5 July

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

• 13:14
  Association of Pulmonary Function With Late?Life Cardiac Function and Heart Failure Risk: The ARIC Study - Sergio H. R. Ramalho, Brian L. Claggett , George R. Washko , Raul San Jose Estepar , Patricia P. Chang , Dalane W. Kitzman , Gerson Cipriano Junior , Scott D. Solomon , Hicham Skali , and Amil M. Shah 1Division of Cardiovascular Medicine Brigham and Women’s Hospital Boston MA 2Health Sciences and Technologies Program – University of Brasilia Brasília Brazil 3Division of Pulmonary and Critical Care Medicine Brigham and Women’s Hospital Boston MA 4Department of Radiology Brigham and Women’s Hospital Boston MA 5University of North Carolina Chapel Hill NC 6Wake Forest School of Medicine (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundPulmonary and cardiac functions decline with age, but the associations of pulmonary dysfunction with cardiac function and heart failure (HF) risk in late life is not known. We aimed to determine the associations of percent (...) (Journal of the American Heart Association)
• 13:14
  Gravitational Dose?Response Curves for Acute Cardiovascular Hemodynamics and Autonomic Responses in a Tilt Paradigm - Richard S. Whittle, Nathan Keller , Eric A. Hall , Hrudayavani S. Vellore , Lindsay M. Stapleton , Katherine H. Findlay , Bonnie J. Dunbar , and Ana Diaz?Artiles 1Department of Aerospace Engineering Texas A&M University College Station TX 2Department of Health and Kinesiology Texas A&M University College Station TX 3Department of Biomedical Engineering Texas A&M University College Station TX 4Independent Researcher College Station TX J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundThe cardiovascular system is strongly dependent on the gravitational environment. Gravitational changes cause mechanical fluid shifts and, in turn, autonomic effectors influence systemic circulation and cardiac control. We (...) (Journal of the American Heart Association)
• 13:13
  Correction to: One?Month Dual Antiplatelet Therapy After Bioresorbable Polymer Everolimus?Eluting Stents in High Bleeding Risk Patients J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. (Journal of the American Heart Association)
• 13:12
  Correction to: Ischemic Stroke Severity and Mortality in Patients With and Without Atrial Fibrillation J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. (Journal of the American Heart Association)
• 13:12
  Correction to: Clinical Impact of Intraprocedural Stent Thrombosis During Percutaneous Coronary Intervention in Patients Treated With Potent P2Y12 inhibitors – a VALIDATE?SWEDEHEART Substudy J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. (Journal of the American Heart Association)

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Insights into basement membrane complexity - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 05 July 2022; doi:10.1038/s41581-022-00605-9Insights into basement membrane complexity (Nature Reviews Nephrology, Published online: 2022-07-05; | doi:10.1038/s41581-022-00605-9)
• 00:00
  A single-cell atlas of DKD treatment responses - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 05 July 2022; doi:10.1038/s41581-022-00603-xA single-cell atlas of DKD treatment responses (Nature Reviews Nephrology, Published online: 2022-07-05; | doi:10.1038/s41581-022-00603-x)
• 00:00
  Benefits of CoQ10 supplementation in patients with SRNS due to primary CoQ10 deficiency - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 05 July 2022; doi:10.1038/s41581-022-00604-wBenefits of CoQ10 supplementation in patients with SRNS due to primary CoQ10 deficiency (Nature Reviews Nephrology, Published online: 2022-07-05; | doi:10.1038/s41581-022-00604-w)
• 00:00
  Kidney xenotransplantation without acute rejection - Ellen F. Carney Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 05 July 2022; doi:10.1038/s41581-022-00602-yKidney xenotransplantation without acute rejection (Nature Reviews Nephrology, Published online: 2022-07-05; | doi:10.1038/s41581-022-00602-y)

4 July

J Human Hypertens http://www.nature.com/jhh/

• 00:00
  Correction to: Carotid elasticity is impaired in stage 1 hypertensive patients with well-controlled blood pressure levels - Francesca Saladini, Marcello Rattazzi, Elisabetta Faggin, Paolo Palatini, Massimo Puato J Human Hypertens
  Journal of Human Hypertension, Published online: 04 July 2022; doi:10.1038/s41371-022-00712-xCorrection to: Carotid elasticity is impaired in stage 1 hypertensive patients with well-controlled blood pressure levels (Journal of Human Hypertension, Published online: 2022-07-04; | doi:10.1038/s41371-022-00712-x)

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  The fibrogenic niche in kidney fibrosis: components and mechanisms - Li Li, Haiyan Fu, Youhua Liu Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 04 July 2022; doi:10.1038/s41581-022-00590-zThe fibrogenic niche is a unique tissue microenvironment that promotes fibroblast activation in organ fibrosis. This Review discusses the composition, function and mechanisms of action of the fibrogenic (...) (Nature Reviews Nephrology, Published online: 2022-07-04; | doi:10.1038/s41581-022-00590-z)

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

• 11:06
  Highlights in ASCVD Primary Prevention for 2021 - Tamar S. Polonsky, Amit Khera , Michael D. Miedema , Douglas D. Schocken , and Peter W. F. Wilson 1 Department of Medicine University of Chicago Medicine Chicago IL 2 Department of Medicine University of Texas, Southwestern Dallas TX 3 Allina Health Minneapolis MN 4 Department of Medicine Duke University Durham NC 5 Department of Medicine Emory University Atlanta GA J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. This review examines key studies published in 2021 that are related to primary prevention of atherosclerotic cardiovascular disease (ASCVD). Major randomized clinical trials (RCTs) concerning traditional risk factors or ASCVD events, (...) (Journal of the American Heart Association)

1 July

Stroke https://www.ahajournals.org/

• 11:00
  Targeted Plasma Proteomics to Predict the Development of Carotid Plaques - Andrea Baragetti Elisa Mattavelli Liliana Grigore Fabio Pellegatta Paolo Magni Alberico Luigi Catapano Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy (A.B., E.M., P.M., A.L.C.). IRCCS Multimedica, Milan, Italy (A.B., L.G., F.P., P.M., A.L.C.). S.I.S.A. Centre for the Study of Atherosclerosis, Bassini Hospital, Cinisello Balsamo, Milan, Italy (E.M.). Stroke
  Stroke, Ahead of Print. BACKGROUND:Cardiovascular risk stratification in primary prevention is a clinical challenge. We recently identified a large set of circulating proteins improving the risk prediction for cardiovascular events. We now evaluate which of these proteins predicts the (...) (Stroke)
• 11:00
  Advances in Remote Monitoring for Stroke Recovery - Janice J. Eng Amy M. Pastva Department of Physical Therapy, University of British Columbia and the Rehabilitation Research Program, GF Strong Rehabilitation Centre, Vancouver, Canada (J.J.E.). Division of Physical Therapy, Duke University and Duke Health Center for Interprofessional Education and Care, Durham, NC (A.M.P.). Stroke
  Stroke, Ahead of Print. (Stroke)

Circulation http://ahajournals.org/

• 11:00
  Trials and Tribulations of Randomized Clinical Trials - Robert A Harrington Medicine, Stanford University, UNITED STATES Circulation
  Circulation, Ahead of Print. (Circulation)
• 11:00
  High-Sensitivity Cardiac Troponin and the 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guidelines for the Evaluation and Diagnosis of Acute Chest Pain - Yader Sandoval Fred S. Apple Simon A. Mahler Richard Body Paul O. Collinson Allan S. Jaffe Departments of Cardiovascular Diseases, Mayo Clinic, Rochester, MN. (Y.S., A.S.J.) Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. (A.S.J.) Department of Laboratory Medicine and Pathology, Hennepin Healthcare/Hennepin County Medical Center and University of Minnesota, Minneapolis (F.S.A.). Department of Emergency Medicine, Wake Forest School of Medicine, Winston-Salem, NC (S.A.M.). Emergency Department, Manchester University NSH Foundation Trust, Manchester Academic Health Science (...) Circulation
  Circulation, Ahead of Print. The 2021 American Heart Association/American College of Cardiology/American Society of Echocardiography/American College of Chest Physicians/Society for Academic Emergency Medicine/Society of Cardiovascular Computed Tomography/Society for Cardiovascular Magnetic (...) (Circulation)

Kidney Int http://www.kidney-international.org/

• 00:00
  Molecular profiling of kidney compartments from serial biopsies differentiate treatment responders from non-responders in lupus nephritis. - Samir V. Parikh, Ana Malvar, Huijuan Song, John Shapiro, Juan Manuel Mejia-Vilet, Isabelle Ayoub, Salem Almaani, Sethu Madhavan, Valeria Alberton, Celeste Besso, Bruno Lococo, Anjali Satoskar, Jianying Zhang, Lianbo Yu, Paolo Fadda, Michael Eadon, Dan Birmingham, Latha P. Ganesan, Wael Jarjour, Brad H. Rovin Kidney Int
  The immune pathways that define treatment response and non-response in lupus nephritis (LN) are unknown. To characterize these intra-kidney pathways, transcriptomic analysis was done on protocol kidney biopsies obtained at flare (initial biopsy (Bx1)) and after treatment (second biopsy (Bx2)) (...) (Kidney International (2022))
• 00:00
  Indigenous peoples’ perspectives of living with chronic kidney disease: systematic review of qualitative studies - Marianne Kerr, Nicole Evangelidis, Penelope Abbott, Jonathan C. Craig, Michelle Dickson, Nicole Scholes-Robertson, Victoria Sinka, Rahim T. Vastani, Katherine Widders, Jacqueline Stephens, Allison Tong Kidney Int
  Indigenous Peoples are defined as those who first lived in a region and have distinct cultural traditions, knowledge and language which provides a basis for positive self-image and healthy identity.1 Indigenous Peoples have retained much of their cultural identity and displayed remarkable (...) (Kidney International (2022))
• 00:00
  Spatially resolved transcriptomics and the kidney: Many opportunities - Eryn E. Dixon, Haojia Wu, Elizabeth Sulvarán-Guel, Juanru Guo, Benjamin D. Humphreys Kidney Int
  Abstract: Defining changes in gene expression during health and disease is critical for the understanding of human physiology. In recent years, single cell/nuclei RNA sequencing (sc/snRNAseq) has revolutionized the definition and discovery of cell types and states, as well as the interpretation (...) (Kidney International (2022))

Am J Hypertens https://academic.oup.com/

• 02:00
  Value of Monocyte to High-Density Lipoprotein Cholesterol Ratio in Screening of Left Ventricular Hypertrophy in Young and Middle-Aged Patients With Essential Hypertension Am J Hypertens
  AbstractBackgroundTo investigate the relationships of monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) with left ventricular hypertrophy (LVH) in young and middle-aged patients with essential hypertension (EH).MethodsA retrospective analysis was performed on clinical data of (...)
• 02:00
  Detection Rate and Influencing Factors of Microalbuminuria in Hypertensive Patients Am J Hypertens
  AbstractBackgroundTo investigate the detection rate and relevant influencing factors of microalbuminuria (MAU) in hypertensive patients in China.MethodsA cross-sectional survey was conducted in 181,053 hypertensives from 600 hospitals across China. A questionnaire was used to collect (...)

J Human Hypertens http://www.nature.com/jhh/

• 00:00
  How to find and use validated blood pressure measuring devices - Dean S. Picone, Raj Padwal, George S. Stergiou, Jordana B. Cohen, Richard J. McManus, Siegfried Eckert, Kei Asayama, Neil Atkins, Michael Rakotz, Cintia Lombardi, Tammy M. Brady, James E. Sharman J Human Hypertens
  Journal of Human Hypertension, Published online: 01 July 2022; doi:10.1038/s41371-022-00718-5How to find and use validated blood pressure measuring devices (Journal of Human Hypertension, Published online: 2022-07-01; | doi:10.1038/s41371-022-00718-5)

Eur Heart J https://academic.oup.com/site_5375/

• 02:00
  The challenge of risk stratification in aortic aneurysms, congenital heart disease, and coronary bypass surgery Eur Heart J

J Hypertens http://journals.lww.com/jhypertension/

• 07:00
  Blood pressure management through application-based telehealth platforms: a systematic review and meta-analysis - Kalagara, Roshini; Chennareddy, Susmita; Scaggiante, Jacopo; Matsoukas, Stavros; Bhimani, Abhiraj; Smith, Colton; Putrino, David; Dangayach, Neha S.; Mocco, J.; Schnipper, Jeffrey L.; Auerbach, Andrew D.; Kellner, Christopher P. J Hypertens
  Background and objectives: Hypertension management has several challenges, including poor compliance with medications and patients being lost to follow-up. Recently, remote patient monitoring and telehealth technologies have emerged as promising methods of blood pressure management. We aimed to (...) -- REVIEWS
• 07:00
  Practical guide for the management of hypertensive disorders during pregnancy - Antza, Christina; Stabouli, Stella; Kotsis, Vasilios J Hypertens
  Hypertensive disorders of pregnancy, including gestational hypertension, preeclampsia, and eclampsia, are a worldwide health problem. Hypertensive disorders of pregnancy affect more than 10% of pregnancies and are associated with increased mortality and morbidity for both mother and fetus. (...) -- REVIEWS
• 07:00
  Arterial stiffness and renal function decline: are all stiffness measurements equally predictive? - Laurent, Stéphane J Hypertens
  No abstract available -- EDITORIAL COMMENTARIES
• 07:00
  Severe COVID-19 infection and cardiovascular disease – a long-term relationship or short myocardial affair? - Motwani, Manish J Hypertens
  No abstract available -- EDITORIAL COMMENTARIES
• 07:00
  Prevalence of hypertension and hypertension phenotypes after three visits in Chinese urban children - Dong, Jie; Dong, Hongbo; Yan, Yinkun; Cheng, Hong; Zhao, Xiaoyuan; Mi, Jie J Hypertens
  Objective: This study aims to evaluate the prevalence of hypertension and hypertension subtypes among Chinese children aged 6–17 years in a multicenter school-based sample by three separate screenings. Methods: Students from six major cities in China (Changchun, Beijing, Jinan, Shanghai, (...) -- ORIGINAL ARTICLES
• 07:00
  Cardiovascular outcome 6 months after severe coronavirus disease 2019 infection - Raafs, Anne G.; Ghossein, Mohammed A.; Brandt, Yentl; Henkens, Michiel T.H.M.; Kooi, M. Eline; Vernooy, Kevin; Spaanderman, Marc E.A.; Gerretsen, Suzanne; van Santen, Susanne; Driessen, Rob G.H.; Knackstedt, Christian; van der Horst, Iwan C.C.; van Bussel, Bas C.T.; Heymans, Stephane R.B.; Ghossein-Doha, Chahinda J Hypertens
  Objectives: In coronavirus disease 2019 (COVID-19), cardiovascular risk factors and myocardial injury relate to increased mortality. We evaluated the extent of cardiac sequelae 6 months after hospital discharge in patients surviving ICU hospitalization for COVID-19. Methods: All survivors of (...) -- ORIGINAL ARTICLES
• 07:00
  Epidemiology and outcomes of hypertensive crisis in patients with chronic kidney disease: a nationwide analysis - Pothuru, Suveenkrishna; Chan, Wan-Chi; Ranka, Sagar; Acharya, Prakash; Mehta, Harsh; Cannon, Chad; Yarlagadda, Sri G.; Shah, Zubair; Gupta, Kamal J Hypertens
  Background: The epidemiology and outcomes of hypertensive crisis (HTN-C) in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have not been well studied. The objective of our study is to describe the incidence, clinical characteristics, and outcomes of emergency (...) -- ORIGINAL ARTICLES
• 07:00
  Predictive ability of arterial stiffness parameters for renal function decline: a retrospective cohort study comparing cardio-ankle vascular index, pulse wave velocity and cardio-ankle vascular index0 - Nagayama, Daiji; Fujishiro, Kentaro; Miyoshi, Toru; Horinaka, Shigeo; Suzuki, Kenji; Shimizu, Kazuhiro; Saiki, Atsuhito; Shirai, Kohji J Hypertens
  Objective: The relative usefulness of arterial stiffness parameters on renal function remains controversial. This study aimed to compare the predictive ability of three arterial stiffness parameters at baseline; cardio-ankle vascular index (CAVI), heart–ankle pulse wave velocity (haPWV) and (...) -- ORIGINAL ARTICLES
• 07:00
  Transcriptomics of angiotensin II-induced long noncoding and coding RNAs in endothelial cells - Bu, Shuhan; Nguyen, Hien C.; Michels, David C.R.; Rasheed, Berk; Nikfarjam, Sepideh; Singh, Rohan; Wang, Lynn; Patel, Darshil A.; Singh, Shweta; Qadura, Mohammad; Singh, Krishna K. J Hypertens
  Objective: Angiotensin II (Ang II)-induced endothelial dysfunction plays an important role in the pathogenesis of cardiovascular diseases such as systemic hypertension, cardiac hypertrophy and atherosclerosis. Recently, long noncoding RNAs (lncRNAs) have been shown to play an essential role in (...) -- ORIGINAL ARTICLES
• 07:00
  Sirtuin1 inhibitor attenuates hypertension in spontaneously hypertensive rats: role of Gi? proteins and nitroxidative stress - Arifen, Nahida; Li, Yuan; Srivastava, Ashok K.; Anand-Srivastava, Madhu B. J Hypertens
  Background: We recently showed that vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHR) exhibit overexpression of Sirtuin1 (Sirt1) that contributes to the enhanced expression of Gi? proteins implicated in the development of hypertension in SHR. Method: The present (...) -- ORIGINAL ARTICLES
• 07:00
  Prevalence and associated factors of obstructive sleep apnea in refractory hypertension - Chedier, Bernardo; Roderjan, Christian N.; Cavalcanti, Aline H.; de Souza, Fabio; Muxfeldt, Elizabeth S. J Hypertens
  Background: Refractory hypertension (RfHT) and obstructive sleep apnea (OSA) share common pathophysiological mechanisms and probably are intrinsically associated, but their prevalence, clinical profile, and polysomnography (PSG) pattern remain misunderstood. Objective: To describe OSA (...) -- ORIGINAL ARTICLES
• 07:00
  Association of home and office systolic and diastolic hypertension with glucose metabolism in a general population: the Ohasama study - Tatsumi, Yukako; Satoh, Michihiro; Asayama, Kei; Murakami, Takahisa; Hirose, Takuo; Hara, Azusa; Tsubota-Utsugi, Megumi; Inoue, Ryusuke; Kikuya, Masahiro; Nomura, Kyoko; Metoki, Hirohito; Hozawa, Atsushi; Katagiri, Hideki; Imai, Yutaka; Ohkubo, Takayoshi J Hypertens
  Objective: This study was performed to investigate the association of hypertension subtypes with glucose metabolism among the Japanese general population. Methods: The study involved 646 residents (mean age: 62.4 years) without treatment for hypertension or a history of diabetes from Ohasama, a (...) -- ORIGINAL ARTICLES
• 07:00
  Association of ambulatory blood pressure with aortic valve and coronary artery calcification - Sawayama, Yuichi; Hisamatsu, Takashi; Kadota, Aya; Torii, Sayuki; Kondo, Keiko; Fujiyoshi, Akira; Higo, Yosuke; Harada, Akiko; Watanabe, Yoshiyuki; Nakagawa, Yoshihisa; Miura, Katsuyuki; Ueshima, Hirotsugu J Hypertens
  Objective: We aimed to investigate the effect of ambulatory blood pressure (BP) on aortic valve calcification (AVC) and coronary artery calcification (CAC), which are subclinical atherosclerotic diseases. Methods: In this population-based, cross-sectional study, we assessed office BP, mean (...) -- ORIGINAL ARTICLES
• 07:00
  Association of gestational hypertension and preeclampsia with nonsyndromic orofacial clefts in China: a large prospective cohort study - An, Hang; Jin, Ming; Li, Zhiwen; Zhang, Le; Zhang, Yali; Li, Hongtian; Liu, Jianmeng; Ye, Rongwei; Li, Nan J Hypertens
  Background: The associations between hypertensive disorders of pregnancy and nonsyndromic orofacial clefts (NSOFCs) are not consistent or based on case–control study design. We hypothesize that OFCs and NSOFCs are associated with hypertensive disease in pregnancy. Methods: Data were collected (...) -- ORIGINAL ARTICLES
• 07:00
  Lifestyle modification and cognitive function among individuals with resistant hypertension: cognitive outcomes from the TRIUMPH trial - Smith, Patrick J.; Sherwood, Andrew; Hinderliter, Alan L.; Mabe, Stephanie; Watkins, Lana L.; Craighead, Linda; Ingle, Krista; Tyson, Crystal; Avorgbedor, Forgive; Lin, Pao-Hwa; Kraus, William E.; Liao, Lawrence; Blumenthal, James A. J Hypertens
  Background: Resistant hypertension is associated with increased risk of cognitive decline, stroke, and dementia. Lifestyle modification has been suggested to improve cognitive function through its salutary effects on vascular function. Methods: Participants included 140 patients with resistant (...) -- ORIGINAL ARTICLES
• 07:00
  Disparities between determinants of impaired vascular structure and function in young people with primary hypertension: a systematic review - Azukaitis, Karolis; Sinha, Manish D.; Obrycki, ?ukasz; Pac, Micha?; Bjelakovic, Bojko; Jankauskiene, Augustina; Litwin, Mieczys?aw J Hypertens
  Objective: Early effects of primary hypertension on arterial structure and function in children and young people (CYP) and their determinants remain elusive. We aimed to review independent determinants of carotid intima–media thickness (cIMT), carotid wall cross-sectional area (WCSA) and (...) -- ORIGINAL ARTICLES
• 07:00
  Home blood pressure monitoring schedule: optimal and minimum based on 2122 individual participants’ data - Kyriakoulis, Konstantinos G.; Ntineri, Angeliki; Niiranen, Teemu J.; Lindroos, Annika; Jula, Antti; Schwartz, Claire; Kollias, Anastasios; Andreadis, Emmanuel A.; McManus, Richard J.; Stergiou, George S. J Hypertens
  Objectives: Home blood pressure (HBP) monitoring has become a primary method for hypertension diagnosis and management. This analysis aimed to investigate the optimal and minimum schedule for HBP monitoring. Methods: A retrospective analysis of cross-sectional data was performed, which involved (...) -- ORIGINAL ARTICLES
• 07:00
  Association between genetic risk of high SBP and hypertension control: the CoLaus|PsyColaus study - Marques-Vidal, Pedro; Chekanova, Valeriya; Vaucher, Julien J Hypertens
  Objective: To assess whether a genetic risk score (GRS) for high SBP is associated with poor control of hypertension. Methods: Data from the four waves of a population-based, prospective study conducted in Lausanne, Switzerland. Control of hypertension was defined based on SBP less than 140 (...) -- ORIGINAL ARTICLES
• 07:00
  Distinct transcriptomic profile of small arteries of hypertensive patients with chronic kidney disease identified miR-338-3p targeting GPX3 and PTPRS - Berillo, Olga; Huo, Ku-Geng; Richer, Chantal; Fraulob-Aquino, Júlio C.; Briet, Marie; Lipman, Mark L.; Sinnett, Daniel; Paradis, Pierre; Schiffrin, Ernesto L. J Hypertens
  Objective: Hypertension is associated with vascular injury, which contributes to end-organ damage. MicroRNAs regulating mRNAs have been shown to play a role in vascular injury in hypertensive mice. We aimed to identify differentially expressed microRNAs and their mRNA targets in small arteries (...) -- ORIGINAL ARTICLES
• 07:00
  Spot urinary sodium to monitor relative changes in population salt intake during the UK salt reduction programme - Tan, Monique; Wang, Changqiong; Song, Jing; He, Feng J.; MacGregor, Graham A. J Hypertens
  Objectives: The most accurate method to measure population salt intake is to collect the complete 24-h urinary sodium excretion (24-h UNa) but it is resource intensive and is rarely carried out frequently. We, therefore, assessed the use of spot urinary sodium concentration to monitor relative (...) -- ORIGINAL ARTICLES
• 07:00
  Barriers to up-titrated antihypertensive strategies in 12 sub-Saharan African countries: the Multination Evaluation of hypertension in Sub-Saharan Africa Study - Cavagna, Pauline; Kramoh, Kouadio Euloge; Diop, Ibrahima Bara; Kouam Kouam, Charles; Ikama, Meo Stéphane; Takombe, Jean Laurent; Damorou, Jean Marie; Ali Toure, Ibrahim; Balde, Dadhi M.; Dzudie, Anastase; Khoury, Stéphanie; Perier, Marie Cécile; Asselin, Anouk; Azizi, Michel; Houenassi, Martin Dèdonougbo; Kane, Abdoul; Kimbally-Kaki, Suzy Gisèle; Kingue, Samuel; Limbole, Emmanuel; Mfeukeu Kuate, Liliane; Mipinda, Jean Bruno; Ferreira, Beatriz; Nhavoto, Carol; Sidy Ali, Abdallahi; Empana, Jean Philippe; N’guetta, Roland; Jouven, Xavier; Antignac, (...) J Hypertens
  Background: Sub-Saharan Africa (SSA) faces the highest rate of hypertension worldwide. The high burden of elevated blood pressure (BP) in black people has been emphasized. Guidelines recommend two or more antihypertensive medications to achieve a BP control. We aimed to identify factors (...) -- ORIGINAL ARTICLES
• 07:00
  Role of the angiotensin type 1 receptor in modulating the carotid chemoreflex in an ovine model of renovascular hypertension - Sohn, Chris Sung-Eun; Chang, Joshua Wen-Han; George, Bindu; Chen, Siyi; Ramchandra, Rohit J Hypertens
  Objective: The carotid body has been implicated as an important mediator and putative target for hypertension. Previous studies have indicated an important role for angiotensin II in mediating carotid body function via angiotensin type-1 receptors (AT1R); however, their role in modulating (...) -- ORIGINAL ARTICLES
• 07:00
  Aortic root dilatation and aortic stiffness - Murakami, Tomoaki; Shiraishi, Masahiro; Niwa, Koichiro J Hypertens
  No abstract available -- CORRESPONDENCE
• 07:00
  The sex difference in the association of enhanced brachial–ankle pulse wave velocity and adverse cardiac remodeling: the possible background mechanism - Murakami, Tomoaki; Shiraishi, Masahiro J Hypertens
  No abstract available -- CORRESPONDENCE
• 07:00
  The interaction of estimated glomerular filtration rate with circadian blood pressure variation: do not forget the impact of albuminuria - Georgianos, Panagiotis I.; Vaios, Vasilios; Sgouropoulou, Vasiliki; Liakopoulos, Vassilios J Hypertens
  No abstract available -- CORRESPONDENCE

Current Opin Cardiol https://journals.lww.com/co-cardiology/

• 07:00
  Editorial introductions Current Opin Cardiol
  No abstract available -- EDITORIAL INTRODUCTIONS
• 07:00
  Electronic health strategies to improve medication adherence in patients with cardiometabolic disease: current status and future directions - Peacock, Erin; Craig, Leslie S.; Krousel-Wood, Marie Current Opin Cardiol
  Purpose of review Enabled by widespread technological advancements, electronic health (eHealth) strategies have expanded rapidly over the last decade, presenting opportunities to support self-management including medication adherence for cardiometabolic disease control. eHealth can minimize (...) -- HYPERTENSION: Edited by Hector O. Ventura and Carl J. Lavie
• 07:00
  New wrinkles in hypertension management 2022 - Carey, Robert M.; Whelton, Paul K. Current Opin Cardiol
  Purpose of review High blood pressure (BP) is the world's leading risk factor for cardiovascular disease (CVD) and death. This review highlights findings during the past 18 months that apply to the management of high BP in adults in the context of the 2017 American College of (...) -- HYPERTENSION: Edited by Hector O. Ventura and Carl J. Lavie
• 07:00
  Hypertension and cognitive function: a review of life-course factors and disparities - De Anda-Duran, Ileana; Woltz, Sara G.; Bell, Caryn N.; Bazzano, Lydia A. Current Opin Cardiol
  Purpose of review Dementia is a life-course condition with modifiable risk factors many from cardiovascular (CV) origin, and disproportionally affects some race/ethnic groups and underserved communities in the USA. Hypertension (HTN) is the most common preventable and treatable condition that (...) -- HYPERTENSION: Edited by Hector O. Ventura and Carl J. Lavie
• 07:00
  Editorial: the year in lipids and emerging risk factors - Mukherjee, Debabrata; Mikhailidis, Dimitri P. Current Opin Cardiol
  No abstract available -- LIPIDS AND EMERGING RISK FACTORS: Edited by Dimitri P. Mikhailidis and Debabrata Mukherjee
• 07:00
  Coronavirus disease 2019 and the cardiologist - Mohammad, Khan O.; Rodriguez, Jose B. Cruz; Urey, Marcus A. Current Opin Cardiol
  Purpose of review There continues to be extensive clinical and epidemiological data to suggest that coronavirus disease 2019 (COVID-19) infection is associated with numerous different types of cardiac involvement. Recent findings Myocardial injury has been reported in over 25% of patients (...) -- LIPIDS AND EMERGING RISK FACTORS: Edited by Dimitri P. Mikhailidis and Debabrata Mukherjee
• 07:00
  Diet and vascular risk - Gomez-Delgado, Francisco; Romero-Cabrera, Juan Luis; Perez-Martinez, Pablo Current Opin Cardiol
  Purpose of review The basis for the prevention and treatment of cardiovascular disease (CVD) inevitably involves lifestyle modification, including dietary pattern (DP). The aim of this review is to address the different models of healthy DP with their peculiarities and nutritional components as (...) -- LIPIDS AND EMERGING RISK FACTORS: Edited by Dimitri P. Mikhailidis and Debabrata Mukherjee
• 07:00
  Semaglutide for weight loss and cardiometabolic risk reduction in overweight/obesity - Mares, Adriana C.; Chatterjee, Saurav; Mukherjee, Debabrata Current Opin Cardiol
  Purpose of review Cardiovascular disease is the most common cause of morbidity and mortality worldwide, and the risk is heightened in the presence of obesity. We review semaglutide, a drug recently approved for chronic weight management in adults with obesity or who are overweight. Recent (...) -- LIPIDS AND EMERGING RISK FACTORS: Edited by Dimitri P. Mikhailidis and Debabrata Mukherjee
• 07:00
  N-3 polyunsaturated fatty acids for cardiovascular risk - Goff, Zackary D.; Nissen, Steven E. Current Opin Cardiol
  Purpose of review Use of omega-3 fatty acid (OM3FA) supplements to reduce risk of cardiovascular events has been investigated, largely without evidence of meaningful benefit, over the last 4 decades. Recent findings The first contemporary clinical trial to show benefit of OM3FA use was the (...) -- LIPIDS AND EMERGING RISK FACTORS: Edited by Dimitri P. Mikhailidis and Debabrata Mukherjee
• 07:00
  RNA interference-based therapies for the control of atherosclerosis risk factors - Kettunen, Sanna; Ruotsalainen, Anna-Kaisa; Ylä-Herttuala, Seppo Current Opin Cardiol
  Purpose of review Atherosclerosis, characterized by lipid accumulation and chronic inflammation in the arterial wall, is the leading causes of death worldwide. The purpose of this article is to review the status of RNA interference (RNAi) based therapies in clinical trials for the treatment and (...) -- LIPIDS AND EMERGING RISK FACTORS: Edited by Dimitri P. Mikhailidis and Debabrata Mukherjee
• 07:00
  Update on cancer therapy-induced atherosclerosis - Reeves, David J.; Rao, Vijay U. Current Opin Cardiol
  Purpose of review Recent advances in oncologic therapies have significantly improved overall survival for patients with malignancy. However, cardiovascular complications have not only increased in this population due to shared risk factors and pathophysiology, but also due to the therapies (...) -- LIPIDS AND EMERGING RISK FACTORS: Edited by Dimitri P. Mikhailidis and Debabrata Mukherjee
• 07:00
  What cardiologists should know about cardiac sarcoidosis in 2022? - Lemay, Sylvain; Marchand, Laurie; Sénéchal, Mario Current Opin Cardiol
  Purpose of review Cardiac sarcoidosis (CS) is a potentially fatal condition when unrecognized or not treated adequately. The purpose of this review is to provide new strategies to increase clinical recognition of CS and to present an updated overview of the immunosuppressive treatments using (...) -- LIPIDS AND EMERGING RISK FACTORS: Edited by Dimitri P. Mikhailidis and Debabrata Mukherjee

Lancet Diab Endocrinol https://www.thelancet.com/journals/landia/home

• 00:00
  [Series] Diagnosis of thyroid nodules - Erik K Alexander, Edmund S Cibas Lancet Diab Endocrinol
  Thyroid nodules are common, usually asymptomatic, and often pose minimal risk to the affected patient. However, 10–15% prove malignant and serve as the rationale for diagnostic assessment. Safely identifying and treating a relevant thyroid cancer through a cost-effective process is the primary (...) (The Lancet Diabetes & Endocrinology 10, 7 (2022))
• 00:00
  [Series] Management of thyroid nodules - Erik K Alexander, Gerard M Doherty, Justine A Barletta Lancet Diab Endocrinol
  In the past 30 years, there has been a substantial rise in the detection of thyroid nodules. Largely asymptomatic, thyroid nodules are most often incidental findings that typically pose minimal risk. Data supporting these findings show a rapid rise in the incidental detection of thyroid nodules (...) (The Lancet Diabetes & Endocrinology 10, 7 (2022))

Kidney Int http://www.kidney-international.org/

• 00:00
  The authors reply - Enric Vilar, Raja M. Kaja Kamal, James Fotheringham, Amanda Busby, Jocelyn Berdeprado, Ewa Kislowska, David Wellsted, Bassam Alchi, James O. Burton, Andrew Davenport, Ken Farrington Kidney Int
  We acknowledge the comments by Torreggiani et al.1 on our feasibility randomized controlled trial of incremental dialysis2 regarding the timing of initiating incremental dialysis. We randomized patients within 3 months of initiating hemodialysis rather than from day 1. The question is whether (...) (Kidney International 102, 1 (2022))
• 00:00
  In this issue Kidney Int
  Fabry disease results from a deficiency of the enzyme galactosidase-A (GLA), leading to accumulation of its substrates, primarily globotriaosylceramide (GL3) in various cells, including podocytes. As the disease is X-linked, males are severely affected, and all podocytes have the Fabry (...) (Kidney International 102, 1 (2022))
• 00:00
  Impact of APOL1 kidney risk variants on glomerular transcriptomes - Jeffrey B. Kopp, Jurgen Heymann Kidney Int
  McNulty and colleagues describe the glomerular transcriptional landscape of subjects with APOL1 (the gene encoding apolipoprotein L1)–associated kidney disease, using bulk RNA sequencing. They found the following: APOL1 gene expression was higher in individuals with APOL1 high-risk genetic (...) (Kidney International 102, 1 (2022))
• 00:00
  Journal Club Kidney Int
  Hung et al. (JAMA Intern Med. 2022;182:386–395.) (Kidney International 102, 1 (2022))
• 00:00
  Assessing prognosis in IgA nephropathy - Jürgen Floege, Stephanie Wied, Thomas Rauen Kidney Int
  Assessing the prognosis is essential in chronic diseases, such as IgA nephropathy. The 2021 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend the “International IgAN Prediction Tool” (available at www.qxmd.com) for this. The key limitation was that the tool was only validated (...) (Kidney International 102, 1 (2022))
• 00:00
  Room for improvement: diagnosing and managing acute coronary syndromes in persons with reduced eGFR - Kerry L. Horne, Maarten W. Taal, Nicholas M. Selby Kidney Int
  Cardiovascular events are the leading cause of death in chronic kidney disease. A recent analysis from the High-Sensitivity Troponin in the Evaluation of Patients With Suspected Acute Coronary Syndrome trial focused on results in those with reduced estimated glomerular filtration rate. This (...) (Kidney International 102, 1 (2022))
• 00:00
  James P. Knochel, MD, 1930–2022 Kidney Int
  The editorial board of Kidney International would like to express our heartfelt condolences to the family of Dr. James Knochel, who passed away on April 13, 2022, at the age of 91. Dr. Knochel served as an Associate Editor of Kidney International from 1984–2005. Dr. Knochel had a long and (...) (Kidney International 102, 1 (2022))
• 00:00
  The proliferative and the antifibrotic side of PAX2 in tubular repair - Oliver Wessely, Stuart J. Shankland Kidney Int
  Regenerative repair following injury to proximal tubular epithelial cells (PTECs) is essential to restore the kidney to normal function in acute kidney injury. Failure to accomplish this leads to chronic kidney disease. Expression of the paired-box transcription factor Pax2 in PTECs is required (...) (Kidney International 102, 1 (2022))
• 00:00
  A link between Krüppel-like factor 4, complement activation, and kidney damage - Diana Karpman, Sebastian Loos Kidney Int
  Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound (...) (Kidney International 102, 1 (2022))
• 00:00
  Are randomized trials the best way to test different dialysis initiation regimens? - Massimo Torreggiani, Antioco Fois, Hafedh Fessi, Giorgina Barbara Piccoli Kidney Int
  We read with interest the randomized controlled trial by Vilar et al., who compared standard thrice-weekly hemodialysis (sHD) with twice weekly dialysis (iHD) in patients initiating maintenance hemodialysis (MHD).1 (Kidney International 102, 1 (2022))
• 00:00
  Acute heart failure in a kidney transplant patient - Karim Jamhour-Chelh, María Melendo-Viu, David Dobarro, Sergio Raposeiras-Roubin, Inmaculada González-Bermúdez, Alberto Ortiz Sáez, Andrés Iñiguez-Romo Kidney Int
  A 62-year-old woman with a kidney transplant was admitted with a 3-week history of shortness of breath. On examination, she was noted to have a functioning upper limb arteriovenous fistula (AVF), enlargement of her left jugular vein (Figure 1a and b), decreased basal pulmonary breath sounds, (...) (Kidney International 102, 1 (2022))
• 00:00
  Armanni-Ebstein lesion in a diabetic patient with acute tubular injury - Geetha Jagannathan, Vadim A. Finkielstein, Glen S. Markowitz, Satoru Kudose Kidney Int
  A 45-year-old White woman with recently diagnosed type 2 diabetes mellitus and hypertension presented with acute kidney injury and septic shock with gram-positive bacteremia from a toe wound. She was treated with vancomycin and piperacillin-tazobactam followed by ertapenem. She had no exposure (...) (Kidney International 102, 1 (2022))
• 00:00
  Crystal-induced colitis - Andrea Spasiano, Federica Castri, Maria Cristina Giustiniani, Maria Elena Riccioni, Alessandro Naticchia, Giuseppe Grandaliano, Nicola Panocchia Kidney Int
  A 59-year-old man undergoing dialysis was admitted to our hospital with lower limb ischemia; he had a story of long-term use of phosphate and potassium chelator. Because of anemia and repeated episodes of bowel bleeding, he underwent colonoscopy with a biopsy of the ileocecal valve and (...) (Kidney International 102, 1 (2022))
• 00:00
  The Case | Inflammatory polyarthritis in a kidney transplant recipient - Karthikeyan Manoharan, Priyansh Gupta, Hitaishi Mehta, Ritambhra Nada, Aravind Sekar, Ashwani Kumar, Aman Sharma, Manish Rathi, Harbir Singh Kohli, Keshavamurthy Vinay, Raja Ramachandran Kidney Int
  A 52-year-old man underwent live donor kidney transplantation for end-stage kidney disease in 2001 (20 years post-transplant). His maintenance immunosuppressive therapy was tacrolimus, azathioprine, and prednisolone. He had chronic allograft dysfunction (serum creatinine level of 3 mg/dl). (...) (Kidney International 102, 1 (2022))
• 00:00
  Table of Contents Kidney Int
  (Kidney International 102, 1 (2022))
• 00:00
  Subscription Information Kidney Int
  (Kidney International 102, 1 (2022))
• 00:00
  Editorial Board Kidney Int
  (Kidney International 102, 1 (2022))
• 00:00
  Erratum to Kudose S, Lipton M, Jain NG, D’Agati VD. “Valproic acid–associated proximal tubulopathy.” Kidney Int. 2022;101:653 Kidney Int
  In the above-stated article, the sentence “Next generation sequencing of the mitochondrial genome failed to detect any pathogenic variants.” was not included in the third paragraph of the article, after the description of Figure 1b. Here is the paragraph with the sentence (...) (Kidney International 102, 1 (2022))

Diabetologia http://link.springer.com/

• 00:00
  Up Front Diabetologia
• 00:00
  Healthful eating patterns, serum metabolite profile and risk of diabetes in a population-based prospective study of US Hispanics/Latinos Diabetologia
  Abstract Aims/hypothesis We aimed to evaluate associations of multiple recommended dietary patterns (i.e. the alternate Mediterranean diet [aMED], the Healthy Eating Index [HEI]-2015 and the healthful Plant-based Diet Index [hPDI]) with serum metabolite profile, and to examine (...)
• 00:00
  Unravelling innervation of pancreatic islets Diabetologia
  Abstract The central and peripheral nervous systems play critical roles in regulating pancreatic islet function and glucose metabolism. Over the last century, in vitro and in vivo studies along with examination of human pancreas samples have revealed the structure of islet innervation, (...)
• 00:00
  Association of gut microbiota with glycaemic traits and incident type 2 diabetes, and modulation by habitual diet: a population-based longitudinal cohort study in Chinese adults Diabetologia
  Abstract Aims/hypothesis The gut microbiome is mainly shaped by diet, and varies across geographical regions. Little is known about the longitudinal association of gut microbiota with glycaemic control. We aimed to identify gut microbiota prospectively associated with glycaemic traits and type (...)

30 June

Stroke https://www.ahajournals.org/

• 11:00
  Digital Health–Enabled Clinical Trials in Stroke: Ready for Prime Time? - Otavio Berwanger M. Julia Machline-Carrion Academic Research Organization (ARO), Hospital Israelita Albert Einstein, São Paulo, Brazil (O.B.). Department of Medical Affairs, epHealth Primary Care Solutions, Florianópolis, Santa Catarina, Brazil (M.J.M.-C.). Stroke
  Stroke, Ahead of Print. As stroke continues to represent a major global health care problem, advancing our knowledge of new effective and safe stroke interventions represents a public health priority. The identification of these therapies requires the conduct of high-quality and well-powered (...) (Stroke)
• 11:00
  August Literature Synopsis - Macy E. Zardeneta Farida Sohrabji Department of Neuroscience and Experimental Therapeutics, Women’s Health in Neuroscience Program, Texas A&M University College of Medicine, Bryan. Stroke
  Stroke, Ahead of Print. (Stroke)
• 11:00
  Stenting and Angioplasty in Neurothrombectomy: Matched Analysis of Rescue Intracranial Stenting Versus Failed Thrombectomy - Mahmoud H. Mohammaden Diogo C. Haussen Alhamza R. Al-Bayati Ameer Hassan Wondwossen Tekle Johanna Fifi Stavros Matsoukas Okkes Kuybu Bradley A. Gross Michael J. Lang Sandra Narayanan Gustavo M. Cortez Ricardo A. Hanel Amin Aghaebrahim Eric Sauvageau Mudassir Farooqui Santiago Ortega-Gutierrez Cynthia Zevallos Milagros Galecio-Castillo Sunil A. Sheth Michael Nahhas Sergio Salazar-Marioni Thanh N. Nguyen Mohamad Abdalkader Piers Klein Muhammad Hafeez Peter Kan Omar Tanweer Ahmad Khaldi Hanzhou Li Mouhammad Jumaa Syed Zaidi Marion Oliver Mohamed M. Salem Jan-Karl Burkhardt Bryan A. Pukenas (...) Stroke
  Stroke, Ahead of Print. BACKGROUND:Successful reperfusion is one of the strongest predictors of functional outcomes after mechanical thrombectomy (MT). Despite continuous advancements in MT technology and techniques, reperfusion failure still occurs in ?15% to 30% of patients with large vessel (...) (Stroke)
• 11:00
  Amyloid-? (A?)-Related Cerebral Amyloid Angiopathy Causing Lobar Hemorrhage Decades After Childhood Neurosurgery - Jeremy F. Kellie Bruce C.V. Campbell Rosie Watson Adrian J. Praeger Girish Nair Anand Murugasu Christopher C. Rowe Colin L. Masters Steven Collins Catriona McLean Nawaf Yassi Departments of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, University of Melbourne, Australia (J.F.K., B.C.V.C., N.Y.). Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Australia (R.W., S.C.). Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Australia (R.W., N.Y.). Department of Neurosurgery, The Royal (...) Stroke
  Stroke, Ahead of Print. Background:Recent reports raise the possibility of cerebral amyloid angiopathy (CAA) leading to intracerebral hemorrhage in young adults following childhood neurosurgery, suggesting transmission of amyloid-? (A?) through neurosurgical procedures including dura mater (...) (Stroke)
• 11:00
  Serum L-Carnitine Levels Are Associated With First Stroke in Chinese Adults With Hypertension - Ziyi Zhou Nan Zhang Yun Song Lishun Liu Jianping Li Yan Zhang Yong Huo Xiangyi Liu Yong Duan Binyan Wang Hao Zhang Huiyuan Guo Xianhui Qin Xiaobin Wang Xiping Xu Tsinghua Shenzhen International Graduate School, Tsinghua University, China (Z.Z., L.L.). Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, Department of Nutrition and Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing (Z.Z., Y.S., L.L., H.Z., H.G., X.X.). Department of Cardiology, Peking University First Hospital, Beijing, China (N.Z., J.L., Y.Z., (...) Stroke
  Stroke, Ahead of Print. BACKGROUND:This study aimed to evaluate the association of serum L-carnitine with first stroke and explore potential effect modifiers.METHODS:This is a nested, case-control study drawn from the China Stroke Primary Prevention Trial among rural Chinese adults with (...) (Stroke)
• 11:00
  Single-Cell Transcriptome Analysis of the Circle of Willis in a Mouse Cerebral Aneurysm Model - Alejandra N. Martinez Giovane G. Tortelote Crissey L. Pascale Isabella G. McCormack Kristen D. Nordham Natalie J. Suder Mitchell W. Couldwell Aaron S. Dumont Department of Neurosurgery, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine, New Orleans, LA. (A.N.M., C.L.P., I.G.M., K.D.N., N.J.S., M.W.C., A.S.D.) Department of Pediatrics and The Tulane Hypertension & Renal Center of Excellence, Tulane University School of Medicine, New Orleans, LA. (...) Stroke
  Stroke, Ahead of Print. BACKGROUND:The circle of Willis (CoW) is the most common location for aneurysms to form in humans. Although the major cell types of the intracranial vasculature are well known, the heterogeneity and relative contributions of the different cells in healthy and aneurysmal (...) (Stroke)
• 11:00
  Normalization of Aperiodic Electrocorticography Components Indicates Fine Motor Recovery After Sensory Cortical Stroke in Mice - Jonatan Biskamp Sara Isla Cainzos Focko L. Higgen Christian Gerloff Tim Magnus Department of Neurology, University Medical Center Hamburg-Eppendorf, Germany. Stroke
  Stroke, Ahead of Print. BACKGROUND:Electrophysiological signatures of ischemic stroke might help to develop a deeper understanding of the mechanisms of recovery. However, to identify critical windows for novel treatment approaches, suitable readout parameters in vivo with the potential to close (...) (Stroke)

Hypertension https://www.ahajournals.org/

• 11:00
  Seasonal Variation in Day-by-Day Home Blood Pressure Variability and Effect on Cardiovascular Disease Incidence - Keisuke Narita Satoshi Hoshide Kazuomi Kario Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University School of Medicine, Tochigi, Japan. Hypertension
  Hypertension, Ahead of Print. Background:Although day-by-day home blood pressure (BP) variability (BPV) has been associated with cardiovascular disease (CVD) risk, it remains unclear whether this association differs from season to season. The present study aimed to assess seasonal variation in (...) (Hypertension)

Circulation http://ahajournals.org/

• 11:00
  Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab - Emil Hagström P. Gabriel Steg Michael Szarek Deepak L. Bhatt Vera A. Bittner Nicolas Danchin Rafael Diaz Shaun G. Goodman Robert A. Harrington J. Wouter Jukema Evangelos Liberopoulos Nikolaus Marx Jennifer McGinniss Garen Manvelian Robert Pordy Michel Scemama Harvey D. White Andreas M. Zeiher Gregory G. Schwartz Uppsala University, Department of Medical Sciences, and Uppsala Clinical Research Center, Sweden (E.H.). Department of Cardiology, Université de Paris, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, FACT (French Alliance for Cardiovascular Trials), and INSERM U1148, France (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein (...) (Circulation)

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

• 13:07
  Factors associated with uncontrolled blood pressure in hypertensive Brazilians - Thayza de Paula Araújo, Lucas Gabriel Sulino Borges, Weimar Kunz Sebba Barroso, Andrea Araújo Brandão, Eduardo Costa Duarte Barbosa, Audes Diógenes M Feitosa, Marcus Vinícius Bolivar Malachias, Marco Mota Gomes, Celso Amodeo, Rui Manoel dos Santos Povoa, Paulo César Brandão Veiga Jardim, Renato D. Lopes, Sandro Rogério Rodrigues Batista, Priscila Valverde de Oliveira Vitorino, the researchers of Study I RBH J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)

J Am Soc Nephrol https://jasn.asnjournals.org/

• 19:00
  Predicting Future Outcomes from Kidney Biopsies with MCD/FSGS Lesions: Opportunities and Limitations - Anders, H.-J., Boor, P. J Am Soc Nephrol
• 19:00
  Kidney Health Disparities: The Goal is Elimination - Wesson, D. E. J Am Soc Nephrol
• 19:00
  Equitable Transplantation: A Modifiable Risk Factor for Disparities in Mortality in ESKD - Laster, M., Norris, K. C. J Am Soc Nephrol
• 19:00
  Navigating to Kidney Health Equity - Griffith, D. M., Umeukeje, E. M. J Am Soc Nephrol
• 19:00
  United States Renal Data System Spotlight on Racial and Ethnic Health Equity: Progress, but Much Remains to Discover, Understand, and Improve - Johansen, K. L., Powe, N. R. J Am Soc Nephrol
• 19:00
  Looking Upstream-The Role of Primary Care in Addressing US Race Inequities in Kidney Health - Boulware, L. E. J Am Soc Nephrol
• 19:00
  Culturally Concordant Community-Health Workers: Building Sustainable Community-Based Interventions that Eliminate Kidney Health Disparities - Cervantes, L., Robinson, B. M., Steiner, J. F., Myaskovsky, L. J Am Soc Nephrol
• 19:00
  Recognizing the Potential Importance of Religion and Spirituality in the Care of Black Americans with Kidney Failure - Gelfand, S. L., Fitchett, G., Moss, A. H. J Am Soc Nephrol
• 19:00
  Racial and Ethnic Disparities in Home Dialysis Use in the United States: Barriers and Solutions - Rizzolo, K., Cervantes, L., Shen, J. I. J Am Soc Nephrol
• 19:00
  Lack of Cultural and Language Concordant Nutrition Education for Hispanic/Latinx Individuals with CKD: A Call to Action - Perez, L. M., Biruete, A. J Am Soc Nephrol
• 19:00
  Transplantation Mediates Much of the Racial Disparity in Survival from Childhood-Onset Kidney Failure - Becerra, A. Z., Chan, K. E., Eggers, P. W., Norton, J., Kimmel, P. L., Schulman, I. H., Mendley, S. R. J Am Soc Nephrol
  Background The role of kidney transplantation in differential survival in Black and White patients with childhood-onset kidney failure is unexplored. Methods We analyzed 30-year cohort data of children beginning RRT before 18 years of age between January 1980 and December 2017 (n=28,337) in (...)
• 19:00
  Maturation of GFR in Term-Born Neonates: An Individual Participant Data Meta-Analysis - Smeets, N. J. L., IntHout, J., van der Burgh, M. J. P., Schwartz, G. J., Schreuder, M. F., de Wildt, S. N. J Am Soc Nephrol
  Background The evidence from individual studies to support the maturational pattern of GFR in healthy, term-born neonates is inconclusive. We performed an individual participant data (IPD) meta-analysis of reported measured GFR (mGFR) data, aiming to establish neonatal GFR reference values. (...)
• 19:00
  A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection - Hassler, L., Wysocki, J., Gelarden, I., Sharma, I., Tomatsidou, A., Ye, M., Gula, H., Nicoleascu, V., Randall, G., Pshenychnyi, S., Khurram, N., Kanwar, Y., Missiakas, D., Henkin, J., Yeldandi, A., Batlle, D. J Am Soc Nephrol
  Background Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) uses full-length angiotensin converting enzyme 2 (ACE2) as a main receptor to enter target cells. The goal of this study was to demonstrate the preclinical efficacy of a novel soluble ACE2 protein with increased (...)
• 19:00
  Single-Cell Chromatin and Gene-Regulatory Dynamics of Mouse Nephron Progenitors - Hilliard, S., Tortelote, G., Liu, H., Chen, C.-H., El-Dahr, S. S. J Am Soc Nephrol
  Background We reasoned that unraveling the dynamic changes in accessibility of genomic regulatory elements and gene expression at single-cell resolution will inform the basic mechanisms of nephrogenesis. Methods We performed single-cell ATAC-seq and RNA-seq both individually (singleomes; (...)
• 19:00
  Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells - Schepelmann, M., Ranieri, M., Lopez-Fernandez, I., Webberley, T. S., Brennan, S. C., Yarova, P. L., Graca, J., Hanif, U.-K., Mu?ller, C., Manhardt, T., Salzmann, M., Quasnichka, H., Price, S. A., Ward, D. T., Gilbert, T., Matchkov, V. V., Fenton, R. A., Herberger, A., Hwong, J., Santa Maria, C., Tu, C.-L., Kallay, E., Valenti, G., Chang, W., Riccardi, D. J Am Soc Nephrol
  Background Impaired mineral ion metabolism is a hallmark of CKD–metabolic bone disorder. It can lead to pathologic vascular calcification and is associated with an increased risk of cardiovascular mortality. Loss of calcium-sensing receptor (CaSR) expression in vascular smooth muscle cells (...)
• 19:00
  Brief Early Life Angiotensin-Converting Enzyme Inhibition Offers Renoprotection in Sheep with a Solitary Functioning Kidney at 8 Months of Age - McArdle, Z., Singh, R. R., Bielefeldt-Ohmann, H., Moritz, K. M., Schreuder, M. F., Denton, K. M. J Am Soc Nephrol
  Background Children born with a solitary functioning kidney (SFK) are predisposed to develop hypertension and kidney injury. Glomerular hyperfiltration and hypertrophy contribute to the pathophysiology of kidney injury. Angiotensin-converting enzyme inhibition (ACEi) can mitigate (...)
• 19:00
  Aqp2+ Progenitor Cells Maintain and Repair Distal Renal Segments - Gao, C., Zhang, L., Chen, E., Zhang, W. J Am Soc Nephrol
  Background Adult progenitor cells presumably demonstrate clonogenicity, self-renewal, and multipotentiality, and can regenerate cells under various conditions. Definitive evidence demonstrating the existence of such progenitor cells in adult mammalian kidneys is lacking. Method We performed (...)
• 19:00
  The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia - Fritz, J., Brozek, W., Concin, H., Nagel, G., Kerschbaum, J., Lhotta, K., Ulmer, H., Zitt, E. J Am Soc Nephrol
  Background Insulin resistance, hypertension, hyperuricemia, and hypercholesterolemia are hypothesized to be important intermediates in the relationship between excess body weight and CKD risk. However, the magnitude of the total effect of excess body weight on ESKD mediated through these four (...)
• 19:00
  Association of Proximal Tubular Secretory Clearance with Long-Term Decline in Cognitive Function - Lidgard, B., Bansal, N., Zelnick, L. R., Hoofnagle, A., Chen, J., Colaizzo, D., Dobre, M., Mills, K. T., Porter, A. C., Rosas, S. E., Sarnak, M. J., Seliger, S., Sondheimer, J., Tamura, M. K., Yaffe, K., Kestenbaum, B., the CRIC Study Investigators, The CRIC Study Investigators, Appel, Cohen, Feldman, Go, Lash, Nelson, Rahman, Rao, Shah, Unruh J Am Soc Nephrol
  Background People with chronic kidney disease (CKD) are at high risk for cognitive impairment and progressive cognitive decline. Retention of protein-bound organic solutes that are normally removed by tubular secretion is hypothesized to contribute to cognitive impairment in CKD. Methods We (...)
• 19:00
  Hypomagnesemia, Hypocalcemia, and Tubulointerstitial Nephropathy Caused by Claudin-16 Autoantibodies - Figueres, L., Bruneau, S., Prot-Bertoye, C., Brideau, G., Neel, M., Griveau, C., Cheval, L., Bignon, Y., Dimitrov, J., Dejoie, T., Ville, S., Kandel-Aznar, C., Moreau, A., Houillier, P., Fakhouri, F. J Am Soc Nephrol
  Background Chronic hypomagnesemia is commonly due to diarrhea, alcoholism, and drugs. More rarely, it is caused by genetic defects in the effectors of renal magnesium reabsorption. Methods In an adult patient with acquired severe hypomagnesemia, hypocalcemia, tubulointerstitial nephropathy, (...)
• 19:00
  Kidney Biopsy Features Most Predictive of Clinical Outcomes in the Spectrum of Minimal Change Disease and Focal Segmental Glomerulosclerosis - Zee, J., Liu, Q., Smith, A. R., Hodgin, J. B., Rosenberg, A., Gillespie, B. W., Holzman, L. B., Barisoni, L., Mariani, L. H., for the Nephrotic Syndrome Study Network (NEPTUNE), The NEPTUNE Members, Adler, Alter, Athavale, Atkinson, Avila-Casado, Bagnasco, Baker, Barisoni, Bidot, Blake, Bray, Canetta, Chernitskiy, Cooper, Dell, Dell, Derebail, Desmond, Eddy, Fermin, Fervenza, Flynn, Fornoni, Froment, Gadegbeku, Gaut, Gibson, Gillespie, Gipson, Greenbaum, Hewitt, Hingorani, Hladunewich, Hodgin, Hogan, Holzman, Itteera, Jefferson, Kallem, Kaskel, Klida, Kretzler, Kopp, Kretzler, Kurtz, (...) J Am Soc Nephrol
  Background Heterogeneity in disease course and treatment response among patients with MCD/FSGS necessitates a granular evaluation of kidney tissue features. This study aimed to identify histologic and ultrastructural descriptors of structural changes most predictive of clinical outcomes in the (...)
• 19:00
  Calcium-Based Phosphate Binders and Plasma Oxalate Concentration in Dialysis Patients - Oka, Y., Miyazaki, M., Takatsu, S., Matsuda, H. J Am Soc Nephrol
• 19:00
  Clinical Studies of Vaccine Efficacy - Ashby, D. J Am Soc Nephrol
• 19:00
  Authors Reply: Calcium-Based Phosphate Binders and Plasma Oxalate Concentration in Dialysis Patients - Pfau, A., Knauf, F. J Am Soc Nephrol
• 19:00
  Authors Reply: Clinical Studies of Vaccine Efficacy - Bell, S., Campbell, J., Lambourg, E., Mark, P. J Am Soc Nephrol
• 19:00
  This Month's Highlights J Am Soc Nephrol
• 19:00
  GFR and eGFR in Term-Born Neonates - Filler, G., Sharma, A. P., Exantus, J. J Am Soc Nephrol
• 19:00
  Autoimmune Renal Calcium and Magnesium Wasting - Schlingmann, K. P., Konrad, M. J Am Soc Nephrol

Diabetologia http://link.springer.com/

• 00:00
  A genome-wide cross-trait analysis identifies shared loci and causal relationships of type 2 diabetes and glycaemic traits with polycystic ovary syndrome Diabetologia
  Abstract Aims/hypothesis The link underlying abnormal glucose metabolism, type 2 diabetes and polycystic ovary syndrome (PCOS) that is independent of BMI remains unclear in observational studies. We aimed to clarify this association using a genome-wide cross-trait approach. Methods Summary (...)
• 00:00
  Gut microbiota mediate melatonin signalling in association with type 2 diabetes Diabetologia
  Abstract Aims/hypothesis It has been shown that melatonin plays a general beneficial role in type 2 diabetes in rodents but its role in humans is controversial. In the present study, we investigated the association between serum melatonin and type 2 diabetes risk in a southern Chinese (...)

29 June

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

• 13:08
  Alcohol Consumption Is Associated With Postablation Recurrence but Not Changes in Atrial Substrate in Patients With Atrial Fibrillation: Insight from a High?Density Mapping Study - Yuichiro Sagawa, Yasutoshi Nagata , Naoyuki Miwa , Takanori Yamaguchi , Keita Watanabe , Masakazu Kaneko , Tomofumi Nakamura , Toshihiro Nozato , Takashi Ashikaga , Masahiko Goya , and Tetsuo Sasano 1 Department of Cardiology Japanese Red Cross Musashino Hospital Tokyo Japan 2 Cardiovascular Center Tsuchiura Kyodo Hospital Tsuchiura Japan 3 Department of Cardiovascular Medicine Saga University Saga Japan 4 Department of Cardiovascular Medicine Tokyo Medical and Dental University Tokyo (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundThe association between alcohol consumption, atrial substrate, and outcomes after atrial fibrillation (AF) ablation remains controversial. This study evaluated the impacts of drinking on left atrial substrate and AF recurrence (...) (Journal of the American Heart Association)
• 12:45
  Bidirectional Longitudinal Relationships Between Arterial Stiffness and Hypertension Are Independent of Those Between Arterial Stiffness and Diabetes: A Large?Scale Prospective Observational Study in Employees of a Japanese Company - Hiroki Nakano, Kazuki Shiina , Takamichi Takahashi , Masatsune Fujii , Yoichi Iwasaki , Chisa Matsumoto , Akira Yamashina , Taishiro Chikamori , and Hirofumi Tomiyama 1 Department of Cardiology Tokyo Medical University Tokyo Japan 2 Division of Preemptive Medicine for Vascular Damage Tokyo Medical University Tokyo Japan 3 Department of Nursing Kiryu University Gunma Japan J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundHypertension and diabetes frequently coexist; however, it has not yet been clarified if the bidirectional longitudinal relationships between arterial stiffness and hypertension are independent of those between arterial (...) (Journal of the American Heart Association)
• 12:45
  Impact of Managing Provider Type on Severe Aortic Stenosis Management and Mortality - Patricia A. Pellikka, Ratnasari Padang , Christopher G. Scott , Shannon M. E. Murphy , Rosalind Fabunmi , and Jeremy J. Thaden 1 Department of Cardiovascular Medicine Mayo Clinic Rochester MN 2 Department of Quantitative Health Sciences Mayo Clinic Rochester MN 3 Edwards Lifesciences Irvine CA J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundMany patients with symptomatic severe aortic stenosis do not undergo aortic valve replacement (AVR) despite clinical guidelines. This study analyzed the association of managing provider type with cardiac specialist follow?up, (...) (Journal of the American Heart Association)
• 12:45
  Novel Risk Prediction Model to Determine Adverse Heart Failure Outcomes in Arrhythmogenic Right Ventricular Cardiomyopathy - Shi Chen, Liang Chen , Ardan M. Saguner , Kai Chen , Deniz Akdis , Alessio Gasperetti , Corinna Brunckhorst , Hanwei Tang , Guangran Guo , Man Rao , Xiangjie Li , Jiangping Song , Firat Duru , and Shengshou Hu 1 State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China 2 University Heart Center Zurich Zurich Switzerland 3 Center for Integrative Human Physiology University of Zurich Zurich Switzerland 4 School of Statistics and Data Science Nankai University (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundPatients with arrhythmogenic right ventricular cardiomyopathy are at risk for life?threatening ventricular tachyarrhythmias, but progressive heart failure (HF) may occur in later stages of disease. This study aimed to (...) (Journal of the American Heart Association)
• 12:45
  Neuropeptide?Y Levels in ST?Segment–Elevation Myocardial Infarction: Relationship With Coronary Microvascular Function, Heart Failure, and Mortality - Thomas Gibbs, Nidi Tapoulal , Mayooran Shanmuganathan , Matthew K. Burrage , Alessandra Borlotti , Adrian P. Banning , Robin P. Choudhury , Stefan Neubauer , Rajesh K. Kharbanda , Vanessa M. Ferreira , Keith M. Channon , and Neil Herring 1 Department of Physiology, Anatomy and Genetics, Burdon Sanderson Cardiac Science Centre University of Oxford United Kingdom 2 Division of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence University of Oxford United Kingdom 3 Oxford Acute Vascular Imaging Centre University of Oxford United (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundThe sympathetic cotransmitter, neuropeptide Y (NPY), is released into the coronary sinus during ST?segment–elevation myocardial infarction and can constrict the coronary microvasculature. We sought to establish whether (...) (Journal of the American Heart Association)
• 12:44
  Inhibiting Succinate Release Worsens Cardiac Reperfusion Injury by Enhancing Mitochondrial Reactive Oxygen Species Generation - Alexander S. Milliken, Sergiy M. Nadtochiy , and Paul S. Brookes 1 Department of Pharmacology and Physiology University of Rochester Medical Center Rochester NY 2 Department of Anesthesiology and Perioperative Medicine University of Rochester Medical Center Rochester NY J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundThe metabolite succinate accumulates during cardiac ischemia. Within 5 minutes of reperfusion, succinate returns to baseline levels via both its release from cells and oxidation by mitochondrial complex II. The latter drives (...) (Journal of the American Heart Association)
• 12:44
  B?Type Natriuretic Peptide and Long?Term Cardiovascular Mortality in Patients With Coronary Heart Disease - Ralph A. H. Stewart, Adrienne Kirby , Harvey D. White , Simone L. Marschner , Malcolm West , Peter L. Thompson , David Sullivan , Edward Janus , David Hunt , Leonard Kritharides , Anthony Keech , John Simes , and Andrew M. Tonkin 1 Green Lane Cardiovascular Service Auckland City Hospital Auckland New Zealand 2 National Health and Medical Research Council Clinical Trials Centre University of Sydney Camperdown Australia 3 Department of Medicine University of Queensland Brisbane Australia 4 School of Population Health University of Western Australia Perth Australia 5 Department of Clinical (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundThe plasma concentration of B?type natriuretic peptide (BNP) is a strong predictor of adverse cardiovascular events. The aim of this study was to determine whether the association between plasma BNP concentration and (...) (Journal of the American Heart Association)
• 12:44
  Utility of Updated Japanese Circulation Society Guidelines to Diagnose Isolated Cardiac Sarcoidosis - Kimi Sato, Naoto Kawamatsu , Masayoshi Yamamoto , Tomoko Machino?Ohtsuka , Tomoko Ishizu , and Masaki Ieda 1 Department of Cardiology, Faculty of Medicine University of Tsukuba Japan J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundIn the population with cardiac sarcoidosis (CS), approximately one third lacks extracardiac involvement and is considered to have isolated CS. Recently, the Japanese Circulation Society updated the diagnostic criteria for CS, (...) (Journal of the American Heart Association)
• 12:44
  Left Ventricular Diastolic Dysfunction and Progression of Chronic Kidney Disease: Analysis of KNOW?CKD Data - Eunjeong Kang, Sung Woo Lee , Hyunjin Ryu , Minjung Kang , Seonmi Kim , Sue K. Park , Ji Yong Jung , Kyu?Beck Lee , Seung Hyeok Han , Curie Ahn , and Kook?Hwan Oh 1 Department of Internal Medicine Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine Seoul South Korea 2 Department of Internal Medicine Uijeongbu Eulji University Medical Center, Uijeongbu?si Gyeonggi?do South Korea 3 Department of Internal Medicine Seoul National University College of Medicine Seoul South Korea 4 Department of Preventive Medicine Seoul National University College of Medicine (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundFew studies have examined the association between the early diastolic mitral inflow velocity/early diastolic mitral annulus velocity ratio (E/e’) and chronic kidney disease progression.Methods and ResultsWe reviewed data from (...) (Journal of the American Heart Association)
• 12:44
  Comparison of Echocardiographic Changes Between Surgery and Medication Treatment in Patients With Primary Aldosteronism - Tomomi Ueda, Yuya Tsurutani , Jun Osada , Kosuke Inoue , Yoshitomo Hoshino , Masato Ono , Kazuki Nakai , Jun Saito , Kazuhiko Yumoto , and Tetsuo Nishikawa 1 Endocrinology and Diabetes Center Yokohama Rosai Hospital Yokohama Japan 2 Department of Cardiovascular Medicine Yokohama Rosai Hospital Yokohama Japan 3 Department of Social Epidemiology, Graduate School of Medicine Kyoto University Kyoto Japan 4 Nishikawa Clinic Yokohama Japan J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundPrimary aldosteronism can cause cardiac dysfunction, including left ventricular hypertrophy, left ventricular diastolic dysfunction, and left atrial enlargement. A few studies have compared the cardioprotective effects between (...) (Journal of the American Heart Association)
• 12:44
  Late Outcomes of Patients With Prehospital ST?Segment Elevation and Appropriate Cardiac Catheterization Laboratory Nonactivation - Amir Faour, Reece Pahn , Callum Cherrett , Oliver Gibbs , Karen Lintern , Christian J. Mussap , Rohan Rajaratnam , Dominic Y. Leung , David A. Taylor , Steven C. Faddy , Sidney Lo , Craig P. Juergens , and John K. French 1 Department of Cardiology, Liverpool Hospital Sydney New South Wales 2 The University of New South Wales Sydney New South Wales 3 Western Sydney University Sydney New South Wales 4 Ingham Institute Sydney New South Wales 5 New South Wales Ambulance Sydney New South (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundPatients with suspected ST?segment–elevation myocardial infarction (STEMI) and cardiac catheterization laboratory nonactivation (CCL?NA) or cancellation have reportedly similar crude and higher adjusted risks of death compared (...) (Journal of the American Heart Association)
• 12:44
  Diastolic Filling Time, Chronotropic Response, and Exercise Capacity in Heart Failure and Preserved Ejection Fraction With Sinus Rhythm - Kazuki Kagami, Masaru Obokata , Tomonari Harada , Toshimitsu Kato , Naoki Wada , Takeshi Adachi , and Hideki Ishii 1 Department of Cardiovascular Medicine Gunma University Graduate School of Medicine Maebashi Gunma Japan 2 Division of Cardiovascular Medicine National Defense Medical College Tokorozawa, Saitama Japan 3 Department of Rehabilitation Medicine Gunma University Graduate School of Medicine Maebashi Gunma Japan J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundExercise?induced high heart rate may impair exercise tolerance by reducing diastolic filling time and ventricular filling in heart failure with preserved ejection fraction (HFpEF). Given the importance of chronotropic response, (...) (Journal of the American Heart Association)
• 12:43
  Predicting Heart Failure in Arrhythmogenic Right Ventricular Cardiomyopathy - Weijia Wang, and Hugh Calkins 1 Division of Cardiology, Department of Medicine Johns Hopkins University Baltimore MD J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. (Journal of the American Heart Association)
• 12:43
  Association Between High?Sensitivity C?Reactive Protein and Prognosis in Different Periods After Ischemic Stroke or Transient Ischemic Attack - Yu Wang, Jiejie Li , Yuesong Pan , Mengxing Wang , Xia Meng , and Yongjun Wang 1 Department of Neurology Beijing Tiantan Hospital, Capital Medical University Beijing China 2 China National Clinical Research Center for Neurological Diseases Beijing China 3 Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical Sciences Beijing China J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundThe aim of this study was to investigate the association between hsCRP (high?sensitivity C?reactive protein) and prognosis over time after stroke onset.Methods and ResultsIn this prespecified prospective substudy of the Third (...) (Journal of the American Heart Association)
• 12:43
  Translating Clinical Guidelines Into Care Delivery Innovation: The Importance of Rigorous Methods for Generating Evidence - Adam N. Berman, and Jason H. Wasfy 1 Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital Harvard Medical School Boston MA 2 Cardiology Division, Department of Medicine, Massachusetts General Hospital Harvard Medical School Boston MA J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. (Journal of the American Heart Association)
• 12:43
  Misdiagnosis of Thoracic Aortic Emergencies Occurs Frequently Among Transfers to Aortic Referral Centers: An Analysis of Over 3700 Patients - George J. Arnaoutakis, Takuya Ogami , Edgar Aranda?Michel , Yancheng Dai , Reed Holmes , Thomas M. Beaver , Derek Serna?Gallegos , Tomas D. Martin , Forozan Navid , Sarah Yousef , and Ibrahim Sultan 1 University of Florida Health Gainsville FL 2 Division of Cardiac Surgery, Department of Cardiothoracic Surgery University of Pittsburgh Pittsburgh PA USA 3 Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh PA J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundAcute aortic syndromes may be prone to misdiagnosis by nonreferral aortic centers with less diagnostic experience. We evaluated regional variability in these misdiagnosis trends among patients transferred to different regional (...) (Journal of the American Heart Association)
• 12:42
  Sex?Specific Differences in Endothelial Function Are Driven by Divergent Mitochondrial Ca2+ Handling - Celio Damacena de Angelis, Benney T. Endoni , Daniel Nuno , Kathryn Lamping , Johannes Ledolter , Olha M. Koval , and Isabella M. Grumbach 1 Department of Internal Medicine, Abboud Cardiovascular Research Center University of Iowa Iowa City IA 2 Department of Pharmacology Carver College of Medicine University of Iowa Iowa City IA 3 Tippie College of Business University of Iowa Iowa City IA 4 College of Liberal Arts and Sciences University of Iowa Iowa City IA 5 Redox and Radiation Biology Program Holden Comprehensive Cancer Center University of Iowa Iowa City IA 6 Iowa City VA Healthcare (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundSex?specific differences in vasodilation are mediated in part by differences in cytosolic Ca2+handling, but how variations in mitochondrial Ca2+contributes to this effect remains unknown. Here, we investigated the extent to (...) (Journal of the American Heart Association)
• 12:42
  Survival Probability and Survival Benefit Associated With Primary Prevention Implantable Cardioverter?Defibrillator Generator Changes - Kenneth C. Bilchick, Yongfei Wang , Jeptha P. Curtis , Ramin Shadman , Todd F. Dardas , Inder Anand , Lars H. Lund , Ulf Dahlström , Ulrik Sartipy , and Wayne C. Levy 1 Department of Medicine University of Virginia Health System Charlottesville VA 2 Center for Outcomes Research and Evaluation Yale?New Haven Hospital New Haven CT 3 Department of Internal Medicine Yale University New Haven CT 4 Southern California Permanente Medical Group Los Angeles CT 5 Department of Medicine University of Washington Seattle WA 6 University of Minnesota Minneapolis MN 7 Department of Medicine/Cardiology (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundAs patients derive variable benefit from generator changes (GCs) of implantable cardioverter?defibrillators (ICDs) with an original primary prevention (PP) indication, better predictors of outcomes are needed.Methods and (...) (Journal of the American Heart Association)
• 12:41
  Colchicine Ameliorates Dilated Cardiomyopathy Via SIRT2?Mediated Suppression of NLRP3 Inflammasome Activation - Xuan Sun, Junfeng Duan , Chenyi Gong , Yuting Feng , Jiaxin Hu , Rong Gu , and Biao Xu 1 State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital Medical School of Nanjing University Nanjing China J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundDilated cardiomyopathy remains a leading cause of heart failure worldwide. Immune inflammation response is recognized as a significant player in the progression of heart failure; however, immunomodulatory strategies remain a (...) (Journal of the American Heart Association)
• 12:40
  Hospital?Level Variation in Ticagrelor Use in Patients With Acute Coronary Syndrome - Aya F. Ozaki, Cynthia A. Jackevicius , Alice Chong , Maneesh Sud , Jiming Fang , Peter C. Austin , and Dennis T. Ko 1School of Pharmacy & Pharmaceutical Sciences University of California Irvine CA United States 2College of Pharmacy Western University of Health Sciences Pomona CA United States 3Veterans Affairs Greater Los Angeles Healthcare System Los Angeles CA United States 4ICES Toronto Canada 5University of Toronto Ontario Canada 6Schulich Heart Centre Sunnybrook Health Sciences Centre Toronto Ontario (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundDespite improved outcomes associated with ticagrelor compared with clopidogrel in acute coronary syndrome (ACS), many studies have demonstrated slow adoption of ticagrelor in the United States because of its increased cost. (...) (Journal of the American Heart Association)
• 12:40
  Patent Ductus Arteriosus Stent Versus Surgical Aortopulmonary Shunt for Initial Palliation of Cyanotic Congenital Heart Disease with Ductal?Dependent Pulmonary Blood Flow: A Systematic Review and Meta?Analysis - Stephanie Y. Tseng, Vien T. Truong , Daniel Peck , Sneha Kandi , Samuel Brayer , Don P. Jason , Wojciech Mazur , Garick D. Hill , Awais Ashfaq , Bryan H. Goldstein , and Tarek Alsaied 1 The Heart Center Nationwide Children’s Hospital Columbus OH 2 The Heart Institute, Cincinnati Children’s Hospital Medical Center Cincinnati OH 3 The Christ Hospital Health Network Cincinnati OH 4 Northeast Ohio Medical University Rootstown OH 5 University of Cincinnati College of Medicine Cincinnati OH 6 Department of Pediatrics University of Cincinnati College of Medicine Cincinnati OH 7 Heart Institute (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundIn patients with ductal?dependent pulmonary blood flow, initial palliation includes catheter?based patent ductus arteriosus (PDA) stent or surgical aortopulmonary shunt (APS). This meta?analysis aimed to compare outcomes between (...) (Journal of the American Heart Association)
• 12:40
  Mortality Risk in Takotsubo Syndrome Versus Myocarditis - Alan C. Kwan, Jesse Navarrette , Patrick Botting , Melanie T. Chen , Janet Wei , C. Noel Bairey Merz , Joseph E. Ebinger , and Susan Cheng 1Department of Cardiology Barbra Streisand Women's Heart Center Smidt Heart InstituteCedars Sinai Medical Center Los Angeles CA J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. (Journal of the American Heart Association)
• 12:39
  Multifaceted Intervention to Improve P2Y12 Inhibitor Adherence After Percutaneous Coronary Intervention: A Stepped Wedge Trial - P. Michael Ho, Colin I. O’Donnell , Marina McCreight , Anthony A. Bavry , Hayden B. Bosworth , Saket Girotra , P. Michael Grossman , Christian Helfrich , Faisal Latif , David Lu , Michael Matheny , Kreton Mavromatis , Jose Ortiz , Amitabh Parashar , Devona M. Ratliff , Gary K. Grunwald , Michael Gillette , and Hani Jneid 1 Cardiology Section Rocky Mountain Regional VA Medical Center Aurora CO 2 Department of Medicine University of Colorado School of Medicine Aurora CO 3 Denver?Seattle Center of Innovation for Veteran Centered and Value Driven Care Rocky Mountain Regional VA Medical Center (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundP2Y12 inhibitor medications are critical following percutaneous coronary intervention (PCI); however, adherence remains suboptimal. Our objective was to assess the effectiveness of a multifaceted intervention to improve P2Y12 (...) (Journal of the American Heart Association)

Hypertension https://www.ahajournals.org/

• 11:02
  Influence of Obstructive Sleep Apnea Severity on Muscle Sympathetic Nerve Activity and Blood Pressure: a Systematic Review and Meta-Analysis - Lauren E. Maier Brittany A. Matenchuk Ana Vucenovic Allison Sivak Margie H. Davenport Craig D. Steinback Neurovascular Health Laboratory, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Canada. (L.E.M., A.V., C.D.S.) Program for Pregnancy and Postpartum Health, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Canada. (B.A.M., M.H.D.) H.T. Coutts Education and Physical Education Library, University of Alberta, Edmonton, Canada. (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:We conducted meta-analyses to identify relationships between obstructive sleep apnea (OSA) severity, muscle sympathetic nerve activity (MSNA), and blood pressure (BP). We quantified the effect of OSA treatment on MSNA.METHODS:Structured searches of (...) (Hypertension)
• 11:01
  Aldosterone as a Mediator of Cardiovascular Damage - Fabrizio Buffolo Martina Tetti Paolo Mulatero Silvia Monticone Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Torino, Italy. Hypertension
  Hypertension, Ahead of Print. Besides the physiological regulation of water, sodium, and potassium homeostasis, aldosterone modulates several physiological and pathological processes in the cardiovascular system. At the vascular level, aldosterone excess stimulates endothelial dysfunction and (...) (Hypertension)
• 11:01
  Age and Blood Pressure Contribute to Aortic Cell and Tissue Stiffness Through Distinct Mechanisms - Ben Ma Elaina Melton Robert Wiener Ning Zhou Wenqian Wu Lo Lai Charles Wang Kevin D. Costa Hongyu Qiu Center for Molecular and Translational Medicine, Institute of Biomedical Sciences, Georgia State University, Atlanta, GA (B.M., E.M., W.W., L.L., H.Q.). Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY (R.W., K.D.C.). Division of Physiology, Department of Basic Sciences, School of Medicine, Loma Linda University, CA (B.M., N.Z., H.Q.) Department of Basic Sciences & Center for Genomics, School of Medicine, Loma (...) Hypertension
  Hypertension, Ahead of Print. Background:Aortic stiffening is strongly associated with both aging and hypertension, but the underlying mechanisms remain unclear. We hypothesized that aging-induced aortic stiffness involves distinct pathways than stiffening from hypertension.Methods:We conducted (...) (Hypertension)
• 11:00
  Angiotensin Receptor Blockers Are Associated With a Lower Risk of Progression From Mild Cognitive Impairment to Dementia - Zhenhong Deng Jingru Jiang Jia Wang Dong Pan Yingying Zhu Honghong Li Xiaoni Zhang Xiaohuan Liu Yongteng Xu Yi Li Yamei Tang Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. (Z.D., J.J., J.W., D.P., Y.Z., H.L., X.Z.,X.L., Y.X., Y.L., Y.T.) Division of Clinical Research Design, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. (Y.Z., Y.T.) Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. (Y.T.) Guangdong (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Previous studies found that antihypertensive medications (AHMs) acting on the renin-angiotensin system had the potential to reduce the progression from mild cognitive impairment to dementia. However, it remains unclear whether this association differs (...) (Hypertension)
• 11:00
  Blood Pressure Intervention and Control in the SPRINT - William C. Cushman Robert J. Ringer Carlos J. Rodriguez Gregory W. Evans Jeffrey T. Bates Jeffrey A. Cutler Amret Hawfield Dalane W. Kitzman Ilya M. Nasrallah Suzanne Oparil John Nord Vasilios Papademetriou Karen Servilla Peter Van Buren Paul K. Whelton Jeff Whittle Jackson T. Wright Department of Preventive Medicine, University of Tennessee Health Science Center, and Medical Service, Veterans Affairs Medical Center, Memphis (W.C.C.). Department of Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM (R.J.R.). Departments of (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:The SPRINT (Systolic Blood Pressure Intervention Trial) demonstrated reductions in major cardiovascular disease events and mortality with an intensive systolic blood pressure (SBP) goal intervention. However, a detailed description of the blood pressure (...) (Hypertension)

Circulation http://ahajournals.org/

• 11:01
  Life’s Essential 8: Updating and Enhancing the American Heart Association’s Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association - Donald M. Lloyd-Jones Norrina B. Allen Cheryl A.M. Anderson Terrie Black LaPrincess C. Brewer Randi E. Foraker Michael A. Grandner Helen Lavretsky Amanda Marma Perak Garima Sharma Wayne Rosamond Circulation
  Circulation, Ahead of Print. In 2010, the American Heart Association defined a novel construct of cardiovascular health to promote a paradigm shift from a focus solely on disease treatment to one inclusive of positive health promotion and preservation across the life course in populations and (...) (Circulation)
• 11:00
  Status of Cardiovascular Health in US Adults and Children Using the American Heart Association's New "Life's Essential 8" Metrics: Prevalence Estimates from the National Health and Nutrition Examination Survey (NHANES), 2013-2018 - Donald M. Lloyd-Jones Hongyan Ning Darwin Labarthe LaPrincess Brewer Garima Sharma Wayne Rosamond Randi E. Foraker Terrie Black Michael A. Grandner Norrina B. Allen Cheryl Anderson Helen Lavretsky Amanda M. Perak Northwestern University Feinberg School of Medicine, Chicago, IL Mayo Clinic College of Medicine, Rochester, MN Johns Hopkins University School of Medicine, Baltimore, MD University of North Carolina Gillings School of Public Health, Chapel Hill, NC Washington University School of Medicine, St. Louis, MO University of Massachusetts Amherst College of Nursing, Amherst, MA (...) Circulation
  Circulation, Ahead of Print. Background:The American Heart Association (AHA) recently published an updated algorithm for quantifying cardiovascular health (CVH)—the "Life's Essential 8™" score. We quantified US levels of CVH using the new score.Methods:We included non-pregnant, (...) (Circulation)
• 11:00
  Detection of G Protein–Coupled Receptor Autoantibodies in Postural Orthostatic Tachycardia Syndrome Using Standard Methodology - Juliette Hall Kate M. Bourne Steven Vernino Viktor Hamrefors Isabella Kharraziha Jan Nilsson Robert S. Sheldon Artur Fedorowski Satish R. Raj Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Canada (J. H., K.M.B., R.S.S., S.R.R.). Department of Neurology, UT Southwestern Medical Center, Dallas, TX (S.V.). Department of Clinical Sciences, Lund University, Malmö, Sweden (V.H., I.K., J.N., A.F.). Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden (V.H.). Department of Cardiology, Karolinska University (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Postural orthostatic tachycardia syndrome (POTS) is a disorder of orthostatic intolerance that primarily affects women of childbearing age. The underlying pathophysiology of POTS is not fully understood, but it has been suggested that autoimmunity may (...) (Circulation)
• 11:00
  Effects of Early Empagliflozin Initiation on Diuresis and Kidney Function in Patients With Acute Decompensated Heart Failure (EMPAG-HF) - P. Christian Schulze Jürgen Bogoviku Julian Westphal Pawel Aftanski Franz Haertel Sissy Grund Stephan von Haehling Ulrike Schumacher Sven Möbius-Winkler Martin Busch Department of Internal Medicine I, Division of Cardiology, Angiology and Intensive Medical Care, Friedrich-Schiller-University, University Hospital Jena, Germany (P.C.S., J.B., J.W., P.A., F.H., S.G., S.M.-W.) Center for Clinical Studies, Friedrich-Schiller-University, University Hospital Jena, Germany (U.S.) Department of Internal Medicine III, Division of Nephrology, Friedrich-Schiller-University, University Hospital Jena, (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Effective diuretic regimens using loop diuretics in patients with acute decompensated heart failure are often limited by the development of worsening kidney function. Sodium-glucose cotransporter-2 inhibitors induce glucosuria and sodium excretion with (...) (Circulation)

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

• 07:28
  Effects of smoking intensity trajectory, cumulative smoking exposure, and the number of years since quitting on the subsequent risk of hypertension - Hui Fan, Xingyu Zhang J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)

Kidney Int http://www.kidney-international.org/

• 00:00
  Kidney targeting of formoterol containing polymeric nanoparticles improves recovery from ischemia reperfusion-induced acute kidney injury in mice. - Ernest L. Vallorz, Jaroslav Janda, Heidi M. Mansour, Rick G. Schnellmann Kidney Int
  The ?2 adrenergic receptor agonist, formoterol, is an inducer of mitochondrial biogenesis and restorer of mitochondrial and kidney function in acute and chronic models of kidney injury. Unfortunately, systemic administration of formoterol has the potential for adverse cardiovascular effects, (...) (Kidney International (2022))
• 00:00
  Podocyte-specific Nlrp3 inflammasome activation promotes diabetic kidney disease - Khurrum Shahzad, Sameen Fatima, Hamzah Khawaja, Ahmed Elwakiel, Ihsan Gadi, Saira Ambreen, Silke Zimmermann, Peter R. Mertens, Ronald Biemann, Berend Isermann Kidney Int
  Efficient therapies for diabetic kidney disease (DKD), now the leading cause of kidney failure, are lacking. One hallmark of DKD is sterile inflammation (inflammation in absence of microorganisms), but the underlying molecular mechanisms remain poorly understood. The NLRP3 inflammasome (innate (...) (Kidney International (2022))

28 June

Hypertension https://www.ahajournals.org/

• 11:00
  Association of Blood Pressure–Related Increase in Vascular Stiffness on Other Measures of Target Organ Damage in Youth - Jessica E. Haley Shalayna A. Woodly Stephen R. Daniels Bonita Falkner Michael Ferguson Joseph T. Flynn Coral Hanevold Stephen R. Hooper Julie R. Ingelfinger Philip R. Khoury Marc B. Lande Lisa J. Martin Kevin E. Meyers Mark Mitsnefes Richard C. Becker Bernard Rosner Joshua Samuels Andrew Tran Elaine Urbina Rady Children’s Hospital San Diego, CA (J.E.H.). Cincinnati Children’s Hospital Medical Center, OH (S.A.W., P.R.K., L.J.M., M.M., R.C.B., A.T., E.U.). Children’s Hospital Colorado, Denver (S.R.D.). Thomas Jefferson University (B.F.). Boston Children’s Hospital (M.F.). Department of (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Hypertension-related increased arterial stiffness predicts development of target organ damage (TOD) and cardiovascular disease. We hypothesized that blood pressure (BP)–related increased arterial stiffness is present in youth with elevated BP and is (...) (Hypertension)
• 11:00
  Antenatal Dexamethasone Exposure Impairs Vascular Contractile Functions via Upregulating IP3 Receptor 1 and Cav1.2 in Adult Male Offspring - Ting Xu Bingyu Ji Lingjun Li Jiahui Lei Meng Zhao Miao Sun Zhice Xu Qinqin Gao Institute for Fetology, First Hospital of Soochow University, Suzhou, China (T.X., B.J., L.L., J.L., M.Z., M.S., Z.X., Q.G.). Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Administration of antenatal glucocorticoids remains common practice for treating preterm delivery. Antenatal glucocorticoid exposure increased the risk of developing vascular diseases in later life, but the precise mechanisms remain unclear. This study (...) (Hypertension)

Circulation http://ahajournals.org/

• 11:00
  Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor–Induced Myocarditis - Han Zhu Francisco X. Galdos Daniel Lee Sarah Waliany Yuhsin Vivian Huang Julia Ryan Katherine Dang Joel W. Neal Heather A. Wakelee Sunil A. Reddy Sandy Srinivas Lih-Ling Lin Ronald M. Witteles Holden T. Maecker Mark M. Davis Patricia K. Nguyen Sean M. Wu Department of Medicine, Stanford University, CA. (H.Z., S.W., J.W.N., H.A.W., S.A.R., S.S., R.M.W., P.K.N., S.M.W.) Stanford Cardiovascular Institute, Stanford University, CA. (H.Z., F.X.G., D.L., J.R., P.K.N., S.M.W.) Stanford Cancer Institute, Stanford University, CA. (J.W.N., H.A.W., S.A.R., S.S.) Howard Hughes Medical Institute, (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Immune checkpoint inhibitors (ICIs) are monoclonal antibodies used to activate the immune system against tumor cells. Despite therapeutic benefits, ICIs have the potential to cause immune-related adverse events such as myocarditis, a rare but serious side (...) (Circulation)
• 11:00
  Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1?, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy - Paul M. Ridker Nader Rifai Jean MacFadyen Robert J. Glynn Lixia Jiao Ph. Gabriel Steg Michael Miller Eliot A. Brinton Terry A. Jacobson Jean-Claude Tardif Christie M. Ballantyne R. Preston Mason Deepak L. Bhatt Brigham and Women’s Hospital, Boston, MA (P.M.R., J.M., R.J.G., R.P.M., D.L.B.). Children’s Hospital Medical Center, Boston, MA (N.R.). Amarin Pharma, Bridgewater, NJ (L.J.). Université de Paris, FACT and INSERM-U1148, F75018 and Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, France (P.G.S.). University of Maryland School of Medicine, Baltimore (M.M.). Utah Lipid Center, Salt (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:REDUCE-IT (Reduction of Cardiovascular Events With Icosapent Ethyl—Intervention Trial) reported a 25% relative risk reduction in major adverse cardiovascular events with use of icosapent ethyl compared with pharmaceutical grade mineral oil. The mechanisms (...) (Circulation)
• 11:00
  Empagliflozin for Heart Failure With Preserved Left Ventricular Ejection Fraction With and Without Diabetes - Gerasimos Filippatos Javed Butler Dimitrios Farmakis Faiez Zannad Anne Pernille Ofstad João Pedro Ferreira Jennifer B. Green Julio Rosenstock Sven Schnaidt Martina Brueckmann Stuart J. Pocock Milton Packer Stefan D. Anker National and Kapodistrian University of Athens School of Medicine, Athens University Hospital Attikon, Greece (G.F.). Baylor Scott and White Research Institute, Dallas, TX (J.B.). Department of Medicine, University of Mississippi School of Medicine, Jackson (J.B.). University of Cyprus Medical School, Nicosia (D.F.). Centre d’Investigations Cliniques Plurithématique 14-33, (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Empagliflozin improves outcomes in patients with heart failure with a preserved ejection fraction, but whether the effects are consistent in patients with and without diabetes remains to be elucidated.METHODS:Patients with class II through IV heart (...) (Circulation)

Diabetologia http://link.springer.com/

• 00:00
  Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease Diabetologia
  Abstract Aims/hypothesis Diabetic kidney disease (DKD) is the leading cause of kidney failure and has a substantial genetic component. Our aim was to identify novel genetic factors and genes contributing to DKD by performing meta-analysis of previous genome-wide association studies (GWAS) on (...)
• 00:00
  Clinical variable-based cluster analysis identifies novel subgroups with a distinct genetic signature, lipidomic pattern and cardio-renal risks in Asian patients with recent-onset type 2 diabetes Diabetologia
  Abstract Aims/hypothesis We sought to subtype South East Asian patients with type 2 diabetes by de novo cluster analysis on clinical variables, and to determine whether the novel subgroups carry distinct genetic and lipidomic features as well as differential cardio-renal risks. Methods (...)

27 June

Stroke https://www.ahajournals.org/

• 08:00
  Focused Update on Vascular Risk and Secondary Prevention in Survivors of Intracerebral Hemorrhage - Kevin N. Sheth Magdy Selim Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale School of Medicine, New Haven, CT (K.N.S.). Division of Stroke and Cerebrovascular Disease, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (M.S.). Stroke
  Stroke, Volume 53, Issue 7, Page 2128-2130, July 1, 2022. (Stroke)
• 08:00
  Local Versus General Anesthesia for Carotid Endarterectomy: Cochrane Review - Amaraporn Rerkasem Sothida Nantakool Saritphat Orrapin Peter M. Rothwell Dominic P.J. Howard Kittipan Rerkasem Environmental - Occupational Health Sciences and Non Communicable Diseases Research Group (EOHS and NCD Research Group), Research Institute for Health Sciences (A.R., S.N., K.R.), Chiang Mai University, Thailand. Clinical Surgical Research Center, Faculty of Medicine (K.R.), Chiang Mai University, Thailand. Department of Surgery, Faculty of Medicine (K.R.), Chiang Mai University, Thailand. Division of Vascular Surgery, Department of Surgery, Faculty of Medicine, Thammasat (...) Stroke
  Stroke, Volume 53, Issue 7, Page e267-e268, July 1, 2022. (Stroke)
• 08:00
  July Literature Synopsis - Terence J. Quinn Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom. Stroke
  Stroke, Volume 53, Issue 7, Page e271-e272, July 1, 2022. (Stroke)
• 08:00
  Carotid Sources of Stroke - J.P. Mohr Daniel Sciarra Professor of Neurology, Doris & Stanley Tananbaum Stroke Center, Neurological Institute, Columbia University Irving Medical Center, NY. Stroke
  Stroke, Volume 53, Issue 7, Page e259-e263, July 1, 2022. The ancient Greeks used the term karotides for the great arteries in the neck, compression of which could plunge the victim into karoun: deep sleep or stupor. The artery name aside, studies of the patterns of brain infarction and their (...) (Stroke)
• 08:00
  Protecting the Brain, From the Heart: Safely Mitigating the Consequences of Thrombosis in Intracerebral Hemorrhage Survivors With Atrial Fibrillation - Laurent Puy Rachel Forman Charlotte Cordonnier Kevin N. Sheth Stroke
  Stroke, Volume 53, Issue 7, Page 2152-2160, July 1, 2022. Optimal antithrombotic management after intracerebral hemorrhage remains one of the central unresolved issues for patients who survive, especially for those patients with atrial fibrillation. Given the observational nature of the studies (...) (Stroke)
• 08:00
  Information Provision for Stroke Survivors and Their Carers: Cochrane Review - Thomas F. Crocker Lesley Brown Natalie Lam Faye Wray Peter Knapp Anne Forster Academic Unit for Ageing and Stroke Research (University of Leeds), Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, United Kingdom (T.F.C., L.B., N.L., F.W., A.F.). Department of Health Sciences, University of York, the Hull York Medical School, United Kingdom (P.K.). Stroke
  Stroke, Volume 53, Issue 7, Page e269-e270, July 1, 2022. (Stroke)
• 08:00
  Correction to: Clinical Results of the Advanced Neurovascular Access Catheter System Combined With a Stent Retriever in Acute Ischemic Stroke (SOLONDA) Stroke
  Stroke, Volume 53, Issue 7, Page e362-e362, July 1, 2022. (Stroke)
• 08:00
  Organizational Update: World Stroke Conference 2021 - Ana Catarina Fonseca Sean I. Savitz Department of Neurology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal (A.C.F.). JMFerro Lab, Instituto de Medicina Molecular, Centro de Estudos Egas Moniz, Faculdade de Medicina, Universidade de Lisboa, Portugal (A.C.F.). Institute for Stroke and Cerebrovascular Disease, University of Texas Health Science Center, Houston (S.I.S.). Stroke
  Stroke, Volume 53, Issue 7, Page e264-e266, July 1, 2022. (Stroke)
• 08:00
  July 2022 Stroke Highlights - José Rafael Romero Stroke
  Stroke, Volume 53, Issue 7, Page 2127-2127, July 1, 2022. (Stroke)

Circulation http://ahajournals.org/

• 11:00
  Novel Smooth Muscle Ca2+-Signaling Nanodomains in Blood Pressure Regulation - Yen-Lin Chen Zdravka Daneva Maniselvan Kuppusamy Matteo Ottolini Thomas M. Baker Eliska Klimentova Soham A. Shah Jennifer D. Sokolowski Min S. Park Swapnil K. Sonkusare Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville. (Y.-L.C., Z.D., M.K., M.O., T.M.B., E.K., S.K.S.) Departments of Neurosurgery, University of Virginia, Charlottesville. (S.A.S.) Biomedical Engineering, University of Virginia, Charlottesville. (J.D.S., M.S.P.) Molecular Physiology and Biological Physics, University of Virginia, Charlottesville. (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Ca2+signals in smooth muscle cells (SMCs) contribute to vascular resistance and control blood pressure. Increased vascular resistance in hypertension has been attributed to impaired SMC Ca2+signaling mechanisms. In this regard, transient receptor (...) (Circulation)

Kidney Int http://www.kidney-international.org/

• 00:00
  A nationwide Dutch cohort study shows relatively good pregnancy outcomes after kidney transplantation and finds risk factors for adverse outcomes - Margriet E. Gosselink, Marleen C. van Buren, Judith Kooiman, Henk Groen, Wessel Ganzevoort, Henk W. van Hamersvelt, Olivier W.H. van der Heijden, Jacqueline van de Wetering, Titia Lely Kidney Int
  Although numbers of pregnancy after kidney transplantation (KT) are rising, high risks of adverse pregnancy outcomes (APO) remain. Though important for pre-conception counselling and pregnancy monitoring, analyses of pregnancy outcomes after KT per pre-pregnancy estimated glomerular filtration (...) (Kidney International (2022))

J Human Hypertens http://www.nature.com/jhh/

• 00:00
  Industry perspectives on the global use of validated blood pressure measuring devices - Jim Li, Gerhard Frick, Karel Herberigs, Paul Matsumura, Josh Sarkis, Willem J. Verberk, Caryl Wojcik J Human Hypertens
  Journal of Human Hypertension, Published online: 27 June 2022; doi:10.1038/s41371-022-00717-6Industry perspectives on the global use of validated blood pressure measuring devices (Journal of Human Hypertension, Published online: 2022-06-27; | doi:10.1038/s41371-022-00717-6)

Kidney Int http://www.kidney-international.org/

• 00:00
  The Dutch Childhood Cancer Survivor Study (DCCSS)-LATER 2 kidney analysis examined long-term glomerular dysfunction in childhood cancer survivors. - Esmee C.M. Kooijmans, Helena J.H. van der Pal, Saskia M.F. Pluijm, Margriet van der Heiden-van der Loo, Leontien C.M. Kremer, Dorine Bresters, Eline van Dulmen-den Broeder, Marry M. van den Heuvel-Eibrink, Jacqueline J. Loonen, Marloes Louwerens, Sebastian J.C. Neggers, Cécile Ronckers, Wim J.E. Tissing, Andrica C.H. de Vries, Gertjan J.L. Kaspers, Margreet A. Veening, Arend Bökenkamp, Dutch LATER study group Kidney Int
  This investigation aimed to evaluate glomerular dysfunction among childhood cancer survivors in comparison with matched controls from the general population. In the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER 2 kidney analysis, a nationwide cross-sectional cohort study, 1024 survivors (...) (Kidney International (2022))

25 June

J Human Hypertens http://www.nature.com/jhh/

• 00:00
  The association between salt intake and blood pressure is mediated by body mass index but modified by hypertension: The ELSA-Brasil study - Suellen Ferreira Chagas, Divanei Zaniqueli, Marcelo Perim Baldo, Paulo Andrade Lotufo, Bruce B. Duncan, Rosane Harter Griep, Isabela Martins Benseñor, Rafael de Oliveira Alvim, José Geraldo Mill J Human Hypertens
  Journal of Human Hypertension, Published online: 25 June 2022; doi:10.1038/s41371-022-00714-9The association between salt intake and blood pressure is mediated by body mass index but modified by hypertension: The ELSA-Brasil (...) (Journal of Human Hypertension, Published online: 2022-06-25; | doi:10.1038/s41371-022-00714-9)

24 June

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

• 14:55
  Associations of blood pressure components with risks of cardiovascular events and all?cause death in a Chinese population: A Prospective Study - Zhongying Zhang, Xiang Gu, Zhe Tang, Shaochen Guan, Hongjun Liu, Xiaoguang Wu, Yan Zhao, Xianghua Fang J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)
• 14:54
  Association between serum uric acid and arterial stiffness in a large?aged 40–70 years old population - Alexandre Vallée J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)
• 09:45
  Association between serum manganese levels and diabetes in chinese adults with hypertension - Hong Chen, Zhixin Cui, Wenhai Lu, Ping Wang, Jia Wang, Ziyi Zhou, Nan Zhang, Zhuo Wang, Tengfei Lin, Yun Song, Lishun Liu, Xiao Huang, Ping Chen, Genfu Tang, Yong Duan, Binyan Wang, Hao Zhang, Xiping Xu, Yan Yang, Xianhui Qin, Fenglin Song J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)
• 05:13
  Potential triggering factors associated with aneurysmal subarachnoid hemorrhage: A large single?center retrospective study - Runting Li, Xiaolin Chen, Yuanli Zhao J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)
• 05:09
  High waist circumference is a risk factor for hypertension in normal?weight or overweight individuals with normal metabolic profiles - Chen Cheng, Jin?Yu Sun, Ying Zhou, Qi?Yang Xie, Li?Yuan Wang, Xiang?Qing Kong, Wei Sun J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)

Stroke https://www.ahajournals.org/

• 11:00
  Comparison of Computed Tomography Perfusion and Multiphase Computed Tomography Angiogram in Predicting Clinical Outcomes in Endovascular Thrombectomy - Zefeng Tan Mark Parsons Andrew Bivard Gagan Sharma Peter Mitchell Richard Dowling Steven Bush Leonid Churilov Anding Xu Bernard Yan Department of Neurology, the First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China (Z.T., A.X.). Melbourne Brain Centre at Royal Melbourne Hospital, University of Melbourne, Australia (Z.T., M.P., A.B., G.S., L.C., B.Y.). Department of Neurology, the First People’s Hospital of Foshan, China (Z.T.). Neurointervention Service, Department of Radiology, Royal Melbourne Hospital, Australia (P.M., R.D., S.B., (...) Stroke
  Stroke, Ahead of Print. Background:In patients with acute stroke who undergo endovascular thrombectomy, the relative prognostic power of computed tomography perfusion (CTP) parameters compared with multiphase CT angiogram (mCTA) is unknown. We aimed to compare the predictive accuracy of mCTA (...) (Stroke)
• 11:00
  Problem in the Recent American Heart Association Guideline on Secondary Stroke Prevention: B Vitamins to Lower Homocysteine Do Prevent Stroke - J. David Spence Graeme J. Hankey Divisions of Neurology and Clinical Pharmacology, Western University, London, ON, Canada (J.D.S.). Medical School, Faculty of Health and Medical Sciences, The University of Western Australia, Perth, Australia (G.J.H.). Stroke
  Stroke, Ahead of Print. In this article, we discuss a problem in the most recent American Heart Association guideline on secondary stroke prevention that apparently arose from the rules of evidence imposed on the guideline panel. We are told by the cochair of the panel that American Heart (...) (Stroke)

Circulation http://ahajournals.org/

• 11:00
  Socioeconomic Deprivation: An Important, Largely Unrecognized Risk Factor in Primary Prevention of Cardiovascular Disease - Dorien M. Kimenai Leah Pirondini John Gregson David Prieto Stuart J. Pocock Pablo Perel Tilly Hamilton Paul Welsh Archie Campbell David J. Porteous Caroline Hayward Naveed Sattar Nicholas L. Mills Anoop S. V. Shah BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom. (D. M.K., T.H., N.L.M.) Centre for Genomic and Experimental Medicine, University of Edinburgh, United Kingdom. (A.C., D.J.P.) MRC Human Genetics Unit, University of Edinburgh, United Kingdom. (C.H.) Institute of Genetics and Cancer, Usher Institute, University of Edinburgh, United Kingdom. (N.L.M.) (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Socioeconomic deprivation is associated with higher cardiovascular morbidity and mortality. Whether deprivation status should be incorporated in more cardiovascular risk estimation scores remains unclear. This study evaluates how socioeconomic deprivation (...) (Circulation)

Diabetes https://diabetes.diabetesjournals.org

• 02:00
  Issues and Events Diabetes

Diabetologia http://link.springer.com/

• 00:00
  Continuous glucose monitoring and hypoglycaemia events: unmet needs. Reply to Papaioannou TG, Snoudou D and Tsiofis C [letter] Diabetologia
• 00:00
  A roadmap to achieve pharmacological precision medicine in diabetes Diabetologia
  Abstract Current pharmacological treatment of diabetes is largely algorithmic. Other than for cardiovascular disease or renal disease, where sodium–glucose cotransporter 2 inhibitors and/or glucagon-like peptide-1 receptor agonists are indicated, the choice of treatment is based upon overall (...)

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Salt substitution: opportunities and challenges for nephrology - Ewout J. Hoorn, Matti Marklund, Jason H. Y. Wu Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 24 June 2022; doi:10.1038/s41581-022-00599-4Salt substitution — the partial replacement of sodium with potassium in table salt — is emerging as a powerful public health strategy to reduce hypertension and related diseases. Here, we explore whether salt (...) (Nature Reviews Nephrology, Published online: 2022-06-24; | doi:10.1038/s41581-022-00599-4)

Kidney Int http://www.kidney-international.org/

• 00:00
  Vonoprazan-associated nephrotoxicity: extensive real-world evidence from spontaneous adverse drug reaction reports - Masayuki Ishida, Masami Tsuchiya, Junko Naito, Hitoshi Kawazoe, Daichi Watanabe, Yujiro Nonaka, Mika Sano, Hiroyasu Sakai, Akio Suzuki, Keisuke Kumada, Hiroyuki Okura, Masahito Shimizu, Hirotoshi Iihara Kidney Int
  Vonoprazan, a potassium-competitive acid blocker (P-CAB) possessing a new mechanism of action, was first approved in Japan in 2015 for the treatment of acid-related diseases. Vonoprazan inhibits acid secretion in the cells of the gastric wall. The inhibitory effect of vonoprazan on H+, (...) (Kidney International (2022))
• 00:00
  Expression of active B-Raf proto-oncogene in kidney collecting ducts induces cyst formation in normal mice and accelerates cyst growth in mice with polycystic kidney disease. - Stephen C. Parnell, Archana Raman, Yan Zhang, Emily A. Daniel, Yuqiao Dai, Aditi Khanna, Gail A. Reif, Jay L. Vivian, Timothy A. Fields, Darren P. Wallace Kidney Int
  Polycystic kidney disease (PKD) is characterized by the formation and progressive enlargement of fluid-filled cysts due to abnormal cell proliferation. Cyclic AMP agonists, including arginine vasopressin, stimulate ERK-dependent proliferation of cystic cells, but not normal kidney cells. (...) (Kidney International (2022))
• 00:00
  A tool for decision-making in kidney transplant candidates with poor prognosis to receive deceased donor transplantation in the United States. - Jesse D. Schold, Anne M. Huml, Emilio D. Poggio, Peter P. Reese, Sumit Mohan Kidney Int
  The primary outcomes for kidney transplant candidates are receipt of deceased or living donor transplant, death or removal from the waiting list. Here, we conducted a retrospective analysis of national Scientific Registry of Transplant Recipients data to evaluate outcomes for 208,717 adult (...) (Kidney International (2022))

23 June

Stroke https://www.ahajournals.org/

• 11:00
  Stroke Outcomes in Women: A Population-Based Cohort Study - Min Xu Adriana Amarilla Vallejo Clara Cantalapiedra Calvete Anthony Rudd Charles Wolfe Matthew D.L. O’Connell Abdel Douiri School of Population Health and Environmental Sciences, King’s College London, United Kingdom. (M.X., C.C.C., A.R., C.W., M.D.L.O., A.D.) School of Immunology and Microbial Sciences, King’s College London, United Kingdom. (A.A.V.) Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom (A.R.). National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, United Kingdom (C.W., (...) Stroke
  Stroke, Ahead of Print. BACKGROUND:Limited data are available on sex-related disparities in long-term outcomes after stroke. We estimated sex differences in various stroke long-term outcomes among survivors after stroke in a prospective 25-year follow-up study.METHODS:Individuals recruited to (...) (Stroke)
• 11:00
  Intravenous tPA (Tissue-Type Plasminogen Activator) Correlates With Favorable Venous Outflow Profiles in Acute Ischemic Stroke - Tobias D. Faizy Michael Mlynash Michael P. Marks Soren Christensen Reza Kabiri Gabriella M. Kuraitis Gabriel Broocks Laurens Winkelmeier Vincent Geest Jawed Nawabi Maarten G. Lansberg Gregory W. Albers Jens Fiehler Max Wintermark Jeremy J. Heit Department of Radiology, Stanford University School of Medicine, CA (M.P.M., G.M.K., J.J.H.). Department of Neurology and Neurological Sciences, Stanford University School of Medicine, CA (M.M., S.C., M.G.L., G.W.A.). Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Germany (T.D.F., R.K., G.B., L.W., V.G., J.F.). (...) Stroke
  Stroke, Ahead of Print. BACKGROUND:Intravenous tPA (tissue-type plasminogen activator) is often administered before endovascular thrombectomy (EVT). Recent studies have questioned whether tPA is necessary given the high rates of arterial recanalization achieved by EVT, but whether tPA impacts (...) (Stroke)
• 11:00
  Oral Contraceptives, Hormone Replacement Therapy, and Stroke Risk - Therese Johansson Philip Fowler Weronica E. Ek Alkistis Skalkidou Torgny Karlsson Åsa Johansson Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden. (T.J., W.E.E., T.K., A.J.) Centre for Women’s Mental Health during the Reproductive Lifespan – Womher, Uppsala University, Sweden. (T.J.) Department of Statistics, Uppsala University, Sweden. (P.F.) Department of Women’s and Children’s Health, Uppsala University, Sweden. (...) Stroke
  Stroke, Ahead of Print. BACKGROUND:Millions of women worldwide use exogenous hormones as oral contraceptives or hormone replacement therapy. Still, time-dependent and long-term consequences of exogenous hormones on stroke risk remains unclear.METHODS:We examined the association between (...) (Stroke)

Circulation http://ahajournals.org/

• 11:00
  Effects of Coronary Artery Disease–Associated Variants on Vascular Smooth Muscle Cells - Charles U. Solomon David G. McVey Catherine Andreadi Peng Gong Lenka Turner Paulina J. Stanczyk Sonja Khemiri Julie C. Chamberlain Wei Yang Tom R. Webb Christopher P. Nelson Nilesh J. Samani Shu Ye Department of Cardiovascular Sciences, University of Leicester, and National Institute for Health Research Leicester Biomedical Research Centre, UK (C.U.S., D.G.M., C.A., P.G., L.T., P.J.S., S.K., J.C.C., T.R.W., C.P.N., J.N.S., S.Y.). Shantou University Medical College, China (W.Y., S.Y.). Cardiovascular Disease Translational Research Programme, Department of Medicine, National University of (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Genome-wide association studies have identified many genetic loci that are robustly associated with coronary artery disease (CAD). However, the underlying biological mechanisms are still unknown for most of these loci, hindering the progress to medical (...) (Circulation)

J Human Hypertens http://www.nature.com/jhh/

• 00:00
  Effect of hypertensive disorders of pregnancy on pubertal development in daughters and sons: a systematic review and meta-analysis - Ziqi Yang, Xuan Zhou, Ziqiang Gong, Senmao Zhang, Xiaoling Liu, Yan Chen, Changxiang Ye, Lizhang Chen, Tingting Wang J Human Hypertens
  Journal of Human Hypertension, Published online: 23 June 2022; doi:10.1038/s41371-022-00715-8Effect of hypertensive disorders of pregnancy on pubertal development in daughters and sons: a systematic review and meta-analysis (Journal of Human Hypertension, Published online: 2022-06-23; | doi:10.1038/s41371-022-00715-8)

Diabetologia http://link.springer.com/

• 00:00
  Continuous glucose monitoring and hypoglycaemia events: unmet needs Diabetologia

22 June

Stroke https://www.ahajournals.org/

• 11:00
  Carotid Stenting Versus Endarterectomy for Asymptomatic Carotid Artery Stenosis: A Systematic Review and Meta-Analysis - Jie Wang Xuesong Bai Tao Wang Adam A. Dmytriw Aman B. Patel Liqun Jiao China International Neuroscience Institute (China-INI), Peoples Republic of China (J.W., X.B., T.W., L.J.). Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, Peoples Republic of China (J.W., X.B., T.W., L.J.). Neuroendovascular Program, Massachusetts General Hospital, Harvard Medical School, Boston (A.A.D.). Department of Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, Peoples Republic of China (...) Stroke
  Stroke, Ahead of Print. Background:To compare safety and efficacy between carotid artery stenting (CAS) and carotid endarterectomy (CEA) in treating asymptomatic carotid artery stenosis based on results from randomized controlled trials.Methods:Randomized controlled trials comparing CAS and CEA (...) (Stroke)
• 11:00
  Cannabis Use Is Not Associated With Aneurysmal Subarachnoid Hemorrhage Complications or Outcomes - Feras Akbik Heather-Destiny Konan Kayla P. Williams Leelt M. Ermias Yuyang Shi Obai Takieddin Jonathan A. Grossberg Brian M. Howard Frank Tong C. Michael Cawley Yajun Mei Owen B. Samuels Ofer Sadan Department of Neurology and Neurosurgery, Division of Neurocritical Care, Emory University School of Medicine, Atlanta, GA. (F.A., O.T., O.S.) Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA. (J.A.G., B.M.H., F.T., C.M.C., O.B.S.) Emory College, Atlanta, GA (H.-D.K., K.P.W., L.M.E.). H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute (...) Stroke
  Stroke, Ahead of Print. (Stroke)

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

• 12:33
  Integrated Multilayer Omics Reveals the Genomic, Proteomic, and Metabolic Influences of Histidyl Dipeptides on the Heart - Keqiang Yan, Zhanlong Mei , Jingjing Zhao , Md Aminul Islam Prodhan , Detlef Obal , Kartik Katragadda , Benjamin Doelling , David Hoetker , Dheeraj Kumar Posa , Liqing He , Xinmin Yin , Jasmit Shah , Jianmin Pan , Shesh Rai , Pawel Konrad Lorkiewicz , Xiang Zhang , Siqi Liu , Aruni Bhatnagar , and Shahid P. Baba 1 Beijing Institute of Genomics Chinese Academy of Sciences, Beishan Industrial Zone Shenzhen China 2 Diabetes and Obesity Center University of Louisville KY 3 Christina Lee Brown Envirome Institute University of Louisville KY USA 4 Department of Chemistry University of Louisville (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundHistidyl dipeptides such as carnosine are present in a micromolar to millimolar range in mammalian hearts. These dipeptides facilitate glycolysis by proton buffering. They form conjugates with reactive aldehydes, such as (...) (Journal of the American Heart Association)
• 12:33
  Exploring Health Care Providers' Experiences of Providing Collaborative Palliative Care for Patients With Advanced Heart Failure At Home: A Qualitative Study - Cassandra Graham, Rebecca Schonnop , Tieghan Killackey , Dio Kavalieratos , Shirley H. Bush , Leah Steinberg , Susanna Mak , Kieran Quinn , and Sarina R. Isenberg 1 Division of Palliative Medicine, Department of Medicine University of Toronto Toronto Canada 2 Division of Palliative Care University Health Network Toronto Canada 3 Department of Emergency Medicine University of Alberta Edmonton Canada 4 Department of Emergency Medicine Royal Alexandra Hospital Edmonton Canada 5 Child Health Evaluative Sciences The Hospital for Sick Children Toronto Canada 6 Division of Palliative Medicine (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundThe HeartFull Collaborative is a regionally organized model of care which involves specialist palliative care and cardiology health care providers (HCPs) in a collaborative, home?based palliative care approach for patients with (...) (Journal of the American Heart Association)
• 12:33
  Temporal Changes in Beat?to?Beat Variability of Repolarization Predict Imminent Nonsustained Ventricular Tachycardia in Patients With Ischemic and Nonischemic Dilated Cardiomyopathy - Matthew Amoni, Sebastian Ingelaere , Jonathan Moeyersons , Bert Vandenberk , Piet Claus , Robin Lemmens , Sabine Van Huffel , Karin Sipido , Carolina Varon , and Rik Willems 1 Cardiology University Hospitals Leuven Leuven Belgium 2 Experimental Cardiology, Department of Cardiovascular Sciences University of Leuven Belgium 3 STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, Department of Electrical Engineering University of Leuven Belgium 4 Imaging and Cardiovascular Dynamics, Department of Cardiovascular Sciences KU Leuven Leuven Belgium 5 Neurology University (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundAn increase in beat?to?beat variability of repolarization (BVR) predicts arrhythmia onset in experimental models, but its clinical translation is not well established. We investigated the temporal changes in BVR before (...) (Journal of the American Heart Association)
• 12:33
  Quantification of Cardiac Adipose Tissue in Failing and Nonfailing Human Myocardium - Kyra K. Peczkowski, Mohammed A. Mashali , Nancy S. Saad , Austin Hare , Courtney M. Campbell , Bryan A. Whitson , Nahush A. Mokadam , and Paul M. L. Janssen 1 Department of Physiology and Cell Biology College of Medicine The Ohio State University Columbus OH 2 Dorothy M. Davis Heart and Lung Research Institute The Ohio State University Columbus OH 3 Department of Internal Medicine College of Medicine The Ohio State University Columbus OH 4 Division of Cardiac Surgery College of Medicine The Ohio State University Columbus (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundBecause body mass index (BMI) is generally used clinically to define obesity and to estimate body adiposity, BMI likely is positively correlated with epicardial adipose tissue (EAT) level. Based on echocardiography, previous (...) (Journal of the American Heart Association)
• 12:32
  Safety and Efficacy of SSRIs in Improving Poststroke Recovery: A Systematic Review and Meta?Analysis - Heba M. Kalbouneh, Ahmad A. Toubasi , Farah H. Albustanji , Yazan Y. Obaid , and Layla M. Al?Harasis 1Department of Anatomy Faculty of Medicine University of Jordan Amman Jordan 2Faculty of Medicine University of Jordan Amman Jordan 3Faculty of Medicine Jordan University of Science and Technology Irbid Jordan J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundSeveral studies investigated the role of selective serotonin reuptake inhibitors (SSRIs) in improving poststroke recovery; thus, we have decided to conduct this systematic review and meta?analysis to investigate the efficacy (...) (Journal of the American Heart Association)
• 12:32
  Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice - Jared M. McLendon, Xiaoming Zhang , Daniel S. Matasic , Mohit Kumar , Olha M. Koval , Isabella M. Grumbach , Sakthivel Sadayappan , Barry London , and Ryan L. Boudreau 1Department of Internal Medicine University of Iowa Carver College of Medicine Iowa City IA 2Abboud Cardiovascular Research Center University of Iowa Carver College of Medicine Iowa City IA 3Department of Molecular Physiology and Biophysics University of Iowa Carver College of Medicine Iowa City IA 4Department of Pharmacology and Systems Physiology University of Cincinnati OH 5Division of Cardiovascular Health and Disease (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundSorbin and SH3 domain containing 2 (Sorbs2) protein is a cytoskeletal adaptor with an emerging role in cardiac biology and disease; yet, its potential relevance to adult?onset cardiomyopathies remains underexplored. Sorbs2 (...) (Journal of the American Heart Association)
• 12:32
  Aspirin Therapy on Prophylactic Anticoagulation for Patients Hospitalized With COVID?19: A Propensity Score?Matched Cohort Analysis of the HOPE?COVID?19 Registry - Francesco Santoro, Ivan J. Núñez?Gil , Enrica Vitale , María C. Viana?Llamas , Rodolfo Romero , Charbel Maroun Eid , Gisela Feltes Guzman , Victor Manuel Becerra?Muñoz , Inmaculada Fernández Rozas , Aitor Uribarri , Emilio Alfonso?Rodriguez , Marcos García Aguado , Jia Huang , Alex Fernando Castro Mejía , Juan Fortunato Garcia Prieto , Javier Elola , Fabrizio Ugo , Enrico Cerrato , Jaime Signes?Costa , Sergio Raposeiras Roubin , Jorge Luis Jativa Mendez , Carolina Espejo Paeres , Alvaro López Masjuan , Francisco Marin , Federico Guerra , Ibrahim El?Battrawy , Bernardo Cortese , Harish Ramakrishna (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundCOVID?19 is an infectious illness, featured by an increased risk of thromboembolism. However, no standard antithrombotic therapy is currently recommended for patients hospitalized with COVID?19. The aim of this study was to (...) (Journal of the American Heart Association)
• 12:32
  Rheumatic Heart Disease Is a Neglected Disease Relative to Its Burden Worldwide: Findings From Global Burden of Disease 2019 - Seyyed?Hadi Ghamari, Mohsen Abbasi?Kangevari , Sahar Saeedi Moghaddam , Arya Aminorroaya , Negar Rezaei , Parnian Shobeiri , Zahra Esfahani , Mohammad?Reza Malekpour , Nazila Rezaei , Ali Ghanbari , Mohammad Keykhaei , Mohammadreza Naderian , Bagher Larijani , Mohamad Taghi Majnoon , Farshad Farzadfar , and Ali H. Mokdad 1Non?Communicable Diseases Research Center Endocrinology and Metabolism Population Sciences Institute Tehran University of Medical Sciences Tehran Iran 2Tehran Heart CenterTehran University of Medical Sciences Tehran Iran 3Endocrinology and Metabolism Research Center (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundRheumatic heart disease (RHD) takes a heavy toll in low? and middle?income countries. We aimed to present worldwide estimates for the burden of the RHD during 1990 to 2019 using the GBD (Global Burden of Disease) study.Methods (...) (Journal of the American Heart Association)
• 12:31
  Postnatal Deletion of Bmal1 in Cardiomyocyte Promotes Pressure Overload Induced Cardiac Remodeling in Mice - Qing Liang, Hu Xu , Min Liu , Lei Qian , Jin Yan , Guangrui Yang , and Lihong Chen 1Advanced Institute for Medical Sciences Dalian Medical University Dalian China 2School of Bioengineering Dalian University of Technology Dalian China J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundMice with cardiomyocyte?specific deletion of Bmal1, a core clock gene, had spontaneous abnormal cardiac metabolism, dilated cardiomyopathy, and shortened lifespan. However, the role of cardiomyocyte Bmal1 in pressure overload (...) (Journal of the American Heart Association)
• 12:31
  Health State Utility Values in People With Stroke: A Systematic Review and Meta?Analysis - Raed A. Joundi, Joel Adekanye , Alexander A. Leung , Paul Ronksley , Eric E. Smith , Alexander D. Rebchuk , Thalia S. Field , Michael D. Hill , Stephen B. Wilton , and Lauren C. Bresee 1Department of Clinical Neurosciences University of Calgary Alberta Canada 2Division of Neurology Hamilton Health SciencesMcMaster University & Population Health Research Institute Hamilton Ontario Canada 3University of Calgary Calgary Alberta Canada 4University of British Columbia Vancouver British Columbia Canada 5Department of Community Health Sciences University of Calgary Alberta (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundHealth state utility values are commonly used to provide summary measures of health?related quality of life in studies of stroke. Contemporaneous summaries are needed as a benchmark to contextualize future observational studies (...) (Journal of the American Heart Association)
• 12:31
  Racial and Ethnic Differences in Cardiac Rehabilitation Participation: Effect Modification by Household Income - Joshua Garfein, Emily N. Guhl , Gretchen Swabe , Akira Sekikawa , Emma Barinas?Mitchell , Daniel E. Forman , and Jared W. Magnani 1 Department of Medicine University of Pittsburgh School of Medicine Pittsburgh PA 2 Heart and Vascular Institute University of Pittsburgh Medical Center Pittsburgh PA 3 Department of Epidemiology, Graduate School of Public Health University of Pittsburgh PA J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundCardiac rehabilitation (CR) is associated with improved cardiovascular outcomes. Racial and ethnic differences in CR have been identified, but whether income may attenuate these disparities remains unknown. We evaluated (1) (...) (Journal of the American Heart Association)
• 12:30
  To Be or Not to Be: Surviving Immune?Mediated Fetal Heart Disease - Edgar Jaeggi, Lisa Hornberger , Bettina Cuneo , Anita J. Moon?Grady , Marie?Josée Raboisson , Jane Lougheed , Karim Diab , Wadi Mawad , and Earl Silverman 1Labatt Family Heart Centre The Hospital for Sick Children Toronto Ontario Canada 2Labatt Family Heart Centre Stollery Children’s Hospital University of Alberta Edmonton Alberta Canada 3Labatt Family Heart Centre Children’s Hospital Colorado Denver CO 4Labatt Family Heart Centre UCSF Benioff Children's Hospital San Francisco CA 5Labatt Family Heart Centre Centre Hospitalier Universitaire Sainte Justine Montréal Quebec Canada 6Labatt Family (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. (Journal of the American Heart Association)
• 12:30
  To Be or Not to Be Treated: That Is the Question in Managing a Fetus With Cardiac Injury Exposed to Anti?SSA/Ro - Jill Buyon, Amit Saxena , Deborah Friedman , and Peter Izmirly 1Division of Rheumatology Department of Medicine New York University Grossman School of Medicine New York NY 2Department of Pediatrics New York Medical College Valhalla NY J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. (Journal of the American Heart Association)
• 12:30
  Relationship of Sodium Intake With Granulocytes, Renal and Cardiovascular Outcomes in the Prospective EPIC?Norfolk Cohort - Eliane F. E. Wenstedt, Hessel Peters Sengers , S. Matthijs Boekholdt , Kay?Tee Khaw , Nicholas J. Wareham , Bert?Jan H. van den Born , and Liffert Vogt 1Department of Internal Medicine Section of Nephrology Amsterdam UMC University of AmsterdamAmsterdam Cardiovascular Sciences Amsterdam The Netherlands 2Amsterdam UMC University of AmsterdamCenter for Experimental and Molecular Medicine Amsterdam The Netherlands 3Amsterdam UMC The Amsterdam Institute for Infection and Immunity Amsterdam The Netherlands 4Department of Cardiology Amsterdam UMC University of Amsterdam The Netherlands (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundExperimental studies show that high?sodium intake affects the innate immune system, among others with increased circulating granulocytes. Whether this relationship exists on a population level and whether this relates to (...) (Journal of the American Heart Association)
• 12:29
  Arrhythmia Monitoring and Outcomes in Patients With Cardiac Sarcoidosis: Insights From the Cardiac Sarcoidosis Consortium - Edoardo Bressi, Thomas C. Crawford , Frank M. Bogun , Xiaokui Gu , Kenneth A. Ellenbogen , Alexandra B. Chicos , Henri Roukoz , Peter J. Zimetbaum , Steven J. Kalbfleisch , Francis D. Murgatroyd , David A. Steckman , Lynda E. Rosenfeld , Ann C. Garlitski , Kyoko Soejima , Adarsh K. Bhan , Vasanth Vedantham , Timm M. Dickfeld , David B. De Lurgio , Pyotr G. Platonov , Matthew M. Zipse , Suguru Nishiuchi , Matthew L. Ortman , Calambur Narasimhan , Kris K. Patton , David G. Rosenthal , Siddharth S. Mukerji , Jarieke C. Hoogendoorn , Katja Zeppenfeld , William H. Sauer , Jordana Kron (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. (Journal of the American Heart Association)
• 12:29
  Reliability of Past Medical History in a Single Hospital Participating in Get With The Guidelines?Stroke Registry - Christopher G. Favilla, Alice F. Ford , Ossama Khazaal , Daniel Cristancho , Emily Grodinsky , Judy Dawod , and Scott E. Kasner 1Department of Neurology University of Pennsylvania Philadelphia PA J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundThe GWTG (Get With The Guidelines)?Stroke registry supports clinical research and quality improvement projects that often rely on past medical history elements, the reliability of which remains largely unknown. Here, we (...) (Journal of the American Heart Association)
• 12:29
  Extended Anticoagulation After Pulmonary Embolism: A Multicenter Observational Cohort Analysis - Romain Chopard, Ida Ehlers Albertsen , Fiona Ecarnot , Sebastien Guth , Matthieu Besutti , Nicolas Falvo , Gregory Piazza , and Nicolas Meneveau 1Department of Cardiology University Hospital Jean Minjoz Besançon France 2EA3920 University of Burgundy Franche?Comté Besançon France 3F?CRIN INNOVTE Network Saint?Etienne France 4Aalborg Thrombosis Research Unit Aalborg University Hospital Aalborg Denmark 5Department of Internal Medicine University Hospital Dijon?Bourgogne Dijon France 6Division of Cardiovascular Medicine Department of Medicine Brigham and Women’s HospitalHarvard Medical School (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundPulmonary embolism (PE) has a long?term risk of adverse events, which can be prevented by extended anticoagulation. We compared clinical characteristics and outcomes between patients treated with 2?year extended anticoagulation (...) (Journal of the American Heart Association)
• 12:28
  Increases in Circulating and Fecal Butyrate are Associated With Reduced Blood Pressure and Hypertension: Results From the SPIRIT Trial - Curtis Tilves, Hsin?Chieh Yeh , Nisa Maruthur , Stephen P. Juraschek , Edgar Miller , Karen White , Lawrence J. Appel , and Noel T. Mueller 1Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore MD 2Welch Center for Prevention, Epidemiology, and Clinical Research Johns Hopkins University Baltimore MD 3Division of General Medicine and Primary Care Beth Israel Deaconess Medical Center Boston MA J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundShort chain fatty acids (SCFAs) are microbially derived end products of dietary fiber fermentation. The SCFA butyrate reduces blood pressure (BP) in mouse models. The association of SCFAs, including butyrate, with BP in humans (...) (Journal of the American Heart Association)
• 12:28
  Myocardial Injury in Patients With Acute and Subacute Chagas Disease in the Brazilian Amazon Using Cardiovascular Magnetic Resonance - Katia do Nascimento Couceiro, Jessica Vanina Ortiz , Mônica Regina Hosannah da Silva e Silva , Débora Raysa Teixeira de Sousa , Rubens Celso Andrade , Alba Regina Jorge Brandão , Rômulo Freire de Morais , Susan Smith Doria , Rafael Almeida Fonseca , Paula Rita Leite da Silva , Fabio Fernandes , Maria das Graças Vale Barbosa Guerra , Carlos Eduardo Rochitte , João Marcos Bemfica Barbosa Ferreira , and Jorge Augusto de Oliveira Guerra 1Programa de Pós?Graduação em Medicina Tropical–Universidade do Estado do Amazonas Manaus Amazonas Brazil 2Universidade Nilton Lins Manaus Amazonas Brazil 3Instituto do (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundChagas disease is a neglected tropical disease that is still considered a global health emergency. In the Amazon region, most of the reports are of acute cases that are associated with oral transmission. This study aimed to (...) (Journal of the American Heart Association)
• 12:31
  Genetically?Proxied Levels of Vitamin D and Risk of Intracerebral Hemorrhage - Natalia Szejko, Julian N. Acosta , Cameron P. Both , Audrey Leasure , Charles Matouk , Lauren Sansing , Thomas M. Gill , Zhao Hongyu , Kevin Sheth , and Guido J. Falcone 1 Department of Neurology Yale School of Medicine New Haven CT 2 Department of Bioethics Medical University of Warsaw Poland 3 Department of Neurology Medical University of Warsaw Poland 4 Department of Neurosurgery Yale School of Medicine New Haven CT 5 Department of Internal Medicine, Geriatric Medicine Yale School of Medicine New Haven CT 6 Department of Biostatistics Yale School of Public Health New Haven (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundThe evidence linking vitamin D (VitD) levels and spontaneous intracerebral hemorrhage (ICH) remains inconclusive. We tested the hypothesis that lower genetically determined VitD levels are associated with higher risk of (...) (Journal of the American Heart Association)

Hypertension https://www.ahajournals.org/

• 11:00
  Voluntary Exercise Eliminates Maternal Gestational Hypertension–Induced Hypertensive Response Sensitization to Postweaning High-Fat Diet in Male Adult Offspring - Baojian Xue Yang Yu Terry G. Beltz Fang Guo Shun-Guang Wei Alan Kim Johnson Departments of Psychological and Brain Sciences, University of Iowa, Iowa City. (B.X., T.G.B., F.G., A.K.J.) Neuroscience and Pharmacology, University of Iowa, Iowa City. (A.K.J.) Health and Human Physiology, University of Iowa, Iowa City. (A.K.J.) Internal Medicine, University of Iowa, Iowa City. (Y.Y., S.-G.W.) the François M. Abboud Cardiovascular Research Center, University of Iowa, Iowa City. (S.-G.W., (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Exercise has profound effects on cardiovascular function and metabolism in both physiological and pathophysiological states. The present study tested whether voluntary exercise would protect male offspring against maternal gestational (...) (Hypertension)

Kidney Int http://www.kidney-international.org/

• 00:00
  Results from a national-wide retrospective cohort measure the impact of C3 and soluble C5b-9 levels on kidney outcomes in C3 glomerulopathy. - Sophie Chauvet, Jill J. Hauer, Florent Petitprez, Marion Rabant, Paula Vieira Martins, Véronique Baudouin, Yahsou Delmas, Noémie Jourde-Chiche, Alexandre Cez, David Ribes, Sylvie Cloarec, Aude Servais, Mohamad Zaidan, Eric Daugas, Michel Delahousse, Alain Wynckel, Amélie Ryckewaert, Anne Laure Sellier-Leclerc, Olivia Boyer, Eric Thervet, Alexandre Karras, Richard J.H. Smith, Véronique Frémeaux-Bacchi Kidney Int
  C3 glomerulopathy (C3G) is a rare complement-mediated disease. Specific treatments are not yet available and factors predictive of kidney survival such as age, kidney function and proteinuria are not specific to C3G. The prognostic value of biomarkers of complement activation, which are (...) (Kidney International (2022))
• 00:00
  Insulin-like growth factor binding protein 7 promotes acute kidney injury by alleviating poly ADP ribose polymerase 1 degradation. - Ju-tao Yu, Xiao-wei Hu, Qin Yang, Run-run Shan, Yao Zhang, Ze-hui Dong, Hai-di Li, Jia-nan Wang, Chao Li, Shuai-shuai Xie, Yu-hang Dong, Wei-jian Ni, Ling Jiang, Xue-qi Liu, Biao Wei, Jia-gen Wen, Ming-ming Liu, Qi Chen, Ya-ru Yang, Gui-yang Zhang, Hong-mei Zang, Juan Jin, Yong-gui Wu, Xiang Zhong, Jun Li, Wei Wang, Xiao-ming Meng Kidney Int
  The novel biomarker, insulin-like growth factor binding protein 7 (IGFBP7), is used clinically to predict different types of acute kidney injury (AKI) and has drawn significant attention as a urinary biomarker. However, as a secreted protein in the circulation of patients with AKI, it is (...) (Kidney International (2022))
• 00:00
  Azithromycin use increases the risk of sudden cardiac death in patients with hemodialysis-dependent kidney failure. - Magdalene M. Assimon, Patrick H. Pun, Lily Wang, Sana M. Al-Khatib, M. Alan Brookhart, David J. Weber, Wolfgang C. Winkelmayer, Jennifer E. Flythe Kidney Int
  Azithromycin is an antibiotic with QT-prolonging potential commonly prescribed to individuals receiving hemodialysis. Hemodialysis patients have a high prevalence of clinical conditions, such as structural heart disease, that can enhance the pro-arrhythmic effects azithromycin, but were (...) (Kidney International (2022))

Diabetologia http://link.springer.com/

• 00:00
  The role of mental disorders in precision medicine for diabetes: a narrative review Diabetologia
  Abstract This narrative review aims to examine the value of addressing mental disorders as part of the care of people with type 1 and type 2 diabetes in terms of four components of precision medicine. First, we review the empirical literature on the role of common mental disorders in the (...)

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Role of the cGAS–STING pathway in systemic and organ-specific diseases - Sladjana Skopelja-Gardner, Jie An, Keith B. Elkon Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 22 June 2022; doi:10.1038/s41581-022-00589-6The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway not only is involved in host defence against infection but can lead to immune dysregulation. Here, the authors examine the (...) (Nature Reviews Nephrology, Published online: 2022-06-22; | doi:10.1038/s41581-022-00589-6)

21 June

Stroke https://www.ahajournals.org/

• 11:00
  Polypill: Benefits Seen for Stroke and Other Outcomes - Michael Brainin Yvonne Teuschl Sheila Martins Department for Clinical Neuroscience and Preventive Medicine, University for Continuing Education Krems, Austria (M.B., Y.T.). Neurology and Neurosurgery Service, Hospital Moinhos de Vento, Brazil (S.M.). Neurology Service, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (S.M.). Stroke
  Stroke, Ahead of Print. A polypill-type strategy for primary prevention was first published at the turn of the century and advised that a multi-ingredient pill applied to an adult population would prevent up to 80% of cardiovascular and stroke events. Such a pill should contain small doses of (...) (Stroke)

Hypertension https://www.ahajournals.org/

• 11:00
  Cathepsin K Deficiency Prevented Kidney Damage and Dysfunction in Response to 5/6 Nephrectomy Injury in Mice With or Without Chronic Stress - Xueling Yue Limei Piao Hailong Wang Zhe Huang Xiangkun Meng Takeshi Sasaki Aiko Inoue Kae Nakamura Ying Wan Shengnan Xu Guo-Ping Shi Weon Kim Toyoaki Murohara Masafumi Kuzuya Xian Wu Cheng Department of Cardiology and Hypertension, Yanbian University Hospital, Yanji, Jilin, People's Republic of China (X.Y., L.P., H.W., Z.H., X.M., Y.W., S.X., X.W.C.). Department of Community Health Care and Geriatrics, Nagoya University Graduate School of Medicine, Japan. (X.Y., Z.H., X.M., M.K.) Institute of Innovation for Future Society, Nagoya University Graduate School of Medicine, Japan. (A.I., M.K.) (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Chronic psychological stress is a risk factor for kidney disease, including kidney dysfunction and hypertension. Lysosomal CatK (cathepsin K) participates in various human pathobiologies. We investigated the role of CatK in kidney remodeling and (...) (Hypertension)
• 11:00
  Digital Therapeutics in Hypertension: Evidence and Perspectives - Kazuomi Kario Noriko Harada Ayako Okura Division of Cardiovascular Medicine, School of Medicine, Jichi Medical University, Tochigi, Japan. Hypertension
  Hypertension, Ahead of Print. Digital therapeutics refers to the use of evidence-based therapeutic interventions driven by high-quality software programs to treat, manage, or prevent a medical condition. This approach is being increasingly investigated for the management of hypertension, a (...) (Hypertension)

Circulation http://ahajournals.org/

• 11:00
  Association of Extreme Heat and Cardiovascular Mortality in the United States: A County-Level Longitudinal Analysis From 2008 to 2017 - Sameed Ahmed M. Khatana Rachel M. Werner Peter W. Groeneveld Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia. (S.A.M.K.) Penn Cardiovascular Outcomes, Quality, & Evaluative Research Center, University of Pennsylvania, Philadelphia. (S.A.M.K., P.W.G.) Division of General Internal Medicine, University of Pennsylvania, Philadelphia. (R.M.W., P.W.G.) Perelman School of Medicine, and The Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia. (S.A.M.K., R.M.W., P.W.G.) Center for Health Equity Research and Promotion, Michael J. (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Extreme-heat events are increasing as a result of climate change. Prior studies, typically limited to urban settings, suggest an association between extreme heat and cardiovascular mortality. However, the extent of the burden of cardiovascular deaths (...) (Circulation)
• 11:00
  Cost-Effectiveness of Catheter Ablation Versus Antiarrhythmic Drug Therapy in Atrial Fibrillation: The CABANA Randomized Clinical Trial - Derek S. Chew Yanhong Li Patricia A. Cowper Kevin J. Anstrom Jonathan P. Piccini Jeanne E. Poole Melanie R. Daniels Kristi H. Monahan Linda Davidson-Ray Tristram D. Bahnson Hussein R. Al-Khalidi Kerry L. Lee Douglas L. Packer Daniel B. Mark Duke Clinical Research Institute, Duke University, Durham, NC. (D.S.C., Y.L., P.A.C., K.J.A., J.P.P., M.R.O., L.D.-R., T.D.B., H.R.A.-K., K.L.L., D.L.P., D.B.M.) Department of Biostatistics and Bioinformatics (K.J.A., H.R.A.-K., K.L.L.) Department of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary, Alberta, Canada (D.S.C.). (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:In the CABANA trial (Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation), catheter ablation did not significantly reduce the primary end point of death, disabling stroke, serious bleeding, or cardiac arrest compared with drug therapy (...) (Circulation)
• 10:24
  Around and Around…A Wide Complex Tachycardia - Ricardo Avendaño Nimrod Lavi Lynda E. Rosenfeld Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT. Circulation
  Circulation, Volume 145, Issue 25, Page 1867-1869, June 21, 2022. (Circulation)
• 10:24
  Rivaroxaban 2.5 mg Twice Daily Plus Aspirin Reduces Venous Thromboembolism in Patients With Chronic Atherosclerosis - Nana Pogosova Jacqueline Bosch Deepak L. Bhatt Keith A.A. Fox Stuart J. Connolly Marco Alings Peter Verhamme Eva Muehlhofer Olga Shestakovska Salim Yusuf John W. Eikelboom National Medical Research Centre of Cardiology, Moscow, Russia (N.P.). Population Health Research Institute, Hamilton, Ontario, Canada (J.P., S.J.C., O.S., S.Y., J.W.E.). McMaster University, Hamilton, Ontario, Canada (J.P., S.J.C., S.Y., J.W.E.). Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, (D.L.B.). Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (K.A.A.F.). Hamilton (...) Circulation
  Circulation, Volume 145, Issue 25, Page 1875-1877, June 21, 2022. (Circulation)
• 10:24
  First Pig-to-Human Heart Transplant Marks a Milestone in Xenotransplantation - Bridget M. Kuehn Circulation
  Circulation, Volume 145, Issue 25, Page 1870-1871, June 21, 2022. (Circulation)
• 10:24
  Allograft Rejection Surveillance In Heart Transplantation: Is There a Better Way? - James C. Fang Omar Wever-Pinzon University of Utah Health Sciences Center, Salt Lake City. Circulation
  Circulation, Volume 145, Issue 25, Page 1825-1828, June 21, 2022. (Circulation)
• 10:24
  Can Early Ablation of Ventricular Tachycardia Improve Survival? - Arvindh N. Kanagasundram Travis D. Richardson William G. Stevenson Cardiovascular Division, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN. Circulation
  Circulation, Volume 145, Issue 25, Page 1850-1852, June 21, 2022. (Circulation)

Diabetologia http://link.springer.com/

• 00:00
  Up Front Diabetologia
• 00:00
  Precision prognostics for the development of complications in diabetes Diabetologia
  Abstract Individuals with diabetes face higher risks for macro- and microvascular complications than their non-diabetic counterparts. The concept of precision medicine in diabetes aims to optimise treatment decisions for individual patients to reduce the risk of major diabetic complications, (...)

Eur Heart J https://academic.oup.com/site_5375/

• 02:00
  Antiplatelet treatment of acute coronary syndromes: novel clinical and translational perspectives - Crea F. Eur Heart J

20 June

Kidney Int http://www.kidney-international.org/

• 00:00
  Snapshots of nascent RNA can validate different nephron segment responses in acute kidney injury: a step toward clinically useful biomarkers? - Motonobu Nakamura, Masaomi Nangaku Kidney Int
  Acute kidney injury (AKI) is an organ damage syndrome that occurs in response to a variety of types of injury. Across a spectrum of clinical severity and pathologic damage, AKI is associated with poor prognosis. Tubular epithelial cells respond to injury and start the repair process within (...) (Kidney International (2022))
• 00:00
  Modelling AKI in vitro: taking organoids to the next level - Letizia De Chiara, Yun Xia Kidney Int
  Repeated episodes of acute kidney injury (AKI) can lead to chronic kidney disease (CKD). The proximal tubule (PT) is particularly vulnerable to injury because it plays a crucial metabolic role in the handling of drugs, nephrotoxins, metabolites, and signaling molecules. Despite some (...) (Kidney International (2022))

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

• 12:02
  From Purpose to Impact: Harnessing the Elements to Improve Peripheral Artery Disease Outcomes - Subhash Banerjee, Lawrence Hoang , and Douglas E. Drachman 1University of Texas Southwestern Medical Center Dallas TX 2Methodist Hospital Dallas TX 3Massachusetts General Hospital Boston MA J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. (Journal of the American Heart Association)
• 12:02
  Cardiovascular and Limb Events Following Endovascular Revascularization Among Patients ?65 Years Old: An American College of Cardiology PVI Registry Analysis - E. Hope Weissler, Yongfei Wang , Jordan M. Gales , Dmitriy N. Feldman , Shipra Arya , Eric A. Secemsky , Herbert D. Aronow , Beau M. Hawkins , J. Antonio Gutierrez , Manesh R. Patel , Jeptha P. Curtis , W. Schuyler Jones , and Rajesh V. Swaminathan 1Division of Vascular and Endovascular Surgery Department of Surgery Duke University School of Medicine Durham NC 2Section of Cardiovascular Medicine Department of Internal Medicine Yale School of Medicine New Haven CT 3Center of Outcome Research and Evaluation Yale?New Haven Health Services New Haven CT 4Texas Heart Institute Houston TX (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundWe aimed to characterize the occurrence of major adverse cardiovascular and limb events (MACE and MALE) among patients with peripheral artery disease (PAD) undergoing peripheral vascular intervention (PVI), (...) (Journal of the American Heart Association)
• 12:01
  Moving Beyond Self?Reported Race in Our Understanding of Cardiovascular Medicine - Nancy Luo 1Sutter Heart and Vascular Institute Sacramento CA J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. (Journal of the American Heart Association)
• 12:01
  A Frequentist Opting for the Road Less Traveled - Mirvat Alasnag, and Mamas A. Mamas 1Cardiac Center King Fahd Armed Forces Center Jeddah Saudi Arabia 2Keele Cardiovascular Research Group Keele University Stoke on Trent United Kingdom J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. (Journal of the American Heart Association)
• 12:01
  When the Price Is Right: Beyond the Medical Risks and Benefits of Costly Therapies - Michelle M. Kittleson 1Department of Cardiology Smidt Heart InstituteCedars?Sinai Medical Center Los Angeles CA J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. (Journal of the American Heart Association)
• 12:01
  Impact of Financial Considerations on Willingness to Take Sacubitril/Valsartan for Heart Failure - Birju R. Rao, Candace D. Speight , Larry A. Allen , Scott D. Halpern , Yi?An Ko , Daniel D. Matlock , Miranda A. Moore , Alanna A. Morris , Laura D. Scherer , Mary C. Thomson , Peter Ubel , and Neal W. Dickert 1Division of Cardiology Department of Medicine Emory University School of Medicine Atlanta GA 2Department of Medicine University of Colorado School of Medicine Aurora CO 3Palliative and Advanced Illness Research (PAIR) Center and Department of Medicine Pennsylvania Perelman School of Medicine Philadelphia PA 4Department of Biostatistics Emory University Rollins School of Public (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundSacubitril/valsartan improves health outcomes for heart failure with reduced ejection fraction relative to angiotensin?converting enzyme inhibitors or angiotensin receptor blockers, but it carries higher (...) (Journal of the American Heart Association)
• 12:00
  Systematic Review and Network Meta?Analysis Comparing Bifurcation Techniques for Percutaneous Coronary Intervention - Dae Yong Park, Seokyung An , Neeraj Jolly , Steve Attanasio , Neha Yadav , Sunil Rao , and Aviral Vij 1Department of Medicine John H. Stroger Jr Hospital of Cook County Chicago IL 2Department of Biomedical Science Seoul National University Graduate School Seoul Korea 3Division of Cardiology Rush University Medical Center Chicago IL 4Division of Cardiology Cook County Health Chicago IL 5Division of Cardiology Rush Medical College Chicago IL 6Duke Clinical Research Institute and Duke University Health System Durham (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundBifurcation lesions account for 20% of all percutaneous coronary interventions and represent a complex subset which are associated with lower procedural success and higher rates of restenosis. The ideal (...) (Journal of the American Heart Association)
• 12:00
  Angiotensin Receptor Neprilysin Inhibition and Associated Outcomes by Race and Ethnicity in Patients With Heart Failure With Reduced Ejection Fraction: Data From CHAMP?HF - Brittany Chapman, Anne S. Hellkamp , Laine E. Thomas , Nancy M. Albert , Javed Butler , J. Herbert Patterson , Adrian F. Hernandez , Fredonia B. Williams , Xian Shen , John A. Spertus , Gregg C. Fonarow , and Adam D. DeVore 1Department of Medicine Duke University School of Medicine Durham NC 2Duke Clinical Research Institute Durham NC 3Cleveland Clinic Cleveland OH 4University of Mississippi Medical Center Jackson MS 5Eshelman School of Pharmacy University of North Carolina Chapel Hill NC 6Mended Hearts Huntsville AL 7Novartis Pharmaceuticals Corporation East Hanover NJ 8Saint Luke’s Mid (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundThere are limited data on the use of angiotensin receptor neprilysin inhibitors (ARNIs) in minority populations with heart failure (HF) with reduced ejection fraction. We used data from the CHAMP?HF (Change (...) (Journal of the American Heart Association)

Stroke https://www.ahajournals.org/

• 11:00
  Nursing Care of the Acute Ischemic Stroke Endovascular Thrombectomy Patient - Michelle Hill J.J. Baumann Nancy Newcommon OhioHealth-Riverside Methodist Hospital, Columbus (M.H.). Calgary Stroke Program, Alberta, Canada (N.N.). UCHealth Memorial Hospital, Colorado Springs, CO (J.J.B.). Stroke
  Stroke, Ahead of Print. Nurses are an integral part of the multidisciplinary team caring for a patient eligible for endovascular thrombectomy. Their care includes obtaining health history, performing clinical assessments, using critical thinking to anticipate the care path, and communicating (...) (Stroke)

Hypertension https://www.ahajournals.org/

• 11:00
  Variation in Mean Arterial Pressure Increases Falls Risk in Elderly Physically Frail and Prefrail Individuals Treated With Antihypertensive Medication - Sultana Monira Hussain Michael E. Ernst Anna L. Barker Karen L. Margolis Christopher M. Reid Johannes T. Neumann Andrew M. Tonkin Thao Le Thi Phuong Lawrence J Beilin Thao Pham Enayet K. Chowdhury Flavia M. Cicuttini Julia Gilmartin-Thomas Prudence R. Carr John J McNeil School of Public Health and Preventive Medicine, Monash University, Victoria, Australia (S.M.H., A.L.B., C.M.R., J.T.N., A.M.T., T.L.T.P., T.P., E.K.C., F.M.C., J.G.-T., P.R.C., J.J.M.). Department of Medical Education, Melbourne Medical School, The University of Melbourne, Victoria, Australia. (S.M.H.) Department of (...) Hypertension
  Hypertension, Ahead of Print. Background:Impaired cerebral blood flow has been associated with an increased risk of falls. Mean arterial pressure (MAP) and variability in MAP have been reported to affect cerebral blood flow but their relationships to the risk of falls have not previously been (...) (Hypertension)

Circulation http://ahajournals.org/

• 11:00
  Cerebral Microbleeds During Transcatheter Aortic Valve Replacement: A Prospective Magnetic Resonance Imaging Cohort - Eric Van Belle Nicolas Debry Flavien Vincent Grégory Kuchcinski Charlotte Cordonnier Antoine Rauch Emmanuel Robin Fanny Lassalle François Pontana Cédric Delhaye Guillaume Schurtz Emmanuelle JeanPierre Natacha Rousse Caterina Casari Hugues Spillemaeker Sina Porouchani Thibault Pamart Tom Denimal Xavier Neiger Basile Verdier Laurent Puy Alessandro Cosenza Francis Juthier Marjorie Richardson Martin Bretzner Jean Dallongeville Julien Labreuche Mikael Mazighi Annabelle Dupont-Prado Bart Staels Peter J. Lenting Sophie Susen Cardiology Department (E.V.B., N.D., F.V., C.D., G.S., H.S., S.P., T.P., (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Cerebral microbleeds (CMBs) have been observed in healthy elderly people undergoing systematic brain magnetic resonance imaging. The potential role of acute triggers on the appearance of CMBs remains unknown. We aimed to describe the incidence of new CMBs (...) (Circulation)

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  The effect of HIF on metabolism and immunity - Cormac T. Taylor, Carsten C. Scholz Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 20 June 2022; doi:10.1038/s41581-022-00587-8Hypoxia-dependent changes in cellular metabolism have important implications for the effective functioning of multiple immune cell subtypes. This Review describes the inputs that shape the hypoxic response (...) (Nature Reviews Nephrology, Published online: 2022-06-20; | doi:10.1038/s41581-022-00587-8)

Diabetologia http://link.springer.com/

• 00:00
  Correction to: Association of gut microbiota with glycaemic traits and incident type 2 diabetes, and modulation by habitual diet: a population-based longitudinal cohort study in Chinese adults Diabetologia

18 June

Diabetologia http://link.springer.com/

• 00:00
  Umbilical cord blood DNA methylation in children who later develop type 1 diabetes Diabetologia
  Abstract Aims/hypothesis Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA methylation is associated with later progression to type 1 diabetes. Methods Reduced (...)

17 June

Kidney Int http://www.kidney-international.org/

• 00:00
  A retrospective cohort study measured predicting and validating the impact of the COVID-19 pandemic in individuals with chronic kidney disease - Ashkan Dashtban, Mehrdad A. Mizani, Spiros Denaxas, Dorothea Nitsch, Jennifer Quint, Richard Corbett, Jil B. Mamza, Tamsin Morris, Mamas Mamas, Deborah A. Lawlor, Kamlesh Khunti, CVD-COVID-UK Consortium, Cathie Sudlow, Harry Hemingway, Amitava Banerjee Kidney Int
  Chronic kidney disease (CKD) is associated with increased risk of baseline mortality and severe COVID-19, but analyses across CKD stages, and comorbidities are lacking. In prevalent and incident CKD, we investigated comorbidities, baseline risk, COVID-19 incidence, and predicted versus observed (...) (Kidney International (2022))

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

• 12:55
  Invasive Versus Medical Management in Patients With Chronic Kidney Disease and Non–ST?Segment–Elevation Myocardial Infarction - Monil Majmundar, Gabriel Ibarra , Ashish Kumar , Rajkumar Doshi , Palak Shah , Roxana Mehran , Grant W. Reed , Rishi Puri , Samir R. Kapadia , Sripal Bangalore , and Ankur Kalra 1Department of Cardiology Maimonides Medical Center, Brooklyn New York NY 2Department of Internal Medicine Brown University Providence RI 3Department of Internal Medicine Cleveland Clinic Akron General Akron OH 4Division of Cardiology St. Joseph’s University Medical Center Paterson NJ 5Department of Internal Medicine New York Medical College/Metropolitan Hospital New York NY 6The Zena and Michael A. Wiener (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundThe role of invasive management compared with medical management in patients with non–ST?segment–elevation myocardial infarction (NSTEMI) and advanced chronic kidney disease (CKD) is uncertain, given the (...) (Journal of the American Heart Association)
• 12:54
  Invasive Management for Non–ST?Segment–Elevation Myocardial Infarction and Chronic Kidney Disease: Does One Size Fit All? - Ayman Elbadawi, Islam Y. Elgendy , and Paul Kumfa 1 Section of Cardiology Baylor College of Medicine Houston TX 2 Division of Cardiology University of Texas Southwestern Medical Center Dallas TX 3 Division of Cardiovascular Medicine Gill Heart Institute, University of Kentucky Lexington KY 4 Division of Cardiology University of Texas Medical Branch Galveston TX J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. (Journal of the American Heart Association)

Stroke https://www.ahajournals.org/

• 11:00
  Understanding of the Lower Extremity Motor Recovery After First-Ever Ischemic Stroke - Hyun Haeng Lee Min Kyun Sohn Deog Young Kim Yong-Il Shin Gyung-Jae Oh Yang-Soo Lee Min Cheol Joo So Young Lee Min-Keun Song Junhee Han Jeonghoon Ahn Young-Hoon Lee Won Hyuk Chang Soo Mi Choi Seon Kui Lee Jongmin Lee Yun-Hee Kim Department of Rehabilitation Medicine, Konkuk University Medical Center and Konkuk University School of Medicine, Seoul, South Korea (H.H.L., J.L.). Department of Rehabilitation Medicine, Chungnam National University School of Medicine, Daejeon, South Korea (M.K.S.). Department and Research Institute of Rehabilitation Medicine, Yonsei University College of (...) Stroke
  Stroke, Ahead of Print. Background:We aimed to verify the validity of the proportional recovery model for the lower extremity.Methods:We reviewed clinical data of patients enrolled in the Korean Stroke Cohort for Functioning and Rehabilitation between August 2012 and May 2015. Recovery (...) (Stroke)

Circulation http://ahajournals.org/

• 11:00
  Frequency of Screening-Detected Intracranial Aneurysms in Patients With Loeys-Dietz Syndrome - Anna L. Huguenard Gabrielle W. Johnson Joshua W. Osbun Ralph G. Dacey Alan C. Braverman Department of Neurosurgery, Washington University School of Medicine, St. Louis, MO. (A.L.H., G.W.J., J.W.O., R.G.D.) Department of Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO. (A.C.B.) Circulation
  Circulation, Ahead of Print. (Circulation)

16 June

Kidney Int http://www.kidney-international.org/

• 00:00
  Neutrophil gelatinase-associated lipocalin is elevated in children with acute kidney injury and sickle cell anemia, and predicts mortality - Anthony Batte, Sahit Menon, John M. Ssenkusu, Sarah Kiguli, Robert Kalyesubula, Joseph Lubega, Zachary Berrens, Edrisa Ibrahim Mutebi, Rodney Ogwang, Robert O. Opoka, Chandy C. John, Andrea L. Conroy Kidney Int
  Urine neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury that has been adapted to a urine dipstick test. However, there is limited data on its use in low-and-middle-income countries where diagnosis of acute kidney injury remains a challenge. To study this, (...) (Kidney International (2022))

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

• 17:32
  Blood pressure variability and the development of hypertensive organ damage in the general population - Tomonori Sugiura, Hiroyuki Takase, Masashi Machii, Kazusa Hayashi, Suguru Nakano, Shin Takayama, Yoshihiro Seo, Yasuaki Dohi J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

• 14:33
  Trends, Predictors, and Outcomes of Cardiovascular Complications Associated With Polycystic Ovary Syndrome During Delivery Hospitalizations: A National Inpatient Sample Analysis (2002–2019) - Salman Zahid, Muhammad Zia Khan , Smitha Gowda , Nadeen N. Faza , Michael C. Honigberg , Arthur (Jason) Vaught , Carolyn Guan , Anum S. Minhas , and Erin D. Michos 1 Sands?Constellation Heart Institute Rochester General Hospital Rochester NY 2 Division of Cardiovascular Medicine West Virginia University Heart and Vascular Institute Morgantown WV 3 Division of Cardiology Houston Methodist DeBakey Heart and Vascular Center Houston TX 4 Cardiology Division, Department of Medicine Massachusetts General Hospital Boston MA 5 Division of Maternal Fetal Medicine, Department of Gynecology and (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundWomen with polycystic ovary syndrome (PCOS) have an increased risk of pregnancy?associated complications. However, data on peripartum cardiovascular complications remain limited. Hence, we investigated trends, outcomes, and (...) (Journal of the American Heart Association)

Hypertension https://www.ahajournals.org/

• 11:00
  Effects of a Liquefied Petroleum Gas Stove Intervention on Gestational Blood Pressure: Intention-to-Treat and Exposure-Response Findings From the HAPIN Trial - Wenlu Ye Kyle Steenland Ashlinn Quinn Jiawen Liao Kalpana Balakrishnan Ghislaine Rosa Florien Ndagijimana Jean de Dieu Ntivuguruzwa Lisa M. Thompson John P. McCracken Anaité Díaz-Artiga Joshua P. Rosenthal Aris Papageorghiou Victor G. Davila-Roman Ajay Pillarisetti Michael Johnson Jiantong Wang Laura Nicolaou William Checkley Jennifer L. Peel Thomas F. Clasen Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA. (W.Y., K.S., A. Pillarisetti, T.F.C.) Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA. (L.M.T.) (...) Hypertension
  Hypertension, Ahead of Print. Background:Approximately 3 to 4 billion people worldwide are exposed to household air pollution, which has been associated with increased blood pressure (BP) in pregnant women in some studies.Methods:We recruited 3195 pregnant women in Guatemala, India, Peru, and (...) (Hypertension)
• 11:00
  Revascularization for Renovascular Disease: A Scientific Statement From the American Heart Association - Vivek Bhalla Stephen C. Textor Joshua A. Beckman Ana I. Casanegra Christopher J. Cooper Esther S.H. Kim James M. Luther Sanjay Misra Gustavo S. Oderich Hypertension
  Hypertension, Ahead of Print. Renovascular disease is a major causal factor for secondary hypertension and renal ischemic disease. However, several prospective, randomized trials for atherosclerotic disease failed to demonstrate that renal revascularization is more effective than medical (...) (Hypertension)

Circulation http://ahajournals.org/

• 11:00
  Frequency, Penetrance, and Variable Expressivity of Dilated Cardiomyopathy–Associated Putative Pathogenic Gene Variants in UK Biobank Participants - Ravi A. Shah Babken Asatryan Ghaith Sharaf Dabbagh Nay Aung Mohammed Y. Khanji Luis R. Lopes Stefan van Duijvenboden Anthony Holmes Daniele Muser Andrew P. Landstrom Aaron Mark Lee Pankaj Arora Christopher Semsarian Virend K. Somers Anjali T. Owens Patricia B. Munroe Steffen E. Petersen C. Anwar A. Chahal Imperial College Healthcare NHS Trust, London, United Kingdom (R.A.S.). Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (B.A.). Center for Inherited Cardiovascular Diseases, WellSpan Health, Lancaster, PA (G.S.D., C.A.A.C.). University of (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:There is a paucity of data regarding the phenotype of dilated cardiomyopathy (DCM) gene variants in the general population. We aimed to determine the frequency and penetrance of DCM-associated putative pathogenic gene variants in a general adult (...) (Circulation)

Am J Hypertens https://academic.oup.com/

• 02:00
  From the Editor-in-Chief: Issue at a Glance - Schiffrin E. Am J Hypertens
  This June 2022 Issue at a Glance of the American Journal of Hypertension will be the last of these introductory articles that we will be publishing in the Journal. We will move to another format, since the lateness of the Issue at a Glance has created production delays, especially associated (...)
• 02:00
  Effects of Hypertension on the Incidence of Acute Coronary Syndrome and Severity of Coronary Artery Disease in Young Women - Liu R, Xu F, Liu T, et al. Am J Hypertens
  AbstractBackgroundTo investigate the effects of hypertension on the prevalence of acute coronary syndrome (ACS) and the severity of coronary artery disease in young women in northern China.MethodsA retrospective analysis was performed on 840 young female patients (age ResultsThe prevalence of (...)
• 02:00
  Correlation of 24-Hour Urinary Microalbumin and Atrial Arrhythmia in Patients With Essential Hypertension - Naderemu P, Zhang J, Liu H, et al. Am J Hypertens
  AbstractBackgroundTo investigate the relationship between 24-hour urinary microalbumin (24h-UmAlb) and atrial arrhythmia in patients with essential hypertension (EH).MethodsFrom March 2018 to January 2020, 917 EH patients at First Affiliated Hospital of Xinjiang Medical University were (...)

Diabetologia http://link.springer.com/

• 00:00
  A miR-125/Sirtuin-7 pathway drives the pro-calcific potential of myeloid cells in diabetic vascular disease Diabetologia
  Abstract Aims/hypothesis Ectopic calcification is a typical feature of diabetic vascular disease and resembles an accelerated ageing phenotype. We previously found an excess of myeloid calcifying cells in diabetic individuals. We herein examined molecular and cellular pathways linking (...)
• 00:00
  Exploring ethnic representativeness in diabetes clinical trial enrolment from 2000 to 2020: a chronological survey Diabetologia
  Abstract Aims/hypothesis Ethnic representativeness of participant enrolment in diabetes RCTs involving multiple ethnicities remains unknown. The aims of this study were to evaluate the status and temporal trend of ethnic representativeness in enrolment to diabetes RCTs, and to assess (...)

Hypertension https://www.ahajournals.org/

• 06:00
  Control of Blood Pressure and Risk of Cardiovascular Disease and Mortality in Elderly Chinese: A Real-World Prospective Cohort Study - Anxin Wang Xue Tian Yingting Zuo Shuohua Chen Yijun Zhang Xiaoli Zhang Xuan Deng Qin Xu Penglian Wang Shouling Wu Yong Zhou Department of Neurology, Beijing Tiantan Hospital (A.W., X.T., Y. Zuo, Y. Zhang, X.Z., Q.X., P.W.) China National Clinical Research Center for Neurological Diseases (A.W., X.T., Y. Zuo, Y. Zhang, X.Z., Q.X., P.W.) Department of Epidemiology and Health Statistics, School of Public Health (X.T., Y. Zuo) Capital Medical University. Beijing Municipal Key Laboratory of Clinical Epidemiology, China (X.T., Y. Zuo). Department of Cardiology, Kailuan Hospital, North China (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:The STEP trial (Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients) showed that older hypertensive patients might benefit from a target systolic blood pressure (SBP) of 110 (...) (Hypertension)

15 June

Kidney Int http://www.kidney-international.org/

• 00:00
  Proximal-tubule molecular relay from early Protein diaphanous homolog 1 to late Rho-associated protein kinase 1 regulates kidney function in obesity-induced kidney damage - Makiko Ida-Naitoh, Hirobumi Tokuyama, Koji Futatsugi, Marie Yasuda, Keika Adachi, Takeshi Kanda, Yoshiyuki Tanabe, Shu Wakino, Hiroshi Itoh Kidney Int
  The small GTPase protein RhoA has two effectors, ROCK (Rho-associated protein kinase 1) and mDIA1 (protein diaphanous homolog 1), which cooperate reciprocally. However, temporal regulation of RhoA and its effectors in obesity-induced kidney damage remains unclear. Here, we investigated the role (...) (Kidney International (2022))
• 00:00
  A novel nanoluciferase transgenic reporter measures proteinuria in zebrafish - Richard W. Naylor, Emmanuel Lemarie, Anthony Jackson-Crawford, J. Bernard Davenport, Aleksandr Mironov, Martin Lowe, Rachel Lennon Kidney Int
  The zebrafish is an important animal system for modeling human diseases. This includes kidney dysfunction as the embryonic kidney (pronephros) shares considerable molecular and morphological homology with the human nephron. A key clinical indicator of kidney disease is proteinuria, but a (...) (Kidney International (2022))
• 00:00
  A population cohort analysis of English transplant centers indicates major adverse cardiovascular events after kidney transplantation - Benjamin Anderson, Muhammad Qasim, Felicity Evison, Suzy Gallier, Jonathan N. Townend, Charles J. Ferro, Adnan Sharif Kidney Int
  Major adverse cardiovascular event (MACE) rates immediately after kidney transplantation remain uncertain due to heterogeneous reporting in the literature. To clarify this, we retrospectively studied every eligible kidney transplant procedure performed in England between April 1, 2002 and March (...) (Kidney International (2022))

Stroke https://www.ahajournals.org/

• 11:00
  Functional Outcomes of Patients ?85 Years With Acute Ischemic Stroke Following EVT: A HERMES Substudy - Rosalie V. McDonough Johanna M. Ospel Bruce C.V. Campbell Michael D. Hill Jeffrey L. Saver Diederik W.J. Dippel Andrew M. Demchuk Charles B.L.M. Majoie Scott B. Brown Peter J. Mitchell Serge Bracard Francis Guillemin Tudor G. Jovin Keith W. Muir Philip White Mayank Goyal Department of Diagnostic Imaging (R.V.M., J.M.O.), Foothills Medical Center, University of Calgary, AB, Canada. Department of Clinical Neurosciences (M.D.H., A.M.D., M.G.), Foothills Medical Center, University of Calgary, AB, Canada. Department of Diagnostic and Interventional Neuroradiology, University Medical Center (...) Stroke
  Stroke, Volume 53, Issue 7, Page 2220-2226, July 1, 2022. Background:Observational studies have shown endovascular treatment (EVT) for acute ischemic stroke to be effective in the elderly, despite resulting in poorer outcomes and higher rates of mortality compared with younger patients. (...) (Stroke)
• 11:00
  Is Endovascular Thrombectomy for the Very Elderly? - Claire J. Creutzfeldt Michael R. Levitt Thabele M. Leslie-Mazwi Department of Neurology (C.J.C., T.M.L.-M.), University of Washington, Seattle. Department of Neurological Surgery (M.R.L.), University of Washington, Seattle. Cambia Palliative Care Center of Excellence (C.J.C.), University of Washington, Seattle. Harborview Medical Center, Seattle, WA (C.J.C., M.R.L., T.M.L.-M.). Stroke
  Stroke, Volume 53, Issue 7, Page 2227-2229, July 1, 2022. (Stroke)

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

• 13:08
  Association of Common and Rare Genetic Variation in the 3?Hydroxy?3?Methylglutaryl Coenzyme A Reductase Gene and Cataract Risk - Jonas Ghouse, Gustav Ahlberg , Anne Guldhammer Skov , Henning Bundgaard , and Morten S. Olesen 1Laboratory for Molecular Cardiology Department of Cardiology Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark 2Laboratory for Molecular Cardiology Department of Biomedical Sciences University of Copenhagen Denmark 3Department of Ophthalmology Copenhagen University HospitalRigshospitalet?GlostrupUniversity of Copenhagen Denmark 4Department of Cardiology Copenhagen University Hospital, RigshospitaletUniversity of Copenhagen (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundResults from animal models and observational studies have raised concerns regarding the potential cataractogenic effects of statin treatment. We investigated whether common and rare genetic variants (...) (Journal of the American Heart Association)

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

• 09:34
  Atrial fibrillation and 24?h ambulatory blood pressure pattern - Willem J. Verberk J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- COMMENTARY (Wiley: The Journal of Clinical Hypertension: Table of Contents)

Stroke https://www.ahajournals.org/

• 11:00
  Patient-Centered Outcomes in a Randomized Trial Investigating a Multimodal Prevention Program After Transient Ischemic Attack or Minor Stroke: The INSPiRE-TMS Trial - Thomas Ihl Michael Ahmadi Inga Laumeier Maureen Steinicke Caroline Ferse Philipp Klyscz Matthias Endres Sidsel Hastrup Holger Poppert Frederick Palm Farid I. Kandil Joachim E. Weber Paul von Weitzel-Mudersbach Martin L.J. Wimmer Heinrich J. Audebert Klinik und Hochschulambulanz für Neurologie, Charité–Universitätsmedizin Berlin (T.I., M.A., I.L., M.S., C.F., P.K., M.E., F.I.K., J.E.W., H.J.A.). Center for Stroke Research Berlin, Charité–Universitätsmedizin Berlin, Germany (M.E., H.J.A.). Berlin Institute of Health, Germany (M.A., J.E.W.). ExcellenceCluster NeuroCure (M.E.). German Center for (...) Stroke
  Stroke, Ahead of Print. Background:The INSPiRE-TMS trial (Intensified Secondary Prevention Intending a Reduction of Recurrent Events in Transient Ischemic Attack and Minor Stroke Patients) investigated effects of a multicomponent support program in patients with nondisabling stroke or transient (...) (Stroke)
• 11:00
  Ethical Considerations in Surgical Decompression for Stroke - Nathan A. Shlobin Jeffrey R. Clark Justin M. Campbell Mark Bernstein Babak S. Jahromi Matthew B. Potts Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL. (N.A.S., J.R.C., B.S.J., M.B.P.) Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL. (B.S.J., M.B.P.) Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL. (B.S.J., M.B.P.) University of Utah School of Medicine, Salt Lake City (J.M.C.). Division of Neurosurgery, Department of Surgery, University of Toronto, (...) Stroke
  Stroke, Ahead of Print. Stroke is a major cause of morbidity and mortality. Neurosurgical decompression is often considered for the treatment of malignant infarcts and intraparenchymal hemorrhages, but this treatment can be frought with ethical dilemmas. In this article, the authors outline the (...) (Stroke)

Hypertension https://www.ahajournals.org/

• 11:00
  SGLT2 Inhibition via Empagliflozin Improves Endothelial Function and Reduces Mitochondrial Oxidative Stress: Insights From Frail Hypertensive and Diabetic Patients - Pasquale Mone Fahimeh Varzideh Stanislovas S. Jankauskas Antonella Pansini Angela Lombardi Salvatore Frullone Gaetano Santulli Asl Avellino, Albert Einstein College of Medicine, New York, NY. (P.M., A.P., S.F.). Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, New York, NY. (P.M., F.V., S.S.J., A.L., G.S.) Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY. (G.S.) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Frailty is a multidimensional condition often diagnosed in older adults with hypertension and diabetes, and both these conditions are associated with endothelial dysfunction and oxidative stress. We investigated the role of the SGLT2 (sodium glucose (...) (Hypertension)

Kidney Int http://www.kidney-international.org/

• 00:00
  Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies. - Mathias Gorski, Humaira Rasheed, Alexander Teumer, Laurent F. Thomas, Sarah E. Graham, Gardar Sveinbjornsson, Thomas W. Winkler, Felix Günther, Klaus J. Stark, Jin-Fang Chai, Bamidele O. Tayo, Matthias Wuttke, Yong Li, Adrienne Tin, Tarunveer S. Ahluwalia, Johan Ärnlöv, Bjørn Olav Åsvold, Stephan J.L. Bakker, Bernhard Banas, Nisha Bansal, Mary L. Biggs, Ginevra Biino, Michael Böhnke, Eric Boerwinkle, Erwin P. Bottinger, Hermann Brenner, Ben Brumpton, Robert J. Carroll, Layal Chaker, John Chalmers, Miao-Li Chee, Miao-Ling Chee, Ching-Yu Cheng, Audrey Y. Chu, Marina Ciullo, Massimiliano Cocca, (...) Kidney Int
  Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since (...) (Kidney International (2022))

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Basophils stoke the fire - Monica Wang Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 15 June 2022; doi:10.1038/s41581-022-00597-6Basophils stoke the fire (Nature Reviews Nephrology, Published online: 2022-06-15; | doi:10.1038/s41581-022-00597-6)

Diabetologia http://link.springer.com/

• 00:00
  Impact of diabetes on COVID-19 prognosis beyond comorbidity burden: the CORONADO initiative Diabetologia
  Abstract Aims/hypothesis Diabetes has been recognised as a pejorative prognostic factor in coronavirus disease 2019 (COVID-19). Since diabetes is typically a disease of advanced age, it remains unclear whether diabetes remains a COVID-19 risk factor beyond advanced age and associated (...)

14 June

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

• 12:42
  Prediction of Prehospital Change of the Cardiac Rhythm From Nonshockable to Shockable in Out?of?Hospital Patients With Cardiac Arrest: A Post Hoc Analysis of a Nationwide, Multicenter, Prospective Registry - Ryo Emoto, Mitsuaki Nishikimi , Muhammad Shoaib , Kei Hayashida , Kazuki Nishida , Kazuya Kikutani , Shinichiro Ohshimo , Shigeyuki Matsui , Nobuaki Shime , and Taku Iwami 1 Department of Biostatistics Nagoya University Graduate School of Medicine Nagoya Japan 2 Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan 3 Department of Emergency and Critical Care Medicine Nagoya University Graduate School of Medicine Nagoya Japan 4 Laboratory for Critical Care Physiology The Feinstein Institutes for Medical (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundPredicting a spontaneous rhythm change from nonshockable to shockable before hospital arrival in patients with out?of?hospital cardiac arrest can help emergency medical services develop better strategies for (...) (Journal of the American Heart Association)
• 12:41
  Association of Statins for Primary Prevention of Cardiovascular Diseases With Hospitalization for COVID?19: A Nationwide Matched Population?Based Cohort Study - Kim Bouillon, Bérangère Baricault , Laura Semenzato , Jérémie Botton , Marion Bertrand , Jérôme Drouin , Rosemary Dray?Spira , Alain Weill , and Mahmoud Zureik 1EPI?PHARE Scientific Interest Group in Epidemiology of Health Products Saint?Denis France 2Faculty of Pharmacy Paris?Saclay University Châtenay?Malabry France 3Paris?Saclay University UVSQ CESP?Inserm, Anti?infective evasion and pharmacoepidemiology Montigny le Bretonneux France J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundThere is little evidence on the relationship between statin use and the risk of hospitalization attributable to COVID?19.Methods and ResultsThe French National Healthcare Data System database was used to (...) (Journal of the American Heart Association)
• 12:41
  Hypertension and Diabetes Status by Patterns of Stress in Older Adults From the US Health and Retirement Study: A Latent Class Analysis - Jessica R. Fernandez, Francisco A. Montiel Ishino , Faustine Williams , Natalie Slopen , and Allana T. Forde 1Division of Intramural Research National Institute on Minority Health and Health DisparitiesNational Institutes of Health Bethesda MD 2Department of Social and Behavioral Sciences Harvard University T. H. Chan School of Public Health Boston MA J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundHypertension and diabetes disproportionately affect older non?Hispanic Black and Hispanic adults in the United States. Chronic stress may partially explain these disparities. This study identified underlying (...) (Journal of the American Heart Association)
• 12:40
  Development and Validation of 3?Year Atrial Fibrillation Prediction Models Using Electronic Health Record With or Without Standardized Electrocardiogram Diagnosis and a Performance Comparison Among Models - Yunjin Yum, Seung Yong Shin , Hakje Yoo , Yong Hyun Kim , Eung Ju Kim , Gregory Y. H. Lip , and Hyung Joon Joo 1 Department of Biostatistics Korea University College of Medicine Seoul Republic of Korea 2 Cardiovascular and Arrhythmia Center Chung?Ang University Hospital Seoul Republic of Korea 3 Korea University Research Institute for Medical Bigdata Science Korea University Seoul Republic of Korea 4 Department of Internal Medicine Korea University Ansan Hospital Seoul Republic of Korea 5 Cardiovascular Center Korea University Guro Hospital Seoul Republic of Korea 6 Liverpool Center for (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundImproved prediction of atrial fibrillation (AF) may allow for earlier interventions for stroke prevention, as well as mortality and morbidity from other AF?related complications. We developed a clinically (...) (Journal of the American Heart Association)
• 12:38
  Histone Deacetylase 6 Inhibitor JS28 Prevents Pathological Gene Expression in Cardiac Myocytes - Vivien Ngo, Bernd K. Fleischmann , Manfred Jung , Lutz Hein , and Achim Lother 1 Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine University of Freiburg Germany 2 Institute of Physiology I, Life & Brain Center, Medical Faculty University of Bonn Germany 3 Institute of Pharmaceutical Sciences University of Freiburg Germany 4 BIOSS Centre for Biological Signaling Studies University of Freiburg Germany 5 Interdisciplinary Medical Intensive Care (IMIT), Medical Center – University of Freiburg, Faculty of Medicine University of Freiburg (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundEpigenetic modulators have been proposed as promising new drug targets to treat adverse remodeling in heart failure. Here, we evaluated the potential of 4 epigenetic drugs, including the recently developed (...) (Journal of the American Heart Association)
• 12:38
  Association of Race and Ethnicity on the Management of Acute Non?ST?Segment Elevation Myocardial Infarction - Tarryn Tertulien, Stephen T. Broughton , Gretchen Swabe , Utibe R. Essien , and Jared W. Magnani 1 Department of Medicine University of Pittsburgh Medical Center Pittsburgh Pennsylvania 2 Division of Cardiology UPMC Heart and Vascular Institute, University of Pittsburgh Pittsburgh Pennsylvania 3 Center for Health Equity Research and Promotion VA Pittsburgh Healthcare System Pittsburgh Pennsylvania J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundPrior studies have reported disparities by race in the management of acute myocardial infarction (MI), with many studies having limited covariates or now dated. We examined racial and ethnic differences in (...) (Journal of the American Heart Association)
• 12:38
  Interaction Between Race, Ethnicity, Severe Mental Illness, and Cardiovascular Disease - Kevin O'Gallagher, James TH. Teo , Ajay M. Shah , and Fiona Gaughran 1 British Heart Foundation Centre of Research Excellence King’s College London London United Kingdom 2 King’s College Hospital NHS Foundation Trust London United Kingdom 3 Institute of Psychiatry, Psychology and Neuroscience King’s College London London United Kingdom 4 South London and Maudsley NHS Foundation Trust London United Kingdom J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. Severe mental illnesses, such as schizophrenia or bipolar disorder, affect ?1% of the population who, as a group, experience significant disadvantage in terms of physical health and reduced life expectancy. In this (...) (Journal of the American Heart Association)
• 12:37
  Prognostic Value of Exercise Capacity in Kidney Transplant Candidates - Sean Tan, Yi Wen Thang , William R. Mulley , Kevan R. Polkinghorne , Satish Ramkumar , Kevin Cheng , Jasmine Chan , John Galligan , Mark Nolan , Adam J. Brown , Stuart Moir , James D. Cameron , Stephen J. Nicholls , Philip M. Mottram , and Nitesh Nerlekar 1 Monash Cardiovascular Research Centre, Victorian Heart Institute Monash University Melbourne Victoria Australia 2 Monash Heart Monash Health Melbourne Victoria Australia 3 Department of Nephrology Monash Health Melbourne Victoria Australia 4 Department of Medicine Monash University Melbourne Victoria Australia 5 Baker Heart and (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundExercise stress testing for cardiovascular assessment in kidney transplant candidates has been shown to be a feasible alternative to pharmacologic methods. Exercise stress testing allows the additional (...) (Journal of the American Heart Association)
• 12:37
  Active RhoA Exerts an Inhibitory Effect on the Homeostasis and Angiogenic Capacity of Human Endothelial Cells - Michael Hauke, Robert Eckenstaler , Anne Ripperger , Anna Ender , Heike Braun , and Ralf A. Benndorf 1Department of Clinical Pharmacy and Pharmacotherapy Institute of PharmacyMartin?Luther?University Halle?Wittenberg Halle (Saale) Germany J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundThe small GTPase RhoA (Ras homolog gene family, member A) regulates a variety of cellular processes, including cell motility, proliferation, survival, and permeability. In addition, there are reports (...) (Journal of the American Heart Association)
• 12:37
  Effects of Clinical Trial or Research Program Participation Status on In?Hospital Mortality After Transcatheter Aortic Valve Implantation - Tadao Aikawa, Toshiki Kuno , Jef Van den Eynde , Alexandros Briasoulis , and Aaqib H. Malik 1 Department of Cardiology Hokkaido Cardiovascular Hospital Sapporo Japan 2 Department of Radiology Jichi Medical University Saitama Medical Center Saitama Japan 3 Division of Cardiology, Montefiore Medical Center Albert Einstein College of Medicine New York NY 4 Helen B. Taussig Heart Center The Johns Hopkins Hospital and School of Medicine Baltimore MD 5 Department of Cardiovascular Sciences KU Leuven Leuven Belgium 6 Section of Heart Failure and Transplantation, Division of Cardiovascular (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. (Journal of the American Heart Association)
• 12:37
  Moderate? and High?Intensity Exercise Improves Lipoprotein Profile and Cholesterol Efflux Capacity in Healthy Young Men - Kelly M. Stanton, Vivian Kienzle , Donna Lee M. Dinnes , Irina Kotchetkov , Wendy Jessup , Leonard Kritharides , David S. Celermajer , and Kerry?Anne Rye 1Heart Research Institute Sydney New South Wales Australia 2The University of Sydney New South Wales Australia 3Royal Brisbane and Women’s Hospital Herston Queensland Australia 4The ANZAC Research Institute Concord New South Wales Australia 5Royal Prince Alfred Hospital Sydney New South Wales Australia 6The University of New South Wales Sydney New South Wales (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundExercise is associated with a reduced risk of cardiovascular disease. Increased high?density lipoprotein cholesterol (HDL?C) levels are thought to contribute to these benefits, but much of the research in (...) (Journal of the American Heart Association)
• 12:36
  Integrating a Polygenic Risk Score for Coronary Artery Disease as a Risk?Enhancing Factor in the Pooled Cohort Equation: A Cost?Effectiveness Analysis Study - Deo Mujwara, Geoffrey Henno , Stephen T. Vernon , Siyang Peng , Paolo Di Domenico , Brock Schroeder , George B. Busby , Gemma A Figtree , and Giordano Bottà 1Allelica, Inc Wilmington DE 2 Illumina, Inc San Diego CA 3Kolling InstituteRoyal North Shore Hospital Sydney NSW Australia 4Charles Perkins CentreUniversity of Sydney NSW Australia 5Department of Cardiology Royal North Shore Hospital Sydney NSW Australia J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundCardiovascular diseases are the leading cause of death in the United States, yet a significant proportion of adults at high risk remain undetected by standard screening practices. Polygenic risk score for (...) (Journal of the American Heart Association)
• 12:36
  Sex?Specific Differences in Clinical Outcomes After Percutaneous Coronary Intervention: Insights from the TAILOR?PCI Trial - Mina Madan, J. Dawn Abbott , Ryan Lennon , Derek Y. F. So , Andrea M. MacDougall , Mary Ann McLaughlin , Vishakantha Murthy , Jacqueline Saw , Charanjit Rihal , Michael E. Farkouh , Naveen L. Pereira , Shaun G. Goodman 1Schulich Heart CentreSunnybrook Health Sciences CentreUniversity of Toronto Toronto Ontario Canada 2Division of Cardiology Lifespan Cardiovascular Institute Warren Alpert Medical School of Brown University Providence RI 3Department of Quantitative Health Sciences Mayo Clinic Rochester MN 4University of Ottawa Heart Institute Ottawa Ontario Canada 5Thunder Bay Regional (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundTAILOR?PCI (Tailored Antiplatelet Initiation to Lessen Outcomes due to decreased Clopidogrel Response After Percutaneous Coronary Intervention) studied genotype?guided selection of antiplatelet therapy after (...) (Journal of the American Heart Association)
• 12:35
  Sex?Based Differences in Outcomes Following Peripheral Artery Revascularization: Insights From VOYAGER PAD - Connie N. Hess, Iris Baumgartner , Sonia S. Anand , Mark R. Nehler , Manesh R. Patel , E. Sebastian Debus , Michael Szarek , Warren Capell , Eva Muehlhofer , Scott D. Berkowitz , Lloyd P. Haskell , Rupert M. Bauersachs , Marc P. Bonaca , and Judith Hsia 1 Division of Cardiology, Department of Medicine University of Colorado School of Medicine Aurora CO 2 CPC Clinical Research Aurora CO 3 Division of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital University of Bern Switzerland 4 Population Health Research Institute, Hamilton Health Sciences McMaster (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundDespite high female prevalence of peripheral artery disease (PAD), little is known about sex?based outcomes after lower extremity revascularization (LER) for symptomatic PAD. The effects of rivaroxaban (...) (Journal of the American Heart Association)
• 12:35
  Characterization of “ICU?30”: A Binary Composite Outcome for Neonates With Critical Congenital Heart Disease - Monique M. Gardner, Garrett Keim , Jill Hsia , Anh D. Mai , J. William Gaynor , Andrew C. Glatz , and Nadir Yehya 1Division of Cardiac Critical Care Department of Anesthesiology and Critical Care The Children’s Hospital of PhiladelphiaPerelman School of Medicine at the University of Pennsylvania Philadelphia PA 2Division of Critical Care Department of Anesthesiology and Critical Care The Children’s Hospital of PhiladelphiaPerelman School of Medicine at the University of Pennsylvania Philadelphia PA 3Division of Cardiology Department of Pediatrics The Children’s Hospital of Philadelphia (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundNeonates with heart disease requiring cardiopulmonary bypass surgery are at high risk for mortality and morbidity. As it is rare, short?term mortality is difficult to use as a primary outcome for clinical (...) (Journal of the American Heart Association)
• 12:34
  Aortic Dimensions Are Larger in Patients With Fibromuscular Dysplasia - Arielle M. Schwartz, Esther Kim , Patrick Gleason , Xiaona Li , Yi?An Ko , and Bryan J Wells 1 Willis Hurst Internal Medicine Residency Program Emory University Atlanta GA 2 Division of Cardiovascular Medicine, Department of Medicine Vanderbilt University Medical Center Nashville NC 3 Division of Cardiology, Department of Medicine Emory University School of Medicine Atlanta GA 4 Department of Biostatistics and Bioinformatics, Rollins School of Public Health Emory University Atlanta (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundFibromuscular dysplasia (FMD) is a disease of unknown etiology that causes stenosis, aneurysmal dilatation, and dissection of vascular beds. Known to affect medium?sized arteries, FMD is not typically (...) (Journal of the American Heart Association)
• 12:34
  Protective Effects of MicroRNA?200b?3p Encapsulated by Mesenchymal Stem Cells–Secreted Extracellular Vesicles in Myocardial Infarction Via Regulating BCL2L11 - Jun Wan, Shaoyan Lin , Zhuo Yu , Zhengkun Song , Xuefeng Lin , Rongning Xu , and Songlin Du 1Department of Cardiovascular Surgery Nanfang Hospital Southern Medical University Guangzhou Guangdong China J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundExtracellular vesicles (EVs) are a popular treatment candidate for myocardial injury. This work investigated the effects of mesenchymal stem cells (MSCs)–secreted EVs–derived miR?200b?3p on cardiomyocyte (...) (Journal of the American Heart Association)
• 12:34
  Systematic Review of Cerebral Phenotypes Associated With Monogenic Cerebral Small?Vessel Disease - Ed Whittaker, Sophie Thrippleton , Liza Y. W. Chong , Victoria G. Collins , Amy C. Ferguson , David E. Henshall , Emily Lancastle , Tim Wilkinson , Blair Wilson , Kirsty Wilson , Cathie Sudlow , Joanna Wardlaw , and Kristiina Rannikmäe 1Medical School University of Edinburgh Edinburgh United Kingdom 2Centre for Medical Informatics Usher Institute University of Edinburgh Edinburgh United Kingdom 3Centre for Clinical Brain Sciences University of Edinburgh Edinburgh United Kingdom 4NHS Greater Glasgow and Clyde Glasgow United Kingdom 5NHS Lothian Edinburgh United Kingdom 6BHF Data Science (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundCerebral small?vessel disease (cSVD) is an important cause of stroke and vascular dementia. Most cases are multifactorial, but an emerging minority have a monogenic cause. WhileNOTCH3is the best?known gene, (...) (Journal of the American Heart Association)
• 12:34
  Relative Contribution of Blood Pressure in Childhood, Young? and Mid?Adulthood to Large Artery Stiffness in Mid?Adulthood - Yaxing Meng, Marie?Jeanne Buscot , Markus Juonala , Feitong Wu , Matthew K. Armstrong , Brooklyn J. Fraser , Katja Pahkala , Nina Hutri?Kähönen , Mika Kähönen , Tomi Laitinen , Jorma S. A. Viikari , Olli T. Raitakari , Costan G. Magnussen , and James E. Sharman 1Menzies Institute for Medical ResearchUniversity of Tasmania Hobart Australia 2Department of Medicine University of Turku Turku Finland 3Division of Medicine Turku University Hospital Turku Finland 4Research Centre of Applied and Preventive Cardiovascular Medicine University of Turku Turku Finland 5Centre for Population Health (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundBlood pressure associates with arterial stiffness, but the contribution of blood pressure at different life stages is unclear. We examined the relative contribution of childhood, young? and mid?adulthood (...) (Journal of the American Heart Association)
• 12:33
  Corin Missense Variants, Blood Pressure, and Hypertension in 11 322 Black Individuals: Insights From REGARDS and the Jackson Heart Study - Vibhu Parcha, Marguerite R. Irvin , Leslie A. Lange , Nicole D. Armstrong , Akhil Pampana , Mariah Meyer , Suzanne E. Judd , Garima Arora , and Pankaj Arora 1Division of Cardiovascular Disease University of Alabama at Birmingham Birmingham AL 2Department of Epidemiology University of Alabama at Birmingham Birmingham AL 3Division of Biomedical Informatics and Personalized Medicine Department of Medicine University of Colorado School of Medicine Aurora CO 4Department of Epidemiology University of Colorado School of Public Health Aurora CO 5Department of Biostatistics University of Alabama (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundCorin enzyme contributes to the processing of inactive natriuretic peptides to bioactive hormones. In Black individuals, Corin gene variants (rs111253292 [Q568P] and rs75770792 [T555I]) have been previously (...) (Journal of the American Heart Association)
• 12:33
  Transcatheter Aortic Valve Implantation With and Without Resheathing and Repositioning: A Systematic Review and Meta?analysis - Francesco Moroni, Lorenzo Azzalini , Lars Sondergaard , Guilherme F. Attizzani , Santiago García , Hani Jneid , Mamas A. Mamas , and Rodrigo Bagur 1Division of Cardiology Pauley Heart CenterVirginia Commonwealth University Richmond VA 2Division of Cardiology Department of Medicine University of Washington Seattle WA 3The Heart Centre, RigshospitaletCopenhagen University Hospital Copenhagen Denmark 4Harrington Heart and Vascular InstituteUniversity Hospitals Cleveland Medical Center Cleveland OH 5The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital Cincinnati OH (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundThere is a concern that resheathing/repositioning of transcatheter heart valves during transcatheter aortic valve implantation (TAVI) may lead to an increased risk of periprocedural complications. We aimed (...) (Journal of the American Heart Association)
• 12:33
  Altered Cerebral Microstructure in Adults With Atrial Septal Defect and Ventricular Septal Defect Repaired in Childhood - Benjamin Asschenfeldt, Lars Evald , Camilla Salvig , Johan Heiberg , Leif Østergaard , Simon Fristed Eskildsen , and Vibeke Elisabeth Hjortdal 1Department of Cardiothoracic & Vascular Surgery Aarhus University Hospital Denmark 2Center of Functionally Integrative Neuroscience Aarhus University Denmark 3Department of Clinical Medicine Aarhus University Denmark 4Hammel Neurorehabilitation Centre and University Research Clinic Denmark 5Neuroradiology Research Unit, Department of Radiology Aarhus University Hospital Denmark 6Department of Cardiothoracic Surgery, Rigshospitalet and Institute of (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundDelayed brain development, brain injury, and neurodevelopmental disabilities are commonly observed in infants operated for complex congenital heart defect. Our previous findings of poorer neurodevelopmental (...) (Journal of the American Heart Association)
• 12:33
  Low?Density Lipoprotein Cholesterol Attributable Cardiovascular Disease Risk Is Sex Specific - Arjen J. Cupido, Folkert W. Asselbergs , A. Floriaan Schmidt , and G. Kees Hovingh 1Department of Vascular Medicine Amsterdam University Medical Centerslocation AMCUniversity of Amsterdam Netherlands 2Department of Cardiology Division of Heart & Lungs University Medical Center UtrechtUtrecht University Utrecht the Netherlands 3Division of Cardiology Department of Medicine University of California, Los Angeles Los Angeles CA 4Faculty of Population Health Sciences Institute of Cardiovascular ScienceUniversity College London London United Kingdom 5Health Data Research UK and Institute of (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundEpidemiological studies show that women are generally at lower risk for cardiovascular disease than men. Here, we investigated the sex?specific differential effect of genetically increased low?density (...) (Journal of the American Heart Association)
• 12:32
  Evaluation of a Population?Wide Mobile Health Physical Activity Program in 696 907 Adults in Singapore - Jiali Yao, Nicole Lim , Jeremy Tan , Andre Matthias Müller , Rob Martinus van Dam , Cynthia Chen , Chuen Seng Tan , and Falk Müller?Riemenschneider 1Saw Swee Hock School of Public Health National University of Singapore Singapore 2Policy, Research and Surveillance Division Health Promotion Board Singapore 3Berlin Institute of HealthCharite University Medical Centre Berlin Germany J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundEvidence of scaled?up physical activity interventions is scarce. This study evaluates the uptake, engagement, and effectiveness of one such intervention program.Methods and ResultsThe program was open to (...) (Journal of the American Heart Association)
• 12:32
  Radiofrequency Catheter Ablation for Pediatric Atrioventricular Nodal Reentrant Tachycardia: Impact of Age on Procedural Methods and Durable Success - Edward T. O’Leary, Jamie Harris , Kimberlee Gauvreau , Courtney Gentry , Audrey Dionne , Dominic J. Abrams , Mark E. Alexander , Vassilios J. Bezzerides , Elizabeth S. DeWitt , John K. Triedman , Edward P. Walsh , and Douglas Y. Mah 1Department of Cardiology Boston Children’s Hospital Boston MA 2Harvard Medical School Boston MA J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundCatheter?based slow?pathway modification (SPM) is the treatment of choice for symptomatic atrioventricular nodal reentrant tachycardia (AVNRT). We sought to investigate the interactions between patient age (...) (Journal of the American Heart Association)
• 12:32
  Association of Familial History of Diabetes, Hypertension, Dyslipidemia, Stroke, or Myocardial Infarction With Risk of Kawasaki Disease - Ji Hee Kwak, Eun Kyo Ha , Ju Hee Kim , Hye Ryung Cha , Seung Won Lee , and Man Yong Han 1Department of Pediatrics Kangbuk Samsung HospitalSungkyunkwan University School of Medicine Seoul Korea 2Department of Pediatrics Kangnam Sacred Heart HospitalHallym University College of Medicine Seoul Korea 3Department of Pediatrics Kangdong Sacred Heart HospitalHallym University College of Medicine Seoul Korea 4Department of Data Science Sejong University College of Software Convergence Seoul Korea 5Department of Precision Medicine Sungkyunkwan University School of Medicine Suwon Korea 6Department (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundThere are few studies on the association with Kawasaki disease in children and the family’s history of cardiovascular disease (CVD). The aim of this study was to identify the association of increased risks (...) (Journal of the American Heart Association)
• 12:32
  Correlation Between Cardiac Images, Biomarkers, and Amyloid Load in Wild?Type Transthyretin Amyloid Cardiomyopathy - Mami Morioka, Seiji Takashio , Naoya Nakashima , Masato Nishi , Akira Fujiyama , Kyoko Hirakawa , Shinsuke Hanatani , Hiroki Usuku , Eiichiro Yamamoto , Masafumi Kidoh , Seitaro Oda , Kenichi Matsushita , Mitsuharu Ueda , and Kenichi Tsujita 1Departments of Cardiovascular Medicine Graduate School of Medical Sciences Kumamoto University Kumamoto Japan 2Departments of Diagnostic Radiology Graduate School of Medical Sciences Kumamoto University Kumamoto Japan 3Departments of Neurology Graduate School of Medical Sciences Kumamoto University Kumamoto (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundSeveral imaging parameters and biomarkers provide diagnostic and prognostic information for wild?type transthyretin amyloid cardiomyopathy. However, the relevance of these parameters and their association (...) (Journal of the American Heart Association)

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

• 16:28
  Association between plasma Vitamin B5 levels and all?cause mortality: A nested case?control study - Yuan Hong, Ziyi Zhou, Nan Zhang, Qiangqiang He, Zhangyou Guo, Lishun Liu, Yun Song, Ping Chen, Yaping Wei, Qiuyue Xu, Ya Li, Binyan Wang, Xianhui Qin, Xiping Xu, Yong Duan J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)
• 10:44
  Arterial stiffness and contralateral differences in blood pressure: The Atherosclerosis Risk in Communities (ARIC) study - Daniela Charry, Natalia Gouskova, Michelle L. Meyer, Kimberley Ring, Vijay Nambi, Gerardo Heiss, Hirofumi Tanaka J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)

Stroke https://www.ahajournals.org/

• 11:00
  TAGE Score for Symptomatic Intracranial Hemorrhage Prediction After Successful Endovascular Treatment in Acute Ischemic Stroke - Paul Janvier Basile Kerleroux Guillaume Turc Marco Pasi Wassim Farhat Nicolas Bricout Joseph Benzakoun Laurence Legrand Frédéric Clarençon Serge Bracard Catherine Oppenheim Grégoire Boulouis Hilde Henon Olivier Naggara Wagih Ben Hassen Department of Neuroradiology, Université de Paris, INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, GHU-Paris Psychiatrie et Neurosciences, Hôpital Sainte Anne, France. (P.J., B.K., J.B., L.L., C.O., O.N., W.B.H.) Neurolog, Université de Paris, INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, GHU-Paris Psychiatrie et Neurosciences, (...) Stroke
  Stroke, Ahead of Print. Background:Determine if early venous filling (EVF) after complete successful recanalization with mechanical thrombectomy in acute ischemic stroke is an independent predictor of symptomatic intracranial hemorrhage (sICH) and integrate EVF into a risk score for sICH (...) (Stroke)

Circulation http://ahajournals.org/

• 09:00
  Correction to: Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity Circulation
  Circulation, Ahead of Print. (Circulation)

J Human Hypertens http://www.nature.com/jhh/

• 00:00
  A comparison of paediatric hypertension clinical practice guidelines and their ability to predict adult hypertension in an African birth cohort - A. Craig, L. J. Ware, W. Mapanga, S. A. Norris J Human Hypertens
  Journal of Human Hypertension, Published online: 14 June 2022; doi:10.1038/s41371-022-00709-6A comparison of paediatric hypertension clinical practice guidelines and their ability to predict adult hypertension in an African birth (...) (Journal of Human Hypertension, Published online: 2022-06-14; | doi:10.1038/s41371-022-00709-6)

Eur Heart J https://academic.oup.com/site_5375/

• 02:00
  The complex link among heart failure, atrial fibrillation, and lung diseases, and an update on cardiac transplantation - Crea F. Eur Heart J

13 June

Stroke https://www.ahajournals.org/

• 11:00
  Detecting Silent Acute Microinfarcts in Cerebral Small Vessel Disease Using Submillimeter Diffusion-Weighted Magnetic Resonance Imaging: Preliminary Results - Karen Misquitta Marietou Daou John Conklin Congyu Liao Kawin Setsompop Julien Poublanc Zahra Shirzadi Bradley J. MacIntosh George Tomlinson Melanie Cohn Richard I. Aviv Frank L. Silver Daniel M. Mandell University Health Network (K.M., M.D., J.P., G.T., M.C., F.S., D.M.M.), University of Toronto, Canada. Department of Medical Biophysics (Z.S., B.J.M.), University of Toronto, Canada. Massachusetts General Hospital, Boston (J.C.). Stanford University, Stanford, CA (C.L., K.S.). University of Ottawa, Canada (...) Stroke
  Stroke, Volume 53, Issue 7, Page e251-e252, July 1, 2022. (Stroke)

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

• 13:10
  Prediction of atrial fibrillation in patients with hypertension: A comprehensive comparison of office and ambulatory blood pressure measurements - Pin?Hsiang Huang, Chin?Chou Huang, Shing?Jong Lin, Jaw?Wen Chen J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)
• 12:39
  The impact of continuous positive airway pressure on cardiac mechanics: Findings from a meta?analysis of echocardiographic studies - Marijana Tadic, Elisa Gherbesi, Andrea Faggiano, Carla Sala, Stefano Carugo, Cesare Cuspidi J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- META?ANALYSIS (Wiley: The Journal of Clinical Hypertension: Table of Contents)

Stroke https://www.ahajournals.org/

• 11:00
  Toward a Better Understanding of Sex- and Gender-Related Differences in Endovascular Stroke Treatment: A Scientific Statement From the American Heart Association/American Stroke Association - Johanna M. Ospel Joanna D. Schaafsma Thabele M. Leslie-Mazwi Sepideh Amin-Hanjani Negar Asdaghi Gillian L. Gordon-Perue Philippe Couillard Niloufar N. Hadidi Cheryl Bushnell Louise D. McCullough Mayank Goyal Stroke
  Stroke, Ahead of Print. There are many unknowns when it comes to the role of sex in the pathophysiology and management of acute ischemic stroke. This is particularly true for endovascular treatment (EVT). It has only recently been established as standard of care; therefore, data are even more (...) (Stroke)
• 11:00
  Revacept, an Inhibitor of Platelet Adhesion in Symptomatic Carotid Stenosis: A Multicenter Randomized Phase II Trial - Timo Uphaus Toby Richards Christian Weimar Hermann Neugebauer Sven Poli Karin Weissenborn Christopher Imray Dominik Michalski Hisham Rashid Ian Loftus Christian Rummey Martin Ritter Till-Karsten Hauser Götz Münch Klaus Gröschel Holger Poppert Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Germany (T.U., K.G.). Department of Vascular Surgery, University of Western Australia, Fiona Stanley Hospital, Perth, Australia (T.R.). Institute for Medical Informatics, Biometry and Epidemiology, University Hospital, University Duisburg-Essen, Essen, Germany (...) Stroke
  Stroke, Ahead of Print. BACKGROUND:Patients with symptomatic internal carotid artery (ICA) stenosis are at high risk of recurrent ischemic stroke and require early interventional treatment and antiplatelet therapy. Increased bleeding rates might counterbalance the periprocedural efficacy of (...) (Stroke)

Hypertension https://www.ahajournals.org/

• 11:00
  Per- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women's Health Across the Nation - Ning Ding Carrie A. Karvonen-Gutierrez Bhramar Mukherjee Antonia M. Calafat Siobán D. Harlow Sung Kyun Park Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor. (N.D., C.A.K.-G., S.D.H., S.K.P.) Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor. (B.M.) Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor. (S.K.P.) Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA (...) Hypertension
  Hypertension, Ahead of Print. Background:Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are ubiquitous synthetic chemicals that may disrupt blood pressure controls; however, human evidence to support this hypothesis is scant. We examined the association between serum concentrations of (...) (Hypertension)

Circulation http://ahajournals.org/

• 11:00
  Differences in Comorbidities Explain Black–White Disparities in Outcomes After Femoropopliteal Endovascular Intervention - Anna K. Krawisz Sahana Natesan Rishi K. Wadhera Siyan Chen Yang Song Robert W. Yeh Michael R. Jaff Jay Giri Howard Julien Eric A. Secemsky Department of Medicine, Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Beth Israel Deaconess Medical Center, Boston, MA. (A.K.K., S.N., R.K.W., S.C., Y.S., R.W.Y., E.A.S.) Department of Medicine, Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA. (A.K.K., R.K.W., R.W.Y., E.A.S.) Harvard Medical School, Boston, MA (A.K.K., R.K.W., R.W.Y., M.R.J., E.A.S.). Penn Cardiovascular Outcomes, Quality, & (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Black adults have a higher incidence of peripheral artery disease and limb amputations than White adults in the United States. Given that peripheral endovascular intervention (PVI) is now the primary revascularization strategy for peripheral artery (...) (Circulation)
• 08:00
  Premature Complexes and Blocked P Wave - Ethan Morgan John Anderson Amit Noheria Department of Internal Medicine (E.M.), University of Kansas Medical Center, Kansas City. Department of Cardiovascular Medicine (J.A., A.N.), University of Kansas Medical Center, Kansas City. Circulation
  Circulation, Volume 145, Issue 24, Page 1803-1805, June 14, 2022. (Circulation)
• 08:00
  Higher Incidence of Chromosomal Aberrations in Operators Performing a Large Volume of Endovascular Procedures - Mohamed A. Abdelhalim Ashish Patel Jayne Moquet Prakash Saha Alberto Smith Christophe Badie Rhona Anderson Elizabeth Ainsbury Bijan Modarai Academic Department of Vascular Surgery, School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, British Heart Foundation Centre of Research Excellence and Guy’s and St. Thomas’ National Health Service Foundation Trust Biomedical Research Centre, United Kingdom (M.A.A., A.P., P.S., A.S., B.M.). United Kingdom Health Security Agency Centre for Radiation, Chemical and Environmental Threats and Hazards, Chilton, United Kingdom (...) Circulation
  Circulation, Volume 145, Issue 24, Page 1808-1810, June 14, 2022. (Circulation)
• 08:00
  What Does the American Heart Association Do (and How Can You Help)? - Donald M. Lloyd-Jones Departments of Preventive Medicine, Medicine, and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL. Circulation
  Circulation, Volume 145, Issue 24, Page e1073-e1076, June 14, 2022. (Circulation)
• 08:00
  From the Literature - Tracy Hampton Circulation
  Circulation, Volume 145, Issue 24, Page 1806-1807, June 14, 2022. (Circulation)
• 08:00
  Environmental Triggers of Acute Coronary Syndromes - Nicholas L. Mills C. Arden Pope BHF Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (N.L.M.). Usher Institute, University of Edinburgh, United Kingdom (N.L.M.). Brigham Young University, Provo, UT (C.A.P.). Circulation
  Circulation, Volume 145, Issue 24, Page 1761-1763, June 14, 2022. (Circulation)
• 08:00
  Expanding the Therapeutic World of Tryptophan Metabolism - Gregory A. Wyant Javid Moslehi Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA (G.A.W.). Howard Hughes Medical Institute, Chevy Chase, MD (G.A.W.). Section of Cardio-Oncology and Immunology, Division of Cardiology and the Cardiovascular Research Institute, University of California San Francisco (J.M.). Circulation
  Circulation, Volume 145, Issue 24, Page 1799-1802, June 14, 2022. (Circulation)
• 08:00
  At the Crossroad Between Skeletal and Cardiac Muscle Cells - Christopher R. deFilippi Abdulla A. Damluji From the Inova Heart and Vascular Institute, Falls Church, VA (C.R.d.F., A.A.D.). Johns Hopkins University School of Medicine, Baltimore, MD (A.A.D.). Circulation
  Circulation, Volume 145, Issue 24, Page 1780-1783, June 14, 2022. (Circulation)

10 June

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

• 18:13
  Osteocalcin association with vascular function in chronic kidney disease - Xinru Guo, Yisha Li, Yena Zhou, Chun Zhang, Shuang Liang, Ying Zheng, Xiangmei Chen, Guangyan Cai J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)

Stroke https://www.ahajournals.org/

• 11:00
  Longitudinal Study Reveals Long-Term Proinflammatory Proteomic Signature After Ischemic Stroke Across Subtypes - Tara M. Stanne Annelie Angerfors Björn Andersson Cecilia Brännmark Lukas Holmegaard Christina Jern Institute of Biomedicine, Department of Laboratory Medicine, the Sahlgrenska Academy, University of Gothenburg, Sweden (T.M.S., A.A., C.B., C.J.). Bioinformatics Core Facility, University of Gothenburg, Sweden (B.A.). Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, the Sahlgrenska Academy, University of Gothenburg, Sweden (L.H.). Department of Neurology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden. (L.H.) Department of Clinical (...) Stroke
  Stroke, Ahead of Print. Background:Inflammation contributes both to the pathogenesis of stroke and the response to brain injury. We aimed to identify proteins reflecting the acute-phase response and proteins more likely to reflect proinflammatory processes present before stroke by broadly (...) (Stroke)
• 11:00
  Thrombolysis for Acute Ischemic Stroke in Patients With Premorbid Disability: A Meta-Analysis - Benjamin Beland Fouzi Bala Aravind Ganesh Department of Clinical Neurosciences, University of Calgary, Alberta, Canada. Stroke
  Stroke, Ahead of Print. BACKGROUND:Randomized controlled trials for the use of alteplase in acute ischemic stroke have excluded or had little representation of patients with prestroke disability, and the benefit of alteplase in this population remains uncertain. We performed a systematic review (...) (Stroke)

Hypertension https://www.ahajournals.org/

• 11:00
  Management and Outcomes of Primary Aldosteronism in Pregnancy: A Systematic Review - Viola Sanga Giacomo Rossitto Teresa Maria Seccia Gian Paolo Rossi Hypertension and Emergency Unit, Department of Medicine - DIMED, University of Padua, Italy. (V.S., T.M.S., G.P.R.) PhD Arterial Hypertension and Vascular Biology, Department of Medicine - DIMED, University of Padua, Italy. (V.S.) Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (G.R.). Hypertension
  Hypertension, Ahead of Print. Primary aldosteronism (PA) in pregnancy (PAP) can be a serious condition and is challenging to diagnose. This study was conceived to help in the diagnosis of PAP and provide suggestions on management of PAP based on evidence retrieved using a Population, (...) (Hypertension)
• 11:00
  IsoLGs (Isolevuglandins) Drive Neutrophil Migration in Hypertension and Are Essential for the Formation of Neutrophil Extracellular Traps - Jaya Krishnan Néstor de la Visitación Elizabeth M. Hennen Venkataraman Amarnath David G. Harrison David M. Patrick Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center. (J.K., N.d.l.V., V.A., D.G.H., D.M.P.) Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center. (D.G.H., D.M.P.) Department of Biomedical Engineering, Vanderbilt University (E.M.H.). Department of Veterans Affairs, Nashville, TN (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:IsoLGs (isolevuglandins) are electrophilic products of lipid peroxidation formed in the presence of reactive oxygen species. IsoLGs contribute to hypertension by an unknown mechanism. Studies have shown that reactive oxygen species production drives the (...) (Hypertension)
• 11:00
  Effects of Ramipril on Biomarkers of Endothelial Dysfunction and Inflammation in Hypertensive Children on Maintenance Hemodialysis: the SEARCH Randomized Placebo-Controlled Trial - Areej Mohamed Ateya Ihab El Hakim Sara Mahmoud Shahin Radwa El Borolossy Reinhold Kreutz Nagwa Ali Sabri Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (A.M.A., S.M.S., R.E.B., N.A.S.). Charité – Universitätsmedizin Berlin, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany (A.M.A., R.K.). Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt (I.E.H.). Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Hypertension, endothelial dysfunction, and inflammation are associated with increased cardiovascular mortality in end-stage kidney disease. We evaluated the effects of ACE (angiotensin-converting enzyme) inhibition on biomarkers of endothelial (...) (Hypertension)

J Human Hypertens http://www.nature.com/jhh/

• 00:00
  The World Hypertension League Science of Salt: a regularly updated systematic review of salt and health outcomes studies (Sept 2019 to Dec 2020) - Nan Xin Wang, JoAnne Arcand, Norm R. C. Campbell, Claire Johnson, Daniela Malta, Kristina Petersen, Sarah Rae, Joseph Alvin Santos, Bridve Sivakumar, Sudhir Raj Thout, Rachael McLean J Human Hypertens
  Journal of Human Hypertension, Published online: 10 June 2022; doi:10.1038/s41371-022-00710-zThe World Hypertension League Science of Salt: a regularly updated systematic review of salt and health outcomes studies (Sept 2019 to Dec (...) (Journal of Human Hypertension, Published online: 2022-06-10; | doi:10.1038/s41371-022-00710-z)

Diabetologia http://link.springer.com/

• 00:00
  GLP-1 receptor nitration contributes to loss of brain pericyte function in a mouse model of diabetes Diabetologia
  Abstract Aims/hypothesis We have previously shown that diabetes causes pericyte dysfunction, leading to loss of vascular integrity and vascular cognitive impairment and dementia (VCID). Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs), used in managing type 2 diabetes mellitus, (...)

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

• 08:50
  Identifying and treating resistant hypertension in PRECISION: A randomized long?term clinical trial with aprocitentan - Parisa Danaietash, Pierre Verweij, Ji?Guang Wang, George Dresser, Ilkka Kantola, Mary Katherine Lawrence, Krzysztof Narkiewicz, Markus Schlaich, Marc Bellet, the PRECISION investigators J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)

9 June

Lancet Diab Endocrinol https://www.thelancet.com/journals/landia/home

• 00:30
  [Editorial] Prioritising COVID-19 over everything: the unintended harm - The Lancet Diabetes & Endocrinology Lancet Diab Endocrinol
  During the past 2 and a half years, countries worldwide saw disruptions in their health-care services as they redirected their efforts and resources to manage the COVID-19 pandemic. At the same time, many people with underlying conditions limited their interactions with others unless necessary, (...) (The Lancet Diabetes & Endocrinology 10, 7 (2022))

Circulation http://ahajournals.org/

• 03:56
  Left-Sided Degenerative Valvular Heart Disease in Type 1 and Type 2 Diabetes - Araz Rawshani Naveed Sattar Darren K. McGuire Oskar Wallström Ulf Smith Jan Borén Göran Bergström Elmir Omerovic Annika Rosengren Björn Eliasson Deepak L. Bhatt Aidin Rawshani Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sweden; Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, University of Gothenburg, Sweden Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, Glasgow, UK Department of Internal Medicine, University of Texas Southwestern (...) Circulation
  Circulation, Ahead of Print. Background: The role of diabetes in the development of valvular heart disease and particularly the relation with risk factor control, has not been extensively studied.Methods: We included 715,143 patients with diabetes registered in the Swedish National Diabetes (...) (Circulation)

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

• 17:31
  Issue Information J Clin Hypertens
  The Journal of Clinical Hypertension, Volume 24, Issue 6, Page 663-666, June 2022. -- ISSUE INFORMATION (Wiley: The Journal of Clinical Hypertension: Table of Contents)

Circulation http://ahajournals.org/

• 11:00
  Association of Neighborhood-Level Material Deprivation With Atrial Fibrillation Care in a Single-Payer Health Care System: A Population-Based Cohort Study - Husam Abdel-Qadir Leo E. Akioyamen Jiming Fang Andrea Pang Andrew C.T. Ha Cynthia A. Jackevicius David A. Alter Peter C. Austin Clare L. Atzema R. Sacha Bhatia Gillian L. Booth Sharon Johnston Irfan Dhalla Moira K. Kapral Harlan M. Krumholz Candace D. McNaughton Idan Roifman Karen Tu Jacob A. Udell Harindra C. Wijeysundera Dennis T. Ko Michael J. Schull Douglas S. Lee Women’s College Hospital, Toronto, Canada (H.A.-Q., J.A.U.). University Health Network, Toronto, Canada (H.A.-Q., A.C.T.H., C.A.J., D.A.A., R.S.B., M.K.K., K.T., J.A.U., D.S.L.). ICES (formerly known as the Institute for (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:There are limited data on the association of material deprivation with clinical care and outcomes after atrial fibrillation (AF) diagnosis in jurisdictions with universal health care.METHODS:This was a population-based cohort study of individuals ?66 years (...) (Circulation)

8 June

Stroke https://www.ahajournals.org/

• 11:00
  Role of Endothelial Cells and Platelets in COVID-Related Cerebrovascular Events - Nabil J. Alkayed Marilyn J. Cipolla Department of Anesthesiology and Perioperative Medicine and Knight Cardiovascular Institute, Portland, OR (N.J.A.). Department of Neurological Sciences, University of Vermont Larner College of Medicine, Burlington (M.J.C.). Stroke
  Stroke, Volume 53, Issue 7, Page 2389-2392, July 1, 2022. (Stroke)
• 11:00
  Cardiovascular Events After Intracerebral Hemorrhage - Linxin Li Santosh B. Murthy Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom (L.L.). Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, NY (S.B.M.). Stroke
  Stroke, Volume 53, Issue 7, Page 2131-2141, July 1, 2022. Cardiovascular events after primary intracerebral hemorrhage (ICH) have emerged as a leading cause of poor functional outcomes and mortality during the long-term recovery after an ICH. These events encompass arterial ischemic events such (...) (Stroke)

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

• 13:52
  Underdiagnosis and Undertreatment of Modifiable Cardiovascular Risk Factors Among Survivors of Childhood Cancer - Eric J. Chow, Yan Chen , Gregory T. Armstrong , Laura?Mae Baldwin , Casey R. Cai , Todd M. Gibson , Melissa M. Hudson , Aaron McDonald , Paul C. Nathan , Jeffrey E. Olgin , Karen L. Syrjala , Emily S. Tonorezos , Kevin C. Oeffinger , and Yutaka Yasui 1Public Health Sciences and Clinical Research Divisions Fred Hutchinson Cancer Research Center Seattle WA 2Department of Pediatrics Seattle Children’s HospitalUniversity of Washington Seattle WA 3University of Alberta Edmonton Alberta Canada 4Department of Epidemiology and Cancer Control St. Jude Children’s Research Hospital Memphis TN (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 12, June 21, 2022. BackgroundDetermine the prevalence and predictors associated with underdiagnosis and undertreatment of modifiable cardiovascular disease (CVD) risk factors (hypertension, dyslipidemia, glucose intolerance/diabetes) (...) (Journal of the American Heart Association)

Kidney Int http://www.kidney-international.org/

• 00:00
  Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications - Maciej Tomaszewski, Andrew P. Morris, Joanna M. Howson, Nora Franceschini, James Eales, Xiaoguang Xu, Sergey Dikalov, Tomasz J. Guzik, Benjamin Humphreys, Stephen Harrap, Fadi J. Charchar Kidney Int
  Hypertension is a major cardiovascular disease risk factor and contributor to premature death globally. Family-based investigations confirmed a significant heritable component of blood pressure (BP), whereas genome-wide association studies revealed >1000 common and rare genetic variants (...) (Kidney International (2022))

Hypertension https://www.ahajournals.org/

• 11:00
  Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na+/H+ Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway - Xiaoliang Jiang Yunpeng Liu Xin-Yang Zhang Xue Liu Xing Liu Xianxian Wu Pedro A. Jose Shun Duan Fu-Jian Xu Zhiwei Yang NHC Key Laboratory of Human Disease Comparative Medicine (The Institute of Laboratory Animal Sciences, CAMS&PUMC), National Human Diseases Animal Model Resource Center, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, P.R. China (X.J., Y.L., Xue Liu, Xing Liu, X.W., Z.Y.). Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education, Beijing Laboratory of (...) Hypertension
  Hypertension, Ahead of Print. Background:The present study directly tested the crucial role of intestinal gastrin/CCKBR (cholecystokinin B receptor) in the treatment of salt-sensitive hypertension.Methods:Adult intestine-specificCckbr-knockout mice (Cckbrfl/flvillin-Cre) and Dahl salt-sensitive (...) (Hypertension)
• 11:00
  Association Between the Gut Microbiome and Their Metabolites With Human Blood Pressure Variability - Evany Dinakis Michael Nakai Paul Gill Rosilene Ribeiro Stephanie Yiallourou Yusuke Sata Jane Muir Melinda Carrington Geoffrey A. Head David M. Kaye Francine Z. Marques Hypertension Research Laboratory, School of Biological Sciences, Monash University, Melbourne, Australia. (E.D., M.N.) Department of Gastroenterology, Monash University, Melbourne, Australia. (P.G., J.M.) Central Clinical School, Faculty of Medicine Nursing and Health Sciences, Monash University, Melbourne, Australia. (Y.S., D.M.K.) Department of Pharmacology, Faculty of Medicine Nursing and Health Sciences, Monash (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Blood pressure (BP) variability is an independent risk factor for cardiovascular events. Recent evidence supports a role for the gut microbiota in BP regulation. However, whether the gut microbiome is associated with BP variability is yet to be (...) (Hypertension)
• 08:00
  Correction to: Prospective Evaluation of International Prediction of Pregnancy Complications Collaborative Network Models for Prediction of Preeclampsia: Role of Serum sFlt-1 at 11–13 Weeks’ Gestation Hypertension
  Hypertension, Volume 79, Issue 7, Page e113-e113, July 1, 2022. (Hypertension)

Kidney Int http://www.kidney-international.org/

• 00:00
  The Case | A pregnant female with refractory hypocalcemia - Xin Yee Tan, Mary-Beth Roberts, Leila Z. Khan, John Stewart, Xiangling Wang Kidney Int
  A 25-year-old gravida 1 parity 0 female patient at 20 weeks of gestation was found to have asymptomatic hypocalcemia during her prenatal evaluation. Despite calcium and calcitriol supplementation for 4 months, her hypocalcemia persisted. The patient had no medical or surgical history, and there (...) (Kidney International (2022))

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

• 12:23
  Simple renal cyst as an independent risk factor for hypertension - Yaqing Zhou, Limei Jia, Baojin Lu, Long Bai, Wei Cui J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)
• 12:19
  Comparative efficacy of generic nifedipine versus brand?name amlodipine for hypertension management in Taiwan - Hao?Wei Lee, Chin?Chou Huang, Hsin?Bang Leu, Yenn?Jiang Lin J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)
• 07:40
  Risk factors for decline in Montreal Cognitive Assessment (MoCA) scores in patients with acute transient ischemic attack and minor stroke - Lijun Zuo, YanHong Dong, Xiaoling Liao, Yuesong Pan, Xianglong Xiang, Xia Meng, Hao Li, Xingquan Zhao, Yilong Wang, Jiong Shi, Yongjun Wang J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)

JAMA Cardiology https://jamanetwork.com/journals/jamacardiology

• 02:00
  A Child With Heart Failure and Bumpy Lesions on the Back - Arvind B, Ramakumar V, Ramakrishnan S. JAMA Cardiology
  This case report describes a diagnosis of acute rheumatic fever in a child presenting with fever, dyspnea, and multiple subcutaneous nodules.

Stroke https://www.ahajournals.org/

• 11:00
  Determinants of Symptomatic Intracranial Hemorrhage After Endovascular Stroke Treatment: A Retrospective Cohort Study - Wouter van der Steen Nadinda A.M. van der Ende Katinka R. van Kranendonk Vicky Chalos Robert J. van Oostenbrugge Wim H. van Zwam Yvo B.W.E.M. Roos Pieter J. van Doormaal Adriaan C.G.M. van Es Hester F. Lingsma Charles B.L.M. Majoie Aad van der Lugt Diederik W.J. Dippel Bob Roozenbeek Department of Neurology (W.v.d.S., N.A.M.v.d.E., V.C., D.W.J.D., B.R.), Erasmus MC University Medical Center, Rotterdam, the Netherlands. Department of Radiology and Nuclear Medicine (W.v.d.S., N.A.M.v.d.E., V.C., P.J.v.D., A.v.d.L., B.R.), Erasmus MC University Medical Center, Rotterdam, the Netherlands. (...) Stroke
  Stroke, Ahead of Print. Background:Symptomatic intracranial hemorrhage (sICH) is a serious complication after endovascular treatment for ischemic stroke. We aimed to identify determinants of its occurrence and location.Methods:We retrospectively analyzed data from the Dutch MR CLEAN trial (...) (Stroke)
• 11:00
  Intraarterial Nimodipine Versus Induced Hypertension for Delayed Cerebral Ischemia: A Modified Treatment Protocol - Miriam Weiss Walid Albanna Catharina Conzen-Dilger Nick Kastenholz Katharina Seyfried Hani Ridwan Martin Wiesmann Michael Veldeman Tobias Philip Schmidt Murad Megjhani Henna Schulze-Steinen Hans Clusmann Marinus Johannes Hermanus Aries Soojin Park Gerrit Alexander Schubert Department of Neurosurgery (M.W., W.A., C.C.-D., N.K., K.S., M.V., T.P.S., H.C., G.A.S.), RWTH Aachen University, Germany. Department of Diagnostic and Interventional Neuroradiology (H.R., M.W.), RWTH Aachen University, Germany. Department of Intensive Care Medicine and Perioperative Care (H.S.-S.), RWTH Aachen (...) Stroke
  Stroke, Ahead of Print. Background:Rescue treatment for delayed cerebral ischemia (DCI) after subarachnoid hemorrhage can include induced hypertension (iHTN) and, in refractory cases, endovascular approaches, of which selective, continuous intraarterial nimodipine (IAN) is one variant. The (...) (Stroke)
• 11:00
  Natural History of Asymptomatic Moderate Carotid Artery Stenosis in a Large Community-Based Cohort - Rebecca C. Gologorsky Elizabeth Lancaster Lue-Yen Tucker Mai N. Nguyen-Huynh Kara A. Rothenberg Andrew L. Avins Hui C. Kuang Robert W. Chang Department of Surgery, University of California, San Francisco, East Bay, Oakland (R.C.G., K.A.R.). Department of Surgery, University of California, San Francisco (E.L.). Division of Research, Kaiser Permanente Northern California, Oakland (L.-Y.T., M.N.N.-H., A.L.A., R.W.C.). Department of Surgery, The Permanente Medical Group, Inc, Walnut Creek, CA (M.N.N.-H.,). Departments of Medicine and Epidemiology and Biostatistics, University of California, (...) Stroke
  Stroke, Ahead of Print. Background:Moderate carotid artery stenosis is a poorly defined risk factor for ischemic stroke. As such, practice recommendations are lacking. In this study, we describe the long-term risk of stroke in patients with moderate asymptomatic stenosis in an integrated health (...) (Stroke)
• 11:00
  Treating Delayed Cerebral Ischemia: Should We Focus on Blood Pressure or Vasodilatation? - Ofer Sadan Feras Akbik Division of Neurocritical Care, Department of Neurology and Neurosurgery, Emory University School of Medicine, Atlanta, GA. Stroke
  Stroke, Ahead of Print. (Stroke)

Hypertension https://www.ahajournals.org/

• 11:00
  MANP (Mutant Atrial Natriuretic Peptide) Activation of the cGMP (3’,5’, Cyclic Guanosine Monophosphate) Inhibits Aldosterone via PDE2 (Phosphodiesterase 2) and Cytochrome p450 Family 11 Subfamily b Member 2 in H295R Cells and in Mice - Yang Chen Seethalakshmi R. Iyer Viacheslav O. Nikolaev Fabio Naro Manuela Pellegrini Silvia Cardarelli Xiao Ma Hon-Chi Lee John C. Burnett Cardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester MN. (Y.C., S.R.I., X.M., J.C.B.) Department of Cardiovascular Medicine, Mayo Clinic, Rochester MN. (H.-C.L.) Institute of Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia (Y.C.). Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Germany (V.O.N.). Department of Anatomical, Histological, (...) Hypertension
  Hypertension, Ahead of Print. BACKGROUND:Aldosterone is a critical pathological driver for cardiac and renal diseases. We recently discovered that MANP (mutant atrial natriuretic peptide), a novel ANP (atrial natriuretic peptide) analog, possessed more potent aldosterone inhibitory action than (...) (Hypertension)

7 June

Clin J Am Soc Nephrol https://cjasn.asnjournals.org/

• 19:00
  COVID-19 Vaccination for Patients Undergoing Long-Term Hemodialysis - Korst, U. K. H. Clin J Am Soc Nephrol
• 19:00
  Medicare Bundled Payment Policy and Anemia Care: Perspectives from a Patient with Kidney Disease - Thomas, C. Clin J Am Soc Nephrol
• 19:00
  Conflicts of Interest and the Trustworthiness of Clinical Practice Guidelines - Mathew, A., Clase, C. M. Clin J Am Soc Nephrol
• 19:00
  Safety of SGLT2 Inhibitors in CKD: Walking the Fine Line - Dobre, M. Clin J Am Soc Nephrol
• 19:00
  Fractional Excretion of Sodium (FENa): An Imperfect Tool for a Flawed Question - Seethapathy, H., Fenves, A. Z. Clin J Am Soc Nephrol
• 19:00
  Clinical Utility of COVID-19 Vaccination in Patients Undergoing Hemodialysis - Oliver, M. J., Blake, P. G. Clin J Am Soc Nephrol
• 19:00
  International Variation in Time on Peritoneal Dialysis: Time for a Closer Look? - Rivara, M. B. Clin J Am Soc Nephrol
• 19:00
  Diagnostic Performance of Fractional Excretion of Sodium for the Differential Diagnosis of Acute Kidney Injury: A Systematic Review and Meta-Analysis - Abdelhafez, M., Nayfeh, T., Atieh, A., AbuShamma, O., Babaa, B., Baniowda, M., Hrizat, A., Hasan, B., Hassett, L., Hamadah, A., Gharaibeh, K. Clin J Am Soc Nephrol
  Background and objectives AKI is classified as prerenal, intrinsic, and postrenal. Prerenal AKI and intrinsic AKI represent the most common causes for AKI in hospitalized patients. This study aimed to examine the accuracy of the fractional excretion of sodium for distinguishing intrinsic from (...)
• 19:00
  Apolipoprotein L1 High-Risk Genotypes and Albuminuria in Sub-Saharan African Populations - Brandenburg, J.-T., Govender, M. A., Winkler, C. A., Boua, P. R., Agongo, G., Fabian, J., Ramsay, M. Clin J Am Soc Nephrol
  Background and objectives Recessive inheritance of African-specific APOL1 kidney risk variants is associated with higher risk of nondiabetic kidney disease, progression to kidney failure, and early-onset albuminuria that precedes eGFR decline. The effect of APOL1 risk variants on kidney (...)
• 19:00
  PCSK9 and Cardiovascular Disease in Individuals with Moderately Decreased Kidney Function - Kheirkhah, A., Lamina, C., Kollerits, B., Schachtl-Riess, J. F., Schultheiss, U. T., Forer, L., Sekula, P., Kotsis, F., Eckardt, K.-U., Kronenberg, F., for the GCKD Investigators, GCKD Investigators, Eckardt, Meiselbach, Schneider, Schiffer, Prokosch, Ba?rthlein, Beck, Reis, Ekici, Becker, Becker-Grosspitsch, Alberth-Schmidt, Hausknecht, Weigel, Walz, Ko?ttgen, Schultheiss, Kotsis, Meder, Mitsch, Reinhard, Floege, Saritas, Schaeffner, Baid-Agrawal, Theisen, Haller, Menne, Zeier, Sommerer, Theilinger, Wolf, Busch, Paul, Sitter, Wanner, Krane, Bo?rner-Klein, Bauer, Kronenberg, (...) Clin J Am Soc Nephrol
  Background and objectives Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of lipid homeostasis. Studies investigating the association between PCSK9 and cardiovascular disease in large cohorts of patients with CKD are limited. Design, setting, participants, & (...)
• 19:00
  Evaluation of Conflicts of Interest among Participants of the Japanese Nephrology Clinical Practice Guideline - Murayama, A., Yamada, K., Yoshida, M., Kaneda, Y., Saito, H., Sawano, T., Shrestha, S., Shrestha, R., Tanimoto, T., Ozaki, A. Clin J Am Soc Nephrol
  Background and objectives Rigorous and transparent management strategies for conflicts of interest and clinical practice guidelines with the best available evidence are necessary for the development of nephrology guidelines. However, there was no study assessing financial and nonfinancial (...)
• 19:00
  Total Kidney Volume Measurements in ADPKD by 3D and Ellipsoid Ultrasound in Comparison with Magnetic Resonance Imaging - Akbari, P., Nasri, F., Deng, S. X., Khowaja, S., Lee, S. H., Warnica, W., Lu, H., Rattansingh, A., Atri, M., Khalili, K., York, P. Clin J Am Soc Nephrol
  Background and objectives Total kidney volume is a validated prognostic biomarker for autosomal dominant polycystic kidney disease. Total kidney volume by magnetic resonance imaging (MRI) and manual segmentation is considered the "reference standard," but it is time consuming and not readily (...)
• 19:00
  Fracture Risk of Sodium-Glucose Cotransporter-2 Inhibitors in Chronic Kidney Disease - Cowan, A., Jeyakumar, N., Kang, Y., Dixon, S. N., Garg, A. X., Naylor, K., Weir, M. A., Clemens, K. K. Clin J Am Soc Nephrol
  Background and objectives Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been associated with a higher risk of skeletal fractures in some randomized, placebo-controlled trials. Secondary hyperparathyroidism and increased bone turnover (also common in CKD) may contribute to the observed (...)
• 19:00
  Severity of COVID-19 after Vaccination among Hemodialysis Patients: An Observational Cohort Study - Ashby, D. R., Caplin, B., Corbett, R. W., Asgari, E., Kumar, N., Sarnowski, A., Hull, R., Makanjuola, D., Cole, N., Chen, J., Nyberg, S., McCafferty, K., Zaman, F., Cairns, H., Sharpe, C., Bramham, K., Motallebzadeh, R., Anwari, K. J., Salama, A. D., Banerjee, D., on behalf of the Pan-London COVID-19 Renal Audit Group, Pan-London COVID-19 Renal Audit Group, Ashby, Caplin, Corbett, Asgari, Kumar, Sarnowski, Hull, Makanjuola, Cole, Chen, Nyberg, McCafferty, Zaman, Cairns, Sharpe, Bramham, Motallebzadeh, Anwari, Salama, Banerjee, Ali, Antonelou, Bennet-Richards, Blunden, Booth, Charif, (...) Clin J Am Soc Nephrol
  Background and objectives Patients receiving hemodialysis are at high risk from coronavirus disease 2019 (COVID-19) and demonstrate impaired immune responses to vaccines. There have been several descriptions of their immunologic responses to severe acute respiratory syndrome coronavirus 2 (...)
• 19:00
  Medicare Bundled Payment Policy on Anemia Care, Major Adverse Cardiovascular Events, and Mortality among Adults Undergoing Hemodialysis - Park, H., Desai, R., Liu, X., Smith, S. M., Hincapie-Castillo, J., Henry, L., Goodin, A., Gopal, S., Pepine, C. J., Mohandas, R. Clin J Am Soc Nephrol
  Background and objectives In 2011, the Centers for Medicare & Medicaid Services implemented bundling of all services for patients receiving dialysis, including erythropoietin-stimulating agents use, and the Food and Drug Administration recommended conservative erythropoietin-stimulating (...)
• 19:00
  Variation in Peritoneal Dialysis Time on Therapy by Country: Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study - Lambie, M., Zhao, J., McCullough, K., Davies, S. J., Kawanishi, H., Johnson, D. W., Sloand, J. A., Sanabria, M., Kanjanabuch, T., Kim, Y.-L., Shen, J. I., Pisoni, R. L., Robinson, B. M., Perl, J., the PDOPPS Steering Committee, PDOPPS Steering Committee, Johnson, Perl, Kawanishi, Kim, Kanjanabuch, Davies, Bernardo, Pisoni, Robinson, Shen, Badve, Boudville, Brown, Chow, Collins, Morton, Wilson, Vychytil, Van Biesen, Figueiredo, de Moraes, Brunier, Jain, Jassal, Nessim, Oliver, Price, Quinn, Fang, Szeto, Wang, Fukasawa, Ito, Ryuzaki, Tomo, Manzano, Marshall, Ljungman, Boongird, Boonyakrai, (...) Clin J Am Soc Nephrol
  Background and objectives Quantifying contemporary peritoneal dialysis time on therapy is important for patients and providers. We describe time on peritoneal dialysis in the context of outcomes of hemodialysis transfer, death, and kidney transplantation on the basis of the multinational, (...)
• 19:00
  Humoral Response to Third Dose of SARS-CoV-2 Vaccines in the CKD Spectrum - Quiroga, B., Soler, M. J., Ortiz, A., Orero, E., Tejedor, S., Mantecon, C. J. J., Gomez Perez, V. O., Marin Franco, A. J., Alfaro Sanchez, C., Puerta Carretero, M., Jaldo Rodriguez, M. T., Carnerero Di Riso, M. A., Martinez, S., Gonzalez, C. C., Cervienka, M., Macias Carmona, N., Arroyo, D., Perez del Valle, K. M., de Arriba, G., Mazuecos, A., Cazorla, J. M., Pereira, M., Gonzalez Parra, E., Sanchez Marquez, M. G., Lancho Novillo, C., Toyos Ruiz, C., Aguilar Cervera, M. C., Munoz Ramos, P., Sanchez Horrillo, A., Jimeno Martin, I., Toapanta, N., Cigarran Guldris, S., Folgueiras Lopez, M., (...) Clin J Am Soc Nephrol
• 19:00
  Correction: Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD: A Randomized Controlled Trial Clin J Am Soc Nephrol
• 19:00
  Statement of Clarification: Chronic Kidney Disease from Polyvinylpyrrolidone Deposition in Persons with Intravenous Drug Use Clin J Am Soc Nephrol
• 19:00
  Sepsis Management for the Nephrologist - Patel, S., Puri, N., Dellinger, R. P. Clin J Am Soc Nephrol
  The definition of sepsis has evolved significantly over the past three decades. Today, sepsis is defined as a dysregulated host immune response to microbial invasion leading to end organ dysfunction. Septic shock is characterized by hypotension requiring vasopressors after adequate fluid (...)
• 19:00
  Mechanical Circulatory Support: Primer for Consultant Specialists - Tam, C. W., Shen, L., Zeidman, A. D., Srivastava, A., Ivascu, N. S. Clin J Am Soc Nephrol
  Mechanical life support therapies exist in many forms to temporarily replace the function of vital organs. Generally speaking, these tools are supportive therapy to allow for organ recovery but, at times, require transition to long-term mechanical support. This review will examine nonrenal (...)
• 19:00
  Hypertension with Kidney Failure - Rivara, M. B., Bansal, N. Clin J Am Soc Nephrol
• 19:00
  The Role of Glucagon-Like Peptide 1 (GLP-1) Receptor Agonists in the Prevention and Treatment of Diabetic Kidney Disease: Insights from the AMPLITUDE-O Trial - Tommerdahl, K. L., Kendrick, J., Bjornstad, P. Clin J Am Soc Nephrol
• 19:00
  Endothelin Receptor Antagonists for Kidney Protection: Lessons from the SONAR Trial - Heerspink, H. J. L., de Zeeuw, D. Clin J Am Soc Nephrol
• 19:00
  Cannabinoids for Symptom Management in Patients with Kidney Failure: A Narrative Review - Worth, H., OHara, D. V., Agarwal, N., Collister, D., Brennan, F., Smyth, B. Clin J Am Soc Nephrol
  People with kidney failure can experience a range of symptoms that lead to suffering and poor quality of life. Available therapies are limited, and evidence for new treatment options is sparse, often resulting in incomplete relief of symptoms. There is growing interest in the potential for (...)
• 19:00
  Electrolyte and Acid-Base Disorders Associated with Cancer Immunotherapy - Uppal, N. N., Workeneh, B. T., Rondon-Berrios, H., Jhaveri, K. D. Clin J Am Soc Nephrol
  Novel immunotherapy drugs have changed the landscape of cancer medicine. Immune checkpoint inhibitors and chimeric antigen receptor T cells are being used and investigated in almost all types of cancers. Immune-related adverse events have been associated with immunotherapies. AKI has been the (...)

6 June

Stroke https://www.ahajournals.org/

• 11:00
  Use of Lipid-Lowering Drugs After Intracerebral Hemorrhage - Ashkan Shoamanesh Magdy Selim Department of Medicine, McMaster University, Population Health Research Institute, Hamilton, ON, Canada (A.S.). Stroke Division, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (M.S.). Stroke
  Stroke, Volume 53, Issue 7, Page 2161-2170, July 1, 2022. Hyperlipidemia is common in patients with intracerebral hemorrhage (ICH). Accumulating evidence indicates that patients with ICH are at risk for future hemorrhage recurrence, cardiovascular disease, and ischemic stroke and highlights the (...) (Stroke)

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

• 12:04
  Impact of the Obesity Paradox Between Sexes on In?Hospital Mortality in Cardiogenic Shock: A Retrospective Cohort Study - Woochan Kwon, Seung Hun Lee , Jeong Hoon Yang , Ki Hong Choi , Taek Kyu Park , Joo Myung Lee , Young Bin Song , Joo?Yong Hahn , Seung?Hyuk Choi , Chul?Min Ahn , Young?Guk Ko , Cheol Woong Yu , Woo Jin Jang , Hyun?Joong Kim , Sung Uk Kwon , Jin?Ok Jeong , Sang?Don Park , Sungsoo Cho , Jang?Whan Bae , and Hyeon?Cheol Gwon 1Division of Cardiology Department of Medicine Heart Vascular Stroke InstituteSamsung Medical CenterSungkyunkwan University School of Medicine Seoul Republic of Korea 2Division of Cardiology Department of Internal Medicine Chonnam National University Hospital Gwangju (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundSeveral studies have shown that obesity is associated with better outcomes in patients with cardiogenic shock (CS). Although this phenomenon, the “obesity paradox,” reportedly manifests differently based on (...) (Journal of the American Heart Association)
• 12:03
  Is There an Obesity Paradox in Cardiogenic Shock? - Carl J. Lavie, Adrian daSilva?deAbreu , Hector O. Ventura , and Mandeep R. Mehra 1John Ochsner Heart and Vascular InstituteOchsner Clinical School ? The University of Queensland School of Medicine New Orleans LA 2Section of Cardiovascular Medicine Yale School of MedicineHeart and Vascular CenterYale?New Haven Hospital New Haven CT 3Brigham and Women’s Hospital and Harvard Medical School Boston MA J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. (Journal of the American Heart Association)
• 12:02
  Cardiac Magnetic Resonance Imaging–Based Screening for Cardiac Sarcoidosis in Patients With Atrioventricular Block Requiring Temporary Pacing - Aino?Maija Vuorinen, Jukka Lehtonen , Sami Pakarinen , Miia Holmström , Sari Kivistö , and Touko Kaasalainen 1Radiology HUS Diagnostic CenterUniversity of Helsinki and Helsinki University Hospital Helsinki Finland 2Heart and Lung Center University of Helsinki and Helsinki University Hospital Helsinki Finland 3Haartman HospitalUniversity of Helsinki and Helsinki University Hospital Helsinki Finland J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundSome myocardial diseases, such as cardiac sarcoidosis, predispose to complete atrioventricular block. The European Society of Cardiology Guidelines on cardiac pacing in 2021 recommend myocardial disease (...) (Journal of the American Heart Association)
• 12:02
  Managing Patients With Advanced Atrioventricular Block: The Essential Role of Cardiovascular Magnetic Resonance Imaging for Timely and Accurate Diagnosis - Lisa von Wald, and Chetan Shenoy 1Cardiovascular Division Department of Medicine University of Minnesota Medical School Minneapolis MN J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. (Journal of the American Heart Association)
• 12:01
  Idiopathic Recurrent Pericarditis: Not Really So Idiopathic? - François Roubille, Clément Delmas , and Camille Roubille 1Cardiology Department INI?CRT PhyMedExp INSERM CNRS CHU de MontpellierUniversité de Montpellier France 2Intensive Cardiac Care Unit Rangueil University Hospital/Institute of Metabolic and Cardiovascular Diseases UMR?1048 National Institute of Health and Medical Research Toulouse France 3Department of Internal Medicine PhyMedExp CHU MontpellierMontpellier University Montpellier France J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. (Journal of the American Heart Association)
• 12:01
  Pericarditis and Autoinflammation: A Clinical and Genetic Analysis of Patients With Idiopathic Recurrent Pericarditis and Monogenic Autoinflammatory Diseases at a National Referral Center - Claire J. Peet, Dorota Rowczenio , Ebun Omoyinmi , Charalampia Papadopoulou , Bella Ruth R. Mapalo , Michael R. Wood , Francesca Capon , and Helen J. Lachmann 1National Amyloidosis Centre Royal Free London NHS Foundation Trust & Division of Medicine University, College London London United Kingdom 2Department of Medical and Molecular Genetics King’s College London London United Kingdom J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundIdiopathic recurrent pericarditis (IRP) is an orphan disease that carries significant morbidity, partly driven by corticosteroid dependence. Innate immune modulators, colchicine and anti?interleukin?1 agents, (...) (Journal of the American Heart Association)
• 12:00
  Arrhythmogenesis and Prolonged Repolarization From Synthetic Opioids: Finally Sorted? - Lee L. Eckhardt 1Department of Medicine University of Wisconsin?Madison Madison WI J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. (Journal of the American Heart Association)
• 11:59
  Methadone Blockade of Cardiac Inward Rectifier K+ Current Augments Membrane Instability and Amplifies U Waves on Surface ECGs: A Translational Study - Michael G. Klein, Mori J. Krantz , Naheed Fatima , Ashlie Watters , Dayan Colon?Sanchez , Robert M. Geiger , Robert E. Goldstein , Soroosh Solhjoo , Philip S. Mehler , Thomas P. Flagg , and Mark C. Haigney 1Cardiology Division Department of Medicine Uniformed Services University Bethesda MD 2Department of Anatomy, Physiology & Genetics Uniformed Services University Bethesda MD 3Psychiatry Division Outpatient Behavioral Health Services, Denver Health, & University of Colorado School of Medicine Denver CO 4Denver Health Medical Center Cardiology Division Denver CO 5ACUTE at Denver Health (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundMethadone is associated with a disproportionate risk of sudden death and ventricular tachyarrhythmia despite only modest inhibition of delayed rectifier K+current (IKr),the principal mechanism of (...) (Journal of the American Heart Association)

Hypertension https://www.ahajournals.org/

• 11:00
  Uric Acid and Hypertension: a Review of Evidence and Future Perspectives for the Management of Cardiovascular Risk - Claudio Borghi Davide Agnoletti Arrigo Francesco Giuseppe Cicero Empar Lurbe Agostino Virdis Department of Medical and Surgical Science-IRCCS S.Orsola, University of Bologna, Italy (C.B., D.A., A.F.G.C.). Department of Pediatrics, University of Valencia, Spain (E.L.). Department of Clinical and Experimental Medicine, University of Pisa, Italy (A.V.). Hypertension
  Hypertension, Ahead of Print. Uric acid is the final product of purine metabolism, and its increased serum levels have been directly involved in the pathogenesis and natural history of hypertension. The relationship between elevated uric acid and hypertension has been proven in both animals and (...) (Hypertension)

Circulation http://ahajournals.org/

• 08:00
  Single Nucleus Transcriptomics: Apical Resection in Newborn Pigs Extends the Time Window of Cardiomyocyte Proliferation and Myocardial Regeneration - Yuji Nakada Yang Zhou Wuming Gong Eric Y. Zhang Erik Skie Thanh Nguyen Yuhua Wei Meng Zhao Wangping Chen Jiacheng Sun S. Naqi Raza Jake Y. Chen Gregory P. Walcott Daniel J. Garry Jianyi (Jay) Zhang Department of Biomedical Engineering (Y.N., Y.Z., E.Y.Z., Y.W., M.Z., W.C., J.S., S.N.R., J.Z.), University of Alabama at Birmingham. Informatics Institute (T.N., J.Y.C.), University of Alabama at Birmingham. Department of Medicine, Cardiovascular Disease (G.P.W., J.Z.), University of Alabama at Birmingham. Department of Medicine, School of Medicine, University of Minnesota, Minneapolis (W.G., (...) Circulation
  Circulation, Volume 145, Issue 23, Page 1744-1747, June 7, 2022. (Circulation)
• 08:00
  Evidence Builds for Catheter Ablation for Atrial Fibrillation and Heart Failure - Sean D. Pokorney Christopher B. Granger Duke Clinical Research Institute and the Division of Cardiology, Duke University School of Medicine, Durham, NC. Circulation
  Circulation, Volume 145, Issue 23, Page 1705-1707, June 7, 2022. (Circulation)
• 08:00
  Histone Acetyltransferases in Smooth Muscle Cell Phenotype Switching: Redundant No Longer - Iris Z. Jaffe Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA. Circulation
  Circulation, Volume 145, Issue 23, Page 1738-1740, June 7, 2022. (Circulation)

Eur Heart J https://academic.oup.com/site_5375/

• 02:00
  New avenues in the prevention of sudden cardiac death - Crea F. Eur Heart J

Nature Reviews Nephrology http://www.nature.com/ncpneph/

• 00:00
  Synchronization in the renal microcirculation - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00595-8Synchronization in the renal microcirculation (Nature Reviews Nephrology, Published online: 2022-06-06; | doi:10.1038/s41581-022-00595-8)
• 00:00
  P3H2 in glomerular basement membrane regulation - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00594-9P3H2 in glomerular basement membrane regulation (Nature Reviews Nephrology, Published online: 2022-06-06; | doi:10.1038/s41581-022-00594-9)
• 00:00
  Important roles of mechanical force and hydraulic pressure in kidney function - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00593-wImportant roles of mechanical force and hydraulic pressure in kidney function (Nature Reviews Nephrology, Published online: 2022-06-06; | doi:10.1038/s41581-022-00593-w)
• 00:00
  Dietary protection of proximal tubules in diabetes - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00591-yDietary protection of proximal tubules in diabetes (Nature Reviews Nephrology, Published online: 2022-06-06; | doi:10.1038/s41581-022-00591-y)
• 00:00
  Benefits of actin cytoskeleton stabilization - Susan J. Allison Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00596-7Benefits of actin cytoskeleton stabilization (Nature Reviews Nephrology, Published online: 2022-06-06; | doi:10.1038/s41581-022-00596-7)
• 00:00
  Patient-centred clinical trial design - Allison Tong, Nicole Scholes-Robertson, Carmel Hawley, Andrea K. Viecelli, Simon A. Carter, Adeera Levin, Brenda R. Hemmelgarn, Tess Harris, Jonathan C. Craig Nature Reviews Nephrology
  Nature Reviews Nephrology, Published online: 06 June 2022; doi:10.1038/s41581-022-00585-wMeaningful involvement of patients in clinical trial design could lead to improvements in participant recruitment and retention, the uptake of the tested intervention and the impact of the findings. Here, (...) (Nature Reviews Nephrology, Published online: 2022-06-06; | doi:10.1038/s41581-022-00585-w)

5 June

Diabetologia http://link.springer.com/

• 00:00
  Obesity in late adolescence and incident type 1 diabetes in young adulthood Diabetologia
  Abstract Aims/hypothesis Studies in children have reported an association between increased BMI and risk for developing type 1 diabetes, but evidence in late adolescence is limited. We studied the association between BMI in late adolescence and incident type 1 diabetes in young adulthood. (...)

3 June

Stroke https://www.ahajournals.org/

• 11:00
  Rho-Kinase Inhibition Improves the Outcome of Focal Subcortical White Matter Lesions - Sanem A. Aykan Hongyu Xie Yi Zheng David Y. Chung Sreekanth Kura James Han Lai Taylan D. Erdogan Andreia Morais Isra Tamim Damla Yagmur Hidehiro Ishikawa Ken Arai M. Abbas Yaseen David A. Boas Sava Sakadzic Cenk Ayata Neurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Charlestown (S.A.A., H.X., Y.Z., D.Y.C., J.H.L., T.D.E., A.M., I.T., D.Y., C.A.). Neuroprotection Research Laboratory, Department of Radiology and Neurology (H.I., K.A.), Massachusetts General Hospital, Harvard Medical School, Charlestown. Department of Rehabilitation, Huashan Hospital, (...) Stroke
  Stroke, Volume 53, Issue 7, Page 2369-2376, July 1, 2022. Background:Subcortical white matter lesions are exceedingly common in cerebral small vessel disease and lead to significant cumulative disability without an available treatment. Here, we tested a rho-kinase inhibitor on functional (...) (Stroke)
• 11:00
  Delayed Infiltration of Peripheral Monocyte Contributes to Phagocytosis and Transneuronal Degeneration in Chronic Stroke - Keun Woo Park Hyunwoo Ju Il-doo Kim John W. Cave Yang Guo Wei Wang Zhuhao Wu Sunghee Cho Burke Neurological Institute, White Plains, NY (K.W.P., H.J., I.-d.K., Y.G., S.C.). InVitro Cell Research LLC, Englewood, NJ (J.W.C.). Department of Cell, Developmental and Regenerative Biology and Department of Neuroscience, Icahn School of Medicine at Mount Sinai, NY (W.W., Z.W.). Feil Brain Mind Research Institute, Weill Cornell Medicine, NY (K.W.P., S.C.). Stroke
  Stroke, Volume 53, Issue 7, Page 2377-2388, July 1, 2022. Background:Mononuclear phagocytes, including monocyte-derived macrophages (MDMs) and microglia, contribute to infarct development as well as tissue repair in the postischemic brain. Here, we identify the origin and function of MDMs in (...) (Stroke)
• 04:24
  Review of Long-Term Blood Pressure Control After Intracerebral Hemorrhage: Challenges and Opportunities - Michael T. Mullen Craig S. Anderson Department of Neurology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (M.T.M.). The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, Australia (C.S.A.). The George Institute China at Peking University Health Sciences Center, Beijing (C.S.A.). Stroke
  Stroke, Volume 53, Issue 7, Page 2142-2151, July 1, 2022. Blood pressure (BP) is the most important modifiable risk factor for intracerebral hemorrhage (ICH). Elevated BP is associated with an increased risk of ICH, worse outcome after ICH, and in survivors, higher risks of recurrent ICH, (...) (Stroke)

Kidney Int http://www.kidney-international.org/

• 00:00
  Blood pressure adaptation in vertebrates: comparative biology - Akira Nishiyama, Kento Kitada, Miwa Suzuki Kidney Int
  With evolution from water to land, the osmotic regulation of body fluids and cardiovascular systems of vertebrates evolved to cope with dryness and gravity. While aquatic vertebrates can use buoyancy to compensate for the effects of gravity, terrestrial vertebrates cannot and must circulate (...) (Kidney International (2022))

Hypertension https://www.ahajournals.org/

• 11:00
  Effect of Renin-Angiotensin-Aldosterone System Inhibitors on the Rupture Risk Among Hypertensive Patients With Intracranial Aneurysms - Ping Zhong Zhiwen Lu Zhangyu Li Tianxiao Li Qing Lan Jianmin Liu Zhanxiang Wang Sifang Chen Qinghai Huang Department of Neurosurgery (P.Z., Z. Li, S.C.), School of Medicine, Xiamen University, China. BE and Phase I Clinical Trial Center (P.Z.), School of Medicine, Xiamen University, China. Department of Neurosurgery, Xiamen Key Laboratory of Brain Center (Z.W.), School of Medicine, Xiamen University, China. The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University and Department of Neuroscience, Institute of Neurosurgery (Z.W.), School of Medicine, Xiamen (...) Hypertension
  Hypertension, Volume 79, Issue 7, Page 1475-1486, July 1, 2022. Background:Mounting experimental evidence supports the concept that the RAAS (renin-angiotensin-aldosterone system) is involved in the pathogenesis of intracranial aneurysm rupture. However, whether RAAS inhibitors could reduce the (...) (Hypertension)

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

• 12:41
  Circulating S?Glutathionylated cMyBP?C as a Biomarker for Cardiac Diastolic Dysfunction - Xiaoxu Zhou, Euy?Myoung Jeong , Hong Liu , Bahaa Kaseer , Man Liu , Suvash Shrestha , Hafiz Imran , Kylie Kavanagh , Ning Jiang , Lori?Ann Desimone , Feng Feng , Guangbin Shi , Go Eun Jeong , Anyu Zhou , Philip Stockwell , and Samuel C. Dudley 1Division of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota Minneapolis MN 2Lifespan Cardiovascular Research Center Brown University Providence RI 3Department of Pathology Wake Forest Baptist Medical Center Winston?Salem NC 4Department of Biology and Medicine Brown University Providence (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundcMyBP?C (Cardiac myosin binding protein?C) regulates cardiac contraction and relaxation. Previously, we demonstrated that elevated myocardial S?glutathionylation of cMyBP?C correlates with diastolic dysfunction (...) (Journal of the American Heart Association)
• 12:40
  Relationship Between Risk of Atherosclerotic Cardiovascular Disease, Inflammation, and Coronary Microvascular Dysfunction in Rheumatoid Arthritis - Brittany Weber, Dana Weisenfeld , Thany Seyok , Sicong Huang , Elena Massarotti , Leanne Barrett , Courtney Bibbo , Daniel H. Solomon , Jorge Plutzky , Marcy Bolster , Marcelo Di Carli , and Katherine P. Liao 1Heart and Vascular Center Division of Cardiovascular Medicine Department of Medicine Brigham and Women’s HospitalHarvard Medical School Boston MA 2Division of Rheumatology, Inflammation, and Immunity Brigham and Women’s Hospital Harvard Medical School Boston MA 3Division of Rheumatology, Allergy and Immunology Massachusetts General HospitalHarvard Medical School Boston MA (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. (Journal of the American Heart Association)
• 12:40
  Prognostic Implications of Prestent Pullback Pressure Gradient and Poststent Quantitative Flow Ratio in Patients Undergoing Percutaneous Coronary Intervention - Neng Dai, Sheng Yuan , Kefei Dou , Rui Zhang , Nan Hu , Jining He , Changdong Guan , Tongqiang Zou , Zheng Qiao , Shaofeng Duan , Lihua Xie , Yongfu Yu , Yingmei Zhang , Bo Xu , and Junbo Ge 1Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular Diseases Shanghai China 2National Clinical Research Center for Interventional Medicine Shanghai China 3State Key Laboratory of Cardiovascular Disease Beijing China 4Cardiometabolic Medicine Center Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundCoronary diffuse disease associates with poor outcomes, but little is known about its role after percutaneous coronary intervention (PCI). We aimed to investigate the prognostic implication of pre?PCI focal (...) (Journal of the American Heart Association)
• 12:40
  Predictors of Recurrent Stroke After Embolic Stroke of Undetermined Source in the RE?SPECT ESUS Trial - Victor J. Del Brutto, Han?Christoph Diener , J. Donald Easton , Christopher B. Granger , Lisa Cronin , Eva Kleine , Claudia Grauer , Martina Brueckmann , Kazunori Toyoda , Peter D. Schellinger , Philippe Lyrer , Carlos A. Molina , Aurauma Chutinet , Christopher F. Bladin , Conrado J. Estol , and Ralph L. Sacco 1Department of Neurology University of Miami Miller School of Medicine Miami FL 2Department of Neurology University Duisburg?Essen Essen Germany 3Department of Neurology University of California San Francisco CA 4Duke Clinical Research Institute Durham NC 5Boehringer Ingelheim (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundWe sought to determine recurrent stroke predictors among patients with embolic strokes of undetermined source (ESUS).Methods and ResultsWe applied Cox proportional hazards models to identify clinical (...) (Journal of the American Heart Association)
• 12:40
  Machine Learning–Based Risk Model for Predicting Early Mortality After Surgery for Infective Endocarditis - Li Luo, Sui?qing Huang , Chuang Liu , Quan Liu , Shuohui Dong , Yuan Yue , Kai?zheng Liu , Lin Huang , Shun?jun Wang , Hua?yang Li , Shaoyi Zheng , and Zhong?kai Wu 1Department of Cardiac Surgery The First Affiliated Hospital of Sun Yat?sen University Guangzhou P. R. China 2School of Computer Science and Technology Xidian University Xi’an P. R. China 3Department of General Surgery Qianfoshan HospitalShandong University Jinan P. R. China 4Department of Cardiovascular Surgery Nanfang HospitalSouthern Medical University Guangzhou P. R. (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundThe early mortality after surgery for infective endocarditis is high. Although risk models help identify patients at high risk, most current scoring systems are inaccurate or inconvenient. The objective of (...) (Journal of the American Heart Association)
• 12:40
  p53?Dependent Mitochondrial Compensation in Heart Failure With Preserved Ejection Fraction - Xiaonan Chen, Hao Lin , Weiyao Xiong , Jianan Pan , Shuying Huang , Shan Xu , Shufang He , Ming Lei , Alex Chia Yu Chang , and Huili Zhang 1Department of Cardiology Ninth People’s HospitalShanghai Jiao Tong University School of Medicine Shanghai China 2Shanghai Institute of Precision MedicineNinth People’s HospitalShanghai Jiao Tong University School of Medicine Shanghai China J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundHeart failure with preserved ejection fraction (HFpEF) accounts for 50% of patients with heart failure. Clinically, HFpEF prevalence shows age and gender biases. Although the majority of patients with HFpEF (...) (Journal of the American Heart Association)
• 12:39
  Cost?Effectiveness of Cilostazol Added to Aspirin or Clopidogrel for Secondary Prevention After Noncardioembolic Stroke - Lily W. Zhou, Lironn Kraler , Adam de Havenon , and Maarten G. Lansberg 1Stanford Stroke Center Stanford University Palo Alto CA 2Division of Neurology and Vancouver Stroke Program University of British Columbia Vancouver British Columbia Canada 3Department of Neurology Yale University New Haven CT J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundThe objective of the study was to assess the cost?effectiveness of cilostazol (a selective phosphodiesterase 3 inhibitor) added to aspirin or clopidogrel for secondary stroke prevention in patients with (...) (Journal of the American Heart Association)
• 12:39
  Amiodarone Use and All?Cause Mortality in Patients With a Continuous?Flow Left Ventricular Assist Device - Rakesh Gopinathannair, Naga Venkata K. Pothineni , Jaimin R. Trivedi , Henri Roukoz , Jennifer Cowger , Mustafa M. Ahmed , Adarsh Bhan , Ashwin K. Ravichandran , Geetha Bhat , Amin Al Ahmad , Andrea Natale , Luigi Di Biase , Mark S. Slaughter , and Dhanunjaya Lakkireddy 1Kansas City Heart Rhythm Institute Overland Park KS 2Department of Cardiothoracic Surgery University of Louisville Louisville KY 3Division of Cardiology University of Minnesota Minneapolis MN 4Division of Cardiology Henry Ford Hospital Detroit MI 5Division of Cardiology University of Florida Gainesville FL 6Division of (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundAtrial and ventricular arrhythmias are commonly encountered in patients with advanced heart failure, with amiodarone being the most commonly used antiarrhythmic drug in continuous?flow left ventricular assist (...) (Journal of the American Heart Association)
• 12:39
  Clinician Responses to a Clinical Decision Support Advisory for High Risk of Torsades de Pointes - Tyler Gallo, C. William Heise , Raymond L. Woosley , James E. Tisdale , Malinda S. Tan , Sheila M. Gephart , Corneliu C. Antonescu , and Daniel C. Malone 1Division of Clinical Data Analytics and Decision Support University of Arizona College of Medicine–Phoenix AZ 2Department of Pharmacy Practice and Science University of Arizona College of Pharmacy Phoenix AZ 3Department of Medical Toxicology Banner–University Medical Center Phoenix Phoenix AZ 4Arizona Center for Education and Research on Therapeutics Oro Valley AZ 5Department of Pharmacy Practice College of Pharmacy Purdue University (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundTorsade de pointes (TdP) is a potentially fatal cardiac arrhythmia that is often drug induced. Clinical decision support (CDS) may help minimize TdP risk by guiding decision making in patients at risk. CDS (...) (Journal of the American Heart Association)
• 12:39
  Pyruvate Kinase M2 Protects Heart from Pressure Overload?Induced Heart Failure by Phosphorylating RAC1 - Le Ni, Bowen Lin , Lingjie Hu , Ruoyu Zhang , Fengmei Fu , Meiting Shen , Jian Yang , and Dan Shi 1Department of Cardiology Shanghai East HospitalTongji University School of Medicine Shanghai China 2Key Laboratory of Arrhythmias of the Ministry of Education of China Shanghai East HospitalTongji University School of Medicine Shanghai China 3Department of Cell Biology Tongji University School of Medicine Shanghai China 4Jinzhou Medical University Liaoning China 5Institute of Medical Genetics Tongji University Shanghai (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundHeart failure, caused by sustained pressure overload, remains a major public health problem. PKM (pyruvate kinase M) acts as a rate?limiting enzyme of glycolysis. PKM2 (pyruvate kinase M2), an alternative (...) (Journal of the American Heart Association)
• 12:38
  Association Between Systolic Blood Pressure Variability and Major Adverse Cardiovascular Events in Korean Patients With Chronic Kidney Disease: Findings From KNOW?CKD - Cheol Ho Park, Hyung Woo Kim , Young Su Joo , Jung Tak Park , Tae Ik Chang , Tae?Hyun Yoo , Sue Kyung Park , Dong?Wan Chae , Wookyung Chung , Yong?Soo Kim , Kook?Hwan Oh , Shin?Wook Kang , Seung Hyeok Han , and 1Department of Internal Medicine College of MedicineInstitute of Kidney Disease ResearchYonsei University Seoul Republic of Korea 2Department of Internal Medicine National Health Insurance Service Medical CenterIlsan Hospital Goyangshi Republic of Korea 3Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea 4Department of Internal (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundWhether visit?to?visit systolic blood pressure (SBP) variability can predict major adverse cardiovascular events (MACE) in patients with chronic kidney disease is unclear.Methods and ResultsWe investigated the (...) (Journal of the American Heart Association)
• 12:38
  Subcutaneous Versus Transvenous Implantable Defibrillator Therapy: A Systematic Review and Meta?Analysis of Randomized Trials and Propensity Score–Matched Studies - Khi Yung Fong, Colin Jun Rong Ng , Yue Wang , Colin Yeo , and Vern Hsen Tan 1Yong Loo Lin School of MedicineNational University of Singapore Singapore 2Department of Cardiology Changi General Hospital Singapore J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundSubcutaneous implantable cardioverter?defibrillators (S?ICDs) have been of great interest as an alternative to transvenous implantable cardioverter?defibrillators (TV?ICDs). No meta?analyses synthesizing data (...) (Journal of the American Heart Association)
• 12:38
  Risk Burden of Coronary Perforation in Chronic Total Occlusion Recanalization: Latin American CTO Registry Analysis - Marcelo Harada Ribeiro, Carlos M. Campos , Lucio Padilla , Antonio Carlos B. da Silva , João Eduardo T. de Paula , Marco Alcantara , Ricardo Santiago , Franklin Hanna , Franciele R. da Silva , Karlyse C. Belli , Lorenzo Azzalini , Pedro P. de Oliveira , Gustavo N. Araujo , Vincenzo Sucato , Kambis Mashayekhi , Alfredo R. Galassi , Alexandre Abizaid , and Alexandre Quadros 1Heart Institute (InCor)Universidade de São Paulo (USP) São Paulo Brazil 2Instituto Prevent Senior, Sao Paulo São Paulo Brazil 3Interventional Cardiology Division Instituto Cardiovascular de Buenos Aires Buenos Aires (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundCoronary perforation is a life?threatening complication of acute percutaneous coronary intervention (PCI) for chronic total occlusions (CTO), but data on midterm outcomes are limited.Methods and ResultsData (...) (Journal of the American Heart Association)
• 12:38
  Genetic Determinants of Body Mass Index and Fasting Glucose Are Mediators of Grade 1 Diastolic Dysfunction - Nataraja Sarma Vaitinadin, Mingjian Shi , Christian M. Shaffer , Eric Farber?Eger , Brandon D. Lowery , Vineet Agrawal , Deepak K. Gupta , Dan M. Roden , Quinn S. Wells , and Jonathan D. Mosley 1Department of Medicine Vanderbilt University Medical Center Nashville TN 2Department of Biomedical Informatics Vanderbilt University Medical Center Nashville TN 3Department of Pharmacology Vanderbilt University Nashville TN J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundEarly (grade 1) cardiac left ventricular diastolic dysfunction (G1DD) increases the risk for heart failure with preserved ejection fraction and may improve with aggressive risk factor modification. Type 2 (...) (Journal of the American Heart Association)
• 12:37
  Neutrophil?to?Lymphocyte Ratios in Patients Undergoing Aortic Valve Replacement: The PARTNER Trials and Registries - Bahira Shahim, Björn Redfors , Brian R. Lindman , Shmuel Chen , Torsten Dahlen , Tamim Nazif , Samir Kapadia , Zachary M. Gertz , Aaron C. Crowley , Ditian Li , Vinod H. Thourani , Susheel K. Kodali , Alan Zajarias , Vasilis C. Babaliaros , Robert A. Guyton , Sammy Elmariah , Howard C. Herrmann , David J. Cohen , Michael J. Mack , Craig R. Smith , Martin B. Leon , and Isaac George 1Clinical Trials Center Cardiovascular Research Foundation New York NY 2Division of Cardiology NewYork?Presbyterian Hospital/Columbia University Medical Center New York NY 3Structural Heart and Valve (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundThe neutrophil?to?lymphocyte ratio (NLR) as a marker of systemic inflammation has been associated with worse prognosis in several chronic disease states, including heart failure. However, few data exist on the (...) (Journal of the American Heart Association)
• 12:37
  Hydrophilic Versus Lipophilic Statin Treatments in Patients With Renal Impairment After Acute Myocardial Infarction - Min Hye Kang, Weon Kim , Jin Sug Kim , Kyung Hwan Jeong , Myung Ho Jeong , Jin?Yong Hwang , Seung Ho Hur , and Hyeon Seok Hwang 1Division of Nephrology Department of Internal Medicine Kyung Hee University Seoul Republic of Korea 2Division of Cardiology Department of Internal Medicine Kyung Hee University Seoul Republic of Korea 3Department of Internal Medicine and Heart Center Chonnam National University Hospital Gwangju Republic of Korea 4Department of Internal Medicine Gyeongsang National University Hospital Jinju Republic of Korea 5Division of Cardiology Keimyung University Medical (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundHydrophilic and lipophilic statins have similar efficacies in treating coronary artery disease. However, specific factors relevant to renal impairment and different arterial pathogeneses could modify the (...) (Journal of the American Heart Association)
• 12:36
  Lipoprotein(a) and Subclinical Vascular and Valvular Calcification on Cardiac Computed Tomography: The Atherosclerosis Risk in Communities Study - Olufunmilayo H. Obisesan, Minghao Kou , Frances M. Wang , Ellen Boakye , Yasuyuki Honda , S. M. Iftekhar Uddin , Omar Dzaye , Albert D. Osei , Olusola A. Orimoloye , Candace M. Howard?Claudio , Josef Coresh , Roger S. Blumenthal , Ron C. Hoogeveen , Matthew J. Budoff , Kunihiro Matsushita , Christie M. Ballantyne , and Michael J. Blaha 1Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease Baltimore MD 2Medstar Union Memorial Hospital Baltimore MD 3Tulane University School of Public Health and Tropical Medicine New Orleans LA 4Johns Hopkins Bloomberg School of Public (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundLipoprotein(a) (Lp(a)) is a potent causal risk factor for cardiovascular events and mortality. However, its relationship with subclinical atherosclerosis, as defined by arterial calcification, remains (...) (Journal of the American Heart Association)
• 12:36
  Intervention Adherence in REHAB?HF: Predictors and Relationship With Physical Function, Quality of Life, and Clinical Events - M. Benjamin Nelson, Olivia N. Gilbert , Pamela W. Duncan , Dalane W. Kitzman , Gordon R. Reeves , David J. Whellan , Robert J. Mentz , Haiying Chen , Leigh Ann Hewston , Karen M. Taylor , and Amy M. Pastva 1Department of Internal Medicine Section on Cardiovascular Medicine Wake Forest School of Medicine Winston?Salem NC 2Department of Neurology Wake Forest School of Medicine Winston?Salem NC 3Department of Internal MedicineSection on GeriatricsWake Forest School of Medicine Winston?Salem NC 4Novant Health Heart and Vascular Institute Charlotte NC 5Department of Medicine Sidney Kimmel (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundThe REHAB?HF (Rehabilitation Therapy in Older Acute Heart Failure Patients) trial showed that a novel, early, transitional, tailored, progressive, multidomain physical rehabilitation intervention improved (...) (Journal of the American Heart Association)
• 12:36
  Faculty Development Approaches for Life Support Courses: A Scoping Review - Ying?Chih Ko, Ming?Ju Hsieh , Adam Cheng , Kasper G. Lauridsen , Taylor L. Sawyer , Farhan Bhanji , Robert Greif 1Department of Emergency Medicine National Taiwan University Hospital Taipei Taiwan 2Departments of Pediatrics and Emergency Medicine University of Calgary Alberta Canada 3Research Center for Emergency Medicine Aarhus University Hospital Aarhus Denmark 4Emergency Department Randers Regional Hospital Randers Denmark 5Department of Anesthesiology and Critical Care Medicine Children's Hospital of Philadelphia Philadelphia PA 6University of Washington School of Medicine Seattle WA (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. The aim of this scoping review initiated by the Education, Implementation and Teams Task Force of the International Liaison Committee on Resuscitation was to identify faculty development approaches to improve (...) (Journal of the American Heart Association)
• 12:36
  Validation of the WATCH?DM and TRS?HFDM Risk Scores to Predict the Risk of Incident Hospitalization for Heart Failure Among Adults With Type 2 Diabetes: A Multicohort Analysis - Matthew W. Segar, Kershaw V. Patel , Anne S. Hellkamp , Muthiah Vaduganathan , Yuliya Lokhnygina , Jennifer B. Green , Siu?Hin Wan , Ahmed A. Kolkailah , Rury R. Holman , Eric D. Peterson , Vaishnavi Kannan , Duwayne L. Willett , Darren K. McGuire , and Ambarish Pandey 1Department of Cardiology Texas Heart Institute Houston TX 2Department of Cardiology Houston Methodist DeBakey Heart and Vascular Center Houston TX 3Duke Clinical Research Institute Duke University School of Medicine Durham NC 4Brigham and Women’s Hospital Heart and Vascular Center Department of Medicine Harvard Medical (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundThe WATCH?DM (weight [body mass index], age, hypertension, creatinine, high?density lipoprotein cholesterol, diabetes control [fasting plasma glucose], ECG QRS duration, myocardial infarction, and coronary (...) (Journal of the American Heart Association)
• 12:36
  Underuse of Catheter Ablation as First?Line Therapy for Supraventricular Tachycardia - Lucas Hollanda Oliveira, Mateus dos Santos Viana , Christian Moreno Luize , Ricardo Sobral de Carvalho , Claudio Cirenza , Cristiano de Oliveira Dietrich , Luis Claudio Correia , Claudio das Virgens , Juliana Medeiros Filgueiras , Mauricio Barreto , Emerson Porto , Enia Coutinho , and Ângelo de Paola 1From Clinical Cardiac Electrophysiology Federal University of São Paulo São Paulo Brazil 2Fundação Bahiana de Cardiologia Salvador Brazil 3Hospital Aliança Salvador Brazil 4Bahiana Medical and Public Health School Salvador Brazil 5Hospital Moriah São Paulo (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundCatheter ablation (CA) is a safe, effective, cost?effective technique and may be considered a first?line strategy for the treatment of symptomatic supraventricular tachycardias (SVT). Despite the high prospect (...) (Journal of the American Heart Association)
• 12:36
  Myocardial Iron Deficiency and Mitochondrial Dysfunction in Advanced Heart Failure in Humans - Hao Zhang, K. Lockhart Jamieson , Justin Grenier , Anish Nikhanj , Zeyu Tang , Faqi Wang , Shaohua Wang , Jonathan G. Seidman , Christine E. Seidman , Richard Thompson , John M. Seubert , and Gavin Y. Oudit 1Division of Cardiology Department of Medicine Faculty of Medicine and DentistryEdmonton Alberta Canada 2Mazankowski Alberta Heart Institute Edmonton Alberta Canada 3Department of Pharmacology Faculty of Medicine and DentistryEdmonton Alberta Canada 4Department of Biomedical Engineering Faculty of Medicine and DentistryEdmonton Alberta Canada 5Division of Cardiac Surgery Department of (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundMyocardial iron deficiency (MID) in heart failure (HF) remains largely unexplored. We aim to establish defining criterion for MID, evaluate its pathophysiological role, and evaluate the applicability of (...) (Journal of the American Heart Association)
• 12:34
  Potential Impact of 2017 American College of Cardiology/American Heart Association Hypertension Guideline on Contemporary Practice: A Cross?Sectional Analysis From NCDR PINNACLE Registry - Aliza Hussain, Salim S. Virani , Luke Zheng , Ty J. Gluckman , William B. Borden , Frederick A. Masoudi , and Thomas M. Maddox 1Section of Cardiology Department of Medicine Baylor College of Medicine Houston TX 2Section of Cardiology Michael E. DeBakey Veterans Affairs Hospital Houston TX 3BAIM Institute for Clinical Research Boston MA 4Center for Cardiovascular Analytics, Research and Data Science Providence Heart InstituteProvidence St Joseph Health Portland OR 5Department of Medicine George Washington University Washington DC 6Division of Cardiology University of Colorado Anschutz (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundClinical implications of change in the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) guideline on the diagnosis and management of hypertension, compared with recommendations by (...) (Journal of the American Heart Association)

Stroke https://www.ahajournals.org/

• 11:00
  Effect of Hypertension on Efficacy and Safety of Ticagrelor-Aspirin Versus Clopidogrel-Aspirin in Minor Stroke or Transient Ischemic Attack - Anxin Wang Xia Meng Xue Tian S. Claiborne Johnston Hao Li Philip M. Bath Yingting Zuo Xuewei Xie Jing Jing Jinxi Lin Yilong Wang Xingquan Zhao Zixiao Li Yong Jiang Liping Liu Feng Wang Yanxia Wang Panbing Huang Guofang Chen Yongjun Wang Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China. (A.W., X.M., H.L., X.X., J.J., J.L., Yilong Wang, X.Z., Z.L., Y.J., L.L., Yongjun Wang) China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, China. (A.W., X.M., H.L., X.X., J.J., J.L., Yilong Wang, X.Z., (...) Stroke
  Stroke, Ahead of Print. BACKGROUND:Hypertension is a risk factor of poor stroke outcomes and associated with antiplatelet resistance. This study aimed to explore the efficacy and safety of ticagrelor-aspirin versus clopidogrel-aspirin in patients with different hypertension status, using (...) (Stroke)

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

• 12:39
  Workers’ Activity Profiles Associated With Predicted 10?Year Cardiovascular Disease Risk - Aviroop Biswas, Cynthia Chen , Stephanie A. Prince , Peter M. Smith , and Cameron A. Mustard 1Institute for Work & Health Toronto Ontario Canada 2Dalla Lana School of Public Health University of Toronto Ontario Canada 3Centre for Surveillance and Applied Research Public Health Agency of CanadaOttawa Ontario Canada 4School of Epidemiology and Public Health Faculty of Medicine University of Ottawa Ontario Canada 5Department of Epidemiology and Preventive Medicine Monash University (...) J Am Heart Assoc
  Journal of the American Heart Association, Ahead of Print. BackgroundThere is a need to explore common activity patterns undertaken by workers and the association between these activity profiles and cardiovascular disease (CVD). This study explored the number and type of distinct profiles of (...) (Journal of the American Heart Association)

Hypertension https://www.ahajournals.org/

• 11:00
  Uric Acid Expression in Carotid Atherosclerotic Plaque and Serum Uric Acid Are Associated With Cerebrovascular Events - Valentina Nardi Federico Franchi Megha Prasad Erica M. Fatica Mariam P. Alexander Melanie C. Bois Josephine Lam Ravinder J. Singh Fredric B. Meyer Giuseppe Lanzino Yuning Xiong Esther Lutgens Lilach O. Lerman Amir Lerman Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. (V.N., F.F., M.P., J.L., Y.X., E.L., A.L.) Department of Laboratory of Medicine and Pathology, Mayo Clinic, Rochester, MN. (E.M.F., M.P.A., M.C.B., R.J.S.) Department of Neurosurgery, Mayo Clinic, Rochester, MN. (F.B.M., G.L.) Department of Nephrology and Hypertension, Mayo Clinic, Rochester, MN. (...) Hypertension
  Hypertension, Ahead of Print. Background:Uric acid (UA) concentration within carotid plaque and its association with cerebrovascular events have not been detected or quantified. Systemically, serum UA is a marker of inflammation and risk factor for atherosclerosis. However, its association with (...) (Hypertension)

Circulation http://ahajournals.org/

• 11:01
  Endovascular Treatment Versus Best Medical Management in Acute Basilar Artery Occlusion Strokes: Results From the ATTENTION Multicenter Registry - Chunrong Tao Adnan I. Qureshi Yamei Yin Jie Li Rui Li Pengfei Xu Jun Sun Geng Liao Xincan Yue Hongchao Shi Yongchang Liu Zhengfei Ma Jinghua Zhang Guodong Xiao Bo Xu Chenghua Xu Junfeng Su Wensheng Zhou Shuchun Huang Weimin Yang Hongbing Chen Wei Li Yongkun Li Dezhi Liu Chuanqing Yu Guangxiong Yuan ChaoBin Wan Wenbao Liang Chun Chen Xueying Shi Junjun Wang Yingchun Wu Xueli Cai Chunyun Shen Kai Li Pu Fang Ming Wang Zhongjun Chen Tong Li Guangsen Cheng Yaxuan Sun Yan Wang Hui Zhang Jie Chen Xiaohui Xu Youmeng Wang Wanjie Geng Chuyuan Ni Changchun Chen Yan Liu Jie Min Yongcheng Zhang Yong (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:The authors compare the effectiveness and safety of endovascular treatment (EVT) versus best medical management (BMM) in strokes attributable to acute basilar artery occlusion (BAO).METHODS:The present analysis was based on the ongoing, prospective, (...) (Circulation)
• 11:00
  Pregnancy and Spontaneous Coronary Artery Dissection: Lessons From Survivors and Nonsurvivors - Nathan Chan Diluka Premawardhana Abtehale Al-Hussaini Alice Wood Vasiliki Bountziouka Deevia Kotecha Eva Swahn Henning Palmefors Christos Pagonis Sofia Sederholm Lawesson Jacek K?dziela Marcos Garcia-Guimarães Fernando Alfonso Javier Escaned Fernando Macaya Melisa Santás Enrico Cerrato Angela H.E.M. Maas Ota Hlinomaz Nigussie Bogale Bernardo Cortese Mavis Cheng Aidan Bolger Shazia T. Hussain Nilesh J. Samani Marian Knight Matthew Cauldwell David Adlam Department of Cardiovascular Sciences, and NIHR Leicester Biomedical Research Centre, Leicester, UK Department of Cardiology and Department (...) Circulation
  Circulation, Ahead of Print. (Circulation)

J Human Hypertens http://www.nature.com/jhh/

• 00:00
  Strategies for improving the treatment and control of hypertension in Japan - Atsushi Sakima, Tetsutaro Matayoshi, Hisatomi Arima J Human Hypertens
  Journal of Human Hypertension, Published online: 03 June 2022; doi:10.1038/s41371-022-00708-7Strategies for improving the treatment and control of hypertension in Japan (Journal of Human Hypertension, Published online: 2022-06-03; | doi:10.1038/s41371-022-00708-7)

2 June

Lancet Diab Endocrinol https://www.thelancet.com/journals/landia/home

• 00:30
  [Comment] How should endocrinologists diagnose and treat non-alcoholic fatty liver disease? - Christopher D Byrne, Giovanni Targher Lancet Diab Endocrinol
  Non-alcoholic fatty liver disease (NAFLD) was first described in 1980 in a report from the Mayo Clinic that described the characteristics of non-alcoholic steatohepatitis in 20 patients.1 A liver biopsy showed “the presence of striking fatty changes with evidence of lobular hepatitis, focal (...) (The Lancet Diabetes & Endocrinology 10, 7 (2022))
• 00:30
  [In Focus] Diabetes in humanitarian crises - Talha Burki Lancet Diab Endocrinol
  As of May 31, 2022, an estimated 14 million Ukrainians had fled their homes since the Russia invasion earlier in the year. There are no guarantees that they will be able to return anytime soon. Refugees commonly spend years, sometimes decades, away from home. The war in Ukraine has pushed the (...) (The Lancet Diabetes & Endocrinology 10, 7 (2022))
• 00:30
  [Correspondence] Cross-sectional associations between the gut microbe Ruminococcus gnavus and features of the metabolic syndrome - Louise Grahnemo, Maria Nethander, Eivind Coward, Maiken Elvestad Gabrielsen, Satya Sree, Jean-Marc Billod, Lars Engstrand, Sanna Abrahamsson, Arnulf Langhammer, Kristian Hveem, Claes Ohlsson Lancet Diab Endocrinol
  It is well established that the gut microbiota influences obesity in mice. In humans, some gut microbes have been associated with obesity, 1,2 but results have been difficult to replicate, proposedly due to small studies and confounders.3,4 Insufficient control over medication use can interfere (...) (The Lancet Diabetes & Endocrinology 10, 7 (2022))
• 00:30
  [In Focus] Europe's obesity burden on the rise: WHO report - Vijay Shankar Balakrishnan Lancet Diab Endocrinol
  According to a report from WHO's Regional Office for Europe, released on May 3, 2022, the European region (comprising 53 countries in Europe and Central Asia) exhibits rates of overweight and obesity that are close to those in the Americas. “Obesity knows no borders [and] in Europe and Central (...) (The Lancet Diabetes & Endocrinology 10, 7 (2022))

Kidney Int http://www.kidney-international.org/

• 00:00
  Molecular mechanisms and therapeutic targets for diabetic kidney disease - Katherine R. Tuttle, Rajiv Agarwal, Charles E. Alpers, George L. Bakris, Frank C. Brosius, Peter Kolkhof, Jaime Uribarri Kidney Int
  Diabetic kidney disease has a high global disease burden and substantially increases the risk of kidney failure and cardiovascular events. Despite treatment, there is substantial residual risk of disease progression with existing therapies. Therefore, there is an urgent need to better (...) (Kidney International (2022))

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

• 07:00
  Blood pressure trajectories during pregnancy and preterm delivery: A prospective cohort study in China - Fanfan Chan, Songying Shen, Peiyuan Huang, Jianrong He, Xueling Wei, Jinhua Lu, Lifang Zhang, Xiaoyan Xia, Huimin Xia, Kar Keung Cheng, Shakila Thangaratinam, Ben Willem Mol, Xiu Qiu J Clin Hypertens
  The Journal of Clinical Hypertension, Volume 24, Issue 6, Page 770-778, June 2022. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

• 13:07
  Sex Differences in Temporal Trends of Cardiovascular Health in Young US Adults - So Mi Jemma Cho, Sara Haidermota , Michael C. Honigberg , and Pradeep Natarajan 1Program in Medical and Population Genetics and the Cardiovascular Disease Initiative Broad Institute of MIT and Harvard Cambridge MA 2Cardiovascular Research Center Massachusetts General Hospital Boston MA 3Department of Preventive Medicine Yonsei University College of Medicine Seoul Korea 4Integrative Research Center for Cerebrovascular and Cardiovascular Diseases Seoul Korea 5Cardiology Division Department of Medicine Harvard Medical School Boston (...) J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundFavorable cardiovascular health (CVH) in young adulthood has been associated with lower future cardiovascular risk. We determined whether CVH and its sex differences in young adults have changed from 2007 to (...) (Journal of the American Heart Association)

Diabetologia http://link.springer.com/

• 00:00
  Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes is characterised by hyperglucagonaemia and perturbed function of pancreatic glucagon-secreting alpha cells but the molecular mechanisms contributing to these phenotypes are poorly understood. Insulin-degrading enzyme (IDE) is present within all islet (...)

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

• 16:09
  The effect of mountaineering on the association between blood pressure and physical activity: A new multi?sensor ambulatory blood?pressure monitoring device. The Mount Fuji Study - Takahiro Komori, Satoshi Hoshide, Hidenori Kanazawa, Mizuri Taki, Noriyasu Suzuki, Praew Kotruchin, Kazuomi Kario J Clin Hypertens
  The Journal of Clinical Hypertension, Accepted Article. -- ORIGINAL ARTICLE (Wiley: The Journal of Clinical Hypertension: Table of Contents)
• 10:39
  Sonographic evaluation of hypertension: Role of atrophic index and renal resistive index - Antonietta Gigante, Adolfo Marco Perrotta, Oriana De Marco, Edoardo Rosato, Silvia Lai, Rosario Cianci J Clin Hypertens
  The Journal of Clinical Hypertension, EarlyView. -- OPINION (Wiley: The Journal of Clinical Hypertension: Table of Contents)

Stroke https://www.ahajournals.org/

• 11:00
  Sex Hormones and Risk of Aneurysmal Subarachnoid Hemorrhage: A Mendelian Randomization Study - Rob Molenberg Chris H.L. Thio Marlien W. Aalbers Maarten Uyttenboogaart Susanna C. Larsson Mark K. Bakker Ynte M. Ruigrok Harold Snieder J. Marc C. van Dijk Department of Neurosurgery (R.M., M.W.A., J.M.C.v.D.), University of Groningen, University Medical Center Groningen, the Netherlands. Department of Epidemiology (C.H.L.T., H.S.), University of Groningen, University Medical Center Groningen, the Netherlands. Department of Neurology and Medical Imaging Center (M.U.), University of Groningen, University Medical Center Groningen, the Netherlands. Unit of Cardiovascular and Nutritional (...) Stroke
  Stroke, Ahead of Print. Background:The risk of aneurysmal subarachnoid hemorrhage (aSAH) is increased in postmenopausal women compared with men of similar age, suggesting a role for sex hormones. We aimed to explore whether sex hormones, and age at menarche/menopause have a causal effect on (...) (Stroke)
• 11:00
  Diagnostic Utility of Computed Tomography Perfusion in the Telestroke Setting - Kshitij Arora Aaron Gaekwad James Evans William O’Brien Timothy Ang Carlos Garcia-Esperson Christopher Blair Leon S. Edwards Beng L.A. Chew Candice Delcourt Neil J. Spratt Mark W. Parsons Ken S. Butcher Prince of Wales Clinical School, University of New South Wales, Clinical Neurosciences, Randwick, Australia (K.A., A.G., K.S.B.). Gosford Hospital, Department of Neurosciences, Australia (J.E., W.O.B., L.S.E.). Departments of Neurology and Radiology, Royal Prince Alfred Hospital, Camperdown, Australia (T.A.). John Hunter Hospital, Department of Neurology, and Hunter Medical Research (...) Stroke
  Stroke, Ahead of Print. Background:Definitive diagnosis of acute ischemic stroke is challenging, particularly in telestroke settings. Although the prognostic utility of CT perfusion (CTP) has been questioned, its diagnostic value remains under-appreciated, especially in cases without an easily (...) (Stroke)
• 11:00
  Strategies for Maintaining Brain Health: The Role of Stroke Risk Factors Unique to Elderly Women - Bharti Manwani Carson Finger Lynda Lisabeth Department of Neurology, University of Texas Health Science Center at Houston (B.M., C.F.). Department of Epidemiology, University of Michigan, Ann Arbor (L.L.). Stroke
  Stroke, Ahead of Print. Stroke risk and prevalence increase with advanced age and women tend to be older than men at the time of their first stroke. Advanced age in women confers unique stroke risks that are beyond reproductive factors. Previous reviews and guidelines have largely focused on (...) (Stroke)

Hypertension https://www.ahajournals.org/

• 11:01
  Novel Drug Delivery Technologies and Targets for Renal Disease - Alejandro R. Chade Gene L. Bidwell The Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson. (A.R.C.) the Department of Medicine, University of Mississippi Medical Center, Jackson. (A.R.C.) the Department of Radiology, University of Mississippi Medical Center, Jackson. (A.R.C.) the Department of Neurology, University of Mississippi Medical Center, Jackson. (G.L.B.) the Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson. (G.L.B.) the Department of Pharmacology, University of Mississippi Medical Center, Jackson. (...) Hypertension
  Hypertension, Ahead of Print. The burden of acute and chronic kidney diseases to the health care system is exacerbated by the high mortality that this disease carries paired with the still limited availability of comprehensive therapies. A reason partially resides in the complexity of the (...) (Hypertension)
• 11:01
  Performance of Confirmatory Tests for Diagnosing Primary Aldosteronism: a Systematic Review and Meta-Analysis - Alexander A. Leung Christopher J. Symonds Gregory L. Hundemer Paul E. Ronksley Diane L. Lorenzetti Janice L. Pasieka Adrian Harvey Gregory A. Kline Division of Endocrinology and Metabolism, Department of Medicine (A.A.L., C.J.S., G.A.K.), University of Calgary, AB. Department of Community Health Sciences (A.A.L., P.E.R., D.L.L.), University of Calgary, AB. Department of Surgery (J.L.P., A.H.), University of Calgary, AB. Department of Oncology (J.L.P., A.H.), University of Calgary, AB. Division of Nephrology, Department of Medicine and the Ottawa Hospital Research Institute, University of (...) Hypertension
  Hypertension, Ahead of Print. Background:Confirmatory tests are recommended for diagnosing primary aldosteronism, but the supporting evidence is unclear.Methods:We searched Medline, EMBASE, and the Cochrane Central Register of Controlled Trials. Studies evaluating any guideline-recommended (...) (Hypertension)
• 11:00
  Dapagliflozin Attenuates Sympathetic and Pressor Responses to Stress in Young Prehypertensive Spontaneously Hypertensive Rats - Han-Kyul Kim Rie Ishizawa Ayumi Fukazawa Zhongyun Wang Ursa Bezan Petric Ming Chang Hu Scott A. Smith Masaki Mizuno Wanpen Vongpatanasin Departments of Internal Medicine-Hypertension Section, University of Texas Southwestern Medical Center, Dallas. (H.-K.K., Z.W., U.B.P., W.V.) Applied Clinical Research, University of Texas Southwestern Medical Center, Dallas. (H.-K.K., R.I., A.F., S.A.S., M.M.) Internal Medicine-Renal Division, University of Texas Southwestern Medical Center, Dallas. (M.C.H.) Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical (...) Hypertension
  Hypertension, Ahead of Print. Background:SGLT2i (sodium-glucose cotransporter 2 inhibitor), a class of anti-diabetic medications, is shown to reduce blood pressure (BP) in hypertensive patients with type 2 diabetes. Mechanisms underlying this action are unknown but SGLT2i-induced (...) (Hypertension)
• 11:00
  Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension - Tanika N. Kelly Xiao Sun Karen Y. He Michael R. Brown Sarah A. Gagliano Taliun Jacklyn N. Hellwege Marguerite R. Irvin Xuenan Mi Jennifer A. Brody Nora Franceschini Xiuqing Guo Shih-Jen Hwang Paul S. de Vries Yan Gao Arden Moscati Girish N. Nadkarni Lisa R. Yanek Tali Elfassy Jennifer A. Smith Ren-Hua Chung Amber L. Beitelshees Amit Patki Stella Aslibekyan Brandon M. Blobner Juan M. Peralta Themistocles L. Assimes Walter R. Palmas Chunyu Liu Adam P. Bress Zhijie Huang Lewis C. Becker Chii-Min Hwa Jeffrey R. O’Connell Jenna C. Carlson Helen R. Warren Sayantan Das Ayush Giri Lisa W. Martin (...) Hypertension
  Hypertension, Ahead of Print. Background:The availability of whole-genome sequencing data in large studies has enabled the assessment of coding and noncoding variants across the allele frequency spectrum for their associations with blood pressure.Methods:We conducted a multiancestry (...) (Hypertension)
• 11:00
  Longitudinal Changes in Cardiac Structure and Function in Pediatric Kidney Transplant Recipients - Isabel de Verteuil Jessica Fitzpatrick Ana Catalina Alvarez Elias Tonny Banh Jovanka Vasilevska-Ristovska Jordan Browne Bianca C. Bondi Wei Hui Cameron Slorach Chia Wei Teoh Valerie Langlois Luc Mertens Rulan S. Parekh Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children. (I.d.V., J.F., A.C.A.E., T.B., J.V.-R., J.B., B.C.B., C.W.T., R.S.P.) Labatt Family Heart Center, The Hospital for Sick Children. (W.H., C.S., L.M.) Division of Nephrology, The Hospital for Sick Children and University Health Network (A.C.A.E., C.W.T., V.L., R.S.P.). Institute of Health (...) Hypertension
  Hypertension, Ahead of Print. Background:Cardiovascular disease results in increased morbidity and mortality in pediatric kidney transplant recipients. Longitudinal changes in cardiac structure and function and the association with blood pressure control over time in pediatric kidney transplant (...) (Hypertension)

Circulation http://ahajournals.org/

• 11:01
  Association of Cardiovascular Health Through Young Adulthood With Genome-Wide DNA Methylation Patterns in Midlife: The CARDIA Study - Yinan Zheng Brian Joyce Shih-Jen Hwang Jiantao Ma Lei Liu Norrina Allen Amy Krefman Jun Wang Tao Gao Drew Nannini Haixiang Zhang David R. Jacobs Myron Gross Myriam Fornage Cora E. Lewis Pamela J. Schreiner Stephen Sidney Dongquan Chen Philip Greenland Daniel Levy Lifang Hou Donald Lloyd-Jones Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Z., B.J., N.A., A.K., J.W., T.G., D.N., P.G., L.H., D.L.-J.). Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (S.-J.H., D.L.). (...) Circulation
  Circulation, Ahead of Print. BACKGROUND:Cardiovascular health (CVH) from young adulthood is strongly associated with an individual’s future risk of cardiovascular disease (CVD) and total mortality. Defining epigenomic biomarkers of lifelong CVH exposure and understanding their roles in CVD (...) (Circulation)
• 11:00
  hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration - Jisheng Sun Elizabeth A. Peterson Annabel Z. Wang Jianhong Ou Kieko E. Smith Kenneth D. Poss Jinhu Wang Division of Cardiology, School of Medicine, Emory University, Atlanta, GA (J.S., E.A.P., K.E.S., J.W.). Duke Regeneration Center, Department of Cell Biology, Duke University Medical Center, Durham, NC (A.Z.W., J.O., K.D.P.). Circulation
  Circulation, Ahead of Print. BACKGROUND:Certain nonmammalian species such as zebrafish have an elevated capacity for innate heart regeneration. Understanding how heart regeneration occurs in these contexts can help illuminate cellular and molecular events that can be targets for heart failure (...) (Circulation)

Diabetologia http://link.springer.com/

• 00:00
  Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation Diabetologia
  Abstract Aims/hypothesis Type 2 diabetes is characterised by hyperglucagonaemia and perturbed function of pancreatic glucagon-secreting alpha cells but the molecular mechanisms contributing to these phenotypes are poorly understood. Insulin-degrading enzyme (IDE) is present within all islet (...)

1 June

J Clin Hypertens http://onlinelibrary.wiley.com//journal/10.1111/(ISSN)1751-7176

• 03:08
  Meta?analysis on the association between the frequency of tooth brushing and hypertension risk - Li Zou, Mingye Zhang, Wenning Fu, Yifang Liu, Jing Wen, Zuxun Lu J Clin Hypertens
  The Journal of Clinical Hypertension, Volume 24, Issue 6, Page 689-697, June 2022. -- META?ANALYSIS (Wiley: The Journal of Clinical Hypertension: Table of Contents)

Diabetes https://diabetes.diabetesjournals.org

• 02:00
  718-P: Patients Achieving an HbA1c <5.7% with =5% Weight Loss and without Hypoglycemia: A Post Hoc Analysis of SURPASS 1 to 5 - CHENG AY, LINGVAY I, CHOUDHARY P, et al. Diabetes
  In the phase 3 SURPASS studies of tirzepatide (TZP) , a novel dual GIP/GLP-1 receptor agonist developed for the treatment of type 2 diabetes, 23%-62% of TZP-treated participants achieved a HbA1c Disclosure A.Y. Cheng: Advisory Panel; Abbott, AstraZeneca, Bayer AG, Boehringer Ingelheim (...)

JAMA Cardiology https://jamanetwork.com/journals/jamacardiology

• 02:00
  Error in Abstract Results Section JAMA Cardiology
  The Brief Report titled “Association of Low-Dose Triple Combination Therapy vs Usual Care With Time at Target Blood Pressure: A Secondary Analysis of the TRIUMPH Randomized Clinical Trial,” published on April 13, 2022, was corrected to fix a typographical error in the Abstract Results section. In (...)
• 02:00
  JAMA Cardiology JAMA Cardiology
  Mission Statement:? JAMA Cardiology is positioned at the nexus of clinical investigation, actionable clinical science, and clinical practice, with emphasis on traditional cardiovascular medicine, evolving cardiovascular science, and evidence-based health policy. Health equity, especially when (...)
• 02:00
  Treatment of Out-of-Hospital Cardiac Arrest - Lascarrou J, Nichol G. JAMA Cardiology
  Achieving and maintaining good neurologic function and health-related quality of life after discharge are key goals for those who are affected by or care for those with out-of-hospital cardiac arrest (OHCA). Inaccurate early assessment of prognosis and consequent withdrawal of life-sustaining (...)
• 02:00
  Could Neprilysin Be Already Inhibited by BNP in the LIFE Trial? - Vodovar N, Cohen-Solal A, Logeart D. JAMA Cardiology
  To the Editor In the LCZ696 in Hospitalized Advanced Heart Failure (LIFE) trial, the authors reported no benefit of sacubitril/valsartan over valsartan on the primary end points or decrease in plasma N-terminal pro–brain natriuretic peptide (NT-proBNP). Data from Prospective Comparison of ARNI (...)
• 02:00
  Could Neprilysin Be Already Inhibited by BNP in the LIFE Trial?—Reply - Mann DL, Hernandez AF, Braunwald E. JAMA Cardiology
  In Reply In the LCZ696 in Hospitalized Advanced Heart Failure (LIFE) trial, we did not observe a statistically significant difference between sacubitril/valsartan and valsartan with respect to the time-averaged proportional change in the area under the curve (AUC) for N-terminal pro–brain (...)
• 02:00
  Trends in 10-Year Outcomes Among Medicare Beneficiaries Who Survived an Acute Myocardial Infarction - Wang Y, Leifheit EC, Krumholz HM. JAMA Cardiology
  This cohort study evaluates trends in 10-year all-cause mortality and hospitalization for recurrent acute myocardial infarction by demographic subgroups and examines the association between recurrence and mortality.
• 02:00
  Long-term Survival After Out-of-Hospital Cardiac Arrest - Amacher SA, Bohren C, Blatter R, et al. JAMA Cardiology
  This meta-analysis of patients with out-of-hospital cardiac arrest assesses the long-term survival rate in those who survive the initial hospital stay.
• 02:00
  Association of COVID-19 Vaccination With Outcomes in Heart Transplant Recipients - Peters LL, Raymer DS, Pal JD, et al. JAMA Cardiology
  This case-control study assesses data from a single center about the safety and effectiveness of COVID-19 vaccination among patients who received an orthotopic heart transplant.
• 02:00
  Who Is at Risk for Heart Failure? - Yancy CW, Khan SS. JAMA Cardiology
  The availability of evidence-based medical interventions to prevent the onset of signs and symptoms of heart failure (HF) affords a unique opportunity to attenuate the risk for a disease with substantial morbidity and mortality. Targeting prevention of HF is an apt goal. Yet determining those (...)
• 02:00
  Sex and Race Differences in NT-proBNP Concentration and Absolute Risk of Heart Failure in the Community - Myhre PL, Claggett B, Yu B, et al. JAMA Cardiology
  This cohort study aims to determine whether physiologic determinants of N-terminal pro–B-type natriuretic peptide concentrations account for sex and race differences and aims to more uniformly predict heart failure risk.
• 02:00
  Current Landscape and Future Directions of Coronary Revascularization in Patients With Heart Failure - Ahmad Y, Lansky AJ, Velazquez EJ. JAMA Cardiology
  This Viewpoint discusses current options and future directions for coronary artery revascularization for the management of coronary artery disease in patients with heart failure.
• 02:00
  Communicating the Benefits of Vaccination in Light of Potential Risks - Navar A, Bonow RO. JAMA Cardiology
  Since the initial case reports of myocarditis following COVID-19 vaccination, several population-based studies have demonstrated an increased risk of myocarditis following vaccination, including nationwide studies in England and Israel. In this issue of JAMA Cardiology, Karlstad and colleagues (...)
• 02:00
  No Diagnostic Concerns With Cardiovascular Magnetic Resonance Imaging in Patients With Breast Cancer and Breast Implants - Manisty C, Barac A, Lenihan D. JAMA Cardiology
  To the Editor We welcome the Viewpoint from Oren et al highlighting the importance of ensuring high-quality cardiovascular (CV) imaging for patients living with (or survivors of) breast cancer with breast implants. Patients commonly require functional CV imaging to establish CV safety during or (...)
• 02:00
  No Diagnostic Concerns With Cardiovascular Magnetic Resonance Imaging in Patients With Breast Cancer and Breast Implants—Reply - Oren O, Blankstein R, Bhatt DL. JAMA Cardiology
  In Reply We thank Manisty et al for the opportunity to further reinforce the strengths and potential pitfalls of contemporary cardiovascular imaging in women who have been diagnosed with breast cancer and who underwent breast reconstruction. Cardiac magnetic resonance imaging (CMR) represents (...)
• 02:00
  Gamification Intervention to Improve Physical Activity in Postpartum Individuals With Hypertensive Disorders of Pregnancy - Lewey J, Murphy S, Zhang D, et al. JAMA Cardiology
  This randomized clinical trial determines whether a digital health intervention can improve physical activity in postpartum individuals with hypertensive disorders of pregnancy.
• 02:00
  SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort Study of 23 Million Residents - Karlstad Ø, Hovi P, Husby A, et al. JAMA Cardiology
  This cohort study conducted using nationwide registers assesses the risks of myocarditis and pericarditis after SARS-CoV-2 messenger RNA vaccinations in a combined population of 23.1 million individuals across Denmark, Finland, Norway, and (...)
• 02:00
  Association of Low-Dose Triple Combination Therapy vs Usual Care With Time at Target Blood Pressure - Gnanenthiran SR, Wang N, Di Tanna G, et al. JAMA Cardiology
  This post hoc analysis of a randomized clinical trial evaluates the association of time at target blood pressure with low-dose triple combination antihypertensive therapy vs usual care.
• 02:00
  Meaningful Evidence for Anticoagulation in the Gray (Elder) Zone - Alexander KP. JAMA Cardiology
  As more people are living longer lives, the number of older adults with atrial fibrillation (AF), a common age-associated condition, will increase. Advanced age coincides with changes in kidney and hepatic function, body mass and composition, and use of concomitant therapies with the potential (...)
• 02:00
  Edoxaban in Older Patients With Atrial Fibrillation - Kuroda M, Tamiya E, Nose T, et al. JAMA Cardiology
  This randomized clinical trial investigates the effect of 15-mg edoxaban in patients aged 80 years and older who are not candidates for standard-dose oral anticoagulants owing to bleeding risk.
• 02:00
  My Grandfather’s Blueprint - Love K. JAMA Cardiology
  This essay describes the author’s experience building a canoe during medical school and residency.

J Am Heart Assoc https://www.ahajournals.org/feeds.jsp

• 03:34
  Blood Pressure–Lowering Effects of Omega?3 Polyunsaturated Fatty Acids: Are These the Missing Link to Explain the Relationship Between Omega?3 Polyunsaturated Fatty Acids and Cardiovascular Disease? - Marc George, and Ajay Gupta 1 Department of Clinical Pharmacology and Therapeutics University College London Hospitals NHS Foundation Trust London United Kingdom 2 Institute of Cardiovascular Science University College London London United Kingdom 3 Department of Clinical Pharmacology William Harvey Research Institute, Queen Mary University of London London United Kingdom 4 Royal London Hospital Barts Health NHS Trust London United Kingdom J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. (Journal of the American Heart Association)
• 03:00
  Omega?3 Polyunsaturated Fatty Acids Intake and Blood Pressure: A Dose?Response Meta?Analysis of Randomized Controlled Trials - Xin Zhang, Jennifer A. Ritonja , Na Zhou , Bingshu E. Chen , and Xinzhi Li 1School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicines Macau University of Science and Technology Taipa Macau China 2Department of Public Health Sciences and Canadian Cancer Trials Group Queen's University Kingston Ontario Canada J Am Heart Assoc
  Journal of the American Heart Association, Volume 11, Issue 11, June 7, 2022. BackgroundCurrent evidence might support the use of omega?3 fatty acids (preferably docosahexaenoic acid and eicosapentaenoic acid) for lowering blood pressure (BP), but the strength and shape of the dose?response (...) (Journal of the American Heart Association)

Curr Opin Endocrinol http://journals.lww.com/co-endocrinology

• 07:00
  Editorial introductions Curr Opin Endocrinol
  No abstract available -- EDITORIAL INTRODUCTIONS
• 07:00
  Pathophysiology of bilateral hyperaldosteronism - Nanba, Kazutaka; Rainey, William E. Curr Opin Endocrinol
  Purpose of review Renin-independent aldosterone production from one or both affected adrenal(s), a condition known as primary aldosteronism (PA), is a common cause of secondary hypertension. In this review, we aimed to summarize recent findings regarding pathophysiology of bilateral forms of (...) -- ADRENAL CORTEX AND MEDULLA: Edited by Diane Donegan and Danae Delivanis
• 07:00
  Current approach of primary bilateral adrenal hyperplasia - Delivanis, Danae A.; Vassiliadi, Dimitra A.; Tsagarakis, Stylianos Curr Opin Endocrinol
  Purpose of review To discuss the most recent findings on the pathophysiology, the genetic and molecular causes of primary bilateral adrenal hyperplasia (PBAH). The diagnostic approach of patients with PBAH will also be presented in detail with an emphasis on the emerging diagnostic tools and (...) -- ADRENAL CORTEX AND MEDULLA: Edited by Diane Donegan and Danae Delivanis
• 07:00
  Optimal and novel imaging of the adrenal glands - Navin, Patrick J.; Moynagh, Michael R. Curr Opin Endocrinol
  Purpose of review Adrenal imaging forms an important role in the workup of adrenal masses. The purpose of this review is to briefly review the traditional role of imaging in adrenal diseases and highlight the most recent research and new applications aimed to improve diagnostic accuracy. Recent (...) -- ADRENAL CORTEX AND MEDULLA: Edited by Diane Donegan and Danae Delivanis
• 07:00
  The uncommon forms of congenital adrenal hyperplasia - Auchus, Richard J. Curr Opin Endocrinol
  Purpose of review Clinicians recognize 21-hydroxylase deficiency as the most common form of congenital adrenal hyperplasia (CAH), and many papers have been published on this condition. In contrast, much less awareness has been addressed to the other, rare forms of CAH. Recent findings The (...) -- ADRENAL CORTEX AND MEDULLA: Edited by Diane Donegan and Danae Delivanis
• 07:00
  Emerging treatment for congenital adrenal hyperplasia - White, Perrin C. Curr Opin Endocrinol
  Purpose of review Although the basic treatment of congenital adrenal hyperplasia (CAH) is well established, there are active clinical research projects to more closely mimic the normal diurnal rhythm of cortisol secretion and to reduce total glucocorticoid doses to minimize adverse metabolic (...) -- ADRENAL CORTEX AND MEDULLA: Edited by Diane Donegan and Danae Delivanis
• 07:00
  Adrenal insufficiency and pregnancy - Alexandraki, Krystallenia I.; Kaltsas, Gregory A. Curr Opin Endocrinol
  Introduction Adrenal insufficiency is a disorder characterized by the failure of adrenocortical function because of distorted function of hypothalamic–pituitary– adrenal (HPA) axis. Pregnancy is a state of a physiological glucocorticoid excess as the HPA axis is functioning at a higher level. (...) -- ADRENAL CORTEX AND MEDULLA: Edited by Diane Donegan and Danae Delivanis
• 07:00
  The role for long-term use of dehydroepiandrosterone in adrenal insufficiency - Bennett, Gillian; Cussen, Leanne; O’Reilly, Michael W. Curr Opin Endocrinol
  Purpose of review Dehydroepiandrosterone (DHEA) is an androgen produced by the zona reticularis of the adrenal gland. Patients with adrenal insufficiency will have a deficiency of DHEA. Unlike glucocorticoid and mineralocorticoid replacement, DHEA supplementation is not considered essential for (...) -- ADRENAL CORTEX AND MEDULLA: Edited by Diane Donegan and Danae Delivanis
• 07:00
  Supportive management of patients with pheochromocytoma/paraganglioma undergoing noninvasive treatment - Talvacchio, Sara; Nazari, Matthew A.; Pacak, Karel Curr Opin Endocrinol
  Purpose of review Many publications review perioperative management of pheochromocytomas/paragangliomas (PPGLs); however, a large population, including 10–20% of metastatic PPGL patients, have inoperable disease. This has necessitated the development of noninvasive treatments (e.g., (...) -- ADRENAL CORTEX AND MEDULLA: Edited by Diane Donegan and Danae Delivanis