, Jing J Hypertens

Objective: Obstructive sleep apnoea (OSA) is a common cause of secondary hypertension. This network meta-analysis (NMA) assessed the effect of different OSA treatments on lowering blood pressure. Methods: PubMed, EMBASE, Web of Science, and Cochrane Library databases were searched for relevant (...) -- REVIEW
07:00
Known unknowns of sex differences in cardiovascular physiology: can arterial waveforms provide answers? - Picone, Dean S.; Mayer, Christopher C.; Climie, Rachel E. J Hypertens

No abstract available -- EDITORIAL
07:00
From epidemiological observations to clinical practice: is the measure of postural blood pressure abnormal changes the new vital sign? - Mattace-Raso, Francesco J Hypertens

No abstract available -- EDITORIAL COMMENT
07:00
Inter-individual variations in response to aerobic and resistance training in hypertensive older adults - Abrahin, Odilon; Abrahin, Rejane Pequeno; de Sousa, Evitom Corrêa; Cortinhas-Alves, Erik Artur; Nascimento, Dahan da Cunha; Guerreiro, João Farias J Hypertens

Background: Hemodynamic responses to physical training are not homogenous and uniform, and considerable inter-individual variations in the blood pressure of hypertensive individuals are noted in both aerobic and resistance training protocols. In this context, this study aimed to evaluate the (...) -- ORIGINAL ARTICLES
07:00
Aortic diastolic pressure decay explains sex-related differences in the subendocardial viability ratio: the Wakuya study - Tagawa, Kaname; Tsuru, Yusuke; Yokoi, Katsumi; Aonuma, Takanori; Hashimoto, Junichiro J Hypertens

Objective: Coronary heart disease is the leading cause of mortality in women. Despite a higher risk of heart failure after the first myocardial infarction in women compared with men, the sex-specific mechanisms are unknown. We hypothesized that myocardial ischemia is attributable to sex-related (...) -- ORIGINAL ARTICLES
07:00
Orthostatic hypotension and mortality risk in geriatric outpatients: the impact of duration and magnitude of the blood pressure drop - Wiersinga, Julia H.I.; Muller, Majon; Rhodius-Meester, Hanneke F.M.; De Kroon, Renske M.; Peters, Mike J.L.; Trappenburg, Marijke C. J Hypertens

Introduction: Orthostatic hypotension is a common condition associated with an increased mortality risk. This study investigates this association specifically in geriatric outpatients and additionally focuses on the duration and magnitude of orthostatic hypotension. Methods: In this (...) -- ORIGINAL ARTICLES
07:00
Persistent vascular dysfunction following an acute nonpharmacological reduction in blood pressure in hypertensive patients - Fermoyle, Caitlin C.; Broxterman, Ryan M.; La Salle, D. Taylor; Ratchford, Stephen M.; Hopkins, Paul N.; Richardson, Russell S.; Trinity, Joel D. J Hypertens

Background: Vascular dysfunction, an independent risk factor for cardiovascular disease, often persists in patients with hypertension, despite improvements in blood pressure control induced by antihypertensive medications. Methods: As some of these medications may directly affect vascular (...) -- ORIGINAL ARTICLES
07:00
A bibliometric analysis of the research on preeclampsia in the first two decades of the twenty-first century - Zheng, Dongying; Khan, Muhanmmad; Zhang, Guangyao; Song, Kedong; Wang, Lixia; Qiao, Chong; Kang, Fuli J Hypertens

Background: Preeclampsia still remains one of the leading causes of maternal and perinatal mortality worldwide. Despite the concerted efforts of researchers, only a little improvement has been seen. Clinical decision-making is based on the published literatures. With the explosive growth of (...) -- ORIGINAL ARTICLES
07:00
Impact of estimated pulse wave velocity and socioeconomic status on the risk of stroke in men: a prospective cohort study - Jae, Sae Young; Heffernan, Kevin S.; Kim, Hyun Jeong; Kunutsor, Setor K.; Fernhall, Bo; Kurl, Sudhir; Laukkanen, Jari A. J Hypertens

Objective: High pulse wave velocity (PWV) and low socioeconomic status (SES) are each associated with increased risk of stroke, but clarification of the interplay between PWV, SES and the risk of stroke appears to be warranted to identify vulnerable populations at high risk of stroke. We (...) -- ORIGINAL ARTICLES
07:00
Influences of achieved SBP on age and sex-related left ventricular structural alteration in community hypertensive populations - Cai, Anping; Liu, Lin; Zhou, Dan; Tang, Songtao; Zhou, Yingling; Feng, Yingqing J Hypertens

Objective: To evaluate age and sex-related left ventricular (LV) structural alteration in community hypertensive populations, and to explore whether achieved systolic blood pressure (SBP) (< 120, < 130 and -- ORIGINAL ARTICLES
07:00
11C-Metomidate PET-CT versus adrenal vein sampling to subtype primary aldosteronism: a prospective clinical trial - Puar, Troy H.; Khoo, Chin Meng; Tan, Colin Jingxian; Tong, Aaron Kian Ti; Tan, Michael Chien Sheng; Teo, Ada Ee Der; Ng, Keng Sin; Wong, Kang Min; Reilhac, Anthonin; O’Doherty, Jim; Gomez-Sanchez, Celso E.; Kek, Peng Chin; Yee, Szemen; Tan, Alvin W.K.; Chuah, Matthew Bingfeng; Lee, Daphne Hui Min; Wang, Kuo Weng; Zheng, Charles Qishi; Shi, Luming; Robins, Edward George; Foo, Roger Sik Yin J Hypertens

Objective: Adrenal vein sampling (AVS) is recommended to subtype primary aldosteronism, but it is technically challenging. We compared 11C-Metomidate-PET-computed tomography (PET-CT) and AVS for subtyping of primary aldosteronism. Methods: Patients with confirmed primary aldosteronism underwent (...) -- ORIGINAL ARTICLES
07:00
Hypoxia regulates fibrosis-related genes via histone lactylation in the placentas of patients with preeclampsia - Li, Xiang; Yang, Nana; Wu, Yue; Wang, Xuegu; Sun, Junpei; Liu, Lei; Zhang, Feng; Gong, Yingying; Zhang, Yan; Li, Xueting; Du, Danli; Ding, Biao J Hypertens

Background: Histone lactylation, a novel epigenetic modification induced by hypoxia and lactate, plays an important role in regulating gene expression. However, the role of histone lactylation in the pathogenesis of preeclampsia remains unknown. Methods: Placentas from preeclamptic patients and (...) -- ORIGINAL ARTICLES
07:00
Can ?-blockers influence regular daily physical activity? - Alimento, Marina Luisa; Palermo, Pietro; Italiano, Gianpiero; Antonioli, Laura; Salvioni, Elisabetta; Agostoni, Piergiuseppe J Hypertens

Background: In hypertension, ?-blockers have a high rate of nonadherence to treatment likely because of fatigue. Methods: We evaluate daily physical activity and maximal exercise performance in 56 patients with hypertension (grades I–II), with and without ?-blockers (bisoprolol 10 mg or atenolol (...) -- ORIGINAL ARTICLES
07:00
Persistent cardiac organ damage in surgically and medically treated primary aldosteronism - Aune, Arleen; Gerdts, Eva; Kokorina, Marina; Kringeland, Ester; Midtbø, Helga; Løvås, Kristian; Grytaas, Marianne A. J Hypertens

Objective: We compared persistent cardiac organ damage in patients treated surgically or medically for primary aldosteronism. Methods: Eighty-four patients (age 57 ± 11 years, 27% women) with primary aldosteronism underwent echocardiography at time of diagnosis and after one year of treatment (...) -- ORIGINAL ARTICLES
07:00
Associations of maternal periconceptional alcohol consumption with offspring prehypertension/hypertension at age 6 years: the Growing Up in Singapore Towards healthy Outcomes prospective mother-offspring cohort study - Sadananthan, Suresh Anand; Michael, Navin; Tint, Mya Thway; Thirumurugan, Kashthuri; Yuan, Wen Lun; Ong, Yi Ying; Law, Evelyn; Choo, Jonathan; Ling, Lieng Hsi; Shek, Lynette; Fabian, Yap; Tan, Kok Hian; Vickers, Mark; Godfrey, Keith M.; Gluckman, Peter D.; Chong, Yap Seng; Fortier, Marielle; Lee, Yung Seng; Eriksson, Johan G.; Chan, Shiao-Yng; Moritz, Karen; Velan, S. Sendhil; Wlodek, Mary E. J Hypertens

Objective: To evaluate the relationship of the levels of maternal alcohol consumption during the 1 year before pregnancy recognition with childhood cardiorenal, metabolic, and neurocognitive health. Methods: In 1106 women and their children from the Growing Up in Singapore Towards healthy (...) -- ORIGINAL ARTICLES
07:00
New theory about the pathophysiology of preeclampsia derived from the paradox of positive effects of maternal smoking - Ekblad, Mikael O.; Gissler, Mika; Korhonen, Päivi E. J Hypertens

Objective: The aim of this study was to evaluate if maternal height affects the link between the inverse association on smoking during pregnancy and preeclampsia. Study design: The study population consisted of all women with singleton pregnancies (n = 803 698) in Finland during the years (...) -- ORIGINAL ARTICLES
07:00
Prevalence, time-trends and clinical characteristics of hypertension in young adults: nationwide cross-sectional study of 1.7 million Swedish 18-year-olds, 1969–2010 - Rietz, Helene; Pennlert, Johanna; Nordström, Peter; Brunström, Mattias J Hypertens

Objective: The prevalence of hypertension in young adulthood, as well as the clinical characteristics associated with different hypertension subtypes, have been inconsistently described. Our aim was to assess the prevalence, time-trends and characteristics associated with isolated systolic (...) -- ORIGINAL ARTICLES
07:00
A case of novel mutation of Cullin 3 gene in pseudohypoaldosteronism type II - Wang, Liang; Nie, Muwen; Guo, Fan; Tian, Zhuang; Guo, Xiaoxiao; Zhang, Shuyang J Hypertens

Pseudohypoaldosteronism type II (PHA II) is a rare inherited disease characterized by hypertension, hyperkalemia and metabolic acidosis. With the development of gene sequencing technology, more genetic mutations underlying PHA II were reported and the understanding of its pathogenesis has gone (...) -- CASE REPORT
07:00
Blood pressure during moderate or maximal exercise: hardly two sides of the same coin - Mariampillai, Julian E.; Kjeldsen, Sverre E.; Gjesdal, Knut; Skretteberg, Per Torger J Hypertens

No abstract available -- CORRESPONDENCE
07:00
Reply to ‘Blood pressure during moderate or maximal exercise: hardly two sides of the same coin’ - Hedman, Kristofer; Lindow, Thomas; Cauwenberghs, Nicholas; Carlén, Anna; Elmberg, Viktor; Brudin, Lars; Ekström, Magnus J Hypertens

No abstract available -- CORRESPONDENCE
07:00
Pulse pressure amplification is one of the important factors evaluating peripheral blood pressure during exercise - Murakami, Tomoaki; Shiraishi, Masahiro J Hypertens

No abstract available -- CORRESPONDENCE
07:00
Reply to ‘Pulse pressure amplification is one of the important factors evaluating peripheral blood pressure during exercise’ - Hedman, Kristofer; Lindow, Thomas; Cauwenberghs, Nicholas; Carlén, Anna; Elmberg, Viktor; Brudin, Lars; Ekström, Magnus J Hypertens

No abstract available -- CORRESPONDENCE
07:00
Reply to ‘Known unknowns of sex differences in cardiovascular physiology – can arterial waveforms provide answers?’ - Tagawa, Kaname; Hashimoto, Junichiro J Hypertens

No abstract available -- CORRESPONDENCE
07:00
Impact of early glomerular filtration rate decline in response to antihypertensive treatment on risk of end-stage kidney disease and cardiovascular outcomes: a systematic review and meta-analysis: Erratum J Hypertens

No abstract available -- ERRATUM

1 May

J Hypertens http://journals.lww.com/jhypertension/

07:00
Nebivolol and incident cardiovascular events in hypertensive patients compared with nonvasodilatory beta blockers - Huck, Daniel M.; Rosenberg, Michael A.; Stauffer, Brian L. J Hypertens

Objective: Nonvasodilatory beta blockers are associated with inferior cardiovascular event reduction compared with other antihypertensive classes, and there is uncertainty about first-line use of beta blockers for hypertension in guidelines. The third generation vasodilatory beta blocker (...) -- ORIGINAL ARTICLES
07:00
Small RNA sequencing reveals placenta-derived exosomal microRNAs associated with preeclampsia - Lu, Jing; Sun, Yifan; Cao, Yuming; Zhang, Yuanzhen J Hypertens

Objective: Preeclampsia is one of the most important complications during pregnancy and the leading cause of maternal morbidity and mortality; however, the pathogenesis of preeclampsia remains partially misunderstood. The aim of this study was to identify placenta-derived exosomal microRNAs (...) -- ORIGINAL ARTICLES
07:00
Exaggerated natriuresis after renal artery balloon angioplasty for flash pulmonary oedema: a potential complication in one-kidney renovascular hypertension - Schwillens, Evelien J.M.; Mostard, Guy J.M.; Stifft, Frank; van Twist, Daan J.L. J Hypertens

Flash pulmonary oedema is a life-threatening complication of renal artery stenosis. We report a very rare complication in a patient with bilateral atherosclerotic renal artery stenosis who underwent unilateral renal artery angioplasty because of recurrent flash pulmonary oedema. Shortly after (...) -- CASE REPORT
07:00
Prescribing blood pressure lowering drugs irrespective of blood pressure? - Kreutz, Reinhold; Brunström, Mattias; Thomopoulos, Costas; Carlberg, Bo; Mancia, Giuseppe J Hypertens

No abstract available -- CORRESPONDENCE
07:00
Diuretics at bedtime hypertension treatment - Stoschitzky, Kurt J Hypertens

No abstract available -- CORRESPONDENCE
07:00
Do recent meta-analyses truly prove that treatment with blood pressure-lowering drugs is beneficial at any blood pressure value, no matter how low? A critical review - Kreutz, Reinhold; Brunström, Mattias; Thomopoulos, Costas; Carlberg, Bo; Mancia, Giuseppe J Hypertens

Current European guidelines for the management of hypertension and on cardiovascular disease prevention place the threshold for pharmacological treatment at a SBP level of 140 mmHg or above, with the exception of patients at very high risk (mainly because of coronary heart disease). This is in (...) -- REVIEWS
07:00
The Blood Pressure Lowering Treatment Trialists’ Collaboration: methodological clarifications of recent reports - Nazarzadeh, Milad; Canoy, Dexter; Bidel, Zeinab; Copland, Emma; Rahimi, Kazem; Teo, Koon; Davis, Barry R.; Chalmers, John; Pepine, Carl J.; Woodward, Mark J Hypertens

Epidemiological evidence has consistently shown that people with higher systolic or diastolic blood pressure are at greater risk of cardiovascular diseases. However, there has been limited randomized evidence to determine the role of blood pressure level at treatment initiation in the reduction (...) -- REVIEWS
07:00
Which domains of the theoretical domains framework should be targeted in interventions to increase adherence to antihypertensives? A systematic review - Rahman, Murshida; Judah, Gaby; Murphy, Dan; Garfield, Sara F. J Hypertens

Nonadherence to antihypertensives is prevalent and is associated with poorer health outcomes. This study aimed to identify psychological factors associated with adherence in patients taking antihypertensives as these are potentially modifiable, and can, therefore, inform the development of (...) -- REVIEWS
07:00
A qualitative assessment of Florida's Heart/Lung Bill - Minocha, Geeta J Hypertens

No abstract available -- EDITORIAL
07:00
Association between urinary sodium-to-potassium ratio and home blood pressure and ambulatory blood pressure: the Ohasama study - Muroya, Tomoko; Satoh, Michihiro; Murakami, Takahisa; Nakayama, Shingo; Asayama, Kei; Hirose, Takuo; Tatsumi, Yukako; Inoue, Ryusuke; Tsubota-Utsugi, Megumi; Hara, Azusa; Kogure, Mana; Nakaya, Naoki; Nomura, Kyoko; Kikuya, Masahiro; Metoki, Hirohito; Imai, Yutaka; Hozawa, Atsushi; Ohkubo, Takayoshi J Hypertens

Objective: No studies have demonstrated the association between urinary sodium-to-potassium (Na/K) ratio and all out-of-office blood pressure (BP) [home morning and evening BP (self-measured at home), and 24-h, daytime, and night-time ambulatory BP] in the same cohort. We aimed to assess, which (...) -- ORIGINAL ARTICLES
07:00
Arterial stiffness throughout pregnancy: Arteriograph device-specific reference ranges based on a low-risk population - Anness, Abigail R.; Nath, Mintu; Melhuish, Kess; Osman, Mohammed W.; Webb, David; Robinson, Thompson; Khalil, Asma; Mousa, Hatem A. J Hypertens

Objective: The maternal cardiovascular system undergoes significant adaptation during pregnancy. We aimed to examine the changes in arterial stiffness parameters during normal pregnancy and establish reference ranges for the general population. Methods: We performed a prospective (...) -- ORIGINAL ARTICLES
07:00
Effect of body size and intensive blood pressure management on cardiovascular and serious adverse events - Pei, Junyu; Wang, Xiaopu; Zheng, Keyang; Su, Wen; Hu, Xinqun J Hypertens

Background: Previous studies have shown that obese hypertensive patients have a lower risk of cardiovascular events than normal-weight patients, and that the performed hypertension treatment affects cardiovascular outcomes depending on the patient's body size. This study aimed to investigate (...) -- ORIGINAL ARTICLES
07:00
Characteristics, treatment, and control of hypertension in public primary healthcare centers in Nigeria: baseline results from the Hypertension Treatment in Nigeria Program - Ojji, Dike B.; Baldridge, Abigail S.; Orji, Ikechukwu A.; Shedul, Gabriel L.; Ojo, Tunde M.; Ye, Jiancheng; Chopra, Aashima; Ale, Boni M.; Shedul, Grace; Ugwuneji, Eugenia N.; Egenti, Nonye B.; Aluka-Omitiran, Kasarachi; Okoli, Rosemary C.B.; Eze, Helen; Nwankwo, Ada; Banigbe, Bolanle; Tripathi, Priya; Kandula, Namratha R.; Hirschhorn, Lisa R.; Huffman, Mark D. J Hypertens

Background: There are limited data on large-scale, multilevel implementation research studies to improve hypertension diagnosis, treatment, and control rates at the primary healthcare (PHC) level in Africa. We describe the characteristics, treatment, and control rates of patients with (...) -- ORIGINAL ARTICLES
07:00
The association between socioeconomic status and prevalence, awareness, treatment and control of hypertension in different ethnic groups: the Healthy Life in an Urban Setting study - Blok, Sebastiaan; Haggenburg, Sabine; Collard, Didier; Van Der Linden, Eva L.; Galenkamp, Henrike; Charante, Eric P. Moll Van; Agyemang, Charles; Van Den Born, Bert-Jan H. J Hypertens

Background: Socioeconomic status (SES) and ethnicity are both important determinants of hypertension prevalence and control rates but their separate contribution is unknown. We assessed the association of SES with hypertension prevalence, awareness, treatment and control, and whether this (...) -- ORIGINAL ARTICLES
07:00
Adrenal BORDeAux reGistry: Bordeaux single-center study of hypertensive patients with primary hyperaldosteronism - Benoit, Julie; Gaudissard, Julie; Doublet, Julien; Boulestreau, Romain; Robert, Grégoire; Brossaud, Julie; Gosse, Philippe; Cremer, Antoine J Hypertens

Background: Primary aldosteronism is responsible for a major cardiovascular risk that can be avoided by specific treatment. A better characterization of the hypertensive population with primary aldosteronism would not only improve the overall diagnosis but also allows a better selection of (...) -- ORIGINAL ARTICLES
07:00
Clinical variables accompanying salt-sensitive essential hypertension in ethnic Kashmiri population - Chachoo, Javaid; Mushtaq, Nausheen; Jan, Sami; Majid, Sabhiya; Mohammad, Iqbal J Hypertens

Background: Salt sensitivity is actually a measure of an individual's blood pressure response to salt intake. It has been reported that people who are salt sensitive have high prevalence of hypertension and target organ damage. The link between dietary salt intake and hypertension is well (...) -- ORIGINAL ARTICLES
07:00
Application of the 2017 American college of cardiology/American Heart Association Blood Pressure Guidelines for cardiovascular outcomes among Tehranian residents - Zadeh, Seyed Saeed Tamehri; Moazzeni, Seyyed Saeed; Matsushita, Kunihiro; Hasheminia, Mitra; Azizi, Fereidoun; Hadaegh, Farzad J Hypertens

Objective(s): To evaluate the associations of cardiovascular disease (CVD) outcomes with elevated blood pressure (BP), stage I of isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and systolic diastolic hypertension (SDH), defined by 2017 ACC/AHA guidelines among the (...) -- ORIGINAL ARTICLES
07:00
Association of arterial stiffness with coronary artery calcium score in the general-population: the Swedish CArdioPulmonary bioImage study - Muhammad, Iram Faqir; Engvall, Jan E.; Persson, Margaretha; Borné, Yan; Nilsson, Peter M.; Östgren, Carl Johan; Engström, Gunnar J Hypertens

Objectives: Coronary artery calcium score (CACS) is a marker of subclinical atherosclerosis. However, there is little data related to the association between arterial stiffness and CACS in the general population. The aim of this study was to explore the association between carotid femoral-pulse (...) -- ORIGINAL ARTICLES
07:00
Higher SBP in female patients with mitochondrial disease - Viering, Daan H.H.M.; van Borselen, Marjolein D.; Deinum, Jaap; Bindels, Rene J.M.; de Baaij, Jeroen H.F.; Janssen, Mirian C.H. J Hypertens

Background: Previous research suggests that hypertension is more prevalent among patients with mitochondrial diseases. Blood pressure (BP) is linearly related to increased cardiovascular risk, and this relationship is strongest for SBP; nevertheless, studies on SBP and DBP in mitochondrial (...) -- ORIGINAL ARTICLES
07:00
Associations between duration and volume of muscle-strengthening exercise and clinically assessed hypertension among 10 519 UK adults: a cross-sectional study - Shakespear-Druery, Jane; De Cocker, Katrien; Biddle, Stuart J.H.; Bennie, Jason J Hypertens

Background: Clinical evidence shows that muscle-strengthening exercise (MSE) is important for the treatment and management of hypertension. However, the links between MSE and hypertension in epidemiological research are currently poorly understood. This study examines the association between (...) -- ORIGINAL ARTICLES
07:00
Cardiorenai protective effects of sodium-glucose cotransporter 2 inhibition in combination with angiotensin II type 1 receptor blockade in salt-sensitive Dahl rats - Ito, Hiromasa; Okamoto, Ryuji; Ali, Yusuf; Zhe, Ye; Katayama, Kan; Ito, Masaaki; Dohi, Kaoru J Hypertens

Objective: The kidney plays a central role in regulating the salt sensitivity of blood pressure (BP) by governing sodium excretion and reabsorption via renal sodium transporters. We hypothesized that sodium-glucose cotransporter 2 (SGLT2) inhibition and angiotensin II type 1 receptor (AT1R) (...) -- ORIGINAL ARTICLES
07:00
The impact of maternal hyperglycaemia first detected in pregnancy on offspring blood pressure in Soweto, South Africa - Boerstra, Brittany A.; Soepnel, Larske M.; Nicolaou, Veronique; Kolkenbeck-Ruh, Andrea; Kagura, Juliana; Ware, Lisa J.; Norris, Shane A.; Klipstein-Grobusch, Kerstin J Hypertens

Background: The long-term consequences for offspring born to mothers with hyperglycaemia first detected in pregnancy (HFDP) are not yet well understood and its influence on childhood blood pressure has not previously been assessed in sub-Saharan Africa. Objective: The objective of this study (...) -- ORIGINAL ARTICLES
07:00
Increased mortality with intensive control in patients with higher baseline SBP and lower Framingham risk - Pan, Heng-Yu; Lin, Hung-Ju; Chen, Wen-Jone; Wang, Tzung-Dau J Hypertens

Objective: In the Systolic Blood Pressure Intervention Trial (SPRINT), the relative reduction in primary outcome with intensive blood pressure (BP) control was numerically smallest in the highest baseline SBP tertile. In this post hoc analysis of SPRINT, the goal was to explore whether the (...) -- ORIGINAL ARTICLES
07:00
Isolated systolic hypertension is associated with increased left ventricular mass index and aortic stiffness in adolescents: a cardiac magnetic resonance study - Sarnecki, J?drzej; Obrycki, ?ukasz; Feber, Janusz; Che?stowska, Sylwia; Jurkiewicz, El?bieta; Litwin, Mieczys?aw J Hypertens

Objectives: Despite the high prevalence of isolated systolic hypertension (ISH) among hypertensive adolescents, its clinical significance is not determined. In addition, it is hypothesized that ISH with normal central blood pressure (BP) in young patients is a benign phenomenon and was hence (...) -- ORIGINAL ARTICLES
07:00
Effects of different doses of canagliflozin on blood pressure and lipids in patients with type 2 diabetes: a meta-analysis - Geng, Qiang; Hou, Fangjie; Zhang, Yonghuan; Wang, Zhengzhong; Zhao, Meiling J Hypertens

Background: Canagliflozin is a sodium glucose-cotransporter-2 receptor inhibitor approved for the treatment of type 2 diabetes mellitus (T2DM). However, it is less prescribed due to increased LDL cholesterol (LDL-C), high incidence of urinary tract infection (UTI), high cost. Data on the effect (...) -- ORIGINAL ARTICLES
07:00
Association between placental global DNA methylation and blood pressure during human pregnancy - Putra, Sulistyo E. Dwi; Reichetzeder, Christoph; von Websky, Karoline; Neuber, Corinna; Halle, Horst; Kleuser, Burkard; Krämer, Bernhard K.; Hocher, Berthold J Hypertens

Objective: Gene-specific placental DNA methylation patterns differ between normal pregnancies and pregnancies complicated by hypertension. However, whether global placental DNA methylation is associated with maternal blood pressure remains controversial. Methods: Using multiple linear (...) -- ORIGINAL ARTICLES
07:00
Hypertension determinants among Ghanaians differ according to location of residence: RODAM study - van der Linden, Eva L.; Meeks, Karlijn A.C.; Klipstein-Grobusch, Kerstin; Bahendeka, Silver; Beune, Erik J.A.J.; van den Born, Bert-Jan H.; Agyemang, Charles J Hypertens

Objective: Hypertension prevalence is high among African migrants, but the determinants of hypertension in migrants in Europe in relation to the population in the country of origin still needs to be elucidated. Therefore, the aim of this study was to assess the determinants of hypertension in (...) -- ORIGINAL ARTICLES

1 April

J Hypertens http://journals.lww.com/jhypertension/

07:00
Initial combination therapy for hypertension in patients of African ancestry: a systematic review and meta-analysis - Brewster, Lizzy M.; Boermeester, Amber S.; Seedat, Yackoob K.; Van Montfrans, Gert A. J Hypertens

We systematically reviewed randomized controlled trials (RCTs) that consider the effect of initial dual antihypertensive combination treatment on blood pressure (BP), morbidity, or mortality in hypertensive African ancestry adults, using the methodology of the Cochrane Collaboration. Main (...) -- REVIEW
07:00
Effect of long-term antihypertensive therapy on myocardial strain: a meta-analysis - Tadic, Marijana; Gherbesi, Elisa; Sala, Carla; Carugo, Stefano; Cuspidi, Cesare J Hypertens

Aim: Evidence on the impact of blood pressure (BP)-lowering drugs on left ventricular (LV) mechanics in hypertension is still limited. We performed a meta-analysis of speckle-tracking echocardiographic studies in order to provide a new piece of information on this topic. Methods: The PubMed, (...) -- REVIEW
07:00
The counter-regulatory arm of the renin-angiotensin system and COVID-19: insights from Gitelman's and Bartter's syndromes - Stefanelli, Lucia Federica; Gobbi, Laura; Ravarotto, Verdiana; Bertoldi, Giovanni; Calò, Lorenzo A. J Hypertens

No abstract available -- EDITORIAL
07:00
Association of urinary angiotensinogen with renal arteriolar remodeling in chronic kidney disease - Kanamitsu, Takafumi; Kohagura, Kentaro; Zamami, Ryo; Nakamura, Takuto; Oshiro, Nanako; Miyagi, Tsuyoshi; Nakamura, Koshi; Ohya, Yusuke J Hypertens

Objective: Renin–angiotensin system (RAS) might be associated with arteriolar remodeling. The present study aimed to explore the hitherto unknown relationship between renal RAS and renal arteriolar remodeling and to elucidate whether altered renal RAS subsequently affects renal function in (...) -- ORIGINAL ARTICLES
07:00
Carotid–femoral pulse wave velocity acquisition methods and their associations with cardiovascular risk factors and subclinical biomarkers of vascular health - Aizawa, Kunihiko; Gates, Phillip E.; Mawson, David M.; Elyas, Salim; Casanova, Francesco; Gooding, Kim M.; Adingupu, Damilola D.; Strain, W David; Shore, Angela C. J Hypertens

Background: Different methods to measure carotid–femoral pulse wave velocity (CFPWV) may affect the measurements obtained and influence the association between CFPWV, cardiovascular risk factors and biomarkers of subclinical vascular health. The estimation of distance between the carotid and (...) -- ORIGINAL ARTICLES
07:00
Antecedent use of renin-angiotensin system inhibitors is associated with reduced mortality in elderly hypertensive Covid-19 patients - Gori, Mauro; Berzuini, Carlo; D’Elia, Emilia; Ghirardi, Arianna; Bernardinelli, Luisa; Gavazzi, Antonello; Balestrieri, Giulio; Giammarresi, Andrea; Trevisan, Roberto; Di Marco, Fabiano; Bellasi, Antonio; Amoroso, Mariangela; Raimondi, Federico; Novelli, Luca; Magro, Bianca; Mangia, Gianpaolo; Lorini, Ferdinando L.; Guagliumi, Giulio; Fagiuoli, Stefano; Parati, Gianfranco; Senni, Michele J Hypertens

Objectives: The effect of renin-angiotensin system inhibitors (RASIs) on mortality in patients with coronavirus disease (Covid-19) is debated. From a cohort of 1352 consecutive patients admitted with Covid-19 to Papa Giovanni XXIII Hospital in Bergamo, Italy, between February and April 2020, we (...) -- ORIGINAL ARTICLES
07:00
Rho kinase inhibition ameliorates vascular remodeling and blood pressure elevations in a rat model of apatinib-induced hypertension - Li, Caie; Ma, Liping; Wang, Qiongying; Shao, Xuejiao; Guo, Lu; Chen, Jianshu; Wang, Wenjuan; Yu, Jing J Hypertens

Objectives: Hypertension is one of the major adverse effects of tyrosine kinase inhibitors (TKIs) targeting vascular endothelial growth factors. However, the mechanism underlying TKIs-induced hypertension remains unclear. Here, we explored the role of the RhoA/Rho kinase (ROCK) signaling (...) -- ORIGINAL ARTICLES
07:00
Association between post-traumatic stress disorder and hypertension in Congolese exposed to violence: a case–control study - Bapolisi, Achille; Maurage, Pierre; Pappaccogli, Marco; Georges, Coralie M.G.; Petit, Géraldine; Balola, Mitterrand; Cikomola, Cirhuza; Bisimwa, Ghislain; Burnier, Michel; Persu, Alexandre; de Timary, Philippe J Hypertens

Background: Numerous risk factors have been involved in the pathogenesis of hypertension. The contribution of psychological factors, including post-traumatic stress disorder, remains largely underexplored, despite their potential role in hypertension. Objectives: We compared the prevalence of (...) -- ORIGINAL ARTICLES
07:00
Association between DBP and major adverse cardiovascular events in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention - Liu, Yuan-Hui; Dai, Yi-Ning; Wang, Li-Tao; Chen, Peng-Yuan; Zeng, Li-Huan; Zhang, Ye-Shen; Duan, Chong-Yang; Chen, Ji-Yan; Tan, Ning; He, Peng-Cheng J Hypertens

Background: In patients with stable coronary artery disease, low DBP is associated with an increased risk of myocardial infarction and cardiovascular death, but its association with clinical outcomes in patients with acute myocardial infarction undergoing percutaneous coronary intervention (...) -- ORIGINAL ARTICLES
07:00
Comparison of the mean of the first two blood pressure readings with the overall mean of three readings on a single occasion - Xu, Shao-Kun; Chen, Xin; Sheng, Chang-Sheng; Cheng, Yi-Bang; Wang, Hong-Yu; Yu, Wei; Li, Yan; Wang, Ji-Guang J Hypertens

Objective: Guidelines differed on the required number of blood pressure (BP) readings for accurate BP assessment. We, therefore, compared the mean of the first two BP readings with the overall mean of three readings in the diagnosis of hypertension. Methods: BP was measured three times (...) -- ORIGINAL ARTICLES
07:00
The association of uric acid with mortality modifies at old age: data from the uric acid right for heart health (URRAH) study - Ungar, Andrea; Rivasi, Giulia; Di Bari, Mauro; Virdis, Agostino; Casiglia, Edoardo; Masi, Stefano; Mengozzi, Alessandro; Barbagallo, Carlo M.; Bombelli, Michele; Bruno, Bernardino; Cicero, Arrigo F.G.; Cirillo, Massimo; Cirillo, Pietro; Desideri, Giovambattista; D’elia, Lanfranco; Ferri, Claudio; Galletti, Ferruccio; Gesualdo, Loreto; Giannattasio, Cristina; Iaccarino, Guido; Ciccarelli, Michele; Lippa, Luciano; Mallamaci, Francesca; Maloberti, Alessandro; Mazza, Alberto; Muiesan, Maria Lorenza; Nazzaro, Pietro; Palatini, Paolo; Parati, Gianfranco; Pontremoli, Roberto; Quarti-Trevano, (...) J Hypertens

Objectives: In older individuals, the role of serum uric acid (SUA) as risk factor for mortality is debated. This study investigated the association of SUA with all-cause and cardiovascular (CV) mortality in older adults participating in the large multicentre observational uric acid right for (...) -- ORIGINAL ARTICLES
07:00
Consequences of hyperandrogenemia during pregnancy in female offspring: attenuated response to angiotensin II - Shawky, Noha M.; Dalmasso, Carolina; Ojeda, Norma B.; Zuchowski, Yvonne; Stachenfeld, Nina; Alexander, Barbara T.; Reckelhoff, Jane F. J Hypertens

Background: Polycystic ovary syndrome (PCOS) is characterized by reproductive and metabolic dysfunction, and elevated blood pressure (BP). The cardiometabolic consequences of maternal hyperandrogenemia on offspring, either as adults or with aging, have not been well studied. We previously found (...) -- ORIGINAL ARTICLES
07:00
Prevalence and renal prognosis of left ventricular diastolic dysfunction in non-dialysis chronic kidney disease patients with preserved systolic function - Borrelli, Silvio; De Nicola, Luca; Garofalo, Carlo; Paoletti, Ernesto; Lucà, Sergio; Chiodini, Paolo; Lucà, Stefano; Peruzzu, Nicola; Netti, Antonella; Lembo, Eugenio; Stanzione, Giovanna; Conte, Giuseppe; Minutolo, Roberto J Hypertens

Background: Left ventricular (LV) diastolic dysfunction is common in non-dialysis chronic kidney disease (ND-CKD) patients; however, the prevalence estimated according to the new diagnostic criteria as well as the prognostic role of diastolic dysfunction on CKD progression remain unknown. (...) -- ORIGINAL ARTICLES
07:00
Retinal microvascular abnormalities and risks of incident stroke and its subtypes: The Circulatory Risk in Communities Study - Li, Jiaqi; Imano, Hironori; Kitamura, Akihiko; Kiyama, Masahiko; Yamagishi, Kazumasa; Tanaka, Mari; Ohira, Tetsuya; Sankai, Tomoko; Umesawa, Mitsumasa; Muraki, Isao; Hayama-Terada, Mina; Okada, Takeo; Cui, Renzhe; Tanigawa, Takeshi; Iso, Hiroyasu J Hypertens

Background: This study aimed to investigate the association between retinal microvascular abnormalities and the risk of incident stroke and its subtypes in the general Japanese population. Methods: A total of 12 965 residents aged 40–74 years without a history of stroke and/or coronary heart (...) -- ORIGINAL ARTICLES
07:00
BMI and blood pressure control among United States adults with hypertension - Foti, Kathryn; Hardy, Shakia T.; Chang, Alex R.; Selvin, Elizabeth; Coresh, Josef; Muntner, Paul J Hypertens

Objectives: Less than half of United States adults with hypertension have controlled blood pressure (BP). Higher BMI is associated with an increased risk for hypertension but the association between BMI and BP control is not well characterized. We examined hypertension awareness, (...) -- ORIGINAL ARTICLES
07:00
Blood pressure undulation of peripheral thrombolysis period in acute ischemic stroke is associated with prognosis - He, Mingli; Wang, Hongrui; Tang, Yi; Wang, Jin’e; Cui, Bing; Xu, Bingchao; Sun, Yongan; Zhang, Guanghui; He, Xiaobing; Niu, Xiaoqin; Wang, Bei; Xu, Bei; Li, Zaipo; Zhang, Yu; Wang, Yibo J Hypertens

Background: Evidence suggests that patients with higher blood pressure variability (BPV) have a higher risk for stroke but the relationship between BPV and stroke outcomes is unknown in those who underwent intravenous thrombolysis (IVT) for acute ischemic stroke (AIS). The objective of this (...) -- ORIGINAL ARTICLES
07:00
White-coat hypertension/effect is associated with higher arterial stiffness and stroke events - Saunders, Alec; Nuredini, Gani N.; Kirkham, Frances A.; Drazich, Erin; Bunting, Eva; Rankin, Philip; Ali, Khalid; Okorie, Michael; Rajkumar, Chakravarthi J Hypertens

Objectives: The risk profile of white-coat hypertension/effect (WCH/E) remains unclear. This study aimed to investigate the relationship between WCH/E, markers of cardiovascular risk and cerebrovascular events. Methods: This is a sub-group analysis of The Arterial Stiffness In lacunar Stroke (...) -- ORIGINAL ARTICLES
07:00
Time series proteome profile analysis reveals a protective role of citrate synthase in angiotensin II-induced atrial fibrillation - Teng, Fei; Han, Xiao; Yu, Peng; Li, Pang-Bo; Li, Hui-Hua; Zhang, Yun-Long J Hypertens

Background: Angiotensin (Ang) II and elevated blood pressure are considered to be the main risk factors for atrial fibrillation. However, the proteome profiles and key mediators/signaling pathways involved in the development of Ang II-induced atrial fibrillation remain unclear. Methods: Male (...) -- ORIGINAL ARTICLES
07:00
Hypertension and contraceptive use among women of child-bearing age in the United States from 2001 to 2018 - Kovell, Lara C.; Meyerovitz, Claire V.; Skaritanov, Ekaterina; Ayturk, Didem; Person, Sharina D.; Kumaraswami, Tara; Juraschek, Stephen P.; Moore Simas, Tiffany A. J Hypertens

Background: Hypertension (HTN) in pregnancy is a leading cause of maternal mortality in the United States. Contraception is widely used, and estrogen-based combined hormonal forms are known to increase blood pressure (BP). With nearly half of pregnancies unplanned and many antihypertensive (...) -- ORIGINAL ARTICLES
07:00
Restricted dietary pattern may contribute to lowering blood pressure in adolescents with obesity: Study of Cardiovascular Risk in Adolescents - Neves, Morgana E.A.; Souza, Marielly R.; Gorgulho, Bartira M.; Pereira, Rosangela A.; Cunha, Diana B.; Souza, Amanda M.; Muraro, Ana Paula; Ferreira, Márcia G.; Rodrigues, Paulo R.M. J Hypertens

Objective: Dieting is one of the main target factors for interventions that seek to control and prevent rising blood pressure. This study identified dietary patterns and analyzed their association with adolescents’ blood pressure. Methods: This is a cross-sectional study with a probabilistic and (...) -- ORIGINAL ARTICLES
07:00
Stage 1 hypertension and risk of cardiovascular disease mortality in United States adults with or without diabetes - Wang, Yutang J Hypertens

Objective: This study aimed to investigate the association of S1 hypertension, classified according to the 2017 American College of Cardiology/American Heart Association blood pressure (BP) guideline, with cardiovascular disease (CVD) mortality in adults with or without diabetes from the (...) -- ORIGINAL ARTICLES
07:00
Differences in estimated glomerular filtration rate are associated with different patterns of 24-h ambulatory blood pressure in the general population - Yoon, Sang Gon; Lee, Seung Ku; Kim, Seong Hwan; Shin, Chol; Han, Sang Youb J Hypertens

Background: Alterations of the circadian blood pressure rhythm are associated with cardiovascular and chronic kidney diseases. We investigated the relationship between 24-h ambulatory blood pressure monitoring (ABPM) patterns and eGFR differences in participants without chronic kidney disease. (...) -- ORIGINAL ARTICLES
07:00
Hypertension-mediated organ damage in masked hypertension - Hinderliter, Alan L.; Lin, Feng-Chang; Viera, Laura A.; Olsson, Emily; Klein, J. Larry; Viera, Anthony J. J Hypertens

Objectives: Masked hypertension – a blood pressure (BP) phenotype characterized by a clinic BP in the normal range but elevated BP outside the office – is associated with early hypertension-mediated organ damage. This study examined early target organ manifestations of masked hypertension (...) -- ORIGINAL ARTICLES
07:00
Dominant role of CACNA1D exon mutations for blood pressure regulation - Wang, Huan; Zhu, Jing-Kang; Cheng, Lan; Mao, Gaowei; Chen, Hong; Wu, Xiaoying; Hong, Huiwu; Wang, Canwang; Lin, Pengcheng; Chen, Jie; Maboh, Rene Nfornah; Chen, Hui J Hypertens

Background: CACNA1D gene, which encodes the ?1 subunit of the Cav1.3 L-type calcium channel effectively regulates intracellular Ca2+ stability. In recent years, clinical studies have shown that the CACNA1D polymorphisms were associated with hypertension. Objective: The purpose of this study was (...) -- ORIGINAL ARTICLES
07:00
Reply to ‘Why we do not need a single independent international hypertension clinical practice guideline’ - Ben-Eltriki, Mohamed; Cassels, Alan; Erviti, Juan; Wright, James M. J Hypertens

No abstract available -- CORRESPONDENCE
07:00
Plasma PAPP-A2 and genetic variations with hypertension - Sookaromdee, Pathum; Wiwanitkit, Viroj J Hypertens

No abstract available -- CORRESPONDENCE
07:00
Reply to ‘Plasma PAPP-A2 and genetic variations with hypertension’ - Wang, Yang; Jia, Hao; Mu, Jian-Jun J Hypertens

No abstract available -- CORRESPONDENCE

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