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In the face of novel pathogens, incomplete knowledge, and disagreement about the merits of medical treatments, translating the duty to care into concrete benefits for patients depends on our ability to quickly act on the duty to learn. Learning is a dynamic process whose goal, in medical (...)
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A Cochrane meta-analysis of 11 eligible trials examining the efficacy of ivermectin for the treatment of COVID-19 published through April 2022 concluded that ivermectin has no beneficial effect for people with COVID-19. Since May 2022, an additional 3 large randomized clinical trials including (...)
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This platform randomized clinical trial examines the effectiveness of ivermectin at a targeted dose of 600 ?g/kg daily compared with placebo for the treatment of early mild to moderate COVID-19.
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This Viewpoint summarizes several federal strategies to ensure pregnant persons’ access to abortion services after the recent Supreme Court ruling in Dobbs v Jackson Women’s Health Organization: expanding access to medication abortion, ensuring provision of emergency abortion services, proposing (...)
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In the US Preventive Services Task Force Updated Evidence Report and Systematic Review titled “Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force,” published in the (...)
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Listen to the JAMA Editor’s Audio Summary for an overview and discussion of the important articles appearing in this week’s issue of JAMA.
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Oct. 16, 1758, there was born, in the best front room of a farmhouse, in the primitive farming village of West Hartford, Conn., a male infant destined to play a very important part in the intellectual development of “these United States of America.” Noah Webster is known today, by name, to every (...)
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This study assesses the association between use of levonorgestrel intrauterine systems containing 52, 19.5, and 13.5 mg of hormone and ectopic pregnancy in a nationwide cohort study.
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This study uses American Hospital Association data to examine the volume and distribution of births in Catholic US hospitals and quantify county-level patterns of Catholic and non-Catholic hospital births.
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To the Editor A recent retrospective observational study concluded that longer intervals between hemodialysis and surgery were significantly associated with increased 90-day mortality in Medicare beneficiaries. Although this was a pragmatic analysis of a large cohort, we are concerned that this (...)
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To the Editor We are disappointed that a recent USPSTF Recommendation Statement failed to recommend menopausal hormone therapy for primary prevention of chronic diseases in postmenopausal persons.
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To the Editor A recent US Preventive Services Task Force (USPSTF) Recommendation Statement concluded that hormone therapy for postmenopausal persons presents some benefits and extensive risks of harm. Symptom relief therapy was endorsed, but evidence for long-term therapy for prevention of (...)
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To the Editor The WHI placebo-controlled trial involved 10 739 postmenopausal women with prior hysterectomy, and breast cancer incidence was the primary safety outcome. At 20.3-year follow-up, prior randomized use of conjugated equine estrogen alone was significantly associated with lower (...)
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To the Editor The USPSTF provides an important service in summarizing the relevant data about preventive interventions, but it was surprising and disheartening to see the updated Evidence Report for the USPSTF hold the WHI menopausal hormone therapy trials in such low regard. Among the many (...)
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In Reply The Letter from Dr Pal and colleagues about our recent study raises several important points. First, we agree that the ideal exposure would have been the number of hours between the last preoperative hemodialysis session and surgery. Unfortunately, this information was not available in (...)
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In Reply Regarding our systematic review on hormone therapy for the primary prevention of chronic conditions in postmenopausal persons, Dr Anderson and Dr Chlebowski and Mr Aragaki express concern about our assessment of the methodological quality of the WHI, which we rated as fair quality or (...)
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In Reply In their Letters, Dr Nachtigall and colleagues and Dr Glynne and colleagues note that there may be differences in the benefits and harms of menopausal hormone therapy to prevent chronic conditions based on the age of persons using this treatment or on time since menopause. For its (...)
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This randomized clinical trial examines the expulsion rate of intrauterine devices placed between 2 to 4 weeks postpartum compared with standard placement timing at 6 to 8 weeks postpartum.
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I wonder if it is the slow leaching of ions from their beautiful lattice. As I wake, I trace the aching outline of my bones. Notice first my clavicles Then each fragile vertebra and those hips Step onto the floor and stifle a (...)
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This narrative review discusses the pathophysiology, clinical presentation, and diagnosis, and staging of chronic lymphocytic leukemia and summarizes current treatments.
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Life expectancy in the US is now the lowest it has been since 1996, with young- and middle-aged adults seeing the most rapid declines. These declines began in 2014 and have accelerated over the past 3 years of the pandemic. While COVID-19 represents a significant proportion, increases in heart (...)
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This study assesses the prevalence rates of cardiovascular risk factors (hypertension, diabetes, hyperlipidemia, obesity, and tobacco use), treatment, and control among adults aged 20 to 44 years from 2009 through March 2020, overall and by sex and race and (...)
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In this narrative medicine essay, a physician describes the importance of paying attention to the deliberate words patients choose and how physicians must seek to understand why they are chosen rather than translating those words to what they expect to (...)
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Immunity generated by COVID-19 infection protects against hospitalization and death, according to a meta-analysis of 65 studies representing data from 19 countries. Protection against severe disease remained high after 40 weeks, at 90.2% for ancestral, Alpha, and Delta variants and 88.9% for (...)
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More than one-third of patients hospitalized with COVID-19 had lung abnormalities including scarring and thickening 2 years later, according to an analysis of chest computed tomographic (CT) scans from 144 participants aged 27 to 80 (...)
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Treatment with radiotherapy alongside breast-conserving surgery and hormone therapy did not improve overall or breast cancer–specific survival, investigators recently reported. It also did not decrease the incidence of distant recurrence as a first event, according to a phase 3 clinical trial (...)
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A single dose of an experimental compound inactivated sperm in male mice within 30 minutes for up to 2.5 hours and prevented pregnancy in a proof-of-concept study. The researchers also found that the treatment, known as TDI-11861, was safe and did not cause severe adverse effects such as organ (...)
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Chronic pain, especially at multiple sites in the body, was linked to a higher risk of dementia in a study of more than 350 000 UK Biobank participants aged 39 to 73 years. After adjustments for potential confounders, participants who reported a single site of pain had a 15% higher risk of (...)
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After adjusting for maternal confounders, children born to mothers who continued to use attention-deficit/hyperactivity disorder (ADHD) medications during pregnancy were no more likely to have neurodevelopmental disorders than those whose mothers discontinued use, according to a (...)
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In mid-February, the US Department of Health and Human Services (HHS) announced another step toward strengthening transparency around nursing home ownership. Under the proposed rule, nursing homes enrolled in Medicaid or Medicare would be required to disclose more information about ownership (...)
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Manufacturers of most infant formulas claim a range of benefits, such as supporting infants’ brain and eye development, strengthening their immune systems, and easing digestion, based on an analysis of 757 products from 15 countries.
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A normal gastrointestinal (GI) tract biopsy result might not eliminate an inflammatory bowel disease (IBD) diagnosis, according to a population-based, sibling-controlled study published in PLOS Medicine.
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This Medical News article discusses a new study in JAMA Surgery about outcome differences between women and men after the most common surgical treatment for coronary artery disease.
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This article in the Women’s Health series discusses uterine perforation occurring during gynecological procedures, including prevention, identification of risk factors, recognition, management, and long-term outcomes.
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This JAMA Patient Page describes melanoma, its risk factors, diagnosis, treatment, and prognosis.
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This Medical News article is an interview about new policy from the US Organ Procurement and Transplantation Network to address the harms of race-based kidney function estimation.
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This Viewpoint discusses how the Kidney Donor Profile Index (KDPI) in its current form is not fit to guide kidney allocation because it devalues organ donation by Black donors based on a weak association between donor race and kidney transplant (...)
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This Viewpoint emphasizes the urgency of abolishing race-based medical practices and explains how they have unjustly contributed to racial inequities in clinical care and health outcomes.