14 March

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 01:00
  JAMA J Am Med Assoc (JAMA)
• 01:00
  Negative Trial Challenges Paradigms and Guidelines J Am Med Assoc (JAMA)
  In this issue of JAMA, Borlaug and colleagues report the results of a important clinical trial, which are likely to alter paradigms and clinical guidelines for heart failure with preserved ejection fraction (HFpEF). The prevalence of this syndrome has progressively increased, and HFpEF has (...)
• 01:00
  Atrial Pacing for Chronotropic Incompetence in HFpEF J Am Med Assoc (JAMA)
  This randomized crossover trial assessed if implanting and programming a pacemaker for rate-adaptive atrial pacing improved exercise performance in patients with heart failure with preserved ejection fraction and chronotropic incompetence at a single US tertiary referral (...)
• 01:00
  Physicians Are More Burned Out Than Ever—Here’s What Can Be Done About It J Am Med Assoc (JAMA)
  This Medical News article discusses US initiatives to improve health care worker well-being as burnout and intent to leave to medicine reach record levels.
• 01:00
  Cradling Hope J Am Med Assoc (JAMA)
  In this narrative medicine essay, a physician recounts her family’s experience with critical illness and death and how she came to appreciate both the health care team’s perspective and the family’s perspective regarding when to have hope and when to let (...)
• 01:00
  Study: No New SARS-CoV-2 Variants in Recent Outbreak in China J Am Med Assoc (JAMA)
  After relaxing its “zero-COVID policy” in early December 2022, China’s SARS-CoV-2 infections surged, stoking concerns that new variants might appear. But none emerged in a genomic analysis of 413 COVID-19 cases collected in Beijing between November 14 and December 20, 2022. Two Omicron (...)
• 01:00
  Teens Report Record Levels of Violence, Mental Health Challenges J Am Med Assoc (JAMA)
  Adolescent mental health continued to worsen through 2021, based on survey responses from 17 232 high school students. According to the report from the US Centers for Disease Control and Prevention, teen girls scored worse than boys on almost all measures collected, with nearly twice the number (...)
• 01:00
  Federal Officials Issue Initial Guidance to Rein in Drug Spending J Am Med Assoc (JAMA)
  The US Department of Health and Human Services released a preliminary plan for decreasing drug prices as part of the Inflation Reduction Act (IRA), which President Joe Biden signed into law last August. Under the Medicare Prescription Drug Inflation Rebate Program, companies will be required to (...)
• 01:00
  New Report Estimates Disease Burden Among Displaced Ukrainians J Am Med Assoc (JAMA)
  Russia’s invasion of Ukraine has led to the displacement of about 12.3 million Ukrainians—more than 25% of the country’s population. About half of those displaced left for other countries; the remainder moved within Ukraine.
• 01:00
  Single Dose of Antibiotic Reduced Maternal Sepsis J Am Med Assoc (JAMA)
  A 2-g oral dose of azithromycin administered during labor for women planning a vaginal birth reduced the risk of maternal sepsis or death by 33%, with an absolute risk reduction of 0.8%, according to results from a randomized clinical trial. Reduced sepsis in the group that received the (...)
• 01:00
  Seizure Drug Increased Heart Donor Storage Time, Improved Function J Am Med Assoc (JAMA)
  The antiseizure drug valproic acid might improve heart function in transplant recipients and expand the pool of donor hearts by increasing their storage time, a preclinical study published in Science Translational Medicine suggests.
• 01:00
  Oral Health Worsened, Visits Decreased in Medicare Beneficiaries J Am Med Assoc (JAMA)
  When US adults reached age 65 years and became eligible for Medicare, their visits for restorative dental procedures such as fillings or crowns fell by 8.7%, according to survey responses from 97 108 participants aged 50 to 85 years. Moreover, the loss of all teeth, or complete edentulism, (...)
• 01:00
  MicroRNAs Expressed in Pancreatic Islets Linked With Type 2 Diabetes J Am Med Assoc (JAMA)
  Genetic sequencing data from 63 participants linked 14 microRNAs (miRNAs) expressed in human pancreatic islet cells, which produce hormones that regulate blood glucose, with type 2 diabetes, according to results reported in Proceedings of the National Academy of Sciences. The study also linked (...)
• 01:00
  COVID-19 Vaccination During Pregnancy Protected Infants J Am Med Assoc (JAMA)
  Two doses of COVID-19 vaccine administered to mothers during pregnancy were 95% effective against infection with the SARS-CoV-2 Delta variant and 97% effective against related hospitalizations among infants younger than 6 months, according to a study of 8809 infants in The BMJ. Protection was (...)
• 01:00
  As Superbugs Flourish, Bacteriophage Therapy Recaptures Researchers’ Interest J Am Med Assoc (JAMA)
  This Medical News article discusses the resurgence of phage therapy research for antibiotic-resistant infections.
• 01:00
  Stool-Based Screening Tests for Colorectal Cancer J Am Med Assoc (JAMA)
  A 56-year-old man with no significant medical history has declined screening colonoscopy at previous physician visits but wants to undergo a less invasive test because his father died of colorectal cancer at age 80. What would you do (...)
• 01:00
  Patient Information: Strabismus J Am Med Assoc (JAMA)
  This JAMA Patient Page describes the eye condition of strabismus, its signs and symptoms, causes, diagnosis, and treatment.
• 01:00
  Relaunching JAMA Express J Am Med Assoc (JAMA)
  Today we relaunch JAMA Express, a pathway in which manuscripts receive expedited review and processing with the goal of online first publication of accepted work within 4 weeks of submission. The JAMA Express pathway includes the standard rigorous editorial and peer review, editing, and (...)
• 01:00
  Streamlining Interstate Access to Gender-Affirming Surgeries J Am Med Assoc (JAMA)
  This Viewpoint explains the obstacles faced by individuals seeking gender-affirming care and summarizes needed changes to improve quality of care and access to care.
• 01:00
  Antidiscrimination Laws as Essential Tools for Achieving LGBTQ+ Health Equity J Am Med Assoc (JAMA)
  This Viewpoint discusses a pending US Supreme Court case to determine the extent to which people who identify as LGBTQ+ are protected under state antidiscrimination laws in the commercial marketplace.
• 01:00
  Appropriateness of Cardiovascular Disease Prevention Recommendations From Online Chat-Based AI Model J Am Med Assoc (JAMA)
  This study examines the appropriateness of artificial intelligence model responses to fundamental cardiovascular disease prevention questions.
• 01:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 01:00
  The Therapy of Certain Functional Nervous Disturbances J Am Med Assoc (JAMA)
  The treatment of headache or migraine, like that of fatigue, mental lethargy, and the whole complex of neurasthenia, is admittedly unsatisfactory. The reason for this lies primarily in our ignorance of the genesis of these clinical disturbances. There seems to be a crying need of immediate (...)
• 01:00
  Consistency of Physician Data Across Health Insurer Directories J Am Med Assoc (JAMA)
  This study assesses the consistency of information across publicly available physician directories from 5 large national health insurers.
• 01:00
  Extracorporeal Membrane Oxygenation and New Mental Health Diagnoses in Adult Survivors of Critical Illness J Am Med Assoc (JAMA)
  To the Editor A recent study found that extracorporeal membrane oxygenation (ECMO) was significantly associated with a modestly increased risk of new mental health diagnoses or social problems in adult survivors of critical illness in Canada. Although Cox regression analyses were performed to (...)
• 01:00
  Spinal Cord Burst vs Placebo Stimulation for Chronic Radicular Pain After Lumbar Spine Surgery J Am Med Assoc (JAMA)
  To the Editor In a recent randomized clinical trial that included patients with chronic radicular pain after spine surgery, Dr Hara and colleagues found no significant difference in back pain–related disability with burst spinal cord stimulation vs placebo. We commend the authors for their (...)
• 01:00
  Spinal Cord Burst vs Placebo Stimulation for Chronic Radicular Pain After Lumbar Spine Surgery J Am Med Assoc (JAMA)
  To the Editor We believe there are several methodological problems that limit interpretation of the findings of the crossover randomized clinical trial by Dr Hara and colleagues. A fundamental flaw is that patient selection was based on a minimal 2-point reduction in leg pain using a (...)
• 01:00
  Spinal Cord Burst vs Placebo Stimulation for Chronic Radicular Pain After Lumbar Spine Surgery J Am Med Assoc (JAMA)
  To the Editor We believe that there are multiple issues that limit the generalizability of the recent randomized clinical trial of spinal cord burst stimulation vs placebo stimulation in patients with chronic radicular pain after lumbar spine (...)
• 01:00
  Spinal Cord Burst vs Placebo Stimulation for Chronic Radicular Pain After Lumbar Spine Surgery J Am Med Assoc (JAMA)
  To the Editor We have several concerns regarding the recent randomized clinical trial about the role of burst stimulation in patients with chronic pain after back surgery.
• 01:00
  Spinal Cord Burst vs Placebo Stimulation for Chronic Radicular Pain After Lumbar Spine Surgery J Am Med Assoc (JAMA)
  To the Editor As leaders of the American Society of Anesthesiologists, the American Association of Neurological Surgeons, the American Academy of Pain Medicine, the American Society of Pain and Neuroscience, the Congress of Neurological Surgeons, the International Neuromodulation Society, and (...)
• 01:00
  Extracorporeal Membrane Oxygenation and New Mental Health Diagnoses in Adult Survivors of Critical Illness—Reply J Am Med Assoc (JAMA)
  In Reply Our study demonstrated a modest association between survivorship after ECMO and new mental health diagnoses. In their Letter, Drs Li and Li hypothesize that this association may have been mediated by differences in sedation among patients exposed to (...)
• 01:00
  Spinal Cord Burst vs Placebo Stimulation for Chronic Radicular Pain After Lumbar Spine Surgery—Reply J Am Med Assoc (JAMA)
  In Reply In our quadruple-blinded, crossover, randomized clinical trial of 50 patients with chronic radicular pain after spine surgery, spinal cord burst stimulation resulted in no significant differences in core outcome measures, including functional disability measured by the Oswestry (...)
• 01:00
  California’s State Insurance Gender Nondiscrimination Act and Utilization of Gender-Affirming Surgery J Am Med Assoc (JAMA)
  This population epidemiology study assesses the association of California’s 2013 implementation of the Insurance Gender Nondiscrimination Act and utilization of gender-affirming surgery among California residents, compared with residents of the control states of Washington and (...)
• 01:00
  Medicare Advantage Enrollment by Beneficiaries With End-Stage Renal Disease J Am Med Assoc (JAMA)
  This cross-sectional study uses data from Medicare beneficiaries with ESRD (kidney transplant recipients and those undergoing dialysis) to examine changes in Medicare Advantage enrollment after enactment of the 21st Century Cures Act overall, by race and ethnicity, and by dual-eligible (...)
• 01:00
  Wonder J Am Med Assoc (JAMA)
  I wonder if the dead remember us, like we remember them. Scared of ghosts as a child, I see how
• 01:00
  “I Wonder”—The Role of Poetry in Palliative Care J Am Med Assoc (JAMA)
  A vital place for poetry in the work of clinicians is in palliative care as patients, families, and end-of-life professionals confront the limits of what allopathic treatments offer. In a riff on an interview technique taught to palliative care clinicians to help elicit patients’ and loved ones’ (...)
• 01:00
  Heart Failure With Preserved Ejection Fraction J Am Med Assoc (JAMA)
  This review discusses current evidence regarding the epidemiology, pathophysiology, clinical presentation, diagnosis, and management of heart failure with preserved ejection fraction.

7 March

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 01:00
  NIH Considers Lessons Learned During COVID-19 Pandemic J Am Med Assoc (JAMA)
  A decades-long investment in basic science research, focus on diversity in clinical trials, and coordinated efforts to repurpose therapeutics and develop diagnostics were among the factors that contributed to the US National Institutes of Health–led response to COVID-19, according to a report (...)
• 01:00
  Most COVID-19 Deaths Worldwide Were Among Older People J Am Med Assoc (JAMA)
  More than 80% of the global COVID-19–related deaths between 2020 and 2021 occurred among people aged 60 years or older, according to data published by the World Health Organization (WHO) in Morbidity and Mortality Weekly Report.
• 01:00
  More Primary Care Visits Address Mental Health J Am Med Assoc (JAMA)
  Between 2006 and 2018, the number of visits during which primary care physicians managed mental health concerns increased by 50%, from about 11% of visits to about 16%, according to an analysis of 109 989 visits published in Health Affairs. Visits that had focused on depression and other (...)
• 01:00
  FDA Approves First Oral Treatment for Kidney Disease–Induced Anemia J Am Med Assoc (JAMA)
  The US Food and Drug Administration (FDA) has approved the first oral treatment for anemia caused by chronic kidney disease.
• 01:00
  CMS Rule Cracks Down on Medicare Advantage Overpayments J Am Med Assoc (JAMA)
  Under a new rule, US Centers for Medicare and Medicaid Services (CMS) anticipates recovering billions of dollars from Medicare Advantage insurers, which cover around 30 million eligible people.
• 01:00
  Long COVID Linked With Unemployment in New Analysis J Am Med Assoc (JAMA)
  This Medical News article discusses new research on the association between long COVID and employment status.
• 01:00
  Questions Remain About What Should Go Into Annual COVID-19 Vaccines J Am Med Assoc (JAMA)
  This Medical News story examines the US Food and Drug Administration’s proposed plans for an annual COVID-19 vaccination.
• 01:00
  Finding Answers J Am Med Assoc (JAMA)
  In this narrative medicine essay, a pharmacoepidemiologist worries that her brother’s lifelong neurological challenges may have been caused by a heritable genetic variant and that she possibly passed it to her young son, who looks uncannily like his (...)
• 01:00
  Pregnancy After Bariatric Surgery J Am Med Assoc (JAMA)
  This JAMA Insights Clinical Update discusses general adaptations for pregnancy after bariatric surgery, including recommendations regarding nutrition, maternal health, and fetal and neonatal risks.
• 01:00
  Patient Information: Vibrio vulnificus J Am Med Assoc (JAMA)
  This JAMA Patient Page describes Vibrio vulnificus infection, its signs and symptoms, diagnosis, treatment, and prevention strategies.
• 01:00
  Implementing the White House’s Strategic Plan to Save Lives Amid the Opioid Crisis J Am Med Assoc (JAMA)
  This Viewpoint discusses the goals of the inaugural National Drug Control Strategy, which as the ambitious agenda of emphasizing harm reduction practices, medications for treating opioid use disorder, and criminal justice reform, as well as supporting long-term recovery and interrupting illicit (...)
• 01:00
  Agenda for Substance Use Prevention and Treatment in the US J Am Med Assoc (JAMA)
  In this Viewpoint, officials from the White House Office of National Drug Control Policy describe 3 actions that health care personnel can take to expand prevention and treatment of substance misuse and overdose.
• 01:00
  Association of Preapproval Confirmatory Trial Initiation and Conversion to Traditional Approval or Withdrawal in the FDA Approval Pathway J Am Med Assoc (JAMA)
  This study examines the Food and Drug Administration’s accelerated approval pathway and whether preapproval initiation was associated with faster conversion to traditional approval or withdrawal for drugs with nononcology indications.
• 01:00
  Still Looking for a Simple, Effective Prevention Measure for Neonatal Sepsis in High-Mortality Settings J Am Med Assoc (JAMA)
  The “Decade of Vaccines” contributed to notable global declines in mortality among children younger than 5 years, but mortality in the neonatal period remains a stubborn problem. Most neonatal deaths occur in the first week of life. The causes of such deaths are difficult to characterize. (...)
• 01:00
  Reducing Acetaminophen Toxicity J Am Med Assoc (JAMA)
  Acetaminophen (paracetamol) is the most widely used pain reliever globally. It was approved in the US in 1950 as a prescription drug and then for over-the-counter (OTC) use in 1955. Currently, more than 52 million persons in the US consume acetaminophen on a weekly basis, although many of them (...)
• 01:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 01:00
  The Status of Epidemic Encephalitis as an Independent Disease J Am Med Assoc (JAMA)
  From the spring of 1920 until recently, there have been comparatively few new cases of epidemic (lethargic) encephalitis in North America, and interest in it has been kept up mainly by the surprising array of its somatic and psychic sequels. Within the last few weeks, however, reports have come (...)
• 01:00
  Health Equity Measures and Hospital Rankings J Am Med Assoc (JAMA)
  To the Editor In a recent Viewpoint, authors from US News & World Report described several health equity measures to be used to evaluate hospitals’ performance on 3 dimensions: access, outcome, and social determinants of health. While we applaud the effort to promote health equity and (...)
• 01:00
  Unintended Pregnancy and Maternal and Infant Health Outcomes J Am Med Assoc (JAMA)
  To the Editor A recent systematic review and meta-analysis concluded that unintended pregnancy was significantly associated with higher odds of depression during pregnancy and postpartum, and increased maternal experience of interpersonal violence, preterm birth, and infant low birth weight. (...)
• 01:00
  Lower vs Higher Oxygen Saturation Targets and Survival to Hospital Discharge Among Patients Resuscitated After Out-of-Hospital Cardiac Arrest J Am Med Assoc (JAMA)
  To the Editor A recent study compared the effect of 2 oxygen saturation targets on survival after out-of-hospital cardiac arrest. The authors have focused on an important area of postresuscitation care, because hyperoxia (defined as Pao2 >300 mm Hg) has shown to be associated with worse (...)
• 01:00
  Health Equity Measures and Hospital Rankings—Reply J Am Med Assoc (JAMA)
  In Reply In response to our recent Viewpoint about hospital rankings and health equity, Dr Bai and colleagues note that certain hospitals may attract patients from a broader geographic base outside of the hospital service area for various reasons, including providing specialized care. To (...)
• 01:00
  Unintended Pregnancy and Maternal and Infant Health Outcomes—Reply J Am Med Assoc (JAMA)
  In Reply We agree with Dr Luo and colleagues that the nonrandomized studies of unintended pregnancy and health outcomes included in our systematic review and meta-analysis are subject to bias and methodological limitations. However, this research question will never be answered with randomized (...)
• 01:00
  Lower vs Higher Oxygen Saturation Targets and Survival to Hospital Discharge Among Patients Resuscitated After Out-of-Hospital Cardiac Arrest—Reply J Am Med Assoc (JAMA)
  In Reply Regarding our recent study, Drs Wetsch and Böttiger are concerned that a target oxygen saturation of 90% to 94% in the EXACT trial should be considered hypoxia. This target oxygen saturation was justified by a meta-analysis of previous phase 2 trials testing a lower oxygen target in (...)
• 01:00
  Effect of Intrapartum Azithromycin vs Placebo on Neonatal Sepsis and Death J Am Med Assoc (JAMA)
  This randomized trial compares the efficacy of intrapartum azithromycin vs placebo to reduce neonatal sepsis or mortality, as well as neonatal and maternal infections, among birthing parents and their infants in West Africa.
• 01:00
  Limiting Acetaminophen in Prescription Combination Opioid Products J Am Med Assoc (JAMA)
  This interrupted time-series analysis uses data from the National Inpatient Sample and the Acute Liver Failure Study Group to assess the odds of hospitalization and the proportion of acute liver failure cases with acetaminophen and opioid toxicity prior to and after the US Food and Drug (...)
• 01:00
  Induction Therapy With Olamkicept vs Placebo for Active Ulcerative Colitis J Am Med Assoc (JAMA)
  This randomized clinical trial compares clinical response at 12 weeks with olamkicept vs placebo in treating adult patients with active ulcerative colitis.
• 01:00
  DNA Sequencing to Detect Residual Disease for Acute Myeloid Leukemia J Am Med Assoc (JAMA)
  In this observational study, targeted deep DNA sequencing was performed to test the hypothesis that detection of specific residual AML-associated variants in the blood of patients in first remission prior to allogeneic hematopoietic cell transplant would be associated with higher rates of (...)
• 01:00
  After a Night of Odd Angles J Am Med Assoc (JAMA)
  The ends of me tingle, fingertips and toes caught alive, as when we swam in the phosphorescence, peeled off our waitressing uniforms after our shift, slipped into the Atlantic, frigid and gentle, moved in circles to create light.
• 01:00
  JAMA J Am Med Assoc (JAMA)
• 01:00
  Management of Thoracic Aortic Dissection J Am Med Assoc (JAMA)
  This JAMA Clinical Guidelines Synopsis summarizes the 2021 guidelines from the American Association for Thoracic Surgery and the Society of Thoracic Surgeons on management of type A and type B thoracic aortic dissection.
• 01:00
  States’ Methods for Capturing and Reporting Local Responses to Suspected Nonfatal Drug Overdoses J Am Med Assoc (JAMA)
  This study examines the available data used to surveil state-level drug overdoses and characterizes them based on their timeliness, drug involvement, and specification of nonfatal outcomes.
• 01:00
  Marburg Vaccine Safe, Immunogenic in Phase 1 Trial J Am Med Assoc (JAMA)
  An investigational Marburg virus vaccine was well-tolerated and generated an enduring immune response after a single dose, according to the results of a phase 1 clinical trial.
• 01:00
  Meta-analysis: Vitamin D Therapy Reduced Type 2 Diabetes J Am Med Assoc (JAMA)
  People with prediabetes who received vitamin D therapy had a 15% lower risk of developing type 2 diabetes in adjusted analyses, with an absolute risk reduction of 3.3% over 3 years, according to a meta-analysis of 3 randomized placebo-controlled trials involving 4190 (...)
• 01:00
  Financial Coaching for Parents Increases Visits to Pediatrician J Am Med Assoc (JAMA)
  In a randomized trial, financial coaching for parents with low incomes improved attendance at pediatrician visits, researchers reported in Pediatrics. The infants whose parents received the intervention were also more likely to be up to date on (...)
• 01:00
  WHO Revises List of Stockpiled Drugs for Nuclear Emergencies J Am Med Assoc (JAMA)
  The World Health Organization (WHO) has released a document outlining the medications countries should have stored in case of a radiation or nuclear emergency, updating its 2007 recommendations.

28 February

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 01:00
  Incorrect Data in Table J Am Med Assoc (JAMA)
  In the Original Investigation titled “Effect of an Intensive Nurse Home Visiting Program on Adverse Birth Outcomes in a Medicaid-Eligible Population: A Randomized Clinical Trial” published in the July 5, 2022, issue of JAMA, incorrect percentages appeared in a table. In the last section of Table (...)
• 01:00
  Last Name Misspelled J Am Med Assoc (JAMA)
  In the Original Investigation titled “Effect of Regular, Low-Dose, Extended-release Morphine on Chronic Breathlessness in Chronic Obstructive Pulmonary Disease: The BEAMS Randomized Clinical Trial,” published in the November 22/29, 2022, issue of JAMA, a last name was misspelled in the list of (...)
• 01:00
  Updated Disclosures J Am Med Assoc (JAMA)
  An author of 2 Letters to the Editor published in JAMA in 2016 has provided updated conflict of interest disclosures. The updated disclosures for Dr Ralph Snyderman include serving on the boards of CareDx, Nodality, Press Ganey, Crescendo Biosciences, Targacept Inc, Trevena Inc, Purdue Pharma (...)
• 01:00
  Payment, Priorities, and Primary Care J Am Med Assoc (JAMA)
  If payment reflects priorities, there can be little doubt that the US dramatically undervalues primary care. Primary care is widely recognized as the foundation of an effective health care system, and evidence of its benefits is both enduring and robust: greater use of primary care has long (...)
• 01:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 01:00
  The Resourceful General Practitioner of Modern Medicine J Am Med Assoc (JAMA)
  Frank Billings, M.D., Chicago
• 01:00
  Cefepime/Enmetazobactam vs Piperacillin/Tazobactam and Complicated Urinary Tract Infection or Acute Pyelonephritis J Am Med Assoc (JAMA)
  To the Editor A recent trial comparing the effect of cefepime/enmetazobactam vs piperacillin/tazobactam on complicated urinary tract infection or acute pyelonephritis found that patients receiving cefepime/enmetazobactam had a better primary outcome. We have some concerns about this (...)
• 01:00
  Hydroxychloroquine Dose and Risk of Systemic Lupus Erythematosus Flares J Am Med Assoc (JAMA)
  To the Editor A recent study found that hydroxychloroquine dosing of 5 mg/kg per day or less was associated with a higher risk of lupus flares in patients with systemic lupus erythematosus. Although this study highlights the importance of tailoring the optimal dose of hydroxychloroquine in (...)
• 01:00
  Updated Conflict of Interest Disclosures J Am Med Assoc (JAMA)
  To the Editor I write to provide additional information regarding my conflict of interest disclosures in the Letters to the Editor published in JAMA on February 9, 2016, and November 8, 2016. In listing potential conflicts of interest, I disclosed relationships with companies I judged were (...)
• 01:00
  Cefepime/Enmetazobactam vs Piperacillin/Tazobactam and Complicated Urinary Tract Infection or Acute Pyelonephritis—Reply J Am Med Assoc (JAMA)
  In Reply In response to the insightful questions by Dr Hsu and colleagues, the ALLIUM phase 3 study was completed prior to the change in the CLSI piperacillin/tazobactam breakpoints in 2022 and the EUCAST breakpoints in 2021. However, a post hoc outcomes analysis was performed on the primary (...)
• 01:00
  Hydroxychloroquine Dose and Risk of Systemic Lupus Erythematosus Flares—Reply J Am Med Assoc (JAMA)
  In Reply The primary objective of our study was to evaluate the efficacy of hydroxychloroquine dosing on the outcome of overall lupus flares. Our study population included 342 patients from our academic medical center’s lupus cohort, of which 168 had at least 1 lupus flare and were otherwise (...)
• 01:00
  Endovascular Ultrasound Renal Denervation to Treat Hypertension J Am Med Assoc (JAMA)
  This sham-controlled, randomized clinical trial compares the efficacy and safety of ultrasound renal denervation vs a sham procedure without the confounding influence of antihypertensive medications in adults with hypertension.
• 01:00
  Payment Policy Changes and Medicare Payment to Physicians J Am Med Assoc (JAMA)
  This retrospective observational study compares simulated changes in Medicare evaluation and management (E/M) payment policy with observed changes in total Medicare payments to US office-based physicians and E/M coding intensity, before (July-December 2020) and after (July-December 2021) the (...)
• 01:00
  Patient Information: Borderline Personality Disorder J Am Med Assoc (JAMA)
  This JAMA Patient Page describes borderline personality disorder, its signs and symptoms, possible causes, diagnosis, and treatment options.
• 01:00
  An Education J Am Med Assoc (JAMA)
  At this point, I know too much and not enough. My frontal cortex
• 01:00
  Facts, Truths, and Poetry in Medical Education J Am Med Assoc (JAMA)
  “An Education” grapples with a central paradox of medical training: how to reconcile advancing scientific understanding of the human body with the vast mysteries of human suffering. “I know too much/and not enough” declares this tension at the poem’s outset with a formal disquiet as the thought (...)
• 01:00
  Review of Borderline Personality Disorder J Am Med Assoc (JAMA)
  This review summarizes current evidence regarding the epidemiology, pathophysiology, diagnosis, and treatment of borderline personality disorder in adults.
• 01:00
  JAMA J Am Med Assoc (JAMA)
• 01:00
  Effect of Argatroban Plus Alteplase vs Alteplase on Neurologic Function After Acute Ischemic Stroke J Am Med Assoc (JAMA)
  This randomized clinical trial examines the efficacy of argatroban plus altepase for acute ischemic stroke within 4.5 hours from onset.
• 01:00
  Healthful Lifestyle May Slow Memory Loss, Even for APOE Gene Carriers J Am Med Assoc (JAMA)
  A healthful lifestyle—particularly a balanced diet—may be tied to slower declines in memory, based on a 10-year study that followed up more than 29 000 people in China with normal cognition at baseline. The link held even for participants with the apolipoprotein E (APOE) gene, which increases the (...)
• 01:00
  Updated COVID-19 Guidance for People Who Are Immunocompromised J Am Med Assoc (JAMA)
  In late January, the US Food and Drug Administration announced that Evusheld (the combined monoclonal antibodies tixagevimab and cilgavimab) is not currently authorized for emergency use because it’s likely ineffective against more than 90% of SARS-CoV-2 variants now circulating in the US. (...)
• 01:00
  Trouble Paying Medical Bills Trends Down in US J Am Med Assoc (JAMA)
  A 2021 survey of more than 37 000 people in the US found that 10.8% live in families that had trouble paying medical bills in the last 12 months. That number was down from 14% in 2019, according to the most recent National Health Statistics Report. Nationally, that translates to 10.5 million (...)
• 01:00
  Public Health Workers Report Threats, Harassment During Pandemic J Am Med Assoc (JAMA)
  One-third of US public health workers experienced stigma, threats, harassment, and other negative treatment during the COVID-19 pandemic, based on responses from more than 26 000 workers surveyed in the spring of 2021.
• 01:00
  Paxlovid Alternative Is Similarly Effective J Am Med Assoc (JAMA)
  Patients with mild to moderate COVID-19 who were treated for 5 days with VV116, an investigational oral antiviral drug that is active against SARS-CoV-2, recovered as quickly from infection as did those treated with nirmatrelvir-ritonavir (Paxlovid), according to the results of a randomized (...)
• 01:00
  FDA Proposes Individual Risk Assessment for Blood Donation J Am Med Assoc (JAMA)
  The US Food and Drug Administration (FDA) has announced proposed changes in its recommendations governing blood donor eligibility to reduce the risk of transfusion-transmitted HIV. The proposed guidance assesses risk using gender-inclusive, individual questionnaires rather than using broad (...)
• 01:00
  Even Mild Concussions Tied to Worse Cognition Later in Life J Am Med Assoc (JAMA)
  Experiencing 3 or more mild traumatic brain injuries (TBIs) is linked with poorer cognitive activity decades later, according to an analysis of data from nearly 16 000 older adults. Attention and executive function appear to be more affected than processing speed or working memory, the study (...)
• 01:00
  How Alcohol Flushing Gene Variant May Raise Heart Disease Risk J Am Med Assoc (JAMA)
  Around 8% of people have an aldehyde dehydrogenase 2 variant called ALDH2*2 that can cause facial flushing after drinking alcohol and has been tied to higher risk of coronary artery disease (CAD). New research published in Science Translational Medicine confirmed the CAD link with a genome-wide (...)
• 01:00
  New Federal Plan to Reduce Homelessness by 25% by 2025 Includes Health Care as Part of the Solution J Am Med Assoc (JAMA)
  This Medical News feature discusses a new federal strategic plan to reduce homelessness in the US.
• 01:00
  Bird Flu Has Begun to Spread in Mammals—Here’s What’s Important to Know J Am Med Assoc (JAMA)
  This Medical News article discusses recent reports of mammal-to-mammal transmission of highly pathogenic avian influenza H5N1.
• 01:00
  Staying Home J Am Med Assoc (JAMA)
  In this narrative medicine essay, a third-year medical student who chose hospice for her infant with a life-limiting condition considers her uncertainty about whether the family may have extended their brief time together through medical (...)
• 01:00
  Measles Serostatus During Pregnancy J Am Med Assoc (JAMA)
  This observational study explores whether rubella serostatus, which is routinely assessed during pregnancy, can serve as a proxy for measles serostatus in parturient persons.
• 01:00
  A Man With Asymptomatic Ulcerated White Plaques on the Soft Palate J Am Med Assoc (JAMA)
  A man in his 60s had irregular gray-white ulcers with a surrounding erythema on the soft palate, uvula, and tonsils that did not improve with oral cefuroxime. He reported sexual contact with 1 male partner over the prior 6 months; history and physical examination findings were otherwise (...)
• 01:00
  Nonhuman “Authors” and Implications for the Integrity of Scientific Publication and Medical Knowledge J Am Med Assoc (JAMA)
  Artificial intelligence (AI) technologies to help authors improve the preparation and quality of their manuscripts and published articles are rapidly increasing in number and sophistication. These include tools to assist with writing, grammar, language, references, statistical analysis, and (...)
• 01:00
  The Existential Threat of Greed in US Health Care J Am Med Assoc (JAMA)
  In this Viewpoint, Donald Berwick explores the pursuit of profit in US health care across sectors—such as pharmaceutical companies, insurers, hospitals, and physician practices—and its harms to patients, and then offers potential (...)
• 01:00
  Misdiagnosis in the Emergency Department J Am Med Assoc (JAMA)
  This Viewpoint offers 3 insights in response to the AHRQ report on diagnostic errors made in US emergency departments: focus on the delivery systems instead of individuals, establish ways to set definitions and assess error rates, and design safe delivery systems to prevent (...)

21 February

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 01:00
  Biomarkers and the Risk of Preeclampsia J Am Med Assoc (JAMA)
  Over the past few decades, while the global incidence of preeclampsia has risen, the number of maternal and perinatal deaths due to hypertensive disorders of pregnancy has declined. In 2011, international agencies, including the World Health Organization and the UK’s National Institute for (...)
• 01:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 01:00
  Seasonal Variability of Disease J Am Med Assoc (JAMA)
  It is well known that the frequency, severity and mortality of many diseases vary with different seasons of the year. That acute respiratory infections reach a peak in the late winter months, with a minor peak in the late autumn, is attributed to a lowered local resistance to infection with the (...)
• 01:00
  Dissemination of the Results of Pediatric Clinical Trials Funded by the US National Institutes of Health J Am Med Assoc (JAMA)
  This study examines practices related to trial registration and results submission in ClinicalTrials.gov and publication of pediatric clinical trials funded by the National Institutes of Health.
• 01:00
  Review of Pulmonary Embolism J Am Med Assoc (JAMA)
  To the Editor I am writing to address several issues in the recent Review on PE. First, the authors stated that smoking is not associated with higher rates of venous thromboembolism (VTE). However, in a meta-analysis that included 3 966 184 people and 35 151 VTE events, the VTE risk increased (...)
• 01:00
  Review of Pulmonary Embolism J Am Med Assoc (JAMA)
  To the Editor The recent Review about pulmonary embolism (PE) did not mention the potential benefits of pulmonary embolism response teams (PERTs) for management of acute PE. PERTs streamline care in the setting of challenging and complex acute PE cases; facilitate rapid, effective, and (...)
• 01:00
  Review of Pulmonary Embolism J Am Med Assoc (JAMA)
  To the Editor The recent Review of PE provided 3 recommendations about antenatal PE diagnostic testing that warrant some qualification. The first addressed which pregnant persons with PE symptoms should undergo lower-limb Doppler ultrasonography prior to advanced chest imaging. As the authors (...)
• 01:00
  Roflumilast Cream vs Vehicle Cream and Chronic Plaque Psoriasis J Am Med Assoc (JAMA)
  To the Editor A recent study evaluating the safety and efficacy of roflumilast cream, 0.3%, for chronic plaque psoriasis involving 2% to 20% of body surface area concluded that daily use of roflumilast cream for 8 weeks was more effective than vehicle cream. We would like to point out some (...)
• 01:00
  Review of Pulmonary Embolism—Reply J Am Med Assoc (JAMA)
  In Reply In response to our recent Review, Dr Porres-Aguilar and colleagues highlight the potential benefits of PERTs for the management and diagnosis of PE. Although these teams may have potential to improve the prognosis of patients with diagnosed PE, data are currently scarce to support the (...)
• 01:00
  Roflumilast Cream vs Vehicle Cream and Chronic Plaque Psoriasis—Reply J Am Med Assoc (JAMA)
  In Reply In response to the Letter by Mr Smith and colleagues, we agree that studies of representative patient populations are important, but we challenge the notion that our results cannot be applied to a general population of individuals with psoriasis because only 36.3% of patients were (...)
• 01:00
  Association of African Ancestry–Specific APOE Missense Variant R145C With Risk of Alzheimer Disease J Am Med Assoc (JAMA)
  This exploratory case-control study assesses the association of APOE missense variants with risk of Alzheimer disease among individuals of African ancestry with the APOE ?3/?4 genotype.
• 01:00
  History of Low Hourly Wage and All-Cause Mortality J Am Med Assoc (JAMA)
  This longitudinal study involving US workers collected wage information during a portion of peak earning years and examined whether a history of low-wage earning was associated with mortality risk.
• 01:00
  Aspirin Discontinuation at 24 to 28 Weeks’ Gestation in Pregnancies at High Risk of Preterm Preeclampsia J Am Med Assoc (JAMA)
  This randomized clinical trial aims to determine whether aspirin discontinuation in pregnant individuals with normal soluble fms-like tyrosine kinase–1 to placental growth factor (sFlt-1:PlGF) ratio between 24 and 28 weeks of gestation was noninferior to aspirin continuation to prevent preterm (...)
• 01:00
  The Hole J Am Med Assoc (JAMA)
  The hole will be sewn shut, taking the place of the nipple. I don’t need it anyway.
• 01:00
  Notice of Retraction and Replacement. Ellison-Barnes et al. Trends in Obesity Prevalence Among Adults Aged 18 Through 25 Years, 1976-2018. JAMA . 2021;326(20):2073-2074 J Am Med Assoc (JAMA)
  To the Editor We write to explain an analytical error in our Research Letter titled “Trends in Obesity Prevalence Among Adults Aged 18 Through 25 Years, 1976-2018,” published in the November 23/30, 2021, issue of JAMA. This study looked at trends in body mass index (BMI) among young adults aged (...)
• 01:00
  Glioblastoma and Other Primary Brain Malignancies in Adults J Am Med Assoc (JAMA)
  This review summarizes current evidence regarding diagnosis and treatment of primary malignant brain tumors in adults.
• 01:00
  JAMA J Am Med Assoc (JAMA)
• 01:00
  Patient Information: Guillain-Barré Syndrome J Am Med Assoc (JAMA)
  This JAMA Patient Page describes the autoimmune disease Guillain-Barré syndrome and its risk factors, diagnosis, treatment, and prognosis.
• 01:00
  National Academies: Expand US Wastewater Disease Surveillance J Am Med Assoc (JAMA)
  Continued development of and investment in a national wastewater infectious disease surveillance system could help improve public health responses to the ongoing COVID-19 pandemic and future infectious disease outbreaks, according to a report from the National Academies of Sciences, (...)
• 01:00
  High COVID-19 Rates Prompt Call for Better Nursing Home Protections J Am Med Assoc (JAMA)
  Better nursing home protections are needed for future health emergencies, says a data brief from the US Department of Health and Human Services Office of Inspector General (OIG).
• 01:00
  Agent Slows Glioblastoma Tumors in Mice by Blocking Fat Metabolism J Am Med Assoc (JAMA)
  An investigational drug slowed glioblastoma tumor growth in a mouse model, researchers reported in Science Translational Medicine.
• 01:00
  Hybrid Immunity More Protective Than Prior SARS-CoV-2 Infection Alone J Am Med Assoc (JAMA)
  A recent systematic review of studies found that people who have been vaccinated against COVID-19 and have had a previous SARS-CoV-2 infection, known as having hybrid immunity, have better protection against the Omicron variant than those with only a previous (...)
• 01:00
  New Report on Mpox Cases Leading Up to 2022 Global Outbreak J Am Med Assoc (JAMA)
  From January 1, 2022, through January 27, 2023, more than 85 000 confirmed human mpox (monkeypox) cases in 110 countries and 86 deaths were reported to the World Health Organization.
• 01:00
  Nearly 500 000 in UK May Have Missed Blood Pressure Drugs J Am Med Assoc (JAMA)
  An estimated 491 000 fewer people than expected began antihypertensive medications in the UK between March 2020 and July 2021 during the COVID-19 pandemic. The decline, reported in Nature Medicine, could result in more than 13 000 additional cardiovascular disease events, including nearly 2300 (...)
• 01:00
  Both High- and Low-Dose Exercise Therapy Help Knee Osteoarthritis J Am Med Assoc (JAMA)
  For patients with pain and decreased knee function from osteoarthritis, high-dose exercise therapy is not superior to low-dose therapy for most outcomes, according to the results of a randomized trial.
• 01:00
  Vasopressors or High-Volume IV Fluids Both Effective for Sepsis J Am Med Assoc (JAMA)
  Patients with sepsis-induced hypotension resuscitated in the first 24 hours with lower volumes of intravenous fluid and greater vasopressor use were about as likely to survive as patients treated with higher intravenous fluid volumes prioritized over vasopressors. The trial results, reported in (...)
• 01:00
  Newly Discovered Host-Cell Factor Could Be a COVID-19 Treatment Target J Am Med Assoc (JAMA)
  The discovery of a molecular factor that helps many types of coronaviruses invade host cells could lead to COVID-19 treatments that retain effectiveness as SAR-CoV-2 mutates, according to a study in Proceedings of the National Academy of (...)
• 01:00
  New HIV Vaccine Approach Safely Stimulated Rare Precursors to Broadly Neutralizing Antibodies J Am Med Assoc (JAMA)
  This Medical News article discusses a clinical trial for an HIV vaccine that uses germline targeting, a novel technique to induce rare immune cell precursors of broadly neutralizing antibodies.
• 01:00
  Study Finds US Households Increasingly Shop at Dollar Stores for Food J Am Med Assoc (JAMA)
  This Medical News article discusses a new study of household food purchasing trends from 2008 to 2020.
• 01:00
  Sanctity J Am Med Assoc (JAMA)
  In this narrative medicine essay, an obstetrician finds relief from the frenetic intrusions of text messages, pages, and emails when in the operating room, where all devices are turned off and all her attention is turned on to her (...)
• 01:00
  Risk Factors, Symptoms, and Treatment of Lactational Mastitis J Am Med Assoc (JAMA)
  This JAMA Insights Clinical Update reviews the risk factors for and symptoms of lactational mastitis and provides a potential treatment algorithm.
• 01:00
  The Importance of Shifting Sepsis Quality Measures From Processes to Outcomes J Am Med Assoc (JAMA)
  This Viewpoint discusses the failure of the Centers for Medicare & Medicaid Services’ SEP-1 sepsis outcome improvement initiative to improve patients’ sepsis outcomes and suggests changing the focus of sepsis quality metrics from processes to (...)
• 01:00
  Assessing California’s Insulin Manufacturing Initiative J Am Med Assoc (JAMA)
  This Viewpoint reviews California’s recently proposed CalRx initiative to manufacture biosimilar insulin, highlights challenges facing the initiative, and suggests ways in which, if successful, the initiative could serve as a model for state-managed development of drugs other than insulin, (...)

14 February

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 01:00
  SARS-CoV-2 Infections and Presymptomatic Type 1 Diabetes Autoimmunity in Children and Adolescents—Reply J Am Med Assoc (JAMA)
  In Reply We welcome the opportunity to address the comments expressed by Dr Chang about our recent Research Letter, which found no association between SARS-CoV-2 infection and presymptomatic type 1 diabetes.
• 01:00
  Tracking All Injuries From Firearms in the US—Reply J Am Med Assoc (JAMA)
  In Reply In our Viewpoint, we argued that focusing nearly exclusively on fatal firearm injuries neglects the magnitude, impact, and variation of nonfatal injuries, which outnumber deaths by at least 2 to 1. It is indeed likely that emergency department encounters underestimate total injuries (...)
• 01:00
  Effect of Low-Concentration Atropine Eyedrops vs Placebo on Myopia Incidence in Children J Am Med Assoc (JAMA)
  This randomized placebo-controlled trial examines the efficacy of low-concentration atropine eyedrops (0.05% and 0.01% concentration) for delaying the onset of myopia in children vs placebo.
• 01:00
  Discriminative Accuracy of the CAPTURE Tool for Identifying COPD in US Primary Care Settings J Am Med Assoc (JAMA)
  This cross-sectional study evaluates the operating characteristics of the CAPTURE screening tool by identifying US primary care patients with undiagnosed, clinically significant COPD.
• 01:00
  Patient Information: Screening for Genital Herpes J Am Med Assoc (JAMA)
  This JAMA Patient Page summarizes the US Preventive Services Task Force’s recent recommendations on screening for genital herpes infection.
• 01:00
  Tinnitus J Am Med Assoc (JAMA)
  Occasionally it sounds like a cathedral tower full of bells but usually it’s more like the last scatter of cicadas at the end of summer, an almost pleasant buzz and whirr, though with a slightly higher pitch, as at night once the light has gone and daytime noise has faded. Crescendos rise then (...)
• 01:00
  Beautiful Noise J Am Med Assoc (JAMA)
  Poetry has long drawn on the noisiness of the human body to make music from language. It’s not difficult to imagine that the impulse to create poetry with meter, perhaps the most audibly “musical” of poetic forms, originates with the heartbeat itself, the unstressed-stressed S1-S2 or “lub-DUB” (...)
• 01:00
  Delivering Bad News Badly J Am Med Assoc (JAMA)
  In this narrative medicine essay, a resident physician practicing how to deliver bad diagnostic news to patients struck a balance upon learning that authenticity and presence were more important than the exact words he chose.
• 01:00
  JAMA J Am Med Assoc (JAMA)
• 01:00
  USPSTF Recommendation: Serologic Screening for Genital Herpes Infection J Am Med Assoc (JAMA)
  This 2023 Recommendation Statement from the US Preventive Services Task Force recommends against routine serologic screening for genital HSV infection in asymptomatic adolescents and adults, including pregnant persons (D recommendation).
• 01:00
  Household Transmission of Influenza A Viruses in 2021-2022 J Am Med Assoc (JAMA)
  This prospective study compares the risk of transmission of influenza virus infection among household contacts of patients with influenza during the 2021-2022 influenza season vs before the COVID-19 pandemic influenza seasons in the (...)
• 01:00
  Changes in p53 Gene May Influence Cardiovascular Disease Risk J Am Med Assoc (JAMA)
  Scientists have discovered that genetic changes in blood cells, specifically in the key DNA damage repair gene that encodes p53—a well-known tumor suppression protein—can contribute to atherosclerosis risk, in addition to cancer.
• 01:00
  Wildfire Exposure Linked to Changes in Cognition and Brain Activity J Am Med Assoc (JAMA)
  Researchers found that experiencing a wildfire is associated with worse performance on a cognitive test as well as heightened activity in the frontal part of the brain 6 to 12 months after the event. The recent findings are among the first to tie trauma from a climate event to long-term changes (...)
• 01:00
  Plan Calls for Global Collaboration to Address Child Undernutrition J Am Med Assoc (JAMA)
  Conflict, climate events, the COVID-19 pandemic, and climbing costs of living have contributed to a severe form of undernutrition among an increasing number of children, according to the World Health Organization (WHO).
• 01:00
  Stroke Risk From Diabetes, High Blood Pressure May Decrease With Age J Am Med Assoc (JAMA)
  Research appearing in Neurology found that the risk for stroke due to select factors was lower in magnitude at older ages.
• 01:00
  NIH Funds Research on Severe COVID-19–Related Illness in Children J Am Med Assoc (JAMA)
  As of January 3, 9333 young people in the US have been diagnosed with multisystem inflammatory syndrome in children (MIS-C), a rare condition characterized by severe organ inflammation, and 76 have died, according to the Centers for Disease Control and Prevention COVID data (...)
• 01:00
  New CT Scan Distinguishes Primary Aldosteronism Subtypes J Am Med Assoc (JAMA)
  Physicians often distinguish between different forms of primary aldosteronism, a common cause of high blood pressure, using adrenal vein sampling, which can be invasive and is not widely available.
• 01:00
  Medicaid Expansion Tied to Reduction in Postpartum Hospitalizations J Am Med Assoc (JAMA)
  iStock.com/andresr
• 01:00
  Gender-Affirming Hormones and Youth Well-being J Am Med Assoc (JAMA)
  Overall, youth who received gender-affirming hormones (GAH) for 2 years improved on several measures of well-being, according to the findings of a prospective observational study published in the New England Journal of Medicine. The study involved 315 transgender and nonbinary participants aged (...)
• 01:00
  Integrative Therapies Lessen Postsurgical Anxiety, Pain J Am Med Assoc (JAMA)
  Patients with cancer who received a touch-based relaxation intervention before undergoing a surgical procedure had more favorable scores on measures of anxiety and depression after the operation than those who did not undergo the intervention, according to research published in Cancer. Adding (...)
• 01:00
  Ceasefire Declared, but Ethiopian Health Systems Remain in Critical Condition After Civil War J Am Med Assoc (JAMA)
  This Medical News article discusses the total collapse of health care systems in Ethiopia during a 2-year armed conflict.
• 01:00
  Large Cohort Study Finds Possible Association Between Postural Orthostatic Tachycardia Syndrome and COVID-19 Vaccination but Far Stronger Link With SARS-CoV-2 Infection J Am Med Assoc (JAMA)
  This Medical News story discusses a study that found possible associations between postural orthostatic tachycardia syndrome (POTS) and COVID-19 vaccination and SARS-CoV-2 infection.
• 01:00
  Conditional Power J Am Med Assoc (JAMA)
  This JAMA Guide to Statistics and Methods article examines conditional power, calculated while a trial is ongoing and based on both the currently observed data and an assumed treatment effect for future patients.
• 01:00
  Collective —Documentary of a National Health Care Tragedy J Am Med Assoc (JAMA)
  This Arts and Medicine feature reviews the 2019 movie Collective, which documents corruption underlying poor patient outcomes in the Romanian national health system and provides an update on the people and reform efforts featured in the (...)
• 01:00
  Recent Patent Reform Bills and Their Implications for Prescription Drugs J Am Med Assoc (JAMA)
  This Viewpoint discusses 3 bills introduced recently in Congress that focus on patent eligibility, fraud, and quality and that have major implications for clinical medicine and pharmaceutical development.
• 01:00
  The CRISPR Patent Ruling and Implications for Medicine J Am Med Assoc (JAMA)
  This Viewpoint discusses the CRISPR patent ruling, an ongoing patent dispute, and the implications for research and medical innovation.
• 01:00
  Quantitative Analyses of Regulatory Policies for Medical Devices J Am Med Assoc (JAMA)
  The US Food and Drug Administration (FDA) review of new medical devices attempts to balance access to new and useful technology alongside determinations of “reasonable assurance of safety and effectiveness.” Most reviewed devices receive clearance for marketing through the 510(k) pathway, the (...)
• 01:00
  Incorrect Units of Measure in a Table J Am Med Assoc (JAMA)
  In the Original Investigation titled “Effect of Remifentanil vs Neuromuscular Blockers During Rapid Sequence Intubation on Successful Intubation Without Major Complications Among Patients at Risk of Aspiration: A Randomized Clinical Trial,” published in the January 3, 2023, issue of JAMA, the (...)
• 01:00
  Error in Box J Am Med Assoc (JAMA)
  The Review titled “Progress and Challenges in Bacterial Meningitis: A Review,” published in the December 6, 2022, issue of JAMA, included an error in the Introduction indicating an incorrect estimated years of life lost from bacterial meningitis and an error in the Box indicating that viral, (...)
• 01:00
  Delaying the Onset of Nearsightedness J Am Med Assoc (JAMA)
  Myopia, or nearsightedness, affects approximately 23% of the world’s population, and the prevalence is expected to increase to 50% by 2050. In the US, approximately one-third of the population is myopic, and this is expected to increase to almost 60% by 2050. The estimated annual direct cost of (...)
• 01:00
  Reducing HSV-2 Morbidity and Mortality J Am Med Assoc (JAMA)
  Humans are the only natural host and reservoir of herpes simplex virus (HSV) types 1 (HSV-1) and 2 (HSV-2), and together HSV is among the most prevalent viral infections in the world. After a primary genital infection with HSV, these viruses establish lifelong latency in the nonreplicating (...)
• 01:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 01:00
  Vital Statistics in Prognosis J Am Med Assoc (JAMA)
  It has been well said that prognosis is the map by means of which the physician leads his patient through the barren land of disease. To the patient, a favorable prognosis affords immeasurable courage and fortitude. Still, such figures as 50 per cent. mortality in cerebrospinal meningitis, (...)
• 01:00
  USPSTF Review: Serologic Screening for Genital Herpes J Am Med Assoc (JAMA)
  This systematic review to support the 2023 US Preventive Services Task Force Recommendation Statement on serologic screening for genital herpes summarizes published evidence on the benefits and harms of screening and interventions for genital herpes in asymptomatic sexually active adolescents, (...)
• 01:00
  Approaches to Prevention of Firearm Violence J Am Med Assoc (JAMA)
  To the Editor The recent Viewpoint entitled “Firearms, Suicide, and Approaches for Prevention” focused on lethal means safety, an essential element of evidence-based suicide prevention programs. This approach limits access by either removing firearms from the home or by improving the security of (...)
• 01:00
  SARS-CoV-2 Infection and Presymptomatic Type 1 Diabetes Autoimmunity in Children and Adolescents J Am Med Assoc (JAMA)
  To the Editor I have several concerns about the recent study that found no significant association of SARS-CoV-2 infection with autoimmunity related to type 1 diabetes in groups of children and adolescents from Colorado and from Bavaria, (...)
• 01:00
  Tracking All Injuries From Firearms in the US J Am Med Assoc (JAMA)
  To the Editor We submit this Letter in response to the recent Viewpoint about a national surveillance system for firearm violence. Dr Cook is an epidemiologist whose children witnessed the Parkland, Florida, mass shooting; Dr Sills is an emergency physician-scientist who has worked in trauma (...)
• 01:00
  Approaches to Prevention of Firearm Violence—Reply J Am Med Assoc (JAMA)
  In Reply Dr Nathan’s thoughtful letter highlights 2 often overlooked elements in suicide prevention: the profound effects of suicide among affected populations, and the critical role of policy in prevention. In the US in 2020, there were nearly 46 000 suicide deaths, or approximately 1 every 11 (...)

7 February

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 01:00
  NIH Pilots Telehealth Program for COVID-19 J Am Med Assoc (JAMA)
  A pilot program that allows telehealth consultation and antiviral treatment for COVID-19 without leaving home launches this January in Pennsylvania.
• 01:00
  AAP Recommends Immediate, Intensive Treatment for Child Obesity J Am Med Assoc (JAMA)
  In its first comprehensive guidance in 15 years on childhood overweight and obesity, the American Academy of Pediatrics (AAP) recommends comprehensive assessment and immediate, intensive treatment for children and teens who are at or above the 85th percentile of body mass index (BMI) for their (...)
• 01:00
  Sickle Cell Disease Gene Therapy Trial Paused J Am Med Assoc (JAMA)
  A phase 1 and 2 clinical trial of a new gene editing technique to treat sickle cell anemia was voluntarily paused by its sponsor after a severe, likely treatment-related, adverse event occurred with the first patient treated.
• 01:00
  Letters to Clinicians May Promote Better-Informed Opioid Prescribing J Am Med Assoc (JAMA)
  Letters reminding clinicians of a mandate to check a state prescription tracking database before prescribing opioids significantly increased clinician participation in the program. The approach may promote better-informed and potentially safer opioid prescribing, according to a study in Health (...)
• 01:00
  Patients With Mild COVID-19 at Risk of Some Post–COVID-19 Condition Symptoms J Am Med Assoc (JAMA)
  Patients who were diagnosed with mild COVID-19 were up to 4.6 times more likely than uninfected patients to have some symptoms associated with post–COVID-19 condition (PCC) for 6 to 12 months, according to a study in The BMJ.
• 01:00
  From Thought to Text: How an Endovascular Brain-Computer Interface Could Help Patients With Severe Paralysis Communicate J Am Med Assoc (JAMA)
  This Medical News article discusses a recent clinical trial of a brain-computer interface implanted through the vascular system.
• 01:00
  The Debate Over Whether to Swab the Throat When Testing for SARS-CoV-2 J Am Med Assoc (JAMA)
  This Medical News article discusses whether swabbing both the nose and the throat might improve the sensitivity of rapid antigen COVID-19 tests.
• 01:00
  Pharmacy Benefit Managers and the FTC J Am Med Assoc (JAMA)
  This Viewpoint provides a brief history of pharmacy benefit managers (PBMs), describes the ways in which PBMs have acquired influence in the prescription drug distribution system, and suggests possible scenarios surrounding the June 2022 decision by the Federal Trade Commission to launch an (...)
• 01:00
  Pulse Oximeters and Violation of Federal Antidiscrimination Law J Am Med Assoc (JAMA)
  This Viewpoint discusses how some pulse oximeters can provide incorrect oxygen saturation data for dark-skinned patients compared with light-skinned patients, describes the reasons that biased oximeters remained in use, and highlights why a rule recently proposed by the US Department of Health (...)
• 01:00
  Spending on Direct-to-Consumer Advertising for Pharmaceutical Products J Am Med Assoc (JAMA)
  The tension between physicians and drugmakers, especially over marketing, dates to the era of patent medicines. Since 1997, pharmaceutical manufacturers have advertised directly to US consumers, amplifying controversy over the role of drug marketing in clinical care. Critics argue that (...)
• 01:00
  Adverse Pregnancy Outcomes—Risk Enhancers Whose Time Has Finally Arrived J Am Med Assoc (JAMA)
  Heart disease is the leading cause of death globally for both sexes, affecting 1 in 5 women in the United States. Although women have a lower prevalence of obstructive epicardial coronary artery disease compared with men of a similar age, they have higher rates of myocardial ischemia and (...)
• 01:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 01:00
  Congressional Testimony J Am Med Assoc (JAMA)
  Testimony on Dec 7, 1972, before the Senate Monopoly Subcommittee on the Prescribing of Antibiotics reflects both the bias and the limited experience of the witnesses. The testimony was not by physicians in the active practice of medicine, but from men who serve in government, medical (...)
• 01:00
  Accuracy of EHR Food Insecurity, Housing Instability, and Financial Strain Screening in Adult Primary Care J Am Med Assoc (JAMA)
  This study assesses the accuracy of electronic health record–based screening questionnaires about social risk factors using external single-domain questionnaires as a comparator.
• 01:00
  SARS-CoV-2 Results in Self-collected Nasal Swabs vs Swabs Collected by Health Care Workers in Children and Adolescents J Am Med Assoc (JAMA)
  To the Editor We have several comments about the recent study that concluded that nasal swabs collected by children and adolescents have similar diagnostic performance to those collected by health care professionals.
• 01:00
  Vaccination, Acute Myocardial Infarction, and Ischemic Stroke After COVID-19 Infection J Am Med Assoc (JAMA)
  To the Editor We would like to highlight some key points about the recent article that reported that patients who received full vaccination against COVID-19 had a reduced risk of acute myocardial infarction (AMI) and ischemic stroke after COVID-19 (...)
• 01:00
  Mpox Outbreak Update J Am Med Assoc (JAMA)
  To the Editor A recent Viewpoint provided an update about the current global outbreak of human mpox (monkeypox). Although this article increases clinical knowledge about mpox, I have 2 concerns about this Viewpoint.
• 01:00
  SARS-CoV-2 Results in Self-collected Nasal Swabs vs Swabs Collected by Health Care Workers in Children and Adolescents—Reply J Am Med Assoc (JAMA)
  In Reply We appreciate the letter from Drs Hong and Sung about our study, which demonstrated the ability of children and adolescents to self-collect samples for respiratory virus testing and independently participate in their medical (...)
• 01:00
  Vaccination, Acute Myocardial Infarction, and Ischemic Stroke After COVID-19 Infection—Reply J Am Med Assoc (JAMA)
  In Reply We thank Dr Chu and colleagues for their comments about our Research Letter. Our analysis found that 2 doses of COVID-19 vaccine were associated with a reduced risk of AMI and ischemic stroke after COVID-19, using inverse probability treatment weighting to mitigate the imbalance in (...)
• 01:00
  Mpox Outbreak Update—Reply J Am Med Assoc (JAMA)
  In Reply We thank Dr Zhou for the thoughtful Letter in response to our Viewpoint. The global mpox outbreak is clearly evolving and knowledge about this infection is rapidly changing. When the Viewpoint was published on August 11, 2022, the US Food and Drug Administration (FDA) had not approved (...)
• 01:00
  Association Between Drug Characteristics and Manufacturer Spending on Direct-to-Consumer Advertising J Am Med Assoc (JAMA)
  This pharmacoeconomic study estimates associations between drug characteristics and the proportion of manufacturer promotional spending allocated to direct-to-consumer advertising.
• 01:00
  History of Adverse Pregnancy Outcomes and Coronary Artery Disease Assessed by Coronary CT Angiography J Am Med Assoc (JAMA)
  This study assesses the association of history of adverse pregnancy outcomes with subsequent image-identified coronary artery disease among a population-based cohort of women in Sweden.
• 01:00
  Intravitreous Aflibercept for Prevention of Vision-Threatening Complications of Diabetic Retinopathy J Am Med Assoc (JAMA)
  This randomized clinical trial analyzes the effects of aflibercept injections vs sham for reducing disease progression and improving long-term visual acuity in patients with nonproliferative diabetic retinopathy.
• 01:00
  Patient Information: Ectopic Pregnancy J Am Med Assoc (JAMA)
  This JAMA Patient Page describes ectopic pregnancy and its risk factors, symptoms, diagnosis, and treatment.
• 01:00
  Visitation J Am Med Assoc (JAMA)
  During the last visit, we drank coffee and ate laughter. You didn’t recognize my face, which was your face. I watched you sink into the fur of your chair. That night, I held you in my arms, realized your smallness. You didn’t recognize my face, but still asked if I had eaten, eyes like caskets. (...)
• 01:00
  Gray Hair J Am Med Assoc (JAMA)
  In this narrative medicine essay, a chair of a family medicine department views the wide generation gap between him and his medical students as an unexpected turn from what he had imagined he would feel upon becoming a senior (...)
• 01:00
  Management of Menopausal Symptoms J Am Med Assoc (JAMA)
  This narrative review discusses treatments for women with bothersome vasomotor symptoms (hot flashes, night sweats, or both) and genitourinary syndrome of menopause (genitourinary symptoms), which include hormonal and nonhormonal (...)
• 01:00
  JAMA J Am Med Assoc (JAMA)
• 01:00
  Management of Latent Tuberculosis Infection J Am Med Assoc (JAMA)
  This JAMA Insights Clinical Update examines treatment recommendations and therapy options among adults with latent tuberculosis infection.
• 01:00
  More Medical News Clinicians Can Use J Am Med Assoc (JAMA)
  For more than a century, JAMA’s Medical News department has illuminated timely topics in clinical medicine, biomedical research, public health, and health policy from across the spectrum of scientific publishing and the landscape of health and medicine. As a new year begins—year 4 of the COVID-19 (...)
• 01:00
  Lecanemab Gains FDA Approval for Early Alzheimer Disease J Am Med Assoc (JAMA)
  A treatment that may moderately slow mild cognitive decline and reduce amyloid-? plaques in patients with early Alzheimer disease gained accelerated approval from the US Food and Drug Administration (FDA). Lecanemab-irmb, marketed as Leqembi by Eisai and Biogen, is indicated for patients with (...)
• 01:00
  Substance Use, Mental Health Challenges Widespread in 2021 J Am Med Assoc (JAMA)
  More than 46 million people (16.5%) aged 12 years or older in the US met clinical criteria for substance use disorders in 2021, whereas nearly 1 in 4 adults aged 18 years or older reported a mental illness, according to the 2021 National Survey of Drug Use and Health conducted by the federal (...)
• 01:00
  Gene Edited Tumor Cells Kill and Prevent Cancer in Mice J Am Med Assoc (JAMA)
  Live cancer cells genetically altered to both attack cancer tumors and stimulate immunity eliminated established glioblastoma tumors and prevented recurrence in mice, according to a report in Science Translational Medicine. The results suggest that cell-based immunotherapies for treating solid (...)
• 01:00
  Child Asthma Tied to Specific Urban Air Pollutants J Am Med Assoc (JAMA)
  Ozone and fine particulate matter are associated with increased asthma exacerbations in children living in urban areas. Moreover, these pollutants appear linked to specific inflammation patterns distinct from each other and from viral asthma, according to a study in The Lancet Planetary (...)

24 January

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 01:00
  Incorrect Affiliations J Am Med Assoc (JAMA)
  In the Letter to the Editor titled “SARS-CoV-2 Reduction in Shared Indoor Air,” published in the December 6, 2022, issue of JAMA, the author affiliations were incorrectly listed. Mr Srikrishna’s affiliation is PatientKnowhow.com, San Mateo, California; Dr Karan’s affiliation is the Division of (...)
• 01:00
  Health Systems—The Present and the Future J Am Med Assoc (JAMA)
  For better or worse, independent medical practices and solo community hospitals are disappearing as they are acquired by hospital-based health systems. In this issue of JAMA, Beaulieu et al provide a detailed review of the current (2018) prevalence and performance of the 580 health systems they (...)
• 01:00
  Poetry and Medicine and New Poetry Commentaries in JAMA J Am Med Assoc (JAMA)
  “I find that I cannot exist without poetry” proclaimed John Keats, the beloved English Romantic poet who many forget was trained as a physician. Keats practiced medicine for only 7 years before abandoning the profession. The medicine of his day, in early 19th-century London, faced dire challenges (...)
• 01:00
  Sequential, Multiple Assignment, Randomized Trial Designs J Am Med Assoc (JAMA)
  This JAMA Guide to Statistics and Methods explains sequential, multiple assignment, randomized trial (SMART) study designs, in which some or all participants are randomized at 2 or more decision points depending on the participant’s response to prior (...)
• 01:00
  Government Accountability Office Examines Political Interference Among US Health Agencies J Am Med Assoc (JAMA)
  Several agencies under the US Department of Health and Human Services (HHS) aren’t adequately shielded against political interference, according to a report by the US Government Accountability Office (GAO).
• 01:00
  Updated Demographics and Health Stats for Older Adults Released J Am Med Assoc (JAMA)
  The Administration for Community Living (ACL), through its Administration on Aging, released updated demographics for the US population aged 65 years or older. Data were sourced from the Bureau of Labor Statistics, the National Center for Health Statistics, and the US Census (...)
• 01:00
  CMS Recommends Standardizing “Health Care Attachments” J Am Med Assoc (JAMA)
  The Centers for Medicare & Medicaid Services (CMS) proposed a rule to standardize electronic signatures and health care attachment transactions, such as medical charts and x-rays. If finalized, the rule would also standardize notes documenting physician referrals and office and (...)
• 01:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 01:00
  Efficiency in Medicine J Am Med Assoc (JAMA)
  In addition to the many profound changes in the living conditions of mankind which the World War served to bring about, the exigencies developed by the great conflict have helped in a large way to emphasize the possible significance of efficiency and organization in the conduct of human (...)
• 01:00
  Trends in Sexual Assault Against Detainees in US Immigration Detention Centers, 2018-2022 J Am Med Assoc (JAMA)
  This study examines sexual assault allegations perpetrated against individuals detained across US Immigration and Customs Enforcement (ICE) detention facilities from 2018 to 2022.
• 01:00
  Racial Differences in Detection of Fever Using Temporal vs Oral Temperature Measurements J Am Med Assoc (JAMA)
  To the Editor A recent Research Letter reported that temperatures measured by temporal thermometers are lower than those measured orally in Black patients but not in White patients. However, I am concerned that this study used race as a proxy for skin color. Because people can have a range of (...)
• 01:00
  Racial Differences in Detection of Fever Using Temporal vs Oral Temperature Measurements J Am Med Assoc (JAMA)
  To the Editor A recent Research Letter examined temperatures generated with temporal artery thermometers with the goal of identifying systemic bias in medical devices. As one of us (F.P.) is the inventor of the temporal artery thermometer, and as we are scientists working for its manufacturer, (...)
• 01:00
  Improvements in Adverse Event Rates Among Hospitalized Patients J Am Med Assoc (JAMA)
  To the Editor I have some concerns about the Editorial that was written about our recent article. First, the Editorial stated that “…patients may be less convinced that risk-adjusted annual declines of 6% in the rates of acute myocardial infarction or pneumonia, for instance, imply that hospitals (...)
• 01:00
  Racial Differences in Detection of Fever Using Temporal vs Oral Temperature Measurements—Reply J Am Med Assoc (JAMA)
  In Reply We thank the authors for their comments about our recent article exploring racial differences in the accuracy of temporal thermometers. We agree with Dr Newman that self-reported race is an imperfect proxy for skin color. If differences in skin color are the basis of the temperature (...)
• 01:00
  Improvements in Adverse Event Rates Among Hospitalized Patients—Reply J Am Med Assoc (JAMA)
  In Reply “The goal is zero harms” has resonated throughout patient safety. Two decades after To Err Is Human, health care continues to face recurrences of a multitude of preventable adverse events. No guideline, policy, or public health intervention has been able to eliminate adverse (...)
• 01:00
  Low-Carbohydrate, High-Fat Diet Improved Type 2 Diabetes Without Restricting Calories J Am Med Assoc (JAMA)
  People with type 2 diabetes who ate a low-carbohydrate, high-fat (LCHF) diet for 6 months had better glycemic control than those who ate a high-carbohydrate, low-fat (HCLF) diet, a recent trial reported, but the differences weren’t sustainable 3 months after the (...)
• 01:00
  More Durable Pelvic Floor Muscle Training With Digital Device J Am Med Assoc (JAMA)
  The use of a motion-based digital therapeutic device to guide pelvic-floor muscle training led to greater improvement of urinary incontinence symptoms for up to 12 months compared with standard self-guided exercises a recent study (...)
• 01:00
  Ebola Vaccines Safe and Immunogenic in 2 Trials J Am Med Assoc (JAMA)
  Three vaccine regimens against Zaire Ebola virus disease safely produced immune responses for up to 12 months, according to 2 trials of adults and children reported in the New England Journal of Medicine.
• 01:00
  Novel Oral Polio Vaccine Safely Induces Antibodies Among Vaccine-Naive Infants J Am Med Assoc (JAMA)
  A novel oral poliovirus vaccine type 2 (nOPV2) was well-tolerated among newborns and resulted in nearly all infants developing neutralizing antibodies after 2 doses, a recent trial reported.
• 01:00
  Accuracy of Stroke Risk Prediction Models by Race, Sex, and Age J Am Med Assoc (JAMA)
  This retrospective cohort study compares stroke-specific algorithms with pooled cohort equations developed for atherosclerotic cardiovascular disease for the prediction of new-onset stroke across different subgroups (race, sex, and age) and the added value of novel machine learning (...)
• 01:00
  Estimated Prevalence and Clinical Manifestations of UBA1 Variants Associated With VEXAS Syndrome J Am Med Assoc (JAMA)
  This retrospective observational study evaluates UBA1 variants in exome data from individuals in the Geisinger MyCode Community Health Initiative.
• 01:00
  Patient Information: Rabies J Am Med Assoc (JAMA)
  This JAMA Patient Page describes rabies and its symptoms, diagnosis, and prevention measures.
• 01:00
  Viva Las Vagus J Am Med Assoc (JAMA)
  I fall for you every time I look at blood, especially when my own gurgles into a test tube or drib-drabs onto the floor, or when my knees lock from standing too long in one place, or even when I eye a needle pointed at me. Once
• 01:00
  Vagal Maneuvers J Am Med Assoc (JAMA)
  This issue’s poem, “Viva Las Vagus,” takes the reader on an appropriately wandering, at times dizzying journey, beginning with its title’s jokey, far-out allusion to, yes, the 1964 Elvis Presley movie. As the poem unspools we veer between playful camp and profound physical experience of our (...)
• 01:00
  Next Year J Am Med Assoc (JAMA)
  In this narrative medicine essay, a pediatrician whose youngest child will start college next fall contemplates how she will shift focus on her career without competing interests.
• 01:00
  Organization and Performance of US Health Systems J Am Med Assoc (JAMA)
  This Special Communication examines health systems in the United States, assesses differences between physicians and hospitals in and outside of health systems, and compares quality and cost of care delivered by physicians and hospitals in and outside of health (...)
• 01:00
  JAMA J Am Med Assoc (JAMA)
• 01:00
  Disentangling the Role of Health Care Systems in Producing High-Quality Care J Am Med Assoc (JAMA)
  This Viewpoint examines in-depth 5 features of health care systems that may influence quality of care: pooled resources, centralization, standardization, interprovider coordination, and cross-practice learning.
• 01:00
  US Life Expectancy in 2021 Lowest Since 1996 J Am Med Assoc (JAMA)
  Life expectancy in the US decreased by about a half year between 2020 and 2021, from 77 years to 76.4 years, according to final 2021 mortality data from the National Center for Health Statistics. Life expectancy in 2021 was at its lowest level since 1996. The report attributed the drop mainly (...)
• 01:00
  Fentanyl Drives Startling Increases in Adolescent Overdose Deaths J Am Med Assoc (JAMA)
  Almost 107 000 US individuals died from a drug overdose in 2021, continuing a 2-decade-long trend of increasing overdose deaths that accelerated during the pandemic, according to a National Center for Health Statistics report.
• 01:00
  Lack of Benefit of Fluvoxamine for COVID-19 J Am Med Assoc (JAMA)
  The COVID-19 pandemic caught society unprepared. The lack of therapeutic agents for coronaviruses led to a scramble to investigate approved medications for repurposing against SARS-CoV-2. Successes were achieved with immunomodulatory agents for the inflammatory disease processes of COVID-19, (...)
• 01:00
  Effect of Fluvoxamine vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19 J Am Med Assoc (JAMA)
  This randomized, placebo-controlled platform trial compares the use of low-dose fluvoxamine (50 mg twice daily) for 10 days compared with placebo in outpatients with mild to moderate COVID-19.
• 01:00
  Billing Patient Portal Messages as e-Visits and Patient Messaging Volume J Am Med Assoc (JAMA)
  This study evaluates the adoption of clinician billing for patient portal messages as e-visits, prompted by significant increases in patient messaging after the onset of the COVID-19 pandemic.
• 01:00
  Prevention of Bias and Discrimination in Clinical Practice Algorithms J Am Med Assoc (JAMA)
  This Viewpoint discusses a proposed DHHS rule to address discrimination in clinical algorithms and the need for additional considerations to ensure the burden of liability for biased algorithms is not disproportionately placed on health care (...)
• 01:00
  Clinical Algorithms, Antidiscrimination Laws, and Medical Device Regulation J Am Med Assoc (JAMA)
  This Viewpoint discusses recent legal directives by the DHHS and FDA that could increase health care entities’ liability for possible discriminatory biases of clinical algorithms and the need for additional legal clarity to avoid adverse effects on algorithm development and (...)
• 01:00
  Study: Short Spurts of Vigorous Physical Activity During Daily Life Are Associated With Lower Mortality J Am Med Assoc (JAMA)
  This Medical News article discusses a recent study that investigated the benefits of brief bursts of intense physical activity during daily life.

17 January

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 01:00
  Incorrect Term J Am Med Assoc (JAMA)
  In the JAMA Clinical Guidelines Synopsis titled “Management of Heart Failure,” published in the October 4, 2022, issue of JAMA, an incorrect term was used. In the last paragraph of text, third sentence, the term “magnetic resonance angiography” should have read “mineralocorticoid receptor (...)
• 01:00
  TRANSFORM-HF—Can We Close the Loop on Diuretics in Heart Failure? J Am Med Assoc (JAMA)
  Fluid overload is the cardinal manifestation of heart failure, and prior to the 20th century, treatment options were limited to purgatives, bloodletting, leeching, or lancing. It was not until 1920 that the concept of a diuretic was first appreciated, when physicians observed increased (...)
• 01:00
  FDA Warns of Risks of Body Sculpting J Am Med Assoc (JAMA)
  iStock.com/andresr
• 01:00
  New Gene Therapy for Certain Bladder Cancers J Am Med Assoc (JAMA)
  The first gene therapy for treating high-risk bladder cancer that has not invaded muscle recently won FDA approval.
• 01:00
  Updated Labeling for Capecitabine, a 25-Year-Old Cancer Drug J Am Med Assoc (JAMA)
  The FDA recently approved updated labeling for capecitabine (Xeloda) tablets, the first under a pilot program initiative to update labeling information for some older oncology drugs. Many oncology products have outdated labeling, and revising them could reduce potential risk to patients, (...)
• 01:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 01:00
  Psychosomatic Medicine and "The Art of Medicine" J Am Med Assoc (JAMA)
  For fifty years deans of medical schools and speakers before graduating medical classes have stressed the never to be forgotten importance of practicing the art as well as the science of medicine. The art of medicine, they said frequently, was not taught in medical schools but gained only after (...)
• 01:00
  Timing of Blood Draws Among Patients Hospitalized in a Large Academic Medical Center J Am Med Assoc (JAMA)
  This study describes the degree to which blood draws occurred among hospitalized patients during traditional sleep hours and investigates trends over time.
• 01:00
  Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy and Survival of Patients With Low-Risk Nasopharyngeal Carcinoma J Am Med Assoc (JAMA)
  To the Editor The National Comprehensive Cancer Network (NCCN) guidelines currently recommend that concurrent chemoradiotherapy be the primary treatment for patients with T1-2N1M0, T3N0M0, and T2N0M0 NPC with high-risk features. A recent study reported that patients with low-risk stage II and (...)
• 01:00
  Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy and Survival of Patients With Low-Risk Nasopharyngeal Carcinoma J Am Med Assoc (JAMA)
  To the Editor We have several comments about the recent study that found that intensity-modulated radiation therapy (IMRT) alone was not inferior for 3-year failure-free survival compared with concurrent chemoradiotherapy in patients with low-risk nasopharyngeal carcinoma (...)
• 01:00
  Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy and Survival of Patients With Low-Risk Nasopharyngeal Carcinoma J Am Med Assoc (JAMA)
  To the Editor A recent study assessed the noninferiority of IMRT alone vs concurrent chemoradiotherapy for treating low-risk NPC. The noninferiority claim was based on a 3-year failure-free survival rate with a noninferiority margin of 10% for the absolute failure-free survival rate (...)
• 01:00
  Graded Sensorimotor Retraining and Pain Intensity in Chronic Low Back Pain J Am Med Assoc (JAMA)
  To the Editor We have some concerns about the recent study that reported that graded sensorimotor retraining, compared with a sham procedure and attention control, significantly improved pain intensity among patients with low back (...)
• 01:00
  Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy and Survival of Patients With Low-Risk Nasopharyngeal Carcinoma—Reply J Am Med Assoc (JAMA)
  In Reply We agree with Ms Hu and Dr Kao that the current NCCN guidelines recommend definitive radiotherapy with or without concurrent chemotherapy for NPC with stage II and T3N0 disease, and in this subset, induction or adjuvant chemotherapy only for patients with high-risk features including (...)
• 01:00
  Graded Sensorimotor Retraining and Pain Intensity in Chronic Low Back Pain—Reply J Am Med Assoc (JAMA)
  In Reply The RESOLVE trial found that participants with chronic low back pain who received a graded sensorimotor retraining intervention reported significantly and clinically meaningfully improved pain intensity at 18-week follow-up compared with a sham procedure and attention control (...)
• 01:00
  High-Flow Oxygen vs Standard Oxygen Therapy on Length of Hospital Stay in Children J Am Med Assoc (JAMA)
  This randomized clinical trial compares the effect of early high-flow oxygen therapy vs standard oxygen therapy on length of hospital stay in children with acute hypoxemic respiratory failure.
• 01:00
  Association of Supernumerary Sex Chromosome Aneuploidies With Venous Thromboembolism J Am Med Assoc (JAMA)
  This study assesses the association of sex chromosome aneuploidies with incidence of venous thromboembolism (VTE) in 2 large biobank populations.
• 01:00
  Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Heart Failure J Am Med Assoc (JAMA)
  This clinical trial compares the efficacy of torsemide vs furosemide in decreasing the risk of death from any cause among patients hospitalized for heart failure (regardless of ejection fraction).
• 01:00
  Patient Information: Atopic Dermatitis (Eczema) J Am Med Assoc (JAMA)
  This JAMA Patient Page describes atopic dermatitis (eczema) and its symptoms and treatment options.
• 01:00
  How Was Clinic? J Am Med Assoc (JAMA)
  They reminded me of your parents but better dressed, my wife Jessica said as she described a patient and her husband she had seen in clinic that day—a patient with metastatic breast cancer on her way to hospice but still asking Jessica about her life and family— by which she meant, I think, that (...)
• 01:00
  Fake It ‘Til You Make It J Am Med Assoc (JAMA)
  In this narrative medicine essay, a medical student recounts the high price to their mental health for embracing the advice of their childhood therapist to “fake it ‘til you make it.”
• 01:00
  Surgical Site Infection Prevention—A Review J Am Med Assoc (JAMA)
  This review summarizes current evidence-based interventions for prevention of surgical site infection that are applicable to the majority of operations.
• 01:00
  JAMA J Am Med Assoc (JAMA)
• 01:00
  Anatomy From Nazi Germany to Today J Am Med Assoc (JAMA)
  This viewpoint reviews the anatomical body procurement used in Nazi Germany, notes the continued use of those images, and calls for disclosure of the biographical history of the people whose bodies and tissues are now studied.
• 01:00
  WHO Report: Cholera Resurgent in 2022 After Years of Decline J Am Med Assoc (JAMA)
  Cholera cases and cholera-associated deaths jumped globally in 2022 following years of decline, marking a resurgence of the ongoing seventh cholera pandemic, which began in 1961, according to a World Health Organization (WHO) (...)
• 01:00
  Increasing Antimicrobial Resistance Poses Global Threat, WHO Says J Am Med Assoc (JAMA)
  High levels of antimicrobial resistance are causing life-threatening bloodstream infections and increasing treatment resistance for several common bacterial infections, according to the World Health Organization (WHO).
• 01:00
  More Adolescents and Young Adults Developing Type 2 Diabetes Around the World J Am Med Assoc (JAMA)
  From 1990 through 2019, the incidence of type 2 diabetes among people aged 15 to 39 years jumped 56%, according to a survey of 204 countries published in The BMJ.
• 01:00
  The Need for a Smoking Cessation “Care Package” J Am Med Assoc (JAMA)
  This Viewpoint from leadership at the US Food and Drug Administration (FDA) proposes the creation of a comprehensive “care package” framework of resources to help maximize cessation of tobacco use, including components focused on strategies at the individual, health system, and population (...)
• 01:00
  Candida auris Outwits Treatments and Travels Incognito J Am Med Assoc (JAMA)
  This Medical News feature examines the relatively newly identified fungus Candida auris, a hardy species that can resist treatment with antifungal agents, is highly contagious, and is associated with serious infections and significant (...)
• 01:00
  Association Between Levonorgestrel Intrauterine Systems Dose and Subsequent Psychotropic Drugs Use J Am Med Assoc (JAMA)
  This matched-cohort study uses data from the French National Health Insurance database to assess whether a 19.5-mg levonorgestrel intrauterine system, vs a 52-mg system, is associated with increased use of antidepressant, hypnotic, and anxiolytic (...)
• 01:00
  A 62-Year-Old Woman With a Large Abdominal Mass J Am Med Assoc (JAMA)
  A 62-year-old nulligravida woman had 10 months of progressive abdominal distension, diffuse abdominal pain, and 25-kg weight gain. She had no nausea or vomiting, hematochezia, or stool changes; pelvic and abdominal examination showed a large abdominal mass extending from the epigastrium to the (...)
• 01:00
  Fifty Years of a National Program for the Treatment of Kidney Failure J Am Med Assoc (JAMA)
  This Viewpoint examines the first 50 years of the US End-Stage Renal Disease (ESRD) program, including technological updates and continuing challenges to update cost and quality.

10 January

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 01:00
  Narrative Insights Into Schizoaffective Disorder J Am Med Assoc (JAMA)
  This Arts and Medicine feature reviews The Collected Schizophrenias, a 2019 essay collection by Esmé Weijun Wang about her experiences living with schizoaffective disorder.
• 01:00
  Twenty-Strain “Universal” mRNA Flu Vaccine Effective in Animal Studies J Am Med Assoc (JAMA)
  An investigational messenger RNA (mRNA) vaccine encoding hemagglutinin antigens from all 20 known influenza A virus subtypes and B virus lineages protected mice and ferrets from a wide range of matched and mismatched virus strains in a recent (...)
• 01:00
  Noninvasive Sensory Stimulation With Light and Sound Tested in Alzheimer Disease J Am Med Assoc (JAMA)
  Two early clinical studies suggest that sensory stimulation with light and sound should be studied further for its potential to slow neurodegeneration and improve behavioral function in mild Alzheimer disease, according to a report in PLOS (...)
• 01:00
  Whole-Sporozoite Malaria Vaccine Candidate Shows Real-world Promise J Am Med Assoc (JAMA)
  An experimental malaria vaccine using whole, inactivated Plasmodium falciparum sporozoites reduced the risk of natural infection among adults in a malaria-endemic region, according to a report in Science Translational Medicine.
• 01:00
  Incorrect Author Name J Am Med Assoc (JAMA)
  The Original Investigation titled “Development of a Prediction Model for Ascending Aortic Diameter Among Asymptomatic Individuals,” published in the November 15, 2022, issue of JAMA, omitted master’s degrees for Drs Benjamin and Lubitz; also, the first and last names of byline author Ramachandran (...)
• 01:00
  Incorrect Wording J Am Med Assoc (JAMA)
  In the Editorial titled “Clinical Decision Support to Prevent Acute Kidney Injury After Cardiac Catheterization: Moving Beyond Process to Improving Clinical Outcomes,” published in the September 6, 2022, issue of JAMA, an incorrect term was used in several places. The phrase “intravenous contrast” (...)
• 01:00
  Incorrect Data, Investigator Name, and eFigure J Am Med Assoc (JAMA)
  In the Original Investigation titled “Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial,” published in the October 25, 2022, issue of JAMA, the number of participating sites was incorrect in the Abstract and (...)
• 01:00
  Home Sleep Apnea Testing for the Diagnosis of Obstructive Sleep Apnea J Am Med Assoc (JAMA)
  A 50-year-old patient with epilepsy, hypertension, loud snoring, recent 50-lb weight gain, and abrupt awakenings with a feeling of breathlessness but no headaches or excessive daytime sleepiness presented with concerns. What would you do (...)
• 01:00
  Catheter Ablation for Persistent Atrial Fibrillation J Am Med Assoc (JAMA)
  Compared with treatments for other cardiac arrhythmias, the treatment of atrial fibrillation (AF) has changed dramatically in the last 25 years. The landmark work of Haïssaguerre et al established the pulmonary veins as the initiation site of AF in the majority of cases and launched the era of (...)
• 01:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 01:00
  The Quest of Potential Energy J Am Med Assoc (JAMA)
  During the nineteenth century, the science of physiology learned the significance of the energy aspects of nutrition. As Lusk has recently reminded us anew, in a delightful review of the history of metabolism, Rubner was the first to solve the problem initiated by Lavoisier, of demonstrating (...)
• 01:00
  Hearing Loss and Dementia Prevalence in Older Adults in the US J Am Med Assoc (JAMA)
  This study assesses the association of audiometric hearing loss and hearing aid use with dementia among community-dwelling older US Medicare beneficiaries.
• 01:00
  Comparison of the Financial and Operational Characteristics of For-Profit and Nonprofit Hospitals Receiving Federal GME Payments, 2011-2020 J Am Med Assoc (JAMA)
  This study compares graduate medical education (GME) payments between nonprofit and for-profit hospitals between 2011 and 2020 to assess how hospitals value GME.
• 01:00
  Effect of an Individualized Audit and Feedback Intervention on Rates of Musculoskeletal Diagnostic Imaging Requests J Am Med Assoc (JAMA)
  To the Editor A recent study is one of a series of interventions by the Australian Department of Health and Aged Care intended to “nudge” Australian general practitioners (GPs) who are higher users of certain billing items, medicines, or investigations to reduce their use. We have several (...)
• 01:00
  Aspirin vs Enoxaparin and Symptomatic Venous Thromboembolism in Hip or Knee Arthroplasty J Am Med Assoc (JAMA)
  To the Editor We have some comments about the limitations of the CRISTAL trial, which evaluated the effect of aspirin vs enoxaparin on symptomatic VTE in patients undergoing hip or knee arthroplasty.
• 01:00
  Aspirin vs Enoxaparin and Symptomatic Venous Thromboembolism in Hip or Knee Arthroplasty J Am Med Assoc (JAMA)
  To the Editor We have some comments about the CRISTAL study, which investigated the effect of aspirin vs enoxaparin on symptomatic venous thromboembolism (VTE) in patients undergoing hip or knee arthroplasty.
• 01:00
  Aspirin vs Enoxaparin and Symptomatic Venous Thromboembolism in Hip or Knee Arthroplasty J Am Med Assoc (JAMA)
  To the Editor A recent study showed that aspirin, compared with enoxaparin, resulted in a significantly higher rate of symptomatic VTE within 90 days in patients undergoing hip or knee arthroplasty for osteoarthritis. Mortality from pulmonary embolism after hip and knee arthroplasty has (...)
• 01:00
  Effect of an Individualized Audit and Feedback Intervention on Rates of Musculoskeletal Diagnostic Imaging Requests—Reply J Am Med Assoc (JAMA)
  In Reply On behalf of the study team, we thank Dr Stone and colleagues for providing this opportunity to address several misconceptions about our study.
• 01:00
  Aspirin vs Enoxaparin and Symptomatic Venous Thromboembolism in Hip or Knee Arthroplasty—Reply J Am Med Assoc (JAMA)
  In Reply First, we would like to address some of the concerns about the issue of confounding from unmeasured variables (anesthesia type and postoperative rehabilitation) that was mentioned by Dr Chia-Chien Hsu and colleagues. Due to the randomized, crossover design of our study, each (...)
• 01:00
  Association Between Regulatory Submission Characteristics and Recalls of Medical Devices With 510(k) Clearance J Am Med Assoc (JAMA)
  This study uses US Food and Drug Administration data and examines the association between characteristics of predicate medical devices and recall probability for applicant medical devices cleared for use via the 510(k) regulatory submission (...)
• 01:00
  Use of Recalled Devices in FDA New Device Authorizations and Risk of Subsequent Recalls J Am Med Assoc (JAMA)
  This cross-sectional study evaluates the frequency of new devices receiving US Food and Drug Administration approval through its 510(k) pathway based on predicate devices that had been subject to a Class 1 recall.
• 01:00
  Pulmonary Vein Isolation With vs Without Posterior Left Atrial Wall Isolation for Persistent AF J Am Med Assoc (JAMA)
  This randomized clinical trial compares pulmonary vein isolation (PVI) vs PVI with posterior wall isolation for achieving freedom from atrial arrhythmia in adult patients with persistent atrial fibrillation undergoing first-time catheter ablation in Australia, the UK, and (...)
• 01:00
  I Wonder If You Get Points in Heaven for This J Am Med Assoc (JAMA)
  It’s just after 2 am
• 01:00
  A Review of Autism Spectrum Disorder J Am Med Assoc (JAMA)
  This review discusses current evidence on the diagnosis and management of autism spectrum disorder.
• 01:00
  JAMA J Am Med Assoc (JAMA)
• 01:00
  CDC to Expand Wastewater Testing for Poliovirus J Am Med Assoc (JAMA)
  The CDC announced it is expanding targeted wastewater testing for poliovirus to help identify communities that would benefit from polio vaccination campaigns.
• 01:00
  CDC Invests $3 Billion in Rebuilding US Public Health J Am Med Assoc (JAMA)
  The CDC has awarded $3.2 billion in grants to local and territorial public health agencies to strengthen US public health infrastructure and rebuild the national public health workforce.
• 01:00
  Getting Treated for COVID-19 Shouldn’t Be This Difficult J Am Med Assoc (JAMA)
  In this narrative medicine essay, a psychiatrist finds that the difficulties she had helping her parents obtain Paxlovid seemed a common experience among her colleagues, so she offers patients and the medical community suggestions on how to simplify the (...)
• 01:00
  Will the New CDC Opioid Prescribing Guidelines Help Correct the Course in Pain Care? J Am Med Assoc (JAMA)
  This Medical News article discusses the 2022 Clinical Practice Guideline for Prescribing Opioids for Pain, an update to widely criticized recommendations released by the CDC in 2016.
• 01:00
  Ensuring Clarity and Understandability of the FDA’s Breast Density Notifications for All Members of the Public J Am Med Assoc (JAMA)
  This Viewpoint discusses the use of breast density notifications to inform women with dense breast tissue of the potential need for supplemental cancer screening, as well as the need to ensure that such notifications are clear and understandable to women of all language backgrounds, literacy (...)
• 01:00
  Defending Racial and Ethnic Diversity in Undergraduate and Medical School Admission Policies J Am Med Assoc (JAMA)
  This Viewpoint argues that reversing or restricting the use of race and ethnicity in academic admission policies could also threaten the diversity of medical schools, both directly by restricting race consciousness in medical school admission practices and indirectly by reducing the overall (...)
• 01:00
  Patient Information: Fentanyl Overdose J Am Med Assoc (JAMA)
  This JAMA Patient Page describes fentanyl and illicit fentanyl analogues, and the common signs and symptoms of fentanyl overdose, its treatment, and overdose prevention measures.

3 January

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 01:00
  Long-term Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial J Am Med Assoc (JAMA)
  This secondary analysis of an ongoing adaptive platform trial examines the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes.
• 01:00
  Amid Ohio Measles Outbreak, New Global Report Warns of Decreased Vaccination During COVID-19 Pandemic J Am Med Assoc (JAMA)
  This Medical News article discusses an annual report on measles from the World Health Organization and the US Centers for Disease Control and Prevention.
• 01:00
  New JAMA Policy for Public Access to Scientific Research Findings and Principles of Biomedical Research J Am Med Assoc (JAMA)
  Timely access to scientific research findings for the broadest possible audience is a principle on which sound science is based. Access to new findings helps other scientists adjust their hypotheses and open new lines of inquiry, thereby supporting and accelerating further discovery and (...)
• 01:00
  Urgent Need for Next-Generation COVID-19 Vaccines J Am Med Assoc (JAMA)
  This Viewpoint argues that the development of a distinctly improved generation of SARS-CoV-2 vaccines is paramount to offering a greater breadth and depth of protection for a longer duration against COVID-19 disease.
• 01:00
  Medicaid, the Supreme Court, and Safe Care for Nursing Home Residents J Am Med Assoc (JAMA)
  This Viewpoint details the risk to Medicaid beneficiaries if the Supreme Court supports a decision that will allow states to deny benefits to eligible recipients and deny beneficiaries’ ability to hold states accountable in federal (...)
• 01:00
  Cardiovascular Corner—Researchers Probe Factors That May Contribute to Cardiovascular Health Disparities J Am Med Assoc (JAMA)
  This Medical News article highlights recently published research about disparities in cardiovascular health.
• 01:00
  Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults J Am Med Assoc (JAMA)
  This guideline from the International Antiviral (formerly AIDS) Society–USA updates practice recommendations for managing HIV infection, including when to change antiviral regimens; use of preexposure prophylaxis to prevent infection in at-risk persons; care of pregnant persons with HIV, people (...)
• 01:00
  COVID-19 and Excess All-Cause Mortality in the US and 20 Comparison Countries, June 2021-March 2022 J Am Med Assoc (JAMA)
  This study compares the COVID-19 per capita overall and excess mortality rates in the US vs rates for 20 Organization for Economic Co-operation and Development countries and the timing of any increases in excess mortality between June 2021 and December 2021 (Delta) and December 2021 to March (...)
• 01:00
  Patient Information: Pulmonary Embolism J Am Med Assoc (JAMA)
  This JAMA Patient Page describes pulmonary embolism signs and symptoms, risk factors, diagnosis, and treatment options.
• 01:00
  New Drug Delays Type 1 Diabetes Onset J Am Med Assoc (JAMA)
  Teplizumab-mzwv, a monoclonal antibody that delayed the onset of clinically diagnosed stage 3 type 1 diabetes by a median of about 2 years in clinical trials, gained FDA approval for patients aged 8 years or older with stage 2 (...)
• 01:00
  First FDA-Approved Gene Therapy for Hemophilia J Am Med Assoc (JAMA)
  The FDA granted its first approval for a gene therapy for hemophilia in late November.
• 01:00
  Combined COVID-19 and Flu Test Authorized for Point-of-Care Use J Am Med Assoc (JAMA)
  A multiplex molecular test that can detect SARS-CoV-2 variants of concern and both influenza A and B with a single nasal swab received Emergency Use Authorization from the FDA. Although this test is only for use in point-of-care settings, it’s a step toward development of multiplex home tests, (...)
• 01:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 01:00
  Low-Dose Aspirin Does Not Appear to Reduce Fractures J Am Med Assoc (JAMA)
  Daily low-dose aspirin does not appear to reduce risk of fractures—but may increase the risk of serious falls—among healthy older people living in the community, according to a substudy of the ASPREE (Aspirin in Reducing Events in the Elderly) clinical (...)
• 01:00
  Mindfulness Noninferior to Medication for Quelling Anxiety J Am Med Assoc (JAMA)
  A mindfulness intervention was as effective as first-line medication for patients with anxiety disorders in a recent trial published in JAMA Psychiatry.
• 01:00
  Vitamin C Improved Respiratory Health Among Children Born to Pregnant People Who Smoked J Am Med Assoc (JAMA)
  People who smoked during pregnancy and received vitamin C supplements gave birth to children with better airway function and a lower occurrence of wheeze at age 5 years than those who did not receive the vitamin, a recent clinical trial (...)
• 01:00
  Entirely Remote Intervention Decreased BP and LDL-C in Diverse Patient Groups J Am Med Assoc (JAMA)
  A completely remotely delivered hypertension and hypercholesterolemia program decreased blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) in a diverse racial and ethnic population of patients, including patients whose primary language was not (...)
• 01:00
  Present Status of “Insulin” J Am Med Assoc (JAMA)
  About one year ago it was announced that Banting and Best, working in the University of Toronto, had succeeded in isolating from the pancreas a substance capable of causing a marked reduction in the percentage of blood sugar and in the excretion of sugar in the urine of diabetic dogs. Since (...)
• 01:00
  Manufacturer Revenue on Inhalers After Expiration of Primary Patents, 2000-2021 J Am Med Assoc (JAMA)
  This study quantifies the revenue earned on all brand-name inhalers approved by the US Food and Drug Administration from 2000 to 2021 and compared earnings before and after expiration of primary patents on these products.
• 01:00
  Estimated Medicare Part B Savings From Inflationary Rebates J Am Med Assoc (JAMA)
  This study uses annual Medicare Part B spending data to examine the potential savings from the drug pricing reforms in the Inflation Reduction Act of 2022.
• 01:00
  Opportunities for Clinicians and Health Systems to Address Disparities in US Drug Overdose Deaths by Race and Ethnicity J Am Med Assoc (JAMA)
  To the Editor A recent Viewpoint on the increases in disparities in US drug overdose deaths by race and ethnicity called for “a multisectoral approach.” In addition to the solutions proposed, we think that universal access to medications for opioid use disorder (MOUD) during incarceration (...)
• 01:00
  Gout Flare and Cardiovascular Events J Am Med Assoc (JAMA)
  To the Editor A recent study reported that experiencing a recent gout flare was associated with subsequent cardiovascular events among individuals with gout. While these results are interesting, I am concerned that the authors did not control for use of low-dose aspirin, which is commonly (...)
• 01:00
  High- vs Low-Dose Tranexamic Acid Infusion and Need for Red Blood Cell Transfusion and Adverse Events in Cardiac Surgery J Am Med Assoc (JAMA)
  To the Editor A recent study demonstrated a modest but statistically significant reduction in the number of patients needing red blood cell transfusion with use of high-dose vs low-dose tranexamic acid.
• 01:00
  Opportunities for Clinicians and Health Systems to Address Disparities in US Drug Overdose Deaths by Race and Ethnicity—Reply J Am Med Assoc (JAMA)
  In Reply We thank Dr Kirkegaard and Ms Manaugh for raising the importance of expanding access to MOUD, especially among populations who are incarcerated and justice-involved. Expanding equitable access to MOUD is critical to address overdoses in these populations, given high rates of substance (...)
• 01:00
  Gout Flare and Cardiovascular Events—Reply J Am Med Assoc (JAMA)
  In Reply Dr Fonseca raises the issue of potential confounding by low-dose aspirin in our study of the association between gout flare and cardiovascular events. While we did not adjust for low-dose aspirin specifically, our multivariable model included adjustment for current (?60 days) or past (...)
• 01:00
  High- vs Low-Dose Tranexamic Acid Infusion and Need for Red Blood Cell Transfusion and Adverse Events in Cardiac Surgery—Reply J Am Med Assoc (JAMA)
  In Reply In response to the comments by Dr Koster and colleagues, the OPTIMAL trial enrolled patients aged 18 to 70 years, which is the age range of most patients undergoing adult cardiac bypass surgery in China. We agree that our study results, especially regarding seizures, should be (...)
• 01:00
  Remifentanil vs Neuromuscular Blockers and Intubation Without Major Complications Among Patients at Risk of Aspiration J Am Med Assoc (JAMA)
  This randomized trial assesses the effect of remifentanil vs neuromuscular blockers on successful intubation without major complications among patients at risk of aspiration during rapid sequence intubation in the operating room.
• 01:00
  Prescription of Antiretroviral Therapy Among People With HIV by Race and Ethnicity J Am Med Assoc (JAMA)
  This retrospective observational study of adults entering HIV care between 2007 and 2019 compares differences in the prescription of integrase inhibitor–containing antiretroviral therapy by patient race and ethnicity.
• 01:00
  Maine Medical Center J Am Med Assoc (JAMA)
  In the parking lot outside the hospital where my mother was rehabilitating from the fall, a group of men were standing around smoking cigars. This was Maine, autumn already hard in the air. At the center of the group, a man in hospital gown and a wheel- chair, smoking his own. Upstairs they (...)
• 01:00
  The Scent of Hope J Am Med Assoc (JAMA)
  In this narrative medicine essay, a neonatologist bends over her young daughter and breathes in the scent of hope after her child is hospitalized with diabetic ketoacidosis and a new diagnosis of diabetes.
• 01:00
  JAMA J Am Med Assoc (JAMA)
• 01:00
  Long-term Follow-up After Critical COVID-19 J Am Med Assoc (JAMA)
  The year 2020 was a grim and uncertain time for any clinician caring for inpatients with COVID-19, especially those with critical illness. In an era of modern medicine in which the range of options for many conditions can seem limitless, this novel viral threat was a reminder of the historical (...)
• 01:00
  RNA Sequencing as a Diagnostic Tool J Am Med Assoc (JAMA)
  This JAMA Insights discusses RNA sequencing, which allows detection of qualitative and quantitative changes in RNA expression across the genome in clinical samples, and how it may improve molecular diagnostic rates achieved by diagnostic exome sequencing and whole-genome sequencing (...)

27 December

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 01:00
  JAMA J Am Med Assoc (JAMA)
• 01:00
  Highest Rate of US Home Births in 3 Decades J Am Med Assoc (JAMA)
  The rate of home births in the US reached the highest level in 30 years in 2021, according to a National Vital Statistics report.
• 01:00
  Tobacco Use Remains High in Middle and High Schools J Am Med Assoc (JAMA)
  Nearly 1 in 9 US middle and high school students reported tobacco product use in the past 30 days—most commonly e-cigarettes—according to a CDC and US Food and Drug Administration analysis of data from the 2022 National Youth Tobacco Survey (NYTS). The researchers estimated that approximately (...)
• 01:00
  Target Trial Emulation for Causal Inference From Observational Data J Am Med Assoc (JAMA)
  This Guide to Statistics and Methods describes the use of target trial emulation to design an observational study so it preserves the advantages of a randomized clinical trial, points out the limitations of the method, and provides an example of its (...)
• 01:00
  Preapproved Promises to Voluntarily Withdraw FDA-Approved Drugs J Am Med Assoc (JAMA)
  This Viewpoint provides recommendations for improvements to strengthen legal obligations and decrease ambiguity for the US Food and Drug Administration regarding their reliance on voluntary preapproval withdrawal pledges.
• 01:00
  The FDA Struggle to Withdraw Makena J Am Med Assoc (JAMA)
  This Viewpoint discusses the controversy surrounding the FDA’s efforts to withdraw Makena from the market and the broader implications for the accelerated approval pathway.
• 01:00
  Data Sharing and the Growth of Medical Knowledge J Am Med Assoc (JAMA)
  In medical research, data sharing facilitates discovery and innovation, transparency, and reproducibility, and, ultimately, trust in science. Impelled by the COVID-19 pandemic, demands for data sharing have accelerated with increasing calls for more rapid dissemination, assessment, combination, (...)
• 01:00
  Physician-Legislators in Federal and State Government in 2022 J Am Med Assoc (JAMA)
  This study uses legislator data from a commercial data service firm database to characterize physicians serving in US federal and state legislatures in 2022 and to compare them with other legislators and with the US physician (...)
• 01:00
  Comparison of Industry Payments to Physicians and Advanced Practice Clinicians J Am Med Assoc (JAMA)
  This study uses Open Payments data to characterize and compare payments to physicians and advanced practice clinicians.
• 01:00
  Graphic Medicine—The Best of 2022 J Am Med Assoc (JAMA)
  This Arts and Medicine feature reviews 2 books published in 2022: a clinical ethics graphic medicine casebook illustrating how ethical dilemmas in clinical practice play out in real situations; and a graphic public health comics anthology showing how comics meet the needs of risk communication (...)
• 01:00
  The Relationship Between Income and Child Health J Am Med Assoc (JAMA)
  Researchers have been using statistical methods to investigate the link between health and income in both adults and children since individual-level data allowing them to do so first became available. However, previous investigators were forced to rely on highly imperfect data. Sample sizes (...)
• 01:00
  Restoring Physician Authority in an Era of Hospital Dominance J Am Med Assoc (JAMA)
  In this issue of JAMA, Ahmed et al report that approximately 1 in 10 health care workers are union members and that union membership is associated with higher wages, better benefits, and more equitable compensation across races and ethnicities. This analysis opens a new and timely avenue of (...)
• 01:00
  Surgeon General Tackles Workplace Well-being J Am Med Assoc (JAMA)
  US Surgeon General Vivek Murthy, MD, MBA, released framework for increasing mental health and well-being in the workplace.
• 01:00
  VA Finds Nirmatrelvir Associated With Lower Risk of Long Covid J Am Med Assoc (JAMA)
  The antiviral therapy nirmatrelvir, 1 of the medications used in Paxlovid, may mitigate the development of long COVID conditions, according to an observational study by the US Department of Veterans Affairs (VA). The study was posted to the preprint server medRxiv in early November and had not (...)
• 01:00
  HHS Releases New Report on Long COVID Experiences J Am Med Assoc (JAMA)
  The US Department of Health and Human Services (HHS) published a report highlighting the experiences of patients with long COVID. Between 5% and 30% of people who had COVID-19 may develop long COVID conditions, and about 1 million individuals aren’t in the workforce “at any given time” because of (...)
• 01:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 01:00
  A Plea For the Development of Pathology J Am Med Assoc (JAMA)
  Pathology, in its early development, was a by-product of anatomy during that period when the first dissections of the human body were developing anatomic knowledge. Morgagni, Vesalius, Fallopius, Eustachius, and others of the earlier anatomists, whose names are still attached to hydatids, tubes (...)
• 01:00
  Reported Health Care Affordability for US Men and Women With Employer-Sponsored Health Coverage J Am Med Assoc (JAMA)
  This study uses National Health Interview Survey data from 2000 to 2020 to examine reported differences between US men and women aged 19 to 64 years with employer-sponsored insurance in obtaining affordable health care.
• 01:00
  Stenting Plus Medical Therapy and Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis J Am Med Assoc (JAMA)
  To the Editor We have some observations about the CASSISS trial, which did not demonstrate superiority of intracranial stenting added to optimal medical therapy. This finding was similar to the SAMMPRIS and VISSIT trials.
• 01:00
  Stenting Plus Medical Therapy and Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis J Am Med Assoc (JAMA)
  To the Editor The recently published CASSISS trial was a prospective randomized study of intracranial artery stenting vs medical therapy for symptomatic intracranial atherosclerotic stenosis. The clinical outcomes of stroke and death in the stenting group at 1 year are similar to the WEAVE and (...)
• 01:00
  COVID-19 vs Influenza for Risk of Thrombotic Events in Hospitalized Patients J Am Med Assoc (JAMA)
  To the Editor We have several concerns about the recent study that demonstrated that hospitalization with COVID-19 before and during COVID-19 vaccine availability vs hospitalization with influenza in 2018-2019 was significantly associated with a higher risk of venous thromboembolism within 90 (...)
• 01:00
  Stenting Plus Medical Therapy and Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis—Reply J Am Med Assoc (JAMA)
  In Reply We agree with the comments by Drs Zedde and Pascarella and Drs Alexander and Yu that patient selection in our study may have altered the effect on the outcomes of stenting and medical therapy for patients with intracranial (...)
• 01:00
  COVID-19 vs Influenza for Risk of Thrombotic Events in Hospitalized Patients—Reply J Am Med Assoc (JAMA)
  In Reply We appreciate the interest in our recent study and the opportunity to share our responses to the comments by Dr Yii and colleagues. We sought to assess whether the risk of arterial and venous thromboembolism among patients hospitalized with COVID-19 differed from those hospitalized (...)
• 01:00
  JAMA Network Articles of the Year 2022 J Am Med Assoc (JAMA)
  This Medical News article is our annual roundup of the top-viewed articles from all JAMA Network journals.
• 01:00
  Angiotensin Receptor Blockers Not Effective Against COVID-19 J Am Med Assoc (JAMA)
  A pragmatic randomized clinical trial demonstrated that angiotensin receptor blockers (ARBs), widely used as an antihypertensive and used to treat individuals with a high risk of heart disease, did not improve clinical outcomes among people hospitalized with (...)
• 01:00
  Surgical Procedures for Ankle Osteoarthritis Produce Similar Results J Am Med Assoc (JAMA)
  Total ankle replacement and ankle fusion were equally effective for improving end-stage ankle osteoarthritis and had a similar number of harms, trialists reported in the Annals of Internal Medicine.
• 01:00
  Intensive Therapy Reduces Risks for Patients With Acute Heart Failure J Am Med Assoc (JAMA)
  Patients who were hospitalized for acute heart failure had a lower risk of all-cause death and heart failure readmission when they received early and rapid high-intensity medical therapy after discharge. The international STRONG-HF (Safety, Tolerability and Efficacy of Rapid Optimization, (...)
• 01:00
  Moderna COVID-19 Vaccine Safe and Effective for Children 6 Months to 5 Years J Am Med Assoc (JAMA)
  A trial found that two 25-?g doses of the mRNA-1273 (Moderna) vaccine were safe for children aged 6 months to 5 years and elicited immune responses consistent with those seen in older children, adolescents, and adults who had received higher doses of the (...)
• 01:00
  Association of Family Income With Morbidity and Mortality Among Lower-Income Children and Adolescents J Am Med Assoc (JAMA)
  This study examines the association between family income and the prevalence of claims-based diagnoses for 6 types of chronic and acute conditions, along with 10-year mortality, among children and adolescents in lower-income (...)
• 01:00
  Labor Unionization Among US Health Care Workers J Am Med Assoc (JAMA)
  This cross-sectional study examines the effect of unionization on pay, noncash benefit, and working hours among health care workers.
• 01:00
  Exome Sequencing of a Clinical Population for Autosomal Dominant Polycystic Kidney Disease J Am Med Assoc (JAMA)
  This retrospective study assesses the prevalence of autosomal dominant polycystic kidney disease and contributions of PKD1, PKD2, and other genes related to cystic kidney disease in a large, unselected cohort of patients.
• 01:00
  Patient Information: Amyotrophic Lateral Sclerosis J Am Med Assoc (JAMA)
  This JAMA Patient Page describes the neurological disorder amyotrophic lateral sclerosis and its symptoms, risk factors, diagnosis, and treatment options.
• 01:00
  In Extremis J Am Med Assoc (JAMA)
  father, two weeks before
• 01:00
  The Last Visit J Am Med Assoc (JAMA)
  In this narrative medicine essay, a hospice and palliative care social worker describes the expressions of love she and her mother shared in the last days of her mother’s life.
• 01:00
  Anxiety Disorders: A Review J Am Med Assoc (JAMA)
  This review summarizes current evidence on the diagnosis and treatment of generalized anxiety disorder, social anxiety disorder, and panic disorder with or without agoraphobia.

20 December

J Am Med Assoc (JAMA) https://jama.jamanetwork.com/

• 01:00
  Conservative Therapy for Acute and Subacute Back or Neck Pain J Am Med Assoc (JAMA)
  Among US adults, the estimated prevalence of low back pain is approximately 29% and the prevalence of neck pain is approximately 15%. Acute back pain typically resolves without treatment. Therefore, guidelines recommend education and advice to stay physically active as the primary therapeutic (...)
• 01:00
  Technological Tools to Improve Communication in Patients With Hearing Loss J Am Med Assoc (JAMA)
  The risk of hearing loss increases as the population ages, with approximately 23 million adults aged 70 years or older (63%) in the US having diminished speech perception. Although hearing loss is common in elderly people, management is largely ineffective due to several factors: poor (...)
• 01:00
  Some Naloxone Products Could Be Sold Without a Prescription J Am Med Assoc (JAMA)
  Certain naloxone products, which reverse opioid overdoses, could be safe and effective for over-the-counter use, according to a Federal Register? notice published recently by the FDA.
• 01:00
  Warning About Xylazine, a Veterinary Sedative Found in Illicit Drugs J Am Med Assoc (JAMA)
  Patients who don’t respond to naloxone may have overdosed on an opioid containing xylazine, a sedative and pain reliever approved for animals, not humans, the FDA recently cautioned.
• 01:00
  Illegal e-Cigarettes Targeting Youth J Am Med Assoc (JAMA)
  Five companies recently received FDA warning letters for selling illegal e-cigarettes designed to look like toys, food, and cartoon characters.
• 01:00
  Audio Highlights J Am Med Assoc (JAMA)
  Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
• 01:00
  Political Responsibility of the Physician J Am Med Assoc (JAMA)
  On various occasions heretofore the Journal has endeavored to impress upon the members of the medical profession the utility and need of their taking a more active part in the government of this country, both as regards National and municipal affairs. The subject is one, however, that is not (...)
• 01:00
  US Firearm-Related Deaths Among Children and Adolescents by Race and Ethnicity, 1999-2020 J Am Med Assoc (JAMA)
  This study assesses racial and ethnic differences in overall burden of firearm-related mortality and in change in firearm-related mortality among youths from 1999 to 2020.
• 01:00
  Association Between the 2021 Heat Wave in the Pacific Northwest and Emergency Department Visits J Am Med Assoc (JAMA)
  This study used a health care claims data set of enrollees in commercial and Medicare Advantage insurance plans to assess the association between the June 2021 heat wave and the rates of emergency department visits in Portland, Oregon, and Seattle, (...)
• 01:00
  Remote Ischemic Conditioning vs Usual Care and Neurologic Function in Acute Moderate Ischemic Stroke J Am Med Assoc (JAMA)
  To the Editor The Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke (RICAMIS) randomized clinical trial shed new light on remote ischemic conditioning (RIC) as a potential treatment in acute ischemic stroke, although there was a 5.4% absolute risk improvement in excellent outcome (...)
• 01:00
  Consent Laws for Minors Regarding Sexually Transmitted Infection and HIV Services J Am Med Assoc (JAMA)
  To the Editor The recent Research Letter about minor consent laws underscored a critical but poorly understood medicolegal concept: informed consent to medical treatment does not automatically confer confidentiality on the health information that is subsequently generated. State laws that (...)
• 01:00
  Remote Ischemic Conditioning vs Usual Care and Neurologic Function in Acute Moderate Ischemic Stroke—Reply J Am Med Assoc (JAMA)
  In Reply We appreciate the interest shown by Dr Pico and colleagues about our trial that investigated the effect of RIC on neurologic function in patients with acute moderate ischemic stroke. A dose-response relationship between the number of days of RIC (or the number of RICs delivered) and (...)
• 01:00
  Consent Laws for Minors Regarding Sexually Transmitted Infection and HIV Services—Reply J Am Med Assoc (JAMA)
  In Reply State laws that enable minors to consent independently to health care have important limitations, including those raised by Mr Kels. Minor consent regimes are complex and often require simultaneous application of multiple statutes, which makes the laws difficult to interpret and trust. (...)
• 01:00
  Community Health Worker–Delivered Hearing Care and Self-Perceived Communication Function in Older Adults J Am Med Assoc (JAMA)
  This randomized clinical trial assesses the effect of a community health worker–delivered personal sound amplification device intervention vs a wait-list control condition on self-perceived communication function at 3 months among older adults with hearing (...)
• 01:00
  Pessary vs Surgery in Treating Symptomatic Pelvic Organ Prolapse J Am Med Assoc (JAMA)
  This randomized clinical trial of adult women with stage 2 or greater pelvic organ prolapse compared the effects of treatment with surgery vs pessary.
• 01:00
  Effect of a Biopsychosocial Intervention or Postural Therapy on Disability and Health Care Spending in Spine Pain J Am Med Assoc (JAMA)
  This cluster randomized clinical trial compares the efficacy of 2 interventions that emphasize noninvasive care for spine pain vs usual care in reducing pain-related disability and health care spending among patients with acute or subacute spine (...)
• 01:00
  Bone Density Scan J Am Med Assoc (JAMA)
  You make flesh disappear, as death will do less gently; make me of mineral like the moon, waxing or waning.
• 01:00
  Physician-as-Patient—Vulnerabilities and Strengths J Am Med Assoc (JAMA)
  In this narrative medicine essay, a pediatric anesthesiologist explores the unique strengths of physicians facing serious illness along with sense of isolation they may also feel when they become patients.
• 01:00
  JAMA J Am Med Assoc (JAMA)
• 01:00
  Dogs May Reliably Detect SARS-CoV-2 Infections at Mass Events J Am Med Assoc (JAMA)
  Dogs trained to detect SARS-CoV-2 infection by smell correctly identified individuals with active infections at concerts with a specificity of nearly 100% and a sensitivity of 82%, researchers reported in BMJ Global Health. The results suggest that dogs may provide a fast and reliable screening (...)
• 01:00
  WHO: Vaccine Market Report Highlights Inequitable Global Distribution J Am Med Assoc (JAMA)
  Largely driven by COVID-19, vaccine doses distributed worldwide jumped to 16 billion in 2021, nearly 3 times the 5.8 billion in 2019, according to the World Health Organization (WHO) 2022 Global Vaccine Market Report. However, low- and middle-income countries (LMICs) often received (...)
• 01:00
  How Early COVID-19 Restrictions Effected Progress on Neglected Tropical Diseases J Am Med Assoc (JAMA)
  COVID-19 precautions taken in 2020 disrupted efforts to eliminate several neglected tropical diseases by 2030, which could delay some regions from reaching tropical disease control goals by 2 to 3 years in some cases, according to a modeling study. However, mitigation strategies could help (...)
• 01:00
  Wide Variation in Reported Type 1 Diabetes Incidence in Children Around the World J Am Med Assoc (JAMA)
  The reported incidence of type 1 diabetes from birth to 19 years varied more than 20-fold by region, with higher rates generally seen in higher-income countries, according to a scoping review published in PLOS Global Public Health.
• 01:00
  Guidelines for Reporting Outcomes in Trial Protocols J Am Med Assoc (JAMA)
  This report, the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT)–Outcomes 2022 extension, is a consensus statement on the standards for describing outcome-specific information in clinical trial protocols and contains recommendations to be integrated with the SPIRIT (...)
• 01:00
  Health and Safety Threats to Ukraine From Nonconventional Weapons J Am Med Assoc (JAMA)
  This Viewpoint discusses the potential for use of nonconventional warfare threats (chemical, biological, radiological, nuclear, and explosives) in the conflict in Ukraine and how health care professionals need to recognize and respond to these (...)
• 01:00
  Over-the-counter Hearing Aids: From Research to Policy to Practice J Am Med Assoc (JAMA)
  In this Viewpoint from officials at NIH and FDA, the authors discuss research collaborations between federal agencies and the private sector, using new regulations for over-the-counter hearing aids as an illustration.
• 01:00
  Telemedicine Rollbacks—Why Providing Care Across State Lines Is No Longer as Simple as It Was Early in the Pandemic J Am Med Assoc (JAMA)
  This Medical News feature examines how the expiration of states’ pandemic-related licensure waivers is limiting telemedicine services.
• 01:00
  Abdominal Pain in a 15-Year-Old Adolescent Girl J Am Med Assoc (JAMA)
  A 15-year-old adolescent girl taking an oral contraceptive had 3 days of pain in a 1-cm area of the lower left abdominal quadrant. She had no nausea/vomiting, diarrhea, hematochezia, bloating, or anorexia; no precipitating factors for the pain; and no history of pregnancy, abdominal surgery, or (...)
• 01:00
  Patient Information: Measles J Am Med Assoc (JAMA)
  This JAMA Patient Page describes measles infection, including prevention, symptoms of infection, contagiousness, and treatment.
• 01:00
  Selective Decontamination of the Digestive Tract—An Answer at Last? J Am Med Assoc (JAMA)
  Selective decontamination of the digestive tract (SDD) is one of the most controversial topics in the treatment of critically ill patients. With the first study published almost 40 years ago, 2 major new contributions appear in this issue of JAMA. Unfortunately, these new studies do not close (...)